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António Sebastião Rodrigues. Completed his PhD in Biology, Molecular Genetics in 1994 by Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia and Licenciatura in Biochemistry in 1987 by Universidade de Lisboa, Faculdade de Ciências. He obtained an Agregação from the Universidade Nova de Lisboa, NOVA Medical School in 2020. Currently he is Associate Professor in Universidade NOVA de Lisboa, NOVA Medical School. Up to 2023, he published more than 70 articles in International peer reviewed journals, 8 book chapters and edited 1 book, with an h-factor of 25. He participates and/or participated as Researcher in 4 project(s). He works in the area(s) of Medical and Health Sciences with emphasis on Human Genetics, Medical and Health Sciences, and Toxicology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Epigenetics; MicroRNAs; Untranslated RNAs; Drug resistance; Radiobiology; Science & Technology.
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Identification

Personal identification

Full name
António Sebastião Rodrigues

Citation names

  • Rodrigues, António Sebastião

Author identifiers

Ciência ID
9012-44BE-F79D
ORCID iD
0000-0002-8139-4595
Researcher Id
A-1930-2013
Scopus Author Id
36130557500

Telephones

Mobile phone
  • 968581092 (Personal)

Addresses

  • Rua Câmara Pestana, n.ºs 6, 6-A e 6-B, 1150-082, Lisbon, Lisbon, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Medical and Health Sciences - Basic Medicine - Toxicology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2020/07/03 - 2020/07/03
Concluded
 Antonio Sebastião Rodrigues (Título de Agregado)
Universidade Nova de Lisboa, Portugal
1994
Concluded
 Biologia (Doutoramento)
Major in Especialidade: Genética Molecular
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Contribuição para o Estudo da Metabolização de Agentes Genotóxicos" (THESIS/DISSERTATION)
1987
Concluded
 António Sebastião Rodrigues (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 15
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2021/06/17 - Current Associate Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2005 - 2021/06/16 Assistant Professor (University Teacher) Universidade Nova de Lisboa, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - 2018 Assistant Professor (University Teacher) Universidade Nova de Lisboa, Portugal
2013 - 2016 Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
1995 - 2005 Associate Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias, Portugal
Universidade Lusófona de Humanidades e Tecnologias, Portugal
Projects

Grant

Designation Funders
2018/10/01 - 2021/10/01 Comprehensive Evaluation of Circulating MicroRNA as Diagnostic and Prognostic Biomarkers in Amyotrophic Lateral Sclerosis
PTDC/MEC-NEU/31195/2017
Researcher
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017 - 2019 Breast Cancer: clinical significance of unknown variants (UVs) in homologous recombination repair genes? From sequencing to functional analysis in familial breast cancer patients.
LPCC
Researcher
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
 Terry Fox Foundation
Concluded
2006 - 2009 Mechanisms of Resistance to Imatinib in Chronic Myeloid Leukemia
PTDC/SAU-GMG/71720/2006
Researcher
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
 Fundação para a Ciência e a Tecnologia
2006 - 2009 Chemical, Radiochemical and Biological Studies of Pyrazolyl-Alkylamine Pt(II) Complexes: Application on the Development of Novel Anti-cancer Drugs.
PTDC/QUI/66813/2006
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2004 - 2007 COMPLEXOS MULTIFUNCIONAIS DE TECNÉCIO E GÁLIO PARA RADIOTERAPIA SELECTIVA
POCI/QUI/57632/2004
Researcher
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2011/01/01 - 2013/12/31 Strategic Project - UI 9 - 2011-2012
PEst-OE/SAU/UI0009/2011
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Rodrigues, António Sebastião. Cancer Drug Resistance. New York, United States: Springer New York. 2016.
    10.1007/978-1-4939-3347-1 • Editor
  2. Monteiro, M.; Rodrigues, A. S.; Vicente, A.; Murias, J.; Martins, C.; Rueff, J.; Borba, H.; Medimond,. Potassium bromate oxidative DNA damage in repair proficient and deficient CHO cell lines. 2007.
  3. Rodrigues, António Sebastião. DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells. Boston, United States: Springer US. 1989.
    Published • 10.1007/978-1-4684-1327-4
Book chapter
  1. Martins, C.; Rueff, J.; Rodrigues, A.S.. "Myristicin". edited by Dongyou Liu. 2018.
  2. Oliveira NG; Miranda JP; Costa JG; Rodrigues, António Sebastião; Castro, Matilde; Fernandes, Ana S. "Toxicodinâmica". In Toxicologia Fundamental, edited by Oliveira RD, Carvalho FD, Bastos ML, 35-63. Portugal: Lidel, 2018.
    Published
  3. Rodrigues, António. "DNA Repair and Resistance to Cancer Therapy". 2013.
    10.5772/53952
  4. Rodrigues, António. "Prooxidant activities of flavonols: a structure-activity study.". Germany, 1996.
    10.1002/food.19970410232
  5. Rodrigues, António. "DNA Damage and Oxygen Species.". United States, 1989.
    10.1007/978-1-4684-1327-4
Conference paper
  1. Coelho, Marta C.; Pereira, Ricardo; Teixeira, José A.; Rodrigues, António S.; Pintado, Manuela. "Electric fields effects on carotenoids from tomato by-products". 2017.
  2. Rodrigues, António. "Epigenetic changes after prolonged exposure to alkenylbenzenes–An important signature of potential toxicological effects.". 2015.
    10.1016/j.toxlet.2015.08.288
  3. Rodrigues, António Sebastião. "Activation of promutagens by rat cyt.P450 expressing V79 cells". Paper presented in Cytochrome P450: Biochemistry, Biophysics, and Molecular Biology, Lisbon, 1993.
    Published
Conference poster
  1. Adubeiro-Lourenço, Rita; Lança, Miguel; Octávia M. Gil; Rodrigues, António Sebastião; José Rueff; Nunes Silva, Susana. "BRCA1 VUS: THE LINE BETWEEN BENIGN AND PATHOGENIC CLASSIFICATION". Paper presented in 26th Annual Meeting of the Portuguese Society of human Genetics, 2022.
  2. Silva, Catarina; Machado, Miguel; Rodrigues, António Sebastião; Vieira, Luís. "Nanopore sequencing: A fast, unbiased and sensitive approach to study human genome methylation". Paper presented in Revolutionizing Next-Generation Sequencing (Virtual 4th Edition), 2021.
  3. Silva, Catarina; Machado, Miguel; Rodrigues, António Sebastião; Vieira, Luís. "NANOPORE SEQUENCING ALLOWS HIGH QUALITY CpG METHYLATION CALLS IN HUMAN GENOME". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics, 2020.
