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João Luís Oliveira Durães finished his Master's degree in Medicine by the Faculty of Medicine of the University of Coimbra in 07/2013. He is currently doing his PhD in Health Sciences in the Faculty of Medicine of the University of Coimbra, in the field of Chronobiology and Neurodegenerative Dementias. He completed his Neurology Residency in the Centro Hospitalar e Universitário de Coimbra EPE, where he is currently a Neurology Consultant. He is a member of the Investigation Consortium CIBB (Center for Innovative Biomedicine and Biotechnology) from the University of Coimbra. He currently works mainly in the fields of Dementia, Neurogenetics and Inborn Errors of Metabolism. He collaborated in 3 externally funded Investigation Projects. He published 22 articles in international scientific journals. He was an invited reviewer for 3 articles in international scientific journals and abstract reviewer in National and International Congresses. He had 10 oral presentations as invited speaker in Scientific meetings and Postgraduate courses. He organized 1 international Scientific meeting and 4 courses in the field of Neurology. He was a thesis advisor for 2 MSc in Medicine students. He received 6 prizes, including the João Lobo Antunes 2020 Prize from the Santa Casa da Misericórdia de Lisboa (40000 euros). He is currently a member of the Working Group for beta-oxidation diseases of the Portuguese Society for Metabolic Disorders.
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Identification

Personal identification

Full name
João Luís Oliveira Durães

Citation names

  • Durães, João

Author identifiers

Ciência ID
981B-A9BD-BE35
ORCID iD
0000-0001-9671-593X

Email addresses

  • 11038@chuc.min-saude.pt (Professional)

Telephones

Mobile phone
  • 918082696 (Personal)

Websites

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Clinical Neurology
  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Elementary (A2) Intermediate (B1) Elementary (A2) Intermediate (B1) Beginner (A1)
Spanish; Castilian Elementary (A2) Intermediate (B1) Elementary (A2) Intermediate (B1) Beginner (A1)
Italian Beginner (A1) Elementary (A2) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2018/09/15 - 2023/07/15
Ongoing
 PhD in Health Sciences (Doutoramento)
Major in Neurosciences
Universidade de Coimbra Faculdade de Medicina, Portugal
2007/09/15 - 2013/07/15
Concluded
 MSc in Medicine (Mestrado integrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
"Neurobiologia na recaída : cocaína e heroína" (THESIS/DISSERTATION)
 16
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2021/09 - Current Invited Assistant (University Teacher) Universidade de Coimbra Faculdade de Medicina, Portugal

Other Careers

Category
Host institution 		Employer
2021/09 - Current Assistente (Médica) Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2015/01/02 - 2020/10/23 Interno (Médica) Centro Hospitalar e Universitário de Coimbra EPE, Portugal
Projects

Grant

Designation Funders
2021 - Current Non-invasive biomarkers of brain AD pathology at pre-dementia stages
EXPL/MEC-NEU/0192/2021
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Ongoing
2020/12 - Current Impact of sleep deprivation on circadian clock function mediated by neurons and glial cells
2020.04499.BD.
PD/BD/135497/2018
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020 - Current Disease modelling of frontotemporal dementia in human brain organoids
PTDC/MEC-NEU/4814/2020
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing

