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Identification

Personal identification

Full name
Céline Saraiva Gonçalves

Citation names

  • Gonçalves, Céline S.

Author identifiers

Ciência ID
9517-71D4-E9A6
ORCID iD
0000-0002-3713-119X
Google Scholar ID
EtL_1EwAAAAJ
Researcher Id
T-5289-2018
Scopus Author Id
56572179800

Addresses

  • Instituto de Investigação em Ciências da Vida e Saúde (ICVS), Escola de Medicina – Universidade do Minho, Campus de Gualtar, 4710-057 , Gualtar, Braga, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Medical and Health Sciences - Basic Medicine
  • Medical and Health Sciences - Health Sciences
  • Natural sciences - Biological Sciences
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
French (Mother tongue)
English Advanced (C1) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2014 - 2018/12/17
Concluded
 PhD in Health Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
"Deciphering key roles of WNT6 in glioblastoma: mechanistic, functional, and clinical insights" (THESIS/DISSERTATION)
 Very Good - Highest Grade
2011 - 2013
Concluded
 Master in Health Sciences (Mestrado)
Universidade do Minho Escola de Ciências da Saúde, Portugal
"Regulation of WNT Signaling by HOXA9 in Glioblastoma: Mechanistic, Prognostic and Therapeutic Insights" (THESIS/DISSERTATION)
 18
2008 - 2011
Concluded
 Biochemistry (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"The Transcriptome of the Oncogenic HOXA9 Homeoprotein in Human Glioblastoma: Functional and Clinical Relevance" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2022/01/06 - Current Contracted Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/01/01 - 2021/11/26 Postdoc (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014/09/01 - 2018/12/17 Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014/01/01 - 2014/08/31 Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009/10/01 - 2010/10/01 Research Trainee (Research) Universidade do Minho Centro de Química, Portugal
Projects

Grant

Designation Funders
2014/09/01 - 2018/08/31 Deciphering key roles of WNT6 in glioblastoma: mechanistic, functional, and clinical insights
SFRH/BD/92786/2013
PhD Student Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
Fundação para a Ciência e a Tecnologia
2014/01/01 - 2014/08/31 The Transcriptome of the Oncogenic HOXA9 Homeoprotein in Human Glioblastoma: Functional and Clinical Relevance
PTDC/SAU-GMG/113795/2009
Research Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/10/01 - 2010/10/01 Preparation of precursor for enantioselective synthesis of azasugar by Diels-Alder methodology
UMINHO/BII/270/2009
Integration into Research Grant Fellow
Universidade do Minho Centro de Química, Portugal
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2022/07/07 - 2028/07/06 Investigating new strategies for brain tumors theranostics: an integrated view around WNT6 oncogene
2021.02600.CEECIND/CP1664/CT0015
10.54499/2021.02600.CEECIND/CP1664/CT0015
Principal investigator
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2026/02/28 Exploiting the immune landscape of HOXA9/WNT6-driven glioblastoma: opportunities for novel precision therapies
2022.04859.PTDC
10.54499/2022.04859.PTDC
Researcher
Universidade do Minho, Portugal

Instituto de Investigaciones Biomédicas Sols-Morreale, Spain

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/06 - 2024/09/05 Tracking brain tumors through their exosomes: a WNT6-driven approach
2022.05143.PTDC
10.54499/2022.05143.PTDC
Principal investigator
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023 - 2024 WNTrack: Tracking brain tumors through their exosomes: a proof-of-concept
WNTrack
Principal investigator
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 2CA-Braga
Ongoing
2021 - 2024 MONET: Multi-Omic NETworks in gliomas
PTDC/CCI-BIO/4180/2020
Researcher
Universidade Nova de Lisboa, Portugal

Universidade Nova Centro de Matemática e Aplicações, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/12 - 2023/06 LiquidGBM - A novel liquid biopsy tool for glioblastoma
LiquidGBM
Principal investigator
TecMinho Associação Universidade-Empresa para o Desenvolvimento
Concluded
2019/09/01 - 2021/11/26 Local specific treatment of triple-negative-breast cancer through externally triggered target-less drug carriers
UMINHO/BPD/27/2019
Post-doc Fellow
Laboratório Associado ICVS 3B's, Portugal

International Iberian Nanotechnology Laboratory, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017/07/01 - 2017/12/31 Validation of a Cancer Immunotherapy Strategy Applying Artificial Peptides Designed by HABIT
iProof20-HABIT
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 TecMinho Associação Universidade-Empresa para o Desenvolvimento
Concluded

Other

Designation Funders
2016 - 2020 FROnTHERA - Frontiers of technology for theranostics of cancer, metabolic and neurodegenerative diseases
NORTE-01-0145-FEDER-000023
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
Comissao de Coordenacao e Desenvolvimento Regional do Norte
Ongoing
2016 - 2020 New avenues for the development of personalized medical interventions for neurological, oncologic and surgical disorders - PersonalizedNOS
NORTE-01-0145-FEDER-000013
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
Comissao de Coordenacao e Desenvolvimento Regional do Norte
Ongoing
Outputs

