Sara Alexandra Vinhas Ricardo (9410-648A-A564)

Curriculum Vitae

Sara Alexandra Vinhas Ricardo

Sara Ricardo completed their PhD degree in Molecular Pathology and Genetics in 2011 at Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar. She has a solid background in the pathology field and developed an MSc and Ph.D. degree as a researcher in the Breast Pathology field. After completing the PhD degree, she worked as a post-doc researcher in the Differentiation and Cancer group at i3s (Instituto de Investigação e Inovação da Universidade do Porto). She shifted from breast to ovary cancer research and now leads a research line in ovarian cancer metastization, focused on malignant ascites characterization and patient-derived organoids to perform drug tests. The most impactful research outputs are (1) Creation of ovarian cancer PDO biobank for drug testing; (2) the Identification of the synergistic effect of the combinatory therapies in ovarian cancer cell lines; (3) the Generation of two high-grade serous carcinoma cell lines, with a double-chemoresistant phenotype; (4) the Identification of a Mucin and truncated O-glycan footprint of ovarian cancer cell lines; (5) Definition of glycol-mucin profiles with higher specificity level than CA125 assay. She is now recognized as an expert in molecular pathology of ovarian tumours, participating as an evaluator in national and international project calls (e.g., ERC grants, UK), reviewer of high-impact journals (e.g., Nature Communications, Frontiers in Oncology, Cancers) and Guest Editor in the Cells journal. She has been involved as a supervisor of many graduated/undergraduate students and a jury member of several academic thesis/dissertations. She currently is the supervisor of, 3 BSc students, 3 MSc students and 5 PhD students, 3 of them with projects with fellowships awarded by nationally funded (Ref. 2021.05081.BD; Ref. 2020.04720.BD; Ref. 2022.12584.BD). She is the PI of several research projects (Ref. HOPE, Ref. GI2-CESPU_2022, ImmunoT4OC_GI2- CESPU-2023), and participates as a member in two (Ref. LA/P/0070/2020, upPTXovcar-GI2-CESPU-2022, ). Se submitted several projects to funding agencies as a PI, namely 2 large funding projects as a PI (FCT ref. PTDC/MEC-ONC/2047/2020, PTDC/MEC-ONC/3600/2021, 2022.01567.PTDC and Caixa Research Health 2022 ref. HR22-00170), which had a very good evaluation by the evaluator panel but unfunded. Besides her position as a researcher, Sara Ricardo is an associate professor at IUCS-CESPU, coordinating the Histology (BSc programme), Laboratory Rotations (PhD programme) curricular units, and professor of biomedical investigation (PhD Programme), Histology (Integrated Master programmes). She is also a coordination board member of the Biomedical Sciences BSc programme and the Biomedical Sciences PhD program. She integrates a national commission for assessing and accreditation of higher education programmes at the Agency for Assessment and Accreditation of Higher Education as committee president. She has authored or co-authored 72 publications in international peer-reviewed journals and has an H-index of 21 (Scopus).

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Identification

Personal identification

Full name: Sara Alexandra Vinhas Ricardo

Citation names

Ricardo, Sara

Author identifiers

Ciência ID: 9410-648A-A564
ORCID iD: 0000-0003-4091-2226
Google Scholar ID: https://scholar.google.pt/citations?hl=pt-PT&pli=1&user=2T1Eg6gAAAAJ
Scopus Author Id: 6701567408

Email addresses

sara.ricardo@iucs.cespu.pt (Professional)
sararicardo@hotmail.com (Personal)

Telephones

Telephone

220408800 Ext.: 6115 (Professional)
220408800 Ext.: 6115 (Professional)

Addresses

UCIBIU@IUCS-CESPU - Avenida Central de Gandra, 1317, 4585-116, Gandra PRD, Porto, Portugal (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Pathology

Languages

Language	Speaking	Reading	Writing	Listening
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Spanish; Castilian	Intermediate (B1)	Intermediate (B1)	Elementary (A2)	Intermediate (B1)
French	Intermediate (B1)	Elementary (A2)	Elementary (A2)	Intermediate (B1)

Education

	Degree	Classification
2016/09/15 - 2025/09/15 Ongoing	Bioquímica (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal
2007/12/01 - 2011/09/08 Concluded	Patologia e Genética Molecular (Doutoramento) Major in Medicina Básica Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Identifying cancer stem cells in breast tumours: Searching for cancer origins" (THESIS/DISSERTATION)	Approved with distinction
2005 Concluded	Mestrado em Oncologia Molecular (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal "HER2 evaluation in invasive breast cancer tissue microarrays by immunohistochemistry and chromogen in situ hybridization" (THESIS/DISSERTATION)	Very Good
2002 Concluded	Anatomia Patológica, Citológica e Tanatológica (Licenciatura) Instituto Politécnico do Porto, Portugal "Potential use of loss of heterozygosity in pleural effusions of breast cancer metastases using the microsatellite marker of the 16q22.1 region of the CDH1 gene" (THESIS/DISSERTATION)	14

Affiliation

Science

	Category Host institution	Employer
2019/02/01 - Current	Researcher (Research)	Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
	Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2019/02/01 - Current	Researcher (Research)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/01/01 - 2019/12/15	Contracted Researcher (Research)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2014/09/01 - 2016/12/31	Postdoc (Research)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012/10/01 - 2014/08/31	Contracted Researcher (Research)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2002/02/01 - 2012/10/31	Researcher (Research)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2019/02/01 - Current	Assistant Professor (University Teacher)	Instituto Universitário de Ciências da Saúde, Portugal
	Instituto Universitário de Ciências da Saúde, Portugal
2019/09/01 - 2020/09/15	Invited Adjunct Teacher (Polytechnic Teacher)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

2015/09/10 - 2016/02/29	Invited Assistant (Polytechnic Teacher)	Instituto Politécnico de Bragança Escola Superior de Saúde de Bragança, Portugal

2005/09/01 - 2013/02/28	Invited Adjunct Teacher (Polytechnic Teacher)	Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Others

	Category Host institution	Employer
2015/05/04 - 2023/01/01	Affiliate Professor	Universidade do Porto Faculdade de Medicina, Portugal

2002/02/01 - 2012/08/27	Pathology technician (Pathology Department)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Projects

Grant

	Designation	Funders
2015/07/01 - 2017/04/30	Exploring glyco-mucin profiles for Ovarian Cancer detection SFRH/BPD/100358/2014 Post-doc Fellow Fundação para a Ciência e a Tecnologia, Portugal

