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Diogo do Espírito Santo Nogueira completed his MSc in Biological Engineering from Instituto Superior Técnico (IST) in 2016, and a PhD in Bioengineering - Cell Therapies and Regenerative Medicine from IST in 2021. Since 2021, he is a Researcher at the Stem Cell Engineering Research Group (SCERG) of the Institute for Bioengineering and Biosciences (iBB), working with Vertical-Wheel bioreactors for expansion and cardiac differentiation of human pluripotent stem cells and on cellular agriculture of seafood, and, since 2024, an Invited Adjunt Professor at Instituto Superior de Engenharia de Lisboa (ISEL). He is also responsible for the social networks of the Department of Bioengineering of IST, SCERG and CellAgri Portugal - the Portuguese Association for Cellular Agriculture Development, as well as the maintenance of the SCERG website and the development, design and maintenance of the CellAgri Portugal website. Diogo is an author in 12 articles and 4 book chapters, with a total of 260 citations and an h-index of 9 (source: Research Gate), and has collaborated in 4 FCT-funded projects, covering different areas such as stem cell bioprocessing, bioprocess economic modelling, artificial intelligence/machine learning, computational fluid dynamics, decellularisation and electrical stimulation.
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Identification

Personal identification

Full name
Diogo do Espírito Santo Nogueira
Date of birth
1993/09/05
Gender
Male

Citation names

  • Nogueira, Diogo E.S.
  • Nogueira, Diogo

Author identifiers

Ciência ID
971A-C754-1C77
ORCID iD
0000-0003-2346-8485

Email addresses

  • diogoespiritosantonogueira@tecnico.ulisboa.pt (Professional)
  • diogo.nogueira@isel.pt (Professional)

Telephones

Telephone
  • 210407053 (Professional)

Addresses

  • Instituto Superior Técnico - Institute for Bioengineering and Biosciences. Av. Prof. Doutor Cavaco Silva, 2744-016, Porto Salvo, Oeiras, Portugal (Professional)
  • Instituto Superior de Engenharia de Lisboa, Rua Conselheiro Emídio Navarro, 1, 1959-007, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Engineering and Technology - Industrial Biotechnology - Bioprocessing Technologies

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2017/02/07 - 2021/07/08
Concluded
 Bioengenharia (Doutoramento)
Major in Bioengenharia - Terapias Celulares e Medicina Regenerativa
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Engineering Characterisation of Bioreactors for Human Pluripotent Stem Cell Expansion and Cardiac Differentiation" (THESIS/DISSERTATION)
 Pass with Distinction
2017/02/07 - 2018/02/02
Concluded
 Bioengenharia (Curso de doutoramento (conclusão de unidades curriculares))
Major in Bioengenharia - Terapias Celulares e Medicina Regenerativa
Universidade de Lisboa Instituto Superior Técnico, Portugal
 18/20
2011/09/20 - 2016/09/21
Concluded
 Engenharia Biológica (Mestrado integrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Derivation, characterization and purification of multipotent cardiovascular progenitor cells derived from human induced pluripotent stem cells" (THESIS/DISSERTATION)
 18/20
Affiliation

Science

Category
Host institution 		Employer
2021/09/01 - Current Researcher (Research) Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2016/11/28 - 2017/01/31 Research Assistant (Research) Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2024/03/01 - Current Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
Projects

