Personal identification

Full name

João Ruben Lucas Mota Perdigão

Citation names

• Perdigão, João

Author identifiers

Ciência ID

991C-F26A-9843

ORCID iD

0000-0002-0339-1305

Scopus Author Id

24723211800

Email addresses

• jperdigao@ff.ulisboa.pt (Professional)

Telephones

Telephone

• (+351) 217946440 (Professional)
• (+351) 217946400 Ext.: 14263/2 (Professional)

Addresses

• Instituto para Investigação do Medicamento - iMed.ULisboa, Faculdade de Farmácia da Universidade de Lisboa. Av. das Forças Armadas, 1649-019, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

• Medical and Health Sciences - Health Sciences - Infectious Diseases

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)

	Degree	Classification
2013 Concluded	Doutoramento em Farmácia, especialidade de Microbiologia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal "Molecular and genomic Epidemiology of Multidrug Resistant Mycobacterium tuberculosis Isolates in Lisbon, Portugal" (THESIS/DISSERTATION)	Distinção e Louvor (Unanimidade))
2011 Concluded	Pathogen Genomic Epidemiology (Short-course 2 days) (Outros) London School of Hygiene & Tropical Medicine, United Kingdom "n/a" (THESIS/DISSERTATION)	n/a
2008 Concluded	Mestrado em Biologia Molecular e Genética / Masters Degree in Molecular Biology and Genetics (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal "Tuberculose Multirresistente em Lisboa" (THESIS/DISSERTATION)	18 (Excellent)
2006 Concluded	Curso Pós-Graduado de Especialização em Biologia / Post-Graduate Course on Biology Specialization (Pós-Graduação) Universidade de Lisboa Faculdade de Ciências, Portugal "Caracterização de estirpes de <i>Mycobacterium tuberculosis</i> por análise mutacional dos genes associados à resistência / Characterization of <i>Mycobacterium tuberculosis</i> strains by mutational analysis of resistance-associated genes" (THESIS/DISSERTATION)	19
2005 Concluded	Biologia Microbiana e Genética / Microbial Biology and Genetics (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal "-" (THESIS/DISSERTATION)	15

Science

	Category Host institution	Employer
2019/06/17 - Current	Contracted Researcher (Research)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Others

	Category Host institution	Employer
2021/01/01 - Current	Editorial Board Member of Diagnostics Journal (MDPI group), Switzerland.	MDPI AG, Switzerland
2017/01/01 - Current	Curator Tuberculosis International Database CPLP-TB	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - 2023	Co-Editor of Special Issue “Detection and Surveillance of Mycobacterium tuberculosis” in Diagnostics	MDPI AG, Switzerland
2014/12/01 - 2019/06/16	Post-Doctoral Fellow FCT	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2014/02/01 - 2014/11/30	Post-Doctoral Researcher	Universidade de Lisboa Faculdade de Farmácia, Portugal
2009/03/01 - 2013/07/01	Research Assistant / PhD Student	Universidade de Lisboa Faculdade de Farmácia, Portugal
2005/09/01 - 2009/02/28	Researcher	Universidade de Lisboa Faculdade de Farmácia, Portugal

Contract

	Designation	Funders
2020/01/01 - Current	Advancing drug discovery by synthetic modifications of natural shikimic acid NA Researcher Balgarska academija na naukite, Bulgaria	Fond Nauchni Izsledvaniya Ongoing
2018/06/01 - 2021/05/31	Target@TB. Explorando uma nova ferramenta química para desvendar novas terapias e alvos moleculares na tuberculose PTDC/MED-FAR/30266/2017	Fundação para a Ciência e a Tecnologia Ongoing
2015/05/01 - 2017/04/30	Morbility and Nature of Non-Tuberculous Mycobacteria (NTM) Infections in a cohort of Human Immunodeficiency Virus (HIV) infected patients PGG/064/2014 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Gilead Sciences Lda Concluded
2015/03/01 - 2017/02/28	Transcriptomic profiling of clinical Mycobacterium tuberculosis strains: global transcriptomic response towards drug exposure and metabolic shift towards latency NA Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	European Society of Clinical Microbiology and Infectious Diseases Concluded
2012/03/21 - 2015/09/30	Epidemiologia molecular, resistência aos antibacilares e patogénese do VIH e da tuberculose em Angola: o Coorte Perinatal de VIH de Angola (APEHC) PTDC/SAU-EPI/122400/2010 Egas Moniz Cooperativa de Ensino Superior CRL, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01/01 - 2012/01/01	Diagnostics and Molecular Epidemiology of M/XDR-TB in Greater Lisbon: early detection in preventing the emergence and dissemination of extensively drug resistant M. tuberculosis strains FCG SDH49, P-99934 Researcher Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Fundação Calouste Gulbenkian Concluded
2008/01/01 - 2011/06/30	Dinâmica fisiológica e mutacional da resistência aos antibióticos em Mycobacterium tuberculosis: a emergência da Tuberculose Multi-Resistente. PTDC/BIA-MIC/71280/2006 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade Nova de Lisboa Unidade de Ensino e Investigação de Parasitologia Médica, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2018/09/01 - 2019/12/31	NanoBaR – Development of an advanced topical insulin formulation for skin burn regeneration: an experimental approach from fundamental research to translational research NA Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Universidade de Lisboa Instituto de Investigação do Medicamento Concluded