Contract

Designation Funders
2023 - Current The Genetic Frontotemporal dementia Initiative
doi.org/10.1002/alz.063252
Researcher
Ongoing
2022/01/01 - 2023/06/30 Marcadores não invasivos de patologia DA cerebral antes da demência
10.54499/EXPL/MEC-NEU/0192/2021
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Durães, João. "Neurodegeneration and muscular involvement in intermediate autosomal recessive CLCN7-related Osteopetrosis: an atypical presentation". Paper presented in 71st annual meeting of the American Academy of Neurology, Filadélfia, 2019.
    Published
  2. Durães, João. "Late-onset multiple acyl-CoA dehydrogenase deficiency with a complex genetic finding". Paper presented in 71st annual meeting of the American Academy of Neurology, Filadélfia, 2019.
    Published
  3. Durães, João. "Brief cognitive evaluation in adult-onset leukodystrophies". Paper presented in SSIEM annual symposium 2019, Roterdão, 2019.
    Published
  4. Durães, João. "MicroRNAs of endothelial progenitor cells associated with improved recovery mechanisms in acute ischemic stroke". Paper presented in 5th European Stroke Organization conference, Milão, 2019.
    Published
  5. Durães, João. "C-reactive protein as a predictor of mild cognitive impairment conversion into Alzheimer’s disease". Paper presented in 5th congress of the European Academy of Neurology, Oslo, 2019.
    Published
  6. Durães, João. "Functional genomics' studies are mandatory for clarifying pathogenicity of novel genetic variants detected by NGS in OXPHOS disorders". Paper presented in 51st European Society of Human Genetics conference, Milão, 2019.
    Published
  7. Durães, João. "Cerebral creatine deficiency syndromes: a single-centre experience from diagnosis to treatment". Paper presented in 4th congress of the European Academy of Neurology, Lisboa, 2018.
    Published
  8. Durães, João. "Neuropsychiatric symptoms in variants of Primary Progressive Aphasia". Paper presented in 4th congress of the European Academy of Neurology, Lisboa, 2018.
    Published
  9. Durães, João. "An atypical presentation of Argininossuccinic aciduria". Paper presented in 3rd congress of the European Academy of Neurology, Amesterdão, 2017.
    Published
  10. Durães, João. "Alkaline phosphatase and functional outcome in stroke patients submitted to intravenous fibrinolysis". Paper presented in 3rd European Stroke Organization conference, Praga, 2017.
    Published
  11. Durães, João. "Acute measles encephalitis with an atypical clinical presentation in a vaccinated adult". Paper presented in 3rd congress of the European Academy of Neurology, Amesterdão, 2017.
    Published
  12. Durães, João. "Quality of life in adult Portuguese patients with mitochondrial diseases: initial validation of an assessment instrument". Paper presented in 13th international congress on Inborn Errors of Metabolism, Rio de Janeiro, 2017.
    Published
  13. Durães, João. "Quality of life in adult patients with leukodystrophies: the impact of perceived fatigue". Paper presented in 13th international congress on Inborn Errors of Metabolism, Rio de Janeiro, 2017.
    Published
  14. Durães, João. "ApoE genotype and the outcome of thrombolysis in acute ischemic stroke". Paper presented in 3rd congress of the European Academy of Neurology, Amesterdão, 2017.
    Published
  15. Hassan, Eman; Magdy, Nermen. "Late-onset Krabbe disease in an adult metabolic disorders consultation". Paper presented in 2nd congress of the European Academy of Neurology, Copenhaga, 2016.
    Published
  16. Durães, João. "Clinical presentation and molecular genetic testing in Spinocerebellar ataxia type 17". Paper presented in 2nd congress of the European Academy of Neurology, Copenhaga, 2016.
    Published
Journal article
  1. Cristiana Silva; João Durães; Marisa Lima; Daniela Jardim Pereira; Isabel Santana; Maria Rosário Almeida. "Towards a neurocognitive profile in familial cerebral cavernous malformations". Acta Neurologica Belgica (2024): https://doi.org/10.1007/s13760-023-02314-x.
    10.1007/s13760-023-02314-x
  2. Maria Rosário Almeida; Miguel Tábuas-Pereira; Inês Baldeiras; Marisa Lima; João Durães; João Massano; Madalena Pinto; Catarina Cruto; Isabel Santana. "Characterization of Progranulin Gene Mutations in Portuguese Patients with Frontotemporal Dementia". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms25010511.
    10.3390/ijms25010511
  3. Bernardes, Catarina; Lima, Marisa; Duro, Diana; Silva-Spínola, Anuschka; Durães, João; Tábuas-Pereira, Miguel; Baldeiras, Inês; Freitas, Sandra; Santana, Isabel. "Montreal Cognitive Assessment in Mild Cognitive Impairment: Relationship with Cerebrospinal Fluid Biomarkers and Conversion to Dementia". Journal of Alzheimer's Disease 96 3 (2023): 1173-1182. http://dx.doi.org/10.3233/jad-230916.
