Tiago Folgosa Granja (911C-7562-7CC1)

Curriculum Vitae

Tiago Folgosa Granja

O Tiago Granja graduou-se em Engenharia Biotecnológica na Universidade Lusófona ¿ Lisboa ¿ Portugal e concluiu o mestrado em Biologia Celular e Molecular na Universidade de Coimbra ¿ Coimbra ¿ Portugal de onde se mudou para Bristol ¿ UK para iniciar o seu doutoramento no laboratório MICF ¿ Myocardial Inflammation and Cellular Function no Bristol Royal Infirmary ¿ Bristol ¿ UK. Juntamente com o professor Zackarowski contribuiu para o desenvolvimento de novas funções do recetor de imunidade inata TLR4 e sua sincronização com o eixo hipófise ¿ glândula pituitária ¿ glândulas adrenais e a homeostase cardíaca. Terminou o seu doutoramento em medicina translacional dentro do consorcio da Goethe Universität Frankfurt am Main ¿ Alemanha e Tübingen Universtät Klinikum ¿ Alemanha onde foi responsável pela implementação de novos modelos de microcirurgia animal de inflamação crónica e aguda. Juntamente com o professor Rosenberger em Tübingen concentrou-se na importância da sinapse neuro-imune nos processos inflamatórios em órgãos de choque. Desde então tem-se dedicado ao papel das proteínas neuronais guia na imunidade inata, na função plaquetária, no recrutamento de monócitos, na diferenciação de macrófagos e na sinalização da patofisiologia de ARDS (Acute Respiratory Distress Syndrome) ou IRI (Ischemia/reperfusion Injury). Em 2021 o Tiago Granja integrou o CBIOS (center of Biological Sciences da Universidade Lusófona) onde abraçou a iniciativa de iniciar uma nova carreira na área da imunologia e patofisiologia da microcirculação. Juntamente com o Professor Luís Monteiro Rodrigues explora os limites da Tomografia optoacústica e a sua capacidade em gerar informação 4D de manobras clássicas da fisiologia. Na vanguarda desta tecnologia, no futuro planeia usar a optoacustica como janela de observação da perfusão microvascular, prevenir e diagnosticar alterações cardiovasculares de forma não-invasiva.

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Identification

Personal identification

Full name: Tiago Folgosa Granja

Citation names

Granja, Tiago
Granja, T. F.
Granja, T.

Author identifiers

Ciência ID: 911C-7562-7CC1
ORCID iD: 0000-0002-8137-1449
Researcher Id: D-8426-2014

Email addresses

p6212@ulusofona.pt (Professional)
granja.tiago@gmail.com (Personal)
granja.tiago@outlook.com (Personal)
granja.tiago@yahoo.com (Personal)

Telephones

Mobile phone

932208677 (Personal)
(+49) 1768628 Ext.: 3672 (Personal)

Addresses

Rua Tomás da Anunciação 145, 2Dto, 135-326, Lisboa, Lisboa, Portugal (Personal)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Immunology
Medical and Health Sciences - Basic Medicine - Physiology
Natural sciences - Biological Sciences - Cell Biology
Natural sciences - Biological Sciences - Molecular Biology
Engineering and Technology - Medical Engineering - Medical Laboratory Technology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
German	Advanced (C1)	Advanced (C1)	Upper intermediate (B2)	Proficiency (C2)	Upper intermediate (B2)

Education

	Degree	Classification
2022/02/01 - 2022/07/31 Concluded	Data Science with Python (Curso de Especialização Tecnológica) Major in Programming Universidade Lusófona de Humanidades e Tecnologias, Portugal	N/A
2012/01/18 - 2021/02/15 Concluded	Anaesthesiologie und Intensivmedizin (Postgraduate Certificate) Major in Immunity Universitätsklinikum Tübingen Universitätsklinik für Allgemeine Viszeral- und Transplantationschirurgie, Germany Universitätsklinikum Tübingen Klinik für Anaesthesiologie und Intensivmedizin, Germany
2009/01/05 - 2012/08 Concluded	FIRST Graduate School (Doktor (PhD)) Major in Molecular Medicine Goethe-Universität Frankfurt am Main, Germany Klinikum der Johann Wolfgang Goethe-Universität Frankfurt Klinik für Anästhesiologie Intensivmedizin und Schmerztherapie, Germany "The role of neuronal guidance cue Neogenin during inflammation" (THESIS/DISSERTATION)	Magna Cum Laude
2009/01 Concluded	Molecular Cardioprotection and Inflammation (Postgraduate Certificate) Major in Inflammation Bristol Royal Infirmary Department of Clinical Biochemistry, United Kingdom
2008/11 Concluded	Stress and transcription (Mestrado) Major in Genomics Instituto Gulbenkian de Ciência, Portugal
2003/02 Concluded	Engenharia Biotecnológica (Licenciatura) Major in Biotecnologia Universidade Lusófona de Humanidades e Tecnologias, Portugal