Publications

Book chapter
  1. Gonçalves, Céline S.; Lourenço, Tatiana; Xavier-Magalhães, Ana; Pojo, Marta; Costa, Bruno M.. "Mechanisms of Aggressiveness in Glioblastoma: Prognostic and Potential Therapeutic Insights". In Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications, edited by Terry Lichtor. InTech, 2013.
    10.5772/52361
  2. Gonçalves, Céline S.; Xavier-Magalhães, Ana; Costa, Bruno M.. "Molecular Pathology of Glioma". In Molecular Determinants of Glioma Risk and Patient Prognosis, 31-55. 2012.
    ISBN: 978-3-8573-3502-3
Conference abstract
  1. Gonçalves, Céline S.; Vieira de Castro, J; Pojo, M; Martins, EP; Taipa, R; Pinto, AA; Faria, CC; et al. "PO-473 Wnt6 expression in glioblastoma: mechanistic, functional and clinical implications". Paper presented in 25th Biennial Congress of the European Association for Cancer Research (EACR), Amsterdam, 2018.
    10.1136/esmoopen-2018-eacr25.978
  2. Martins, EP; Pojo, M; Gonçalves, Céline S.; Carvalho, R; Ribeiro, AS; Pardal, F; Pinto, AA; et al. "PO-105 Cdh3/p-cadherin as a novel biomarker in glioblastoma: functional and prognostic insights". Paper presented in 25th Biennial Congress of the European Association for Cancer Research (EACR), Amsterdam, 2018.
    10.1136/esmoopen-2018-eacr25.146
  3. Gonçalves, Céline S.; Pojo, Marta; Xavier-Magalhães, Ana; Vieira de Castro, Joana; Pinto, Afonso A.; Taipa, Ricardo; Pardal, Fernando; et al. "Regulation of Wnt6 by Hoxa9 in Glioblastoma: Functional and Clinical Relevance". Paper presented in 24th Biennial Congress of the European Association for Cancer Research (EACR), Manchester, 2016.
    10.1016/S0959-8049(16)61151-6
  4. Gonçalves, Céline S.; Pojo, Marta; Costa, Bruno M.. "Regulation of WNT signaling by HOXA9 in glioblastoma: mechanistic, prognostic and therapeutic insights". Paper presented in SPSAS – Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment, São Paulo, 2013.
  5. Gonçalves, Céline S.; Xavier-Magalhães, Ana; Lourenço, Tatiana; Pojo, Marta; Rocha, Miguel; Lopes, Maria C.; Crespo, Inês; et al. "Long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is associated with poor prognosis in glioblastoma". Paper presented in SPSAS – Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment, São Paulo, 2013.
  6. Gonçalves, Céline S.; Xavier-Magalhães, Ana; Rocha, Miguel; Sousa, Nuno; Costa, Bruno M.. "HOXA9 target genes in Glioblastoma: characterization and clinical relevance". Paper presented in 22nd Biennial Congress of the European Association for Cancer Research (EACR-22), Barcelona, 2012.
    10.1016/S0959-8049(12)71224-8
Conference poster
  1. Ferreira, Joana M.; Gonçalves, Céline S.; Martins, Eduarda P.; Costa, Bruno M.. "Deciphering WNT6-driven mechanisms of aggressiveness and resistance to chemotherapy in human glioblastoma". Paper presented in 6th ASPIC International Congress, 2024.
  2. Ferreira, Joana M.; Gonçalves, Céline S.; Martins, Eduarda P.; Costa, Bruno M.. "Deciphering WNT6-driven mechanisms of aggressiveness and resistance to chemotherapy in human glioblastoma". Paper presented in XIV Portuguese Association of Neuro-Oncology National Congress, 2024.
  3. Costa, Marta; Cerqueira, Mónica; Silva, Ana; Pontes, Olívia; Oliveira-Pinto, Sofia; Carvalho, Luísa; Lopes, Diogo; et al. "Chromene-based molecules: privileged scaffold for oncology drug development". Paper presented in III ASPIC-ASEICA International Meeting Abstract Submission, 2023.
  4. Silva, Ana; Félix, Ana; Cerqueira, Mónica; Gonçalves, Céline S.; Longatto, Adhemar; Baltazar, Fátima; Afonso, Julieta. "Effects of lactate transport inhibition by AZD3965 in muscle-invasive urothelial bladder cancer". Paper presented in III ASPIC-ASEICA International Meeting Abstract Submission, 2023.
  5. Lopes, Diogo; Oliveira-Pinto, Sofia; Pontes, Olívia; Sampaio-Marques, Belém; Costa, Marta D.; Carvalho, Luísa; Gonçalves, Céline S.; et al. "Synthesis of chromene[2,3-b]pyridines and characterization of their anticancer potential for the treatment of breast cancer". Paper presented in III ASPIC-ASEICA International Meeting – Cancer Immunology, Tumor Microenvironment and Metastasis, 2023.
  6. Lopes, Diogo; Oliveira-Pinto, Sofia; Pontes, Olívia; Sampaio-Marques, Belém; Costa, Marta D.; Carvalho, Luísa; Gonçalves, Céline S.; et al. "Síntese de cromeno[2,3-b]piridinas e caracterização do seu potencial anticancerígeno para o tratamento do cancro da mama". Paper presented in Encontro Nacional de Jovens Investigadores em Oncologia, 2023.
  7. Ferreira, Joana M.; Gonçalves, Céline S.; Martins, Eduarda P.; Costa, Bruno M.. "Deciphering novel mechanisms of WNT6-driven chemotherapy resistance in human glioblastoma". Paper presented in XIII PortugueseAssociation of Neuro-Oncology National Congress, 2023, 2023.
  8. Martins, Eduarda P.; Gonçalves, Céline S.; Peixoto, Joana; Ferreira, Joana M.; Longatto-Filho, Adhemar; Lima, Jorge; Costa, Pedro M.; Granja, Sara; Costa, Bruno M.. "Unveiling the impact of the oncogenic molecule Cadherin-3 in themetabolism of human glioblastoma". Paper presented in XIII PortugueseAssociation of Neuro-Oncology National Congress, 2023, 2023.
  9. Machado-Sousa, Margarida; Gonçalves, Céline S.; Carvalho-Neves, Andreia; Martins, Eduarda P.; Costa, Liliana; Duarte-Silva, S; Maciel, Patrícia; Costa, Bruno M.. "Role of the ubiquitin hydrolase ATXN3 in glioblastoma: a new tumor suppressor gene?". Paper presented in 5th ASPIC International Congress, 2022.
  10. Peixoto, Joana; Janaki-Raman, Sudha; Schmitz, Werner; Walz, Susanne; Gonçalves, Céline S.; Costa, Bruno M.; Soares, Paula; Schulze, Almut; Lima, Jorge. "Concerted metabolic and transcriptomic rewiring dictates gliioblastoma cells survival and stemness". Paper presented in 5th ASPIC International Congress, 2022.
  11. Costa, Marta; Pontes, Olívia; Duarte-Silva, S; Gonçalves, Céline S.; Bessa, Carlos; Sampaio-Marques, Belém; Bruno M. Costa; et al. "A new lead compound for triple negative breast cancer therapy". Paper presented in XXVI EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2021), 2021.
  12. Pontes, Olívia; Costa, Marta; Sara Duarte-Silva; Gonçalves, Céline S.; Bessa, Carlos; Ludovico, Paula; Maciel, Patrícia; Proenca, Fernanda; Baltazar, Fátima. "A new therapeutic option for triple negative breast cancer". Paper presented in EACR2021, 2021.
  13. Cláudia Martins-Lima; Lobo, João; Constâncio, Vera; Guimarães-Teixeira, Catarina; Miranda-Gonçalves, Vera; Monteiro-Reis, Sara; Lameirinhas, Ana; et al. "EMT impact in bladder cancer progression: understanding the cadherins' role and their regulatory mechanisms". Paper presented in 27th Porto Cancer Meeting, 2021.
  14. Costa, Marta; Pontes, Olívia; Oliveira-Pinto, Sofia; Gonçalves, Céline S.; Duarte-Silva, Sara. "A new lead compound for triple negative breast cancer therapy". Paper presented in XXVI EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2021), 2021.
  15. Pontes, Olívia; Sofia Oliveira-Pinto; Diogo Lopes; Belém Sampaio-Marques; Luísa Carvalho; Gonçalves, Céline S.; Bruno M. Costa; et al. "Characterization of the biological activity of functionalized chromeno[2,3b]pyridines for breast cancer treatment". Paper presented in LPCC Webinar Cancer Biology: From Basic to Translational Research, 2020.
  16. Martins, Eduarda P.; Gonçalves, Céline S.; Pojo, Marta; Carvalho, Rita; Ribeiro, Ana S.; Taipa, Ricardo; Faria, Cláudia C.; et al. "CDH3/P-cadherin is a novel oncogenic biomarker with prognostic value in glioblastoma". Paper presented in EACR-AACR-ASPIC Basic and Translational Research Conference, 2020.
