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I finished my graduation in Pharmaceutical Sciences in 26/06/2002 at the Faculty of Pharmacy of the University of Oporto (Portugal), and the PhD in Analytical Chemistry in 19/07/2007 at the Faculty of Pharmacy of the University of Oporto, with the thesis entitled ¿Development of multicommutated flow systems with amperometric and voltammetric detection¿. From 2008 to 2009 I worked at the Proteomics Unit ¿ IPATIMUP (Portugal) as a post-doc researcher, in the European project entitled ¿Discovery of novel cancer serum biomarkers based on aberrant post-translational modifications of O-glycoproteins, O-PTM-Biomarkers, and their application to early detection of cancer¿ (grant provided by the Seventh Framework Programme Theme HEALTH-2007-2.4.1-2 Health). From 2012 to 2021 I worked as a professor and researcher at the Autonomous University of Hidalgo State (México). I have published more than 20 research articles in specialized journals on the themes of development of analytical methodologies based in flow techniques, discovery of cancer glycobiomarkers and construction of impedimetric biosensors for the detection of cancer glycobiomarkers. I am the author of one book and two book chapters. I have received two awards. My research has been focused on Electrochemistry, Analytical Chemistry and Biotechnology applied to health issues. Since 2021 I have collaborated as e-learning teacher at the Unidade de Aprendizagem ao Longo da Vida at Universidade Aberta (Portugal), in online courses related with pharmaceutical and health sciences.
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Identification

Personal identification

Full name
Maria Luísa Soares da Silva

Citation names

  • M. Luísa S. Silva
  • M. L. S. Silva
  • Maria Luísa S. Silva

Author identifiers

Ciência ID
961D-51FD-9BF8
ORCID iD
0000-0002-1170-3962

Email addresses

  • mluisasilva78@gmail.com (Personal)

Addresses

  • Rua de São Tiago, nº 779 - Codal, 3730-520, Vale de Cambra, Vale de Cambra, Portugal (Personal)
  • Privada Sierra Chica, no. 12, Fraccionamiento Lindavista, 42180, Pachuquilla, Mineral de la Reforma, Mexico (Personal)

Knowledge fields

  • Exact Sciences - Chemical Sciences - Electrochemistry
  • Exact Sciences - Chemical Sciences - Analytical Chemistry
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2007/07/19
Concluded
 Química Analítica (Doutoramento)
Major in Sem especialidade
Universidade do Porto Faculdade de Farmácia, Portugal
"Eléctrodos com Superfícies Modificadas Como Detectores Voltamétricos e Amperométricos em Sistemas de Fluxo Multicomutado" (THESIS/DISSERTATION)
2002/06/26
Concluded
 Ciências Farmacêuticas (Licenciatura)
Universidade do Porto Faculdade de Farmácia, Portugal
"-" (THESIS/DISSERTATION)
 16 valores
Affiliation

Science

Category
Host institution 		Employer
2012/10/01 - 2021/06/30 Principal Investigator (Research) Universidad Autónoma del Estado de Hidalgo, Mexico
Universidad Autónoma del Estado de Hidalgo, Mexico
2011/09/01 - 2012/08/31 Researcher (Research) Universidad Autónoma del Estado de Hidalgo Instituto de Ciencias de la Salud, Mexico
Universidad Autónoma del Estado de Hidalgo Instituto de Ciencias de la Salud Área Académica de Farmacia, Mexico
2008/03/01 - 2009/12/31 Postdoc (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2021/10/13 - 2021/12/22 Assistant (University Teacher) Universidade Aberta Departamento de Educação e Ensino a Distância, Portugal
Universidade Aberta Departamento de Educação e Ensino a Distância, Portugal
2012/10/01 - 2021/06/30 Assistant Professor (University Teacher) Universidad Autónoma del Estado de Hidalgo, Mexico
Universidad Autónoma del Estado de Hidalgo, Mexico
2011/09/01 - 2012/08/31 Assistant Professor (University Teacher) Universidad Autónoma del Estado de Hidalgo Instituto de Ciencias de la Salud, Mexico
Universidad Autónoma del Estado de Hidalgo Instituto de Ciencias de la Salud Área Académica de Farmacia, Mexico
2010/09/01 - 2011/08/31 Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico da Guarda Escola Superior de Saúde, Portugal
Instituto Politécnico da Guarda Escola Superior de Saúde, Portugal
Outputs

