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ANTÓNIO MARIA RESTOLHO MATEUS PINHEIRO. Concluiu o(a) Mestrado integrado em Mestrado Integrado em Medicina em 2017 pelo(a) Universidade do Minho Escola de Medicina, Doutoramento em Doutoramento em Ciências da Saúde em 2016 pelo(a) Universidade do Minho Escola de Medicina, Doutoramento em Doutoramento em Ciências da Saúde em 2016 pelo(a) Queen Mary University of London, Mestrado em Mestrado em Ciências da Saúde em 2011 pelo(a) Universidade do Minho Escola de Medicina e Licenciatura em Biologia Aplicada em 2009 pelo(a) Universidade do Minho Escola de Ciências. Publicou 15 artigos em revistas especializadas. Recebeu 9 prémio(s) e/ou homenagens.
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Identification

Personal identification

Full name
ANTÓNIO MARIA RESTOLHO MATEUS PINHEIRO

Citation names

  • PINHEIRO, ANTÓNIO

Author identifiers

Ciência ID
961E-C2D8-1F80
ORCID iD
0000-0002-5534-4332

Websites

  • https://www.linkedin.com/in/antónio-mateus-pinheiro-a8857554?lipi=urn%3Ali%3Apage%3Ad_flagship3_profile_view_base_contact_details%3BYnlcIIKvTC2eJxp477GrFw%3D%3D (Professional)

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2017
Concluded
 Mestrado Integrado em Medicina (Mestrado integrado)
Universidade do Minho Escola de Medicina, Portugal
"Supressão da citogénese adulta hipocampal no cérebro feminino induz hipercorticosteronemia e comportamento ansioso" (THESIS/DISSERTATION)
 16 valores
2017
Concluded
 Mestrado Integrado em Medicina (Mestrado integrado)
Universidade do Minho Escola de Medicina, Portugal
"Supressão da citogénese adulta hipocampal no cérebro feminino induz hipercorticosteronemia e comportamento ansioso" (THESIS/DISSERTATION)
 16 valores
2016
Concluded
 Doutoramento em Ciências da Saúde (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
"Adult Hippocampal Neural Plasticity: insights into its relevance in the stressed and depressed brain" (THESIS/DISSERTATION)
 Muito Bom (Distinção máxima na escala de avaliação
2016
Concluded
 Ciências da Saúde (Doutoramento)
Major in Sem especialidade
Universidade do Minho, Portugal
"Adult hippocampal neural plasticity: Insights into its functional relevance in the stressed and depressed brain" (THESIS/DISSERTATION)
 Muito Bom
2011
Concluded
 Mestrado em Ciências da Saúde (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
"Impacts of neurogenic modulatory events on neurobiology of Depression" (THESIS/DISSERTATION)
 18 valores (20 valores na Tese)
2009
Concluded
 Biologia Aplicada (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Análise Funcional e Estrutural dos Genes RIP-like em Arabidopsis thaliana" (THESIS/DISSERTATION)
 18 valores (Aluno com a classificação mais elevada
2006
Concluded
 Área Científica (Ensino secundário)
Escola Secundária D. Sancho II, Portugal
"n/a" (THESIS/DISSERTATION)
 19 valores
Projects