  17. Gonçalves, Céline S.; Vieira de Castro, Joana; Xavier-Magalhães, Ana; Martins, Eduarda P.; Pojo, Marta; Queirós, Sandro; Faria, Cláudia C.; et al. "Deciphering WNT6 up and down roads in glioblastoma: mechanistic, functional, and clinical insight". Paper presented in EACR-AACR-ASPIC Basic and Translational Research Conference, 2020.
  18. Martins, Eduarda P.; Pojo, Marta; Gonçalves, Céline S.; Carvalho, Rita; Ribeiro, Ana S.; Taipa, Ricardo; Pardal, Fernando; et al. "Functional and prognostic relevance of CDH3/P-cadherin in glioblastoma". Paper presented in 6th Annual Meeting ISCaM, 2019.
  19. Gonçalves, Céline S.; Vieira de Castro, Joana; Pojo, Marta; Martins, Eduarda P.; Queirós, Sandro; Chautard, Emmanuel; Taipa, Ricardo; et al. "WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma". Paper presented in 6th Annual Meeting ISCaM, 2019.
  20. Gonçalves, Céline S.; Vieira de Castro, Joana; Xavier-Magalhães, Ana; Martins, Eduarda P.; Pojo, Marta; Queirós, Sandro; Chautard, Emmanuel; et al. "Deciphering key roles of WNT6 in glioblastoma: mechanistic, functional, and clinical insights". Paper presented in 10th Brain Tumor Meeting, 2019.
  21. Martins, Eduarda P.; Pojo, Marta; Gonçalves, Céline S.; Carvalho, Rita; Ribeiro, Ana S.; Pardal, Fernando; Pinto, Afonso A.; et al. "CDH3/P-cadherin expression is associated with aggressiveness of human glioblastoma". Paper presented in 3rd ASPIC International Congress, 2018.
  22. Martins, Eduarda P.; Pojo, Marta; Gonçalves, Céline S.; Carvalho, Rita; Ribeiro, Ana S.; Pardal, Fernando; Pinto, Afonso A.; et al. "CDH3/P-cadherin as a novel biomarker in glioblastoma: functional and prognostic insights". Paper presented in 25th Porto Cancer Meeting, 2018.
  23. Gonçalves, Céline S.; Vieira de Castro, Joana; Pojo, Marta; Martins, Eduarda P.; Queirós, Sandro; Chautard, Emmanuel; Taipa, Ricardo; et al. "WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma". Paper presented in 25th Porto Cancer Meeting, 2018.
  24. Gonçalves, Céline S.; Vieira de Castro, Joana; Pojo, Marta; Martins, Eduarda P.; Queirós, Sandro; Chautard, Emmanuel; Taipa, Ricardo; et al. "WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma". Paper presented in 2nd ICVS Open Day, 2018.
  25. Martins, Eduarda P.; Pojo, Marta; Gonçalves, Céline S.; Carvalho, Rita; Ribeiro, Ana S.; Pardal, Fernando; Pinto, Afonso A.; et al. "Functional impact and prognostic relevance of CDH3/P-cadherin in glioblastoma". Paper presented in 2nd ICVS Open Day, 2018.
  26. Vieira de Castro, Joana; Miranda-Lorenzo, Irene; Gonçalves, Céline S.; Cerqueira, Mariana T.; Pinto, Afonso A.; Reis, Rui L.; Sousa, Nuno; Heeschen, Christopher; Costa, Bruno M.. "Intracellular autofluorescence: a new biomarker for Glioblastoma Stem Cells". Paper presented in X National Meeting of the Portuguese Association of Neuro-Oncology, 2017.
  27. Gonçalves, Céline S.; Pojo, Marta; Xavier-Magalhães, Ana; Vieira de Castro, Joana; Miranda-Gonçalves, Vera; Pinto, Afonso A.; Taipa, Ricardo; et al. "WNT6 regulation in Glioblastoma: Mechanistic, Functional and Clinical implications". Paper presented in 1st ICVS Open Day, 2017.
  28. Gonçalves, Céline S.; Pojo, Marta; Xavier-Magalhães, Ana; Vieira de Castro, Joana; Miranda-Gonçalves, Vera; Pinto, Afonso A.; Taipa, Ricardo; et al. "WNT6 regulation in glioblastoma: mechanistic, functional and clinical implications". Paper presented in XV meeting of the Portuguese Society for Neuroscience, 2017.
  29. Martins, Eduarda P.; Pojo, Marta; Ribeiro, Ana S.; Gonçalves, Céline S.; Miranda-Gonçalves, Vera; Taipa, Ricardo; Pardal, Fernando; et al. "CDH3/P-cadherin as a putative HOXA9 target in gliomas: functional and clinical relevance". Paper presented in XV meeting of the Portuguese Society for Neuroscience, 2017.
  30. Vieira de Castro, Joana; Miranda-Lorenzo, Irene; Gonçalves, Céline S.; Cerqueira, Mariana T.; Pinto, Afonso A.; Reis, Rui L.; Sousa, Nuno; Heeschen, Christopher; Costa, Bruno M.. "Intracellular autofluorescence: a new biomarker for Glioblastoma Stem Cells". Paper presented in XV meeting of the Portuguese Society for Neuroscience, 2017.
  31. Gonçalves, Céline S.; Pojo, Marta; Xavier-Magalhães, Ana; Vieira de Castro, Joana; Miranda-Gonçalves, Vera; Pinto, Afonso A.; Taipa, Ricardo; et al. "WNT6 regulation in glioblastoma: mechanistic, functional and clinical implications". Paper presented in 24th Porto Cancer Meeting, 2017.
  32. Vieira de Castro, Joana; Miranda-Lorenzo, Irene; Gonçalves, Céline S.; Cerqueira, Mariana T.; Pinto, Afonso A.; Reis, Rui L.; Sousa, Nuno; Heeschen, Christopher; Costa, Bruno M.. "Intracellular autofluorescence: a new biomarker for Glioblastoma Stem Cells”". Paper presented in 24th Porto Cancer Meeting, 2017.
  33. Martins, Eduarda P.; Pojo, Marta; Ribeiro, Ana S.; Gonçalves, Céline S.; Miranda-Gonçalves, Vera; Taipa, Ricardo; Pardal, Fernando; et al. "CDH3/P-cadherin as a putative HOXA9 target in gliomas: functional and clinical relevance". Paper presented in 24th Porto Cancer Meeting, 2017.
  34. Gonçalves, Céline S.; Pojo, Marta; Xavier-Magalhães, Ana; Vieira de Castro, Joana; Pinto, Afonso A.; Taipa, Ricardo; Pardal, Fernando; et al. "Regulation of WNT6 by HOXA9 in glioblastoma: functional and clinical relevance". Paper presented in 2nd ASPIC International Congress, 2016.
    10.1158/2326-6074.tumimm17-b44
  35. Pojo, Marta; Gonçalves, Céline S.; Xavier-Magalhães, Ana; Fernandes, Ricardo; Gonçalves, Tiago; Rodrigues, Ana J.; Costa, Sandra; et al. "A Transcriptomic Signature Mediated by HOXA9 Sustains Human Glioblastoma Aggressiveness and Resistance to Chemotherapy". Paper presented in II International Symposium on Clinical and Basic Investigation in Glioblastoma, 2015.
  36. Gonçalves, Céline S.; Pojo, Marta; Xavier-Magalhães, Ana; Pinto, Afonso A.; Clara, Carlos; Taipa, Ricardo; Pires, Manuel M.; et al. "HOXA9-mediated activation of the WNT pathway: functional and clinical relevance in glioblastoma". Paper presented in XXIII Porto Cancer Meeting – Stem Cells and Cancer, 2015.
  37. Vieira de Castro, Joana; Gonçalves, Céline S.; Costa, Sandra; Linhares, Paulo; Vaz, R.; Nabiço, R.; Amorim, Júlia; et al. "Impact of TGF-ß1 -509C/T and 869T/C polymorphisms on glioma risk and patient prognosis". Paper presented in XXIII Porto Cancer Meeting – Stem Cells and Cancer, 2015.
  38. Pojo, Marta; Gonçalves, Céline S.; Xavier-Magalhães, Ana; Oliveira, Ana I.; Gonçalves, Tiago; Correia, Sara; Rodrigues, Ana J.; et al. "A Transcriptomic Signature Mediated by HOXA9 Promotes Human Glioblastoma Initiation, Aggressiveness and Resistance to Temozolomide". Paper presented in EACR –OECI Conference on Precision Medicine for Cancer, 2015.
  39. Gonçalves, Céline S.; Pojo, Marta; Xavier-Magalhães, Ana; Pinto, Afonso A.; Clara, Carlos; Pires, Manuel M.; Pinheiro, Célia; et al. "Regulation of Wnt Signaling by HOXA9 in Glioblastoma: Mechanistic and Prognostic Insights". Paper presented in 1st ASPIC International Congress, 2014.
  40. Gonçalves, Céline S.; Xavier-Magalhães, Ana; Lourenço, Tatiana; Pojo, Marta; Lopes, M.C.; Rebelo, O.; Pinto, Afonso A.; et al. "HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma". Paper presented in 1st ASPIC International Congress, 2014.