  4. Marta Coelho; Ezequiel R Coscueta; Silva, Sara; João C Fernandes; Ricardo Pereira; Rodrigues, António Sebastião; teixeira, José; Maria Manuela Pintado. "Biological properties of grape by-products promoted by Ohmic Heating technology". Paper presented in XII Iberoamerican Congress of Food Engineering, 2019.
  5. Marta Coelho; Célia Costa; Roberta Andrade; Silva, Sara; Ana Rita Monforte; Rodrigues, António Sebastião; Teixeira, José A; Maria Manuela Estevez Pintado. "Gut microbiota impact on the biotransformation of polyphenols from tomato by-products". Paper presented in 2nd Conference on Food Bioactives & Health, 2018.
  6. Borges, André; Silva, Sara; Coelho, Marta; Gião, Maria; Rodrigues, António Sebastião; Maria Manuela Estevez Pintado. "Characterization of the Biological Properties and Toxicity of Quercus extracts". Paper presented in International Horticultural Congress, 2010.
Journal article
  1. Marta C. Coelho; Célia Costa; Dalila Roupar; Sara Silva; A. Sebastião Rodrigues; José A. Teixeira; Manuela E. Pintado. "Modulation of the Gut Microbiota by Tomato Flours Obtained after Conventional and Ohmic Heating Extraction and Its Prebiotic Properties". Foods (2023): https://doi.org/10.3390/foods12091920.
    10.3390/foods12091920
  2. Marta C. Coelho; Soudabeh Ghalamara; Débora Campos; Tânia Bragança Ribeiro; Ricardo Pereira; António S. Rodrigues; José A. Teixeira; Manuela Pintado. "Tomato Processing By-Products Valorisation through Ohmic Heating Approach". Foods (2023): https://doi.org/10.3390/foods12040818.
    10.3390/foods12040818
  3. Marta C. Coelho; Soudabeh Ghalamara; Ricardo Pereira; António S. Rodrigues; José A. Teixeira; Manuela E. Pintado. "Innovation and Winemaking By-Product Valorization: An Ohmic Heating Approach". Processes (2023): https://doi.org/10.3390/pr11020495.
    10.3390/pr11020495
  4. Catarina Silva; Miguel Machado; José Ferrão; António Sebastião Rodrigues; Luís Vieira. "Whole human genome 5’-mC methylation analysis using long read nanopore sequencing". Epigenetics (2022): https://doi.org/10.1080/15592294.2022.2097473.
    10.1080/15592294.2022.2097473
  5. Isabel S. Barata; Bruno C. Gomes; António S. Rodrigues; José Rueff; Michel Kranendonk; Francisco Esteves. "The Complex Dynamic of Phase I Drug Metabolism in the Early Stages of Doxorubicin Resistance in Breast Cancer Cells". Genes (2022): https://doi.org/10.3390/genes13111977.
    10.3390/genes13111977
  6. Marta Coelho; Carla Oliveira; Ezequiel R. Coscueta; João Fernandes; Ricardo N. Pereira; José A. Teixeira; António Sebastião Rodrigues; Manuela E. Pintado. "Bioactivity and Bioaccessibility of Bioactive Compounds in Gastrointestinal Digestion of Tomato Bagasse Extracts". Foods 11 7 (2022): 1064-1064. https://doi.org/10.3390/foods11071064.
    10.3390/foods11071064
  7. Nunes Silva, Susana; Gomes, BC; André, Saudade; Felix, Ana; Rodrigues, António Sebastião; Rueff, José. "Male and female breast cancer: the two faces of the same genetic susceptibility coin". Breast Cancer Research and Treatment 188 1 (2021): 295-305. http://dx.doi.org/10.1007/s10549-021-06159-x.
    10.1007/s10549-021-06159-x
  8. Marta Coelho; Sara Silva; Eduardo Costa; Ricardo N. Pereira; António Sebastião Rodrigues; José António Teixeira; Manuela Pintado. "Anthocyanin Recovery from Grape by-Products by Combining Ohmic Heating with Food-Grade Solvents: Phenolic Composition, Antioxidant, and Antimicrobial Properties". Molecules 26 13 (2021): 3838-3838. https://doi.org/10.3390/molecules26133838.
    10.3390/molecules26133838
  9. Marta C. Coelho; Tânia B. Ribeiro; Carla Oliveira; Patricia Batista; Pedro Castro; Ana Rita Monforte; António Sebastião Rodrigues; José Teixeira; Manuela Pintado. "In Vitro Gastrointestinal Digestion Impact on the Bioaccessibility and Antioxidant Capacity of Bioactive Compounds from Tomato Flours Obtained after Conventional and Ohmic Heating Extraction". Foods 10 3 (2021): 554-554. https://doi.org/10.3390/foods10030554.
    10.3390/foods10030554
  10. Araújo, Marília Ladeira de; Gomes, Bruno Costa; Devóz, Paula Pícoli; Duarte, Nathália de Assis Aguilar; Ribeiro, Diego Luis; Araújo, Adriana Ladeira de; Batista, Bruno Lemos; et al. "Association Between miR-148a and DNA Methylation Profile in Individuals Exposed to Lead (Pb)". Frontiers in Genetics 12 (2021): http://dx.doi.org/10.3389/fgene.2021.620744.
    10.3389/fgene.2021.620744
  11. Coelho, M.C.; Pereira, R.N.; Rodrigues, A.S.; Teixeira, J.A.; Pintado, M.E.. "The use of emergent technologies to extract added value compounds from grape by-products". Trends in Food Science & Technology 106 (2020): 182-197. http://dx.doi.org/10.1016/j.tifs.2020.09.028.
    10.1016/j.tifs.2020.09.028
  12. Brás, Aldina; Rodrigues, António; Rueff, José. "Copy number variations and constitutional chromothripsis (Review)". Biomedical Reports (2020): http://dx.doi.org/10.3892/br.2020.1318.
    10.3892/br.2020.1318
  13. Gomes, Bruno C.; Honrado, Mónica; Armada, Ana; Viveiros, Miguel; Rueff, José; Rodrigues, António S.. "ABC Efflux Transporters and the Circuitry of miRNAs: Kinetics of Expression in Cancer Drug Resistance". International Journal of Molecular Sciences 21 8 (2020): 2985. http://dx.doi.org/10.3390/ijms21082985.
    10.3390/ijms21082985
  14. Rueff, J.; Rodrigues, A.S.; Kranendonk, M.. "A personally guided tour on some of our data with the Ames assay—A tribute to Professor Bruce Ames". Mutation Research/Genetic Toxicology and Environmental Mutagenesis 846 (2019): 503094. http://dx.doi.org/10.1016/j.mrgentox.2019.503094.