Contract

	Designation	Funders
2023/12/12 - Current	Exploring the effectiveness of pitavastatin to potentiate immunotherapy using ovarian cancer ascites immune-organoid cultures. (ImmunoT4OC) 129-GI2-CESPU-2023 Principal investigator Cooperativa de Ensino Superior Politécnico e Universitário, Portugal	Ongoing
2022/09/01 - Current	Ovarian Cancer Ascites-Derived Organoids as a Preclinical Platform to Predict Therapeutical Responses GI2-CESPU_2022 Principal investigator Cooperativa de Ensino Superior Politécnico e Universitário, Portugal	Ongoing
2022/09/01 - Current	Overcoming paclitaxel resistance in ovarian cancer upPTXovcar-GI2-CESPU-2022 Researcher Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal	Ongoing
2021/11/25 - Current	EXPLORING THE MULTIDIMENTIONAL POTENTIAL OF OVARIAN CANCER ASCITES TO IMPROVE PATIENT’S SURVIVAL HR22-00170 Principal investigator la Caixa Foundation, Spain	la Caixa Foundation Not funded
2018/04/01 - Current	HOPE - Improving ovarian cancer patients survival HOPE Principal investigator Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Ongoing
2021/01/01 - 2025/12/31	Instituto para a Saúde e a Bioeconomia LA/P/0140/2020 10.54499/LA/P/0140/2020 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Universidade Nova de Lisboa, Portugal INESC Microsistemas e Nanotecnologias, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/01/01 - 2025/12/31	Institute for Research and Innovation in Health LA/P/0070/2020 Instituto Nacional de Engenharia Biomédica, Portugal Universidade do Porto, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/01/01 - 2023/12/31	Unidade de Ciências Biomoleculares Aplicadas UIDB/04378/2020 10.54499/UIDB/04378/2020 Universidade Nova de Lisboa, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2020/01/01 - 2023/12/31	Unidade de Ciências Biomoleculares Aplicadas UIDP/04378/2020 10.54499/UIDP/04378/2020 Universidade Nova de Lisboa, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2023/05/01 - 2023/06/30	OVCARTREAT - Drug repurpusing as a strategy to treat ovarian cancer PrémioAlfredodaSilva Principal investigator Universidade NOVA de Lisboa, Portugal	Universidade NOVA de Lisboa Not funded
2023/03/01 - 2023/06/30	Unveiling the Molecular Kinetics in Ovarian Cancer Ascites to Improve Patient FAZCIÊNCIA2023 Principal investigator Fundação AstraZeneca, Portugal	Fundação AstraZeneca Not funded
2022/12/30 - 2023/06/30	TUMOR CELLS PRESENT IN DISCARDED OVARIAN CANCER ASCITES ARE CRUCIAL TO MONITOR THERAPY RESISTANCE PRÉMIOHOLOGIC2023 Principal investigator HOLOGIC, United States	Not funded
2022/02/01 - 2022/12/16	Tratamento do cancro do endométrio com a combinação de imunoterapia e modeladores epigenéticos: nova abordagem com modelos in vitro de co-culturas 2022.08490.PTDC Researcher	Not funded
2022/02/01 - 2022/12/15	Creation of a drug test using ovarian cancer ascites-derived organoids 2022.01567.PTDC Principal investigator	Not funded
2022/02/01 - 2022/12/15	Descobrir novas vulnerabilidades das células de cancro através do código m6A do RNA 2022.03843.PTDC Researcher	Not funded
2022/02/01 - 2022/12/15	Identificação de inibidores específicos da função da proteína HMGA1 com impacto no comportamento do cancro gástrico 2022.01764.PTDC Researcher Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Not funded
2018/07/15 - 2022/01/15	Blocking MUC16-mesothelin interaction to abrogate peritoneal metastization of ovarian cancer (PTDC/MEC-ONC/29503/2017) PTDC/MEC-ONC/29503/2017 PTDC/MEC-ONC/29503/2017 Researcher Fundação para a Ciência e a Tecnologia, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	N/A Concluded
2018/07/01 - 2021/12/31	Reconstructing the Program of Cancer Stem Cells PTDC/MED-ONC/29017/2017 Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2021/02/28 - 2021/06/30	Construção de um reservatório de células vivas de líquido ascítico de pacientes com cancro do ovário para testar ex vivo a resposta ao tratamento PTDC/MEC-ONC/3600/2021 Principal investigator Fundação para a Ciência e a Tecnologia, Portugal	Not funded
2020/06/01 - 2021/03/01	RESEARCH COVID-19 ao projeto 510 - Impact of covid-19 on the treatment of cancer patients [ 613686665 ] [ 613686665 ] Researcher Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/02/29 - 2020/11/20	Construction of a living reservoir from ovarian cancer patient’s ascitic fluid to test treatment response PTDC/MEC-ONC/2047/2020 Principal investigator Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia Not funded
2019/01/01 - 2019/12/31	Instituto de Investigação e Inovação em Saúde UID/BIM/04293/2019 Instituto Nacional de Engenharia Biomédica, Portugal Universidade do Porto, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2017/05 - 2019/05	Advancing cancer research: from basic knowledgment to application II (CANCER) NORTE-01-0145-FEDER-000029	Horizon 2020 Framework Programme
2016/05/01 - 2019/04/30	Advancing cancer research: from basic knowledge to application NORTE–01–0145–FEDER–000029 Researcher Horizon 2020 European Innovation Council Fast Track to Innovation, Belgium	Ongoing
2016/05/01 - 2019/04/30	Diabetes & obesity at the crossroads between Oncological and Cardiovascular diseases - a system analysis NETwork towards precision medicin NORTE-01-0145-FEDRER-000003 Researcher Horizon 2020 European Innovation Council Fast Track to Innovation, Belgium	Ongoing
2012/10/01 - 2015/10/01	Mucin MUC16 - CA125 cancer biomarker - biological functions and development of new biomarker assays BIO MUC16 Researcher Fundação para a Ciência e a Tecnologia, Portugal
2013/01/01 - 2015/06/30	Differentiation in cancer with emphasis on glycoproteome alterations ON	Concluded
2011/06/01 - 2012/12/31	Vírus do papiloma Humano (HPV) como agente etiológico de cancro oral 05-GCD-CICS-11 Researcher Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2009/06/01 - 2011/12/31	Estudo da expressão de proteínas reguladoras do ciclo celular na carcinogénese oral 01-GCDCICS-09 Researcher Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2009/06/01 - 2011/12/31	Tumores Odontógénicos queratoquísticos – uma verdadeira neoplasia? 02-GCD-CICS-09 Researcher
2009/01/01 - 2011/07/31	Basal-like Breast Cancer: are mammary stem cells new targets for cancer therapy? FCG 96633 - 3009 Researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2007/10/01 - 2011/04/01	Prevention and Early Diagnosis of Cancer and Precancerous Lesions of Cervix, Stomach, Breast and Thyroid PT0009 Researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Concluded