Publications

Conference poster	Modesto AM; Charleston J; Florez de Sessions P; Hibberd, M.L.; Clark, T.G.; Perdigão, João; Duarte, Aida. "blaCTX-M-15 dissemination across multiple plasmidic scaffolds among multidrug resistant Klebsiella pneumoniae clinical isolates". Paper presented in 29th ECCMID, 2019. Perdigão, João; Silva, C.; Diniz, Jaciara de Lourdes do Carmo Guimarães; Pereira, C.; Machado, Diana; Ramos, J.; Silva Fe; et al. "Mycobacterium tuberculosis genetic diversity and drug resistance across Portuguese-speaking countries and CPLP-TB: a novel framework and surveillance tool for the Lusophone community". Paper presented in 29th ECCMID, 2019. Perdigão, João; Modesto, AM.; Pereira, A.; Neto, O.; Matos, V.; Godinho, A.; Charleston J; et al. "Whole genome sequencing based analysis of a multiclonal beta-lactam and carbapenem resistant Klebsiella pneumoniae in a tertiary care hospital in Lisbon, Portugal". Paper presented in 29th ECCMID, 2019. Modesto, AM.; Charleston, J.; Florez de Sessions P; Hibberd, M.; Clark, T.G.; Duarte, Aida; Perdigão, João. "Emergence of arr2 ribosyl transferase in Klebsiella pneumoniae clinical isolates in Portugal and additional rifampicin resistance mechanisms in Acinetobacter baumannii, Escherichia coli and Pseudomonas aeruginosa mutants". Paper presented in 29th ECCMID, 2019. Joadas, A.; Nicolau, B.; Perdigão, João; Duarte, Aida. "Third generation cephalosporins resistance in pathogenetic and commensal Escherichia coli from urban wastewaters". Paper presented in 29th ECCMID, 2019. Modesto AM; de Sessions, PF.; Hibberd, M.; Clark, T.G.; Duarte, Aida; Perdigão, João. "Plasmid diversity and mobilization across multidrug resistant Klebsiella pneumoniae clinical isolates from different sequence types". Paper presented in 10th iMed.ULisboa Postgraduate Students Meeting & 3rd i3DU Meeting, 2018. Modesto, AM.; de Sessions, PF.; Portugal, I.; Hibberd, M.; Clark, T.G.; Duarte, Aida; Perdigão, João. "Molecular basis for rifampicin resistance in Acinetobacter baumanni, Escherischia coli and Pseudomonas aeruginosa in invitro isolated mutants and emergence of arr2 among Klebsiella pneumoniae clinical isolates". Paper presented in 3rd International Congress of CiiEM, 2018. Perdigão, João; Ginó, D.; Modesto, AM.; de Sessions PF; Portugal, I.; Hibeerd M; Clark, T.G.; Duarte, Aida. "Avibactam inhibitor of beta-lactamases: ESBLs, carbapenemases, cephalosporinases and oxacilinases". Paper presented in 3rd International Congress of CiiEM, 2018. Perdigão, João; Silva, C.; Diniz, Jaciara de Lourdes do Carmo Guimarães; Pereira C.; Machado, Diana; Ramos J.; Silva F.; et al. "CPLP-TB: a novel framework and surveillance tool for tracing Mycobacterium tuberculosis strains across Lusophone countries". Paper presented in 1st Symposia on Tuberculosis and Non-Tuberculous Mycobacteria Research in Portugal, 2018. Pereira C.; Macedo, R.; Silva, C.; Perdigão, João; Portugal, I.. "Molecular epidemiological perspective on the Mycobacterium tuberculosis population structure among immigrants in Lisbon, Portugal". Paper presented in 27th ECCMID, 2017. Diniz, Jaciara de Lourdes do Carmo Guimarães; Ramis I.; Abilleira, F.; Brum, C.; von Groll, A.; Silva A.; Ramos D.; et al. "Insights from the molecular epidemiological analysis of tuberculosis relapse cases in Rio Grande do Sul, Brazil". Paper presented in 27th ECCMID, 2017. Diniz, Jaciara de Lourdes do Carmo Guimarães; Perdigão, João; Ramos D.; Campino, S.; Viveiros, Miguel; McNerney, R.; Pain, A.; et al. "Whole-genome sequencing enables differentiation of tuberculosis reinfection with strains bearing the same genotypic patterns". Paper presented in 27th ECCMID, 2017. Perdigão, João; Clemente, S.; Ramos, J.; Masakidi, P.; Machado, Diana; Silva, C.; Couto, I.; et al. "First Insights on the Drug resistance and Genetic Diversity of Mycobacterium tuberculosis in Luanda, Angola". Paper presented in 26th ECCMID, 2016. Perdigão, João; Maltez, F.; Machado, Diana; Silva H.; Silva, C.; Couto, I.; Viveiros, Miguel; Portugal, I.. "Extensively Drug Resistant Tuberculosis plus Linezolid Resistance: the first report of Linezolid resistance development in Lisbon, Portugal". Paper presented in 26th ECCMID, 2016. Silva, C.; Perdigão, João; Jordão, L.; Portugal, I.. "Identification of the best MIRU-VNTR set technique for MDR-TB and XDR-TB surveillance in Lisbon, Portugal". Paper presented in Congress of the European Society of Mycobacteriology, 2015. Silva, C.; Perdigão, João; Jordão, L.; Portugal, I.. "Studying the metabolic activity of Mycobacterium tuberculosis through a new resazurin reduction based assay". Paper presented in Congress of the European Society of Mycobacteriology, 2015. Perdigão, João; Clemente, S.; Ramos, J.; Masakidi, P.; Machado, Diana; Silva, C.; Couto, I.; et al. "Drug Resistance and Genetic Diversity of Mycobacterium tuberculosis in Luanda, Angola: a Molecular Epidemiological Perspective". Paper presented in Congress of the European Society of Mycobacteriology, 2015. Dalla Costa, E.R.; Vasconcelos S.; Esteves, L.; Gomes H.; Gomes L.; Silva PA; Perdigão, João; et al. "Misclassification by Spoligotyping: Multidrug Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage Wrongly Identified as Mycobacterium pinnipedii (ST863)". Paper presented in Congress of the European Society of Mycobacteriology, 2015. Perdigão, João; Macedo, R.; Machado, Diana; Silva, C.; Jordão, L.; Couto, I.; Viveiros, Miguel; Portugal, I.. "Polymorphism in gidB gene as a genetic marker for the Mycobacterium tuberculosis Q1 cluster and implications for the streptomycin resistance level". Paper presented in MicroBiotec’13, 2013. Machado, Diana; Perdigão, João; Ramos, J.; Couto, I.; Portugal, I.; Viveiros, Miguel. "Correlation between phenotypic and genetic resistance to first and second line antituberculosis drugs in a high tuberculosis endemic área". Paper presented in MicroBiotec’13, 2013. Silva, C.; Perdigão, João; Jordão, L.; Portugal, I.. "Novel mutations in pncA, associated with catalytic