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In 2008 I completed my PhD in Materials Science and Technology-Biomaterials from the Univ. of Minho, under the supervision of Prof. T. Kokubo (Univ. of Kyoto, Japan) and Prof. R. Reis (Univ. of Minho), developing new approaches for designing bioactive materials for bone repair. During my Master's in Polymer Engineering, I earn my passion for microscopy analysis. I had the opportunity to work with Prof. Atsuo Ito in Japan by studying the formation of a calcium phosphate layer on osteoconductive materials by using in situ atomic force microscopy (AFM). In my postdoctoral studies, I investigated the influence of silanol groups on the osteogenic differentiation of mesenchymal stem cells. Later, I initiated research in chimeric silk proteins with different functionalities, cell adhesion, apatite nucleation, and antibacterial motifs, for their application in tissue engineering and infection control of implants. Multi-scale imaging and analysis methods are crucial to boosting material and life sciences. In the last five years, my focus has been on microscopy and technology development for my research. Under this role, I gained experience with image processing/analysis processing and standard software for electron microscopy and AFM. As a result of the experience acquired, I became head of the microscopy facilities of 3B’s Research Group, provided advanced imaging/analysis tools, and fostered collaborations between the group, universities, and industry. Currently, I am focusing on combining different imaging tools (FIB-SEM, CLEM, AFM) into a unique platform, and in this way, providing new prospects to gain insights on the surface and structural organization of cells, tissue, and their interaction with materials.
Identification

Personal identification

Full name
Isabel Leonor

Citation names

  • Leonor, Isabel B.
  • Leonor, Isabel
  • Leonor, I. B.

Author identifiers

Ciência ID
9419-8783-F00D
ORCID iD
0000-0002-4319-4883
Researcher Id
P-6723-2019
Scopus Author Id
10639148800

Email addresses

  • belinha@i3bs.uminho.pt (Professional)
  • ileonorisabel@gmail.com (Personal)

Websites

Knowledge fields

  • Engineering and Technology - Materials Engineering

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2008 - 2011
Concluded
Post-Doc Fellow in Materials Science and Technology (Pós-doutoramento)
Major in Biomaterials
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2008/01/14
Concluded
Ciência e Tecnologia dos Materiais (Doutoramento)
Major in Especialidade: Biomateriais
Universidade do Minho Escola de Engenharia, Portugal
"New Biomimetic Acellular Routes for Pre-calcification of Implant Materials, Carrier Particles and Porous Scaffolds" (THESIS/DISSERTATION)
Aprovada
2001
Concluded
Dep Eng de Polimeros da Universidade do Minho (Mestrado)
Major in Engenharia de Polímeros
Universidade do Minho Escola de Engenharia, Portugal
"Development of Bioactive Starch-Based Composites and Novel Coating Methodologies to Produce Bioactive Layers on Polymeric Surfaces" (THESIS/DISSERTATION)
Muito Bom
1997
Concluded
Engenharia Metalúrgica e dos Materiais (Licenciatura)
Universidade do Porto Faculdade de Engenharia, Portugal
13
Affiliation

Science

Category
Host institution
Employer
2023/07/05 - 2024/12/31 Auxiliary Researcher (Research) I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Universidade do Minho, Portugal
2020/04/20 - 2023/06/30 Invited Auxiliary Researcher (Research) 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Universidade do Minho, Portugal
2020/04/20 - 2021/09/02 Auxiliary Researcher (Research) 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Universidade do Minho, Portugal
2019/04/01 - 2020/03/31 Invited Auxiliary Researcher (Research) 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Universidade do Minho, Portugal
2018/05/02 - 2019/03/31 Invited Auxiliary Researcher (Research) 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Universidade do Minho, Portugal
2015/10/01 - 2018/05/01 Invited Auxiliary Researcher (Research) 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Universidade do Minho, Portugal
2014/11 - 2015/09/30 Invited Auxiliary Researcher (Research) 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Universidade do Minho, Portugal
2011/09/15 - 2014/11/14 Auxiliary Researcher (Research) Laboratório Associado ICVS 3B's, Portugal
Universidade do Minho, Portugal
2008/01/15 - 2011/09/15 Postdoc (Research) Universidade do Minho Escola de Engenharia, Portugal
Universidade do Minho, Portugal

Others

Category
Host institution
Employer
2019/12 - Current Ciencia Vitae Promoter | Responsible for FCT CV management of 3Bs - Research Group 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Universidade do Minho, Portugal
2015/11/02 - Current Responsible for the laboratory for imaging and X-ray microanalysis. 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Universidade do Minho, Portugal
2022/12/14 - 2022/12/14 Training on Mechanical target pre-preparation for EM with Target Surfacing System (TXP-Leica) 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Leica Microsystems GmbH, Germany
2022/12/13 - 2022/12/13 Training on Critical point dryer (EM CPD300-Leica) 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Leica Microsystems GmbH, Germany
2016/10/17 - 2016/10/20 Advanced Course in Electron CrossBeam® Microscope 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Carl Zeiss AG, Germany
2016/03/07 - 2016/03/09 Basic Course in Electron CrossBeam® Microscope 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Carl Zeiss AG, Germany
2016/02/02 - 2016/02/04 Training on Dimension Icon System from Bruker Corporation 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
AZBIL Telstar Technologies, Spain
2015/10/12 - 2015/10/16 D8 Advance Training X-ray diffraction (XRD), Bruker 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Bruker AXS GmbH, Germany
2014/04/28 - 2014/04/30 Advanced course in Low-Resolution Microscope – JSM-6010LV – JEOL 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Izasa Scientific, A Werfen Company, Spain
2014/03/12 - 2014/03/14 Basic course in Low-Resolution Microscope – JSM-6010LV – JEOL 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Izasa Scientific, A Werfen Company, Spain
2013/07/18 - 2013/07/19 Training on Inductively Coupled Plasma Spectrometer 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Dias de Sousa SA, Portugal
2002/03/01 - 2003/02/28 Bolsa de Assistente de Investigação para Doutoramento - 3B's/BAI-D/2/2002 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Universidade do Minho, Portugal
2001/11/02 - 2002/05/31 Bolsa de Assistente de Investigação para Mestrado - BRITE-ISOBONNE/BAI/5/2001 3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Universidade do Minho, Portugal
2000/04 - 2000/10 Advancing training in operating an Atomic Force Microscope (NanoScope® IIIa, Digital Instruments Inc.), Bionic Design Group National Institute for Advanced Interdisciplinary Research, Japan
National Institute for Advanced Industrial Science and Technology, Japan
Projects

Grant

Designation Funders
2006 - 2008/01/14 PROTEUS – Conversão de recursos naturais e resíduos marinhos em produtos de alto valor acrescentado para aplicação industrial
PhD Student Fellow
Concluded
2002 - 2007 New Biomimetic Acellular Routes for Pre-Calcification of Implant Materials, Carrier Particles and Porous Scaffolds
SFRH / BD / 9031 / 2002
PhD Student Fellow
Universidade do Minho, Portugal
Concluded
1998 - 2001 Development of Bioactive Starch Based Composites and Novel Coating Methodologies to Produce Bioactive Layers on Polymeric Surfaces
NA
Master Student Fellow
Universidade do Minho, Portugal
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 ICVS/3B¿s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos
LA/P/0050/2020
UID/Multi/50026/2019
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2024/12/31 SpyPatch | Modular spider silk and elastin recombinamers for soft tissue repair patches
PTDC/CTM-CTM/2844/2021
PTDC/BTM-MAT/2844/2021
Co-PI
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 ChimericFibre4Tendon - Advanced bio-inspired drug-free materials for tendon-ligament repair
PTDC/BII-BIO/28870/2017
Principal investigator
Universidade do Minho, Portugal

3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2013/06 - 2015/09 ACROSS-Development of AntimiCRObial Spider Silk sutures for preventing surgical site infections
PTDC/BBB-BIO/0827/2012
Principal investigator
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/05 - 2015/09 OSTEOSYNTHESIS - Fabrication of Bioactive Periosteum Membranes for Bone Regeneration Using Innovative Self-assembling and Nanofabrication Approaches
PTDC/CTM-BIO/0814/2012
Researcher
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/10 - 2015/09 POLARIS – Unlocking the research potential of 3Bs Group, University of Minho, in the Nanomedicine field to strengthen its competitive position at the European level
Researcher
Universidade do Minho, Portugal

3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
European Commission Seventh Framework Programme for Research and Technological Development
Concluded
2010/04 - 2013/09 Chimera - Development of new chimeric proteins to be used in the fabrication of a novel biomaterial for bone regeneration application
PTDC/EBB-EBI/109093/2008
Researcher
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 23 - 2011-2012
PEst-OE/EQB/LA0023/2011
PEst-C/SAU/LA0026/2011
Universidade do Minho, Portugal

Universidade do Algarve, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Instituto de Biotecnologia e Bioengenharia, Portugal

Universidade de Trás-os-Montes e Alto Douro, Portugal

Fundação Gaspar Frutuoso, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade dos Açores, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/15 - 2011/09/14 NOVEL APPROACH FOR THE DESIGN OF 3D OSTEOCONDUCTIVE, OSTEOINDUCTIVE AND OSTEOGENIC SCAFFOLDS FOR BONE REGENERATION APPLICATIONS
SFRH/BPD/26648/2006
SFRH / BPD / 26648 / 2006
Post-doc Fellow
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2011/06/30 "MIMESIS - Combination of osteogenic factors with biomimetic methodologies for bone tissue engineering applications"
PTDC/CTM/67560/2006
Post-doc Fellow
Universidade do Minho, Portugal

3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/12/01 - 2010/12/31 NanoBioactive - bioactive materials containing new bioglass nanoparticles for biomedical applications
PTDC/QUI/69263/2006
PhD Student Fellow
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2004 - 2010 EXPERTISSUES-Novel Therapeutic Strategies for Tissue Engineering of Bone and Cartilage Using Second Generation Biomimetic Scaffolds
PhD Student Fellow
Universidade do Minho, Portugal
Concluded
2006 - 2009 InVENTS - An Integrated Series of Events for High-level Training on Biomaterials, Tissue Engineering, Controlled Drug Delivery and Related Emerging Fields
PhD Student Fellow
Universidade do Minho, Portugal
European Commission Sixth Framework Programme
Concluded
2004 - 2008 HIPPOCRATES - A Hybrid Approach and Cartilage Tissue Engineering using Natural Origin Scaffolds, Progenitor Cells and Growth Factors
PhD Student Fellow
Universidade do Minho, Portugal
Concluded
2002/10/01 - 2006/09/30 NEW BIOMIMETIC ACELLULAR ROUTES FOR PRE- CALCIFICATION OF DEGRADABLE FIBRES AND POROUS SCAFFOLDS IN SIMULATED BODY FLUIDS
SFRH/BD/9031/2002
Fundação para a Ciência e a Tecnologia
Concluded
2003/04/01 - 2006 BIOLEARN - Learning from Nature How to Design Biomimetic Routes for Producing Calcium-Phosphate Coatings on Polymeric Biomaterials
PhD Student Fellow
Universidade do Minho, Portugal

