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Joaquim Rui Rodrigues graduated in Biochemistry at the University of Coimbra (UC) in 1995. After a short period of secondary school teaching, he returned to UC, serving as NMR laboratory technician and research assistant from 1997 to 2004, where he collaborated in several research projects using NMR spectroscopy and molecular dynamics simulations to study the behavior of proteins in solution. In 2004, he joined the Dep. of Environmental Engineering, School of Technology and Management, Polytechnic Institute of Leiria (ESTG/IPL) where he engaged in an ongoing project in environmental technology using alginate as a metal ions sorbent. In 2007, he earned an on-leave license from ESTG to pursue his PhD in Biomedical Research and Biotechnology, at the University of Extremadura, Spain, in the field of enzymology, focusing on the study of two enzymes, ADPRibase-Mn and triokinase/FMN cyclase. He returned to teaching at ESTG in 2011 and finished his PhD thesis in 2013. He is currently Adjunct Professor, teaching at both ESTG and School of Health Sciences (ESS/IPL), and an Integrated Member of LSRE-LCM since January 2018.
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Identification

Personal identification

Full name
Joaquim Rui de Castro Rodrigues

Citation names

  • Rodrigues, Joaquim
  • Joaquim Rui Rodrigues
  • J. R. Rodrigues
  • J. Rui Rodrigues

Author identifiers

Ciência ID
9018-0B83-E2C6
ORCID iD
0000-0002-9756-1124
Researcher Id
L-4137-2014
Scopus Author Id
10242931100

Addresses

  • Instituto Politécnico de Leiria. Morro do Lena - Alto do Vieiro, 2411-901, Leiria, Leiria, Portugal (Professional)

Websites

  • https://lsre-lcm.fe.up.pt/person/254 (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Advanced (C1) Advanced (C1) Beginner (A1) Advanced (C1)
Spanish; Castilian Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
Education
Degree Classification
2013
Concluded
 Biomedical Research and Biotechnology (Doutoramento)
Universidad de Extremadura, Spain
"Estudio de las actividades y los centros activos de las enzimas ADPRibasa-Mn y Trioquinasa/FMN ciclasa" (THESIS/DISSERTATION)
 "sobresaliente cum laude"
1995
Concluded
 Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"O Uso de Quelatos de Gadolínio no Estudo da Superfície de Proteínas" (THESIS/DISSERTATION)
 Bom (14 valores)
Affiliation

Science

Category
Host institution 		Employer
2018/01/01 - Current Researcher (Research) Universidade do Porto Laboratório de Processos de Separação e Reacção Laboratório de Catálise e Materiais, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2013/09/30 - Current Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Leiria Escola Superior de Tecnologia e Gestão, Portugal
2004/09/15 - 2013/09/29 Assistant (Polytechnic Teacher) Instituto Politécnico de Leiria Escola Superior de Tecnologia e Gestão, Portugal

Others

Category
Host institution 		Employer
2007/02/05 - 2011/08/31 PhD Student Universidad de Extremadura, Spain
2002/01/01 - 2004/08/31 Research assistant fellowship Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2000/01/01 - 2001/12/31 Laboratory technician Universidade de Coimbra Departamento de Química, Portugal
1999/01/01 - 1999/12/31 Research scholarship Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1997/01/01 - 1998/12/31 NMR laboratory technician Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1996/09/01 - 1996/12/31 Chemistry high-school teacher Escola Secundária de Monserrate, Portugal
Projects

Grant

Designation Funders
2018/10 - 2022/09 Sistemas biomoleculares multifuncionais para novos métodos de descontaminação, proteção e avaliação toxicológica
Provided by PTCRIS: PTDC/BIA-MIB/31864/2017
 Fundação para a Ciência e a Tecnologia
1999/01 - 1999/12 DINÂMICA MOLECULAR NO MUTANTE C24T DA PROTEÍNA INTERLEUCINA-4 - MESTRADO EM ENGENHARIA BIOMÉDICA
Provided by PTCRIS: PRAXIS XXI/BM/17660/98
 Fundação para a Ciência e a Tecnologia
1997/01 - 1998/12 FORMAÇÃO ESPECIALIZADA EM RMN E OPERAÇÃO DE ESPECTRÓMETRIA RMN DE CAMPO ALTO VARIAN UNITY 500
Provided by PTCRIS: PRAXIS XXI/BTL/7418/96
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2021/01/01 - 2025/12/31 ALICE - Laboratório Associado em Engenharia Química
10.54499/LA/P/0045/2020
LA/P/0045/2020
LA/P/0045/2020
Universidade do Porto Laboratório de Processos de Separação e Reacção Laboratório de Catálise e Materiais, Portugal

