Curriculum Vitae
Maria Margarida de Carvalho Negrão Serra
Identification
Personal identification
- Full name
- Maria Margarida de Carvalho Negrão Serra
Citation names
- Serra, Maria
- Margarida Serra
Author identifiers
- Ciência ID
- 9917-961C-3B73
- ORCID iD
- 0000-0001-5013-6625
Telephones
- Mobile phone
-
- 915 680 64 (Professional)
Websites
Knowledge fields
- Engineering and Technology
Languages
| Language | Speaking | Reading | Writing | Listening | Peer-review |
|---|---|---|---|---|---|
| English | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) | |
| French | Intermediate (B1) | Advanced (C1) | Intermediate (B1) | Intermediate (B1) |
Education
| Degree | Classification | |
|---|---|---|
|
2008/01/01 - 2011/02/11
Concluded
|
Doutoramento em Engenharia e Ciências da Tecnologia (Doutoramento)
Major in Engenharia Biomédica
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Process Engineering of Stem Cells for Clinical Application" (THESIS/DISSERTATION)
|
Aprovado |
|
2003
Concluded
|
Biological Engineering (Licenciatura)
Universidade de Lisboa, Portugal
"not applicable" (THESIS/DISSERTATION)
|
15 valores |
|
1998
Concluded
|
Ensino Secundario (Ensino secundário)
Escola Secundária nº2 da Portela, Portugal
|
18 valores |
Affiliation
Science
| Category Host institution |
Employer | |
|---|---|---|
| 2018/01/01 - Current | Principal Investigator (Research) | Instituto de Biologia Experimental e Tecnológica, Portugal |
| iNOVA4Health, Portugal | ||
| 2015 - 2017 | Auxiliary Researcher (Research) | iNOVA4Health, Portugal |
| 2011/02/01 - 2015/11/01 | Auxiliary Researcher (Research) | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2011/01 - 2011/01 | Auxiliary Researcher (Research) | Instituto de Biologia Experimental e Tecnológica, Portugal |
| Instituto de Biologia Experimental e Tecnológica, Portugal | ||
| 2004/02/02 - 2007/12/31 | Research Assistant (Research) | Intituto de Biologia Experimental e Tecnológica, Portugal |
Teaching in Higher Education
| Category Host institution |
Employer | |
|---|---|---|
| 2019/10 - Current | Invited Assistant Professor (University Teacher) | Universidade Nova de Lisboa, Portugal |
| Universidade Nova de Lisboa - Faculdade de Ciências e Tecnologia, Portugal |
Others
| Category Host institution |
Employer | |
|---|---|---|
| 2018/11/01 - Current | Head of Stem Cell Bioengineering Lab | Instituto de Biologia Experimental e Tecnológica, Portugal |
| Instituto de Biologia Experimental e Tecnológica, Portugal | ||
| 2014/01/01 - Current | Lecturer, PhD Program in Molecular Biosciences, ITQB-UNL, Portugal. | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2014 - Current | Coordinator of the Curricular Core Unit “Stem Cell Engineering” (6 ECTS) from PhD Program Bioengineering of Cell Therapies and Regenerative Medicine | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2014 - Current | Coordinator of the Curricular Core Unit “Advanced Therapy Medicinal Products-ATMP” (1.5 ECT) of the ITQB NOVA PhD Program in Molecular Biosciences | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2014 - Current | Biotechnology Master (FCT NOVA) – lecture on “Stem Cell Engineering for Cell Therapy” in Animal Cell Biotechnology Course | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2014 - Current | Biochemistry for Health Master (ITQB NOVA and FCT NOVA) Lectures on Stem Cell Engineering for Cell Therapy in the Biopharmaceuticals course | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2014 - Current | Invited to lectures on Stem Cells Bioengineering and Cell Therapies in Master Programs at Universidade do Algarve and Faculdade de Ciências da Universidade de Lisboa | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2012 - Current | Invited to lectures on Stem Cells Bioengineering, ATMP and Cell Therapies Manufacturing in PhD Programs at Universidade de Coimbra (CNC PhD program at Centro de Neurociencias e Biologia Celular, FCUL | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2017/01/01 - 2018/10/31 | Senior Scientist (Stem Cell Bioprocessing and Cell Therapy) | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2014 - 2018 | Lecturer of the MIT-Portugal PhD Program, Bioengineering Program | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2008/01/01 - 2011/02/11 | Ph.D. student | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2011/01/17 - 2011/01/21 | Visiting Posdoc Researcher Training and Technology Transfer- Culture and characterization of human mesenchymal stem cells (hMSCs) for clinical application - Apceth, Munich, Germany (SME Cell Therapy) | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2010/04/25 - 2010/04/30 | Visiting PhD Student Training - Expansion and differentiation of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPS) into cardiomyocytes. | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2007 - 2010 | PhD Student | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2009/04/20 - 2009/05/01 | Visiting PhD Student Training - Culture, differentiaton and characterization of human neural precursor stem cells - University of Leipzig, Leipzig, Germany | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2006/05/22 - 2006/05/25 | Visiting PhD Student Training - Human embryonic stem cells culture and characterization-Cellartis AB; Göteborg, Sweden | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2005/04/06 - 2005/05/21 | Visiting PhD Student Training - Culture and differentiation of adult pancreatic stem cells - Fraunhofer Institut for Biomedical Engineering IBMT; St Ingbert, Germany | Instituto de Biologia Experimental e Tecnológica, Portugal |
| 2003/02/03 - 2003/09/30 | Trainee | Universidade de Lisboa Faculdade de Medicina, Portugal |
Projects
Grant
| Designation | Funders | |
|---|---|---|
| 2017/04 - 2024/03 | Implementation of The Discoveries Centre for Regenerative and Precision Medicine, a new Centre of Excellence in Portugal
Researcher
|
European Commission |
| 2011/02 - 2016/04 | New Models for Preclinical Evaluation of Drug Efficacy in Common Solid Tumours | European Commission |
| 2013/07 - 2015/12 | Integrative approaches to depict human cardiac stem cell receptome and its role in the cardiac regenerative process | Fundação para a Ciência e a Tecnologia |
| 2010/04 - 2015/09 | CARDIO REPAIR EUROPEAN MULTIDISCIPLINARY INITIATIVE | European Commission |
| 2011/07 - 2014/12 | Verbundprojekt: Stem cell generation and manipulation by nanoparticle mediated gene transfer for the safe clinical application of gene-modified cells (NanoGene) - Teilvorhaben: In-vitro-Testung DNA-Vektor beladener nanopartikulärer Formulierungen zur virusfreien Transfektion | Bundesministerium fur Bildung und Forschung Dienststelle Bonn |
| 2012/11 - 2014/10 | Specialised Cell Carrier Components | European Commission |
| 2013/07 - 2014/09 | Development of a scalable strategy for stem cells purification | Fundação para a Ciência e a Tecnologia |
| 2011/03 - 2014/08 | 3D in vitro models for reducing animal experimentation in pharmaceutical development: integrative approaches for prediction of hepatic drug metabolism and neurotoxicity | Fundação para a Ciência e a Tecnologia |
| 2008/10 - 2013/03 | NONHUMAN ADENOVIRUS VECTORS FOR GENE TRANSFER TO THE BRAIN
Researcher
|
European Commission
Concluded
|
| 2009/09 - 2012/08 | High yield and performance stem cell lab | European Commission |
| 2009/01 - 2011/12 | Integrated strategy for expansion, neuronal differentiation and cryopreservation of human embryonic stem cells | Fundação para a Ciência e a Tecnologia |
| 2006/04 - 2011/10 | European network for the advancement of clinical gene transfer and therapy | European Commission |
| 2004/03 - 2008/02 | CellPROM - Cell Programming by Nanoscaled Devices | European Commission |
Contract
| Designation | Funders | |
|---|---|---|
| 2020/04/01 - Current | Advancing the Manufacturing of Adipose Tissue Stem Cells for Allogeneic Cell Therapy
n.a.
Principal investigator
|
Ongoing
|
| 2016/01 - Current | Understanding primary hyperoxaluria type 1 towards the development of innovative therapeutic strategies
Principal investigator
|
Deutsche Forschungsgemeinschaft
Concluded
|
| 2024/01/01 - 2027/12/31 | Orgestra- Organoid technologies for disease modelling, drug discovery and development for rare diseases.