    10.1016/j.mrgentox.2019.503094
  15. Rodrigues, António. "Regulation of ABCB1 activity by microRNA-200c and microRNA-203a in breast cancer cells: the quest for microRNAs’ involvement in cancer drug resistance". Cancer Drug Resistance (2019): http://dx.doi.org/10.20517/cdr.2019.24.
    10.20517/cdr.2019.24
  16. Coelho, Marta; Pereira, Ricardo; Rodrigues, António S.; Teixeira, José A.; Pintado, Manuela E.; Coelho, M.; Pereira, Ricardo Nuno Correia; Teixeira, J. A.. "Extraction of tomato by-products’ bioactive compounds using ohmic technology". (2019): http://hdl.handle.net/10400.14/28189.
    10.1016/j.fbp.2019.08.005
  17. Gomes, Bruno Costa; Rueff, José; Rodrigues, António Sebastião. "MicroRNAs and cancer drug resistance: over two thousand characters in search of a role". Cancer Drug Resistance (2019): 618-633. http://dx.doi.org/10.20517/cdr.2019.55.
    Open access • 10.20517/cdr.2019.55
  18. Célia Martins; José Rueff; António S. Rodrigues. "Genotoxic alkenylbenzene flavourings, a contribution to risk assessment". Food and Chemical Toxicology 118 (2018): 861-879. https://doi.org/10.1016/j.fct.2018.06.020.
    10.1016/j.fct.2018.06.020
  19. Lobo, Lis; Cabral, Lília I. L.; Sena, Maria Inês; Guerreiro, Bruno; Rodrigues, António Sebastião; de Andrade-Neto, Valter Ferreira; Cristiano, Maria L. S.; et al. "New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum". Malaria Journal 17 1 (2018): 145-145. https://doi.org/10.1186/s12936-018-2281-x.
    10.1186/s12936-018-2281-x
  20. Br�s, Aldina; Rodrigues, Ant�nio; Gomes, Bruno; Rueff, Jos�. "Down syndrome and microRNAs (Review)". Biomedical Reports (2017): http://dx.doi.org/10.3892/br.2017.1019.
    10.3892/br.2017.1019
  21. Kiaco, K.; Rodrigues, A. S.; do Rosario, V.; Gil, J. P.; Lopes, D.. "The drug transporter ABCB1 c.3435C>T SNP influences artemether-lumefantrine treatment outcome". Malaria Journal 16 (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000411352800002&KeyUID=WOS:000411352800002.
    10.1186/s12936-017-2006-6
  22. Coelho, Marta; Silva, Sara; Rodríguez-Alcalá, Luis Miguel; Oliveira, Ana; Costa, Eduardo M.; Borges, André; Martins, Célia; et al. "Quercus based coffee-like beverage: effect of roasting process and functional characterization". Journal of Food Measurement and Characterization (2017): https://doi.org/10.1007/s11694-017-9660-9.
    10.1007/s11694-017-9660-9
  23. D' Oliveira Martins, F.; Gomes, B. C.; Rodrigues, A. S.; Rueff, J.. "Genetic Susceptibility in Acute Pancreatitis: Genotyping of GSTM1, GSTT1, GSTP1, CASP7, CASP8, CASP9, CASP10, LTA, TNFRSF1B, and TP53 Gene Variants". Pancreas 46 1 (2017): 71-76. https://www.ncbi.nlm.nih.gov/pubmed/27984487.
    10.1097/MPA.0000000000000707
  24. Rueff, J.; Rodrigues, A. S.. "Preface". Methods Mol Biol 1395 (2016): v-vii.
  25. Goncalves, J.; Moreira, E.; Sequeira, I. J.; Rodrigues, A. S.; Rueff, J.; Bras, A.. "Integration of HIV in the Human Genome: Which Sites Are Preferential? A Genetic and Statistical Assessment". International Journal of Genomics (2016): 6-6. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000375972100001&KeyUID=WOS:000375972100001.
    10.1155/2016/2168590
  26. Martins, Marta; Baptista, Pedro V.; Mendo, Ana Soraia; Correia, Claudia; Videira, Paula Alexandra; Rodrigues, A. S.; Muthukumaran, J.; et al. "In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(IV) complex". Molecular BioSystems (2016):
    10.1039/C5MB00791G
  27. Armada, A.; Martins, C.; Spengler, G.; Molnar, J.; Amaral, L.; Rodrigues, A. S.; Viveiros, M.. "Fluorimetric Methods for Analysis of Permeability, Drug Transport Kinetics, and Inhibition of the ABCB1 Membrane Transporter". Methods Mol Biol 1395 (2016): 87-103.
    10.1007/978-1-4939-3347-1_7
  28. Gromicho, M.; Rueff, J.; Rodrigues, A. S.. "Dynamics of Expression of Drug Transporters: Methods for Appraisal". Methods Mol Biol 1395 (2016): 75-85.
    10.1007/978-1-4939-3347-1_6
  29. Rueff, J.; Rodrigues, A. S.. "Cancer Drug Resistance: A Brief Overview from a Genetic Viewpoint". Methods Mol Biol 1395 (2016): 1-18.
    10.1007/978-1-4939-3347-1_1
  30. Gomes, B. C.; Martins, M.; Lopes, P.; Morujão, I.; Oliveira, M.; Araújo, A.; Rueff, J.; Rodrigues, A. S.. "Prognostic value of microRNA-203a expression in breast cancer". Oncol Rep 36 3 (2016): 1748-56. https://www.ncbi.nlm.nih.gov/pubmed/27431784.
    10.3892/or.2016.4913
  31. Gomes, B. C.; Rueff, J.; Rodrigues, A. S.. "MicroRNAs and Cancer Drug Resistance". Methods Mol Biol 1395 (2016): 137-62.
    10.1007/978-1-4939-3347-1_9
  32. Gomes, B. C.; Santos, B.; Rueff, J.; Rodrigues, A. S.. "Methods for Studying MicroRNA Expression and Their Targets in Formalin-Fixed, Paraffin-Embedded (FFPE) Breast Cancer Tissues". Methods Mol Biol 1395 (2016): 189-205.
    10.1007/978-1-4939-3347-1_11
  33. Costa, E. M.; Silva, S.; M.R.Costa,; Pereir, M.; Campos, D. A.; Odila, J.; Madureira, A. R.; et al. "Chitosan mouthwash: Toxicity and in vivo validation". Carbohydrate Polymers 0 (2014):
    10.1016/j.carbpol.2014.04.046
  34. Martins, C.; Doran, C.; Silva, I. C.; Miranda, C.; Rueff, J.; Rodrigues, A. S.. "Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells". Chem Biol Interact (2014):
    10.1016/j.cbi.2014.04.014
  35. Luís, D.V.; Silva, J.; Tomaz, A.I.; de Almeida, R.F.M.; Larguinho, M.; Baptista, P.V.; Martins, L.M.D.R.S.; et al. "Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies". Journal of Biological Inorganic Chemistry (2014): 1-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893011558&partnerID=MN8TOARS.