    10.3233/jad-230916
  4. Bateman, Randall J.; Smith, Janice; Donohue, Michael C.; Delmar, Paul; Abbas, Rachid; Salloway, Stephen; Wojtowicz, Jakub; et al. "Two Phase 3 Trials of Gantenerumab in Early Alzheimer’s Disease". New England Journal of Medicine 389 20 (2023): 1862-1876. http://dx.doi.org/10.1056/nejmoa2304430.
    10.1056/nejmoa2304430
  5. Ullgren, Abbe; Öijerstedt, Linn; Olofsson, Jennie; Bergström, Sofia; Remnestål, Julia; van Swieten, John C.; Jiskoot, Lize C.; et al. "Altered plasma protein profiles in genetic FTD – a GENFI study". Molecular Neurodegeneration 18 1 (2023): http://dx.doi.org/10.1186/s13024-023-00677-6.
    10.1186/s13024-023-00677-6
  6. Veronese, Nicola; Soysal, Pinar; Demurtas, Jacopo; Solmi, Marco; Bruyère, Olivier; Christodoulou, Nikos; Ramalho, Rodrigo; et al. "Physical activity and exercise for the prevention and management of mild cognitive impairment and dementia: a collaborative international guideline". European Geriatric Medicine 14 5 (2023): 925-952. http://dx.doi.org/10.1007/s41999-023-00858-y.
    10.1007/s41999-023-00858-y
  7. Lopes das Neves, Pedro; Durães, João; Silva-Spinola, Anuschka; Lima, Marisa; Leitão, Maria João; Tábuas-Pereira, Miguel; Santana, Isabel; Baldeiras, Inês. "Serum Neurofilament Light Chain in the Diagnostic Evaluation of Patients with Cognitive Symptoms in the Neurological Consultation of a Tertiary Center". Journal of Alzheimer's Disease 95 2 (2023): 391-397. http://dx.doi.org/10.3233/jad-221208.
    10.3233/jad-221208
  8. Anuschka Silva-Spínola; Marisa Lima; Maria João Leitão; Catarina Bernardes; João Durães; Diana Duro; Miguel Tábuas-Pereira; Isabel Santana; Inês Baldeiras. "Blood biomarkers in mild cognitive impairment patients: Relationship between analytes and progression to Alzheimer disease dementia". European Journal of Neurology (2023): https://doi.org/10.1111/ene.15762.
    10.1111/ene.15762
  9. Benzoni, Chiara; Moscatelli, Marco; Farina, Laura; Magri, Stefania; Ciano, Claudia; Scaioli, Vidmer; Alverà, Sara; et al. "Adult-onset leukodystrophy with vanishing white matter: a case series of 19 patients". Journal of Neurology 270 9 (2023): 4219-4234. http://dx.doi.org/10.1007/s00415-023-11762-7.
    10.1007/s00415-023-11762-7
  10. Sobral-Pinho, André; Jorge, André; Fonseca, Pedro; Sargento-Freitas, João; Durães, João; Martins, Ana Inês; Macário, Maria Carmo; Lemos, João. "Sequential and combined central retinal artery occlusion and anterior ischemic optic neuropathy in Fabry’s disease". Journal of Neurology 270 8 (2023): 4103-4106. http://dx.doi.org/10.1007/s00415-023-11734-x.
    10.1007/s00415-023-11734-x
  11. Klockgether, Thomas; Synofzik, Matthis; Alhusaini, Saud; Anheim, Mathieu; Antonijevic, Irina; Ashizawa, Tee; Bataller, Luis; et al. "Consensus Recommendations for Clinical Outcome Assessments and Registry Development in Ataxias: Ataxia Global Initiative (AGI) Working Group Expert Guidance". The Cerebellum (2023): http://dx.doi.org/10.1007/s12311-023-01547-z.
    10.1007/s12311-023-01547-z
  12. Lima, Marisa; Tábuas-Pereira, Miguel; Durães, João; Vieira, Daniela; Faustino, Pedro; Baldeiras, Inês; Santana, Isabel. "Neuropsychological Assessment in the Distinction Between Biomarker Defined Frontal-Variant of Alzheimer’s Disease and Behavioral-Variant of Frontotemporal Dementia". Journal of Alzheimer's Disease 91 4 (2023): 1303-1312. http://dx.doi.org/10.3233/jad-220897.
    10.3233/jad-220897
  13. Pérez-Millan, Agnès; Borrego-Écija, Sergi; van Swieten, John C.; Jiskoot, Lize; Moreno, Fermin; Laforce, Robert; Graff, Caroline; et al. "Loss of brainstem white matter predicts onset and motor neuron symptoms in C9orf72 expansion carriers: a GENFI study". Journal of Neurology 270 3 (2022): 1573-1586. http://dx.doi.org/10.1007/s00415-022-11435-x.
    10.1007/s00415-022-11435-x
  14. Baldeiras, Inês; Silva-Spínola, Anuschka; Lima, Marisa; Leitão, Maria João; Durães, João; Vieira, Daniela; Tbuas-Pereira, Miguel; et al. "Alzheimer’s Disease Diagnosis Based on the Amyloid, Tau, and Neurodegeneration Scheme (ATN) in a Real-Life Multicenter Cohort of General Neurological Centers". Journal of Alzheimer's Disease (2022): 1-14. http://dx.doi.org/10.3233/jad-220587.
    10.3233/jad-220587
  15. Santos, Ernestina; Moura, João; Samões, Raquel; Sousa, Ana Paula; Mendonça, Teresa; Abreu, Pedro; Guimarães, Joana; et al. "Late onset neuromyelitis optica spectrum disorders (LONMOSD) from a nationwide Portuguese study: Anti-AQP4 positive, anti-MOG positive and seronegative subgroups". (2022):