Contract

Designation Funders
2022/01/01 - 2024/12/31 Analyzing NeuroIMmune dysregulation in Alzheimer´s disease toward a Therapy with miRNA-loaded Exosomes
PTDC/MED-NEU/2382/2021
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/02/01 - 2024/01/31 New technologies for Stem cell Manufacturing bioprocess monitoring and ARTificial intelligence-based modeling
PTDC/EQU-EQU/3853/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Instituto de Telecomunicações, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2022/09/30 Organoid Engineering for Production of 3D Cardiovascular Microtissues from Human Induced Pluripotent Stem Cells for Cardiotoxicity Assays
PTDC/EMD-TLM/29728/2017
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/10/01 - 2022/09/30 Upscaling the Production of Human Pluripotent Stem Cell-derived Cardiomyocytes using Vertical-Wheel Bioreactors
PTDC/EQU-EQU/29653/2017
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/02/01 - 2021/01/31 Engineering characterization of bioreactors for human pluripotent stem cell expansion and cardiac differentiation
PD/BD/128376/2017
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Institute for Bioengineering and Biosciences
UID/BIO/04565/2019
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Salvador, William O.S.; Nogueira, Diogo E.S.; Bovolato, ALC; Ferreira, FC; Cabral, JMS; Rodrigues, Carlos A.V.. "Bringing Cellular Agriculture to the Table: The Role of Animal Cell Bioreactors". In Cellular Agriculture: Technical and Scientific Foundations, edited by Evan Fraser; David Kaplan; Lenore Newman; Rickey Yada. 2023.
    Accepted
  2. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Cabral, Joaquim. "Emerging strategies for scalable human induced pluripotent stem cell expansion and differentiation". In Methods in iPSC Technology, edited by Birbrair, Alexander, 163-185. Elsevier, 2021.
    Published • 10.1016/b978-0-323-85766-6.00014-0
  3. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. Corresponding author: Rodrigues, Carlos A.V.. "Suspension Culture of Human Induced Pluripotent Stem Cells in Single-Use Vertical-WheelTM Bioreactors Using Aggregate and Microcarrier Culture Systems". In Stem Cells and Good Manufacturing Practices, edited by Turksen, Kursad, 167-178. Springer US, 2020.
    Accepted • 10.1007/7651_2020_287
  4. Rodrigues, Carlos A.V.; Branco, Mariana A.; Nogueira, Diogo E.S.; Silva, Teresa P.; Gomes, Ana Rita; Diogo, Maria Margarida; Cabral, Joaquim. "Bioreactors for Human Pluripotent Stem Cell Expansion and Differentiation". In Bioreactors for Stem Cell Expansion and Differentiation, edited by Joaquim M.S. Cabral; da Silva CL, 25-45. CRC Press, 2018.
    10.1201/9780429453144-2
Conference abstract
  1. Fábio F. F. Garrudo; Resina, Leonor; Nogueira, Diogo; Rodrigues, Carlos A.V.; Alemán, Carlos; Joaquim M.S. Cabral; Frederico Castelo Ferreira; Morgado, Jorge. Corresponding author: Fábio F. F. Garrudo. "Highly electroconductive PEDOT:PSS platforms for electrical stimulation studies of neural-differentiating iPSCs". Paper presented in ACS Fall 2023, San Francisco, 2023.
    Under revision
  2. Fábio Filipe Ferreira Garrudo; Nogueira, Diogo E.S.; Resina, Leonor; Alemán, Carlos; Cabral, Joaquim; Linhardt, Robert J.; Ferreira, Frederico; Morgado, Jorge. "Electrical stimulation positively interferes on induced pluripotent stem cell neural differentiation at different stages". Paper presented in TERMIS-EU Chapter Meeting 2023, Manchester, 2023.
  3. Nogueira, Diogo E.S.; Salvador, William O.S.; Neto, Pedro M.; Hashimura, Yas; Jung, Sunghoon; Bruno Pedras; Palmeira, Tiago; et al. "Engineering Characterisation of Vertical-WheelTM Bioreactors for Human Pluripotent Stem Cell Expansion and Cardiac Differentiation". Paper presented in TERMIS-EU Chapter Meeting 2023, Manchester, 2023.
  4. Fábio Filipe Ferreira Garrudo; Silva, João C.; Rodrigues, Carlos A.V.; Meneses, João; Moura, Carla; Nogueira, Diogo E.S.; Carvalho, Marta S.; et al. "Electroconductive platforms for the electrical stimulation of stem cells - an approach to the design of artificial human tissue microenvironments.". Paper presented in Polymer Connect 2022, Rome, 2022.