Outputs

Publications

Book	Ricardo, Sara. Identifying Cancer Stem Cells in breast tumours: Searching for Cancer Origins. Porto, Portugal: Edição de Autor. 2011. Published
Book chapter	Nunes, Mariana; Nunes, Diana; Ricardo, Sara. "Cell Microarray: An Approach to Evaluate Drug-Induced Alterations in Protein Expression". In Advancements in Cancer Research, 133-144. Exon Publications, 2023. 10.36255/cell-microarray Almeida-Nunes, DL; Ricardo, Sara. "Ovarian Cancer Ascites as a Liquid Tumor Microenvironment". In Ovarian Cancer, 43-55. Australia: Exon Publications, 2022. Published • 10.36255/exon-publications-ovarian-cancer-tumor-microenvironment Nunes, Mariana; Ricardo, Sara. "Chemoresistance in Ovarian Cancer: The Role of Malignant Ascites". In Ovarian Cancer, 27-42. Exon Publications, 2022. Published • 10.36255/exon-publications-ovarian-cancer-malignant-ascites
Conference abstract	Coelho, R; Ricardo, S; Amaral, AL; Theodorakis, I; Jacob, F; David, L. "Po-247 mesothelin regulates invasion and peritoneal metastization of ovarian cancer". 2018. 10.1136/esmoopen-2018-eacr25.763 Ricardo, S.; Silva, L.; Pereira, D.; Lunet, N.; David, L.. "696: Glycoprofiling of serous ovarian tumours is a promising strategy for developing new diagnostic tools". Paper presented in EACR, 2014. 10.1016/s0959-8049(14)50614-4 Ricardo, Sara. "PLA identifies glycopeptides (T/ST) carried by MUC16 and MUC1 as putative biomarkers discriminating different subgroups of serous ovarian tumours". 2013. Published Ricardo S; Gerhard R; Cameselle-Teijeiro JF; Schmitt F; Paredes J. "Claudin expression in breast cancer: high or low, what to expect?". 2012. Albergaría, A.; Nobre, A.; Vieira, A.; Ricardo, S.A.R.A.; Sousa, B.; Seruca, R.; Paredes, J.; Schmitt, F.. "488 TAp63 Counteracts Invasive and Stem Cell Properties Mediated by P-cadherin in Breast Cancer Cells". 2012. 10.1016/s0959-8049(12)71159-0 Ribeiro, A.S.; Carreto, L.C.; Albergaria, A.; Sousa, B.; Ricardo, S.; Milanezi, F.; Seruca, R.; et al. "514 Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter?". 2010. 10.1016/s1359-6349(10)71315-x Ricardo, Sara. "CANCER STEM CELLS CHARACTERIZATION IN INVASIVE BREAST CARCINOMAS THROUGH CD44, CD24 AND ALDH1 EXPRESSION". 2010.
Conference paper	Ribeiro, Ana S.; Carreto, Laura C.; Albergaria, André; Sousa, Bárbara; Ricardo, Sara; Milanezi, Fernanda; Seruca, Raquel; et al. "Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter?". 2010. 10.1186/1753-6561-4-S2-P47
Conference poster	Nunes, Mariana; Ricardo, Sara. "Repurposing Ivermectin to Enhance Chemotherapy’s Effectiveness in High-Grade Serous Carcinoma". Paper presented in EACR 2024 Congress: Innovative Cancer Science, 2024. Almeida-Nunes, DL; Mendes-Frias, Ana ; Nunes, Mariana; Ferreira, Verónica; Lobo, Cláudia; Monteiro, Paula; Abreu, Miguel Henriques; et al. "Presence of exhausted lymphocytes in the ascitic microenvironment of ovarian cancer patients: implications for immune dysfunction". Paper presented in VII iBiMED Symposium, Universidade de Aveiro, 2024. Nunes, Mariana; Costa, João; Bartosch, Carla; Ricardo, Sara. "The Expression of mRNA LGR6 is Increased in Low-Grade Serous Carcinoma". Paper presented in XXX Porto Cancer Meeting: RNA Biology in Cancer, 2024. Nunes, Mariana; Almeida-Nunes, DL; Costa, Anabela; Ricardo, Sara. "Cell microarray as a powerful tool to accelerate cancer research: focus on drug screening". Paper presented in II TOXRUN International Congress 2023. (2023). No Boundaries for Toxicology: One Health, One Society, One Planet. Scientific Letters, 1(Sup 1)., 2023. Almeida-Nunes, Diana Luísa; Mendes-Frias, Ana ; Dinis-Oliveira, Ricardo Jorge; Silvestre, Ricardo; Ricardo, Sara. "The influence of tumor microenvironment immunein ovarian cancer ascites". Paper presented in The Structural Microenvironment: Breaking down the walls of cancer, 2023. Almeida-Nunes, DL; Nunes, Mariana; Osorio, Hugo; Ferreira, Verónica; Lobo, Claudia; Monteiro, Paula; Henriques Abreu, Miguel; et al. "Análise proteómica de ascites de pacientes com cancro do ovário reflete a modificação metabólica no microambiente tumoral durante a quimioterapia". Paper presented in 8º Curso Avançado de Ginecologia Oncológica, realized in Instituto Português de Oncologia do Porto, Francisco Gentil, EPE, Porto, Portugal, 2023. Nunes, Mariana; Duarte, Diana; Vale, Nuno; Ricardo, Sara. "Synergism between carboplatin and repurposed drugs in chemoresistant high-grade serous carcinoma". Paper presented in EACR: The invisible phase of metastasis: Impact of dormancy, cancer cell plasticity and evolution of the niche during metastatic progression - Virtual Event, 2022. Nunes, Mariana; Almeida-Nunes, Diana; Abreu, Miguel; Bartosch, Carla; Ricardo, Sara. "Recycling the discarded ovarian cancer ascites to monitor therapy resistance". Paper presented in 23rd European Congress on Gynaecological Oncology, 2022. Nunes, Mariana; Duarte, Diana; Vale, Nuno; Ricardo, Sara. "Combining Repurposing Drugs with Paclitaxel Has a Synergic Effect in Chemoresistant High-Grade Serous Carcinoma". Paper presented in 5th ASPIC International Congress, 2022. Brandão, Catarina; Nunes, Diana; Nunes, Mariana; Osório, Hugo; Ricardo, Sara. "Development of an In Silico Approach to Identify Key Proteins Involved in the Peritoneal Dissemination of Ovarian Cancer". Paper presented in VII Jornadas da Bioquímica, 2022. Nunes, Mariana; Brandão, Catarina; Ricardo, Sara. "Combining Paclitaxel with Repurposing Drugs Improve Ovarian Cancer Management". Paper presented in I Congresso Internacional da TOXRUN/ V Congresso da Associação Portuguesa de Ciências Forenses/XIV Jornadas Científicas de Ciências do Instituto Universitário de Ciências da Saúde, 2022. Ferreira, Sílvia; Nunes, Mariana; Nunes, Diana; Ricardo, Sara. "Phenotypic Evaluation of the Ovarian Tumor Cells Presents in Malignant Ascites". Paper presented in I Congresso Internacional da TOXRUN/ V Congresso da Associação Portuguesa de Ciências Forenses/XIV Jornadas Científicas de Ciências do Instituto Universitário de Ciências da Saúde, 2022. Almeida-Nunes, Diana Lua; Mendes-Frias, Ana ; Dinis-Oliveira, Ricardo Jge; Silvestre, Ricardo; Ricardo, Sara. "Immune tumor microenvironment of ovarian cancer ascites". 