3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Fundação para a Ciência e a Tecnologia
Concluded
1998 - 2005 Novel Starch/Bioglass® Composites - US Biomaterials corporation
NA
Master Student Fellow
Universidade do Minho, Portugal

3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Concluded
1998 - 2002 ISOBONE - A Tissue Engineered Living Bone Equivalent
Master Student Fellow
Universidade do Minho, Portugal

3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
Concluded
Outputs

Publications

Book chapter
  1. Leonor, I.B.; Rodrigues, A.I.; Reis, R.L.. "Designing biomaterials based on biomineralization for bone repair and regeneration". In Biomineralization and Biomaterials, edited by Aparicio, C.; Ginebra, M. P., 377-404. Elsevier, 2016.
    Published • 10.1016/b978-1-78242-338-6.00014-4
  2. Gomes, Sílvia; Leonor, Isabel B.; Mano, João F.; Reis, Rui L.; Kaplan, David L.. "Silk-Based Biomaterials". In Biomimetic Approaches for Biomaterials Development, edited by Mano, J. F., 75-92. Wiley-VCH Verlag GmbH & Co. KGaA, 2012.
    10.1002/9783527652273.ch4
  3. LEONOR, I.B.; GOMES, S.; BESSA, P.C.; MANO, J.F.; REIS, R.L.; CASAL, M.. "New biomineralization strategies for the use of natural-based polymeric materials in bone-tissue engineering". In Natural-Based Polymers for Biomedical Applications, edited by Reis, Rui L., 193-230. Elsevier, 2008.
    Published • 10.1533/9781845694814.2.193
  4. Azevedo, H.S.; Leonor, Isabel B.; Reis, Rui L.. "Incorporation of Proteins with Different Isoelectric Points into Biomimetic Ca-P Coatings: A New Approach to Produce Hybrid Coatings with Tailored Properties". In Bioceramics 18, edited by Nakamura, T.; Yamashita, K.; Neo, M., 755-758. Trans Tech Publications Ltd., 2006.
    Published • 10.4028/0-87849-992-x.755
  5. Leonor, Isabel B.; Balas, Francisco; Kawashita, Masakazu; Reis, Rui L.; Kokubo, Tadashi; Nakamura, Takashi. "Biomimetic Apatite Formation on Different Polymeric Microspheres Modified with Calcium Silicate Solutions". In Bioceramics 18, edited by Nakamura, T.; Yamashita, K.; Neo, M., 279-282. Trans Tech Publications Ltd., 2006.
    Published • 10.4028/0-87849-992-x.279
  6. Leonor, Isabel B.; Balas, Francisco; Kim, H.-M.; Kawashita, Masakazu; Reis, Rui L.; Kokubo, Tadashi; Nakamura, Takashi. "Bone-Like Apatite-Forming Ability of Different Polymeric Biomaterials Modified with -SO3H Groups". In III International Materials Symposium, 966-969. Trans Tech Publications Ltd., 2006.
    Published • 10.4028/0-87849-992-x.279
  7. Costa, S.A.; Oliveira, J. Miguel; Leonor, Isabel B.; Reis, Rui L.. "Carboxymethylchitosan/Calcium Phosphate Hybrid Materials Prepared by an Innovative Auto-Catalytic Co-Precipitation Method". In Bioceramics 17, edited by Li, P.; Colwell, C., 701-704. Trans Tech Publications Ltd., 2005.
    Published • 10.4028/0-87849-961-x.701
  8. Oliveira, J. Miguel; Leonor, Isabel B.; Reis, Rui L.. "Preparation of Bioactive Coatings on the Surface of Bioinert Polymers through an Innovative Auto-Catalytic Electroless Route". In Bioceramics 17, edited by Li, P.; Colwell, C., 203-206. Trans Tech Publications Ltd., 2005.
    Published • 10.4028/0-87849-961-x.203
  9. Leonor, Isabel B.; Kim, Hyun Min; Balas, Francisco; Kawashita, Masakazu; Reis, Rui L.; Nakamura, Takashi. "Surface Charge of Bioactive Polyethylene Modified with –SO3H Groups and Its Apatite Inducing Capability in Simulated Body Fluid". In Bioceramics 17, 453-456. Trans Tech Publications Ltd., 2005.
    Published • 10.4028/0-87849-961-x.453
  10. Azevedo, Helena; Reis, Rui. "Understanding the Enzymatic Degradation of Biodegradable Polymers and Strategies to Control Their Degradation Rate". In Biodegradable Systems in Tissue Engineering and Regenerative Medicine. CRC Press, 2004.
    10.1201/9780203491232.ch12
  11. Leonor, I; Azevedo, Helena; Alves, Catarina; Reis, Rui. "Biomimetic Coatings, Proteins and Biocatalysts: a New Approach to Tailor the Properties of Biodegradable Polymers". In Biodegradable Systems in Tissue Engineering and Regenerative Medicine, 223-250. CRC Press, 2004.
    10.1201/9780203491232.ch14
  12. Leonor, I; Sousa, R; Reis, Rui. "Development of Bioactive Composites Based on Biodegradable Systems for Bone Replacement Applications". In Biodegradable Systems in Tissue Engineering and Regenerative Medicine, edited by Reis, Rui L.; Roman, J. S., 115-126. CRC Press, 2004.
    Published • 10.1201/9780203491232.ch8
  13. Leonor, I. B.; Azevedo, H. S.; Pashkuleva, I.; Oliveira, A. L.; Alves, C. M.; Reis, R. L.. "Learning from Nature How to Design Biomimetic Calcium-Phosphate Coatings". In Learning from Nature How to Design New Implantable Biomaterialsis: From Biomineralization Fundamentals to Biomimetic Materials and Processing Routes, edited by Reis, Rui L.; Weiner, S., 123-150. Kluwer Academic Publishers, 2004.
    Published • 10.1007/1-4020-2648-x_8
  14. Leonor, Isabel B.; Oliveira, A. L.; Reis, R. L.. "Recubrimientos biomimeticos". In Biomateriales, edited by Sastre R.; de Aza S.; San Román J., 307-322. Faenza Editrice, Ibérica S.L, 2003.
    Published
  15. Leonor, Isabel B.; Azevedo, H. S.; Alves, C. M.; Reis, R. L.. "Effects of the Incorporation of Proteins and Active Enzymes on Biomimetic Calcium-Phosphate Coatings". In Bioceramics 15, 97-100. Trans Tech Publications, 2003.
    Submitted
  16. Oliveira, A. L.; Leonor, I. B.; Elvira, C.; Azevedo, M. C.; Pashkuleva, I.; Reis, R. L.. "Surface Treatments and Pre-Calcification Routes to Enhance Cell Adhesion and Proliferation". In Polymer Based Systems on Tissue Engineering, Replacement and Regeneration, edited by Reis, Rui L.; Cohn, D., 183-217. Springer Netherlands, 2002.
    Published • 10.1007/978-94-010-0305-6_12
  17. Leonor, Isabel B.; Ito, A.; Onuma, K.; Kanzaki, N.; Reis, Rui L.. "Atomic Force Microscopy as a Tool to Study In-Situ the In-Vitro Bioactivity of Starch Thermoplastic/Hydroxylapatite Biomaterials". In Bioceramics 14, edited by Brown, S.; Clarke, I.; Williams, P., 55-60. Trans Tech Publications, 2001.
    Published
  18. Leonor, Isabel B.; Ito, A.; Onuma, K.; Kanzaki, N.; Zhong, Z.; Greenspan, D.; Reis, Rui L.. "In Situ AFM Study of the Mechanisms Involved on Calcium-Phosphate Film Formation on Partially Crystallized Bioglass and on Hydroxylapatite Immersed in a Simulated Body Fluid". In Bioceramics 14, edited by Brown, S.; Clarke, I.; Williams, P., 291-294. Trans Tech Publications, 2001.
    Published
  19. Leonor, Isabel B.; Reis, Rui L.. "A Novel Auto-Cataltic Deposition Methodology to Produce Calcium-Phosphate Coatings on Polymeric Biomaterials". In Bioceramics 13, edited by Giannini, S.; Moroni, A., 83-86. Trans Tech Publications, 2000.
    Published
  20. Leonor, Isabel B.; Sousa, R. A.; Cunha, A. M.; Zhong, Z.P.; Greenspan, D.; Reis, Rui L.. "Development of highly bioactive and mechanically strong starch thermoplastic/Bioglass composite biomaterials". In Bioceramics 13, edited by Giannini, S.; Moroni, A., 705-708. Trans Tech Publications, 2000.
    Published
  21. Reis, Rui L.; Leonor, Isabel B.; Cunha, A. M.; Fernandes, M. H.; Correia, R. N.. "Mastering the Surface of Bioactive Glass Filled Polyethylene Matrix Composites For Enhancing its In-Vitro Bioactivity". In Bioceramics 12, edited by Ohgushi, H.; Hastings, G. W.; Yoshikawa, T., 405-408. World Scientific Pub., 1999.
    Published
  22. Reis, Rui L.; Leonor, Isabel B.; Rego, M. T.; Cunha, A. M.; Fernandes, M. H.. "Stiff and Bioactive Composites based on Starch, Polyethylene e SiO2-3CaO.P2O5-MgO Glasses and Glass-ceramics". In Bioceramics 11, 169-172. World Scientific Pub., 1998.
    Published
Conference abstract
  1. Casanova, Marta R.; Albina Cristina Ribeiro Franco; Martins, Albino; Leonor, Isabel B.; Reis, Rui L.. "Bioengineered spider silk immobilized on a nanofibrous mesh inhibit bacteria adherence and anticipate new prospects for abdominal muscle tissue repair". Paper presented in Tissue Engineering and Regenerative Medicine International Society-European Chapter Meeting (TERMIS EU), Manchester, 2023.
    Accepted
  2. Albina Cristina Ribeiro Franco; Bakht, Syeda Mahwish; Rodrigues, Márcia T.; Gomez-Florit, Manuel; Domingues, Rui M. A.; Leonor, Isabel B.; Reis, Rui L.; Manuela E. Gomes. "Engineered spider silk hybrid proteins with transforming growth factor b3 modulates stem cell response and anticipate new prospects for tendon repair". Paper presented in 32nd Annual Conference of the European Society for Biomaterials, Bordeaux, 2022.
    Accepted
  3. Albina Cristina Ribeiro Franco; Costa-Almeida, Raquel; Babo, P.; Leonor, Isabel B.; Gomes, M. E. (671B-1C51-BC13); Reis, Rui L.. "Exploring the antibacterial mechanism of action by platelet lysate patches". Paper presented in Tissue Engineering International Regenerative Medicine Society – European Chapter Meeting, Rhodes, 2019.
    Published
  4. Costa-Almeida, Raquel; Albina Cristina Ribeiro Franco; Leonor, Isabel B.; Pesqueira, T.; Babo, Pedro; Reis, Rui L.; Manuela E. Gomes. "A platelet lysate antibacterial bioactive patch for tendon repair". Paper presented in Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Meeting, Davos, 2017.
    Accepted
  5. Albina Cristina Ribeiro Franco; Pirraco, R. P.; Leonor, Isabel B.; Kaplan, David L.. "Biological response of silkbased fibers functionalized with antimicrobial peptides by mimicking bacterial infection in vivo". Paper presented in Tissue Engineering International Regenerative Medicine Society – European Chapter Meeting, Davos, 2017.
    Published
  6. Ribeiro, S. C.; Ferreira, D. S.; Pirraco, R. P.; Leonor, Isabel B.; Reis, Rui L.; Mata, A.; Azevedo, H. S.. "Self-assembled bioactive membranes for bone regeneration". Paper presented in 10th World Biomaterials Congress, Montréal, 2016.
    Published