Contract

Designation Funders
2016/07/01 - 2020/06/30 Uma nova abordagem multimodal preditiva dos efeitos dos antidepressivos na recuperação, remissão e recorrência da depressão.
PTDC/DTP-PIC/6936/2014
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/02/01 - 2016/01/31 EPIGENETIC MODULATION OF HIPPOCAMPAL NEUROPLASTICITY: IMPACTS FOR DEPRESSION
SFRH/BD/77490/2011
Universidade do Minho Centro de Engenharia Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference paper
  1. Luís Calafate; António Mateus-Pinheiro. "Neurogénese em mamíferos adultos - história de uma descoberta revolucionária e sua exploração no ensino das neurociências". 2019.
Journal article
  1. Duarte, Joana Mendes; Gaspar, Rita; Caetano, Liliana; Patrício, Patrícia; Cunha, Carina Isabel Soares; Pinheiro, António Maria Restolho Mateus; Alves, Nuno Dinis Lopes Oliveira; et al. "Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats". (2019): http://hdl.handle.net/1822/57820.
    10.1002/glia.23476
  2. Antonio Mateus-Pinheiro; Nuno Dinis Alves; Nuno Sousa; Luisa Pinto. "AP2¿: A New Player on Adult Hippocampal Neurogenesis Regulation". Journal of Experimental Neuroscience 12 (2018): 117906951876689-117906951876689. https://doi.org/10.1177/1179069518766897.
    10.1177/1179069518766897
  3. Alves, Nuno D.; Patrício, Patrícia; Correia, Joana S.; Mateus-Pinheiro, António; Machado-Santos, Ana R.; Loureiro-Campos, Eduardo; Morais, Mónica; et al. "Chronic stress targets adult neurogenesis preferentially in the suprapyramidal blade of the rat dorsal dentate gyrus". (2018): http://hdl.handle.net/1822/57780.
    10.1007/s00429-017-1490-3
  4. Mateus-Pinheiro, A.; Alves, N.D.; Patrício, P.; Machado-Santos, A.R.; Loureiro-Campos, E.; Silva, J.M.; Sardinha, V.M.; et al. "AP2¿ 3 controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior". Molecular Psychiatry 22 12 (2017): 1725-1734. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992390012&partnerID=MN8TOARS.
    10.1038/mp.2016.169
  5. Dioli, C.; Patrício, P.; Trindade, R.; Pinto, L.G.; Silva, J.M.; Morais, M.; Ferreiro, E.; et al. "Tau-dependent suppression of adult neurogenesis in the stressed hippocampus". Molecular Psychiatry 22 8 (2017): 1110-1118. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026899195&partnerID=MN8TOARS.
    10.1038/mp.2017.103
  6. Caetano, L.; Pinheiro, H.; Patrício, P.; Mateus-Pinheiro, A.; Alves, N.D.; Coimbra, B.; Baptista, F.I.; et al. "Adenosine A 2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety". Molecular Psychiatry 22 7 (2017): 1035-1043. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991030115&partnerID=MN8TOARS.
    10.1038/mp.2016.173
  7. Alves, N.D.; Patrício, P.; Correia, J.S.; Mateus-Pinheiro, A.; Machado-Santos, A.R.; Loureiro-Campos, E.; Morais, M.; et al. "Chronic stress targets adult neurogenesis preferentially in the suprapyramidal blade of the rat dorsal dentate gyrus". Brain Structure and Function (2017): 1-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028750066&partnerID=MN8TOARS.
    10.1007/s00429-017-1490-3
  8. Morais, M.; Patrício, P.; Mateus-Pinheiro, A.; Alves, N.D.; MacHado-Santos, A.R.; Correia, J.S.; Pereira, J.; et al. "The modulation of adult neuroplasticity is involved in the mood-improving actions of atypical antipsychotics in an animal model of depression". Translational Psychiatry 7 6 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85020410481&partnerID=MN8TOARS.
    10.1038/tp.2017.120
  9. Morais, Mónica Susana Dias; Patrício, Patrícia Carvalho; Pinheiro, António Maria Restolho Mateus; Alves, Nuno Dinis Lopes Oliveira; Santos, Ana Rita Machado dos; Correia, Joana Sofia Silva; Pereira, J.; et al. "The modulation of adult neuroplasticity is involved in the mood-improving actions of atypical antipsychotics in an animal model of depression". (2017): http://hdl.handle.net/1822/49607.
    10.1038/tp.2017.120
  10. Alves, Nuno Dinis Lopes Oliveira; Silva-Correia, Joana; Patrício, Patrícia Carvalho; Pinheiro, António Maria Restolho Mateus; Machado-Santos, Ana R.; Loureiro-Campos, Eduardo; Morais, Mónica; et al. "Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression". (2017): http://hdl.handle.net/1822/49594.
    10.1038/tp.2017.29
  11. Pinheiro, António Maria Restolho Mateus; Alves, N. D.; Patrício, Patrícia Carvalho; Santos, Ana Rita Machado dos; Campos, E. Loureiro; Silva, Joana Margarida Gonçalves Mota; Sardinha, Vanessa Alexandra Morais; et al. "AP2¿ controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior". (2017): http://hdl.handle.net/1822/49593.
    10.1038/mp.2016.169
  12. Salgado, A.J.; Sousa, J.C.; Costa, B.M.; Pires, A.O.; Mateus-Pinheiro, A.; Teixeira, F.G.; Pinto, L.; Sousa, N.. "Mesenchymal stem cells secretome as a modulator of the neurogenic niche: Basic insights and therapeutic opportunities". Frontiers in Cellular Neuroscience 9 JULY (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84937392771&partnerID=MN8TOARS.
    10.3389/fncel.2015.00249
  13. Patrício, P.; Mateus-Pinheiro, A.; Irmler, M.; Alves, N.D.; Machado-Santos, A.R.; Morais, M.; Correia, J.S.; et al. "Differential and Converging Molecular Mechanisms of Antidepressants' Action in the Hippocampal Dentate Gyrus". Neuropsychopharmacology 40 2 (2015): 338-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929660426&partnerID=MN8TOARS.