Supervisor
Instituto de Biologia Experimental e Tecnológica, Portugal
|
European Commission Marie Sklodowska-Curie Actions
Ongoing
|
| 2022/10/11 - 2026/10/10 | GENERATION OF HUMAN INDUCED PLURIPOTENT STEM CELLS FROM HAPLO-SELECTED CORD BLOOD SAMPLES (HAPLO-iPS)
Co-Principal Investigator (Co-PI)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
European Cooperation in Science and Technology
Ongoing
|
| 2023/05/01 - 2026/04/30 | CARxAll- Next generation, off-the-shelf CD1a/CCR9-directed CAR immunotherapy for relapse/refractory T-cell acute lymphoblastic
leukemia - Investigador Principal do iBET
101113067
Researcher
Instituto de Biologia Experimental e Tecnológica, Portugal
|
European Commission
Ongoing
|
| 2023/01/01 - 2025/12/31 | EXCELERATE: Advancing the manufacturing of EXtracellular vesicles derived from human pluripotent stem CELls for cardiac rEgeneRATive
medicine
2022.10467.PTDC
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
| 2023/01/01 - 2025/12/31 | Advancing the Manufacturing of Adipose Tissue Stem Cells for Allogeneic Cell Therapy II - Investigador responsável
not applicable
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Ongoing
|
| 2022/10/01 - 2025/09/30 | GENERATION OF HUMAN INDUCED PLURIPOTENT STEM CELLS FROM HAPLO-SELECTED CORD BLOOD SAMPLES - co-leader of Working Group
CA21151
Researcher
|
European Commission
Ongoing
|
| 2022/01/01 - 2024/12/31 | VOOmics- OMICs approaches to reveal the anticancer properties of Virgin Olive Oil
PTDC/BAA-AGR/4732/2021
Researcher
|
|
| 2020/01/01 - 2024/12/31 | BRAV3: COMPUTATIONAL BIOMECHANICS AND BIOENGINEERING 3D PRINTING TO DEVELOP A PERSONALISED REGENERATIVE BIOLOGICAL VENTRICULAR
ASSIST DEVICE TO PROVIDE LASTING FUNCTIONAL SUPPORT TO DAMAGED HEARTS - Investigador Responsável da equipa iBET
874827
Researcher
Instituto de Biologia Experimental e Tecnológica, Portugal
|
EU Framework Programme for Research and Innovation Euratom
Ongoing
|
| 2023/03/01 - 2024/08/31 | CARTool- A process engineering approach for manufacturing CAR T cells in biOreactOrs with improved cLinical revelance
2022.07312.PTDC
Researcher
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
| 2020/09/01 - 2023/04/30 | CardioPatch: Network of Excellence for the development of Advanced Therapies for the treatment of Myocardial Infarction based
on Regenerative Medicine and 3D printing.
SOE4/P1/E1063
Principal investigator
|
Margarida Serra
Ongoing
|
| 2018/10/01 - 2021/09/30 | NeoCoronary: Role of CCBE1 during coronary vasculature development and neo-angiogenesis upon myocardial infarction, through
stimulation of VEGF-C signaling
02/SAICT/2017/029590
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
| 2018/09/01 - 2021/08/31 | PEFPlateletValue: Pulsed Electric Fields for valorization of platelets with no therapeutic value into a high biomedical potential
product
PTDC/BTM-ORG/32187/2017
Researcher
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
| 2018/04/01 - 2021/03/31 | MetaCardio: Metabolic signatures of human pluripotent stem cells derived cardiomyocytes for improved cell therapy
02/SAICT/2017/032566
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
| 2016/12/01 - 2020/11/30 | Novos alvos na insuficiência cardíaca diastólica: das comorbilidades à medicina personalizada
SAICTPAC/0047/2015
Instituto Nacional de Engenharia Biomédica, Portugal
Universidade de Aveiro, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal Universidade NOVA de Lisboa NOVA Medical School, Portugal Universidade do Porto Faculdade de Medicina, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal |
Fundação para a Ciência e a Tecnologia
Ongoing
|
| 2018/04/01 - 2020/10/31 | DYNAMO: Elucidating the engineering principles in small-scale bioreactor systems for rational process intensification
iBETXplore- DYNAMO
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Instituto de Biologia Experimental e Tecnológica
Ongoing
|
| 2016/11/01 - 2020/10/31 | NETDIAMOND: New targets in diastolic heart failure: from comorbidities to personalized medicine
POCI-01-0145-FEDER-016385
Researcher
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Associação para a Inovação e Desenvolvimento da FCT
Ongoing
|
| 2018/10/01 - 2019/12/31 | CARDIOCONTRACT: Automated Cardiomyocyte Contractility Assay Instrument
12529/19/Q
Principal investigator
|
Eurostars
Concluded
|
| 2018/09/01 - 2019/12/31 | A friend with many faces: molecular aspects of cardiopulmonary bypass during cardiac surgery
Proj ID: 201707-05-46 ; LISBOA-01-0145-FEDER-007344
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2014/12/01 - 2018/05/31 | CARDIOSTEM: Tecidos cardíacos e terapias baseadas em células estaminais para aplicações cardiovasculares
MITP-TB/ECE/0013/2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Unidade Local de Saúde São José EPE, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal |
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2015/01 - 2017/12 | CardioRegen: Integrative studies from the embryo to Scalable Multipronged Generation of hESC-derived Myocardial progenitors
for heart repair
Researcher
|
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2014/12 - 2017/11 | CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications
Researcher
|
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2016/01/01 - 2016/12/31 | Characterization of Receptome of human Mesenchymal Stem Cells
Contract Research Project
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Concluded
|
| 2015/01/01 - 2015/12/31 | Up-scaling of hiPSC expansion process using stirred tank bioreactors
Contract Research Project
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Concluded
|
| 2013/07/01 - 2015/12/31 | Estratégias integradas para decifrar o receptoma de células estaminais cardiacas humanas e o seu papel no processo de regeneração
cardíaca
PTDC/BBB-BIO/1414/2012
Instituto de Biologia Experimental e Tecnológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal |
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2014/01/01 - 2014/12/31 | Expansion of human Cancer Stem Cells in stirred-tank bioreactors
Contract Research Project
Researcher
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Concluded
|
| 2013/01/01 - 2014/12/31 | Development of bioprocesses for human Mesenchymal Stem Cells for Cell Therapy applications; Part 2 – Downstream processing
of hMSCs & Scale-up
Contract Reseach Project
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Concluded
|
| 2011/07/01 - 2014/12/31 | Desenvolvimento e manipulação de células estaminais usando a tecnologia de transferência génica mediada por nanopartículas
para aplicação clínica de células modificadas geneticamente.