  7. Albina Cristina Ribeiro Franco; Rodrigues, F.; Leonor, Isabel B.; Reis, Rui L.; Kaplan, David L.. "Exploring Silk Based Biomaterials Functionalized With Antimicrobial Peptides To Prevent Surgical Site Infections". Paper presented in 4th TERMIS World Congress, Boston, 2015.
    Published
  8. Rodrigues, A.I.; Albina Cristina Ribeiro Franco; Rodrigues, F.; Castro, A. G.; Leonor, Isabel B.; Reis, Rui L.. "Antibacterial Effect of Bioactive Starch-based Scaffolds Functionalized with Silanol Groups". Paper presented in 27th Meeting of the European Society For Biomaterials, Kraków, 2015.
    Published
  9. Requica, J. F.; Leonor, Isabel B.; Muñoz, F.; Moura, T.; Carvalho, P.; Anjos, M.; Azevedo, J.; et al. "Development of a new approach to the periodontal regeneration” 101st FDI Annual World Dental Congress, Istanbul, Turkey, August 2013, oral, International Dental Journal 63 (suppl. 1):". Paper presented in 101st FDI Annual World Dental Congress, Turkey, Istanbul, 2013.
    Published
  10. Requicha, J. F.; Leonor, Isabel B.; Muñoz, F.; Azevedo, J.; Viegas, C. A.; Reis, Rui L.; Gomes, M. E. (671B-1C51-BC13). "A novel tissue engineering concept targeting the regeneration of periodontal defects.". Paper presented in European Chapter of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) 2013 Annual Meeting, Turkey, 2013.
    Published
  11. Requicha, J. F.; Moura, T.; Muñoz, F.; Leonor, Isabel B.; Gomes, M. E. (671B-1C51-BC13); Reis, Rui L.; Viegas, C.A.. "Assessment of a scaffold for periodontal regeneration in a rodent model". Paper presented in XXII European Congress of Veterinary Dentistry and XII World Veterinary Dental Congress, Prague, 2013.
    Published
  12. Requica, J. F.; Leonor, Isabel B.; Viegas, C. A.; Reis, Rui L.; Gomes, M. E. (671B-1C51-BC13). "Tissue engineered constructs for periodontal regeneration based on adipose stem cells and a newly designed polymeric scaffold". Paper presented in XXXVIII Annual ESAO & IV Biennial IFAO Congress, Porto, 2011.
    Published
  13. Ferreira, M. E.; Leonor, Isabel B.; Gomes, S.; Mano, J.F.; Reis, Rui L.; Kaplan, David L.. "Spider silk functionalized with human antimicrobial peptides as a novel chimeric protein for tissue engineering applications". Paper presented in XXXVIII Annual ESAO & IV Biennial IFAO Congress, Porto, Portugal, October 2011, Porto, 2011.
    Published
  14. Requicha, J. F.; Leonor, Isabel B.; Albuquerque, C. M.; Gomes, M. E. (671B-1C51-BC13); Reis, Rui L.; Viegas, C. A.. "New biodegradable membrane for periodontal tissue engineering". Paper presented in XX European Congress of Veterinary Dentistry, Chalkidiki, September 2011, Chalkidiki, 2011.
    Published • 10.15445/01012014.07
  15. Susano, M.; Frias, A. M.; Leonor, Isabel B.; Reis, Rui L.; Azevedo, H. S.. "Biodegradable Fiber-Mesh Scaffolds with Elastic Properties and Their Potential Use in Tissue Engineering". Paper presented in 24th Meeting of the European Society For Biomaterials, Dublin, 2011.
    Published
  16. Susano, M.; Leonor, Isabel B.; Reis, Rui L.; Azevedo, H. S.. "Elastic biodegradable fibre-mesh scaffolds coated with biomimetic calcium phosphate (CaP) layers for protein delivery". Paper presented in Tissue Engineering International Regenerative Medicine Society – European Chapter Meeting, Granada, 2011.
    Published
  17. Requicha, J. F.; Leonor, Isabel B.; Viegas, C. A.; Reis, Rui L.; Gomes, M. E. (671B-1C51-BC13). "Biodegradable double layer scaffold for periodontal engineering". Paper presented in Tissue Engineering International Regenerative Medicine Society – European Chapter Meeting, Granada, 2011.
    Published
  18. Rodrigues, Ana I.; Gomes, Manuela E.; Leonor, Isabel B.; Reis, Rui L.. "In vitro evaluation of osteoconductive starch based scaffolds under dynamic conditions". Paper presented in Tissue Engineering International Regenerative Medicine Society – European Chapter Meeting, Granada, 2011.
    Published • 10.1109/enbeng.2011.6026083
  19. Susano, M.; Leonor, Isabel B.; Reis, Rui L.; Azevedo, H. S.. "Hybrid scaffolds for the delivery of multiple proteins in bone tissue engineering". Paper presented in 35th Annual Meeting of the Society for Biomaterials, Seatle, 2010.
    Published
  20. Rodrigues, M. T.; Leonor, Isabel B.; Viegas, C. A.; Dias, I. R.; Gomes, M. E. (671B-1C51-BC13); Reis, Rui L.. "Osteoconductive scaffolds obtained by means of in situ surface Functionalization of Wet-Spun Fibre Meshes for Bone Regeneration Applications". Paper presented in Tissue Engineering International Regenerative Medicine Society – European Chapter Meeting, Porto, 2008.
    Published
  21. Leonor, Isabel B.; Kim, H.-M.; Kawashita, M.; Kokubo, T.; Reis, Rui L.. "Novel Methodologies for Designing Bioactive Materials for Bone Applications through by Surface Functionalization". Paper presented in 8th World Biomaterials Congress, Amsterdam, 2008.
    Published
  22. Rodrigues, M. T.; Leonor, Isabel B.; Viegas, C.A.; Dias, I. R.; Gomes, M. E. (671B-1C51-BC13); Reis, Rui L.. "Novel In Situ Approach for the Design of Osteoconductive and Osteoinductive 3D Wet-Spun Fibre Mesh Scaffolds for Bone Tissue Engineering". Paper presented in Tissue Engineering International Regenerative Medicine Society – Asia-Pacific Chapter Meeting, Tokyo, 2007.
    Published
  23. Leonor, Isabel B.; Pedro, A. J.; Tuzlakoglu, K.; Kawashita, M.; Kokubo, T.; Reis, Rui L.. "In Situ Functionalization of 3D-Wet-Spun Fibre Meshes for Bone Regeneration Applications". Paper presented in 21st Meeting of the European Society For Biomaterials, Brighton, 2007.
    Published
  24. Araujo, J. V.; Martins, A.; Leonor, Isabel B.; Pinho, E. D.; Reis, Rui L.; Neves, N.M.. "Surface Controlled Biomimetic Coating of Polycaprolactone Nanofiber Mesh Architectures". Paper presented in Tissue Engineering and Regenerative Medicine International Society – European Chapter, London, 2007.
    Published • 10.1109/ipps.1993.262777
  25. Pereira, R. C.; Mangan, R.; Azevedo, H. S.; Leonor, Isabel B.; Reis, Rui L.. "An Alternative Approach for the Incorporation of Biocatalytic Active Proteins into Biomimetic Ca-P Coatings Rendering them Enhanced Functionalities”,". Paper presented in 20th Meeting of the European Society For Biomaterials, Nantes, 2006.
    Published
  26. Martins, A. M.; Pereira, R. C.; Salgado, A. J.; Azevedo, H. S.; Leonor, Isabel B.; Reis, Rui L.. "Chitosan Scaffolds Incorporating Lysozyme into Ca-P Biomimetic Coatings: Scaffolds for Tissue Regeneration Combining a Self-Regulating Degradation System with In-situ Pore Formation and Carrier Properties". Paper presented in Regenerate World Congress on Tissue Engineering and Regenerative Medicine, Pittsburgh, 2006.
    Published
  27. Martins, A. M.; Salgado, A. J.; Azevedo, H. S.; Leonor, Isabel B.; Reis, Rui L.. "Lysozyme incorporation in biomimetic coated chitosan scaffolds: development and behaviour in contact with osteoblastic-like cells". Paper presented in 8th Tissue Engineering Society International – 8th TESI, Shanghai, 2005.
    Published
  28. Leonor, Isabel B.; Kim, H.-M.; Balas, F.; Kawashita, M.; Reis, Rui L.; Kokubo, T.; Nakamura, T.. "Very Simple Alkaline Treatments To Render Starch Based Degradable Polymers Self-Mineralizable". Paper presented in 19th Meeting of the European Society For Biomaterials, Sorrento, 2005.
    Published
  29. Azevedo, H. S.; Leonor, Isabel B.; Pereira, R. C.; Reis, Rui L.. "Biomimetic Calcium-Phosphate Coatings as Carriers of Bioactive Proteins: Incorporation, Dissolution and Release Studies". Paper presented in 30th Annual Meeting of the Society for Biomaterials, Memphis, 2005.
    Published
  30. Martins, A. M.; Azevedo, H. S.; Leonor, Isabel B.; Reis, Rui L.. "Chitosan scaffolds incorporating degradative enzymes into biomimetic Ca-P coatings able to tailor the degradation rate". Paper presented in 30th Annual Meeting of the Society for Biomaterials, Memphis, 2005.
    Published
  31. Azevedo, H. S.; Leonor, Isabel B.; Alves, C. M.; Goldsmith, R.J.; Reis, Rui L.. "Influence of Protein Incorporation in the Nucleation and Growth of Biomimetic Calcium Phosphate Coatings". Paper presented in 7th World Biomaterials Congress, Sydney, 2004.
    Published
  32. Leonor, Isabel B.; Balas, F.; Kim, H.-M.; Reis, Rui L.; Kokubo, T.; Nakamura, T.. "Apatite-forming ability of polymers with SO3H groups in SBF". Paper presented in 18th Meeting of the European Society For Biomaterials, Stuttgart, 2003.
    Published
  33. Balas, F.; Kim, H.-M.; Leonor, Isabel B.; Reis, Rui L.; Kokubo, T.; Nakamura, T.. "Apatite-forming Ability of Organic Polymeric Biomaterials Modified with SO3H Groups". Paper presented in Annual Meeting of The Ceramic Society of Japan, Tokyo, 2003.
    Published
  34. Leonor, Isabel B.; Reis, Rui L.. "A Novel Electroless Deposition Methodology to Produce Calcium-Phosphate Coatings on the Surface of Polymeric Biomaterials". Paper presented in 16th Meeting of the European Society For Biomaterials, London, 2001.
    Published
Conference paper
  1. El-Guendouz, Soukaina; Lyoussi, Badiaa; Lourenço, João P.; Rosa Costa, Ana M.; Miguel, Maria G.; Dias, Cristina M.B.; Manhita, Ana C.; et al. "Magnetite nanoparticles functionalized propolis extract as nano-antibiotics against methicillin resistant strains of Staphylococcus aureus". 2018.
Conference poster
  1. Albina Cristina Ribeiro Franco; Bakht, Syeda Mahwish; Rodrigues, Márcia; Gomez-Florit, Manuel; Domingues, Rui M. A.; Leonor, Isabel B.; Reis, Rui L.; Manuela E. Gomes. "Using functionalized spider silk proteins to direct stem cells toward tendon cellular differentiation". Paper presented in Achilles Conference, 2022.
  2. Albina Cristina Ribeiro Franco; Casanova, Marta R.; Cruz-Moreira, Daniela; Martins, Albino; Neves, Nuno M.; Leonor, Isabel B.; Reis, Rui L.. Corresponding author: Albina Cristina Ribeiro Franco. "Functionalization of Surgical Meshes with bioengineered spider silk proteins to impair surgical site infections". Paper presented in TERMIS - EU Meeting 2022, 2022.