  41. Gonçalves, Céline S.; Xavier-Magalhães, Ana; Pojo, Marta; Pinto, Afonso A.; Pires, Manuel M.; Pinheiro, Célia; Reis, Rui M.; Sousa, Nuno; Costa, Bruno M.. "WNT6 promoter methylation associates with its expression in glioblastoma". Paper presented in EMBO workshop, Epigenetic plasticity: Implications in neural (dys)function, 2014.
  42. Pojo, Marta; Gonçalves, Céline S.; Xavier-Magalhães, Ana; Oliveira, Ana I.; Gonçalves, Tiago; Rodrigues, Ana J.; Costa, Sandra; et al. "A Transcriptomic Signature Mediated by HOXA9 Sustains Human Glioblastoma Aggressiveness, Resistance to Chemotherapy and Glioma Initiation". Paper presented in VI National Meeting of the Portuguese Association of Neuro-Oncology, 2013.
  43. Pojo, Marta; Gonçalves, Céline S.; Xavier-Magalhães, Ana; Fernandes, Ricardo; Gonçalves, Tiago; Rodrigues, Ana J.; Costa, Sandra; et al. "A Transcriptomic Signature Mediated by HOXA9 Sustains Human Glioblastoma Aggressiveness, Resistance to Chemotherapy and Glioma Initiation". Paper presented in EACR Summer Conference: Cancer Genomics, 2013.
  44. Gonçalves, Céline S.; Xavier-Magalhães, Ana; Lourenço, Tatiana; Pojo, Marta; Rocha, Miguel; Lopes, Maria C.; Crespo, Inês; et al. "Long Non-Coding RNA HOTAIR is Transcriptionally Activated by HOXA9 and Is Associated with Poor Prognosis in Glioblastoma.". Paper presented in Non-coding RNA, epigenetics and transgenerational inheritance (RNA2013) Meeting, 2013.
  45. Gonçalves, Céline S.; Xavier-Magalhães, Ana; Costa, Bruno M.. "Regulation of Wnt signaling by HOXA9 in Glioblastoma: Mechanistic and Prognostic Insights". Paper presented in XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting, 2013.
  46. Pojo, Marta; Gonçalves, Céline S.; Xavier-Magalhães, Ana; Fernandes, Ricardo; Gonçalves, Tiago; Rodrigues, Ana J.; Costa, Sandra; et al. "HOXA9 Promotes Glioma Initiation and Sustains Human Glioblastoma Aggressiveness and Resistance to Therapy". Paper presented in XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting, 2013.
  47. Gonçalves, Céline S.; Xavier-Magalhães, Ana; Lourenço, Tatiana; Pojo, Marta; Rocha, Miguel; Lopes, Maria C.; Crespo, Inês; et al. "Long Non-Coding RNA HOTAIR is Transcriptionally Activated by HOXA9 and Is Associated with Poor Prognosis in Glioblastoma". Paper presented in XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting, 2013.
  48. Lourenço, Tatiana; Gonçalves, Céline S.; Xavier-Magalhães, Ana; Pinto, F.; Reis, Rui M.; Costa, Bruno M.. "Relevance of HES1 expression in human gliomas: molecular and clinical correlates". Paper presented in XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting, 2013.
  49. Gonçalves, Céline S.; Xavier-Magalhães, Ana; Pojo, Marta; Rocha, Miguel; Sousa, Nuno; Costa, Bruno M.. "Regulation of WNT6 expression by HOXA9 in glioblastoma and prognostic implications". Paper presented in 6th National Meeting on Cell Signaling, 2012.
  50. Gonçalves, Céline S.; Xavier-Magalhães, Ana; Rocha, Miguel; Sousa, Nuno; Costa, Bruno M.. "HOXA9 transcriptome analysis in Glioblastoma: The bioinformatics beyond the bench". Paper presented in Bioinformatics Open Days, 2012.
  51. Duarte, Vera CM; Fortes, António Gil; Alves, Maria J.; Gonçalves, Céline S.. "Enantioselective diels-alder methodology in the synthesis of (-)-1-azafagomine". Paper presented in 2nd Iberoamerican Symposium on Organic Chemistry (SIBEAQO-II), 2010.
Journal article
  1. Martins, Eduarda P.; Gonçalves, Céline S.; Peixoto, Joana; Ferreira, Joana M.; Longatto-Filho, Adhemar; Costa, Pedro M.; Osório, Nuno S.; Granja, Sara; Costa, Bruno M.. "A transcriptomic profiling reveals novel roles of Cadherin-3 in metabolic programming of glioblastoma". (2024):
    Submitted
  2. Silva, Mónica de Mendonça; Coletti, Roberta; Gonçalves, Céline S.; Martins, Eduarda P.; Costa, Bruno M.; Vinga, Susana; Lopes, Marta B.. "Updating TCGA glioma subtype classification through integration of molecular profiling data following 2016 and 2021 WHO guidelines". (2024):
    Submitted
  3. Coletti, Roberta; Carrilho, João; Martins, Eduarda P.; Gonçalves, Céline S.; Costa, Bruno; Lopes, Marta B.. "Exploring Glioma Heterogeneity: Integrative Multi-Omics Analysis to Discover Transcriptome-Methylome signatures". (2024):
    Submitted
  4. Ana Silva; Ana Félix; Mónica Cerqueira; Céline S. Gonçalves; Sampaio-Marques, B.; Longatto-Filho A; Baltazar F; Afonso J. "Effects of Lactate Transport Inhibition by AZD3965 in Muscle-Invasive Urothelial Bladder Cancer". Pharmaceutics 15 12 (2023): 2688; IF=5.4. https://www.mdpi.com/1999-4923/15/12/2688;.
    10.3390/pharmaceutics15122688
  5. Afonso, Julieta; Gonçalves, Céline S.; Costa, Marta; Ferreira, Débora; Santos, Lúcio; Longatto-Filho, Adhemar; Baltazar, Fátima. "Glucose Metabolism Reprogramming in Bladder Cancer: Hexokinase 2 (HK2) as Prognostic Biomarker and Target for Bladder Cancer Therapy". Cancers 15 3 (2023): 982; IF=5.2. http://dx.doi.org/10.3390/cancers15030982.
    Published • 10.3390/cancers15030982
  6. Outeiro-Pinho, Gonçalo; Barros-Silva, Daniela; Moreira-Silva, Filipa; Lobo, João; Carneiro, Isa; Morais, António; Martins, Eduarda P; et al. "Epigenetically-regulated miR-30a/c-5p directly target TWF1 and hamper ccRCC cell aggressiveness". Translational Research 249 (2022): 110-127; IF=7.8. https://www.translationalres.com/article/S1931-5244(22)00141-4/fulltext.
    Published
  7. Lopes, Marta; Vieira de Castro, Joana; Pojo, Marta; Gonçalves, Céline S.; Martins, Eduarda P.; Coimbra, Bárbara; Sotiropoulos, Ioannis; et al. "Chronic Stress Does Not Influence the Survival of Mouse Models of Glioblastoma". Frontiers in Oncology 12 (2022): 856210; IF=4.7. http://dx.doi.org/10.3389/fonc.2022.856210.
    10.3389/fonc.2022.856210
  8. Martins-Lima, Cláudia; Miranda-Gonçalves, Vera; Lobo, João; Constâncio, Vera; Leite-Silva, Pedro; Guimarães-Teixeira, Catarina; Monteiro-Reis, Sara; et al. "Cadherin switches during epithelial-mesenchymal transition: CDH4/RCAD downregulation reduces bladder cancer progression". Cellular Oncology 45 1 (2022): 135-149; IF=6.6. http://dx.doi.org/10.1007/s13402-021-00657-2.
    Published • 10.1007/s13402-021-00657-2
  9. Martins, Eduarda P.; Gonçalves, Céline S.; Pojo, Marta; Carvalho, Rita; Ribeiro, Ana S.; Miranda-Gonçalves, Vera; Taipa, Ricardo; et al. Corresponding author: Costa, Bruno M.. "Cadherin-3 is a novel oncogenic biomarker with prognostic value in glioblastoma". Molecular Oncology 16 14 (2021): 2611-2631; IF=7.4. http://dx.doi.org/10.1002/1878-0261.13162.
    Open access • Published • 10.1002/1878-0261.13162
  10. Miranda-Gonçalves, Vera; Gonçalves, Céline S.; Granja, Sara; Vieira de Castro, Joana; Reis, Rui M.; Costa, Bruno M.; Baltazar, Fátima. "MCT1 Is a New Prognostic Biomarker and Its Therapeutic Inhibition Boosts Response to Temozolomide in Human Glioblastoma". Cancers 13 14 (2021): 3468; IF=6.6. http://dx.doi.org/10.3390/cancers13143468.
    Open access • Accepted • 10.3390/cancers13143468
  11. Oliveira, Catarina; Gonçalves, Céline S.; Martins, Eduarda P.; Neves, Nuno M.; Reis, Rui L.; Costa, Bruno M.; Silva, Tiago H.; Martins, Albino. "Functionalized Marine-Polymeric Nanoparticles Targeting ErbB-2 Impair Breast Cancer Cells Growth and Metastasis". International Journal of Pharmaceutics 600 (2021): 120548; IF=5.9. http://dx.doi.org/10.1016/j.ijpharm.2021.120548.
    Accepted • 10.1016/j.ijpharm.2021.120548
  12. Vieira de Castro, Joana; Gonçalves, Céline S.; Martins, Eduarda P.; Miranda-Lorenzo, Irene; Cerqueira, Mariana T.; Longatto-Filho, A.; Pinto, Afonso A.; et al. "Intracellular autofluorescence as a new biomarker to identify Glioblastoma Stem Cells". Cancers 13 4 (2021): 828; IF=6.6. http://dx.doi.org/10.3390/cancers13040828.