ENMED/0001/2010
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2013/01/01 - 2013/12/31 | Development of bioprocesses for expansion of human Mesenchymal Stem Cells in disposable bioreactors
Contract Research Project
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Concluded
|
| 2011/01/01 - 2012/12/31 | Development of bioprocesses for human Mesenchymal Stem Cells for Cell Therapy applications; Part 1 – Optimization of hMSC
expansion in bioreactors
Contract Research Project
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Concluded
|
| 2011/01/01 - 2012/12/31 | Strategic Project - LA 4 - 2011-2012
PEst-OE/EQB/LA0004/2011
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Fundação Calouste Gulbenkian, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal Universidade NOVA de Lisboa NOVA Medical School, Portugal |
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2010/01/01 - 2011/12/31 | Neuronal cell models for pharmacological development
Contract Research Project
Researcher
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Concluded
|
| 2010/01/01 - 2010/12/31 | Development of bioprocesses for Stem Cells for Cell Therapy applications
Contract Research Project
PhD Student Fellow
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Concluded
|
| 2006/01/01 - 2010/12/31 | VITROCELLOMICS, Reducing Animal Experimentation in Preclinical Predictive Drug Testing by Human Hepatic In Vitro Models Derived
from Embryonic Stem Cell
PL018940
PhD Student Fellow
Instituto de Biologia Experimental e Tecnológica, Portugal
|
European Commission Sixth Framework Programme
Concluded
|
Other
| Designation | Funders | |
|---|---|---|
| 2022/02/01 - 2022/06/30 | Role of CCBE1 during coronary vasculature development and neo-angiogenesis upon myocardial infarction, through stimulation
of VEGF-C signaling.
PTDC/MEC-CAR/29590/2017
Instituto de Biologia Experimental e Tecnológica, Portugal
Universidade Nova de Lisboa, Portugal |
Fundação para a Ciência e a Tecnologia
Concluded
|
Outputs
Publications
| Book chapter |
|
| Conference paper |
|
| Conference poster |
|
| Journal article |
|
Activities
Oral presentation
| Presentation title | Event name Host (Event location) |
|
|---|---|---|
| 2020/10/12 | Advancing the manufacture of hPSC-based products for cardiac cell therapy | Cell Therapy Manufacturing & Gene Therapy Global 2020
(virtual meeting)
|
| 2020/09/08 | Bio-inspired Manufacturing of hPSC-based Therapy Products | Advanced Therapies Congress 2020
Terrapin (virtual meeting)
|
| 2019/11/21 | Bioinspired Manufacturing of hPSC-derived Cardiomyocytes for Application in Cardiovascular Regenerative Medicine | 3rd Stem Cell Community Day
(Lisbon, Portugal)
|
| 2019/10/10 | Advancing manufacture of cell therapy products through process understanding | 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
(Lisbon, Portugal)
|
| 2019/09/25 | Advancing Manufacture of Human Pluripotent Stem Cell-based products: New technologies for novel therapies | THE DISCOVERIES CENTRE FOR REGENERATIVE AND PRECISION MEDICINE
(Porto, Portugal)
|
| 2019/08/09 | Cell therapies | 8th International School on Production of Biologicals
UFRJ (Rio de Janeiro)
|
| 2019/06/18 | Bioinspired Manufacturing of Cell Therapy Products for application in Cardiovascular Regenerative Medicine | Workshop "Emerging Technologies and Future Directions in Cardiovascular Regenerative Medicine"
(London)
|
| 2019/05/26 | Advances in Pluripotent Stem Cells cell processing: New technologies for novel therapies | 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
(Coimbra, Portugal)
|
| 2019/03/22 | Engineering scalable manufacturing of high-quality human MSC for cell therapy: from up to downstream processing integration to cell proteome characterization | Bioprocessing Summit Europe 2019
(Lisbon, Portugal)
|
| 2019/03/15 | Advancing Manufacture of functional hPSC-CM through Process understanding | Stem Cell Bioprocessing Seminar- Discoveries Centre for Regenerative and Precision Medicine
(London, United Kingdom)
|
| 2018/10/25 | Advancing Manufacture of hPSC-CM through Product and Process understanding | 5th Annual Stem Cell & Regenerative Medicine Congress
(London, United Kingdom)
|
| 2018/10/11 | Investigação com células estaminais para regeneração cardíaca /O papel da engenharia biomédica | HEART WITHOUT BORDERS...WITH INTERVENTIONAL CARDIOLOGY
(Troia, Portugal)
|
| 2018/10/01 | Bioprocess engineering of human pluripotent stem cells for cell therapy applications and pre-clinical research | MIT-Portugal Annual Conference