    10.1016/j.msard.2022.103845
  16. Tábuas-Pereira, Miguel; Durães, João; Beato-Coelho, José; Rita Nogueira, Ana; Duro, Diana; Baldeiras, Inês; Santana, Isabel. "Lewy body dementia is associated with an increased risk of atrial fibrillation: A case-control study". Journal of Clinical Neuroscience 99 (2022): 62-65. http://dx.doi.org/10.1016/j.jocn.2022.02.038.
    Published • 10.1016/j.jocn.2022.02.038
  17. Miguel Tábuas-Pereira; Isabel Santana; Maria Rosário Almeida; João Durães; Marisa Lima; Diana Duro; Célia Kun-Rodrigues; Jose Bras; Rita Guerreiro. "Rare variants in TP73 in a frontotemporal dementia cohort link this gene with primary progressive aphasia phenotypes". European Journal of Neurology (2022): https://doi.org/10.1111/ene.15248.
    10.1111/ene.15248
  18. Lima, Marisa; Tábuas-Pereira, Miguel; Durães, João; Faustino, Pedro; Simões, Mário R.; Kukull, Walter; Knopman, David S.; Santana, Isabel. "Portuguese version of the CDR plus NACC FTLD: Validation studies". Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 14 1 (2022): http://dx.doi.org/10.1002/dad2.12355.
    10.1002/dad2.12355
  19. Durães, João. "Neuromyelitis optica spectrum disorders: A nationwide Portuguese clinical epidemiological study". Multiple Sclerosis and Related Disorders (2021): http://dx.doi.org/10.1016/j.msard.2021.103258.
    10.1016/j.msard.2021.103258
  20. Anuschka Silva-Spínola; Marisa Lima; Maria João Leitão; João Durães; Miguel Tábuas-Pereira; Maria Rosário Almeida; Isabel Santana; Inês Baldeiras. "Serum neurofilament light chain as a surrogate of cognitive decline in sporadic and familial Frontotemporal dementia". European Journal of Neurology (2021): https://doi.org/10.1111/ene.15058.
    10.1111/ene.15058
  21. Fernandes, Catarina. "Pediatric Multiple Sclerosis Before the PARADIGMS Study: Nine Years of Experience in a Portuguese Tertiary Center". Sinapse 21 1 (2021): 33-39. http://dx.doi.org/10.46531/sinapse/ao/200062/2021.
    Published • 10.46531/sinapse/ao/200062/2021
  22. Durães, João. "Neuropsychological features of progranulin-associated frontotemporal dementia: a nested case-control study". Neural Regeneration Research 16 5 (2021): 910-910. http://dx.doi.org/10.4103/1673-5374.297082.
    10.4103/1673-5374.297082
  23. Fernandes, Andreia; Tábuas-Pereira, Miguel; Duro, Diana; Lima, Marisa; Gens, Helena; Santiago, Beatriz; Durães, João; et al. "C-reactive protein as a predictor of mild cognitive impairment conversion into Alzheimer's disease dementia". Experimental Gerontology 138 (2020): 111004. http://dx.doi.org/10.1016/j.exger.2020.111004.
    10.1016/j.exger.2020.111004
  24. Durães, João. "Patients with progranulin mutations overlap with the progressive dysexecutive syndrome: towards the definition of a frontoparietal dementia phenotype". Brain Communications 2 2 (2020): http://dx.doi.org/10.1093/braincomms/fcaa126.
    10.1093/braincomms/fcaa126
  25. Pereira, Miguel; Durães, João; Macário, Maria do Carmo. "Two sisters with myoclonus and ataxia". Practical Neurology (2020): practneurol-2019. http://dx.doi.org/10.1136/practneurol-2019-002446.
    10.1136/practneurol-2019-002446
  26. João Durães; Ettore Salsano; Maria do Carmo Macário. "Adult-onset Krabbe disease". Neurology: Clinical Practice (2019): https://doi.org/10.1212/CPJ.0000000000000780.
    10.1212/CPJ.0000000000000780
  27. Durães, João. "Lower CSF Amyloid-Beta1–42 Predicts a Higher Mortality Rate in Frontotemporal Dementia". Diagnostics (2019): http://dx.doi.org/10.3390/diagnostics9040162.
    10.3390/diagnostics9040162
  28. Durães, João. "Increased CSF tau is associated with a higher risk of seizures in patients with Alzheimer's disease". Epilepsy & Behavior (2019): http://dx.doi.org/10.1016/j.yebeh.2019.06.033.
    10.1016/j.yebeh.2019.06.033
  29. João Durães; Inês Coutinho; Angelina Mariano; Argemiro Geraldo; Maria Carmo Macário. "Demyelinating disease of the central nervous system associated with Pembrolizumab treatment for metastatic melanoma". Multiple Sclerosis Journal 25 7 (2019): 1005-1008. https://doi.org/10.1177/1352458518803724.
    10.1177/1352458518803724
  30. João Durães; Margarida Gonçalo; Lívia Sousa; Maria Carmo Macário. "Hypocomplementemic urticarial vasculitis and multiple Sclerosis: A rare association or an atypical presentation?". Multiple Sclerosis and Related Disorders 30 (2019): 244-246. https://doi.org/10.1016/j.msard.2019.02.020.
    10.1016/j.msard.2019.02.020