    Open access • Published • 10.3390/cancers13040828
  13. Gonçalves, Céline S.; Vieira de Castro, Joana; Hormigo, Adília; Costa, Bruno M.. "Exploiting the Complexities of Glioblastoma Stem Cells: Insights for Cancer Initiation and Therapeutic Targeting". International Journal of Molecular Sciences 21 15 (2020): 5278; IF=6.6. http://dx.doi.org/10.3390/ijms21155278.
    Open access • Published • 10.3390/ijms21155278
  14. Oliveira-Pinto, Sofia; Pontes, Olívia; Lopes, Diogo; Sampaio-Marques, Belém; Costa, Marta D.; Carvalho, Luísa; Gonçalves, Céline S.; et al. "Unravelling the anticancer potential of functionalized chromeno[2,3-b]pyridines for breast cancer treatment". Bioorganic Chemistry 100 (2020): 103942; IF=5.3. http://dx.doi.org/10.1016/j.bioorg.2020.103942.
    In press • 10.1016/j.bioorg.2020.103942
  15. Outeiro-Pinho, Gonçalo; Barros-Silva, Daniela; Aznar, Elena; Sousa, Ana I.; Vieira-Coimbra, Márcia; Oliveira, Jorge; Gonçalves, Céline S.; et al. "MicroRNA-30a-5pme: a novel diagnostic and prognostic biomarker for clear cell renal cell carcinoma in tissue and urine samples". Journal of Experimental & Clinical Cancer Research 39 1 (2020): 98; IF=11.2. http://dx.doi.org/10.1186/s13046-020-01600-3.
    Open access • Published • 10.1186/s13046-020-01600-3
  16. Monteiro-Reis, Sara; Lameirinhas, Ana; Miranda-Gonçalves, Vera; Felizardo, Diana; Dias, Paula C.; Oliveira, Jorge; Graça, Inês; et al. "Sirtuins' Deregulation in Bladder Cancer: SIRT7 Is Implicated in Tumor Progression through Epithelial to Mesenchymal Transition Promotion". Cancers 12 5 (2020): 1066; IF=6.6. http://dx.doi.org/10.3390/cancers12051066.
    Published • 10.3390/cancers12051066
  17. Gonçalves, Céline S.; Le Boiteux, Elisa; Arnaud, Philippe; Costa, Bruno M.. "HOX gene cluster (de)regulation in brain: from neurodevelopment to malignant glial tumours". Cellular and Molecular Life Sciences 77 19 (2020): 3797-3821; IF=9.3. http://dx.doi.org/10.1007/s00018-020-03508-9.
    Published • 10.1007/s00018-020-03508-9
  18. Gonçalves, Céline S.; Xavier-Magalhães, Ana; Martins, Eduarda P.; Pinto, Afonso A.; Pires, Manuel Melo; Pinheiro, Célia; Reis, Rui M.; Sousa, Nuno; Costa, Bruno M.. "A novel molecular link between HOXA9 and WNT6 in glioblastoma identifies a subgroup of patients with particular poor prognosis". Molecular Oncology 14 6 (2020): 1224-1241; IF=6.6. http://dx.doi.org/10.1002/1878-0261.12633.
    Open access • Published • 10.1002/1878-0261.12633
  19. Estevão-Pereira, Helena; Lobo, João; Salta, Sofia; Amorim, Maria; Lopes, Paula; Cantante, Mariana; Reis, Berta; et al. "Overexpression of circulating MiR-30b-5p identifies advanced breast cancer". Journal of Translational Medicine 17 1 (2019): 1-10; IF=4.1. http://dx.doi.org/10.1186/s12967-019-02193-y.
    Published • 10.1186/s12967-019-02193-y
  20. Gonçalves, Céline S.; Vieira de Castro, Joana; Pojo, Marta; Martins, Eduarda P.; Queirós, Sandro; Chautard, Emmanuel; Taipa, Ricardo; et al. "WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma". Theranostics 8 17 (2018): 4805-4823; IF=8.1. http://dx.doi.org/10.7150/thno.25025.
    Open access • Published • 10.7150/thno.25025
  21. Ramalho-Carvalho, J.; Gonçalves, C.S.; Graça, I.; Bidarra, D.; Pereira-Silva, E.; Salta, S.; Godinho, M.I.; et al. "A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97". Clinical Epigenetics 10 1 (2018): 40; IF=5.5. http://dx.doi.org/10.1186/s13148-018-0475-2.
    Open access • Published • 10.1186/s13148-018-0475-2
  22. Gonçalves, C.S.; Xavier-Magalhães, A.; Fogli, A.; Lourenço, T.; Pojo, M.; Pereira, B.; Rocha, M.; et al. "The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma". Oncotarget 9 21 (2018): 15740-15756. http://dx.doi.org/10.18632/oncotarget.24597.
    Open access • Published • 10.18632/oncotarget.24597
  23. Ferreira, M.J.; Pires-Luís, A.S.; Vieira-Coimbra, M.; Costa-Pinheiro, P.; Antunes, L.; Dias, P.C.; Lobo, F.; et al. "SETDB2 and RIOX2 are differentially expressed among renal cell tumor subtypes, associating with prognosis and metastization". Epigenetics 12 12 (2017): 1057-1064; IF=4.9. http://dx.doi.org/10.1080/15592294.2017.1385685.
    Open access • Published • 10.1080/15592294.2017.1385685
  24. Xavier-Magalhães, A.; Oliveira, A.I.; de Castro, J.V.; Pojo, M.; Gonçalves, C.S.; Lourenço, T.; Viana-Pereira, M.; et al. "Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis". Journal of Neuro-Oncology 132 1 (2017): 27-34; IF=3.1. http://dx.doi.org/10.1007/s11060-016-2345-0.
    Published • 10.1007/s11060-016-2345-0
  25. Almeida-Rios, D.; Graça, I.; Vieira, F.Q.; Ramalho-Carvalho, J.; Pereira-Silva, E.; Martins, A.T.; Oliveira, J.; et al. "Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer". Oncotarget 7 33 (2016): 53018-53028; IF=5.2. http://dx.doi.org/10.18632/oncotarget.10061.
    Open access • Published • 10.18632/oncotarget.10061
  26. Pires-Luís, A.S.; Vieira-Coimbra, M.; Vieira, F.Q.; Costa-Pinheiro, P.; Silva-Santos, R.; Dias, P.C.; Antunes, L.; et al. "Expression of histone methyltransferases as novel biomarkers for renal cell tumor diagnosis and prognostication". Epigenetics 10 11 (2015): 1033-1043; IF=4.8. http://dx.doi.org/10.1080/15592294.2015.1103578.
    Open access • Published • 10.1080/15592294.2015.1103578
  27. Gonçalves, Céline S.; Xavier-Magalhães, A.; Pojo, M.; Oliveira, A.I.; Correia, S.; Reis, R.M.; Sousa, N.; Rocha, M.; Costa, B.M.. "Transcriptional profiling of HOXA9-regulated genes in human glioblastoma cell models". Genomics Data 5 (2015): 54-58. http://dx.doi.org/10.1016/j.gdata.2015.05.010.
    Open access • Published • 10.1016/j.gdata.2015.05.010
  28. Costa-Pinheiro, P.; Ramalho-Carvalho, J.; Vieira, F.Q.; Torres-Ferreira, J.; Oliveira, J.; Gonçalves, C.S.; Costa, B.M.; Henrique, R.; Jerónimo, C.. "MicroRNA-375 plays a dual role in prostate carcinogenesis". Clinical Epigenetics 7 1 (2015): 1-14; IF=4.3. http://dx.doi.org/10.1186/s13148-015-0076-2.
    Open access • Published • 10.1186/s13148-015-0076-2
  29. Vieira de Castro, J.; Gonçalves, C.S.; Costa, S.; Linhares, P.; Vaz, R.; Nabiço, R.; Amorim, J.; et al. "Impact of TGF-ß1 -509C/T and 869T/C polymorphisms on glioma risk and patient prognosis". Tumor Biology 36 8 (2015): 6525-6532; IF=2.9. http://dx.doi.org/10.1007/s13277-015-3343-0.
    Published • 10.1007/s13277-015-3343-0
  30. Pojo, M.; Gonçalves, C.S.; Xavier-Magalhães, A.; Oliveira, A.I.; Gonçalves, T.; Correia, S.; Rodrigues, A.J.; et al. "A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide". Oncotarget 6 10 (2015): 7657-7674; IF=5. http://dx.doi.org/10.18632/oncotarget.3150.
    Open access • Published • 10.18632/oncotarget.3150
Preprint
  1. Mónica L. Medonça; Roberta Coletti; Céline S. Gonçalves; Eduarda P. Martins; Bruno M. Costa; Susana Vinga; Marta B. Lopes; et al. "Updating TCGA glioma classification through integration of molecular profiling data following the 2016 and 2021 WHO guidelines". 2023. https://doi.org/10.1101/2023.02.19.529134.
    10.1101/2023.02.19.529134
Thesis / Dissertation
  1. Gonçalves, Céline S.. "Deciphering key roles of WNT6 in glioblastoma: mechanistic, functional, and clinical insights". PhD, Universidade do Minho Escola de Medicina, 2018.
  2. Gonçalves, Céline S.. "The Transcriptome of the Oncogenic HOXA9 Homeoprotein in Human Glioblastoma: Functional and Clinical Relevance". Master, Universidade do Minho Escola de Ciências da Saúde, 2013.