Affiliation

Science

	Category Host institution	Employer
2012/02 - Current	Postdoc (Research)	Eberhard Karls Universität Tübingen, Germany
	Universitätsklinikum Tübingen Klinik für Anaesthesiologie und Intensivmedizin, Germany
2010/01 - 2012/01	Contracted Researcher (Research)	Goethe-Universität Frankfurt am Main, Germany
	Goethe-Universität Frankfurt am Main, Germany
2008/11 - 2010	Contracted Researcher (Research)	Bristol Royal Infirmary, United Kingdom
	Bristol Royal Infirmary, United Kingdom (...)
2007/07 - 2008/11	Auxiliary Researcher (Research)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2006/06 - 2007/05	Research Trainee (Research)	Instituto Gulbenkian de Ciência, Portugal
	Instituto Gulbenkian de Ciência, Portugal
2006/02 - 2006/07	Invited Auxiliary Researcher (Research)	heinische Friedrich-Wilhelms-Universität Bonn Zentrum fur Entwicklungsforschung, Germany
	heinische Friedrich-Wilhelms-Universität Bonn Zentrum fur Entwicklungsforschung, Germany
2005/03 - 2006/02	Research Trainee (Research)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2003/09 - 2005/03	Research Trainee (Research)	Universidade de Lisboa Faculdade de Farmácia, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2021/02/01 - Current	Assistant Professor (University Teacher)	Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
	Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal

Projects

Contract

	Designation	Funders
2021/03/10 - Current	Targeting EphrinA1 chemorepellent properties and its anti-inflammatory potential in granulomatous disease EXPL/MED-IMU/1060/2021 Universidade Lusófona de Humanidades e Tecnologias, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/03 - Current	Targeting EphrinA1 chemorepellent properties and its anti-inflammatory potential in granulomatous disease EXPL/MED-IMU/1060/2021	Fundação para a Ciência e a Tecnologia
2020/07/10 - Current	Phosphorylation of Vasodilator Stimulated Phosphoprotein (VASP) as a switch from axial spondylarthritis (axSpA) tissue damage to retinal inflammation: A systematic analysis of VASP in neurodegeneration and chronic inflammation. DRI/India/0415/2020 Supervisor Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2012/02/01 - 2023/06/06	Neutrophil response during pulmonary sepsis is coordinated by Semaphorin 7A SFB 834 Post-doc Universidade Lusófona de Humanidades e Tecnologias, Portugal Universidade Clínica de Tübingen, Germany	Ongoing

Other

	Designation	Funders
2023/03/31 - Current	Teste do potencial anti-inflamatório do extrato das sementes de Gogi (Lycium barbarum). PLT-Gogi Principal investigator Universidade Lusófona de Humanidades e Tecnologias, Portugal	Under evaluation