2022. Nunes, Mariana; Ricardo, Sara. "Pitavastatin Partially Restore Paclitaxel Sensitivity in High-Grade Serous Carcinoma Cell Lines". Paper presented in EACR Conference 2021: Goodbye Flat Biology: Next Generation Cancer Models, virtual event, worldwide., 2021. Coelho, Ricardo; Ricardo, Sara; Amaral, Ana Luísa; Huang, Yen-Lin; Nunes, Mariana; Jacob, Francis; David, Leonor. "Mesothelin-expressing ovarian cancer cells exhibit enhanced invasion and peritoneal dissemination". Paper presented in EACR-AACR-ASPIC Conference 2020: Tumor Microenvironment, 2020. Nunes, Mariana; Coelho, Ricardo; David, Leonor; Ricardo, Sara. "A mesotelina modula a quimioresistência à carboplatina em linhas celulares do cancro do ovário". Paper presented in 1º Encontro Nacional de Jovens Investigadores em Oncologia, 2019. Nunes, Mariana; Coelho, Ricardo; Portugal, Raquel; Costa, Antonia; Lopes, José Manuel; David, Leonor; Ricardo, Sara. "Reduced expression of MUC16 and MSLN in cells from ascitic fluid and ovarian cancer cell lines". Paper presented in 7th i3S Annual Meeting, 2018. Coelho, Ricardo; Ricardo, Sara; Amaral, Ana Luísa; Huang, Yen-Lin; Heinzelmann-Schwarz, Viola; David, Leonor; Jacob, Francis. "Generation of CRISPR Cas9-mediated MSLN knockout ovarian cancer cell lines". Paper presented in 3 rd ASPIC International Congress,, 2018. Coelho, Ricardo; Ricardo, Sara; Marcos-Silva, Lara; David, Leonor. "Three dimensional culture model mimicking peritoneal seeding of human ovarian cancer". Paper presented in 2nd Goodbye Flat Biology Models, 2016. Delgado, Leonor; Teixeira, J; Garcez, Fernanda; Ricardo, Sara; Ferreira, F; Lopes, C; Monteiro, Luís. "PTEN and p-mTORSER2448 expression in oral squamous cell carcinomas". Paper presented in XXI Porto cancer Meeting (IPATIMUP, Porto), 2012. Teixeira, J; Delgado, Leonor; Garcez, Fernanda; Ricardo, Sara; Ferreira, F; Lopes, C. "pEGFRTyr1173 overexpression correlates with overall survival in oral squamous cell carcinomas". Paper presented in XXI Porto cancer Meeting (IPATIMUP, Porto), 2012. Garcez, Fernanda; Monteiro, Luís; Ricardo, Sara; Ferreira, F; Barbas do Amaral, José. "P63 como marcador stem-cell em tumores odontogénicos queratoquísticos. Um estudo imunohistoquimico". Paper presented in XIX Jornadas de Ciências de Medicina Dentária do Instituto Superior de Ciências da Saúde do Norte (Alfândega do Porto, Portugal), 2011.
Edited book	Ricardo, Sara. I Congresso Nacional de Ciências Biomédicas Laboratoriais: livro de resumos. Bragança, Portugal: Instituto Politécnico de Bragança. 2016. Published • Editor
Journal article	Almeida-Nunes, Diana Luísa; Silva, João P. N.; Nunes, Mariana; Silva, Patrícia M. A.; Silvestre, Ricardo; Dinis-Oliveira, Ricardo Jorge; Bousbaa, Hassan; Ricardo, Sara. "Metformin Impairs Linsitinib Anti-Tumor Effect on Ovarian Cancer Cell Lines". International Journal of Molecular Sciences 25 22 (2024): 11935. http://dx.doi.org/10.3390/ijms252211935. Published • 10.3390/ijms252211935 Nunes, Mariana; Almeida-Nunes, Diana Luísa; Ferreira, Verónica; Lobo, Cláudia; Monteiro, Paula; Abreu, Miguel Henriques; Bartosch, Carla; Ricardo, Sara. "Que outra utilidade clínica poderão ter as ascites no carcinoma do ovário?". Revista Portuguesa de Oncologia 7 1-2 (2024): Almeida-Nunes, Diana Luísa; Nunes, Mariana; Osório, Hugo; Ferreira, Verónica; Lobo, Cláudia; Monteiro, Paula; Abreu, Miguel Henriques; et al. "Ovarian cancer ascites proteomic profile reflects metabolic changes during disease progression". Biochemistry and Biophysics Reports 39 (2024): 101755. http://dx.doi.org/10.1016/j.bbrep.2024.101755. Published • 10.1016/j.bbrep.2024.101755 Nunes, Mariana; Bartosch, Carla; Abreu, Miguel Henriques; Richardson, Alan; Almeida, Raquel; Ricardo, Sara. "Deciphering the Molecular Mechanisms behind Drug Resistance in Ovarian Cancer to Unlock Efficient Treatment Options". Cells (2024): https://doi.org/10.3390/cells13090786. 10.3390/cells13090786 Fonseca, Jéssica; Vaz, Josiana A.; Ricardo, Sara. "The Potential of Mushroom Extracts to Improve Chemotherapy Efficacy in Cancer Cells: A Systematic Review". Cells 13 6 (2024): 510. http://dx.doi.org/10.3390/cells13060510. 10.3390/cells13060510 Almeida-Nunes, Diana Luísa; Silvestre, Ricardo; Dinis-Oliveira, Ricardo Jorge; Ricardo, Sara. "Enhancing Immunotherapy in Ovarian Cancer: The Emerging Role of Metformin and Statins". International Journal of Molecular Sciences 25 1 (2023): 323. http://dx.doi.org/10.3390/ijms25010323. 10.3390/ijms25010323 Doroteya Raykova; Despoina Kermpatsou; Tony Malmqvist; Philip J. Harrison; Marie Rubin Sander; Christiane Stiller; Johan Heldin; et al. "Author Correction: A method for Boolean analysis of protein interactions at a molecular level". Nature Communications (2023): https://doi.org/10.1038/s41467-023-41325-3. 10.1038/s41467-023-41325-3 Abreu, Miguel Henriques; Lillsunde-Larsson, Gabriella; Bartosch, Carla; Ricardo, Sara. "Editorial: New molecular approaches to improve gynecological cancer management". Frontiers in Oncology 13 (2023): http://dx.doi.org/10.3389/fonc.2023.1235035. 10.3389/fonc.2023.1235035 Batista-Pinto, Carla; Resende, A.D.; Andrade, R.; Garcez, Fernanda; Ricardo, Sara. Corresponding author: Batista-Pinto, Carla. "Tumor aggregates from ovarian cancer patients ascitic fluid present low caspase-3 expression". Scientific Letters 1 Sup 1 (2023): 69. Published Nunes, Mariana; Duarte, Diana; Vale, Nuno; Ricardo, Sara. "The antineoplastic effect of carboplatin is potentiated by combination with pitavastatin or metformin in a chemoresistant high-grade serous carcinoma cell line". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms24010097. 10.3390/ijms24010097 Diana Duarte; Mariana Nunes; Sara Ricardo; Nuno Vale. "Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action". Biomolecules (2022): https://doi.org/10.3390/biom12101490. 10.3390/biom12101490 Diana Luísa Almeida-Nunes; Ana Mendes-Frias; Ricardo Silvestre; Ricardo Jorge Dinis-Oliveira; Sara Ricardo. "Immune Tumor Microenvironment in Ovarian Cancer Ascites". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231810692. 