    10.1038/npp.2014.176
  14. Patrício, P.; Pinheiro, António Mateus; Irmler, Martin; Alves, Nuno D.; Santos, Ana R. Machado; Morais, Mónica; Silva-Correia, Joana; et al. "Differential and converging molecular mechanisms of antidepressants' action in the hippocampal dentate gyrus". (2015): http://hdl.handle.net/1822/32923.
    10.1038/npp.2014.176
  15. Mateus-Pinheiro, A.; Patrício, P.; Alves, N.D.; Machado-Santos, A.R.; Morais, M.; Bessa, J.M.; Sousa, N.; Pinto, L.. "The Sweet Drive Test: Refining phenotypic characterization of anhedonic behavior in rodents". Frontiers in Behavioral Neuroscience 8 MAR (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84896934696&partnerID=MN8TOARS.
    10.3389/fnbeh.2014.00074
  16. Morais, M.; Santos, P.A.R.; Mateus-Pinheiro, A.; Patrício, P.; Pinto, L.; Sousa, N.; Pedroso, P.; et al. "The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition". Journal of Psychopharmacology 28 12 (2014): 1178-1183. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911109619&partnerID=MN8TOARS.
    10.1177/0269881114553646
  17. Pinheiro, António Mateus; Patrício, P.; Alves, N. D.; Santos, Ana R. Machado; Morais, Mónica; Bessa, J. M.; Sousa, Nuno; Pinto, Luisa. "The sweet drive test : refining phenotypic characterization of anhedonic behavior in rodents". (2014): http://hdl.handle.net/1822/32525.
    10.3389/fnbeh.2014.00074
  18. Bessa, J. M.; Pinto, Luisa; Morais, Mónica; Sousa, Nuno; Patrício, P.; Pinheiro, António Mateus; Almeida, Susana; et al. "The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.". (2014): http://hdl.handle.net/1822/32362.
    10.1177/0269881114553646
  19. Mateus-Pinheiro, A.; Pinto, L.; Bessa, J.M.; Morais, M.; Alves, N.D.; Monteiro, S.; Patrício, P.; Almeida, O.F.; Sousa, N.. "Sustained remission from depressive-like behavior depends on hippocampal neurogenesis.". Translational psychiatry 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879414589&partnerID=MN8TOARS.
    10.1038/tp.2012.141
  20. Patrício, P.; Mateus-Pinheiro, A.; Sousa, N.; Pinto, L.. "Re-cycling paradigms: Cell cycle regulation in adult hippocampal neurogenesis and implications for depression". Molecular Neurobiology 48 1 (2013): 84-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880924582&partnerID=MN8TOARS.
    10.1007/s12035-013-8422-x
  21. Mateus-Pinheiro, A.; Patrício, P.; Bessa, J.M.; Sousa, N.; Pinto, L.. "Cell genesis and dendritic plasticity: A neuroplastic pas de deux in the onset and remission from depression". Molecular Psychiatry 18 7 (2013): 748-750. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879409713&partnerID=MN8TOARS.
    10.1038/mp.2013.56
  22. Pinheiro, António Mateus; Pinto, Luísa; Bessa, J. M.; Morais, Mónica; Alves, N. D.; Monteiro, S.; Patrício, P.; Almeida, O. F. X.; Sousa, Nuno. "Sustained remission from depressive-like behavior depends on hippocampal neurogenesis". (2013): http://hdl.handle.net/1822/24154.
    10.1038/tp.2012.141
  23. Pinheiro, António Mateus; Patrício, P.; Bessa, J. M.; Sousa, Nuno; Pinto, Luísa. "Cell genesis and dendritic plasticity: a neuroplastic pas de deux in the onset and remission from depression". (2013): http://hdl.handle.net/1822/25059.
    10.1038/mp.2013.56
  24. Patrício, P.; Pinheiro, António Mateus; Sousa, Nuno; Pinto, Luísa. "Re-cycling paradigms : cell cycle regulation in adult hippocampal neurogenesis and implications for depression". (2013): http://hdl.handle.net/1822/25183.
  25. Patrício, P.; Pinheiro, António Mateus; Sousa, Nuno; Pinto, Luísa. "Re-cycling paradigms : cell cycle regulation in adult hippocampal neurogenesis and implications for depression". (2013): http://hdl.handle.net/1822/24200.
    10.1007/s12035-013-8422-x
  26. Pinto, L.; Mateus-Pinheiro, A.; Morais, M.; Bessa, J.M.; Sousa, N.. "Immuno-golgi as a tool for analyzing neuronal 3D-dendritic structure in phenotypically characterized neurons". PLoS ONE 7 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84858052488&partnerID=MN8TOARS.
    10.1371/journal.pone.0033114
  27. Pinto, Luísa; Pinheiro, António Mateus; Morais, Mónica; Bessa, J. M.; Sousa, Nuno. "Immuno-Golgi as a tool for analyzing neuronal 3D-dendritic structure in phenotypically characterized neurons". (2012): http://hdl.handle.net/1822/20448.
    10.1371/journal.pone.0033114
  28. Mateus-Pinheiro, A.; Pinto, L.; Sousa, N.. "Epigenetic (de)regulation of adult hippocampal neurogenesis: Implications for depression". Clinical Epigenetics 3 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880921625&partnerID=MN8TOARS.
    10.1186/1868-7083-3-5
  29. Pinheiro, António Mateus; Pinto, Luísa; Sousa, Nuno. "Epigenetic (de)regulation of adult hippocampal neurogenesis : implications for depression". (2011): http://hdl.handle.net/1822/18686.
    10.1186/1868-7083-3-5
Thesis / Dissertation
  1. Pinheiro, António Mateus. "Adult hippocampal neural plasticity: insights into its functional relevance in the stressed and depressed brain". PhD, 2016. http://hdl.handle.net/1822/43060.