    10.1007/s00775-014-1110-0
  36. Silva, Joana; Rodrigues, António Sebastião; Videira, Paula A.; Lasri, Jamal; Charmier, Adília Januário; Pombeiro, Armando J. L.; Fernandes, Alexandra R.. "Characterization of the antiproliferative potential and biological targets of a trans ketoimine platinum complex". Inorganica Chimica Acta 0 (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000345116000018&KeyUID=WOS:000345116000018.
    10.1016/j.ica.2014.07.067
  37. Rodrigues, A.; Gromicho, M.; Costa Gomes, B.; Rueff, J.. "Methylation status of selected microRNAs in imatinib-sensitive and imatinib-resistant chronic myeloid leukaemia (K562) cell lines". European Journal of Cancer 49 (2013): S122-S122. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000326843600429&KeyUID=WOS:000326843600429.
  38. Louro, A.; Peralta, L.; Soares, S.; Pereira, A.; Cunha, G.; Belchior, A.; Ferreira, L.; et al. "Human exposure to indoor radon: A survey in the region of Guarda, portugal". Radiation Protection Dosimetry 154 2 (2013): 237-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875791679&partnerID=MN8TOARS.
    10.1093/rpd/ncs166
  39. Gromicho, M.; Magalhães, M.; Torres, F.; Dinis, J.; Fernandes, A.R.; Rendeiro, P.; Tavares, P.; et al. "Instability of mRNA expression signatures of drug transporters in chronic myeloid leukemia patients resistant to imatinib". Oncology Reports 29 2 (2013): 741-750. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872768729&partnerID=MN8TOARS.
    10.3892/or.2012.2153
  40. Dinis, J.; Silva, V.; Gromicho, M.; Martins, C.; Laires, A.; Tavares, P.; Rendeiro, P.; et al. "DNA damage response in imatinib resistant chronic myeloid leukemia K562 cells". Leukemia and Lymphoma 53 10 (2012): 2004-2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865767542&partnerID=MN8TOARS.
    10.3109/10428194.2012.681654
  41. Martins, C.; Cação, R.; Cole, K.J.; Phillips, D.H.; Laires, A.; Rueff, J.; Rodrigues, A.S.. "Estragole: A weak direct-acting food-borne genotoxin and potential carcinogen". Mutation Research - Genetic Toxicology and Environmental Mutagenesis 747 1 (2012): 86-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862319232&partnerID=MN8TOARS.
    10.1016/j.mrgentox.2012.04.009
  42. Sousa, C.; Fernandes, F.; Valentão, P.; Rodrigues, A.S.; Coelho, M.; Teixeira, J.P.; Silva, S.; et al. "Brassica oleracea L. Var. costata DC and Pieris brassicae L. Aqueous extracts reduce methyl methanesulfonate-induced DNA damage in V79 hamster lung fibroblasts". Journal of Agricultural and Food Chemistry 60 21 (2012): 5380-5387. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861592201&partnerID=MN8TOARS.
    10.1021/jf300941s
  43. Rodrigues, A.S.; Dinis, J.; Gromicho, M.; Martins, C.; Laires, A.; Rueff, J.. "Genomics and cancer drug resistance". Current Pharmaceutical Biotechnology 13 5 (2012): 651-673. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860265107&partnerID=MN8TOARS.
    10.2174/138920112799857549
  44. Martins, C.; Doran, C.; Laires, A.; Rueff, J.; Rodrigues, A.S.. "Genotoxic and apoptotic activities of the food flavourings myristicin and eugenol in AA8 and XRCC1 deficient EM9 cells". Food and Chemical Toxicology 49 2 (2011): 385-392. http://www.scopus.com/inward/record.url?eid=2-s2.0-78951490635&partnerID=MN8TOARS.
    10.1016/j.fct.2010.11.013
  45. Gromicho, M.; Dinis, J.; Magalhães, M.; Fernandes, A.R.; Tavares, P.; Laires, A.; Rueff, J.; Rodrigues, A.S.. "Development of imatinib and dasatinib resistance: Dynamics of expression of drug transporters ABCB1, ABCC1, ABCG2, MVP, and SLC22A1". Leukemia and Lymphoma 52 10 (2011): 1980-1990. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053211502&partnerID=MN8TOARS.
    10.3109/10428194.2011.584005
  46. Gómez-Bombarelli, R.; Palma, B.B.; Martins, C.; Kranendonk, M.; Rodrigues, A.S.; Calle, E.; Rueff, J.; Casado, J.. "Alkylating potential of oxetanes". Chemical Research in Toxicology 23 7 (2010): 1275-1281. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955359925&partnerID=MN8TOARS.
    10.1021/tx100153w
  47. Silva, F.; Marques, F.; Santos, I.C.; Paulo, A.; Rodrigues, A.S.; Rueff, J.; Santos, I.. "Synthesis, characterization and cytotoxic activity of gallium(III) complexes anchored by tridentate pyrazole-based ligands". Journal of Inorganic Biochemistry 104 5 (2010): 523-532. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950691262&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2010.01.003
  48. Rodrigues, António. "99mTc-Tricarbonyl Complexes Functionalized with Anthracenyl Fragments: Synthesis, Characterization, and Evaluation of Their Radiotoxic Effects in Murine Melanoma Cells". Cancer Biotherapy & Radiopharmaceuticals (2009): http://online.liebertpub.com/doi/abs/10.1089/cbr.2009.0647.
    10.1089/cbr.2009.0647
  49. Gromicho, L.; Dinis, J.; Martins, C.; Laires, A.; Rueff, J.; Rodrigues, A.. "ROLE OF ABC TRANSPORTERS IN THE DEVELOPMENT OF IMATINIB RESISTANCE". Haematologica-the Hematology Journal 94 (2009): 344-345. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000266931900853&KeyUID=WOS:000266931900853.
  50. Monteiro, Margarida; Rodrigues, Antonio S.; Vicente, Ana; Murias, Jose; Martins, Celia; Rueff, Jose; Borba, Helena. "Oxidative DNA damage induced by potassium bromate in repair proficient and deficient CHO cell lines". Free Radical Research 41 (2007): S42-S42. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252296300153&KeyUID=WOS:000252296300153.
  51. Maralhas, A.; Monteiro, A.; Martins, C.; Kranendonk, M.; Laires, A.; Rueff, J.; Rodrigues, A.S.. "Genotoxicity and endoreduplication inducing activity of the food flavouring eugenol". Mutagenesis 21 3 (2006): 199-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745113204&partnerID=MN8TOARS.