  31. Durães, João. "Increased risk of melanoma in C9ORF72 repeat expansion carriers: A case-control study". Muscle & Nerve (2019): http://dx.doi.org/10.1002/mus.26383.
    10.1002/mus.26383
  32. Marques, P.; Beato-Coelho, J.; Durães, J.; Geraldo, A.. "Ischaemic stroke as the initial manifestation of systemic amyloidosis". BMJ Case Reports 12 6 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068440997&partnerID=MN8TOARS.
    10.1136/bcr-2018-228979
  33. Louro, P.; Durães, J.; Oliveira, D.; Paiva, S.; Ramos, L.; Macário, M.C.. "Woodhouse–Sakati Syndrome: First report of a Portuguese case". American Journal of Medical Genetics, Part A (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070263996&partnerID=MN8TOARS.
    10.1002/ajmg.a.61303
  34. Cousyn, L.; Law-Ye, B.; Pyatigorskaya, N.; Debs, R.; Froissart, R.; Piraud, M.; Federico, A.; et al. "Brain MRI features and scoring of leukodystrophy in adult-onset Krabbe disease". Neurology 93 7 (2019): e647-e652. http://www.scopus.com/inward/record.url?eid=2-s2.0-85071355600&partnerID=MN8TOARS.
    10.1212/WNL.0000000000007943
  35. João Durães; Miguel Tábuas-Pereira; Rui Araújo; Diana Duro; Inês Baldeiras; Beatriz Santiago; Isabel Santana. "The Head Turning Sign in Dementia and Mild Cognitive Impairment: Its Relationship to Cognition, Behavior, and Cerebrospinal Fluid Biomarkers". Dementia and Geriatric Cognitive Disorders 46 1-2 (2018): 42-49. https://doi.org/10.1159%2F000486531.
    10.1159/000486531
  36. Bacalhau M; Simões M; Rocha MC; Hardy SA; Vincent AE; Durães J; Macário MC; et al. "Disclosing the functional changes of two genetic alterations in a patient with Chronic Progressive External Ophthalmoplegia: Report of the novel mtDNA m.7486G>A variant.". Neuromuscular disorders : NMD (2017): http://europepmc.org/abstract/med/29398297.
    10.1016/j.nmd.2017.11.006
  37. Gabriel AJ; Almeida MR; Ribeiro MH; Durães J; Tábuas-Pereira M; Pinheiro AC; Pascoal R; Santana I; Baldeiras I. "Association between butyrylcholinesterase and cerebrospinal fluid biomarkers in Alzheimer's disease patients.". Neuroscience letters (2017): http://europepmc.org/abstract/med/28108398.
    10.1016/j.neulet.2017.01.036
  38. Tomás J; Durães J; Lacerda L; Macário MC. "Adolescent-onset Krabbe disease with an initial diagnosis of multiple sclerosis and a novel mutation.". BMJ case reports (2015): http://europepmc.org/abstract/med/26396125.
    10.1136/bcr-2015-210625
Thesis / Dissertation
  1. Durães, João. "Neurobiologia na recaída: cocaína e heroína". Master, Universidade de Coimbra Faculdade de Medicina, 2013.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01 Clinical aspects of polyglutamine-expansion disorders' PhD Programme in Health Sciences
Universidade de Coimbra - Faculdade de Medicina (Portugal)
2023/06 Desafios da co-patologia: Doença de Corpos de Lewy e Doença de Alzheimer 37ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
Grupo de Estudos de Envelhecimento Cerebral e Demência (Portugal)
2021/10/08 Neuropathology and Neurodegeneration Biomarkers in Mucopolysaccharidosis MPS 360
Centro de Referência para Doenças Hereditárias do Metabolismo do Centro Hospitalar São João (Porto, Portugal)
2021/07 Dementias Masters in Palliative Care
Faculty of Medicine of the University of Coimbra (Coimbra, Portugal)
2021/07 Circadian rhythm disruption: a target for personalized intervention in neurodegenerative dementias 35a Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Portugal)
2021/06 Organic Acidurias SPDM Spring Meeting
Sociedade Portuguesa Doenças Metabólicas (Portugal)
2021/04/07 Clinical diagnosis in Prion Diseases Mestrado em Neurociências Molecular e de Translação
Faculty of Medicine of the University of Coimbra (Coimbra, Portugal)
2020/11 Alterações da substância branca nas Doenças Hereditárias do Metabolismo Curso Doenças Neurometabólicas - Doenças raras / Sintomas Comuns
Sociedade Portuguesa de Neurologia (Portugal)
2020/11 Neuropsychological features of progranulin-associated frontotemporal dementia: a nested case-control study Congresso de Neurologia 2020
Sociedade Portuguesa de Neurologia
2020/11 Autonomic dysfunction in frontotemporal lobar degeneration: clinical and MRI analysis Congresso de Neurologia 2020
Sociedade Portuguesa de Neurologia (Portugal)
2020/05 Blood-brain barrier dysfunction in Alzheimer’s disease is different in female and male patients 6th Congress of European Academy of Neurology
European Academy of Neurology
2019/12 Doenças hereditárias do metabolismo e doença neurológica no adulto XV Curso Básico de Doenças Hereditárias do Metabolismo
Centro Hospitalar e Universitário de Coimbra (Coimbra, Portugal)