centre, might be related with PZA high resistance profile". Paper presented in MicroBiotec’13, 2013. Machado, Diana; Pires, D.; Perdigão, João; Ramos, J.; Couto, I.; Portugal, I.; Anes, E.; Viveiros, Miguel. "Efflux inhibitors against drug resistant Mycobacterium tuberculosis: Antimicrobial agentes and enhancers of macrophage killing activity". Paper presented in MicroBiotec’13, 2013. Perdigão, João; Macedo R.; Silva, C.; Portugal, I.. "Laboratory data on drug-resistant tuberculosis in Lisbon Health Region". Paper presented in Tuberculosis 2012: Biology, pathogenesis, intervention strategies, 2012. Perdigão, João; Silva, D.; Pereira, V.; Macedo, R.; Silva, C.; Machado, Diana; Couto, I.; et al. "Dynamics and development of extensively drug-resistant tuberculosis, Portugal". Paper presented in Tuberculosis 2012: Biology, pathogenesis, intervention strategies, 2012. Silva, C.; Perdigão, João; Jordão, L.; Portugal, I.. "Molecular analysis on resistant TB isolates in Portugal". Paper presented in Tuberculosis 2012: Biology, pathogenesis, intervention strategies, 2012. Perdigão, João; Silva, D.; Macedo, R.; Brum, L.; Portugal, I.. "Occurrence of eis gene mutations among extensively drug-resistant tuberculosis strains". Paper presented in 22nd ECCMID, 2012. Perdigão, João; João, I.; Portugal, I.; Silva, C.; Jordão, L.. "Characterization of Mycobacterium tuberculosis resistant strains circulating in a Lisbon hospital: a 2-year study". Paper presented in Eighth International Conference on the Pathogenesis of Mycobacterial Infections., 2011. Perdigão, João; Silva, D.; Macedo, R.; Brum, L.; Portugal, I.. "Mutational analysis of eis gene in injectable second-line Mycobacterium tuberculosis drug-resistant strains". Paper presented in 32nd Annual Congress of the European Society of Mycobacteriology, 2011. Silva, C.; Perdigão, João; Couto, I.; Viveiros, Miguel; Jordão, L.; Portugal, I.. "Deletion analysis on multidrug-resistant Mycobacterium tuberculosis in Portugal". Paper presented in 32nd Annual Congress of the European Society of Mycobacteriology, 2011. Macedo, R.; Perdigão, João; Pereira, E.; Portugal, I.. "Multidrug and Extensively Drug Resistant Tuberculosis in Lisbon Health Region in 2008-2010". Paper presented in 32nd Annual Congress of the European Society of Mycobacteriology, 2011. Perdigão, João; Macedo, R.; Silva, C.; Pinto, C.; Furtado, C.; Portugal, I.. "Perspectiva Laboratorial da Tuberculose Resistente na Região de Saúde de Lisboa". Paper presented in X & VIII Congresso Nacional de Doenças Infecciosas e Microbiologia Clínica & sobre SIDA, 2010. Perdigão, João; Silva, C.; Portugal, I.. "Phylogenetic characterization of Mycobacterium tuberculosis Lisboa strains by Single Nucleotide Polymorphism analysis". Paper presented in 31st Annual Congress of the European Society of Mycobacteriology, 2010. Perdigão, João; Pinto, C.; Moniz-Pereira, J.; Portugal, I.. "Mycobacterium tuberculosis strain adaptation: Family Lisboa and mapping of IS6110". Paper presented in 31st Annual Congress of the European Society of Mycobacteriology, 2010. Perdigão, João; Macedo, R.; Brum, L.; Portugal, I.. "Cluster differentiation by gyrA mutation analysis in extensive drug-resistant tuberculosis". Paper presented in 31st Annual Congress of the European Society of Mycobacteriology, 2010. Perdigão, João; Macedo, R.; Silva, C.; Pinto, C.; Furtado, C.; Brum, L.; Portugal, I.. "Laboratory data report on drug-resistant tuberculosis in Lisbon Health Region between 2001-2006". Paper presented in 31st Annual Congress of the European Society of Mycobacteriology, 2010. Perdigão, João; Pinto, C.; Moniz-Pereira, J.; Portugal, I.. "Clues to enhanced virulence in Mycobacterium tuberculosis: Mapping of IS6110 in Lisboa strains". Paper presented in 20th ECCMID, 2010. Perdigão, João; Macedo, R.; Brum, L.; Portugal, I.. "Cluster association of gyrA mutations in extensively drug-resistant tuberculosis isolates from Lisbon, Portugal". Paper presented in 20th ECCMID, 2010. Perdigão, João; Silva, C.; Portugal, I.. "Deletion and Single Nucleotide Polymorphism typing of Mycobacterium tuberculosis Lisboa family strains in Portugal". Paper presented in 20th ECCMID, 2010. Veigas, B.; Perdigão, João; Portugal, I.; Couto, I.; Viveiros, Miguel; Baptista, P.. "Use of Au-nanoprobes for the detection of SNPs associated with antibiotic resistance in Mycobacterium tuberculosis". Paper presented in MicroBiotec09, 2009. Perdigão, João; Silva, C.; Portugal, I.. "Genomic characterization of Lisboa family strains by deletion analysis". Paper presented in 30th Annual Congress of the European Society of Mycobacteriology, 2009. Perdigão, João; Sabino, A.; Milho, C.; Macedo, R.; Brum, L.; Portugal, I.. "Characterization of gidB gene in Mycobacterium tuberculosis in Lisbon Health Region: role in streptomycin resistance and epidemiological Marker". Paper presented in 30th Annual Congress of the European Society of Mycobacteriology, 2009. Perdigão, João; Ferreira, A.; Malaquias, A.; Macedo, R.; Brum, L.; Portugal, I.. "Mutational analysis of genes associated with resistance to second-line injectable drugs in Mycobacterium tuberculosis clinical isolates from Lisbon, Portugal". Paper presented in 30th Annual Congress of the European Society of Mycobacteriology, 2009. Perdigão, João; Milho, C.; Furtado, C.; Carrilho, L.; Brum, L.; Portugal, I.. "Transmissão da tuberculose em Lisboa: Análise de uma população de estudo e caracterização por Mycobacterial Interspersed Repetitive Unit". Paper presented in XXIV42 Congreso Nacional de la Sociedad Española de Neumología e Cirurgía Torácica, 2009. Perdigão, João; Sabino, A.; Milho, C.; Macedo, R.; Brum, L.; Portugal, I.. "Characterization of gidB gene in streptomycin-resistant Mycobacterium tuberculosis isolates in Lisbon Health Region". Paper presented in 19th ECCMID, 2009. Perdigão, João; Ferreira, A.; Macedo, R.; Brum, L.; Portugal, I.. "Mutations associated with resistance to second-line drugs in Mycobacterium tuberculosis clinical isolates