Instituto Politécnico de Leiria, Portugal

Universidade do Porto Centro de Estudos de Fenómenos de Transporte, Portugal

Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia
UIDB/00511/2020
10.54499/UIDB/00511/2020
Universidade do Porto Laboratório de Processos de Separação e Reacção Laboratório de Catálise e Materiais, Portugal

Instituto Politécnico de Leiria, Portugal

Universidade do Porto Centro de Estudos de Fenómenos de Transporte, Portugal

Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/03 - 2022/09/30 MBStox - Multifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
PTDC/BIA-MIB/31864/2017
Instituto Politécnico de Leiria Escola Superior de Tecnologia e Gestão, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Marques-Da-Silva, D.; Rodrigues, J.R.; Lagoa, R.; Marques-da-Silva, Dorinda; Rodrigues, Joaquim Rui; Lagoa, Ricardo. "Anthocyanins, effects in mitochondria and metabolism". In Mitochondrial Physiology and Vegetal Molecules, 267-300. Elsevier, 2021.
    Published • 10.1016/b978-0-12-821562-3.00028-9
  2. Lagoa, Ricardo; Rodrigues, Joaquim Rui. "Biodiversidade, as Biotecnologias e a procura de uma nova Bioeconomia". 2016.
  3. Rodrigues, J.R.; Brito, R.M.M.. "How important is the role of compact denatured states on amyloid formation by transthyretin?". 323-325. 2004.
Conference paper
  1. Lagoa, Ricardo; Vanat, Pavlo; Ferreira, Stefanie; Silva, João; Marques-da-Silva, Dorinda; Ribeiro, Vânia; Vaz, Daniela C.; Barreiros, Fátima; Rodrigues, Joaquim Rui. "Alginate films encapsulating polyphenols for nutraceutical and biomedical applications". 2017.
  2. Manso, João; Silva, Rui; Rodrigues, Joaquim Rui; Lagoa, Ricardo. "Modelling of metal recovery from industrial wastewater using a biopolymer sorbent". 2007.
  3. Stahl, F.; Berrar, D.; Silva, C.; Rodrigues, J.R.; Brito, R.M.M.; Dubitzky, W.. "Grid warehousing of molecular dynamics protein unfolding data". 2005.
    10.1109/CCGRID.2005.1558594
  4. Rodrigues, Joaquim. "Detection of hydrophobic clusters in molecular dynamics protein unfolding simulations using association rules". 2005.
    doi.org/10.1007/11573067_33
  5. Rodrigues, Joaquim Rui; Lagoa, Ricardo. "Kinetic studies of alginate gelation". 2005.
Journal article
  1. Daniela C. Vaz; J. Rui Rodrigues; Nuno Loureiro-Ferreira; Thomas D. Müller; Walter Sebald; Christina Redfield; Rui M. M. Brito. "Lessons on protein structure from interleukin-4: All disulfides are not created equal". Proteins: Structure, Function, and Bioinformatics (2023): https://doi.org/10.1002/prot.26611.
    10.1002/prot.26611
  2. Cabezas, A.; Costas, M.J.; Canales, J.; Pinto, R.M.; Rodrigues, J.R.; Ribeiro, J.M.; Cameselle, J.C.. "Enzyme Characterization of Pro-virulent SntA, a Cell Wall-Anchored Protein of Streptococcus suis, With Phosphodiesterase Activity on cyclic-di-AMP at a Level Suited to Limit the Innate Immune System". Frontiers in Microbiology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85128243838&partnerID=MN8TOARS.
    10.3389/fmicb.2022.843068
  3. Iralis López-Villamizar; Alicia Cabezas; Rosa María Pinto; José Canales; João Meireles Ribeiro; Joaquim Rui Rodrigues; María Jesús Costas; José Carlos Cameselle. "Molecular Dissection of Escherichia coli CpdB: Roles of the N Domain in Catalysis and Phosphate Inhibition, and of the C Domain in Substrate Specificity and Adenosine Inhibition". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22041977.
    10.3390/ijms22041977