  5. Nogueira, Diogo E.S.; Salvador, William O.S.; Neto, Pedro M.; Hashimura, Yas; Jung, Sunghoon; Bruno Pedras; Palmeira, Tiago; et al. "Engineering Characterisation of Vertical-WheelTM Bioreactors for Human Pluripotent Stem Cell Expansion and Cardiac Differentiation". Paper presented in 2nd iBB Workshop, Lisbon, 2022.
  6. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Salvador, William O.S.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Development of a High-Density System for the Expansion of Human Induced Pluripotent Stem Cells as Aggregates in Single-Use Vertical-WheelTM Bioreactors". Paper presented in International Conference on Advanced Research on Sustainability and Intelligent Manufacturing RESIM 2022, Marinha Grande, 2022.
  7. Salvador, William O.S.; Nogueira, Diogo E.S.; Ferreira, Frederico; Cabral, Joaquim; Rodrigues, Carlos A.V.. "A Novel Decision Support Tool for Optimally Designing Large Scale Stem Cell Expansion Bioprocesses". Paper presented in International Conference on Advanced Research on Sustainability and Intelligent Manufacturing RESIM 2022, Marinha Grande, 2022.
  8. Fábio Filipe Ferreira Garrudo; Mikael, Paiyz; Rodrigues, Carlos A.V.; Nogueira, Diogo E.S.; Silva, João C.; Udangawa Keating, Ranodhi N.; Ferreira, Flávio; et al. "New strategies in engineering polyaniline electrospun nanofibers for neural tissue engineering applications". Paper presented in 6th TERMIS World Congress, Maastricht, 2021.
  9. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Development of a High-Density System for Expansion and Cardiac Differentiation of Human Induced Pluripotent Stem Cells as Aggregates in Single-Use Vertical-WheelTM Bioreactors". Paper presented in 6th TERMIS World Congress, Maastricht, 2021.
  10. Fábio Filipe Ferreira Garrudo; Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Ferreira, Flávio; Cabral, Joaquim; Morgado, Jorge; Linhardt, Robert J.; Ferreira, Frederico. "Creating multifunctional platforms: electroconductive coaxial fibers to electrically stimulate differentiating neurons". Paper presented in 31st Conference of the European Society for Biomaterials, 2021.
  11. Fábio Filipe Ferreira Garrudo; Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Ferreira, Flávio; Chapman, Caitlyn A.; Hoffman, Pauline R.; Mikael, Paiyz; et al. "Design of an electroconductive and biodegradable coaxial-electrospun fiber for neural tissue engineering applications". Paper presented in Polymer Connect 2021, 2021.
  12. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Expansion and Cardiac Differentiation of Human Induced Pluripotent Stem Cells as Aggregates in Single-Use Vertical-WheelTM Bioreactors". Paper presented in 12th European Symposium on Biochemical Engineering Sciences, Portoroz, 2021.
  13. Rodrigues, Carlos A.V.; Nogueira, Diogo; Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia; Hashimura, Y.; Jung, S.; et al. "Human Induced Pluripotent Stem Cell Culture in Vertical-Wheel Bioreactors". Paper presented in Virtual ESBES 2020, 2020.
    Published
  14. Fábio Filipe Ferreira Garrudo; Chapman, Caitlyn A.; Hoffman, Pauline R.; Udangawa, Ranodhi N.; Silva, João C.; Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; et al. "Harnessing electrical stimulation for neural stem cells culture using polyaniline-based coaxial electrospun fibers". Paper presented in TERMIS-EU Chapter Meeting 2020, Manchester, 2020.
  15. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Strategies for the Expansion of Human Induced Pluripotent Stem Cells as Aggregates in Single-Use Vertical-WheelTM Bioreactors.". Paper presented in TERMIS-EU Chapter Meeting 2020, Manchester, 2020.
  16. Fábio Filipe Ferreira Garrudo; Sousa, Miriam; Chapman, Caitlyn A.; Hoffman, Pauline R.; Udangawa, Ranodhi N.; Silva, João C.; Sordini, Laura; et al. "The dual role of electricity on scaffolds: preparation and applications". Paper presented in Polymer Connect 2020, Lisbon, 2020.
  17. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Human pluripotent stem cell expansion as aggregates in Vertical-WheelTM bioreactors". Paper presented in 257th National Meeting & Exposition of the American Chemical Society, Orlando, 2019.