  3. Albina Cristina Ribeiro Franco; Casanova, Marta R.; Neves, Nuno M.; Leonor, Isabel B.; Reis, Rui L.. "Exploitation of the potential of the functionalization of surgical meshes with bioengineered spider silk proteins to impair surgical site infections". Paper presented in Tissue Engineering International Regenerative Medicine Society - European Chapter Meeting (TERMIS-EU), 2022.
  4. Costa-Almeida, Raquel; Franco, Albina R.; Leonor, Isabel B.; Babo, Pedro S; Reis, Rui L.; Gomes, Manuela E.. "Platelet Lysate Membranes with Antibacterial Potential for Tendon Regeneration". Paper presented in Chem2Nature Second School, 2017.
  5. Costa-Almeida, Raquel; Albina Cristina Ribeiro Franco; Leonor, Isabel B.; Babo, P.; Reis, Rui L.; Gomes, M. E. (671B-1C51-BC13); Pesqueira, T.; Pesqueira, Tamagno; Leonor, I. B.. "Antibacterial potential of platelet lysate membranes for orthopaedic applications". Paper presented in Society for Biomaterials (SFB) 2017 Annual Meeting & Exposition, Minnesota, 2017.
    10.1055/s-0038-1652199
  6. Pereira, Ana Margarida; Machado, Raul; Bernardo, Telma; da Costa, André; Ribeiro, Artur; Collins, Tony; Gomes, Andreia Castro; et al. "Silk-based biomaterials with improved cell adhesion properties". Paper presented in XIX Congresso Nacional de Bioquímica SPB2016, 2016.
  7. Babo, Pedro S; Pires, Ricardo L.; Franco, Albina R.; Rodrigues, F.; Leonor, Isabel B.; Reis, Rui L.; Gomes, Manuela E.. "Platelet Lysate-Loaded Hyaluronic Acid Hydrogels Exhibit Mitogenic and Anti-Microbial Properties". Paper presented in E-MRS Spring Meeting and Exhibit, 2016.
  8. Albina Cristina Ribeiro Franco; Leonor, Isabel B.; Kaplan, David L.; Reis, Rui L.. "Silk fibroin-spider silk-like protein biomaterials for preventing microbial infections". Paper presented in 10th World Biomaterials Congress, 2016.
  9. Pereira, Ana Margarida; Machado, Raul; Bernardo, Telma; da Costa, André; Ribeiro, A.; Collins, Tony; Gomes, Andreia C.; et al. "Silk-based polymers functionalized with fibronectin type-II for improved cell adhesion.". Paper presented in III Symposium PDBMA, Braga, Portugal, 2015.
  10. Babo, P.; Pires, R. L.; Albina Cristina Ribeiro Franco; Santos, L.; Rodrigues, F.; Leonor, Isabel B.; Reis, Rui L.; Gomes, M. E. (671B-1C51-BC13). "Photocrosslinkable Hyaluronan Hydrogels Incorporating Platelets Lysate for Periodontal Tissue Regeneration Exhibit Mitogenic and Anti-microbial Properties". Paper presented in 4th TERMIS World Congress, 2015.
    10.1109/enbeng.2011.6026083
  11. Rodrigues, A. I.; Leonor, Isabel B.; Reis, Rui L.; van Blitterswijk, C. A.; Habibovic, P.. "Calcium and silicon involvement in the osteogenic behavior of hMSCs". Paper presented in Tissue Engineering International Regenerative Medicine Society – European Chapter Meeting, 2014.
  12. Requicha, J. F.; Leonor, Isabel B.; Munoz, F.; Reis, Rui L.; Gomes, M. E. (671B-1C51-BC13); Viegas, C. A.. "New tissue-engineered matrix for periodontal regeneration based on a biodegradable material combined with canine adipose-derived stem cells”". Paper presented in VI Congress Portuguese Society for Veterinary Sciences (SPCV), 2014.
  13. Rodrigues, A. I.; Oliveira, M. B.; Mano, J. F.; Gomes, M. E. (671B-1C51-BC13); Leonor, Isabel B.; Reis, Rui L.. "Synergistic Effect of Silicon and Calcium Ions on Osteogenic Differentiation of Human Adipose Stem Cells". Paper presented in Annual Meeting of the Society for Biomaterials, 2013.
  14. Santos, T. C.; Cerqueira, M. T.; Silva, A. C.; Rodrigues, A. I.; Leonor, Isabel B.; Marques, A. P.; Castro, A. G.; Reis, Rui L.. "Immunomodulatory potential of tissue engineered constructs based on human adipose-tissue derived stem cells and starch-based scaffolds". Paper presented in 3rd TERMIS World Congress 2012 “Tissue Engineering and Regenerative Medicine”, 2012.
  15. Balmayor, E. R.; Keibl C.; Payr, S.; Zanoni, G.; Tangl, S.; Leonor, Isabel B.; Azevedo, H. S.; Reis, Rui L.; van Griensven, M.. "In vitro and in vivo bone regeneration induced by encapsulated bmp-2". Paper presented in Tissue Engineering International Regenerative Medicine Society – European Chapter Meeting, 2011.
  16. Requicha, J. F.; Shanetsh, H.; Leonor, Isabel B.; Viegas, C. A.; Reis, Rui L.; Gomes, M. E. (671B-1C51-BC13). "Characterization of canine adipose derived stem cells and its potential in periodontal tissue engineering applications". Paper presented in 6th International Meeting of the Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC), 2011.
  17. GOMES, S.; Leonor, Isabel B.; Mano, J. F.; Reis, Rui L.; Kaplan, David L.. "Chimeric protein containing spider silk and bone sialoprotein for bone regeneration". Paper presented in Tissue Engineering International Regenerative Medicine Society – North America Conference, 2010.
  18. Leonor, Isabel B.; Rodrigues, M.T.; Gomes, M.E.; Reis, R. L.. "In Situ Functionalization Approach for the Design of 3D Osteoconductive Scaffolds for Bone Regeneration". Paper presented in Gordon Research Conference on Biomaterials: Biocompatibility / Tissue Engineering: “The Engineering Of Healing: From Molecular Mediation To Tissue Constructs, 2009.
  19. Márcia Teresa da Silva Rodrigues; Leonor, Isabel B.; viegas, Carlos A. A.; Dias, Isabel R.; Gomes, Manuela E.; Reis, Rui L.. "Bioactive 3D Wet-Spun Fibre Meshes for Bone Regeneration obtained Using a Simple One-Step Methodology". Paper presented in 6th Marie Curie Cutting Edge InVents Conference, 2008.
  20. Gomes, S.; Rodrigues, M. T.; Leonor, Isabel B.; Gomes, M. E. (671B-1C51-BC13); Mano, J.F.; Reis, Rui L.. "Conversion of Corallina officinalis into calcium phosphates by using hydrothermal treatment and their potential for Bone Tissue Engineering application". Paper presented in Tissue Engineering International Regenerative Medicine Society – European Chapter Meeting 2008, Porto, Portugal, June 2008, 2008.
    10.1109/ultsym.2006.161
  21. Walsh, P. J.; Buchanan, F. J.; Walker G. M.; Dring, M.; Leonor, Isabel B.; Reis, Rui L.. "A Novel Tri-Phasic Technique for Multi-Scale Porosity Enhanced with Natural Corallina Hydroxyapatite". Paper presented in 21st Meeting of the European Society For Biomaterials, Brighton, UK, September 2007, p. 245, poster, 2007.
  22. Gomes, Sílvia; Rodrigues, Márcia T.; Oliveira, Joaquim Miguel; Gomes, Manuela E.; Leonor, Isabel B.; Mano, João F.; Reis, Rui L.. "Hydrothermal Conversion Of Corallina officinalis Algae Into Calcium Phosphate Scaffolds For Bone Tissue Engineering Strategies". Paper presented in 3rd Marie Curie Cutting-Edge Conference “Biomineralisation of polymeric materials, bioactive biomaterials and biomimetic methodologies, 2007.
  23. Wash, P. J.; Buchanan, F. J.; Walker G. M.; Dring, M.; Maggs, C. A.; Leonor, Isabel B.; Reis, Rui L.. "Freeze-drying of Chitosan-PCL blends impregnated with microporous hydroxyapatite from algae origins". Paper presented in 32nd Annual Meeting of the Society for Biomaterials, Chicago, Illinois, USA, 2007.
  24. Leonor, Isabel B.; Mangan, R.; Pereira, R. C.; Azevedo, H. S.; Reis, Rui L.. "Influence of Enzyme Incorporation and Operating Parameters on the Formation of Biomimetic Calcium-Phosphate Coatings on Degradable Starch-based Substrates". Paper presented in Regenerate World Congress on Tissue Engineering and Regenerative Medicine, 2006.
    10.1063/1.4966496
  25. Oliveira, J. M.; Costa, S. A.; Leonor, Isabel B.; Mano, J. F.; Reis, Rui L.. "Development and Characterization of Novel Carboxymethyl-Chitosan/Calcium-Phosphate Tissue Engineering Scaffolds". Paper presented in 19th Meeting of the European Society For Biomaterials, 2005.
  26. Pereira, R. C.; Leonor, Isabel B.; Azevedo, H. S.; Reis, Rui L.. "Effect of Protein Incorporation on the Dissolution Behaviour of Biomimetic Calcium-Phosphate Coatings". Paper presented in 19th Meeting of the European Society For Biomaterials, 2005.
  27. Azevedo, H. S.; Leonor, Isabel B.; Reis, Rui L.. "Proteins Incorporated Into Biomimetic Calcium-Phosphate Coatings are Able to Modulate the Ca-P Layers Properties". Paper presented in 6th International Symposium on Frontiers in Biomedical Polymers, 2005.
  28. Leonor, Isabel B.; Malafaya, P.B.; Baran, E. T.; Kawashita, M.; Reis, Rui L.; Kokubo, T.; Nakamura, T.. "Growth of a Bonelike Apatite Layer on Chitosan Microparticles After a Calcium Silicate Treatment". Paper presented in 7th World Biomaterials Congress, Sydney, Australia, 2004.
  29. Leonor, Isabel B.; Balas, F.; Kim, H.-M.; Reis, Rui L.; Kokubo, Tadashi; Nakamura, T.. "In-Vitro Apatite-Forming Ability of HMWPE Polymeric Biomaterials Modified with SO3H Groups in SBF". Paper presented in 12th Annual Polychar World Forum on Advanced Materials, 2004.
  30. Leonor, Isabel B.; Balas, F.; Kim, H.-M.; Kokubo, T.; Reis, Rui L.. "Apatite Forming Ability of EVOH Polymeric Biomaterials Modified with Sulfonic Functional Groups". Paper presented in 29th Annual Meeting of the Society For Biomaterials, 2003.
  31. Marques, A. P.; Leonor, Isabel B.; Reis, Rui L.; Hunt, J. A.. "In Vitro Evaluation of the Effect of Starch-based Biodegradable Polymers in Human Leukocytes". Paper presented in 28th Annual Meeting of the Society For Biomaterials, 2002.
  32. Leonor, Isabel B.; Sousa, R. A.; Cunha, A. M.; Zhong, Z.P.; Greenspan, D.; Reis, Rui L.. "New Stiff, Degradable, and Highly Bioactive Bioglass Reinforced Starch based Composite Biomaterials". Paper presented in BioAvila 2000 – 1st Iberian Meeting on Biomaterials and Biosensors, 2000.
Journal article
  1. Vieira, Ana; Rodríguez-Lorenzo, Laura; Leonor, Isabel B.; Reis, Rui L.; Espiña, Begoña; dos Santos, Marília Barreiros. "Innovative Antibacterial, Photocatalytic, Titanium Dioxide Microstructured Surfaces Based on Bacterial Adhesion Enhancement". ACS Applied Bio Materials 6 2 (2023): 754-764. http://dx.doi.org/10.1021/acsabm.2c00956.
    Published • 10.1021/acsabm.2c00956