from Lisbon, Portugal". Paper presented in 19th ECCMID, 2009. Perdigão, João; Malaquias, C.; Macedo, R.; Brum, L.; Portugal, I.. "Identificação de mutações no gene tlyA em isolados de Mycobacterium tuberculosis resistentes à capreomicina". Paper presented in XXIV Congresso de Pneumologia, 2008. Perdigão, João; Brum, L.; Portugal, I.. "Transformation of Mycobacterium smegmatis with embB306 codon alleles confers ethambutol low-level resistance". Paper presented in 29th Annual Congress of the European Society of Mycobacteriology, 2008. Perdigão, João; Milho, C.; Furtado, C.; Carrilho, ML.; Brum, L.; Portugal, I.. "Genotyping analysis of tuberculosis clinical isolates from a hospital in Lisbon by Mycobacterial Interspersed Repetitive Unit". Paper presented in 29th Annual Congress of the European Society of Mycobacteriology, 2008. Perdigão, João; Sabino, A.; Milho, C.; Macedo, R.; Brum, L.; Portugal, I.. "Characterization of gidB mutations in streptomycin-resistant isolates in Lisbon, Portugal". Paper presented in 29th Annual Congress of the European Society of Mycobacteriology, 2008. Perdigão, João; Macedo, R.; João, I.; Fernandes, E.; Ribeiro, A.; Brum, L.; Portugal, I.. "Multidrug and extensive drug resistant tuberculosis in Lisbon, Portugal: molecular epidemiology and resistance mechanisms". Paper presented in 18th ECCMID, 2008. Perdigão, João; Ribeiro, A.; Macedo, R.; Brum, L.; Portugal, I.. "Prevalence of embB306 mutations among ethambutol-resistant and susceptible isolates: correlation with ethambutol and multidrug resistance". Paper presented in 18th ECCMID, 2008. Perdigão, João; Macedo, R.; Brum, L.; Portugal, I.. "Occurrence of embB306 mutations in ethambutol-resistant and –susceptible Mycobacterium tuberculosis clinical isolates". Paper presented in MicroBiotec XXXIII JPG, 2007. Perdigão, João; Macedo, R.; Fernandes, E.; Brum, L.; Portugal, I.. "Mutations associated with streptomycin resistance in Mycobacterium tuberculosis: predominance and rapid detection in Lisbon, Portugal". Paper presented in MicroBiotec XXXIII JPG, 2007. Perdigão, João; Macedo, R.; João, I.; Fernandes, E.; Brum, L.; Portugal, I.. "Multidrug-resistant tuberculosis in Lisbon: molecular epidemiology and resistance". Paper presented in 4th Congress of the European Society for Emerging Infections, 2007. Perdigão, João; Macedo, R.; Brum, L.; Portugal, I.. "Mutational characterization of ethambutol resistance-determinating region in ethambutol-resistant Isolates: prevalence of embB306 mutations and their role in ethambutol resistance". Paper presented in 28th Annual Congress of the European Society of Mycobacteriology, 2007. Perdigão, João; Macedo, R.; Brum, L.; Portugal, I.. "Rapid detection of pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal". Paper presented in 28th Annual Congress of the European Society of Mycobacteriology, 2007. Macedo, R.; Perdigão, João; Portugal, I.; Brum, L.. "MDR-TB in Lisbon Area: Data report from 2004 to 2006". Paper presented in 28th Annual Congress of the European Society of Mycobacteriology, 2007. Macedo, R.; Perdigão, João; Portugal, I.; Brum, L.. "XDR and MDR-TB Markers: a way To overcome resistance detection". Paper presented in 28th Annual Congress of the European Society of Mycobacteriology, 2007. Perdigão, João; Macedo, R.; Portugal, I.. "Rapid Detection of Pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal". Paper presented in Second Workshop – Host-Pathogen Interactions and Cell Signaling, 2006. Portugal, I.; Macedo, R.; Fernandes, E.; Perdigão, João; João, I.; Pereira, E.; Brum, L.. "Multidrug-resistant tuberculosis in Lisbon in 2003". Paper presented in 16th ECCMID, 2006.
Journal article	Castillos de Ibrahim das Neves, Yasmin; Reis, Ana Julia; Xavier Maio, Nathália; Vianna, Júlia; Perdigão, João; Bastos Ramis, Ivy; Almeida da Silva, Pedro Eduardo; Von Groll, Andrea. "Genotyping methods and their contributions to the study of tuberculosis dynamic in Latin America". The Journal of Infection in Developing Countries 17 10 (2023): 1373-1386. http://dx.doi.org/10.3855/jidc.17840. 10.3855/jidc.17840 Campaniço, André; Harjivan, Shrika G.; Freitas, Elisabete; Serafini, Marco; Gaspar, M. Manuela; Capela, Rita; Gomes, Pedro; et al. "Structural Optimization of Antimycobacterial Azaaurones Towards Improved Solubility and Metabolic Stability". ChemMedChem 18 24 (2023): http://dx.doi.org/10.1002/cmdc.202300410. 10.1002/cmdc.202300410 Wunrow, Han Yong; Bender, Rose G; Vongpradith, Avina; Sirota, Sarah Brooke; Swetschinski, Lucien R; Novotney, Amanda; Gray, Authia P; et al. "Global, regional, and national burden of meningitis and its aetiologies, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019". The Lancet Neurology 22 8 (2023): 685-711. http://dx.doi.org/10.1016/s1474-4422(23)00195-3. 10.1016/s1474-4422(23)00195-3 Mokrousov, Igor; Vyazovaya, Anna; Shitikov, Egor; Badleeva, Maria; Belopolskaya, Olesya; Bespiatykh, Dmitry; Gerasimova, Alena; et al. "Insight into pathogenomics and phylogeography of hypervirulent and highly-lethal Mycobacterium tuberculosis strain cluster". BMC Infectious Diseases 23 1 (2023): http://dx.doi.org/10.1186/s12879-023-08413-7. 10.1186/s12879-023-08413-7 Elias, Rita; Spadar, Anton; Hendrickx, Antoni P A; Bonnin, Remy A; Dortet, Laurent; Pinto, Margarida; Phelan, Jody E; et al. "Emergence of KPC-3- and OXA-181-producing ST13 and ST17 Klebsiella pneumoniae in Portugal: genomic insights on national and international dissemination". Journal of Antimicrobial Chemotherapy 78 5 (2023): 1300-1308. http://dx.doi.org/10.1093/jac/dkad093. 10.1093/jac/dkad093 Francisco, Pedro; Neves Amaral, Mariana; Neves, Afonso; Ferreira-Gonçalves, Tânia; Viana, Ana S.; Catarino, José; Faísca, Pedro; et al. "Pluronic® F127 Hydrogel Containing Silver Nanoparticles in Skin Burn Regeneration: An Experimental Approach from Fundamental to Translational Research". Gels 9 3 (2023): 200. http://dx.doi.org/10.3390/gels9030200. 