10.3390/ijms231810692 Mariana Nunes; Diana Duarte; Nuno Vale; Sara Ricardo. "Pitavastatin and Ivermectin Enhance the Efficacy of Paclitaxel in Chemoresistant High-Grade Serous Carcinoma". Cancers (2022): https://doi.org/10.3390/cancers14184357. 10.3390/cancers14184357 Doroteya Raykova; Despoina Kermpatsou; Tony Malmqvist; Philip J. Harrison; Marie Rubin Sander; Christiane Stiller; Johan Heldin; et al. "A method for Boolean analysis of protein interactions at a molecular level". Nature Communications (2022): https://doi.org/10.1038/s41467-022-32395-w. 10.1038/s41467-022-32395-w Sara Ricardo; Pedro Canão; Diana Martins; Ana C. Magalhães; Marina Pereira; Ulysses Ribeiro-Junior; Evandro Sobroza de Mello; et al. "Searching for SARS-CoV-2 in Cancer Tissues: Results of an Extensive Methodologic Approach based on ACE2 and Furin Expression". Cancers (2022): https://doi.org/10.3390/cancers14112582. 10.3390/cancers14112582 Magalhães, Ana C.; Ricardo, Sara; Moreira, Ana C.; Nunes, Mariana; Tavares, Margarida; Pinto, Ricardo J.; Gomes, Maria Salomé; Pereira, Luisa. "InfectionCMA: A Cell MicroArray Approach for Efficient Biomarker Screening in In Vitro Infection Assays". Pathogens 11 3 (2022): 313. http://dx.doi.org/10.3390/pathogens11030313. 10.3390/pathogens11030313 Mariana Nunes; Francisca Pacheco; Ricardo Coelho; Dina Leitão; Sara Ricardo; Leonor David. "Mesothelin Expression Is Not Associated with the Presence of Cancer Stem Cell Markers SOX2 and ALDH1 in Ovarian Cancer". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23031016. 10.3390/ijms23031016 "Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines With Increased Expression of P-Glycoprotein". Frontiers in Oncology 11 (2021): http://dx.doi.org/10.3389/fonc.2021.752127. 10.3389/fonc.2021.752127 Nunes, Mariana; Henriques Abreu, Miguel; Bartosch, Carla; Ricardo, Sara. "Recycling the Purpose of Old Drugs to Treat Ovarian Cancer". International Journal of Molecular Sciences 21 20 (2020): 7768. http://dx.doi.org/10.3390/ijms21207768. Open access • 10.3390/ijms21207768 Coelho, Ricardo; Ricardo, Sara; Amaral, Ana Luísa; Huang, Yen-Lin; Nunes, Mariana; Neves, José Pedro; Mendes, Nuno; et al. "Regulation of invasion and peritoneal dissemination of ovarian cancer by mesothelin manipulation". Oncogenesis 9 6 (2020): http://dx.doi.org/10.1038/s41389-020-00246-2. 10.1038/s41389-020-00246-2 Coelho, Ricardo; Marcos-Silva, Lara; Mendes, Nuno; Pereira, Daniela; Brito, Catarina; Jacob, Francis; Steentoft, Catharina; et al. "Mucins and Truncated O-Glycans Unveil Phenotypic Discrepancies between Serous Ovarian Cancer Cell Lines and Primary Tumours". International Journal of Molecular Sciences 19 7 (2018): 2045. http://dx.doi.org/10.3390/ijms19072045. Published • 10.3390/ijms19072045 Coelho, Ricardo; Marcos-Silva, Lara; Ricardo, Sara; Ponte, Filipa; Costa, Antonia; Lopes, Jose Manuel; David, Leonor. "Peritoneal dissemination of ovarian cancer: role of MUC16-mesothelin interaction and implications for treatment". Expert Review of Anticancer Therapy 18 2 (2017): 177-186. http://dx.doi.org/10.1080/14737140.2018.1418326. Published • 10.1080/14737140.2018.1418326 Sadio, Ana; Amaral, Ana L.; Nunes, Rute; Ricardo, Sara; Sarmento, Bruno; Almeida, Raquel; Tsukamoto, Hidekazu; et al. "A Mouse Intra-Intestinal Infusion Model and its Application to the Study of Nanoparticle Distribution". Frontiers in Physiology 7 (2016): http://dx.doi.org/10.3389/fphys.2016.00579. 10.3389/fphys.2016.00579 Sousa, Andreia Mota; Rei, Margarida; Freitas, Rita; Ricardo, Sara; Caffrey, Thomas; David, Leonor; Almeida, Raquel; et al. "Effect of MUC1/ß-catenin interaction on the tumorigenic capacity of pancreatic CD133+ cells". Oncology Letters 12 3 (2016): 1811-1817. http://dx.doi.org/10.3892/ol.2016.4888. 10.3892/ol.2016.4888 Ricardo, Sara; Marcos-Silva, Lara; David, Leonor. "Mucin carriers of TF in ovarian cancer". Journal of Cancer Research and Clinical Oncology 142 8 (2016): 1867-1868. http://dx.doi.org/10.1007/s00432-016-2186-4. 10.1007/s00432-016-2186-4 Ricardo, Sara; Marcos-Silva, Lara; Valente, Cristina; Coelho, Ricardo; Gomes, Rosa; David, Leonor. "Mucins MUC16 and MUC1 are major carriers of SLea and SLex in borderline and malignant serous ovarian tumors". Virchows Archiv 468 6 (2016): 715-722. http://dx.doi.org/10.1007/s00428-016-1929-6. 10.1007/s00428-016-1929-6 Monteiro, LS; Delgado, ML; Ricardo, S; do Amaral, B; Salazar, F; Pacheco, JJ; Lopes, CA; Bousbaa, H; Warnakulasuryia, S. "Prognostic significance of CD44v6, p63, podoplanin and MMP-9 in oral squamous cell carcinomas". Oral Diseases 22 4 (2016): 303-312. http://dx.doi.org/10.1111/odi.12442. 10.1111/odi.12442 Marcos-Silva, Lara; Ricardo, Sara; Chen, Kowa; Blixt, Ola; Arigi, Emma; Pereira, Daniela; Høgdall, Estrid; et al. "A novel monoclonal antibody to a defined peptide epitope in MUC16". Glycobiology 25 11 (2015): 1172-1182. http://dx.doi.org/10.1093/glycob/cwv056. 10.1093/glycob/cwv056 Cohen-Dvashi, Hadas; Ben-Chetrit, Nir; Russell, Roslin; Carvalho, Silvia; Lauriola, Mattia; Nisani, Sophia; Mancini, Maicol; et al. "Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression". EMBO Molecular Medicine 7 3 (2015): 299-314. http://dx.doi.org/10.15252/emmm.201404134. 10.15252/emmm.201404134 Camilo, Vânia; Garrido, Mónica; Valente, Pedro; Ricardo, Sara; Amaral, Ana Luísa; Barros, Rita; Chaves, Paula; et al. "Differentiation reprogramming in gastric intestinal metaplasia and dysplasia: role of SOX2 and CDX2". Histopathology 66 3 (2014): 343-350. http://dx.doi.org/10.1111/his.12544. 10.1111/his.12544 Ricardo, Sara; Marcos-Silva, Lara; Pereira, Daniela; Pinto, Rita; Almeida, Raquel; Söderberg, Ola; Mandel, Ulla; et al. "Detection of glyco-mucin profiles improves specificity of MUC16 and MUC1 biomarkers in ovarian serous tumours". Molecular Oncology 9 2 (2014): 503-512. http://dx.doi.org/10.1016/j.molonc.2014.10.005. 10.1016/j.molonc.2014.10.005 Monteiro, Luís Silva; Delgado, Maria Leonor; Ricardo, Sara; Garcez, Fernanda; Amaral, Barbas do; Pacheco, José Júlio; Lopes, Carlos; Bousbaa, Hassan. "EMMPRIN Expression in Oral Squamous Cell Carcinomas: Correlation with Tumor Proliferation and Patient Survival". BioMed Research International 2014 (2014): 1-9. http://dx.doi.org/10.1155/2014/905680. 