2019/11 Doença do Espectro da Neuromielite Óptica: Registo Multicêntrico Nacional Congresso da Sociedade Portuguesa de Neurologia
Sociedade Portuguesa de Neurologia (Coimbra, Portugal)
2019/11 Encefalite auto-imune: análise dos biomarcadores de patologia degenerativa no LCR Congresso da Sociedade Portuguesa de Neurologia
Sociedade Portuguesa de Neurologia (Coimbra, Portugal)
2019/11 Variáveis de LCR predictoras de Pib-PET positivo Congresso da Sociedade Portuguesa de Neurologia
Sociedade Portuguesa de Neurologia (Coimbra, Portugal)
2019/11 Relação dos biomarcadores de LCR de doença de Alzheimer com distúrbios do sono numa população portuguesa 33ª reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
Grupo de Estudos de Envelhecimento Cerebral e Demência (Cúria, Portugal)
2019/11 Behavioral Variant Frontotemporal Dementia: gender differences in neuropsychiatric symptoms 33ª reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
Grupo de Estudos de Envelhecimento Cerebral e Demência (Cúria, Portugal)
2019/11 Alterações iónicas na Doença de Alzheimer: um estudo exploratório 33ª reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
Grupo de Estudos de Envelhecimento Cerebral e Demência (Cúria, Portugal)
2019/06 Envolvimento do sistema nervoso central nas Doenças Mitocondriais Curso Doenças mitocondriais: uma abordagem multidisciplinar
Sociedade Portuguesa de Doenças Metabólicas (Lisboa, Portugal)
2019/06 Brief cognitive assessment in late-onset Pompe disease British Inherited Metabolic Disorders Group conference
British Inherited Metabolic Disorders Group (Cambridge, United Kingdom)
2019/05 Recognizing Cerebrotendinous Xanthomatosis, X-linked Adrenoleukodystrophy and Niemann-Pick disease type C in an adult patient Neurology Pan-London Calman Teaching Programme
National Hospital for Neurology and Neurosurgery (Londres, United Kingdom)
2019/04 Manifestações Neuropsiquiátricas de Doenças Hereditárias do Metabolismo Curso Red flags em Doenças Hereditárias do Metabolismo
Sociedade Portuguesa de Doenças Metabólicas (Porto, Portugal)
2019/03 Brain magnetic resonance imaging findings in Chronic Progressive External Ophthalmoplegia 15th international symposium of the SPDM
Sociedade Portuguesa de Doenças Metabólicas (Coimbra, Portugal)
2019/03 Mitochondrial protein import genes involvement in Leber’s hereditary optic neuropathy 15th international symposium of the SPDM
Sociedade Portuguesa de Doenças Metabólicas (Coimbra, Portugal)
2019/03 Cerebrospinal fluid Neurofilament light chain levels in Frontotemporal Lobar Degeneration: genetic and phenotypic associations 14th international conference on Alzheimer’s & Parkinson’s Diseases
Kenes Group (Lisboa, Portugal)
2019/02 Cerebrospinal fluid neurofilaments as a tool for the discrimination of Frontotemporal Lobar Degeneration subtypes 2nd meeting of the Society for CSF Analysis and Clinical Neurochemistry
Society for CSF analysis and clinical neurochemistry (Amesterdão, Netherlands)
2019/02 Esclerose múltipla de início em idade pediátrica: 8 anos de experiência num centro terciário 13º congresso da Sociedade Portuguesa de Neuropediatria
Sociedade Portuguesa de Neuropediatria (Coimbra, Portugal)
2018/11 Estudo histológico de músculo na doença mitocondrial em adultos: a sua importância na abordagem diagnóstica inicial Congresso de Neurologia
Sociedade Portuguesa de Neurologia (Porto, Portugal)
2018/11 Heterogeneidade de manifestações clínicas na doença de Gaucher e opções terapêuticas Congresso da Sociedade Portuguesa de Neurologia
Sociedade Portuguesa de Neurologia (Porto, Portugal)
2018/05 Cefaleia hemicrânia contínua secundária Reunião de primavera
Sociedade Portuguesa de Cefaleias (Fátima, Portugal)
2018/04 Condições e tipos de colheitas processamento, armazenamento e transporte de produtos biológicos. Colheitas SOS Curso Apresentações Neurológicas de Doenças Metabólicas
Sociedade Portuguesa de Doenças Metabólicas (Coimbra, Portugal)
2017/12 Rituximab in Multiple Sclerosis: importance of the dosing regimen 25th annual meeting of the European Charcot Foundation
European Charcot Foundation (Baveno, Italy)
2017/11 Lewy Body dementia is associated with an increased risk of atrial fibrillation Congresso da Sociedade Portuguesa de Neurologia
Sociedade Portuguesa de Neurologia (Lisboa, Portugal)
2017/11 Aß40 aumenta a capacidade diagnóstica dos biomarcadores de LCR em doentes com hidrocefalia de pressão normal 31ª reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
Grupo de Estudos de Envelhecimento Cerebral e Demência (Lisboa, Portugal)
2017/10 Avaliação da correlação entre fatores cognitivos e comportamentais e biomarcadores de LCR na variante comportamental da demência frontotemporal 31ª reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