  2. Albina Cristina Ribeiro Franco; Pirraco, Rogério; Fernandes, Emanuel M.; Rodrigues, Fernando; Leonor, Isabel B.; Kaplan, David L.; Reis, Rui L.. Corresponding author: Reis, Rui L.. "Untangling the biological and inflammatory behavior of silk-like sutures In vivo". Biomaterials 290 (2022): 121829. http://dx.doi.org/10.1016/j.biomaterials.2022.121829.
    Published • 10.1016/j.biomaterials.2022.121829
  3. Lya Piaia; Silva, SS; Gomes, JM; Franco, Albina R.; Fernandes, Emanuel M; Leonor, Isabel B.; Márcio C. Fredel; et al. "Genipin-crosslinked Chitosan/ß-TCP/Silk fibroin scaffolds for Osteochondral Regeneration". ACS Biomaterials Science & Engineering (2022):
    Under revision
  4. Piaia, Lya; Silva, Simone S; Gomes, Joana M; R Franco, Albina; Fernandes, Emanuel M; Lobo, Flávia C M; Rodrigues, Luísa C; et al. Corresponding author: Silva, Simone S. "Chitosan/ß-TCP composites scaffolds coated with silk fibroin: a bone tissue engineering approach". Biomedical Materials 17 1 (2021): 015003. http://dx.doi.org/10.1088/1748-605x/ac355a.
    Published • 10.1088/1748-605x/ac355a
  5. Amann, Elisabeth; Amirall, Amisel; Albina Cristina Ribeiro Franco; Poh, Patrina S. P.; Sola Dueñas, Francisco J.; Fuentes Estévez, Gastón; Leonor, Isabel B.; et al. "A Graded, Porous Composite of Natural Biopolymers and Octacalcium Phosphate Guides Osteochondral Differentiation of Stem Cells". Advanced Healthcare Materials 10 6 (2021): 2001692. http://dx.doi.org/10.1002/adhm.202001692.
    Published • 10.1002/adhm.202001692
  6. Alves, A.C.; Costa, A.I.; Toptan, F.; Alves, J.L.; Leonor, Isabel B.; Ribeiro, E; Reis, Rui L.; Pinto, A.M.P.; Fernandes, J.C.S.. "Effect of bio-functional MAO layers on the electrochemical behaviour of highly porous Ti". Surface and Coatings Technology 386 (2020): 125487. http://dx.doi.org/10.1016/j.surfcoat.2020.125487.
    Published • 10.1016/j.surfcoat.2020.125487
  7. Franco, Albina R.; Palma Kimmerling, Erica; Silva, Carla; Rodrigues, Fernando J.; Leonor, Isabel B.; Reis, Rui L.; Kaplan, David L.. "Silk-Based Antimicrobial Polymers as a New Platform to Design Drug-Free Materials to Impede Microbial Infections". Macromolecular Bioscience 18 12 (2018): 1800262. http://dx.doi.org/10.1002/mabi.201800262.
    Published • 10.1002/mabi.201800262
  8. Costa-Almeida, Raquel; Franco, Albina R.; Pesqueira, Tamagno; Oliveira, Mariana B.; Pedro Babo; Leonor, Isabel B.; Mano, Joao F.; Reis, Rui L.; Manuela E. Gomes. "The effects of platelet lysate patches on the activity of tendon-derived cells". Acta Biomaterialia 68 (2018): 29-40. http://dx.doi.org/10.1016/j.actbio.2018.01.006.
    10.1016/j.actbio.2018.01.006
  9. Pereira, Ana Margarida; Machado, Raul; da Costa, André; Ribeiro, Artur; Bernardo, Telma C.; Collins, Tony; Gomes, Andreia C.; et al. "Corrigendum to "Silk-based biomaterials functionalized with fibronectin type II promotes cell adhesion" [Acta Biomater. 47 (2017) 50-59]". Acta Biomaterialia 49 (2017): 604. http://dx.doi.org/10.1016/j.actbio.2016.11.008.
    10.1016/j.actbio.2016.11.008
  10. Leonor, Isabel B.. "2015 4thTERMIS World CongressBoston, MassachusettsSeptember 8–11, 2015". Tissue Engineering Part A 21 S1 (2015): S-1. http://dx.doi.org/10.1089/ten.tea.2015.5000.abstracts.
    10.1089/ten.tea.2015.5000.abstracts
  11. Susano, M.A.; Leonor, I.B.; Reis, R.L.; Azevedo, H.S.. "Elastic biodegradable starch/ethylene-co-vinyl alcohol fibre-mesh scaffolds for tissue engineering applications". Journal of Applied Polymer Science 131 14 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899432335&partnerID=MN8TOARS.
    10.1002/app.40504
  12. Requicha, J.F.; Moura, T.; Leonor, I.B.; Martins, T.; Muñoz, F.; Reis, R.L.; Gomes, M.E.; Viegas, C.A.. "Evaluation of a starch-based double layer scaffold for bone regeneration in a rat model". Journal of Orthopaedic Research 32 7 (2014): 904-909. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899996303&partnerID=MN8TOARS.
    10.1002/jor.22609
  13. Rodrigues, M.T.; Leonor, I.B.; Gröen, N.; Viegas, C.A.; Dias, I.R.; Caridade, S.G.; Mano, J.F.; Gomes, M.E.; Reis, R.L.. "Bone marrow stromal cells on a three-dimensional bioactive fiber mesh undergo osteogenic differentiation in the absence of osteogenic media supplements: The effect of silanol groups". Acta Biomaterialia (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84902892788&partnerID=MN8TOARS.
    10.1016/j.actbio.2014.05.026
  14. Pires, Ricardo A.; Leonor, Isabel B.; Pashkuleva, Iva; Reis, Rui L.. "Research Highlights: Highlights from the latest articles in nanomedicine". Nanomedicine (London, England) 9 5 (2014): 573-6.
    10.2217/nnm.14.29
  15. Leonor, Isabel B.. "Development of new chimeric proteins for tissue engineering". Journal of Tissue Engineering and Regenerative Medicine 7 (2013): 6-52. http://dx.doi.org/10.1002/term.1822.
    10.1002/term.1822
  16. Requicha, J.F.; Viegas, C.A.; Hede, S.; Leonor, I.B.; Reis, R.L.; Gomes, M.E.. "Design and characterization of a biodegradable double-layer scaffold aimed at periodontal tissue-engineering applications". Journal of Tissue Engineering and Regenerative Medicine (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84883230772&partnerID=MN8TOARS.
    10.1002/term.1816
  17. Gomes, S.; Gallego-Llamas, J.; Leonor, I.B.; Mano, J.F.; Reis, R.L.; Kaplan, D.L.. "In Vivo Biological Responses to Silk Proteins Functionalized with Bone Sialoprotein". Macromolecular Bioscience 13 4 (2013): 444-454. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876464459&partnerID=MN8TOARS.
    10.1002/mabi.201200372
  18. Carvalho, P.P.; Leonor, I.B.; Smith, B.J.; Dias, I.R.; Reis, R.L.; Gimble, J.M.; Gomes, M.E.; et al. "Undifferentiated human adipose-derived stromal/stem cells loaded onto wet-spun starch-polycaprolactone scaffolds enhance bone regeneration: Nude mice calvarial defect in vivo study". Journal of Biomedical Materials Research - Part A (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84885350787&partnerID=MN8TOARS.
    10.1002/jbm.a.34983
  19. Rodrigues, A.I.; Gomes, M.E.; Leonor, I.B.; Reis, R.L.. "Bioactive starch-based scaffolds and human adipose stem cells are a good combination for bone tissue engineering". Acta Biomaterialia 8 10 (2012): 3765-3776. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865448171&partnerID=MN8TOARS.
    10.1016/j.actbio.2012.05.025
  20. Gomes, S.; Gallego-Llamas, J.; Leonor, I.B.; Mano, J.F.; Reis, R.L.; Kaplan, D.L.. "Biological responses to spider silk-antibiotic fusion protein". Journal of Tissue Engineering and Regenerative Medicine 6 5 (2012): 356-368. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859969334&partnerID=MN8TOARS.
    10.1002/term.437
  21. Gomes, S.; Leonor, I.B.; Mano, J.F.; Reis, R.L.; Kaplan, D.L.. "Silk-Based Biomaterials". Biomimetic Approaches for Biomaterials Development (2012): 75-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885782190&partnerID=MN8TOARS.
    10.1002/9783527652273.ch4
  22. Alves, N.M.; Leonor, I.B.; Azevedo, H.S.; Reis, R.L.; Mano, J.F.; Alves, Natália M.; Leonor, Isabel B.; et al. "Surfaces Inducing Biomineralization". Biomimetic Approaches for Biomaterials Development (2012): 333-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885831740&partnerID=MN8TOARS.
    10.1002/9783527652273.ch15
  23. Gomes, S.; Leonor, I.B.; Mano, J.F.; Reis, R.L.; Kaplan, D.L.. "Natural and genetically engineered proteins for tissue engineering". Progress in Polymer Science (Oxford) 37 1 (2012): 1-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-80455174726&partnerID=MN8TOARS.
    10.1016/j.progpolymsci.2011.07.003
  24. Rodrigues, A.I.; Gomes, M.E.; Leonor, I.B.; Reis, R.L.. "In vitro evaluation of osteoconductive starch based scaffolds under dynamic conditions". 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053942947&partnerID=MN8TOARS.
    10.1109/ENBENG.2011.6026083
  25. Gomes, S.C.; Leonor, I.B.; Mano, J.F.; Reis, R.L.; Kaplan, D.L.. "Antimicrobial functionalized genetically engineered spider silk". Biomaterials 32 18 (2011): 4255-4266. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955103835&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2011.02.040
  26. Susano, M.; Frias, A.M.; Leonor, I.B.; Reis, R.L.; Azevedo, H.S.. "Biodegradable fiber-mesh scaffolds with elastic properties and their potential use in tissue engineering". 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84887005139&partnerID=MN8TOARS.
  27. Puppi, D.; Piras, A.M.; Chiellini, F.; Chiellini, E.; Martins, A.; Leonor, I.B.; Neves, N.; Reis, R.. "Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite". Journal of Tissue Engineering and Regenerative Medicine 5 4 (2011): 253-263. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952761764&partnerID=MN8TOARS.
    10.1002/term.310
  28. Leonor, I.B.; Rodrigues, M.T.; Gomes, M.E.; Reis, R.L.. "In situ functionalization of wet-spun fibre meshes for bone tissue engineering". Journal of Tissue Engineering and Regenerative Medicine 5 2 (2011): 104-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-79251485660&partnerID=MN8TOARS.
    10.1002/term.294
  29. Gomes, S.; Leonor, I.B.; Mano, J.F.; Reis, R.L.; Kaplan, D.L.. "Spider silk-bone sialoprotein fusion proteins for bone tissue engineering". Soft Matter 7 10 (2011): 4964-4973. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955655081&partnerID=MN8TOARS.
    10.1039/c1sm05024a
  30. Gomes, S.; Numata, K.; Leonor, I.B.; Mano, J.F.; Reis, R.L.; Kaplan, D.L.. "AFM study of morphology and mechanical properties of a chimeric spider silk and bone sialoprotein protein for bone regeneration". Biomacromolecules 12 5 (2011): 1675-1685. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955802511&partnerID=MN8TOARS.
    10.1021/bm2000605
  31. Alves, N.M.; Leonor, I.B.; Azevedo, H.S.; Reis, R.L.; Mano, J.F.. "Designing biomaterials based on biomineralization of bone". Journal of Materials Chemistry 20 15 (2010): 2911-2921. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950249524&partnerID=MN8TOARS.