10.1155/2014/905680 Monteiro, Luís Silva; Delgado, Maria Leonor; Ricardo, Sara; Garcez, Fernanda; Amaral, Barbas do; Warnakulasuriya, Saman; Lopes, Carlos. "Phosphorylated mammalian target of rapamycin is associated with an adverse outcome in oral squamous cell carcinoma". Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 115 5 (2013): 638-645. http://dx.doi.org/10.1016/j.oooo.2013.01.022. 10.1016/j.oooo.2013.01.022 Monteiro, LS; Ricardo, S; Delgado, ML; Garcez, F; do Amaral, B; Lopes, C. "Phosphorylated EGFR at tyrosine 1173 correlates with poor prognosis in oral squamous cell carcinomas". Oral Diseases 20 2 (2013): 178-185. http://dx.doi.org/10.1111/odi.12087. 10.1111/odi.12087 Ribeiro, Ana Sofia; Sousa, Bárbara; Carreto, Laura; Mendes, Nuno; Nobre, Ana Rita; Ricardo, Sara; Albergaria, André; et al. "P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model". The Journal of Pathology 229 5 (2013): 705-718. http://dx.doi.org/10.1002/path.4143. 10.1002/path.4143 Ricardo, Sara; Gerhard, Renê; Ricardo, Sara; Albergaria, André; Gomes, Madalena; Silva, Alfredo Ribeiro; Logullo, Ângela Flavia; et al. "Immunohistochemical features of claudin-low intrinsic subtype in metaplastic breast carcinomas". The Breast 21 3 (2012): 354-360. http://dx.doi.org/10.1016/j.breast.2012.03.001. 10.1016/j.breast.2012.03.001 Schmitt, Fernando; Ricardo, Sara; Vieira, André Filipe; Dionísio, Maria Rita; Paredes, Joana. "Cancer stem cell markers in breast neoplasias: their relevance and distribution in distinct molecular subtypes". Virchows Archiv 460 6 (2012): 545-553. http://dx.doi.org/10.1007/s00428-012-1237-8. 10.1007/s00428-012-1237-8 Vieira, André Filipe; Ricardo, Sara; Ablett, Matthew Paul; Dionísio, Maria Rita; Mendes, Nuno; Albergaria, André; Farnie, Gillian; et al. "P-Cadherin Is Coexpressed with CD44 and CD49f and Mediates Stem Cell Properties in Basal-like Breast Cancer". STEM CELLS 30 5 (2012): 854-864. http://dx.doi.org/10.1002/stem.1075. 10.1002/stem.1075 Albergaria, André; Ricardo, Sara; Milanezi, Fernanda; Carneiro, Vítor; Amendoeira, Isabel; Vieira, Daniella; Cameselle-Teijeiro, Jorge; Schmitt, Fernando. "Nottingham Prognostic Index in Triple-Negative Breast Cancer: a reliable prognostic tool?". BMC Cancer 11 1 (2011): http://dx.doi.org/10.1186/1471-2407-11-299. 10.1186/1471-2407-11-299 Ricardo, S.; Vieira, A. F.; Gerhard, R.; Leitao, D.; Pinto, R.; Cameselle-Teijeiro, J. F.; Milanezi, F.; Schmitt, F.; Paredes, J.. "Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype". Journal of Clinical Pathology 64 11 (2011): 937-946. http://dx.doi.org/10.1136/jcp.2011.090456. 10.1136/jcp.2011.090456 Ricardo, Sara. "Expression of claudins in breast cancer: high or low, what to expect?". Virchows Archiv 459Suppl1 S71 (2011): Ricardo, Sara. "Immunohistochemical expression of claudins in metaplastic breast cancer.". Virchows Archiv 549 Sup1 S71 (2011): Published Pinheiro, Céline; Reis, Rui M.; Ricardo, Sara; Longatto-Filho, Adhemar; Schmitt, Fernando; Baltazar, Fátima. "Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44". Journal of Biomedicine and Biotechnology 2010 (2010): 1-7. http://dx.doi.org/10.1155/2010/427694. 10.1155/2010/427694 Milanezi, Fernanda; Leitão, Dina; Ricardo, Sara; Augusto, Isabel; Schmitt, Fernando. "Evaluation of HER2 in breast cancer: reality and expectations". Expert Opinion on Medical Diagnostics 3 6 (2009): 607-620. http://dx.doi.org/10.1517/17530050903222221. 10.1517/17530050903222221 Ricardo, S. A. V.; Milanezi, F.; Carvalho, S. T.; Leitao, D. R. A.; Schmitt, F. C. L.. "HER2 evaluation using the novel rabbit monoclonal antibody SP3 and CISH in tissue microarrays of invasive breast carcinomas". Journal of Clinical Pathology 60 9 (2006): 1001-1005. http://dx.doi.org/10.1136/jcp.2006.040287. 10.1136/jcp.2006.040287 Ricardo, Sara. "Aberrant P-cadherin expression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter methylation status". FEBS Journal (2005): Published De Matos Granja, N.; Vinhas Ricardo, S.A.; Longatto Filho, A.; Ferreira Alves, V.A.; Bedrossian, C.W.M.; Wiley, E.L.; Schmitt, F.C.. "Potential use of loss of heterozygosity in pleural effusions of breast cancer metastases using the microsatellite marker of the 16q22.1 region of the CDH1 gene". Analytical and Quantitative Cytology and Histology 27 2 (2005): 61-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-17644405813&partnerID=MN8TOARS. Carvalho, S. "c-KIT and PDGFRA in breast phyllodes tumours: overexpression without mutations?". Journal of Clinical Pathology 57 10 (2004): 1075-1079. http://dx.doi.org/10.1136/jcp.2004.016378. 10.1136/jcp.2004.016378 Reis-Filho, J.S.; Ricardo, S.; Gärtner, F.; Schmitt, F.C.. "Bilateral Gonadoblastomas in a Dog with Mixed Gonadal Dysgenesis". Journal of Comparative Pathology 130 2-3 (2004): 229-233. http://dx.doi.org/10.1016/j.jcpa.2003.09.010. 10.1016/j.jcpa.2003.09.010 Cano, Guillerma; Milanezi, Fernanda; Leitão, Dina; Ricardo, Sara; Brito, Maria José; Schmitt, Fernando Carlos. "Estimation of hormone receptor status in fine-needle aspirates and paraffin-embedded sections from breast cancer using the novel rabbit monoclonal antibodies SP1 and SP2". Diagnostic Cytopathology 29 4 (2003): 207-211. http://dx.doi.org/10.1002/dc.10365. 10.1002/dc.10365 Reis-Filho, Jorge S; Preto, Ana; Soares, Paula; Ricardo, Sara; Cameselle-Teijeiro, José; Sobrinho-Simões, Manuel. "p63 Expression in Solid Cell Nests of the Thyroid: Further Evidence for a Stem Cell Origin". Modern Pathology 16 1 (2003): 43-48. http://dx.doi.org/10.1097/01.mp.0000047306.72278.39. 10.1097/01.mp.0000047306.72278.39 Preto, Ana; Reis-Filho, Jorge S.; Ricardo, Sara; Soares, Paula. "P63 Expression in Papillary and Anaplastic Carcinomas of the Thyroid Gland: Lack of an Oncogenetic Role in Tumorigenesis and Progression". Pathology - Research and Practice 198 7 (2002): 449-454. http://dx.doi.org/10.1078/0344-0338-00281. 10.1078/0344-0338-00281
Online resource	Ricardo, Sara. New molecular approaches to improve gynecological cancer management.. 2023. https://books.google.pt/books?hl=pt-PT&lr=&id=LM3JEAAAQBAJ&oi=fnd&pg=PA5&ots=uxqdlUlSYB&sig=1B4iaxunveuHKmiuE6xjVJL617E&redir_esc=y#v=onepage&q&f=false. DOI 10.3389/978-2-8325-2920-1