(Lisbon, Portugal)
|
| 2018/03/22 | Impact of Bioreactor design on Human Stem Cell Bioprocessing | Bioprocessing Summit Europe
(Lisbon, Portugal)
|
| 2017/04/04 | Bioengineering approaches for up- and downstream processing of human stem cells | 1st Stem Cell Community Day
(Hamburg, Germany)
|
| 2016/12/05 | Stem Cells and Advanced Therapies | WORKSHOP ON NUCLEAR MOLECULAR IMAGING
(Lisbon, Portugal)
|
| 2015/09 | Robust expansion of human pluripotent stem cells: integration of bioprocess design with transcriptomic and metabolomic characterization | 3rd International Meeting of the German Stem Cell Network
(Frankfurt, Germany)
|
| 2014/11/08 | New strategies in stem cell culture | VI LATIN AMERICAN SYMPOSIUM ON CELL CULTURE TECHNOLOGY (VI SLATCC)
FACULTY OF ENGINEERING, PUCV (Chile)
|
| 2014/03/19 | I&D: Made in Portugal | Jornadas de Engenharia Biológica IX, IST-UTL
IST (Lisboa, Portugal)
|
| 2014 | INTEGRATING BIOPROCESS OPTIMIZATION AND -OMICS TOOLS TOWARDS THE DESIGN OF NOVEL STEM CELL THERAPIES FOR CARDIAC REPAIR | ISBioTech – International Society for Bioprocess Technology, 4th Spring Meeting
(Washington, United States)
|
| 2013/11/13 | Bioengineering challenges for up- and down- stream processing of human stem cells for clinical application | European Cell Technology Symposium
(Cardiff)
|
| 2013/02/12 | Bioengineering approaches for culture of human stem cells | Cell Culture World Congress
(Munich, Germany)
|
| 2012/10/22 | Stem Cells and Nanotechnology" | III Simpósio Científico de Saúde AEFFUL - Improving Health: Nanotechnology
(Lisbon, Portugal)
|
Supervision
| Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
|---|---|---|
| 2019/04/01 - Current | Pulsed Electric Fields for valorization of platelets with no therapeutic value into a high biomedical potential product
Supervisor of Daniela Salvador, PhD
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2017/10/01 - Current | Functionalizing biomaterials for application in Cardiovascular Regenerative Medicine
Co-supervisor of Henrique Almeida
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2017/10/01 - Current | Metabolic signatures of human pluripotent stem cells derived cardiomyocytes for improved cell therapy
Co-supervisor of Marta Paiva
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2023/09/01 - 2027/08/31 | Bioprocess Engineering of Extracellular Vesicles derived from hiPSC for Cardiac Repair
Supervisor
|
Molecular Biosciences (PhD)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2023/09/01 - 2027/08/31 | Advancing the manufacture of CAR-T cells for Acute Lymphoblastic Leukemia
Supervisor of Beatriz Painho
|
Molecular Biosciences (PhD)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2023/01/01 - 2026/12/31 | Bioprocess engineering of CAR-T cells and extracellular vesicles with improved clinical relevance
Supervisor
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2021/04/01 - 2024/03/31 | Bioengineering strategies for the manufacturing of hiPSC-cardiac derivatives for the development of BioVADs
Supervisor
|
PhD Program - Engineering Cell therapies and Regenerative Medicine (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
|
| 2020/01/01 - 2021/12/31 | Bioprocess Engineering of a human 3D Cell Model for Primary Hyperoxaluria Type 1
Supervisor of Pedro Vicente
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2021/02/22 - 2021/11/30 | Bioprocess engineering of genetic modified MSC and derived EV for the development of cardiac Patches for heart regeneration
Supervisor
|
Mestrado Integrado em Engenharia Biomédica (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
|
| 2020/10/01 - 2021/11/30 | Isolation of EVs from platelet concentrates
Co-supervisor
|
Mestrado Biotecnologia (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
|
| 2020/10/01 - 2021/11/30 | Improving functional maturation of hPSC-derived hepatocytes
Supervisor
|
Mestrado em Biotecnologia (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
|
| 2018/01/01 - 2021 | Generation and large-scale expansion of highly functional hPSC-derived hepatocytes for cellular therapies and bioengineered
livers: the unknown role of human intestinal microbiome
Co-supervisor of Joana Almeida
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2020/01/03 - 2020/12/31 | Investigating the therapeutic potential of extracellular vesicles from hiPSCs and hiPSC-derived cardiac cells for heart regeneration
Supervisor
|
Mestrado Integrado Eng Biomedica (Master) |