Grupo de Estudos de Envelhecimento Cerebral e Demência (Lisboa, Portugal)
2017/05 Scheie syndrome: diagnosis after cardioembolic stroke Mucopolysaccharidosis masterclass
Biomarin (Dubai, United Arab Emirates)
2017/05 Fármacos modificadores da doença na Esclerose Múltipla pediátrica: a experiência dos CHUC Reunião de primavera-verão do Grupo de Estudos de Esclerose Múltipla
Grupo de Estudos de Esclerose Múltipla (Figueira da Foz, Portugal)
2017/03 Brain function in Mucopolysaccharidosis patients Satellite Symposium - 13th International Symposium of the SPDM
Biomarin (Évora, Portugal)
2017/03 Phenotypic heterogeneity with variable Parkinsonism in Gaucher disease 13th international symposium of the SPDM
Sociedade Portuguesa de Doenças Metabólicas (Évora, Portugal)
2017/03 Mild presentation of fragile X-associated tremor/ataxia syndrome in a female premutation carrier 4th International Porto Congress of Multiple Sclerosis
Centro Hospitalar de São João (Porto, Portugal)
2017/03 Quality of life in adult patients with mitochondrial diseases 13th international symposium of the SPDM
Sociedade Portuguesa de Doenças Metabólicas (Évora, Portugal)
2017/03 Leigh Syndrome – Clinical and neuroimagiological correlation in four cases 13th international symposium of the SPDM
Sociedade Portuguesa de Doenças Metabólicas (Évora, Portugal)
2017/03 Late-onset Pompe disease: functional assessment and rehabilitation 13th international symposium of the SPDM
Sociedade Portuguesa de Doenças Metabólicas (Évora, Portugal)
2016/05 Progressão na variante comportamental na Demência Frontotemporal: um papel para os biomarcadores de LCR? Fórum da Sociedade Portuguesa de Neurologia
Sociedade Portuguesa de Neurologia (Leiria, Portugal)
2016/05 Doença do espectro DFT-DNM associada a mutações patogénicas Fórum da Sociedade Portuguesa de Neurologia
Sociedade Portuguesa de Neurologia (Leiria, Portugal)
2016/05 Terapêutica com anticolinesterásicos – Avaliação de benefício sintomático na Doença de Alzheimer Fórum da Sociedade Portuguesa de Neurologia
Sociedade Portuguesa de Neurologia (Leiria, Portugal)
2016/05 Distúrbio do sono REM na fase pré-clínica da Demência com Corpos de Lewy 30ª reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
Grupo de Estudos de Envelhecimento Cerebral e Demência (Leiria, Portugal)
2016/03 Clinical presentation and predictors of outcome in adult patients with mitochondrial diseases 10th world congress on controversies in neurology
Comtecmed (Lisboa, Portugal)
2015/05 Avaliação fenotípica de portadores e famílias com mutações no gene da progranulina no espectro da Degenerescência Lobar Fronto-Temporal Fórum da Sociedade Portuguesa de Neurologia
Sociedade Portuguesa de Neurologia (Aveiro, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/10 - Current Quality of life in Hereditary Spastic Paraplegia: demographic and clinical determinants
Supervisor
 Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2023/10 - 2023/10 Utilidade da GFAP e NfL séricos na Demência com Corpos de Lewy
Co-supervisor
 Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2021 - 2022 Clinical Validation of Cognitive Fluctuation Screening Instruments for the Portuguese Population with Dementia
Co-supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2019 - 2019 Pediatric multiple sclerosis: descriptive analysis of a Demyelinating Disorders Consultation
Co-supervisor
 Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2017 Behavioral Symptoms in the Variants of Primary Progressive Aphasia
Co-supervisor
 Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/11 - Current Curso Neurologic Presentation of Metabolic Disorders (2023/11)
Congress (Co-organisor)
 Sociedade Portuguesa de Neurologia, Portugal
2023/03 - Current 19.º Simpósio Internacional da Sociedade Portuguesa de Doenças Metabólicas (2023/03)
Symposium (Member of the Organising Committee)
 Sociedade Portuguesa de Doenças Metabólicas, Portugal
2020/11 - Current Member of the Organizing Committee - Sintomas comuns/Doenças raras Course (2020/11)
Congress (Member of the Organising Committee)
 Sociedade Portuguesa de Neurologia, Portugal
2019/03 - Current Organization of the '15th International Symposium of the SPDM (2019/03)
Symposium (Member of the Organising Committee)
 Sociedade Portuguesa de Doenças Metabólicas, Portugal
2021/06 - 2021/06 Member of the Organizing Committee - SPDM Spring Meeting (2021/06 - 2021/06)
Congress (Member of the Scientific Committee)
 Sociedade Portuguesa de Doenças Metabólicas, Portugal