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2022/11/16	Reciclar as ascites de cancro do ovário descartadas para monitorizar a resistência à terapia	19º Congresso Nacional de Oncologia Sociedade Portuguesa de Oncologia (Porto, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/09/15 - Current	Metabolismo associado à quimioresistência em linhas celulares de cancro do ovário Supervisor	Ciências Biomédicas (Degree) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2023/09/01 - Current	Evaluation of the cytotoxic effect of Galanthamine in a Chemoresistant High-Grade Serous Carcinoma Cell Line Supervisor	Biotecnologia Molecular e Bioengenharia (Master) Universidade de Aveiro, Portugal
2023/03/01 - Current	Synergistic potential of bioactive extracts of wild edible mushrooms from Northeast Transmontano and conventional chemotherapy: A strategy to reverse chemoresistance Co-supervisor	Ciências Biomédicas (PhD) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2022/11/01 - Current	DECIPHERING THE OMENTO IMMUNE SIGNATURE IN ACUTE APPENDICITIS Supervisor	Doutoramento em Ciências Biomédicas (PhD) Instituto Universitário de Ciências da Saúde, Portugal
2022/09/01 - Current	Improving the efficacy of immunotherapy in endometrial cancer patients by combining epigenetic drugs and using patient-derived spheroid cocultures Co-supervisor	Doutoramento em Ciências Biomédicas (PhD) Instituto Universitário de Ciências da Saúde, Portugal
2022/01/01 - Current	Identification of biomarkers in ovarian cancer ascites and disruption of protein function as a therapeutic approach. Supervisor	Medicina e Oncologia Molecular (Master) Universidade do Porto Faculdade de Medicina, Portugal
2021/02/01 - Current	Malignant ascites microenvironment kinetics during ovarian cancer metastization Supervisor	Ciências Biológicas Aplicadas à Saúde (PhD) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2020/11/01 - Current	Drug repurposing as a strategy to overcome ovarian cancer chemoresistence Supervisor	Patologia e Genética Molecular (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/02/01 - 2023/06/30	Comparaçao do Fenotipo de Tumores Primarios e Metastases Peritoneais em Carcinomas Serosos de Alto Grau do Ovario Atraves de um Software de Analise de Patologia Digital Supervisor	Ciências Biomédicas Laboratoriais (Degree) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022/09/09 - 2023/06/30	Evaluation of Chemoresistance Biomarkers in Ovarian Cancer Cell Lines Supervisor	Ciências Biomédicas (Degree) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2021/02/01 - 2021/06/30	Identification of potential biomarkers in ascitic fluids from ovarian cancer patients Supervisor	Bioquímica (Degree) Universidade do Porto Faculdade de Ciências, Portugal
2020/09/20 - 2021/06/30	P-glycoprotein expression analysis in ovarian tumours quimioresistent recurrences Supervisor	Ciências Biomédicas (Degree) Instituto Universitário de Ciências da Saúde, Portugal
2020/03/01 - 2020/09/30	Diagnostic methods in breast cancer Supervisor	Ciências Biomédicas Laboratoriais (Degree) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2020/03/01 - 2020/07/30	Diagnostic methods in ovarian cancer Supervisor	Ciências Biomédicas Laboratoriais (Degree) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2020/03/01 - 2020/07/30	Treatment manedgment in breast cancer Supervisor	Ciências Biomédicas Laboratoriais (Degree) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2020/03/09 - 2020/04/22	Peritoneal Carcinomatosis from ovarian cancer: Identification of biomarkers in the ascitic fluid Supervisor	Estudos Básicos de Medicina (Master) Universidade do Algarve, Portugal
2019 - 2019	First line drug testing in ovarian cancer cell lines manipulated for Mesothelin expression Supervisor	Oncologia (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2016	Mucins MUC16 and MUC1 are major carriers of SLea and SLex in borderline and malignant serous ovarian tumours Supervisor	Medicina (Master) Universidade do Porto Faculdade de Medicina, Portugal
2010 - 2011/07/21	Evaluation of CD147 marker expression in oral cavity carcinomas Co-supervisor	Patologia oral (Master) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2010 - 2011	Evaluation of p73 expression in leukoplakia and reactive lesions of the oral cavity Co-supervisor	Patologia Oral (Master) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2010 - 2011	Evaluation of p56, p63, and Ki-67 expression in Leukoplakia and reactive lesions of the oral cavity Co-supervisor	Patologia Oral (Master) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2010 - 2011	Evaluation of Phospho-mTOR and PTEN expression in oral cavity carcinomas Co-supervisor	Patologia Oral (Master) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2010 - 2011	Evaluation of p53, p63 and p73 expression in odontogenic cysts and tumors Co-supervisor	Patologia Oral (Master) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2016 - Current	Membro da Comissão Organizadora do I Congresso Nacional de Ciências Biomédicas Laboratoriais, Bragança, 28-30 Outubro 2016. (2016/10/28) Congress (Member of the Organising Committee)	Instituto Politécnico de Bragança, Portugal
2008 - Current	Organizing committee of the advanced seminar for “HPV detection: screening and vaccines”. Cupertino de Miranda Foundation, Porto, Portugal. (2008)	Associação Portuguesa de Técnicos de Anatomia Patológica, Portugal
2007 - Current	Organizing Committee of the pre-congress IX Technical Congress of Pathological Anatomy, held at the Escola Superior de Saúde do Vale do Sousa, Gandra, Portugal. (2007)
2007 - Current	President of the Organizing Committee of the IX Technical Congress of Pathological Anatomy, held at the Dr. Cupertino de Miranda Foundation, Porto, Portugal. (2007)
2000 - Current	Member of the organizing committee at the III National Meeting of Health Technologies, organized by the Lisbon Scool of health technology and the Student Association, under the theme “From one century to another… the future”, Lisbon, Portugal. (2000) Congress (Member of the Organising Committee)	Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2022/04/07 - 2022/04/08	Congresso Internacional da TOXRUN 2022 (2022/04/07 - 2022/04/08) Congress (Member of the Organising Committee)	Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2010/06/01 - 2010/06/01	Organizing committee of the advanced seminar “Gynecological Cytology: Basic and Advanced Principles”, at IPATIMUP, Porto, Portugal (2010) Conference (Member of the Organising Committee)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2008 - Current	Internship in Immunohistochemistry at the Advanced Diagnostic Laboratory at the University College of London, London, England. Other	Imunohistoquimica University College of London, United Kingdom
2008 - Current	Training internship in Molecular Biology techniques for HPV detection at the Molecular Biology Department of Radium Hospital, Oslo, Norway. Other	Captura Híbrida e Papillocheck Radiumhospitalet, Norway
2006 - Current	Workshop Detection of HER2 Gene with CISH, IPATIMUP, Porto, Portugal. Workshop	Detection of HER2 Gene with CISH (Chromogenic In Situ Hybridisation) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2005 - Current	Participation in the Workshops on Molecular Biology in HPV: “HPV Conferences: DNA extraction, PCR amplification, hybridization in Hibrimax and interpretation of results”, IPATIMUP, Porto, Portugal. Workshop	Jornadas de HPV: Extracção de DNA, amplificação por PCR, hibridação no Hibrimax e interpretação de resultados Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2003 - Current	Workshop on Hybrid Capture II HPV DNA Test, IPATIMUP, Porto, Portugal. Workshop	Hybrid Capture II HPV DNA Test Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2022/10/27 - 2022/10/30	ESGO's (European Society of Gynecological Oncology) Annual 23th European Congress	European Society of Gynecological Oncology, Switzerland
2015/06/01 - 2015/06/30	Advanced course in Biostatistics and its Applications in Clinical and Epidemiological Research - Institute of Public Health of the University of Porto (ISPUP) Other	Avançado de Bioestatística e suas Aplicações em Investigação Clínica e Epidemiológica Universidade do Porto Instituto de Saúde Pública, Portugal
2014/06/01 - 2014/06/30	Institute of Public Health of the University of Porto (ISPUP) intensive course on Introduction to Biostatistics and its applications in clinical and epidemiological research. Other	Introdução à Bioestatística e suas aplicações em investigação clínica e epidemiológica Universidade do Porto Instituto de Saúde Pública, Portugal
2003/01/23 - 2003/01/25	IV Theoretical-Practical Course in Molecular Biology” held at the Biotechnology Department of the National Institute of Industrial Engineering and Technology, in Lisbon, Workshop	IV Curso Teórico-Prático em Biologia Molecular Instituto Nacional de Engenharia e Tecnologia Industrial, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2023/12/12	Unraveling the role of cell metabolism in the molecular mechanisms of resistance in cancer Encapsulation of glycolytic inhibitors in nanoparticles to increase their release in a lung cancer model Thesis Member	Andrea Teixeira da Cunha (PhD) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2023/07/03	Comparacão do Fenótipo de Tumores Primários e Metástases Peritoneais em Carcinomas Serosos de Alto Grau do Ovário Através de um Software de Análise de Patologia Digital Supervisor	Margarida Matos de Carvalho (Other) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/07/03	Evaluation of Chemoresistance Biomarkers in Ovarian Cancer Cell Lines Supervisor	Anabela Bianca Moreira Costa (Other) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2022/12/02	Quantificação da carga viral de HPV de alto risco e associação com o desenvolvimento de lesões cervicais (Thesis) Main arguer	Telma Sofia Mota Oliveira (Master) Instituto Politécnico do Porto, Portugal Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022/11/23	Evaluation of the expression of ACE-2, TMPRSS2 and furin in endocrine lesions (Thesis) Main arguer	Maria Teresa Mesquita Azevedo (Master) Universidade do Porto Faculdade de Medicina, Portugal
2022/11/04	Therapeutic targeting of spindle assembly checkpoint silencing as a strategy to sensitize cancer cells to chemotherapy drugs Thesis Member	Ana Cristina do Espírito Santo Henriques (PhD) Instituto Universitário de Ciências da Saúde, Portugal
2022/10/25	Unravel the role of P-cadherin expression in ovarian cancer cell lines (Thesis) Main arguer	Inês Morgado de Sá (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2021/07/01	Evaluation of P-Glycoprotein Expression in Recurring Ovarian Tumors Supervisor	Henrique da Silva Ferreira (Other) Instituto Universitário de Ciências da Saúde, Portugal
2021/04/25	Pre-Clinical Evaluation of Targeted Therapies Using 3D Cell Models of Breast Cancer (Thesis) Main arguer	Gonçalo Santos Moura Trindade (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2019	First line drug testing in ovarian cancer cell lines manipulated for Mesothelin expression Supervisor	Mariana Oliveira Nunes (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016	Mucins MUC16 and MUC1 are major carriers of SLea and SLex in borderline and malignant serous ovarian tumours Supervisor	Cristina Lara Fernandes de Pinho Valente (Master) Universidade do Porto Faculdade de Medicina, Portugal
2014	Mitotic checkpoint proteins and oral squamous cell carcinoma: expression levels and prognostic value (Thesis) Main arguer	José Henrique Carvalho Teixeira (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014	Exploring CDC20 gene expression in oral cavity cancer (Thesis) Main arguer	Inês Moranguinho Bastardo Moura (Master) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Committee member