| 2019/01/01 - 2020/12/31 | Extracellular matrix derived constructs as 3D cardiac models for disease modelling and cell-based therapies
Supervisor of Ana Filipa Louro
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2017/01/01 - 2020/12/31 | Role of Ccbe1 during coronary vasculature development and neo-angiogenesis through stimulation of VEGFC signaling
Co-supervisor of Ricardo Lobo
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2018 - 2019 | Development of a 3D strategy for differentiation of HIPSC into cardiomyocytes
Supervisor of Catarina Gomes
|
Mestrado em Engenharia Biomédica, Instituto Superior Técnico, Universidade de Lisboa. (Master)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2018 - 2019 | Differentiation of HIPSCs into cardiac fibroblasts
Supervisor of Cláudia Diniz
|
Mestrado em Engenharia Biomédica, Instituto Superior Técnico, Universidade de Lisboa (Master)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2018 - 2019 | Engineered hiPSC cardiac tissues
Supervisor of Miguel Tenreiro
|
Mestrado em Engenharia Biomédica, Instituto Superior Técnico (Master)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2017 - 2018 | Disclosing CCBE1 role in Cardiac Differentiation of Human Pluripotent Stem Cells
Supervisor of Pedro Vicente
|
Mestrado em Biotecnologia, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa (Master)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2017 - 2018 | 3D hiPSC to hepatocyte differentiation in bioreactor for Primary Hyperoxaluria type I disease model
Supervisor of Mara Domingues
|
Mestrado em Biotecnologia, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa. (Master)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2017 - 2018 | Towards a bioinspired 3D triculture hiPSC-derived cardiac tissue model for human heart microenvironment recapitulation and
drug testing
Supervisor of Pedro Costa
|
Mestrado em Biotecnologia, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa (Master)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2017 - 2018 | Unveiling human Cardiac Stem Cells role in myocardial ischemia-reperfusion injury
Supervisor of Ivo Reis
|
”, Mestrado em Biotecnologia, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa (Master)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2014 - 2018 | Development of a Human Induced Pluripotent Stem Cell Derived Cardiac Model: From Bioprocess Intensification to Heterotypic
Cell Cultures
Co-supervisor of Bernardo Abecasis
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2014 - 2018 | The key role of CCBE1 growth factor in cardiac lineage commitment, from human pluripotent stem cells towards cardiomyocytes
Co-supervisor of Marta Silva
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2014 - 2018 | Towards novel stem cell and protein-based therapies for myocardium regeneration
Co-supervisor of Maria João Sebastião
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2013 - 2017 | Development of integrated strategies for the downstream processing of human stem cells for clinical application
Supervisor of Bárbara Cunha
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2012 - 2017 | Bioprocessing of human Pluripotent Stem Cells for cardiac cell therapy and pre-clinical research
Co-supervisor of Claudia Correia
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2014/11/01 - 2016/09/30 | Expansion of hiPSC as 3D aggregates in ST bioreactors
Supervisor of Emilie Arnault
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2015 - 2016 | Exploring the role of metabolism in the differentiation and maturation of human pluripotent stem cell derived cardiomyocytes
Supervisor of Patricia Duarte
|
Mestrado em Biologia Molecular e Genética, Faculdade de Ciências da Universidade de Lisboa (Master)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2014/09/01 - 2015/08/31 | Bioprocessing of hMSC for cell therapy
Supervisor of Madalena Carido
|
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2014 - 2015 | Application of metabolic systems biology to the production of cell- and virus-based therapeutics
Supervisor
|
Mestrado em Bioquímica, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa (Master)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2014 - 2015 | Development and characterization of scalable bioprocesses for the production of human mesenchymal stem cells
Supervisor of Christina Müller
|