10.3390/gels9030200 Busatto, Caroline; Possuelo, Lia Gonçalves; Bierhals, Dienefer; de Oliveira, Carolina Larrosa; de Souza, Mariana Quaresma; Fanfa, Dandara; Barreto, Érika; et al. "Spread of Mycobacterium tuberculosis in Southern Brazilian persons deprived of liberty: a molecular epidemiology study". European Journal of Clinical Microbiology & Infectious Diseases 42 3 (2023): 297-304. http://dx.doi.org/10.1007/s10096-023-04546-4. 10.1007/s10096-023-04546-4 Spadar, Anton; Perdigão, João; Campino, Susana; Clark, Taane G.. "Large-scale genomic analysis of global Klebsiella pneumoniae plasmids reveals multiple simultaneous clusters of carbapenem-resistant hypervirulent strains". Genome Medicine 15 1 (2023): http://dx.doi.org/10.1186/s13073-023-01153-y. 10.1186/s13073-023-01153-y Mestrovic, Tomislav; Robles Aguilar, Gisela; Swetschinski, Lucien R; Ikuta, Kevin S; Gray, Authia P; Davis Weaver, Nicole; Han, Chieh; et al. "The burden of bacterial antimicrobial resistance in the WHO European region in 2019: a cross-country systematic analysis". The Lancet Public Health 7 11 (2022): e897-e913. http://dx.doi.org/10.1016/s2468-2667(22)00225-0. 10.1016/s2468-2667(22)00225-0 Mokrousov, Igor; Slavchev, Ivaylo; Solovieva, Natalia; Dogonadze, Marine; Vyazovaya, Anna; Valcheva, Violeta; Masharsky, Aleksey; et al. "Molecular Insight into Mycobacterium tuberculosis Resistance to Nitrofuranyl Amides Gained through Metagenomics-like Analysis of Spontaneous Mutants". Pharmaceuticals 15 9 (2022): 1136. http://dx.doi.org/10.3390/ph15091136. 10.3390/ph15091136 Spadar, Anton; Phelan, Jody; Elias, Rita; Modesto, Ana; Caneiras, Cátia; Marques, Cátia; Lito, Luís; et al. "Genomic epidemiological analysis of Klebsiella pneumoniae from Portuguese hospitals reveals insights into circulating antimicrobial resistance". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-17996-1. 10.1038/s41598-022-17996-1 Spadar, Anton; Perdigão, João; Campino, Susana; Clark, Taane G.. "Genomic analysis of hypervirulent Klebsiella pneumoniae reveals potential genetic markers for differentiation from classical strains". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-17995-2. 10.1038/s41598-022-17995-2 Elias, Rita; Spadar, Anton; Phelan, Jody; Melo-Cristino, José; Lito, Luís; Pinto, Margarida; Gonçalves, Luísa; et al. "A phylogenomic approach for the analysis of colistin resistance-associated genes in Klebsiella pneumoniae, its mutational diversity and implications for phenotypic resistance". International Journal of Antimicrobial Agents 59 6 (2022): 106581. http://dx.doi.org/10.1016/j.ijantimicag.2022.106581. 10.1016/j.ijantimicag.2022.106581 Slavchev, Ivaylo M.; Mitrev, Yavor; Shivachev, Boris; Valcheva, Violeta; Dogonadze, Marine; Solovieva, Natalia; Vyazovaya, Anna; et al. "Synthesis, Characterization and Complex Evaluation of Antibacterial Activity and Cytotoxicity of New Arylmethylidene Ketones and Pyrimidines with Camphane Skeletons". ChemistrySelect 7 17 (2022): http://dx.doi.org/10.1002/slct.202201339. 10.1002/slct.202201339 Elias, Rita; Melo-Cristino, José; Lito, Luís; Pinto, Margarida; Gonçalves, Luísa; Campino, Susana; Clark, Taane G.; Duarte, Aida; Perdigão, João. "Klebsiella pneumoniae and Colistin Susceptibility Testing: Performance Evaluation for Broth Microdilution, Agar Dilution and Minimum Inhibitory Concentration Test Strips and Impact of the “Skipped Well” Phenomenon". Diagnostics 11 12 (2021): 2352. http://dx.doi.org/10.3390/diagnostics11122352. 10.3390/diagnostics11122352 de Lourdes do Carmo Guimarães Diniz, Jaciara; von Groll, Andrea; Unis, Gisela; Dalla-Costa, Elis Regina; Rosa Rossetti, Maria Lúcia; Vianna, Júlia Silveira; Ramos, Daniela Fernandes; et al. "Whole-genome sequencing as a tool for studying the microevolution of drug-resistant serial Mycobacterium tuberculosis isolates". Tuberculosis 131 (2021): 102137. http://dx.doi.org/10.1016/j.tube.2021.102137. 10.1016/j.tube.2021.102137 Mokrousov, Igor; Vyazovaya, Anna; Sinkov, Viacheslav; Gerasimova, Alena; Ioannidis, Panayotis; Jiao, Weiwei; Khromova, Polina; et al. "Practical approach to detection and surveillance of emerging highly resistant Mycobacterium tuberculosis Beijing 1071-32-cluster". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-00890-7. 10.1038/s41598-021-00890-7 Genestet, Charlotte; Perdigão, João; Herranz, Marta; Maus, Sandra R.; Berland, Jean-Luc; Chiner-Oms, Álvaro; Comas, Iñaki; et al. "Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France". Travel Medicine and Infectious Disease 44 (2021): 102167. http://dx.doi.org/10.1016/j.tmaid.2021.102167. 10.1016/j.tmaid.2021.102167 Salvato, Richard Steiner; Reis, Ana Júlia; Schiefelbein, Sun Hee; Gómez, Michael Andrés Abril; Salvato, Stéphanie Steiner; da Silva, Larissa Vitória; Costa, Elis Regina Dalla; et al. "Genomic-based surveillance reveals high ongoing transmission of multi-drug-resistant Mycobacterium tuberculosis in Southern Brazil". International Journal of Antimicrobial Agents 58 4 (2021): 106401. http://dx.doi.org/10.1016/j.ijantimicag.2021.106401. 10.1016/j.ijantimicag.2021.106401 Gómez-González, Paula J.; Perdigao, Joao; Gomes, Pedro; Puyen, Zully M.; Santos-Lazaro, David; Napier, Gary; Hibberd, Martin L.; et al. "Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-98862-4. 10.1038/s41598-021-98862-4 Elias, Rita; Duarte, Aida; Perdigão, João. "A Molecular Perspective on Colistin and Klebsiella pneumoniae: Mode of Action, Resistance Genetics, and Phenotypic Susceptibility". Diagnostics 11 7 (2021): 1165. http://dx.doi.org/10.3390/diagnostics11071165. 10.3390/diagnostics11071165 Spadar, Anton; Perdigão, João; Phelan, Jody; Charleston, James; Modesto, Ana; Elias, Rita; de Sessions, Paola Florez; et al. "Methylation analysis of Klebsiella pneumoniae from Portuguese hospitals". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-85724-2. 10.1038/s41598-021-85724-2 Mesquita, Elsa; Ribeiro, Rita; Silva, Carla J. C.; Alves, Rita; Baptista, Rita; Condinho, Sílvia; Rosa, Maria João; et al. "An Update on Wastewater Multi-Resistant Bacteria: Identification of Clinical Pathogens Such as Escherichia coli O25b:H4-B2-ST131-Producing CTX-M-15 ESBL and KPC-3 Carbapenemase-Producing Klebsiella oxytoca". Microorganisms 9 3 (2021): 576. http://dx.doi.org/10.3390/microorganisms9030576. 