Outputs

Publications

Journal article

Sérgio Faloni de Andrade; Tiago Granja; Luis Monteiro Rodrigues. "Comparative view of reactive hyperemia perfusion changes in the upper-limb by laser Doppler flowmetry and optoacoustic tomography and meta-analysis". Journal Biomedical and Biopharmaceutical Research (2023): https://doi.org/10.19277/bbr.20.1.304.
10.19277/bbr.20.1.304
Luis Monteiro Rodrigues; Tiago F. Granja; Sergio Faloni de Andrade. "Optoacoustic Imaging Offers New Insights into In Vivo Human Skin Vascular Physiology". Life (2022): https://doi.org/10.3390/life12101628.
10.3390/life12101628
Tiago F. Granja; David Köhler; Veronika Leiss; Claudia Eggstein; Bernd Nürnberg; Peter Rosenberger; Sandra Beer-Hammer. "Platelets and the Cybernetic Regulation of Ischemic Inflammatory Responses through PNC Formation Regulated by Extracellular Nucleotide Metabolism and Signaling". Cells (2022): https://doi.org/10.3390/cells11193009.
10.3390/cells11193009
Granja T; Faloni de Andrade S; Rodrigues LM. "Multispectral Optoacoustic Tomography for Functional Imaging in Vascular Research.". Journal of visualized experiments : JoVE (2022): http://europepmc.org/abstract/med/35758701.
10.3791/63883
Luis Monteiro Rodrigues; Sérgio Loureiro Nuno; Tiago Granja; Margarida Esteves Florindo; João Gregório; Tiago Atalaia. "Perfusion, Stance and Plantar Pressure Asymmetries on the Human Foot in the Absence of Disease—A Pilot Study". Symmetry (2022): https://doi.org/10.3390/sym14030441.
10.3390/sym14030441
Tiago Granja; Sérgio Faloni de Andrade; Luis Monteiro Rodrigues. "Optoaccoustic Tomography – good news for microcirculatory research". Journal Biomedical and Biopharmaceutical Research 18 2 (2022): 1-1. https://doi.org/10.19277/BBR.18.2.269.
10.19277/BBR.18.2.269
Tiago Granja; Sérgio Faloni de Andrade; Luis Monteiro Rodrigues. "Optoaccoustic Tomography – good news for microcirculatory research". Journal Biomedical and Biopharmaceutical Research (2022): https://doi.org/10.19277/bbr.18.269.
10.19277/bbr.18.269
Granja, Tiago; Hohenstein, Kurt; Schüssel, Patricia; Fischer, Claudius; Prüfer, Thomas; Schibilsky, David; Wendel, Hans Peter; et al. "Multi-Modal Characterization of the Coagulopathy Associated With Extracorporeal Membrane Oxygenation". Critical Care Medicine 48 5 (2020): e400-e408. http://dx.doi.org/10.1097/ccm.0000000000004286.
10.1097/ccm.0000000000004286
Köhler, David; Granja, Tiago; Volz, Julia; Koeppen, Michael; Langer, Harald F.; Hansmann, Georg; Legchenko, Ekaterina; et al. "Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-14958-x.
10.1038/s41467-020-14958-x
Granja, Tiago. "Targeting CD39 Toward Activated Platelets Reduces Systemic Inflammation and Improves Survival in Sepsis: A Preclinical Pilot Study". Critical care medicine (2019): https://doi.org/10.1097/CCM.0000000000003682.
10.1097/ccm.0000000000003682
Granja, Tiago. "Phosphorylation of vasodilator-stimulated phosphoprotein contributes to myocardial ischemic preconditioning". Basic research in cardiology (2018): https://doi.org/10.1007/s00395-018-0667-0.
10.1007/s00395-018-0667-0
Granja, Tiago. "Adenosine Receptor Adora2b Plays a Mechanistic Role in the Protective Effect of the Volatile Anesthetic Sevoflurane during Liver Ischemia/Reperfusion.". Anesthesiology (2016): http://europepmc.org/abstract/med/27404219.
10.1097/aln.0000000000001234
Granja, Tiago. "Inhibition of Plexin C1 Protects Against Hepatic Ischemia-Reperfusion Injury.". Critical care medicine (2016): http://europepmc.org/abstract/med/26963322.
10.1097/ccm.0000000000001609
Granja, Tiago. "The neuroimmune guidance cue netrin-1 controls resolution programs and promotes liver regeneration.". Hepatology (Baltimore, Md.) (2016): http://europepmc.org/abstract/med/26573873.
10.1002/hep.28347