Intellectual property

Patent
  1. Serpa, Jacinta; Martins, Filipa; Gonçalves, Céline S.; Costa, Bruno M.; Martins, Eduarda P. 2023. "A novel and promising glutaminase 1 (GLS1)-based systemic therapy in glioblastoma (GBM) - Portuguese Patent (PT118918)". Portugal.
    Pending
  2. Gonçalves, Céline S.; Sousa, Nuno; Costa, Bruno M.. 2019. "A novel oncogene biomarker, methods and uses thereof - International Patent (WO2019207512A2)".
    Granted/Issued
  3. Gonçalves, Céline S.; Sousa, Nuno; Costa, Bruno M.. 2018. "A novel oncogene biomarker, methods and uses thereof - Portuguese Patent (PT110707)".
    Granted/Issued
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/04/29 Exploiting the Relevance of WNT6 in Extracellular Vesicles of Glioblastoma: Clinical and Molecular Insights 6th ASPIC International Congress
ASPIC (Faro, Portugal)
2024/02/02 Novel roles of Cadherin-3 in the metabolic reprogramming of glioblastoma XIV Portuguese Association of Neuro-Oncology National Congress
Portuguese Association for Neuro-Oncology (Lisbon, Portugal)
2024/02/02 Exploiting the relevance of WNT6 in Extracellular Vesicles of Glioblastoma: Clinical and Molecular Insights XIV Portuguese Association of Neuro-Oncology National Congress
Portuguese Association for Neuro-Oncology (Lisbon, Portugal)
2022/07/01 Cadherin-3 is a novel oncogenic biomarker with prognostic value in glioblastoma 5th ASPIC International Congress
ASPIC (Porto, Portugal)
2021/10/15 CDH3/P-Cadherin is a novel oncogenic biomarker with prognostic value in glioblastoma XII Congresso Nacional da Associação Portuguesa de Neuro-Oncologia
Portuguese Association for Neuro-Oncology (Portugal)
2021/10/14 CDH3/P-Cadherin is a novel oncogenic biomarker with prognostic value in glioblastoma II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer
ASPIC-ASEICA - Speed talk format (Porto, Portugal)
2021/01/29 Characterization of the activity of novel chromene derivatives for cancer therapy II Symposium on Biochemistry
School of Sciences, University of Minho (Braga, Portugal)
2020/09 Characterization of the biological activity of functionalized chromeno[2,3b]pyridines for breast cancer treatment 2nd National Meeting of Young Investigators in Oncology
Portuguese League Against Cancer (Porto, Portugal)
2020/05 Marine-polymeric nanoparticles functionalized with ErbB-2 antibody impair breast cancer cells growth and metastasis. World Biomaterials Congress 2020
WBC (Glasgow, United Kingdom)
2020/03/07 CDH3/P-cadherin is a novel oncogenic biomarker with prognostic value in glioblastoma (postponed due to COVID-19) XII Congresso Nacional da Associação Portuguesa de Neuro-Oncologia
Portuguese Association for Neuro-Oncology (Coimbra, Portugal)
2019/05/02 Deciphering key roles of WNT6 in glioblastoma: mechanistic, functional, and clinical insights 26th Porto Cancer Meeting
PCM - Speed talk format (Porto, Portugal)
2019/05/02 Functional and prognostic relevance of CDH3/P-cadherin in glioblastoma 26th Porto Cancer Meeting
PCM - Speed talk format (Porto, Portugal)
2019/01/19 Deciphering key roles of WNT6 in glioblastoma: mechanistic, functional, and clinical insight XI Congresso Nacional da Associação Portuguesa de Neuro-Oncologia
Portuguese Association for Neuro-Oncology (Lisbon, Portugal)
2019/01/18 CDH3/P-cadherin is an oncogenic biomarker in glioblastoma XI Congresso Nacional da Associação Portuguesa de Neuro-Oncologia
Portuguese Association for Neuro-Oncology (Lisbon, Portugal)
2018/05/10 Functional and prognostic relevance of WNT6 in human glioblastoma 3rd ASPIC International Congress
ASPIC (Lisbon, Portugal)
2017/11/10 CDH3/P-cadherin as a novel biomarker in glioblastoma: functional and prognostic insights X Congresso Nacional da Associação Portuguesa de Neuro Oncologia
Portuguese Association for Neuro-Oncology (Braga, Portugal)
2017/11/10 WNT6 as a novel oncogene in human glioblastoma: functional, mechanistic, and clinical implications X Congresso Nacional da Associação Portuguesa de Neuro Oncologia
Portuguese Association for Neuro-Oncology (Braga, Portugal)
2017/05/25 WNT6 regulation in glioblastoma: mechanistic, functional and clinical implications XV meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (Braga, Portugal)
2015/12/11 HOXA9-mediated activation of the WNT pathway: functional and clinical relevance in glioblastoma VIII Congresso Nacional da Associação Portuguesa de Neuro Oncologia
Portuguese Association for Neuro-Oncology (Lisbon, Portugal)
2015/12/11 CDH3/P-cadherin is a HOXA9 target in glioma, associated with tumor aggressiveness and prognosis of glioblastoma patients VIII Congresso Nacional da Associação Portuguesa de Neuro Oncologia
Portuguese Association for Neuro-Oncology (Lisbon, Portugal)
2014/11/25 HOXA9 Promotes Glioblastoma Initiation, Aggressiveness and Resistance to Therapy 1st ASPIC International Congress
ASPIC (Lisbon, Portugal)
2014/11/21 Relevance of the HOXA9 oncogene in Glioblastoma: effects in tumor initiation, aggressivity, and resistance to temozolomide VII Congresso Nacional de Neuro Oncologia
Portuguese Association for Neuro-Oncology (Lisbon, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09 - Current Exploiting novel molecular, cellular, and immune landscapes in glioblastoma
Supervisor
 PhD Thesis (PhD)
Universidade do Minho Escola de Medicina, Portugal
2023/01 - Current Clinical value of a WNT6-driven Molecular Signature in Glioblastoma Liquid Biopsies
Supervisor
 Master Thesis (Master)
Universidade do Minho Escola de Medicina, Portugal
2022/03 - 2023/12/05 Deciphering novel mechanisms of WNT6-driven chemotherapy resistance in human glioblastoma
Supervisor
 Master Thesis (Master)
Universidade do Minho Escola de Medicina, Portugal
2022/12 - 2023/06 Exploitation of WNT6 as a novel liquid biopsy biomarker tool for glioblastoma patients
Supervisor
 MD Master Thesis (Master)
Universidade do Minho Escola de Medicina, Portugal
2022/12 - 2023/03 WNTrack - Tracking brain tumors through their exosomes: a WNT6-driven approach
Supervisor
 Lab rotation (Master) (Other)
Universidade do Minho Escola de Medicina, Portugal
2020/03 - 2022/03/18 Unravelling the role of the spinocerebellar ataxia type 3-associated protein ATXN3 in glioblastoma
Supervisor
 Master Thesis (Master)
Universidade do Minho Escola de Medicina, Portugal
2020/07/01 - 2020/08/31 Unraveling the prognostic value of WNT6 in colorectal cancer patients: Analysis of TCGA data
Supervisor
 MD/PhD Lab Rotation (Master)
Universidade do Minho Escola de Medicina, Portugal
2020/03/16 - 2020/04/24 Exploiting the intracellular mechanisms regulating P-cadherin aggressiveness in glioblastoma
Supervisor
 Lab Rotation (PhD)
Universidade do Minho Escola de Medicina, Portugal
2019/07/01 - 2019/09/16 WNT6 overexpression effects on the viability of glioblastoma cells and its potential therapeutic targeting
Co-supervisor
 Lab Rotation (Master in Medicine)
Universidade do Minho Escola de Medicina, Portugal