Publications

Book
  1. Silva, Maria. Corresponding author: Silva, Maria. Multicommutation in Flow Analysis. Germany: LAP LAMBERT Academic Publishing. 2016.
    Published
Book chapter
  1. M. Luísa S. Silva. Corresponding author: M. Luísa S. Silva. "Lectin biosensors in cancer glycan biomarker detection". In Advances in Clinical Chemistry, 1-61. United States: Elsevier, 2019.
    Published • 10.1016/bs.acc.2019.07.001
  2. M. Luísa S. Silva. Corresponding author: M. Luísa S. Silva. "Lectins as Biorecognition Elements in Biosensors for Clinical Applications in Cancer". In Frontiers in Natural Product Chemistry: Volume 4, 156-203. United Arab Emirates: BENTHAM SCIENCE PUBLISHERS, 2018.
    Published • 10.2174/9781681087252118040007
Journal article
  1. Maria Luísa S. Silva. "Capitalizing glycomic changes for improved biomarker-based cancer diagnostics". Exploration of Targeted Anti-tumor Therapy (2023): https://doi.org/10.37349/etat.2023.00140.
    10.37349/etat.2023.00140
  2. Maria Luísa Soares da Silva. "Ferrocene-derivative Electrochemical Probe for the Selective Detection of Carcinoma-associated STn Antigen". Electroanalysis (2022): https://doi.org/10.1002/elan.202100352.
    10.1002/elan.202100352
  3. M. Luísa S. Silva; Cinthia Ramírez Martínez. "A Phaseolus vulgaris Leukoagglutinin Biosensor as a Selective Device for the Detection of Cancer-associated N -glycans with Increased ß1¿6 Branching". Electroanalysis (2021): https://doi.org/10.1002%2Felan.202100350.
    10.1002/elan.202100350
  4. Luísa S Silva M. "Microfluidic devices for glycobiomarker detection in cancer.". Clinica chimica acta; international journal of clinical chemistry (2021): http://europepmc.org/abstract/med/34273337.
    10.1016/j.cca.2021.07.013
  5. Silva. "Impedimetric Lectin-Based Biosensors for Cancer O-glycobiomarkers". Proceedings 42 1 (2020): 2-2. https://doi.org/10.3390%2Fecsa-6-06591.
    10.3390/ecsa-6-06591
  6. Rangel, María G.H.; Silva, M. Luísa S.. "Detection of the cancer-associated T antigen using an Arachis hypogaea agglutinin biosensor". Biosensors and Bioelectronics 141 (2019): 111401. http://dx.doi.org/10.1016/j.bios.2019.111401.
    Published • 10.1016/j.bios.2019.111401
  7. Silva MLS. "Lectin-based biosensors as analytical tools for clinical oncology.". Cancer letters (2018): http://europepmc.org/abstract/med/30125611.
    10.1016/j.canlet.2018.08.005
  8. M Luisa S Silva; Catarina Gomes; M Beatriz Quinaz Garcia. "Flow Lectin Affinity Chromatography-A Model with Sambucus nigra Agglutinin". Journal of Glycobiology 06 01 (2017): https://doi.org/10.4172%2F2168-958x.1000121.
    10.4172/2168-958x.1000121
  9. S. Silva, M.L.; Rangel, M.G.H.. "A Vicia villosa agglutinin biosensor for cancer-associated Tn antigen". Sensors and Actuators, B: Chemical 252 (2017): 777-784. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020808573&partnerID=MN8TOARS.
    10.1016/j.snb.2017.06.021
  10. Silva, M.L.S.. "Cancer serum biomarkers based on aberrant post-translational modifications of glycoproteins: Clinical value and discovery strategies". Biochimica et Biophysica Acta - Reviews on Cancer 1856 2 (2015): 165-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939785631&partnerID=MN8TOARS.
    10.1016/j.bbcan.2015.07.002
  11. Silva, M.L.S.; Gutiérrez, E.; Rodríguez, J.A.; Gomes, C.; David, L.. "Construction and validation of a Sambucus nigra biosensor for cancer-associated STn antigen". Biosensors and Bioelectronics 57 (2014): 254-261. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896887425&partnerID=MN8TOARS.
    10.1016/j.bios.2014.02.006
  12. M Luisa S Silva. "Comprehensive Analysis of Phytopharmaceutical Formulations–An Emphasis on Two-Dimensional Liquid Chromatography". Journal of Chromatography & Separation Techniques 06 02 (2014): https://doi.org/10.4172%2F2157-7064.1000262.
    10.4172/2157-7064.1000262
  13. Burford, B.; Gentry-Maharaj, A.; Graham, R.; Allen, D.; Pedersen, J.W.; Nudelman, A.S.; Blixt, O.; et al. "Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer". British Journal of Cancer 108 10 (2013): 2045-2055. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878554709&partnerID=MN8TOARS.
    10.1038/bjc.2013.214
  14. Gomes, C.; Almeida, A.; Ferreira, J.A.; Silva, L.; Santos-Sousa, H.; Pinto-De-Sousa, J.; Santos, L.L.; et al. "Glycoproteomic analysis of serum from patients with gastric precancerous lesions". Journal of Proteome Research 12 3 (2013): 1454-1466. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874635340&partnerID=MN8TOARS.
    10.1021/pr301112x
  15. Reis, C.A.; Osorio, H.; Silva, L.; Gomes, C.; David, L.. "Alterations in glycosylation as biomarkers for cancer detection". Journal of Clinical Pathology 63 4 (2010): 322-329. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950410995&partnerID=MN8TOARS.
    10.1136/jcp.2009.071035
  16. Silva, M.L.S.; Garcia, M.B.Q.; Lima, J.L.F.C.; Barrado, E.. "Voltammetric determination of food colorants using a polyallylamine modified tubular electrode in a multicommutated flow system". Talanta 72 1 (2007): 282-288. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947309588&partnerID=MN8TOARS.
    10.1016/j.talanta.2006.10.032
  17. Silva, M.L.S.; Garcia, M.B.Q.; Lima, J.L.F.C.; Barrado, E.. "Determination of piroxicam in pharmaceutical formulations combining amperometry and multicommutation". Electroanalysis 19 13 (2007): 1362-1367. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547605164&partnerID=MN8TOARS.
    10.1002/elan.200703856
  18. Silva, M.L.S.; Garcia, M.B.Q.; Lima, J.L.F.C.; Barrado, E.. "Modified tubular electrode in a multi-commutated flow system. Determination of acetaminophen in blood serum and pharmaceutical formulations". Analytica Chimica Acta 573-574 (2006): 383-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746011202&partnerID=MN8TOARS.
    10.1016/j.aca.2006.02.003
  19. Silva, Maria. "Flow System with Electrochemical Detection for Determination of Paracetamol in Pharmaceutical Preparations". Portugaliae Electrochimica Acta (2005):
  20. Silva, M.L.S.; Garcia, M.B.Q.; Lima, J.L.F.C.; Santos, J.L.M.; Barrado, E.. "Multicommutated flow system with amperometric detection. Determination of uric acid in urine". Electroanalysis 17 23 (2005): 2156-2162. http://www.scopus.com/inward/record.url?eid=2-s2.0-29144501622&partnerID=MN8TOARS.
    10.1002/elan.200503346