Master of Science Degree in Umweltplanung und Ingenieurökologie At Technische Universität München (TUM), Germany (Master)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2013 - 2014 | Integrated strategies for up- and down-stream bioprocessing of human mesenchymal stem cells
Supervisor of Tiago Aguiar
|
Mestrado em Engenharia Biológica, Instituto Superior Técnico, Universidade de Lisboa (Master)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2012 - 2013 | Avaliação da Capacidade Antioxidante de Extractos Naturais de Maçã e Azeitona usando Modelos Celulares em Monocamada (2D)
e Agregados (3D)
Co-supervisor of Mário Bordalo
|
Mestrado em Engenharia Biotecnológica, Universidade Lusófona de Humanidades e Tecnologias (Master)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
| 2012 - 2013 | Integrated bioprocesses for the differentiation and purification of induced pluripotent stem cells into cardiomyocytes for
cardiovascular research
Supervisor of Nuno Espinha
|
Mestrado em Biotecnologia, FCT NOVA (Master)
Instituto de Biologia Experimental e Tecnológica, Portugal
|
Event organisation
| Event name Type of event (Role) |
Institution / Organization | |
|---|---|---|
| 2018/01 - Current | Co-chair of a Scientific Session at ECI-Single Use Technologies (2018) (2018/10)
Conference
|
|
| 2015/01 - Current | Member of the Organizing Committee of the 9th International Meeting of the SPCE-TC (2015/10)
Conference (Member of the Organising Committee)
|
|
| 2014/12 - Current | Member of the Scientific Committee of ESACT2015 Meeting (2015/04)
Congress (Member of the Scientific Committee)
|
|
| 2014/01 - Current | Member of the Organizing Committee of the “iBET Day – 25Years” (2014) (2014/06)
Meeting (Member of the Organising Committee)
|
|
| 2004/03 - Current | Participation in the organization of “3rd Recombinant Protein Production Meeting”, Faro, Portugal (2004) (2014/06)
Conference (Other)
|
|
| 2022/06/01 - 2023/04/27 | Chair of the Workshops of Cell Culture Engineering Conference 2023 (2023/04/22)
Conference (Other)
|
Event participation
| Activity description Type of event |
Event name Institution / Organization |
|
|---|---|---|
| 2021/02/11 - Current | Participation in the “Ciclo de Workshops Raparigas nas Engenharias e Tecnologias | Dia das Raparigas na Ciência: Engenharia é Ciência?” |
Jury of academic degree
| Topic Role |
Candidate name (Type of degree) Institution / Organization |
|
|---|---|---|
| 2021/01/19 | Development for scalable generation of functional liver microtissues/organoids from human pluripotent stem cells
(Thesis) Main arguer
|
Saeed Abbasalizadeh (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
|
| 2020/01 | Three-dimensional Culture Systems for the Study of Human Pluripotent Stem Cells: Microarrays and Spheroids
(Thesis) Main arguer
|
Jorge Filipe da Conceição Pascoal (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
|
| 2018/11 | Scalable Platform for the Expansion of Human Mesenchymal Stem/Stromal Cells
Under Dynamic Conditions
(Thesis) Main arguer
|
Francisco António Guilherme Moreira (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
|
| 2016/07 | Role of CCBE1 during Cardiac Differentiation of Mouse Embryonic Stem Cells
(Thesis) Arguer
|
Tiago Manuel Santos Justo (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
|
| 2014/11 | Depicting the Mechanism of Action of na ATMP for the Development of the Potency Assay
(Thesis) Main arguer
|
Eduarda Isabel Anacleto Espadinha (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
|
Association member
| Society Organization name | Role | |
|---|---|---|
| 2017 - Current | Sociedade Portuguesa de Células Estaminais e Terapia Celular | |
| 2009 - Current | European society of animal Cell Technology | |
| 2012 - 2015 | ISSCR |
Conference scientific committee
| Conference name | Conference host | |
|---|---|---|
| 2019/04 - Current | ESACT2019 |
Course / Discipline taught
| Academic session | Degree Subject (Type) | Institution / Organization | |
|---|---|---|---|
| 2014 - Current | Coordinator of the Curricular Core Unit “Stem Cell Engineering” (6 ECTS) from PhD Program Bioengineering of Cell Therapies and Regenerative Medicine (IST, CEDOC, IMM and iBET; with Margarida Diogo); Supervisor of Seed Projects (3 months each, total 3) (2014-2018). | ||
| 2014 - Current | Coordinator of the Curricular Core Unit “Advanced Therapy Medicinal Products-ATMP” (1.5 ECT) of the ITQB NOVA PhD Program in Molecular Biosciences (with Ana Sofia Coroadinha); Supervisor of Labrotations (2 weeks each, total 2) (2014-2018). | ||