Association member

Society Organization name Role
2020/01 - Current Biomarkers in Neuropsychiatric disorders: from molecules to diagnosis and intervention - Consórcio CIBB (Center for Innovative Biomedicine and Biotechnology), Universidade de Coimbra PhD Student

Committee member

Activity description
Role 		Institution / Organization
2022 - Current Member of Management Group for the EAN Coordinating Panel on Rare Neurological Diseases
Member
 European Academy of Neurology, Austria
2021/06 - Current Member of the National Working Group - Fatty Acid Beta-Oxidation Disorders
Member
 Sociedade Portuguesa de Doenças Metabólicas, Portugal
2020 - Current Secretary of the General Assembly for the Sociedade Portuguesa de Doenças Metabólicas
Other
 Sociedade Portuguesa de Doenças Metabólicas, Portugal
2019 - Current Sub-investigator in the clinical trial: GRADUATE II: Safety and Efficacy Study of Gantenerumab in Participants With Early Alzheimer's Disease [ROCHE]
Member
 Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2018 - Current Sub-investigator in the clinical trial: MARS: A Multicenter, Multinational, Observational Morquio A Registry Study [BIOMARIN]
Member
 Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2017 - Current Sub-investigator in the clinical trial: Pompe Disease Registry [Sanofi Genzyme]
Member
 Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2017 - Current Sub-investigator in the clinical trial: Mucopolysaccharidosis type 1 Disease Registry [Sanofi Genzyme]
Member
 Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2019 - 2021/12 Portuguese Representative of the Resident and Research Fellow Section
Other
 European Academy of Neurology, Austria
2018 - 2021/12 Member of the Comissão Organizadora da Comissão de Internos e Recém-Especialistas em Neurologia
Member
 Sociedade Portuguesa de Neurologia, Portugal
2017 - 2021/12 Member of Management Group for the Scientific Panel Dementia and cognitive disorders
Coordinator
 European Academy of Neurology, Austria
2019 - 2020 Expanded Disability Status Scale Rater in the clinical trial: OPTIMUM: Oral Ponesimod versus Teriflunomide in Relapsing Multiple Sclerosis [ACTELION]
Member
 Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2018 - 2019 Sub-investigator in the clinical trial: CREAD: A study of Crenezumab versus Placebo to evaluate the efficacy and safety in participants with prodromal to mild Alzheimer¿s Disease [ROCHE]
Member
 Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2017 - 2019 Expanded Disability Status Scale Rater in the clinical trial: ASCLEPIOS: Efficacy and safety of Ofatumumab compared to Teriflunomide in patients with relapsing Multiple Sclerosis [NOVARTIS]
Member
 Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2017 - 2019 Expanded Disability Status Scale Rater in the clinical trial: DAYBREAK: A Multi-Site, Open-Label Extension Trial of Oral RPC1063 in Relapsing Multiple Sclerosis [CELGENE]
Member
 Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2017 - 2019 Expanded Disability Status Scale Rater in the clinical trial: ENSEMBLE: Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Participants With Early Stage Relapsing Remitting Multiple Sclerosis [ROCHE]
Member
 Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2017 - 2019 Expanded Disability Status Scale Rater in the clinical trial: ORATORIO: A study of Ocrelizumab in patients with Primary Progressive Multiple Sclerosis [ROCHE]
Member
 Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2016 - 2019 Sub-investigator in the clinical trial: ENGAGE: 221AD301 Phase 3 study of Aducanumab (BIIB037) in early Alzheimer¿s Disease [BIOGEN]
Member
 Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2017 - 2018 Sub-investigator in the clinical trial: DAYBREAK-ALZ: A Study of Lanabecestat (LY3314814) in participants with mild Alzheimer's Disease dementia [Eli Lilly and Company]
Member
 Centro Hospitalar e Universitário de Coimbra EPE, Portugal

Conference scientific committee

Conference name Conference host
2022/02 - 2022/02 Abstract reviewer - 8th Congress of the European Academy of Neurology
2021/11 - 2021/11 Abstract reviewer - Congresso de Neurologia 2021, Portuguese Neurological Society
2020/11 - 2020/11 Chairperson - Expanding the concept of neurometabolic disorders Session, 16th International Symposium of the Portuguese Society for Metabolic Disorders
2019 - 2019 Chairperson, Poster Presentation Session - 15th International Symposium of the SPDM Coimbra, Portugal
2018 - 2018 Abstract reviewer - 4th Congress of the European Academy of Neurology Lisboa, Portugal

Interview (tv / radio show)

Program Topic
2020/12 - 2020/12 Razão de Ser

Journal scientific committee

Journal title (ISSN) Publisher
2022/02 - 2022/02 Acta Neurologica Belgica
2020 - 2020 Neurology: Clinical Practice (2163-0402) Wolters Kluwer
2019 - 2019 Translational Neurodegeneration (2047-9158) Springer (Biomed Central Ltd.)
Distinctions

Award

2023 Prize "Orlando Leitão"
Sociedade Portuguesa de Neurologia, Portugal
2021 Prize for Best Oral Presentation
Grupo de Estudos de Envelhecimento Cerebral e Demência, Portugal
2020 Prize João Lobo Antunes
Santa Casa da Misericórdia de Lisboa, Portugal
2019 Prize "Orlando Leitão"
Sociedade Portuguesa de Neurologia, Portugal
2019 Prize for the best poster communication - 15th International SPDM Symposium
Sociedade Portuguesa de Doenças Metabólicas, Portugal
2017 Clinical Fellowship Grant
Sociedade Portuguesa de Doenças Metabólicas, Portugal
2016 Prize "António Flores"
Sociedade Portuguesa de Neurologia, Portugal
2013 Prize to the 3% best students of the year 2012/2013
Universidade de Coimbra Faculdade de Medicina, Portugal