10.3390/microorganisms9030576 Perdigão, João; Caneiras, Cátia; Elias, Rita; Modesto, Ana; Spadar, Anton; Phelan, Jody; Campino, Susana; et al. "Genomic Epidemiology of Carbapenemase Producing Klebsiella pneumoniae Strains at a Northern Portuguese Hospital Enables the Detection of a Misidentified Klebsiella variicola KPC-3 Producing Strain". Microorganisms 8 12 (2020): 1986. http://dx.doi.org/10.3390/microorganisms8121986. 10.3390/microorganisms8121986 Rizvi, S.M. Shahriar; Tarafder, Shirin; Anwar, Shaheda; Perdigão, João; Johora, Fatima Tuj; Sattar, Humayun; Kamal, S.M. Mostofa. "Circulating strains of Mycobacterium tuberculosis: 24 loci MIRU-VNTR analysis in Bangladesh". Infection, Genetics and Evolution 86 (2020): 104634. http://dx.doi.org/10.1016/j.meegid.2020.104634. 10.1016/j.meegid.2020.104634 Verza, Mirela; Scheffer, Mara Cristina; Salvato, Richard Steiner; Schorner, Marcos André; Barazzetti, Fernando Hartmann; Machado, Hanalydia de Melo; Medeiros, Taiane Freitas; et al. "Genomic epidemiology of Mycobacterium tuberculosis in Santa Catarina, Southern Brazil". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-69755-9. 10.1038/s41598-020-69755-9 Perdigão, João; Modesto, Ana; Pereira, A. L.; Neto, O.; Matos, V.; Godinho, A.; Phelan, Jody; et al. "Whole-genome sequencing resolves a polyclonal outbreak by extended-spectrum beta-lactam and carbapenem-resistant Klebsiella pneumoniae in a Portuguese tertiary-care hospital". Microbial Genomics (2020): http://dx.doi.org/10.1099/mgen.0.000349. 10.1099/mgen.0.000349 Salvato, Richard Steiner; Costa, Elis Regina Dalla; Reis, Ana Júlia; Schiefelbein, Sun Hee; Halon, Maria Laura; Barcellos, Regina Bones; Unis, Gisela; et al. "First insights into circulating XDR and pre-XDR Mycobacterium tuberculosis in Southern Brazil". Infection, Genetics and Evolution 78 (2020): 104127. http://dx.doi.org/10.1016/j.meegid.2019.104127. 10.1016/j.meegid.2019.104127 Perdigão, João; Gomes, Pedro; Miranda, Anabela; Maltez, Fernando; Machado, Diana; Silva, Carla; Phelan, Jody E.; et al. "Using genomics to understand the origin and dispersion of multidrug and extensively drug resistant tuberculosis in Portugal". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-59558-3. 10.1038/s41598-020-59558-3 Conceição, Marília Lima da; Conceição, Emilyn Costa; Furlaneto, Ismari Perini; Silva, Sandro Patroca da; Guimarães, Arthur Emil dos Santos; Gomes, Pedro; Boschiroli, María Laura; et al. "Phylogenomic Perspective on a Unique Mycobacterium bovis Clade Dominating Bovine Tuberculosis Infections among Cattle and Buffalos in Northern Brazil". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-58398-5. 10.1038/s41598-020-58398-5 Perdigão, João; Silva, Carla; Maltez, Fernando; Machado, Diana; Miranda, Anabela; Couto, Isabel; Rabna, Paulo; et al. "Emergence of multidrug-resistant Mycobacterium tuberculosis of the Beijing lineage in Portugal and Guinea-Bissau: a snapshot of moving clones by whole-genome sequencing". Emerging Microbes & Infections 9 1 (2020): 1342-1353. http://dx.doi.org/10.1080/22221751.2020.1774425. 10.1080/22221751.2020.1774425 Tatara, Mariana Bento; Perdigão, João; Viveiros, Miguel; Kritski, Afrânio; Silva, Kesia Esther da; Sacchi, Flávia Patussi Correia; de Lima, Camila Camioli; et al. "Genetic Diversity and Molecular Epidemiology of Mycobacterium tuberculosis in Roraima State, Brazil". The American Journal of Tropical Medicine and Hygiene 101 4 (2019): 774-779. http://dx.doi.org/10.4269/ajtmh.19-0324. 10.4269/ajtmh.19-0324 Campaniço, André; Carrasco, Marta P.; Njoroge, Mathew; Seldon, Ronnett; Chibale, Kelly; Perdigão, João; Portugal, Isabel; et al. "Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB". ChemMedChem 14 16 (2019): 1537-1546. http://dx.doi.org/10.1002/cmdc.201900289. 10.1002/cmdc.201900289 Perdigão, João. "CPLP-TB: uma nova ferramenta de vigilância transnacional da tuberculose no espaço lusófono". Anais do IHMT 17 (2019): https://anaisihmt.com/index.php/ihmt/article/view/278. Open access • Published • https://doi.org/10.25761/anaisihmt.278 Pereira, C.; Gomes, P.; Taveira, R.; Silva, C.; Maltez, F.; Macedo, R.; Costa, C.; et al. "Insights on the Mycobacterium tuberculosis population structure associated with migrants from Portuguese-speaking countries over a three-year period in Greater Lisbon, Portugal: Implications at the public health level". Infection, Genetics and Evolution 71 (2019): 159-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063727173&partnerID=MN8TOARS. 10.1016/j.meegid.2019.03.025 Oppong, Y.E.A.; Phelan, J.; Perdigão, J.; MacHado, D.; Miranda, A.; Portugal, I.; Viveiros, M.; Clark, T.G.; Hibberd, M.L.. "Genome-wide analysis of Mycobacterium tuberculosis polymorphisms reveals lineage-specific associations with drug resistance". BMC Genomics 20 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85063796113&partnerID=MN8TOARS. 10.1186/s12864-019-5615-3 Brynildsrud, O.B.; Pepperell, C.S.; Suffys, P.; Grandjean, L.; Monteserin, J.; Debech, N.; Bohlin, J.; et al. "Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation". Science Advances 4 10 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85055073936&partnerID=MN8TOARS. 10.1126/sciadv.aat5869 Perdigão, J.; Portugal, I.. "Genetics and roadblocks of drug resistant tuberculosis". Infection, Genetics and Evolution (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85054444065&partnerID=MN8TOARS. 10.1016/j.meegid.2018.09.023 Machado, D.; Perdigão, J.; Portugal, I.; Pieroni, M.; Silva, P.A.; Couto, I.; Viveiros, M.. "Efflux activity differentially modulates the levels of isoniazid and rifampicin resistance among multidrug resistant and monoresistant Mycobacterium tuberculosis strains". Antibiotics 7 1 (2018): 1-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043286975&partnerID=MN8TOARS. 