    10.1093/mutage/gel017
  52. Rodrigues, A.S.; Oliveira, N.G.; Gil, O.M.; Léonard, A.; Rueff, J.. "Use of cytogenetic indicators in radiobiology". Radiation Protection Dosimetry 115 1-4 (2005): 455-460. http://www.scopus.com/inward/record.url?eid=2-s2.0-30844454027&partnerID=MN8TOARS.
    10.1093/rpd/nci072
  53. Goulart, M.; Batoréu, M.C.; Rodrigues, A.S.; Laires, A.; Rueff, J.. "Lipoperoxidation products and thiol antioxidants in chromium exposed workers". Mutagenesis 20 5 (2005): 311-315. http://www.scopus.com/inward/record.url?eid=2-s2.0-24044544600&partnerID=MN8TOARS.
    10.1093/mutage/gei043
  54. Oliveira, N.G.; Castro, M.; Rodrigues, A.S.; Gonçalves, I.C.; Martins, C.; Toscano Rico, J.M.; Rueff, J.. "Effect of poly(ADP-ribosyl)ation inhibitors on the genotoxic effects of the boron neutron capture reaction". Mutation Research - Genetic Toxicology and Environmental Mutagenesis 583 1 (2005): 36-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-18144404643&partnerID=MN8TOARS.
    10.1016/j.mrgentox.2005.01.015
  55. Medeiros, MG; Rodrigues, AS; Batoreu, MC; Laires, A; Zhitkovich, A; Rueff, J; Rodrigues, António Sebastião. "Biomarkers of chromium exposure and cytogenetic damage in leather tanning and welding industry workers". NATO SCIENCE SERIES SUB SERIES I LIFE AND BEHAVIOURAL SCIENCES 351 (2003): 132-141.
  56. Medeiros, M.G.; Rodrigues, A.S.; Batoréu, M.C.; Laires, A.; Rueff, J.; Zhitkovich, A.. "Elevated levels of DNA -protein crosslinks and micronuclei in peripheral lymphocytes of tannery workers exposed to trivalent chromium". Mutagenesis 18 1 (2003): 19-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037237911&partnerID=MN8TOARS.
    10.1093/mutage/18.1.19
  57. Oliveira, N.G.; Castro, M.; Rodrigues, A.S.; Gonçalves, I.C.; Gil, O.M.; Fernandes, A.P.; Toscano-Rico, J.M.; Rueff, J.. "Wortmannin enhances the induction of micronuclei by low and high LET radiation". Mutagenesis 18 1 (2003): 37-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037236752&partnerID=MN8TOARS.
    10.1093/mutage/18.1.37
  58. Oliveira, N.G.; Castro, M.; Rodrigues, A.S.; Conçalves, I.C.; Gil, O.M.; Fernandes, A.P.; Toscano-Rico, J.M.; Rueff, J.. "Erratum: Wortmannin enhances the induction of micronuclei by low and high LET radiation (Mutagenesis (2003) vol. 18 (37-44))". Mutagenesis 18 2 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-0037340911&partnerID=MN8TOARS.
    10.1093/mutage/18.2.217
  59. Gil, O.M.; Oliveira, N.G.; Rodrigues, A.S.; Laires, A.; Ferreira, T.C.; Limbert, E.; Rueff, J.. "Possible transient adaptive response to mitomycin C in peripheral lymphocytes from thyroid cancer patients after iodine-131 therapy". International Journal of Cancer 102 6 (2002): 556-561. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037146755&partnerID=MN8TOARS.
    10.1002/ijc.10768
  60. Oliveira, N.G.; Castro, M.; Rodrigues, A.S.; Gil, O.M.; Toscano-Rico, J.M.; Rueff, J.. "DNA-PK inhibitor wortmannin enhances DNA damage induced by bleomycin in V79 Chinese hamster cells". Teratogenesis Carcinogenesis and Mutagenesis 22 5 (2002): 343-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036025187&partnerID=MN8TOARS.
    10.1002/tcm.10029
  61. Oliveira, N.G.; Castro, M.; Rodrigues, A.S.; Gonçalves, I.C.; Cassapo, R.; Fernandes, A.P.; Chaveca, T.; Toscano-Rico, J.M.; Rueff, J.. "Evaluation of the genotoxic effects of the boron neutron capture reaction in human melanoma cells using the cytokinesis block micronucleus assay". Mutagenesis 16 5 (2001): 369-375. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034821293&partnerID=MN8TOARS.
  62. Gil, O.M.; Oliveira, N.G.; Rodrigues, A.S.; Laires, A.; Ferreira, T.C.; Limbert, E.; Léonard, A.; Gerber, G.; Rueff, J.. "Cytogenetic alterations and oxidative stress in thyroid cancer patients after iodine-131 therapy". Mutagenesis 15 1 (2000): 69-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342545858&partnerID=MN8TOARS.
  63. Duarte Silva, I.; Gaspar, J.; Gomes Da Costa, G.; Rodrigues, A.S.; Laires, A.; Rueff, J.. "Chemical features of flavonols affecting their genotoxicity. Potential implications in their use as therapeutical agents". Chemico-Biological Interactions 124 1 (2000): 29-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033990797&partnerID=MN8TOARS.
    10.1016/S0009-2797(99)00139-8
  64. Gil, O.M.; Oliveira, N.G.; Rodrigues, A.S.; Laires, A.; Ferreira, T.C.; Limbert, E.; Rueff, J.. "No evidence of increased chromosomal aberrations and micronuclei in lymphocytes from nonfamilial thyroid cancer patients prior to radiotherapy". Cancer Genetics and Cytogenetics 123 1 (2000): 55-60. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033673797&partnerID=MN8TOARS.
    10.1016/S0165-4608(00)00305-8
  65. Alves, I.; Oliveira, N.G.; Laires, A.; Rodrigues, A.S.; Rueff, J.. "Induction of micronuclei and chromosomal aberrations by the mycotoxin patulin in mammalian cells: Role of ascorbic acid as a modulator of patulin clastogenicity". Mutagenesis 15 3 (2000): 229-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034067139&partnerID=MN8TOARS.
  66. Oliveira, N.G.; Neves, M.; Rodrigues, A.S.; Gil, O.M.; Chaveca, T.; Rueff, J.. "Assessment of the adaptive response induced by quercetin using the MNCB peripheral blood human lymphocytes assay". Mutagenesis 15 1 (2000): 77-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033960395&partnerID=MN8TOARS.
  67. Oliveira, N.G.; Rodrigues, A.S.; Chaveca, T.; Rueff, J.. "Induction of an adaptive response to quercetin, mitomycin C and hydrogen peroxide by low doses of quercetin in V79 Chinese hamster cells". Mutagenesis 12 6 (1997): 457-462. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030781119&partnerID=MN8TOARS.