Granja, Tiago. "Inhibition of Adenosine Kinase Attenuates Acute Lung Injury.". Critical care medicine (2016): http://europepmc.org/abstract/med/26491864.
10.1097/ccm.0000000000001370
Granja, Tiago. "Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury.". PloS one (2016): http://europepmc.org/abstract/med/26752048.
10.1371/journal.pone.0146930
Tiago Granja; Jessica Schad; Patricia Schüssel; Claudius Fischer; Helene Häberle; Peter Rosenberger; Andreas Straub. "Using six-colour flow cytometry to analyse the activation and interaction of platelets and leukocytes – A new assay suitable for bench and bedside conditions". Thrombosis Research 136 4 (2015): 786-796. http://dx.doi.org/10.1016/j.thromres.2015.07.009.
10.1016/j.thromres.2015.07.009
Granja, Tiago. "Inhibition of neogenin dampens hepatic ischemia-reperfusion injury.". Critical care medicine (2014): http://europepmc.org/abstract/med/25029243.
10.1097/ccm.0000000000000485
Granja, Tiago. "The plexin C1 receptor promotes acute inflammation.". European journal of immunology (2014): http://europepmc.org/abstract/med/24890788.
10.1002/eji.201343968
Granja, Tiago. "Vagus nerve controls resolution and pro-resolving mediators of inflammation.". The Journal of experimental medicine (2014): http://europepmc.org/abstract/med/24863066.
10.1084/jem.20132103
Granja, Tiago. "Gai2- and Gai3-deficient mice display opposite severity of myocardial ischemia reperfusion injury.". PloS one (2014): http://europepmc.org/abstract/med/24858945.
10.1371/journal.pone.0098325
Granja, T.; Köhler, D.; Mirakaj, V.; Nelson, E.; König, K.; Rosenberger, P.. "Crucial role of Plexin C1 for pulmonary inflammation and survival during lung injury". Mucosal Immunol (2013):
10.1038/mi.2013.104
Köhler, D.; Streißenberger, A.; König, K.; Granja, T.; Roth, J. M.; Lehmann, R.; de Oliveira Franz, C. B.; Rosenberger, P.. "The uncoordinated-5 homolog B (UNC5B) receptor increases myocardial ischemia-reperfusion injury". PLoS One 8 7 (2013): e69477-e69477.
10.1371/journal.pone.0069477
König, K.; Gatidou, D.; Granja, T.; Meier, J.; Rosenberger, P.; Mirakaj, V.. "The axonal guidance receptor neogenin promotes acute inflammation". PLoS One 7 3 (2012): e32145-e32145.
10.1371/journal.pone.0032145
Mirakaj, V.; Jennewein, C.; König, K.; Granja, T.; Rosenberger, P.. "The guidance receptor neogenin promotes pulmonary inflammation during lung injury". FASEB J 26 4 (2012): 1549-58.
10.1096/fj.11-200063
König, K.; Köhler, D.; Granja, T.; Jennewein, C.; Tran, N.; Mirakaj, V.; Kröhnert, F.; Rosenberger, P.. "The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury". PLoS One 7 7 (2012): e41085-e41085.
10.1371/journal.pone.0041085
Granja, Tiago; Mersmann, J.; Koch, A.; Tran, N.; Zimmermann, R.; Granja, T. F.; Larmann, J.; et al. "Toll-like receptor 2 signaling triggers fatal arrhythmias upon myocardial ischemia-reperfusion.". Critical care medicine 38 10 (2010): 1927-32. http://europepmc.org/abstract/med/20855990.
10.1097/ccm.0b013e3181ef455b
Mersmann, J.; Berkels, R.; Zacharowski, P.; Tran, N.; Koch, A.; Iekushi, K.; Dimmeler, S.; et al. "Preconditioning by toll-like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia/reperfusion injury". Crit Care Med 38 3 (2010): 903-9.
10.1097/CCM.0b013e3181ce50e6

Activities

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2021/01/03 - Current	Fisiologia da microcirculação podal Co-supervisor	Fisioterapia (PhD) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2017/04/10 - Current	The chemorepelent effect of neuronal Guidance Protein Semaphorin4D in Acute Lung Injury Co-supervisor	Medicina (PhD) Eberhard Karls Universität Tübingen, Germany

Distinctions

Award

2018	Vortragswettbewerb DIVI Forschungspreis Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin, Germany
2017	Vortragswettbewerb DIVI Forschungspreis Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin, Germany