2018/11/19 - 2019/06/04 The Role of WNT6 in the viability of the glioblastoma cell line GL261
Co-supervisor
 Lab rotation (Master in Medicine)
Universidade do Minho Escola de Medicina, Portugal
2015/06/01 - 2015/12/18 Long non-coding RNA HOTTIP expression and clinical impact in gliomas
Co-supervisor
 MD Master Thesis (Master in Medicine)
Universidade do Minho Escola de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2010/06/01 - 2011/04/17 2nd Biochemistry Meeting (2011/04/15 - 2011/04/17)
Meeting (President of the Organising Committee)
 Universidade do Minho Escola de Ciências, Portugal
2009/09 - 2010/04 1st Biochemistry Meeting (2010/04)
Meeting (Member of the Organising Committee)
 Universidade do Minho Escola de Ciências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/09/29 - Current Participation in the session 'Alumni MSc and PhD students - Let's catch up!' as a member of the round table to talk about my career path and experiences and discuss possible professional paths
Round table
 Postgraduate Students Retreat MSc or PhD, grab your future
Universidade do Minho Escola de Medicina, Portugal
2012 - Current Participation in editions of international, national and regional Science Outreach Activities involving children, high school students and elderly, such as: - "Portas Abertas para a Ciência"; - "Science and Technology Week"; - "Maratona da Saúde"; - "Brain Awareness Week"; - "Verão no Campus"; - "Doctor and Scientist for a Day"; - "Scientists go to schools"; - "ABC of surgery"
Universidade do Minho Escola de Medicina, Portugal
2015 - 2024 Portuguese Association for Neuro-Oncology Congress: - 2015 in Lisbon, PT; - 2017 in Braga, PT; - 2019 in Lisbon, PT; - 2024 in Lisbon.
Congress
Portuguese Association for Neuro-Oncology, Portugal
2014 - 2024 Portuguese Association for Cancer Research International Congress: - 2014 in Lisbon, PT; - 2016 in Porto, PT; - 2018 in Lisbon, PT; - 2020 in Lisbon, PT; - 2021 as Virtual Congress (due to Covid-19); - 2022 in Porto, PT; - 2023 in Porto, PT; - 2024 in Faro, PT.
Congress
Portuguese Association for Cancer Research, Portugal
2022/04/21 - 2022/05/20 Scicare - Novartis Health Science Accelerator - 1 of the 8 teams selected for the program - [Participation as Principal Investigator]
Workshop
 Total Immersion Week
Novartis Farma SA, Portugal
2021/02/03 - 2021/02/05 GliMR - Glioma Imaging Bridging Clinic and Research
Meeting
Glioma MR 2.0 COST Action, Netherlands
2020/12/02 - 2020/12/02 EARA Media Training
Workshop
European Animal Research Association, Portugal
2020/11/27 - 2020/11/27 Scicare Talks "From Science to Impact"
Symposium
Novartis Farma SA, Portugal
2020/11/13 - 2020/11/13 Animal Research 2020 and Beyond
Conference
Animal Research Tomorrow, Switzerland
2016 - 2020 European Association for Cancer Research (EACR) Congress [biennial]: - 2016 in Manchester, UK; - 2018 in Amsterdam, NL; - 2020 as Virtual Congress (due to Covid-19)
Congress
European Association For Cancer Research, United Kingdom
2019/10/17 - 2019/10/19 6th Annual Meeting of the International Society of Cancer Metabolism (ISCAM)
Meeting
International Society of Cancer Metabolism, Italy
2019/10/03 - 2019/10/03 "How to Write a Great Research Paper, and Get it Accepted by a Good Journal" by Elsevier Research Academy
Workshop
Universidade do Minho Escola de Medicina, Portugal
2019/05/23 - 2019/05/24 Brain Tumor Meeting 2019
Meeting
Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany
2013 - 2019 Porto Cancer Meeting [biennial and now annual]: - 2013, Porto, PT; - 2015, Porto, PT; - 2017, Porto, PT; - 2018, Porto, PT; - 2019, Porto, PT.
Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/09/28 - 2018/09/28 "The future of the doctorate degree" by Professor Robert Harris (Karolinska Institute, Sweden)
Workshop
Universidade do Minho Escola de Medicina, Portugal
2018/09/28 - 2018/09/28 "Getting the most out of your supervisors" by Professor Robert Harris (Karolinska Institute, Sweden)
Workshop
Universidade do Minho Escola de Medicina, Portugal
2017/05/25 - 2017/05/26 Meeting of the Portuguese Society for Neuroscience (SPN)
Meeting
Portuguese Society for Neuroscience, Portugal
2015/09/09 - 2015/09/12 GBM 2015, Toledo, Spain
Conference
Universidad de Castilla-La Mancha, Spain
2014/10/22 - 2014/10/25 Epigenetic plasticity: Implications in neural (dys)function
Workshop
 EMBO workshop
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/02/03 - 2013/02/08 Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment
Other
 SPSAS Course
São Paulo School of Advanced Science, Brazil
2011/03/04 - 2011/03/05 Pedagogical Formation’11
Workshop
Universidade do Minho, Portugal
2011/03 - 2011/03 XII Applied Biology Meeting
Meeting
Universidade do Minho Escola de Ciências, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/12 Comparative studies on transcription factors ZEB1 and ZEB2 in glioblastoma
(Thesis) Main arguer
 Inês Filipa Matos Coutinho (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2022/10 Papel da CD147 no cancro do pulmão de não pequenas células
(Thesis) Main arguer
 Sara Leonor Santos da Costa (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022/01/06 Lactate shuttle between cancer cells and tumor associated macrophages
(Thesis) Arguer
 Mariana Jeremias Macedo (Master)
Universidade do Minho Escola de Medicina, Portugal
2022/01/06 Optimization of three-dimensional cell culture models to exploit metabolic crosstalks in urothelial bladder cancer
(Thesis) Arguer
 Carolina Marques Miranda (Master)
Universidade do Minho Escola de Medicina, Portugal
2021/06/28 Assessing Ataxin-3 expression levels in cancer cells: a correlation with glioma aggressiveness?
Supervisor
 Joana Margarida Silva Ferreira (Other)
Universidade do Minho Escola de Ciências, Portugal
2021/01/06 Evaluation of CD44 expression in primary tumour of colorectal cancer and respective lymph node metastasis, using immunohistochemistry technique
(Thesis) Arguer
 Beatriz Cristina Gomes Rosa (Master)
Universidade do Minho Escola de Medicina, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024 - Current Discover Oncology (2730-6011) Springer
2023 - Current Cellular and Molecular Neurobiology (0272-4340) Springer/Plenum publishers
2023 - Current Expert Reviews in Molecular Medicine (1462-3994) Cambridge Univ Press
2022 - Current BMC Cancer (1471-2407) BMC
2022 - Current Cancers (2072-6694) MDPI
2022 - Current Scientific Reports (2045-2322) Nature Portofolio
2021/01 - Current BMC Medical Genomics (1755-8794) BMC, part of Springer Nature
2021 - Current Cells (2073-4409) MDPI
2020 - Current Clinical Epigenetics (1868-7075) BMC
2019 - Current Life Sciences (0024-3205) Elsevier
2019 - Current Cancer Management and Research (1179-1322) Dove Medical Press
2019 - Current Biomarkers in Medicine (1752-0371) Future Medicine
2019 - Current BioMed Research International (2314-6141) Hindawi Limited
2019 - Current FEBS Letters (1873-3468) Wiley (John Wiley & Sons)
2018 - Current Neuroscience (0306-4522) Elsevier