    10.1039/b910960a
  32. Leonor, I.B.; Alves, C.M.; Azevedo, H.S.; Reis, R.L.. "Effects of protein incorporation on calcium phosphate coating". Materials Science and Engineering C 29 3 (2009): 913-918. http://www.scopus.com/inward/record.url?eid=2-s2.0-65349101101&partnerID=MN8TOARS.
    10.1016/j.msec.2008.08.003
  33. Martins, A.M.; Pereira, R.C.; Leonor, I.B.; Azevedo, H.S.; Reis, R.L.. "Chitosan scaffolds incorporating lysozyme into CaP coatings produced by a biomimetic route: A novel concept for tissue engineering combining a self-regulated degradation system with in situ pore formation". Acta Biomaterialia 5 9 (2009): 3328-3336. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349873399&partnerID=MN8TOARS.
    10.1016/j.actbio.2009.05.027
  34. Oliveira, J.M.; Costa, S.A.; Leonor, I.B.; Malafaya, P.B.; Mano, J.F.; Reis, R.L.. "Novel hydroxyapatite/carboxymethylchitosan composite scaffolds prepared through an innovative "autocatalytic" electroless coprecipitation route". Journal of Biomedical Materials Research - Part A 88 2 (2009): 470-480. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149391327&partnerID=MN8TOARS.
    10.1002/jbm.a.31817
  35. Gomes, Silvia; Boulon, Marie Emmanuelle; Oliveira, A.L.; Leonor, Isabel B.; Mano, João F.; Reis, Rui L.. "Mineralization of Chitosan Membrane Using a Double Diffusion System for Bone Related Applications". Materials Science Forum 587-588 (2008): 77-81. http://dx.doi.org/10.4028/www.scientific.net/msf.587-588.77.
    10.4028/www.scientific.net/msf.587-588.77
  36. Gomes, S.; Boulon, M.-E.; Oliveira, A.L.; Leonor, I.B.; Mano, J.F.; Reis, R.L.. "Mineralization of chitosan membrane using a double diffusion system for bone related applications". Materials Science Forum 587-588 (2008): 77-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-60349086084&partnerID=MN8TOARS.
  37. Araujo, J.V.; Martins, A.; Leonor, I.B.; Pinho, E.D.; Reis, R.L.; Neves, N.M.. "Surface controlled biomimetic coating of polycaprolactone nanofiber meshes to be used as bone extracellular matrix analogues". Journal of Biomaterials Science, Polymer Edition 19 10 (2008): 1261-1278. http://www.scopus.com/inward/record.url?eid=2-s2.0-61849158807&partnerID=MN8TOARS.
    10.1163/156856208786052335
  38. Leonor, I.B.; Kim, H.-M.; Kawashita, M.; Kokubo, T.; Reis, R.L.. "Novel methodologies for designing bioactive materials for bone applications through by surface functionalization". 8th World Biomaterials Congress 2008 2 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-84869040217&partnerID=MN8TOARS.
  39. Gomes, S.; Rodrigues, M. T.; Leonor, I. B.; Gomes, M. E.; Mano, J. F.; Reis, R. L.. "Conversion of corallina officinalis into calcium phosphates by using hydrothermal treatment and their potential for bone tissue engineering application". Tissue Engineering Part A 14 5 (2008): P103-P103.
  40. Leonor, Isabel B.. "TERMIS-EU Meeting Abstracts London, UK September 4–7, 2007". Tissue Engineering 13 7 (2007): 1633-1778. http://dx.doi.org/10.1089/ten.2007.1501.
    10.1089/ten.2007.1501
  41. Leonor, I.B.; Kim, H.-M.; Balas, F.; Kawashita, M.; Reis, R.L.; Kokubo, T.; Nakamura, T.. "Surface potential change in bioactive polymer during the process of biomimetic apatite formation in a simulated body fluid". Journal of Materials Chemistry 17 38 (2007): 4057-4063. http://www.scopus.com/inward/record.url?eid=2-s2.0-34748817415&partnerID=MN8TOARS.
    10.1039/b707304f
  42. Leonor, I.B.; Kim, H.-M.; Balas, F.; Kawashita, M.; Reis, R.L.; Kokubo, T.; Nakamura, T.. "Alkaline treatments to render starch-based biodegradable polymers self-mineralizable". Journal of Tissue Engineering and Regenerative Medicine 1 6 (2007): 425-435. http://www.scopus.com/inward/record.url?eid=2-s2.0-45849108383&partnerID=MN8TOARS.
    10.1002/term.54
  43. Leonor, I.B.; Kim, H.-M.; Balas, F.; Kawashita, M.; Reis, R.L.; Kokubo, T.; Nakamura, T.. "Functionalization of different polymers with sulfonic groups as a way to coat them with a biomimetic apatite layer". Journal of Materials Science: Materials in Medicine 18 10 (2007): 1923-1930. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548741299&partnerID=MN8TOARS.
    10.1007/s10856-007-3106-6
  44. Oliveira, J.M.; Grech, J.M.R.; Leonor, I.B.; Mano, J.F.; Reis, R.L.. "Calcium-phosphate derived from mineralized algae for bone tissue engineering applications". Materials Letters 61 16 (2007): 3495-3499. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248401214&partnerID=MN8TOARS.
    10.1016/j.matlet.2006.11.099
  45. Martins, A. M.; Salgado, A. J.; Azevedo, H. S.; Leonor, I. B.; Reis, R. L.. "Lysozyme incorporation in biomimetic coated chitosan scaffolds: Development and behaviour in contact with osteoblastic-like cells". Tissue Engineering 12 4 (2006): 103-103.
  46. Azevedo, H.S.; Leonor, I.B.; Alves, C.M.; Reis, R.L.. "Incorporation of proteins and enzymes at different stages of the preparation of calcium phosphate coatings on a degradable substrate by a biomimetic methodology". Materials Science and Engineering C 25 2 (2005): 169-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-17844372469&partnerID=MN8TOARS.
    10.1016/j.msec.2005.01.007
  47. Costa, S.A.; Oliveira, J.M.; Leonor, I.B.; Reis, R.L.. "Carboxymethylchitosan/calcium phosphate hybrid materials prepared by an innovative auto-catalytic co-precipitation method". Key Engineering Materials 284-286 (2005): 701-704. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249037052&partnerID=MN8TOARS.
  48. Azevedo, H.S.; Leonor, I.B.; Alves, C.M.; Goldsmith, R.J.; Reis, R.L.. "Influence of protein incorporation in the nucleation and growth of biomimetic calcium phosphate coatings". Transactions - 7th World Biomaterials Congress (2004): http://www.scopus.com/inward/record.url?eid=2-s2.0-13844255636&partnerID=MN8TOARS.
  49. Leonor, I.B.; Malafaya, P.B.; Baran, E.T.; Kawashita, M.; Reis, R.L.; Kokubo, T.; Nakamura, T.. "Growth of a bonelike apatite layer on chitosan microparticles after a calcium silicate treatment". Transactions - 7th World Biomaterials Congress 4 5 (2004): 1349-1359. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844276247&partnerID=MN8TOARS.
    10.1016/j.actbio.2008.03.003
  50. Leonor, I.B.; Reis, R.L.. "An innovative auto-catalytic deposition route to produce calcium-phosphate coatings on polymeric biomaterials". Journal of Materials Science: Materials in Medicine 14 5 (2003): 435-441. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038356739&partnerID=MN8TOARS.
    10.1023/A:1023214918592
  51. Oliveira, A.L.; Leonor, I.B.; Malafaya, P.B.; Alves, C.M.; Azevedo, H.S.; Reis, R.L.. "Tailoring the bioactivity of natural origin inorganic - Polymeric based systems". Key Engineering Materials 240-242 (2003): 111-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-18844465713&partnerID=MN8TOARS.
  52. Leonor, I.B.; Ito, A.; Onuma, K.; Kanzaki, N.; Reis, R.L.. "In vitro bioactivity of starch thermoplastic/hydroxyapatite composite biomaterials: An in situ study using atomic force microscopy". Biomaterials 24 4 (2003): 579-585. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037290224&partnerID=MN8TOARS.
    10.1016/S0142-9612(02)00371-X
  53. Leonor, I.B.; Ito, A.; Onuma, K.; Kanzaki, N.; Zhong, Z.; Greenspan, D.; Reis, R.L.. "In-situ AFM study of the mechanisms involved on calcium-phosphate film formation on partially crystallized Bioglass® and on hydroxylapatite immersed in a simulated body fluid". Key Engineering Materials 218-220 (2002): 291-294. http://www.scopus.com/inward/record.url?eid=2-s2.0-17744415658&partnerID=MN8TOARS.
  54. Leonor, I.B.; Ito, A.; Onuma, K.; Kanzaki, N.; Reis, R.L.. "Atomic force microscopy as a tool to study in-situ the in-vitro bioactivity of starch thermoplastic/hydroxylapatite biomaterials". Key Engineering Materials 218-220 (2002): 55-60. http://www.scopus.com/inward/record.url?eid=2-s2.0-8544276542&partnerID=MN8TOARS.
  55. Leonor, I.B.; Sousa, R.A.; Cunha, A.M.; Reis, R.L.; Zhong, Z.P.; Greenspan, D.. "Novel starch thermoplastic/Bioglass® composites: Mechanical properties, degradation behavior and in-vitro bioactivity". Journal of Materials Science: Materials in Medicine 13 10 (2002): 939-945. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036796464&partnerID=MN8TOARS.
    10.1023/A:1019800411229
  56. Leonor, I.B.; Ito, A.; Onuma, K.; Kanzaki, N.; Zhong, Z.P.; Greenspan, D.; Reis, R.L.. "In situ study of partially crystallized Bioglass® and hydroxylapatite in vitro bioactivity using atomic force microscopy". Journal of Biomedical Materials Research 62 1 (2002): 82-88. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036325762&partnerID=MN8TOARS.
    10.1002/jbm.10289
  57. Leonor, I.B.; Sousa, R.A.; Cunha, A.M.; Zhong, Z.P.; Greenspan, D.; Reis, R.L.. "Development of highly bioactive and mechanically strong starch thermoplastic/bioglass composite biomaterials". Key Engineering Materials 192-195 (2001): 705-708. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243229866&partnerID=MN8TOARS.
  58. Leonor, I.B.; Reis, R.L.. "Novel auto-catalytic deposition methodology to produce calcium-phosphate coatings on polymeric biomaterials". Key Engineering Materials 192-195 (2001): 83-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-18144449799&partnerID=MN8TOARS.
Newspaper article
  1. Leonor, Isabel B.. "Spider silk stitches up antibacterial coatings", Materials Today , 2020, https://www.sciencedirect.com/science/article/pii/S136970211930882X?dgcid=raven_sd_via_email.
Thesis / Dissertation
  1. Leonor, Isabel B.. "New biomimetic acellular routes for pre-calcification of implant materials, carrier particles and porous scaffolds". PhD, Universidade do Minho Escola de Engenharia, 2008. http://repositorium.sdum.uminho.pt/handle/1822/7519.