  18. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Human pluripotent stem cell expansion as aggregates in Vertical-WheelTM Bioreactors". Paper presented in 12th Symposium of the European Society of Biochemical Engineering Sciences, Lisbon, 2017.
Conference poster
  1. Salvador, William O.S.; Nogueira, Diogo E.S.; Joaquim M.S. Cabral; Klaus Graumann; Rodrigues, Carlos A.V.. Corresponding author: Rodrigues, Carlos A.V.. "Human Induced Pluripotent Stem Cell Culture in Stirred-Tank Bioreactors: Optimization and Automation of Feeding Strategies for Achieving Economic Viability". Paper presented in BioManufacturing Without Borders 2024, 2024.
  2. Migueis Migueis; Lourenço, Maria; Garcia, Gonçalo; Ianni, Marta; Salvador, William; Nogueira, Diogo; Rodrigues C; et al. "Therapeutic Potential of hNPC-Exosomes Loaded with miR-124 when delivered to the 5xFAD Mouse Model of Alzheimer’s Disease". 2024.
  3. Migueis, Mafalda; Lourenço, Maria; Ianni, Marta; Nogueira, Diogo; Carlos Rodrigues; Costa-Coelho, Tiago; Garcia, Gonçalo; et al. "An Exosome-based Therapeutic Strategy targeting Neuroinflammation in Alzheimer’s Disease with miR-124". Paper presented in XXII National Congress of Biochemistry, 2024.
  4. Salvador, William O.S.; Nogueira, Diogo E.S.; Joaquim M.S. Cabral; Klaus Graumann; Rodrigues, Carlos A.V.. Corresponding author: Rodrigues, Carlos A.V.. "Stem Cell Culture in Stirred-Tank Bioreactors: Optimization and Automation of Feeding Strategies for Achieving Economic Viability". Paper presented in 2nd International Conference of the Portuguese Association for Cellular Agriculture, 2024.
  5. Corraliza-Gomez, Miriam; Ianni, Marta; Migueis, Mafalda; Nogueira, Diogo; Rodrigues, Carlos; Brites, Dora. "Large-Scale Production of Exosomes for miRNA Loading and delivery to Regenerate Neuron-Glia Homeostasis". Paper presented in VII Symposium Portuguese Glial Network, 2024.
  6. Salvador, William O.S.; Nogueira, Diogo E.S.; Ferreira, Frederico C.; Cabral, Joaquim M.S.; Rodrigues, Carlos A.V.. Corresponding author: Rodrigues, Carlos A.V.. "An Integrated Approach to the Production of Extracellular Vesicles from Human Induced Pluripotent Stem Cells in Stirred-Tank Bioreactors". Paper presented in 3rd iBB Workshop, 2023.
  7. Salvador, William O.S.; Nogueira, Diogo E.S.; Ferreira, Federico C.; Cabral, Joaquim M.S.; Rodrigues, Carlos A.V.. Corresponding author: Rodrigues, Carlos A.V.. "BEMSCA: A Novel Decision Support Tool for the Optimal Design of Large-Scale Stem Cell Expansion Bioprocesses". Paper presented in 1st CellAgri International Conference on Cellular Agriculture, 2023.
  8. Alves, Laura; Marques, Diana; Nogueira, Diogo E.S.; Salvador, William O.S.; Sanjuan-Alberte, Paola; Joaquim M.S. Cabral; Ferreira, Frederico; Duscher, Alexandrea ; Rodrigues, Carlos A.V.. Corresponding author: Rodrigues, Carlos A.V.. "Sea Bass Embryonic Cell Culture Using Microcarriers for Cultivated Seafood Production". Paper presented in 1st International Cellular Agriculture Conference, 2023.
  9. Salvador, William O.S.; Nogueira, Diogo E.S.; Ferreira, Frederico; Cabral, Joaquim; Rodrigues, Carlos A.V.. "BEMSCA: A Novel Decision Support Tool for Optimally Designing Large-Scale Stem Cell Expansion Bioprocesses". Paper presented in TERMIS-EU Chapter Meeting 2023, 2023.
  10. Fábio Filipe Ferreira Garrudo; João Carlos Silva; Rodrigues, Carlos A.V.; Nogueira, Diogo E.S.; Marcelino, Pedro; Gomes, Mariana R.; Barbosa, Frederico; et al. "Design of an artificial vertebrae - electroconductive platforms for the electrical stimulation of stem cells". Paper presented in 2nd iBB Workshop, 2022.
  11. Salvador, William O.S.; Nogueira, Diogo E.S.; Ferreira, Frederico; Cabral, Joaquim; Rodrigues, Carlos A.V.. "BEMSCA: A Novel Decision Support Tool for Optimally Designing Large-Scale Stem Cell Expansion Bioprocesses". Paper presented in 2nd iBB Workshop, 2022.
  12. Agostinho, Sofia P.; Branco, Mariana A.; Nogueira, Diogo E.S.; Diogo, Maria Margarida; Cabral, Joaquim; Fred, Ana; Rodrigues, Carlos A.V.. "Unsupervised machine learning for whole transcriptome analysis of pluripotent stem cells cardiac differentiation". Paper presented in 2nd iBB Workshop, 2022.