Association member

Society Organization name Role
2013 - Current Portuguese Association for Cancer Research (ASPIC) associate
2013 - Current European Association for Cancer Research (EACR) associate

Committee member

Activity description
Role 		Institution / Organization
2019 - Current Animal Welfare and Ethics Body from EM/ICVS-I3Bs, helping to ensure responsible animal experimentation policies and ethically reviewing research projects
Member
 Laboratório Associado ICVS 3B's, Portugal

Universidade do Minho Escola de Medicina, Portugal
2019 - Current Cell Culture Facilities
Coordinator
 Laboratório Associado ICVS 3B's, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/03/04 - Current Hallmarks of cancer Cancer Therapy (Pós-graduação) Universidade do Minho Escola de Ciências, Portugal
2023/04/24 - Current Hallmarks of Cancer Cancer Therapy (Pós-Graduação) Universidade do Minho Escola de Ciências, Portugal
2022 - Current Laboratory Animal Science - Pratical Sessions Laboratory Animal Science (Pós-Graduação) Universidade do Minho Escola de Medicina, Portugal
2019/10/11 - 2019/10/11 Molecular Biology of Cancer Mestrado integrado em Medicina (Pós-Graduação) Universidade do Minho Escola de Medicina, Portugal
2019/05/20 - 2019/05/20 Hallmarks of Cancer Cancer Therapy (Pós-Graduação) Universidade do Minho Escola de Ciências, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current Frontiers in Oncology [Part of the Editorial Board as Review Editor] (2234-943X) Frontiers
2020 - Current Frontiers in Cell and Developmental Biology [Part of the Editorial Board as Review Editor] (2296-634X) Frontiers
Distinctions

Award

2024 Best oral communication at XIV Portuguese Association of Neuro-Oncology National Congress
Portuguese Association for Neuro-Oncology, Portugal
2023 EACR Poster Prize at III ASPIC-ASEICA International Meeting
European Association For Cancer Research, United Kingdom

Associação Portuguesa de Investigação em Cancro, Portugal

Asociación Española de Investigación sobre el Cáncer, Spain
2019 Best oral presentation Award at the XI Congresso Nacional da Associação Portuguesa de Neuro Oncologia
Portuguese Association for Neuro-Oncology, Portugal
2019 Travel award to attend the 10th Brain Tumor Meeting 2019 in Berlin, Germany
Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany
2018 Best poster Award at the 2nd ICVS Open Day
Laboratório Associado ICVS 3B's, Portugal
2018 Best poster award at the 3rd ASPIC International Congress
European Association For Cancer Research, United Kingdom
2017 Best poster Award at the 1st ICVS Open Day
Laboratório Associado ICVS 3B's, Portugal
2017 Best oral presentation Award at the X Congresso Nacional da Associação Portuguesa de Neuro Oncologia
Portuguese Association for Neuro-Oncology, Portugal
2016 EACR24 Meeting Bursary Award
European Association For Cancer Research, United Kingdom
2014 Best oral presentation at the VII Congresso Nacional da Associação Portuguesa de Neuro Oncologia
Portuguese Association for Neuro-Oncology, Portugal
2013 Best Poster Award at the XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2013 Travel Award to attend the SPSAS course in São Paulo, Brazil
Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil
2013 Best poster Award at the VI National Meeting of the Portuguese Association of Neuro-Oncology
Portuguese Association for Neuro-Oncology, Portugal

Other distinction

2022 Grant of the Scientific Employment Stimulus (Junior Position)
Fundação para a Ciência e a Tecnologia, Portugal
2017 Scholarships for School Merit in 2012/2013 - Best MSc student
Universidade do Minho, Portugal
2014 PhD scholarship
Fundação para a Ciência e a Tecnologia, Portugal
2009 Diploma of Merit Monsenhor Elísio Araújo
Agrupamento de escolas Monsenhor Elísio de Araújo, Portugal
2005 Diploma of Merit
Rotary Club, Portugal