Other

Other output
  1. Antimicrobial coating of spider silk to prevent bacterial attachment on silk surgical sutures. Microbial infections from post-surgery or other medical-related procedure is a serious health problem. Nowadays, the research is focused on the development of new drug-free materials with antibacterial properties to prevent or minimize the risk of infections. Spider silk is known for its unique biomechanical properties allied with biocompatibility. Recombinant DNA technology allows to bioengineeri. 2019. Franco, Albina R.; Fernandes, Emanuel M.; Rodrigues, Márcia T.; Rodrigues, Fernando J.; Gomes, Manuela E.; Leonor, Isabel B.; Kaplan, David L.; Reis, R. L.. http://hdl.handle.net/1822/62294.
    10.1016/j.actbio.2019.09.004
  2. A Tissue Engineering Approach for Periodontal Regeneration Based on a Biodegradable Double-Layer Scaffold and Adipose-Derived Stem Cells. 2014. Requicha, João F.; Viegas, Carlos A.; Muñoz, Fernando; Azevedo, Jorge M.; Leonor, Isabel B.; Reis, Rui L.; Gomes, Manuela E.. http://hdl.handle.net/10348/4612.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2014/05/07 Spider Silk based Biomaterials” MIT-PORTUGAL BioNanotechnology and Biomaterials MIT-PORTUGAL BioNanotechnology and Biomaterials
3B’s Research Group – AvePark, Taipas, Guimara~es, Portugal (Guimarães, Portugal)
2013/11/04 Beauty and Secrets of Spider Silk: genetically engineered sutures for preventing surgical site infections Ciência Falada | Science and Society Events
Life and Health Sciences Research Institute, School of Health Sciences, University of Minho (BRAGA, Portugal)
2009/10/30 Why biomineralization is important in tissue engineering? 3B’s Short Workshop on “Natural-base polymers for biomedical applications”
3B’s Research Group – AvePark, Taipas, Guimara~es, Portugal (Guimarães, Portugal)
2005/11 Funcionalização de Superfícies e Bioactividade Jornadas de Engenharia de Materiais (LEMAT), Universidade do Minho
Universidade do Minho, Escola de Engenharia (Guimarães, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2019/02/01 - Current Unravelling the potential of platelet-rich plasma as a new platform for developing materials with antimicrobial properties (Junior Researcher - CTTI- 57/18-I3BS(5) Profile 01)
Supervisor of Albina Cristina Ribeiro Franco
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2021/08/30 - 2023/04/30 Análise estrutural e elementar do dente do gato (Felis catus) com recurso a técnicas de microscopia avançada
Co-supervisor of Iulian Sclifos
Medicina Veterinária (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2015/10/01 - 2019/01/31 Unravelling the potential of platelet-rich plasma as a new platform for developing materials with antimicrobial properties” (Post-Doc researcher student financed by Portuguese Foundation for Science and Technology (FCT) - SFRH/BPD/100760/2014) in collaboration with Prof. David Kaplan, Tufts University, USA
Co-supervisor of Albina Cristina Ribeiro Franco
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2013/10 - 2016/05 Fabrication of Bioactive Periosteum Membranes for Bone Regeneration Using Innovative Self-assembling and Nanofabrication Approaches (Researcher under the R&D Project OSTEOSYNTHESIS - PTDC/CTM-BIO/0814/2012)
Co-supervisor of Sofia Ribeiro
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2014/12 - 2015/10 Development of antibacterial surfaces bioinspired on the micro/nanotopography of natural surfaces (Post-doc under European Project POLARIS - REGPOT-CT2012-316331)
Supervisor of Marilia Santos
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2014/04 - 2015/09 Nanobiomaterials for preventing hospital acquired infections" (Post-doc under the R&D Project POLARIS - REGPOT-CT2012-316331, 2012-2015)
Co-supervisor
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2013/11 - 2015/09 Development of sutures with antimicrobial properties for preventing surgical site infections" (Post-doc under the R&D Project ACROSS - PTDC/BBB-BIO/0827/2012)
Supervisor
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2014/03 - 2014/10 Exploring the potential of morphological techniques in the characterization of extracellular matrix formation (Post-doc under the R&D Project RL2-SCN - NORTE-01-0124-FEDER-000018, 2013-2015)
Co-supervisor of Patricia Martins
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2010 - 2014 Instructive polymer scaffolds: a bottom-up approach for engineering vascularized bone graft (financed by Portuguese Foundation for Science and Technology (FCT) - SFRH/BD/69962/2010) in collaboration with Prof. Clemens A. Van Blitterswijk, University of Twente, The Netherlands; Supervised by Rui L. Reis and by Isabel B. Leonor
Co-supervisor of Ana Isabel Gomes Leitão Rodrigues
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2012/07/16 - 2013/10/11 Development of new chimeric proteins to be used in the fabrication of a novel biomaterial for bone regeneration application (Researcher under the R&D Project Chimera - PTDC/EBB-EBI/109093/2008)
Co-supervisor of Ana Margarida Pereira
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2012/07/16 - 2013/10/11 Development of new chimeric proteins to be used in the fabrication of a novel biomaterial for bone regeneration application (Researcher under the R&D Project Chimera - PTDC/EBB-EBI/109093/2008).
Co-supervisor of Telma Sofia Correia Bernardo
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2008 - 2011 Combination of Osteogenic Factors with Biomimetic Methodologies for Bone Tissue Engineering Applications (Researcher under the R&D Project MIMESIS - PTDC/CTM/67560/2006)
Co-supervisor of Maria Susano
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2007 - 2011 Genetically engineered new spider silk chimeras for bone regeneration” (financed by Portuguese Foundation for Science and Technology (FCT) - SFRH/BD/28603/2006) in collaboration with Prof. David Kaplan, Tufts University); Supervised by Rui L. Reis, João Mano and by Isabel B. Leonor
Co-supervisor of Sílvia Cristina Gomes Pereira
Programa Doutoral Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais (PhD)
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2009 - 2010 In vitro evaluation of SPCL-Si fibre meshes scaffolds using a flow perfusion bioreactor | Master completed in Biomedical Engineering, U. Minho, December 2010; Supervised by Rui L. Reis and by Isabel B. Leonor
Co-supervisor of Ana Isabel Gomes Leitão Rodrigues
Ciclo de Estudos Integrados Conducentes ao Grau de Mestre em Engenharia Biomédica (Master)
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2013 - Current Responsible for weekly seminars of 3B´s Research Group (2013)
Seminar (President of the Organising Committee)
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2014/10 - 2014/10 Scientific & Organizing Committee of 2nd POLARIS Workshop on “Top-down fabrication and nano-characterization techniques to develop nanosystems for biomedical applications” (October 2014, Porto, Portugal). (2014/10 - 2014/10)
Workshop (Member of the Scientific Committee)
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2014/10 - 2014/10 Scientific & Organizing Committee of TERM STEM 2014 on “NanoTools for diagnosis and regeneration of tissues with PT | Korea symposium” (October 2014, Porto, Portugal). (2014/10 - 2014/10)
Conference (Member of the Organising Committee)
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2013/10 - 2013/10 Scientific & Organizing Committee of 1st POLARIS Workshop on “Nanosystems for Medicine: fundamentals, synthesis & application” (October 2013, Porto, Portugal). (2013/10 - 2013/10)
Workshop
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2013/10 - 2013/10 Scientific & Organizing Committee of TERM STEM 2013 on “Nanotechnology as a Tool for improving Tissue Engineering and Regenerative Medicine” (October 2013, Porto, Portugal). (2013/10 - 2013/10)
Conference (Member of the Scientific Committee)
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2012/10 - 2012/10 Scientific & Organizing Committee of TERM STEM on “Stem Cells and the Future of Regenerative Medicine: From Basic Research to Translational Aspects and Upcoming Therapies” (October 2012, Vila Flor Cultural Centre, Guimarães, Portugal). (2012/10 - 2012/10)
Conference (Member of the Scientific Committee)
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2011/10 - 2011/10 Organization Committee of 4th Joint ESAO-IFAO Congress (October 2011, in Porto, Portugal). (2011/10 - 2011/10)
Conference (Member of the Organising Committee)
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2009/09 - 2009/09 Scientific & Organizing Committee (co-chair) of 3rd Marie Curie Cutting Edge InVENTS Practical Training Course on “Fabrication and Characterisation of Tissue Engineering Scaffolds” (September 2009, 3B’s Research Group facilities, AvePark, Guimarães, Portugal). (2009/09 - 2009/09)
Other (Member of the Scientific Committee)
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2008/10 - 2008/10 Scientific & Organizing Committee of 6th Marie Curie Cutting Edge InVENTS Conference on “Stem cells: from the Petri dish to the clinical application” (October 2008, Alvor, Portugal). (2008/10 - 2008/10)
Conference (Member of the Organising Committee)
Universidade do Minho Escola de Engenharia, Portugal
2008/06 - 2008/06 Organization Committee of 2008 TERMIS-EU Annual Meeting (June 2008, Porto, Portugal) (2008/06 - 2008/06)
Congress (Member of the Organising Committee)
Universidade do Minho Escola de Engenharia, Portugal
2008/04 - 2008/04 Scientific & Organizing Committee of 5th Marie Curie Cutting Edge InVENTS Conference on “Synthesis and applications of self-assembling materials at nano-scale” (April 2008, Funchal, Madeira, Portugal). (2008/04 - 2008/04)
Other (Member of the Scientific Committee)
Universidade do Minho Escola de Engenharia, Portugal
2007/06 - 2007/06 Scientific & Organizing Committee of 3rd Marie Curie Cutting Edge InVENTS Conference on “Biomineralisation of polymeric materials, bioactive biomaterials and biomimetic methodologies” (June 2007, Funchal, Madeira, Portugal). (2007/06 - 2007/06)
Conference (Member of the Scientific Committee)
Universidade do Minho Escola de Engenharia, Portugal
2006/10 - 2006/11 Scientific & Organizing Committee of ESF/EMBO Symposium on “Stem Cells in Tissue engineering isolation, culture, characterisation and applications” (October -November 2006, Sant Feliu de Guixols, Spain. (2006/10 - 2006/11)
Symposium (Member of the Organising Committee)
Universidade do Minho Escola de Engenharia, Portugal
2006/10 - 2006/10 Scientific & Organizing Committee of 2nd Marie Curie Cutting Edge InVENTS Conference on “Recent Advances on Polymeric Based Systems for Controlled Delivery of Bioactive Agents: Applications in Tissue Engineering” (October 2006, Alvor, Portugal). (2006/10 - 2006/10)
Other (Member of the Scientific Committee)
Universidade do Minho Escola de Engenharia, Portugal
2006/06 - 2006/06 Scientific & Organizing Committee of 1st Marie Curie Cutting Edge Conference on “New Developments on Polymers for Tissue Engineering, Replacement and Regeneration” (June 2006, Funchal, Madeira, Portugal). (2006/06 - 2006/06)
Conference (Member of the Scientific Committee)
Universidade do Minho Escola de Engenharia, Portugal
2001/10 - 2001/10 Organizing Committee of NATO-ASI course on “Polymer based Systems on Tissue Engineering, Replacement and Regeneration” (October 2001, Alvor, Portugal). (2001 - 2001)
Conference (Member of the Organising Committee)
Universidade do Minho Escola de Engenharia, Portugal
2001/10 - 2001/10 Scientific & Organizing Committee of NATO-ASI course on “Learning from Nature How to Design New Implantable Biomaterials: From Biomineralization Fundamentals to Biomimetic Materials and Processing Routes” (October 2003, Alvor, Portugal). (2001/10 - 2001/10)
Conference (Member of the Organising Committee)
Universidade do Minho Escola de Engenharia, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2022/10/12 - 2022/10/12 Participation in the CIÊNCIAVIATE Platform
Meeting
Cienvia ID
Fundação para a Ciência e a Tecnologia, Portugal
2022/03/13 - 2022/03/16 EMBL Conference, 6th Joint Meeting Workshop and Virtual Symposium on ¿From 3D Light to 3D Electron Microscopy¿
Symposium
Correlative Microscopy Symposium
EMBL Heidelberg, Germany