10.3390/antibiotics7010018 Coll, F.; Phelan, J.; Hill-Cawthorne, G.A.; Nair, M.B.; Mallard, K.; Ali, S.; Abdallah, A.M.; et al. "Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis". Nature Genetics 50 2 (2018): 307-316. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040763196&partnerID=MN8TOARS. 10.1038/s41588-017-0029-0 Phelan, J.; De Sessions, P.F.; Tientcheu, L.; Perdigao, J.; Machado, D.; Hasan, R.; Hasan, Z.; et al. "Methylation in Mycobacterium tuberculosis is lineage specific with associated mutations present globally". Scientific Reports 8 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85040551238&partnerID=MN8TOARS. 10.1038/s41598-017-18188-y Machado, D.; Antunes, J.; Simões, A.; Perdigão, J.; Couto, I.; McCusker, M.; Martins, M.; et al. "Contribution of efflux to colistin heteroresistance in a multidrug resistant acinetobacter baumannii clinical isolate". Journal of Medical Microbiology 67 6 (2018): 740-749. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048060237&partnerID=MN8TOARS. 10.1099/jmm.0.000741 Perdigão, J.; Silva, C.; Diniz, J.; Pereira, C.; Machado, D.; Ramos, J.; Silva, H.; et al. "Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries". Infection, Genetics and Evolution (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85045092372&partnerID=MN8TOARS. 10.1016/j.meegid.2018.03.011 Perdigão, J.; Clemente, S.; Ramos, J.; Masakidi, P.; Machado, D.; Silva, C.; Couto, I.; et al. "Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola". Scientific Reports 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85013662122&partnerID=MN8TOARS. 10.1038/srep42814 Maltez, F.; Martins, T.; Póvoas, D.; Cabo, J.; Peres, H.; Antunes, F.; Perdigão, J.; Portugal, I.. "Multidrug-resistant tuberculosis by strains of beijing family, in patients from Lisbon, Portugal: Preliminary report,Tuberculose multirresistente por estirpes da família beijing, em doentes de Lisboa, Portugal: Estudo preliminar". Acta Medica Portuguesa 30 3 (2017): 175-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016811868&partnerID=MN8TOARS. 10.20344/amp.7882 Nakatani, Y.; Opel-Reading, H.K.; Merker, M.; Machado, D.; Andres, S.; Kumar, S.S.; Moradigaravand, D.; et al. "Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance". Antimicrobial Agents and Chemotherapy 61 12 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85035036736&partnerID=MN8TOARS. 10.1128/AAC.01575-17 Machado, D.; Coelho, T.S.; Perdigão, J.; Pereira, C.; Couto, I.; Portugal, I.; Maschmann, R.D.A.; et al. "Interplay between mutations and efflux in drug resistant clinical isolates of Mycobacterium tuberculosis". Frontiers in Microbiology 8 APR (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85018315571&partnerID=MN8TOARS. 10.3389/fmicb.2017.00711 Perdigão, J.; Clemente, S.; Ramos, J.; Masakidi, P.; Machado, D.; Silva, C.; Couto, I.; et al. "Genetic diversity, transmission dynamics, and drug resistance of Mycobacterium tuberculosis in Luanda, Angola". International Journal of Mycobacteriology 5 (2016): S38-S39. http://www.scopus.com/inward/record.url?eid=2-s2.0-85057460428&partnerID=MN8TOARS. 10.1016/j.ijmyco.2016.09.050 Machado, D.; Pires, D.; Perdigão, J.; Couto, I.; Portugal, I.; Martins, M.; Amaral, L.; Anes, E.; Viveiros, M.. "Ion channel blockers as antimicrobial agents, efflux inhibitors, and enhancers of macrophage killing activity against drug resistant mycobacterium tuberculosis". PLoS ONE 11 2 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84960338991&partnerID=MN8TOARS. 10.1371/journal.pone.0149326 Phelan, J.E.; Coll, F.; Bergval, I.; Anthony, R.M.; Warren, R.; Sampson, S.L.; Gey van Pittius, N.C.; et al. "Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages". BMC Genomics 17 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84959198490&partnerID=MN8TOARS. 10.1186/s12864-016-2467-y Perdigão, J.; Maltez, F.; Machado, D.; Silva, H.; Pereira, C.; Silva, C.; Couto, I.; Viveiros, M.; Portugal, I.. "Beyond extensively drug-resistant tuberculosis in Lisbon, Portugal: a case of linezolid resistance acquisition presenting as an iliopsoas abscess". International Journal of Antimicrobial Agents 48 5 (2016): 569-570. http://www.scopus.com/inward/record.url?eid=2-s2.0-84993949871&partnerID=MN8TOARS. 10.1016/j.ijantimicag.2016.07.026 Rabna, P.; Ramos, J.; Ponce, G.; Sanca, L.; Mané, M.; Armada, A.; Machado, D.; et al. "Direct detection by the xpert MTB/RIF assay and characterization of multi and poly drug- resistant tuberculosis in Guinea-Bissau, West Africa". PLoS ONE 10 5 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84958198245&partnerID=MN8TOARS. 10.1371/journal.pone.0127536 Coll, F.; McNerney, R.; Preston, M.D.; Guerra-Assunção, J.A.; Warry, A.; Hill-Cawthorne, G.; Mallard, K.; et al. "Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences". Genome Medicine 7 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84939257684&partnerID=MN8TOARS. 10.1186/s13073-015-0164-0 Dalla Costa, E.R.; Vasconcelos, S.E.G.; Esteves, L.S.; Gomes, H.M.; Gomes, L.L.; Da Silva, P.A.; Perdigão, J.; et al. "Multidrug-resistant mycobacterium tuberculosis of the Latin American mediterranean lineage, wrongly identified as mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), causing active tuberculosis in South Brazil". Journal of Clinical Microbiology 53 12 (2015): 3805-3811. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947775741&partnerID=MN8TOARS. 10.1128/JCM.02012-15 Coll, F.; Preston, M.; Guerra-Assunção, J.A.; Hill-Cawthorn, G.; Harris, D.; Perdigão, J.; Viveiros, M.; et al. "PolyTB: A genomic variation map for Mycobacterium tuberculosis". Tuberculosis 94 3 (2014): 346-354. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900826220&partnerID=MN8TOARS. 10.1016/j.tube.2014.02.005 Coll, F.; McNerney, R.; Guerra-Assunção, J.A.; Glynn, J.R.; Perdigão, J.; Viveiros, M.; Portugal, I.; et al. "A robust SNP barcode for typing Mycobacterium tuberculosis complex strains". Nature Communications 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84907371489&partnerID=MN8TOARS. 