  4. Onoufriadis, A.; Cabezas, A.; Ng, J.C.F.; Canales, J.; Costas, M.J.; Ribeiro, J.M.; Rodrigues, Joaquim; et al. "Autosomal recessive hypotrichosis with loose anagen hairs associated with TKFC mutations*". British Journal of Dermatology 184 5 (2020): 935-943. http://dx.doi.org/10.1111/bjd.19481.
    10.1111/bjd.19481
  5. João Silva; Pavlo Vanat; Dorinda Marques-da-Silva; Joaquim Rui Rodrigues; Ricardo Lagoa. "Metal alginates for polyphenol delivery systems: Studies on crosslinking ions and easy-to-use patches for release of protective flavonoids in skin". Bioactive Materials (2020): https://doi.org/10.1016/j.bioactmat.2020.03.012.
    10.1016/j.bioactmat.2020.03.012
  6. Lagoa, Ricardo; Silva, João; Rodrigues, Joaquim Rui; Bishayee, Anupam. "Advances in phytochemical delivery systems for improved anticancer activity". Biotechnology Advances 38 (2020): 107382. http://dx.doi.org/10.1016/j.biotechadv.2019.04.004.
    10.1016/j.biotechadv.2019.04.004
  7. Joaquim Rui Rodrigues; Jose Carlos Cameselle; Alicia Cabezas; João Ribeiro. "Closure of the Human TKFC Active Site: Comparison of the Apoenzyme and the Complexes Formed with Either Triokinase or FMN Cyclase Substrates". International Journal of Molecular Sciences (2019): https://www.mdpi.com/1422-0067/20/5/1099.
    10.3390/ijms20051099
  8. João Meireles Ribeiro; José Canales; Alicia Cabezas; Joaquim Rui Rodrigues; Rosa María Pinto; Iralis López-Villamizar; María Jesús Costas; et al. "Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-017-18393-9.
    10.1038/s41598-017-18393-9
  9. Cabezas, Alicia; Ribeiro, Joao Meireles; Rodrigues, Joaquim Rui; Lopez-Villamizar, Iralis; Fernandez, Ascension; Canales, Jose; Pinto, Rosa Maria; et al. "Molecular Bases of Catalysis and ADP-Ribose Preference of Human Mn2+-Dependent ADP-Ribose/CDP-Alcohol Diphosphatase and Conversion by Mutagenesis to a Preferential Cyclic ADP-Ribose Phosphohydrolase.". PloS one 10 2 (2015): e0118680-e0118680. http://hdl.handle.net/10400.8/3009.
    10.1371/journal.pone.0118680
  10. Rui Rodrigues, Joaquim; Couto, Ana; Cabezas, Alicia; Maria Pinto, Rosa; Meireles Ribeiro, Joao; Canales, Jose; Jesus Costas, Maria; Carlos Cameselle, Jose. "Bifunctional Homodimeric Triokinase/FMN Cyclase CONTRIBUTION OF PROTEIN DOMAINS TO THE ACTIVITIES OF THE HUMAN ENZYME AND MOLECULAR DYNAMICS SIMULATION OF DOMAIN MOVEMENTS". Journal of Biological Chemistry 289 15 (2014): 10620-10636.
    10.1074/jbc.M113.525626
  11. Rui Rodrigues, Joaquim; Fernandez, Ascension; Canales, Jose; Cabezas, Alicia; Meireles Ribeiro, Joao; Jesus Costas, Maria; Carlos Cameselle, Jose; et al. "Characterization of Danio rerio Mn2+-Dependent ADP-Ribose/CDP-Alcohol Diphosphatase, the Structural Prototype of the ADPRibase-Mn-Like Protein Family". Plos One 7 7 (2012): http://hdl.handle.net/10400.8/3008.
    10.1371/journal.pone.0042249
  12. Rodrigues, J. Rui; Simoes, Carlos J. V.; Silva, Candida G.; Brito, Rui M. M.. "Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: Insights from molecular dynamics simulations". Protein Science 19 2 (2010): 202-219.
    10.1002/pro.289
  13. Canales, José; Fernández, Ascensión; Rodrigues, Joaquim Rui; Ferreira, Rui; Ribeiro, João Meireles; Cabezas, Alicia; Costas, María Jesús; et al. "Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase". Febs Letters 583 10 (2009): 1593-1598. http://hdl.handle.net/10400.8/3028.
    10.1016/j.febslet.2009.04.023
  14. Lagoa, Ricardo; Rodrigues, Joaquim Rui; Lagoa, R.; Rodrigues, J. R.. "Kinetic analysis of metal uptake by dry and gel alginate particles". Biochemical Engineering Journal 46 3 (2009): 320-326. http://hdl.handle.net/10400.8/2342.