  13. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Salvador, William O.S.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Expansion and Cardiac Differentiation of Human Pluripotent Stem Cells as Aggregates in Vertical-WheelTM Bioreactors". Paper presented in 27th ESACT Meeting, 2022.
  14. Salvador, William O.S.; Nogueira, Diogo E.S.; Ferreira, Frederico; Cabral, Joaquim; Rodrigues, Carlos A.V.. "BEMSCA: A Novel Decision Support Tool for the Optimal Design of a Large-Scale Human Induced Pluripotent Stem Cell Expansion Bioprocess". Paper presented in 27th ESACT Meeting, 2022.
  15. Rodrigues, Carlos A.V.; Nogueira, Diogo E.S.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Expansion of Human Pluripotent Stem Cells as Aggregates in Vertical-WheelTM Bioreactors". Paper presented in TECHNOBEAT Pre X-Mas Symposium on iPS Based Cell Therapies – From Bench to Bedside, 2019.
  16. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Expansion of Human Pluripotent Stem Cells as Aggregates in Vertical-WheelTM Bioreactors". Paper presented in 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2019.
  17. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Expansion of Human Pluripotent Stem Cells as Aggregates in Vertical-WheelTM Bioreactors.". Paper presented in Encontro Ciência 2019, 2019.
  18. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Human pluripotent stem cell expansion as aggregates in Vertical-WheelTM bioreactors". Paper presented in PhD Open Days, 2019.
  19. Rodrigues, Carlos A.V.; Nogueira, Diogo E.S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Human pluripotent stem cell expansion as aggregates in Vertical-WheelTM bioreactors". Paper presented in Advancing Manufacture of Cell and Gene Therapies VI, 2019.
  20. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. "Human pluripotent stem cell expansion as aggregates in Vertical-WheelTM Bioreactors". Paper presented in Encontro Ciência 2018, 2018.
Journal article
  1. Agostinho, Sofia P.; Branco, Mariana A.; Nogueira, Diogo E.S.; Diogo, Maria Margarida; Joaquim M.S. Cabral; Rodrigues, Carlos A.V.. "Unsupervised Analysis of Whole Transcriptome Data from Human Pluripotent Stem Cells Cardiac Differentiation". Scientific Reports 14 1 (2024): http://dx.doi.org/10.1038/s41598-024-52970-z.
    Published
  2. Salvador, William O.S.; Nogueira, Diogo E.S.; Castelo Ferreira, Frederico; Cabral, Joaquim M.S.; Rodrigues, Carlos A.V.. Corresponding author: Rodrigues, Carlos A.V.. "BEMSCA: A novel decision support tool applied to the optimal design of a large-scale human induced pluripotent stem cell expansion bioprocess". Current Research in Biotechnology (2023): http://dx.doi.org/10.1016/j.crbiot.2023.100163.
    Published • 10.1016/j.crbiot.2023.100163
  3. Salvador, William O.S.; Ribeiro, Inês A.B.; Nogueira, Diogo E.S.; Ferreira, Frederico; Cabral, Joaquim; Rodrigues, Carlos A.V.. Corresponding author: Rodrigues, Carlos A.V.. "Bioprocess Economic Modeling: Decision Support Tools for the Development of Stem Cell Therapy Products". Bioengineering 9 12 (2022): 791. http://dx.doi.org/10.3390/bioengineering9120791.
    Open access • Published • 10.3390/bioengineering9120791
  4. Carvalho, Marta S.; Nogueira, Diogo E.S.; Cabral, Joaquim; Rodrigues, Carlos A.V.. Corresponding author: Carvalho, Marta S.. "Neural progenitor cell-derived extracellular matrix as a new platform for neural differentiation of human induced pluripotent stem cells". Biomaterials and Biosystems 8 (2022): 100070. http://dx.doi.org/10.1016/j.bbiosy.2022.100070.
    Open access • Published • 10.1016/j.bbiosy.2022.100070
  5. Neto, Pedro M.; Nogueira, Diogo E.S.; Hashimura, Yas; Jung, Sunghoon; Bruno Pedras; Berberan-Santos, Mário; Palmeira, Tiago; et al. Corresponding author: Rodrigues, Carlos A.V.. "Characterization of the Aeration and Hydrodynamics in Vertical-WheelTM Bioreactors". Bioengineering 9 8 (2022): 386. http://dx.doi.org/10.3390/bioengineering9080386.
    Open access • Published • 10.3390/bioengineering9080386
  6. Nogueira, Diogo E.S.; Cabral, Joaquim; Rodrigues, Carlos A.V.. Corresponding author: Rodrigues, Carlos A.V.. "Single-Use Bioreactors for Human Pluripotent and Adult Stem Cells: Towards Regenerative Medicine Applications". Bioengineering 8 5 (2021): 68. http://dx.doi.org/10.3390/bioengineering8050068.