  68. Duarte Silva, I.; Rodrigues, A.S.; Gaspar, J.; Laires, A.; Rueff, J.. "Metabolism of galangin by rat cytochromes P450: Relevance to the genotoxicity of galangin". Mutation Research - Genetic Toxicology and Environmental Mutagenesis 393 3 (1997): 247-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030727025&partnerID=MN8TOARS.
    10.1016/S1383-5718(97)00109-5
  69. Duarte Silva, I.; Rodrigues, A.S.; Gaspar, J.; Maia, R.; Laires, A.; Rueff, J.. "Involvement of rat cytochrome 1A1 in the biotransformation of kaempferol to quercetin: Relevance to the genotoxicity of kaempferol". Mutagenesis 12 5 (1997): 383-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030773207&partnerID=MN8TOARS.
    10.1093/mutage/12.5.383
  70. Duarte Silva, I.; Gaspar, J.; Rodrigues, A.; Gomes da Costa, G.; Laires, A.; Rueff, J.. "Mechanisms of myricetin mutagenicity in V79 cells: Involvement of radicalar species". Teratogenesis Carcinogenesis and Mutagenesis 16 5 (1996): 253-268. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030421113&partnerID=MN8TOARS.
    10.1002/(SICI)1520-6866(1996)16:5<253::AID-TCM2>3.0.CO;2-H
  71. Duarte Silva, I.; Rodrigues, A.; Gaspar, J.; Maia, R.; Laires, A.; Rueff, J.. "Mutagenicity of kaempferol in V79 cells: The role of cytochromes P450". Teratogenesis Carcinogenesis and Mutagenesis 16 4 (1996): 229-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030483889&partnerID=MN8TOARS.
    10.1002/(SICI)1520-6866(1996)16:4<229::AID-TCM4>3.0.CO;2-K
  72. Rueff, J.; Chiapella, C.; Chipman, J.K.; Darroudi, F.; Duarte Silva, I.; Duverger-Van Bogaert, M.; Fonti, E.; et al. "Development and validation of alternative metabolic systems for mutagenicity testing in short-term assays". Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 353 1-2 (1996): 151-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029941363&partnerID=MN8TOARS.
    10.1016/0027-5107(95)00246-4
  73. Rodrigues, A.S.; Duarte Silva, I.; Caria, M.H.; Laires, A.; Chaveca, T.; Glatt, H.R.; Rueff, J.. "Genotoxicity assessment of aromatic amines and amides in genetically engineered V79 cells". Mutation Research - Genetic Toxicology 341 2 (1994): 93-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027984133&partnerID=MN8TOARS.
    10.1016/0165-1218(94)90091-4
  74. Gaspar, J.; Rodrigues, A.; Laires, A.; Silva, F.; Costa, S.; Monteiro, M.J.; Monteiro, C.; Rueff, J.. "On the mechanisms of genotoxicity and metabolism of quercetin". Mutagenesis 9 5 (1994): 445-449. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028136463&partnerID=MN8TOARS.
  75. Rueff, J.; Rodrigues, A.; Laires, A.; Gaspar, J.. "Activation of promutagens by porphyrinic biomimetic systems". Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 269 2 (1992): 243-250. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026675201&partnerID=MN8TOARS.
    10.1016/0027-5107(92)90206-H
  76. Rueff, J.; Laires, A.; Gaspar, J.; Borba, H.; Rodrigues, A.. "Oxygen species and the genotoxicity of quercetin". Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 265 1 (1992): 75-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026792730&partnerID=MN8TOARS.
    10.1016/0027-5107(92)90040-9
  77. Gaspar, J.; Monteiro, M.; Rueff, J.; Laires, A.; Laureano, O.; Rodrigues, A.. "FACTORS INVOLVED IN THE MUTAGENICITY DURING THE VINIFICATION OF RED WINES FROM DIFFERENT ORIGINS". Mutation Research 271 2 (1992): 171-171.
    10.1016/0165-1161(92)91218-g
  78. Rueff, J.; Laires, A.; Gaspar, J.; Rodrigues, A.. "Mutagenic activity in the wine-making process: Correlations with rutin and quercetin levels". Mutagenesis 5 4 (1990): 393-396. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024996903&partnerID=MN8TOARS.
  79. Laires, A.; Rueff, J.; Gaspar, J.; Rodrigues, A. S.. "MUTAGENIC ACTIVITY IN ALCOHOLIC FERMENTATION". Mutation Research 203 3 (1988): 238-239. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1988N788900089&KeyUID=WOS:A1988N788900089.
    10.1016/0165-1161(88)90187-2

Other

Other output
  1. Motor dysfunction in Drosophila melanogaster as a biomarker for developmental neurotoxicity. 2021. Ana Cabrita; Alexandra M. Medeiros; Telmo Pereira; António Sebastião Rodrigues; Michel Kranendonk; César S. Mendes. https://doi.org/10.1101/2021.07.09.451676.
    10.1101/2021.07.09.451676
  2. Whole human genome 5’-mC methylation analysis using long read nanopore sequencing. 2021. Catarina Silva; Miguel Machado; José Ferrão; Sebastião Rodrigues; Luís Vieira. https://doi.org/10.1101/2021.05.20.444035.