Other

Other output
  1. Detection of cancer-associated glycobiomarkers using lectin-based biosensors. 2019. M. Luísa S. Silva. https://doi.org/10.3390%2Fecmc2019-06280.
    10.3390/ecmc2019-06280
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018/01/04 - 2020/05/28 Construcción y caracterización de un biosensor de PHA-L para la detección selectiva de N-glicanos con ramificación ß1-6 aberrante asociada a carcinomas
Supervisor
Universidad Autónoma del Estado de Hidalgo, Mexico
2015/01/06 - 2019/12/10 Biosensores de lectinas para la detección selectiva de O-glicanos aberrantes como biomarcadores pan-carcinoma
Supervisor
Universidad Autónoma del Estado de Hidalgo, Mexico
2012/01/09 - 2014/01/11 Desarrollo de un biosensor para la detección de antígenos asociados a cáncer en suero sanguíneo
Co-supervisor
Universidad Autónoma del Estado de Hidalgo, Mexico

Association member

Society Organization name Role
2003/11/28 - Current Sociedade Portuguesa de Química effective member
2003/09/16 - Current Sociedade Portuguesa de Electroquímica effective member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/10/13 - 2021/12/22 Epidemiologia e Saúde Pública Epidemiologia e Saúde Pública (Outros) Universidade Aberta Departamento de Educação e Ensino a Distância, Portugal
Distinctions

Award

2019 MED.IDEAS 2019 (Concurso de Ideias), vencedora na categoria Cancro
NORTEXCELL - Centro de Excelência em Dispositivos Médicos, Portugal
2004 Prémio SIBAE 2002/ Prof.ª Inês Fonseca
Sociedade Portuguesa de Electroquímica, Portugal