| 2014 - Current | Biochemistry for Health Master (ITQB NOVA and FCT NOVA) – lecture on “Stem Cell Engineering for Cell Therapy” in the “Biopharmaceuticals” course (3 ECTS). | ||
| 2014 - Current | Biochemistry Master (FCT NOVA) – lecture on “Stem Cell Engineering for Cell Therapy” in Animal Cell Biotechnology Course (3 ECTS). | ||
| 2014 - Current | Invited to lectures on Stem Cells Bioengineering and Cell Therapies in Master Programs at Universidade do Algarve (Mestrado em Ciências Biomédicas, 2019) and Faculdade de Ciências da Universidade de Lisboa (Mestrado em Biologia Molecular e Genética, 2014). | ||
| 2011 - Current | Invited to lectures on Stem Cells Bioengineering, ATMP and Cell Therapies Manufacturing in PhD Programs at Universidade de Coimbra (CNC PhD program at Centro de Neurociencias e Biologia Celular, Faculdade de Medicina, 2013), Universidade do Algarve (PhD program ProRegeM of Centre for Biomedical Research, 2017-2018), Universidade Nova de Lisboa (ITQB PhD Program, 2011-2012). | ||
| 2022/09/30 - 2023/10/31 | 3rd Bioprocessing and Manufacturing of Gene and Cell Therapy Products Course | Bioprocessing and Manufacturing of Gene and Cell Therapy Products Course (Outros) | Intituto de Biologia Experimental e Tecnológica, Portugal |
| 2014 - 2018 | Lecturer of the MIT-Portugal PhD Program, Bioengineering Program: lectures on “Bioprocess Engineering of human pluripotent stem cells for clinical application” (1.5h) in the Cell and Tissue Engineering Course (2016) and “Stem Cell Bioengineering – up and downstream processing” (3h) in the Stem Cell Engineering Course (2018); Supervisor of Lab rotations (3 months each) from MIT-Portugal PhD Program, in Bioengineering (total 9) (2014-2018). | ||
| 2007 - 2018 | Chemical and Biochemical Engineering Master – lecture of “Células Estaminais e Terapia Celular Estratégias em Bioengenharia in “Animal Cell Technology module” in Biochemical Engineering II Course (3 ECTS). |
Journal scientific committee
| Journal title (ISSN) | Publisher | |
|---|---|---|
| 2019 - Current | Biotechnology Advances (0734-9750) | Elsevier |
| 2019 - Current | Nature Communications (2041-1723) | Springer Science and Business Media LLC |
| 2018 - Current | Journal of Tissue Engineering and Regenerative Medicine (1932-7005) | Wiley (John Wiley & Sons) |
| 2018 - Current | ACS Biomaterials Science & Engineering (2373-9878) | American Chemical Society |
| 2017 - Current | Stem Cell Reports (2213-6711) | Elsevier |
| 2017 - Current | Scientific Reports (2045-2322) | Springer Science and Business Media LLC |
| 2015 - Current | Tissue Engineering (1076-3279) | Mary Ann Liebert |
| 2013 - Current | STEM CELL and Translational Medicine | |
| 2011 - Current | Journal of Biotechnology (0168-1656) | Elsevier |
| 2011 - Current | Biotechnology and Bioengineering (1097-0290) | Wiley (John Wiley & Sons) |
| 2011 - Current | Journal of Neuroscience Research (1097-4547) | Wiley (John Wiley & Sons) |
Other jury / evaluation
| Activity description | Institution / Organization | |
|---|---|---|
| 2021/07/12 - Current | Juri de Provas de Doutoramento - Diogo Nogueira - Engineering Characterization of Bioreactors for Human Pluripotent Stem Cell Expansion and Cardiac Differentiation | |
| 2019 - Current | Member of Jury for poster evaluation on ESACT Meeting 2019 | |
| 2011 - Current | Reviewer for Nature Communications, Circulation, Stem Cell Reports, Scientific Reports, STEM CELL and Translational Medicine, Tissue Engineering, Journal of Biotechnology, Biotechnology and Bioengineering, Journal of Neuroscience Research, Biotechnology Advances, etc. |
Distinctions
Other distinction
| 2018 | Best Poster Award |
| 2017 | Best Poster Snapshot Award at the Conference Scale-up and Manufacturing of Cell-based Therapies V, San Diego, USA.
Extendicare Canada Inc, Canada
|
| 2014 | 1st Prize - Best Poster Award at the conference Scale-up and Manufacturing of Cell-based Therapies |
| 2013 | ACTIP Fellowship Award 2013-2014 |
| 2013 | ECI Registration Fund Award for participation in the Integrated Continuous Biomanufacturing Inaugural Conference |
| 2013 | ESACT Bursary Award for participation in the 23rd Meeting of the European Society of Animal Cell Technology |
| 2013 | ECI Registration Fund Award for participation in the Scale-up and Manufacturing of Cell-based Therapies II Conference |
| 2009 | ESACT Bursary Award for participation in the 22nd Meeting of the European Society of Animal Cell Technology |
| 2008 | Travel Fund Award for participation in the Cell Culture Engineering Conference |