VIB UGent Centrum voor Medische Biotechnologie, Belgium

The Francis Crick Institute, United Kingdom
2021/09/29 - 2021/10/01 Virtual Conference Microscopy at the Frontiers of Science 2021
Conference
Virtual Conference Microscopy at the Frontiers of Science 2021
International Iberian Nanotechnology Laboratory, Portugal
2020/10/08 - 2020/10/08 Correlative microscopy: challenges and solutions for data acquisition and analysis
Workshop
Oxford Instruments
2020/07/20 - 2020/07/20 AFMBioMed 2020 Summer School
Meeting
Bruker
Aix-Marseille Université, France
2020/07/14 - 2020/07/14 ZEISS MultiSEM for Large-Area Imaging - Pushing the Throughput of Scanning Electron Microscopy
Workshop
Zeiss | CNR IMM – Institute of Microelectronics and Microsystems Section of Bologna
2020/07/07 - 2020/07/07 ZEISS Virtual FIBSEM User Meeting Italy 2020: Nanofabrication Day
Workshop
Zeiss | CNR IMM – Institute of Microelectronics and Microsystems Section of Bologna
2020/06/30 - 2020/06/30 ZEISS Virtual FIBSEM User Meeting Italy 2020: 3D Electron and Ion Microscopy Day
Workshop
Zeiss | CNR IMM – Institute of Microelectronics and Microsystems Section of Bologna
2020 - 2020 Participation in the presentation of CIÊNCIAVIATE Platform
Meeting
CIÊNCIAVITAE (https://cienciavitae.pt/?lang=en)
Fundação para a Ciência e a Tecnologia, Portugal
2016/04 - 2016/04 Bruker Workshop & Training Day at the “AFM BioMed Conference”, April 2016, Porto, Portugal.
Conference
AFM BioMed | Conference
Instituto Nacional de Engenharia Biomédica, Portugal
2013/07/18 - 2013/07/19 Training on Inductively Coupled Plasma Spectrometer, ControLab, Dias de Sousa Group.
Other
Training on Inductively Coupled Plasma Spectrometer
2013/05 - 2013/05 Participation in 2nd European FluidFM Workshop, Nanosurf AG, Liestal, Switzerland.
Workshop
European FluidFM Workshop
Nanosurf AG, Switzerland
2010/04 - 2010/04 2010 Materials Research Society (MRS) Spring Meeting, April 2010, San Francisco, CA, USA,
Conference
Materials Research Society (MRS) Spring Meeting
Materials Research Society, United States
2009/10 - 2009/10 3B’s Workshop on “Natural-base polymers for biomedical applications”, 29th to 30th October, 3B’s Research Group – AvePark, Caldas das Taipas, Guimarães, Portugal.
Workshop
3B’s Workshop
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2006 - 2009 Participation in several meetings of the EU funded project “InVENTS – An Integrated Series of Events for High-Level Training on Biomaterials, Tissue Engineering, Controlled Drug Delivery and Related Emerging Fields”, Marie Curie Actions (MCA), Series of Events (SCF) (MSCF-CT-2005-029793).
Conference
InVENTS – An Integrated Series of Events for High-Level Training on Biomaterials, Tissue Engineering, Controlled Drug Delivery and Related Emerging Fields
3B´s Research Group - I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics - University of Minho , Portugal
2008/05 - 2008/06 Co-chair of the Session entitled “Chemical modification of biomaterial surfaces”, 8th World Biomaterials Congress (May-June 2008, Amsterdam, The Netherlands).
Congress
8th World Biomaterials Congress
2007/07 - 2007/07 Crioestaminal Workshop on “Stem cells in Health Biotechnology", Cantanhede, Portugal.
Workshop
CRIOESTAMINAL Workshop
2006/10/17 - 2006/10/20 EXPERTISSUES Training Course on “Cells-Biomaterials Interactions”, Institute of macromolecular chemistry, Academy of Sciences of Czech Republic, Prague, Czech Republic.
Other
EXPERTISSUES Training Course
Ústav makromolekulární chemie Akademie ved Ceské republiky, Czech Republic
2004/06/20 - 2004/06/27 Advanced Practical Course on “The Design and Building of Quartz Crystal Microbalance (QCM) Biosensors”, FEBS (The Federation of European Biochemical Societies), Hacettepe University, Ankara, Turkey.
Other
The Design and Building of Quartz Crystal Microbalance (QCM) Biosensors
Hacettepe Üniversitesi, Turkey

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2022/12/01 - 2023/01/31 Expert Evaluator for HORIZON-MSCA-2022-DN (2022-2023).
Evaluator
European Commission Marie Sklodowska-Curie Actions, Belgium European Commission Marie Sklodowska-Curie Actions
2019 - 2020 Expert Evaluator for Career-FIT PLUS proposals under EU-Enterprise Ireland programme (2019-2020)
Evaluator
Enterprise Ireland, Ireland
2018 - 2018 Expert Evaluator for the European Commission of research proposals in the HORIZON 2020 FET Open (2018) European Commission, Belgium
2008 - 2013 Expert Evaluator for the European Commission of research proposals in the frame of the Seventh Framework Programme (FP7) (2008-2010; 2012-2013) FP7 Nanosciences Nanotechnologies Materials and New Production Technologies, Belgium

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2020/01/11 Over 4 million EU patients acquire infections while in hospital, with over a fifth arising from surgery. Coating silk sutures with proteins derived from spider silk could alleviate the problem of post-surgical infection, according to a team of scientists from Portugal and the USA [Franco et al., Acta Biomaterialia (2019), https://doi.org/10.1016/j.actbio.2019.09.004]. Materials Today

Other jury / evaluation

Activity description Institution / Organization
2003/01 - 2020/12 - Journal of Tissue Engineering and Regenerative Medicine, Journal of Biomedical Materials Research: part A, Journal of Biomedical Materials Research: part B – Applied Biomaterials, Journal of Biomaterials Applications (Wiley Interscience); - Biomacromolecules, Langmuir (American Chemical Society); - Acta Biomaterialia, Journal of Non-Crystalline Solids, Surface and Coatings Technology (Elsevier); - New Journal of Chemistry (Royal Society of Chemistry)

Scientific expedition

Activity description Institution / Organization
2000/04 - 2000/10 Certificate of Competency in Operating an Atomic Force Microscope for more than 430 hours, and acquired the following techniques: 1- all the preparation procedures before observation; 2- contact mode observation in the air using a Si3N4 cantilever; 3- contact mode observation in aqueous solutions using a Si3N4 cantilever; National Institute for Advanced Industrial Science and Technology, Japan
Distinctions

Award

2008 Awarded for the Best PhD Thesis
Universidade do Minho Escola de Engenharia, Portugal
2007 Short-term scholarship for participating in the 21st Meeting of the European Society For Biomaterials in 2007, Brighton, UK.
Fundação Calouste Gulbenkian, Portugal

Other distinction

2004 Best Oral Presentation
2004 Short-term scholarship for participating in the 17th International Symposium on Ceramics in Medicine (ISCM) in New Orleans, Louisiana, USA.
Fundação Calouste Gulbenkian, Portugal
2003 Kluwer Prize for best oral presentation
2001 Short-term scholarship for participating in the 16th Meeting of the European Society of Biomaterials in 2001 in London, United Kingdom
Fundação Calouste Gulbenkian, Portugal