	Activity description Role	Institution / Organization
2021/09/01 - Current	Course Committee for the Degree in Biomedical Sciences Member	Instituto Universitário de Ciências da Saúde, Portugal
2020/09/01 - Current	Committee of Tutors of the Doctoral Program in Biological Sciences Applied to Health Member	Instituto Universitário de Ciências da Saúde, Portugal
2014/09/01 - 2015/02/28	Member of the board in the Laboratory Biomedical Sciences Course at the School of Health of the Polytechnic Institute of Bragança (2014-2015).	Instituto Politécnico de Bragança, Portugal

Conference scientific committee

	Conference name	Conference host
2016 - 2016	I Congresso Nacional de Ciências Biomédicas Laboratoriais	Bragança

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2020/02/01 - Current	Research in Biological Sciences Applied to Health	Ciências Biológicas Aplicadas à Saúde (Doutoramento)	Instituto Universitário de Ciências da Saúde, Portugal
2020/02/01 - Current	Laboratory rotations	Ciências Biológicas Aplicadas à Saúde (Doutoramento)	Instituto Universitário de Ciências da Saúde, Portugal
2019/09/01 - Current	Biopathology	Ciências Biomédicas (Licenciatura)	Instituto Universitário de Ciências da Saúde, Portugal
2019/02/01 - Current	Histology and general embriology	Ciências da Nutrição (Licenciatura)	Instituto Universitário de Ciências da Saúde, Portugal
2018/09/01 - Current	Biopatologia e anatomia patológica	Ciências Biomédicas (Licenciatura)	Instituto Universitário de Ciências da Saúde, Portugal
2017/09/01 - Current	Curso avançado em oncobiologia	Ciências Biológicas Aplicadas à Saúde	Instituto Universitário de Ciências da Saúde, Portugal
2019/09/01 - 2020/07/31	Human genetics	Ciências Biomédicas (Licenciatura)	Instituto Universitário de Ciências da Saúde, Portugal
2019/09/01 - 2020/07/31	Oncobiology	Bioquímica em Saúde (Mestrado integrado)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2020/02/15 - 2020/06/30	Anatomic Pathology	Ciências Biomédicas Laboratoriais (Licenciatura)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2016/09/01 - 2017/07/31	Introdução à investigação em patologia molecular aplicada em oncobiologia	Medicina (Mestrado integrado)	Universidade do Porto Faculdade de Medicina, Portugal
2014/09/01 - 2015/02/28	Systematic Pathological Anatomy	Ciências Biomédicas Laboratoriais (Licenciatura)	Instituto Politécnico de Bragança Escola Superior de Saúde de Bragança, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2013/01/01 - Current	External Assessment evaluation member for the Accreditation of Study Programmes Evaluator	Agência de Avaliação e Acreditação do Ensino Superior, Portugal
2021/09/01 - 2022/12/31	President and member of the External Evaluation Committees for evaluating study cycles in operation in the Diagnostic and Therapeutic Technologies thematic area in 2021 and 2022.	Agency for Assessment and Accreditation of Higher Education - A3ES, Portugal
2021/02/01 - 2021/02/15	CESPU GRANTS 2021, 2022 and 2023 - Research Project Reviewer Evaluator	Cooperativa de Ensino Superior Politécnico e Universitário, Portugal	Cooperativa de Ensino Superior Politécnico e Universitário
2020/08/01 - 2020/09/06	ERC Consolidator Grant 2020 - Project Reviewer Evaluator	European Research Council, Belgium	European Research Council

Journal scientific committee

	Journal title (ISSN)	Publisher
2023/11/01 - Current	Journal of Ovarian Research	Springer Nature
2023/10/29 - Current	Clinical & Experimental Metastasis	SpringerLink
2021/02/01 - Current	Oncogenesis (2157-9024)	Nature
2021/02/01 - Current	Cancer Research (1538-7445)	AACR journals
2020/12/01 - Current	Current Oncology (1718-7729)	MDPI
2020/01/01 - Current	Scientific Letters (ISSN 2795-5117)	IUCS-CESPU, the University Institute of Health Sciences
2019 - Current	Cancers (2072-6694)	MDPI AG
2018 - Current	Genes (2073-4425)	MDPI AG
2017 - Current	International Journal of Molecular Sciences (1422-0067)	MDPI AG
2016 - Current	Acta Histochemica (0065-1281)	Elsevier
2016 - Current	Journal of Clinical Pathology (1472-4146)	BMJ
2016 - Current	Current Cancer Drug Targets (1568-0096)	Bentham Science
2014/03/01 - 2014/06/01	Microarrays (2076-3905)	MDPI

Mentoring / Tutoring

	Topic	Student name
2020/12/01 - Current	Co-targeting of cancer glycolytic metabolism and angiogenesis through polymeric nanoparticles for glioblastoma therapeutics	Ana Catarina da Silva Pacheco
2020/12/01 - Current	3D tumor spheroids as preclinical models to study oral cancer	Mafalda Maria Calheiros Lobo Duarte
2020/09/01 - 2024/09/01	Development and evaluation of berberine nanoparticles as na antimicrobial tool in endodontic irrigation	Célia Marques

Distinctions

Award

2023	Prémio de Produtividade Científica do IUCS-CESPU Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2022	PRÉMIO MELHOR COMUNICAÇÃO ORAL na Categoria Ginecologia (1º lugar), Congresso Nacional de Oncologia . Sociedade Portuguesa de Oncologia, Portugal
2022	Prémio de Produtividade Científica do IUCS-CESPU Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2010	IMPAKT 2010 Travel Grants

Other distinction

2014	Post-Doc Grant - Clinical Medicine Area Fundação para a Ciência e a Tecnologia, Portugal