Other

Other output
  1. AP2¿: a new player on adult hippocampal neurogenesis regulation. Since the recognition that the mammalian brain retains the ability to generate newborn neurons with functional relevance throughout life, the matrix of molecular regulators that govern adult neurogenesis has been the focus of much interest. In a recent study published in Molecular Psychiatry, we demonstrate Activating Protein 2¿ (AP2¿), a transcription factor previously implicated in cell fate det. 2018. Pinheiro, António Maria Restolho Mateus; Alves, Nuno Dinis Lopes Oliveira; Sousa, Nuno; Pinto, Luísa. http://hdl.handle.net/1822/57907.
    10.1177/1179069518766897
Distinctions

Other distinction

2015 Society for Neuroscience Student Grant Award, Society for Neuroscience (SFN) 
2014 EpiGeneSys: Collaborative international project grant, Epigenesys Study of hippocampal methylation and hydroxymethylation in animal model of depression
2013 Best “Fire-Talk” - Oral Communication Award in Sociedade Portuguesa de Neurociências
Sociedade Portuguesa de Neurociências, Portugal
2013 Best “Fire-Talk” - Oral Communication Award in Sociedade Portuguesa de Neurociências
Sociedade Portuguesa de Neurociências, Portugal
2013 Award for the year's Young Entrepreneur
2011 Award for the best Spinoff business project
2009 Award for the student with the Highest Grade the Applied Biology Course
Universidade do Minho, Portugal
2007 Award for the student with the highest Grade in 1st year class of the Applied Biology Course
Universidade do Minho, Portugal
2005 Award for the student with the Highest Grade of the D.Sancho II Highschool
2004 Award for the student with the Highest Grade of the D.Sancho II Highschool