    10.1101/2021.05.20.444035
  3. Down syndrome and microRNAs.. 2017. Brás, A.; Rodrigues, A. S.; Gomes, B.; Rueff, J..
    10.3892/br.2017.1019
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/07/17 - Current Aplicação combinada de metodologias de sequenciação para o estudo de casos de patologia genética com etiologia molecular desconhecida
Co-supervisor
 Biomedicina (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Aveiro, Portugal
2021/09/01 - 2023/03/15 Protein Glycosylation in Cancer Drug Resistance
Supervisor
 Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/09/07 - 2022 Role of microRNAs in cancer drug resistance
Supervisor
 Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015/02/03 - 2021/12/20 Ohmic-Heating Treatment as a New Process for Development of Functional Ingredients Through Valorisation of Tomato and Grape by-Products
Co-supervisor
 Ciência e Tecnologia Alimentar e Nutrição (PhD)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2019 - 2021/04/15 Assessment of microRNAs as biomarkers of disease progression in amyotrophic lateral sclerosis
Co-supervisor
 Biochemistry for Health (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/09/01 - 2021/03/26 Influence of microRNAs on cancer drug resistance
Supervisor
 Biochemistry for Health (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2020 Influence of microRNAs on cancer drug resistance
Supervisor
 Master in Molecular Genetics and Biomedicine (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2019 Modulation of ABC transporters in multidrug resistance (MDR): From prokaryotic to eukaryotic cells
Co-supervisor
 Doutoramento em Ciências Biomédicas (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - 2017 Study of the Natural Alkenylbenzenes Compounds: Mechanisms of DNA Lesion and Implications for Human Health
Supervisor
 Doutoramento em Ciências da Vida (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010 - 2016 MicroRNA involvement in breast cancer susceptibility and progression
Supervisor
 Doutoramento em Ciências da Vida (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2013 - 2014 Immunohistochemistry detection of putative miR-200c and miR-203 Targets in Breast Cancer Patients
Supervisor
 Master in Molecular Genetics and Biomedicine (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2014 Alteração da metilação do DNA após exposição prolongada a fitoquímicos
Co-supervisor
 Master in Molecular Genetics and Biomedicine (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008 - 2014 Resistance to Imatinib treatment in Chronic Mieloid Leukemia: characterization of the mechanisms involved
Supervisor
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2009 - 2011 Evaluation of the DNA lesion profile and their repair in leukemic cells, sensitive and resistant to the drug Imatininb
Supervisor
 Master in Molecular Genetics and Biomedicine (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1998 - 1999 Development of metabolically competent Escherichia Coli strains for mutagenicity tests: heterologous expression of human cytochromes P450
Supervisor
 Master in Molecular Biology (Master)
Universidade Nova de Lisboa, Portugal
1998 - 1999 Study of the structure activity relationship in the induction of adaptive responses by phenolic compounds in V79 cells
Supervisor
 Master in Molecular Biology (Master)
Universidade Nova de Lisboa, Portugal
1995 - 1998 Avaliação da Resposta Adaptativa induzida pela quercetina em células eucariotas
Co-supervisor
 Mestrado em Controlo de Qualidade e Toxicologia dos Alimentos (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/12/11 The role of extracellular vesicles in chemotherapy resistance mediated by the breast cancer-liver axis
President of the jury
 Carolina Severo Ramos (Master)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023/12/06 Beating primary ciliary dyskinesia
President of the jury
 Beatriz Alexandra Adrião Salvado (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/12/06 Role of lysosome exocytosis in breast cancer progression
President of the jury
 Isabel de Sousa Sesifredo (Master)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023/12/05 Age-related Macular Degeneration, Retinal pigmented epithelium, Photoreceptors, Oxidative Stress, NRF2, KEAP1, Natural Small Molecules, Electrophiles and Protein-protein interaction inhibitors.
President of the jury
 Margarida Isabel Lopes Pedro (Master)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023/11/12 The role of the cytochrome P450-enzyme complex protein factors and other oxidoreductases in the mechanisnms of acquired cancer drug resistance
President of the jury
 Daniel Filipe Grilo Crispim (Master)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023/06/06 Advancing the understanding of Congenital Disorders of Glycosylation symptoms to accelerate therapies
President of the jury
 Madalena Romão Parrado (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/04/04 PHENYLALANINE HYDROXYLASE (PAH) ENZYMOSOMES: DEVELOPMENT OF A NANOSYSTEM FOR ENZYME SUBSTITUTION/REPLACEMENT THERAPIES
President of the jury
 Mafalda Vaz Francisco (Master)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2022/04/28 Dissecting the differential molecular signature in patients from African-origin with Triple-Negative Breast Cancer
(Thesis) Arguer
 Ana Teresa de Sousa e Menezes Matias (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/04/13 Anti-inflammatory activity of berries-driven polyphenols in zebrafish larvae fed with oxidized lipids
President of the jury
 Luís Filipe Martins Bento (Master)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2022/03/24 Non-invasive Profile of Embryo Culture Media as a Preimplantation Genetic Diagnosis for Aneuploidy
President of the jury
 Cassandra Francelina Sousa Santos (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/07/29 Desenvolvimento e validação do ensaio de mutagenicidade em células de mamífero, Mouse Linfoma Assay
(Thesis) Main arguer
 Vanessa Alexandra Ferreira Francisco (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/07/13 Unveiling paracrine dissemination and toxicity of neuronal TrkB-ICD via secretome signalling in Alzheimer’s disease
President of the jury
 Tiago Rodrigo da Costa Coelho (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/02/17 TRANSLATING BREAST CANCER IMMUNE FEATURES INTO BIOMARKERS AND THERAPIES
Thesis Member
 Diana Isabel Pereira Saraiva (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/12/23 Mecanismos de genotoxicidade de nanopartículas
(Thesis) Arguer
 Ana Filomena Aurélio Marques (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/12/10 Impacto de Impurezas Genotóxicas na Indústria Farmacêutica
(Thesis) Main arguer
 Diogo Filipe Rodrigues Felício (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/10/28 Análise molecular de genes implicados no desenvolvimento sexual do Homem por Sequenciação de Nova Geração
(Thesis) Main arguer
 Beatriz Alexandra Paninho Oliveira (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020 Role of redox-active SOD mimics on the migration and invasion capabilities of human breast cancer cells
(Thesis) Arguer
 Ana Catarina dos Santos Flórido (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 Inhibition of the redox function of APE1 as a potential strategy to improve effciacy of cisplatin in non-small cell lung cancer cells
(Thesis) Arguer
 Rita Catarina Álvaro Manguinhas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 Characterization of biological and metabolic responses to pH changes in a commensal Staphylococcus epidermidis strain
President of the jury
 Susana Isabel Duarte Santos (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019 Desenvolvimento de um teste de neurotoxicidade em Drosophila melanogaster
President of the jury
 Ana Sofia Costa Cabrita (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 Establishment of bioengineered glucose-responsive nanoparticles for type 2 diabetes mellitus therapy
President of the jury
 Filipa Ribeiro da Fonseca (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019 Long-term hypercaloric diet consumption exacerbates age-induced metabolic dysfunction: beneficial effects of CSN denervation
President of the jury
 Cláudia Alexandra Canhoto Batista (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 Drosophila Models of Neuromuscular Disorders: From Morphology to Behavior
President of the jury