    Open access • Published • 10.3390/bioengineering8050068
  7. Fábio F. F. Garrudo; Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Ferreira, Flávio; Paradiso, Patrizia; Colaço, Rogério; Marques, Ana C.; et al. Corresponding author: Ferreira, Frederico. "Electrical stimulation of neural-differentiating iPSCs on novel coaxial electroconductive nanofibers". Biomaterials Science 9 15 (2021): 5359-5382. http://dx.doi.org/10.1039/d1bm00503k.
    Published • 10.1039/d1bm00503k
  8. Pushp, Pallavi; Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Ferreira, Frederico; Cabral, Joaquim; Gupta, Mukesh Kumar. Corresponding author: Cabral, Joaquim. "A Concise Review on Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Personalized Regenerative Medicine". Stem Cell Reviews and Reports 17 3 (2020): 748-776. http://dx.doi.org/10.1007/s12015-020-10061-2.
    Published • 10.1007/s12015-020-10061-2
  9. Silva, Teresa P.; Fernandes, Tiago G.; Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Bekman, Evguenia P.; Hashimura, Yas; Jung, Sunghoon; et al. "Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by Immunostaining". Journal of Visualized Experiments 160 (2020): http://dx.doi.org/10.3791/61143.
    Published • 10.3791/61143
  10. Nogueira, Diogo E.S.; Rodrigues, Carlos A.V.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim. Corresponding author: Rodrigues, Carlos A.V.. "Strategies for the expansion of human induced pluripotent stem cells as aggregates in single-use Vertical-WheelTM bioreactors". Journal of Biological Engineering 13 1 (2019): http://dx.doi.org/10.1186/s13036-019-0204-1.
    Open access • Published • 10.1186/s13036-019-0204-1
  11. Rodrigues, Carlos A.V.; Nogueira, Diogo E.S.; Cabral, Joaquim. Corresponding author: Rodrigues, Carlos A.V.. "Next-Generation Stem Cell Expansion Technologies". Cell and Gene Therapy Insights 4 8 (2018): 791-804. http://dx.doi.org/10.18609/cgti.2018.076.
    Open access • Published • 10.18609/cgti.2018.076
  12. Rodrigues, Carlos A.V.; Silva, Teresa P.; Nogueira, Diogo E.S.; Fernandes, Tiago G.; Hashimura, Yas; Wesselschmidt, Robin; Diogo, Maria Margarida; Lee, Brian; Cabral, Joaquim. Corresponding author: Rodrigues, Carlos A.V.. "Scalable culture of human induced pluripotent cells on microcarriers under xeno-free conditions using single-use vertical-wheelTM bioreactors". Journal of Chemical Technology & Biotechnology 93 12 (2018): 3597-3606. http://dx.doi.org/10.1002/jctb.5738.
    10.1002/jctb.5738
Thesis / Dissertation
  1. "Engineering Characterisation of Bioreactors for Human Pluripotent Stem Cell Expansion and Cardiac Differentiation". PhD, Universidade de Lisboa Instituto Superior Técnico, 2021.
  2. Nogueira, Diogo E.S.. "Derivation, characterization and purification of multipotent cardiovascular progenitor cells derived from human induced pluripotent stem cells". Master, Universidade de Lisboa Instituto Superior Técnico, 2016. https://fenix.tecnico.ulisboa.pt/cursos/mebiol/dissertacao/1972678479053180.
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/01/01 - 2024/10/05 2nd International Conference of the Portuguese Association for Cellular Agriculture (2024/10/04 - 2024/10/05)
Conference (Member of the Organising Committee)
 CellAgri Portugal - Associação Portuguesa para o Desenvolvimento da Agricultura Celular, Portugal
2023/01/01 - 2023/09/08 1st International Conference of the Portuguese Association for Cellular Agriculture (2023/09/07 - 2023/09/08)
Conference (Member of the Organising Committee)
 CellAgri Portugal - Associação Portuguesa para o Desenvolvimento da Agricultura Celular, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/12/09 Optimization of In Vitro Models for an Improved In Vitro to In Vivo Extrapolation of Hepatically Cleared Drugs
(Thesis) Main arguer
 Catarina Isabel de Mira Couquinha (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/11/17 Development of Stem Cell-Derived Islets as a Regenerative Cell Replacement Therapy for Type 1 Diabetes. Pancreatic Polypeptide cells: A missing component in stem cell-derived islets
(Thesis) Main arguer
 Ana Matilde Matias Silvano (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Association member