    10.1016/j.bej.2009.06.007
  15. Canales, Jose; Fernandez, Ascension; Meireles Ribeiro, Joao; Cabezas, Alicia; Rui Rodrigues, Joaquim; Carlos Cameselle, Jose; Jesus Costas, Maria. "Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells". Biochemical Journal 413 (2008): 103-113.
    10.1042/BJ20071471
  16. Silva, Rui M. P.; Manso, Joao P. H.; Rodrigues, Joaquim R. C.; Lagoa, Ricardo J. L.; Manso, João P. H.; Rodrigues, Joaquim Rui; Lagoa, Ricardo. "A comparative study of alginate beads and an ion-exchange resin for the removal of heavy metals from a metal plating effluent". Journal of Environmental Science and Health Part a-Toxic/hazardous Substances & Environmental Engineering 43 11 (2008): 1311-1317. http://hdl.handle.net/10400.8/2350.
    10.1080/10934520802177953
  17. Lagoa, Ricardo; Rodrigues, J. R.; Rodrigues, Joaquim Rui. "Evaluation of dry protonated calcium alginate beads for biosorption applications and studies of lead uptake". Applied Biochemistry and Biotechnology 143 2 (2007): 115-128. http://hdl.handle.net/10400.8/2351.
    10.1007/s12010-007-0041-4
  18. Vaz, DC; Rodrigues, JR; Sebald, W; Dobson, CM; Brito, RMM; Vaz, Daniela C.; Rodrigues, J. Rui; et al. "Enthalpic and entropic contributions mediate the role of disulfide bonds on the conformational stability of interleukin-4". Protein Science 15 1 (2006): 33-44. http://hdl.handle.net/10400.8/4260.
    10.1110/ps.051593306
  19. Rodrigues, J. Rui; Lagoa, Ricardo; Rodrigues, Joaquim Rui. "Copper ions binding in Cu-alginate gelation". Journal of Carbohydrate Chemistry 25 2-3 (2006): 219-232. http://hdl.handle.net/10400.8/2349.
    10.1080/07328300600732956
  20. Correia, BE; Loureiro-Ferreira, N; Rodrigues, JR; Brito, RMM. "A structural model of an amyloid protofilament of transthyretin". Protein Science 15 1 (2006): 28-32.
    10.1110/ps.051787106
  21. Berrar, D.; Stahl, F.; Silva, C.; Rodrigues, J.R.; Brito, R.M.M.; Dubitzky, W.. "Towards data warehousing and mining of protein unfolding simulation data". Journal of Clinical Monitoring and Computing 19 4-5 (2005): 307-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-30344471278&partnerID=MN8TOARS.
    10.1007/s10877-005-0676-z
  22. Brito, RMM; Dubitzky, W; Rodrigues, JR. "Protein folding and unfolding simulations: A new challenge for data mining". Omics-a Journal of Integrative Biology 8 2 (2004): 153-166.
    10.1089/1536231041388311
Activities

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/03/13 Human Mitochondrial Glutamyl-tRNA Synthetase: Biochemical Studies and Role in Neurological Syndromes
(Thesis) Arguer
 Beatriz Rasgado Lopes (Master)
Universidade de Lisboa, Portugal
2017/07/05 Sistemas de biotransformação e de resposta ao stress de Petromyzon marinus, L
(Thesis) Arguer
 Marta Sofia Garcia Candeias (PhD)
Universidade de Évora, Portugal
2017/04/20 Efeito Crabtree em Saccharomyces cerevisiae e sua modulação por nanopartículas de dióxido de titânio
(Thesis) Arguer
 Joana Manuela Capela Pires (PhD)
Universidade de Évora, Portugal
2015/09/17 CpdB bacteriana y ADPRibasa-Mn humana: estudios de dos hidrolasas activas sobre nucleótidos cíclicos
(Thesis) Arguer
 Iralis Mercedes López Villamizar (PhD)
Universidad de Extremadura, Spain
Distinctions

Other distinction

2015 Prémio Publicação Científica Internacional na área das Ciências da Vida e da Saúde
Instituto Politécnico de Leiria, Portugal
2007 Projeto finalista do Prémio Start - Prémio Nacional de Empreendedorismo