10.1038/ncomms5812 Silva, C.; Perdigão, J.; Jordão, L.; Portugal, I.. "Mycobacterial interspersed repetitive unit typing and mutational profile for multidrug-resistant and extensively drug-resistant tuberculosis surveillance in Portugal: A 3-year period overview". International Journal of Antimicrobial Agents 44 6 (2014): 546-551. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911880610&partnerID=MN8TOARS. 10.1016/j.ijantimicag.2014.06.021 Perdigão, J.; Silva, H.; Machado, D.; Macedo, R.; Maltez, F.; Silva, C.; Jordao, L.; et al. "Unraveling genomic diversity and evolution in lisbon, portugal, a highly drug resistant setting". BMC Genomics 15 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84924032266&partnerID=MN8TOARS. 10.1186/1471-2164-15-991 Botelho, A.; Perdigão, J.; Canto, A.; Albuquerque, T.; Leal, N.; Macedo, R.; Portugal, I.; Cunha, M.V.. "Pre-multidrug-resistant mycobacterium tuberculosis beijing strain associated with disseminated tuberculosis in a pet dog". Journal of Clinical Microbiology 52 1 (2014): 354-356. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891383562&partnerID=MN8TOARS. 10.1128/JCM.02800-13 Perdigão, J.; Macedo, R.; Machado, D.; Silva, C.; Jordão, L.; Couto, I.; Viveiros, M.; Portugal, I.. "GidB mutation as a phylogenetic marker for Q1 cluster Mycobacterium tuberculosis isolates and intermediate-level streptomycin resistance determinant in Lisbon, Portugal". Clinical Microbiology and Infection 20 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84901592777&partnerID=MN8TOARS. 10.1111/1469-0691.12392 Silva, C.; Perdigao, J.; Alverca, E.; De Matos, A.P.A.; Carvalho, P.A.; Portugal, I.; Jordao, L.. "Exploring the contribution of mycobacteria characteristics in their interaction with human macrophages". Microscopy and Microanalysis 19 5 (2013): 1159-1169. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884550838&partnerID=MN8TOARS. 10.1017/S1431927613001906 Machado, D.; Perdigão, J.; Ramos, J.; Couto, I.; Portugal, I.; Ritter, C.; Boettger, E.C.; Viveiros, M.. "High-level resistance to isoniazid and ethionamide in multidrug-resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations". Journal of Antimicrobial Chemotherapy 68 8 (2013): 1728-1732. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880761362&partnerID=MN8TOARS. 10.1093/jac/dkt090 Perdigão, J.; Macedo, R.; Silva, C.; Machado, D.; Couto, I.; Viveiros, M.; Jordao, L.; Portugal, I.. "From multidrug-resistant to extensively drug-resistant tuberculosis in Lisbon, Portugal: The stepwise mode of resistance acquisition". Journal of Antimicrobial Chemotherapy 68 1 (2013): 27-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871220844&partnerID=MN8TOARS. 10.1093/jac/dks371 Machado, D.; Couto, I.; Perdigão, J.; Rodrigues, L.; Portugal, I.; Baptista, P.; Veigas, B.; Amaral, L.; Viveiros, M.. "Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis". PLoS ONE 7 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859513842&partnerID=MN8TOARS. 10.1371/journal.pone.0034538 Perdigão, J.; Macedo, R.; Silva, C.; Pinto, C.; Furtado, C.; Brum, L.; Portugal, I.. "Tuberculosis drug-resistance in Lisbon, Portugal: A 6-year overview". Clinical Microbiology and Infection 17 9 (2011): 1397-1402. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051868092&partnerID=MN8TOARS. 10.1111/j.1469-0691.2010.03351.x Veigas, B.; MacHado, D.; Perdigão, J.; Portugal, I.; Couto, I.; Viveiro, M.; Baptista, P.V.. "Au-nanoprobes for detection of SNPs associated with antibiotic resistance in Mycobacterium tuberculosis". Nanotechnology 21 41 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77958595642&partnerID=MN8TOARS. 10.1088/0957-4484/21/41/415101 Perdigão, João; Milho, Catarina; Carrilho, Lurdes; Brum, Laura; Portugal, Isabel. "Genotypic analysis of Mycobacterium tuberculosis isolates from a Lisbon hospital in Portugal". Revista Portuguesa de Pneumologia (English Edition) 15 5 (2009): 761-769. http://dx.doi.org/10.1016/s2173-5115(09)70153-8. 10.1016/s2173-5115(09)70153-8 Perdigão, J.; Milho, C.; Carrilho, L.; Brum, L.; Portugal, I.. "Genotypic analysis of Mycobacterium tuberculosis isolates from a Lisbon hospital in Portugal". Revista Portuguesa de Pneumologia 15 5 (2009): 761-769. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449715877&partnerID=MN8TOARS. Perdigão, J.; Macedo, R.; Malaquias, A.; Ferreira, A.; Brum, L.; Portugal, I.. "Genetic analysis of extensively drug-resistant Mycobacterium tuberculosis strains in Lisbon, Portugal". Journal of Antimicrobial Chemotherapy 65 2 (2009): 224-227. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950288031&partnerID=MN8TOARS. 10.1093/jac/dkp452 Perdigão, J.; Macedo, R.; Ribeiro, A.; Brum, L.; Portugal, I.. "Genetic characterisation of the ethambutol resistance-determining region in Mycobacterium tuberculosis: prevalence and significance of embB306 mutations". International Journal of Antimicrobial Agents 33 4 (2009): 334-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-61449095498&partnerID=MN8TOARS. 10.1016/j.ijantimicag.2008.09.021 Perdigão, J.; MacEdo, R.; João, I.; Fernandes, E.; Brum, L.; Portugal, I.. "Multidrug-resistant tuberculosis in Lisbon, Portugal: A molecular epidemiological perspective". Microbial Drug Resistance 14 2 (2008): 133-143. http://www.scopus.com/inward/record.url?eid=2-s2.0-50149104875&partnerID=MN8TOARS. 10.1089/mdr.2008.0798
Thesis / Dissertation	Perdigão, João. "Molecular and Genomic Epidemiology of Multidrug Resistant Mycobacterium tuberculosis Isolates in Lisbon, Portugal". PhD, 2013. Perdigão, João. "Tuberculose Multirresistente em Lisboa". Master, Universidade de Lisboa Faculdade de Ciências, 2008.

Award

2009	Award for the Best Oral Communication in the S2 Theme Symposium – Cell and Tissue Engineering, Biomaterials and Nanobiotechnologies Sociedade Portuguesa de Microbiologia, Portugal
2009	Award SPP SPP/SEPAR/Vitória FAES Pharma Sociedade Portuguesa de Pneumologia, Portugal