Society Organization name Role
2022/06 - Current CellAgri Portugal - Portuguese Association for Cellular Agriculture Development
2019 - Current Portuguese Society for Stem Cells and Cell Therapies

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/09/16 - 2025/02/15 Microbiology Engenharia Química e Biológica (Licenciatura) Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2024/09/16 - 2025/02/15 Biology and Histology Engenharia Biomédica (Licenciatura) Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2024/09/16 - 2025/02/15 Advanced Medical Therapies Engenharia Biomédica (Licenciatura) Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2024/02/19 - 2024/07/27 Biochemistry Engenharia Química e Biológica (Licenciatura) Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2024/02/19 - 2024/07/27 Biochemistry B Engenharia Biomédica (Licenciatura) Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2024/02/19 - 2024/07/27 Seminars in Biomedical Engineering Engenharia Biomédica (Licenciatura) Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2024/02/19 - 2024/07/27 Seminars II Engenharia Biomédica (Mestrado) Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2024/02/19 - 2024/07/27 Cell and Tissue Engineering Engenharia Biomédica (Mestrado) Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
Distinctions

Award

2022 Best Oral Presentation
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2018 Merit Scholarship 2014/2015
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 Academic Merit Diploma 2015/2016
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 Academic Excellence Diploma 2014/2015
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 Academic Merit Diploma 2013/2014
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 Merit Scholarship 2011/2012
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 Academic Merit Diploma 2012/2013
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 Academic Merit Diploma 2011/2012
Universidade de Lisboa Instituto Superior Técnico, Portugal