 Ana Cristina Coelho Fernandes (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 Evaluation of the role of LRP1B in the response of human ovarian cancer cells to liposomal doxorubicin
President of the jury
 Inês de Andrade Matos Gonçalves Saraiva (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 Elucidating the role of synucleins in retinal neurodegeneration in Parkinson’s Disease, Diabetes and Ageing
President of the jury
 Luís Miguel Antunes de Sousa (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 In vivo mechanisms of synaptic bouton formation: Dissecting the role of the exocyst
President of the jury
 Marta Contreiras da Silva (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 Characterization of a DAND P.R152H Controlo-Derived IPS Cell Line to be used as a tool for heart disease modeling
President of the jury
 Selin Pars (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 Link Between Viral Infection and autoimmunity in Primary Sjogren’s syndrome: Clues from lymphoctic profile and ebv antibodies
President of the jury
 Ricardo Luís Carvalho Monteiro (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 HIV-1 Infection on Follicular Helper T Cells
President of the jury
 Ana Raquel Lourenço de Sousa (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 Modulation of Carotid Body Activity to treat Obesity
President of the jury
 Miguel Carvalho Ravasco Milhano Correia (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 MicroRNA involvement in breast cancer susceptibility and progression
Supervisor
 Bruno Costa Gomes (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 Modulation of human apurinic/apyrimidinic endonuclease 1 (APE1) functions for breast cancer therapy
(Thesis) Arguer
 Patrícia Isabel da Silva Guerreiro (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 Study of the Natural Alkenylbenzenes Compounds: Mechanisms of DNA Lesion and Implications for Human Health
Supervisor
 Célia Maria da Silva Martins (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 Effects on migration of breast cancer cells in 3D models upon MMP inhibition
(Thesis) Arguer
 Susana Duarte Lopes Mascarenhas Proença (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 The role of the Ral/Exocyst pathway in structural plasticity at the Drosophila Neuromuscular Junction
President of the jury
 José Pedro Dias Cristóvão (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 Crosslinked Hyaluronic acid nanoparticles as delivery vehicles for dendritic cell-targeted vacines
President of the jury
 Nuno José Prego Ramos (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 Deflamin bioactivities-A novel inhibitory protein of MMP-9 from Lupinus albus
President of the jury
 Joana Patrícia Mota Guerreiro (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 Cyto- and Genotoxicity Assessment of Manufactured Nanomaterials in the A549 Cell Line
(Thesis) Arguer
 Andreia Sofia Ferreira Saruga (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 Unravelling the role of alfa 2,6 sialic acido on mouse dendritic cells functions
President of the jury
 Leonor Nunes Rodrigues (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 Non-cell autonomous neuroprotective effect of carbon monoxide: microglia-to-neuron communication
President of the jury
 Nuno Ricardo Lucas Soares (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 Understanding how dendritic cell glycans afect antitumor imune responses
President of the jury
 Márcia Figueiredo Gonçalves (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 Osteoclatogenesis, inflammatory cytokines and biomarkers of boné metabolisms in psoriatic arthritis
President of the jury
 Soraia Patrícia Caetano da Silva (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 Contribution to Fundamental Aspects of Biophysics, Radiobiology, and Modelling of Cellular Response to Low Radiation Doses
Thesis Member
 Ana Lúcia Vital Belchior (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 “Caraterização de Propriedades Nutricionais e Antioxidantes de Chás do Arquipélago dos Açores e Valorização dos seus Resíduos
Thesis Member
 Maria Alexandra Marques Martins Campos (PhD)
2014 Atividade de antimaláricos mediada por bombas de efluxo em Plasmodium falciparum
(Thesis) Main arguer
 Sílvia Marisa Carneiro Gomes Pereira (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2013 Mecanismos de Nitrosación de sustratos complejos bioactivos
Thesis Member
 Mário Ganzález Jímenez (PhD)
Universidad de Salamanca, Spain
2013 Avaliação do Efeito da Digestão in vitro na Capacidade Antioxidante de Infusões Medicinais: Flor de Camomila e Flor de Laranjeira
(Thesis) Arguer
 Raquel Beirão Antunes (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 Rastreamento de mutações somáticas do gene EGFR de pacientes com CPNPC
(Thesis) Arguer
 Pedro Miguel Alcobia Lança Piedade Penedo (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 Desenvolvimento de um blend de café com potencial impacte positivo para a saúde pública
(Thesis) Arguer
 Vânia Sofia Santos Ribeiro (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 Caracterização do perfil de expressão de microRNAs na Miocardiopatia Hipertrófica
(Thesis) Main arguer
 Ana Cláudia Nunes (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 Avaliação da actividade antioxidante antimutagénica de diferentes infusões medicinais: Alfazema, Cavalinha, Perpétuas roxas e Príncipe
(Thesis) Arguer
 Verónica Eveline Andrade Fernandes (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 Avaliação da Lesão Genética Induzida por Exposição a Radiação Ionizante na População Portuguesa
(Thesis) Arguer
 Ana Catarina Monteiro Dias Antunes (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 Avaliação da biodisponibilidade de compostos antioxidantes em variedades de maçã produzidas em Portugal.
(Thesis) Main arguer
 Sheila Ferreira Lemos (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 Transplante alogénico de progenitores hematopoiéticos-estudo dos factores associados à doença do enxerto contra o hospedeiro no contexto Português
(Thesis) Main arguer
 36. Ana Sofia Fonseca Ramos (Master)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2011 Optimization of low human serum umbilical cord matrix mesenchymal stem cell (ucmMSC) culture for conditioned media preparation: In vitro and in vivo would healing applications
(Thesis) Main arguer
 Elysse Cebola Filipe (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011 Caracterização do efeito anti-tumoral de complexos organometálicos contendo 1,10-fenantrolina-5,6-diona
(Thesis) Main arguer
 Daniel Vieira Alves Luís (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 Complexos de Escorpionato: Papel Biológico como Potenciais Agentes Anti-Tumor
(Thesis) Main arguer
 Kelly Veiga (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 Avaliação das Propriedades Antimutagénicas de Diversos Tipos de Mel Produzido em Portugal
(Thesis) Main arguer
 Ariana Suelene Brito Soares (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010 Biological activity of well defined hydantoin derivatives on efflux pump systems of bacteria and cancer cells
(Thesis) Arguer
 Miguel José Simas do Rosário Evaristo (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2010 Exposição profissional a fumo de tabaco: Efeitos genotóxicos e influência de polimorfismos em genes de reparação do DNA
(Thesis) Main arguer
 Susana do Carmo Grilo Antunes (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008 Carcinoma da Tiróide: Catacterização Genética e Citogenética de uma População de Doentes
Thesis Member
 Octávia Gabriela da Silva Viegas Nené Monteiro Gil (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2006 Cell death mechanisms in the retina of Drosophila melanogaster
Thesis Member
 César Miguel Pereira Soares Mendes (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2004 Analysis of Dscam and its Molecular Diversity in Axonal Targeting of Olfactory Receptor Neurons in Drosophila
Thesis Member
 Maria Luísa Caramalho Abrunhosa Vasconcelos (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2003 Genotoxicity of Cromium compounds- comparative study in leather tanning and stainless steel welding industry workers
(Thesis) Arguer
 Margarida Goulart de Medeiros (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
1997 Estudo da sensibilidade a Agentes genotóxicos na Trissomia do cromossoma 21
Thesis Member
 Maria Helena Figueiredo Ramos Caria (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal