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Adriana Rodrigues is currently a Junior Researcher integrated in the group "Aging and Stress" from the Instituto de Investigação e Inovação em Saúde (i3S) and the Faculty of Medicine from the University of Porto (FMUP) and an invited assistant professor at Faculty of Nutrition and Food Sciences from the University of Porto (FCNAUP). Adriana Rodrigues initiated her scientific carrier at FMUP, as a research trainee developing her undergraduate thesis. After graduation in Biology from University of Évora in 2006, she pursued her studies, as an invited researcher in the FMUP, where she obtained her PhD degree in Biomedicine in September 2013. Her PhD thesis on ¿Melanocortin 5 Receptor Signaling Pathways: Implications on Adipocyte Biology", describes a novel role for the neuropeptides melanocortins in the regulation of lipid turnover and unravels the involvement of the melanocortin 5 receptor (MC5R) in this mechanism. Based on the development of different constructs of MC5R stably expressing GFP, she demonstrated that MC5R forms intracellular vesicles retaining signaling complexes in the cytoplasm and then recycle back to cell periphery to initiate another cycle of signaling; signal propagation to the nuclei pointed out the regulation of genes important for energy homeostasis. Naturally, she proceeded as postdoctoral researcher being able to uncover the transcriptional program activated in the adipocyte: for the first time the browning effect of melanocortins in white adipose tissue was described. Browning relates to the transdifferentiation of white adipocytes into a brown-like state able to convert lipids into heat. This is a very important anti-obesity mechanism as she demonstrated in her recent paper published in one of the most recognized journals in the obesity field, the International Journal of Obesity from the Nature Publishing Group. Overall, she published 24 papers in international peer reviewed journals, of these, 21 were original research articles, 3 were review articles and 10 were as first author. She is also author of 1 book-chapter and co-author of 31 conference papers. Her work was presented more than 90 times in several meetings both orally (38 times, 6 of which was as invited speaker) and in poster format (59). Her work has been recognized both national and internationally, as she was awarded with 3 best research work, 2 best poster presentations, 3 best oral communications and 3 travel awards. Besides she earned 2 FCT grants (Doctoral and PosDoc), 3 Obesity study grants from TANITA, ABBOTT and SPEDM and one FCT project. In addition, her PhD thesis was nominated for ¿Best Thesis Award¿ by the European Association for the Study of Obesity. Over the last years, Adriana Rodrigues has strengthened its expertise in the area of obesity and ageing as both share biological hallmarks related to a dysfunctional adipose tissue. Adipose inflammation and senescence stem from the pathological expansion of white adipose tissue and are now considered crucial risk factors for obesity/aging-related pathologies. The mechanism involved seems related to the adipose tissue crosstalk with other tissues and organs, and constitutes the focus of Adriana current studies. She has been active in academic activities in the FMUP, as well, being responsible for the supervision of 2 PhD student, 5 MSc students and 5 BSc students. She is also a lecturer in Gerontology sessions of MSc and PhD programs on Medicine and Molecular Oncology, and more recently in Neuronal cell culture module from MSc program on Neurobiology. She also participates in dissemination of knowledge activities promoted by UP Junior University since 2007. In 2019 she was hired by the Institute for Molecular and Cellular Biology from i3S as a Junior Researcher. Since 2022, she lectures Cellular and Molecular Biology at FCNAUP in parallel with her research activities.
Identification

Personal identification

Full name
Adriana Raquel Rodrigues

Citation names

  • Adriana Rodrigues
  • Adriana Raquel Rodrigues

Author identifiers

Ciência ID
9A10-756A-D96A
ORCID iD
0000-0002-9613-1552
Google Scholar ID
cX4wCDUAAAAJ
Researcher Id
Z-6004-2019
Scopus Author Id
25223739100

Email addresses

  • adrod@med.up.pt (Professional)

Telephones

Telephone
  • 225513654 (Professional)

Addresses

  • Alameda Hernâni Monteiro, CIM, piso 4, 4200-319, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences
  • Medical and Health Sciences - Basic Medicine
  • Medical and Health Sciences - Clinical Medicine - Endocrinology and Metabolism

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2017/05/08 - 2017/05/19
Concluded
FELASA - Laboratory Animal Science Course | Cat C (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/09/18
Concluded
Biomedicine (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"Melanocortin 5 receptor signalling pathways: implications on adipocyte biology" (THESIS/DISSERTATION)
Approved with distinction by unanimity
2006
Concluded
Biology (Licenciatura)
Major in Scientific
Universidade de Évora, Portugal
"Primary cultures of rat adrenal gland cells: in vitro study of ERK 1/2 signalling pathway" (THESIS/DISSERTATION)
16
Affiliation

Science

Category
Host institution
Employer
2019/01/01 - Current Contracted Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2014/01/01 - 2018/12/31 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
(...)
2012/01/01 - 2013/12/31 Researcher (Research) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2008/01/01 - 2011/12/31 Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
(...)
2006/09/01 - 2007/12/01 Researcher (Research) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2005/01/01 - 2006/07/12 Research Trainee (Research) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2022/09/01 - Current Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2014 - Current Lecturer (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal

Others

Category
Host institution
Employer
2012/01/01 - 2013/12/31 Professor of Biology and Biochemistry Instituto Português de Naturologia, Portugal
Projects

Grant

Designation Funders
2014/01/01 - 2018/12/31 Characterization of the melanocortins role on white adipocyte browning: a protection against obesity
SFRH/BPD/92868/2013
Post-doc Fellow
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2013/09/18 Melanocortin 5 Receptor Signaling Pathways: Implications on Adipocyte Biology
SFRH/BD/41024/2007
PhD Student Fellow
Universidade do Porto Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Instituto de Investigação e Inovação em Saúde
LA/P/0070/2020
UID/BIM/04293/2019
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023 - 2025 Impulso de la integración del ecossitema de I+I em salud euro regional para la adopción de soluciones avanzadas
0144_TRANSFIRESAUDE_1_E
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Agencia Gallega para la Gestión del conocimento en Salud, Spain
European Regional Development Fund
Ongoing
2022/01/01 - 2023/06/30 Exploring glycans as novel players in tumor-adipose tissue transdifferentiation and cancer cachexia (EXPL/MED-ONC/1001/2021)
EXPL/MED-ONC/1001/2021
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2022/12/31 Endometriosis - unravelling the intricate crosstalk among endometrium and adipose tissue in the search of novel therapeutic targets
Researcher
Universidade do Porto Faculdade de Medicina, Portugal

Centro Hospitalar Universitário de São João, Portugal
Sociedade Portuguesa de Ginecologia
2016/09/01 - 2020/08/31 Novel anti-obesity therapy: melanocortins induction of beige adipocytes
PTDC/BIM-MET/2123/2014
Universidade do Porto Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/09/01 - 2020/05/31 Novel anti-obesity therapy: melanocortins induction of beige adipocytes (PTDC/BIM-MET/2123/2014)
PTDC/BIM-MET/2123/2014
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2012 - 2013 Browning of Human White Adipocytes: Melanocortins as Essential Players
TANITA_2012
PhD Student Fellow
Universidade do Porto Faculdade de Medicina, Portugal
TANITA Healthy Weight Community Trust
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 2 - 2011-2012
PEst-C/SAU/LA0002/2011
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2012 Obesity: the role of melanocortins in adipose tissue
UP/Santander_2011
PhD Student Fellow
Universidade do Porto Faculdade de Medicina, Portugal
Banco Santander Totta

Universidade do Porto
Concluded
2010 - 2011 Obesity: The role of melanocortins in the adipocyte function
SPEDM/ABBOTT
PhD Student Fellow
Universidade do Porto Faculdade de Medicina, Portugal
SPEDM - Sociedade Portuguesa de Obesidade, Diabetes e Metabolismo

Abbott Laboratories SA
Concluded
2010 - 2011 The emerging role of melanocortins in adipocyte: from fat to facts
TANITA_2010
PhD Student Fellow
TANITA Healthy Weight Community Trust, Japan
TANITA Healthy Weight Community Trust
Concluded
2009 - 2010 Characterization of the expression of SIRT1, SIRT6 and SIRT7 in the human corpus cavernosum during ageing
Santander/UP_2009
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
Banco Santander Totta

Universidade do Porto
Concluded
2007 - 2008 Molecular study of vascular remodelling and VEGF-angiopoietins crosstalk in aged-related vasculogenic erectile dysfunction progression
CGD/UP
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
Caixa Geral de Depositos

Universidade do Porto
Concluded
2006 - 2007 Intracellular trafficking of the melanocortin 5 receptor (MC5-R) in the adrenal gland cells
Gulbenkian
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
Fundação Calouste Gulbenkian
Concluded

Other

Designation Funders
2015 - 2016 Modulatory effect of dietary pattern, exercise and atorvastatin treatment on eNos, sirtuins and miR-155 expression in the erectile tissue of the aged rat
n.a.
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
Concluded
Outputs

Publications

Book
  1. Miguel Mata Pereira; Professor Doutor Pedro Morato; Joel Santos; Ferreira, Marco; Adriana Raquel Rodrigues. Uma Casa da Praia em cada Escola - Educação e Saúde Mental Infantil. Lisboa, Portugal: Centro Doutor João dos Santos ¿ Casa da Praia. 2022.
    Published
Book chapter
  1. Rodrigues, Adriana; Salazar, Maria J.; Gouveia, Alexandra. "Obesity and Adipose Tissue Remodeling". In Understanding Obesity: From Its Causes To Impact On Life, edited by Rosário Monteiro; Maria João Martins, 55-80. Bentham Science Publishers, 2020.
    Published
Conference abstract
  1. A C Net. Cerqueira; Adriana Rodrigues; S Lamas; Alexandra Gouveia; Henrique Almeida; D. Neves. "Metformin: new therapeutic approach for endometriosis-associated infertility". 2021.
    10.1093/humrep/deab130.299
  2. Nadia Silva; Maria J. Salazar; Elisabete Silva; Delminda Neves; Henrique Almeida; Alexandra M Gouveia; Rodrigues, Adriana Raquel. "a-MSH reestablishes homeodynamics of obese adipose tissue by modulating cellular stress responses". Paper presented in 1st EUGLOH Annual Student Research Conference – Global Health Challenges: Diseases of Modern Life, Szeged, 2020.
    Published
  3. Nádia Silva; Maria J. Salazar; Elisabete Silva; Delminda Neves; Henrique Almeida; Alexandra M Gouveia; Rodrigues, Adriana Raquel. "Melanocortins repress stress-specific responses to attenuate oxidative damage of adipose tissue in obesity". Paper presented in 15th YES Meeting, Porto, 2020.
    Published
  4. Silva, Nádia; Salazar, Maria; Silva, Elisabete; Neves, Delminda; Almeida, Henrique; Gouveia, Alexandra; Rodrigues, Adriana Raquel. "Melanocortins act as stress-response modulators in adipose tissue of obese mice". Paper presented in IJUP 2020, Porto, 2020.
    Published
  5. Neto, Ana Catarina; Ribeiro, Ângela; Rodrigues, Adriana Raquel; Silva-Carvalho, João Luís; Almeida, Henrique; Neves, Delminda. "Specific microRNAs levels in Follicular Fluid as biomarkers for fertility outcome in endometriosis.". Paper presented in 7º Congresso Português de Medicina da Reprodução, Porto, 2019.
    Published
  6. Silva, Nádia; Salazar, Maria; Silva, Elisabete; Neves, Delminda; Almeida, Henrique; Gouveia, Alexandra; Rodrigues, Adriana Raquel. "a-MSH decreases cellular stress responses in ingWAT of obese mice". Paper presented in i3s meeting, Póvoa do Varzim, 2019.
    Published
  7. Rodrigues, Adriana Raquel; Salazar, Maria; Neves, Delminda; Almeida, H; Gouveia, Alexandra. "Novel protective role of melanocortins in obesity by modulating adipose tissue inflammation, fibrosis and stress-response mechanisms". Paper presented in EMBO workshop Organ crosstalk in energy balance and metabolic disease, Cadiz, 2019.
    Published
  8. Rodrigues, Adriana Raquel; Salazar, Maria; Silva, Elisabete; Neves, Delminda; Almeida, Henrique; Gouveia, Alexandra. "Ageing of adipose tissue: is there a role for melanocortins?". Paper presented in Ageing: models, mechanisms and therapies, Coimbra, 2019.
    Published
  9. Rodrigues, Adriana Raquel; Salazar, Maria; Rocha-Rodrigues, S; Gonçalves, Inês; Cruz, Célia; Almeida, Henrique; Magalhães, José; Gouveia, Alexandra. "Alpha-MSH enhances transdifferentiation of white into brown-like adipocytes in mice". Paper presented in EMBO Workshop - Brown adipose tissue, Sitges, 2017.
    Published
  10. Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Spatial and Temporal signalling of Melanocortin 5 Receptor: its putative role on lipolysis regulation". Paper presented in 6th International Melanocortin Meeting, Utrecht, 2010.
    Published
  11. Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Melanocortin 5 Receptor signalling through mitogen-activated protein kinase ERK 1/2". Paper presented in GPCR 2008 - structure function relationships of G-ptotein coupled receptors in the spotlight, Montpellier, 2008.
    Published
Conference paper
  1. Ana Catarina Neto; Adriana Raquel Rodrigues; Gouveia, Alexandra; Almeida, Henrique; Neves, Delminda. "Metformin reduces endometrial implants and improves fertility in a mouse model of endometriosis". Paper presented in 38th ESHRE Annual Meeting, Milan, 2022.
    Published • https://doi.org/10.1093/humrep/deac107.327
  2. Ana Catarina Neto; Adriana Raquel Rodrigues; Lamas, Sofia; Gouveia, Alexandra; Almeida, Henrique; Neves, Delminda. "300 Metformin: new therapeutic approach for endometriosis-associated infertility". Paper presented in 37th Eshre Annual Meeting, 2021.
    Published • https://doi.org/10.1093/humrep/deab130.299
  3. Silva, Nádia; Salazar, Maria; Silva, Elisabete; Neves, Delminda; Almeida, Henrique; Gouveia, Alexandra; Rodrigues, Adriana Raquel. "Beneficial effects of melanocortins on obesity-related metabolic dysfunction: a focus on the adipose tissue features of premature ageing". Paper presented in 11th Symposium on Metabolism, Porto, 2019.
    Published
  4. Timóteo-Ferreira, Filipa; Mendes, Sara; Rocha, AN; Rodrigues, Adriana Raquel; Matos, Liliana; Almeida, Henrique; Silva, Elisabete. "Specific antioxidant effect on ovarian ageing". Paper presented in 11th Symposium on Metabolism - Ageing&Metabolism, Porto, 2019.
    Published
  5. Mendes, Sara; Timóteo-Ferreira, Filipa; Rocha, AN; Matos, Liliana; Rodrigues, Adriana Raquel; Saraiva, J; Almeida, Henrique; Guedes-Martins, L; Silva, Elisabete. "Maternal uterine ageing and placentation". Paper presented in 11th Symposium on Metabolism - Ageing&Metabolism, Porto, 2019.
    Published
  6. Neto, C; Ribeiro, A; Rodrigues, Adriana Raquel; Silva-Carvalho, JL; Almeida, H; Neves, Delminda. "Analysis of mi20a_1, mi145_1 and 320a_1 levels in follicular fluid of endometriosis patients. Their role as putative biomarkers for outcome of assisted reproductive technology (ART)". Paper presented in 35th ESHRE Annual Meeting, Wien, 2019.
    Published • https://doi.org/10.1093/humrep/34.Supplement_1.1
  7. Salazar, Maria; Rodrigues, Adriana Raquel; Neves, Delminda; Almeida, H; Magalhaes, J; Gouveia, Alexandra. "Characterization of a-MSH browning effect in the distinct fat depots from obese and lean mice". Paper presented in 26th European Congress on Obesity, Glasgow, 2019.
    Published • doi.org/10.1159/000497797
  8. Rodrigues, Adriana Raquel; Salazar, Maria J.; Neves, D; Almeida, H; Gouveia, Alexandra. "The melanocortins against obesity-induced adipose tissue dysfunction: role in inflammation, fibrosis and stress response mechanisms". Paper presented in 26th European Congress on Obesity (ECO2019), Glasgow, 2019.
    Published • 10.1159/000497797
  9. Timóteo-Ferreira, Filipa; Mendes, Sara; Rocha, AN; Matos, Liliana; Rodrigues, Adriana Raquel; Almeida, H; Silva, Elisabete. "Improvement of the age-related ovarian involution by the use of a NADPH-oxidase inhibitor". Paper presented in 14th YES Meeting, Porto, 2019.
    Published • 10.1097/j.pbj.0000000000000054
  10. F. Timóteo-Ferreira; Sara Mendes; Natalina Alexandra Rocha; Matos, Liliana; Adriana Rodrigues; Henrique Almeida; Elisabete Silva. "Improvement of age-related ovarian involution by the use of a NADPH - oxidase inhibitor.". Paper presented in 14th YES Meeting, 2019.
    Published
  11. Silva, N.; Maria J. Salazar; Silva, Elisabete; Neves, Delminda; Almeida H; Gouveia, Alexandra; Adriana Raquel Rodrigues. "Beneficial effects of melanocortins on obesity-related metabolic dysfunction: a focus on the adipose tissue 10 features of premature ageing". Paper presented in 11th Symposium on Metabolism - Ageing & Metabolism, Porto, 2019.
    Published
  12. Salazar, Maria; Rodrigues, Adriana Raquel; Neves, Delminda; Almeida, Henrique; Magalhães, J; Gouveia, Alexandra. "Browning effect of the melanocortins among mice different adipose tissue depots". Paper presented in 10th Symposium on Metabolism, Porto, 2018.
    Published
  13. Timóteo-Ferreira, Filipa; Rocha, AN; Mendes, Sara; Rodrigues, Adriana Raquel; Matos, Liliana; Almeida, H; Silva, Elisabete. "Female reproductive aging: exploring the effects of antioxidant treatment". Paper presented in 13th YES Meeting, Porto, 2018.
    Published • 10.1016/j.pbj.0000000000000032
  14. Mendes, Sara; Timóteo-Ferreira, Filipa; Rodrigues, Adriana Raquel; Matos, Liliana; Saraiva, J; Almeida, H; Martins, Luis; Silva, Elisabete. "Uterine protein oxidative modifications as a contributor to defective placentation". Paper presented in 13th YES Meeting, Porto, 2018.
    Published • 10.1016/j.pbj.0000000000000032
  15. Rodrigues, Adriana Raquel; Salazar, Maria; Rocha-Rodrigues, Sílvia; Gonçalves, Inês; Cruz, Célia; Almeida, Henrique; Magalhães, José; Gouveia, Alexandra. "Alpha-MSH induces “browning” of subcutaneous white adipose tissue in mice". Paper presented in European Congress on Obesity (ECO2017), Porto, 2017.
    Published • 10.1159/000468958
  16. Pereira, AS; Rodrigues, Adriana Raquel; Rocha, B; Tomada, Nuno; Gouveia, Alexandra; Neves, Delminda. "Intervention of diabetes mellitus and metabolic risk factors in AMPK-PGC1a-SIRT3 pathway in the human corpus cavernosum". Paper presented in 12th YES Meeting, Porto, 2017.
    Published • 10.1016/j.pbj.2017.07.090
  17. Rodrigues, Adriana Raquel; Salazar, Maria; Moreira, A; Guimarães, M; Nora, M; Almeida, Henrique; Monteiro, M; Gouveia, Alexandra. "Akt/Smad3 signaling increases with adiposity and correlates to transforming growth factor b (TGF-b) levels in human adipose tissue". Paper presented in UMIB Summit 2015, Porto, 2016.
    Published • 10.1097/MD.0000000000002371
  18. Rodrigues, Adriana Raquel; Salazar, Maria; Moreira, A; Guimarães, M; Nora, M; Monteiro, Mariana; Almeida, Henrique; Gouveia, Alexandra. "Obesity correlates to an increased transforming growth factor ß (TGF-ß) in human visceral subcutaneous adipose tissue". Paper presented in European Congress on Obesity (ECO2015), Prague, 2015.
    Published • 10.1159/000382140
  19. Salazar, Maria; Rodrigues, Adriana Raquel; Rocha-Rodrigues, Sílvia; Gonçalves, I; Almeida, Henrique; Magalhães, J; Gouveia, Alexandra. "Browning of white adipocytes: melanocortins as essential players". Paper presented in UMIB Summit 2015, Porto, 2015.
    Published • 10.1097/MD.0000000000002371
  20. Moreira, A; Pereira, Sofia; Andrade, Sara; Rodrigues, Adriana Raquel; Santos, Madalena; Morais, Tiago; Gouveia, Alexandra; Monteiro, Mariana. "Prostate cancer cells are able to interact with surrounding adipocytes inducing phenotypic alterations that can promote tumor expansion". Paper presented in UMIB Summit 2015, Porto, 2015.
    Published • 10.1097/MD.0000000000002371
  21. Rodrigues, Adriana Raquel; Salazar, Maria; Almeida, H; Gouveia, Alexandra. "Melancortins as essential players on "Browning" of white adipocytes". Paper presented in XVI Congresso Português de Endocrinologia, Funchal, Madeira, 2015.
    Published • dx.doi.org/10.1016/j.rpedm.2014.12.012
  22. Rodrigues, Adriana Raquel; Almeida, Henrique; Gouveia, Alexandra. "Melanocortin’s role in the adipocyte lipid metabolism". Paper presented in European Congress on Obesity (ECO2014), Sofia, 2014.
    Published • 10.1159/000363667
  23. Sousa-Pinto, B; Gonçalves, L; Rodrigues, Adriana Raquel; Salazar, Maria; Tomada, I; Almeida, H; Neves, Delminda; Gouveia, Alexandra. "Dieta híper-lipídica e restrição energética associam-se a um aumento da expressão de TGF-ß no tecido adiposo do rato". Paper presented in 18º Portuguese Congress on Obesity, Aveiro, 2014.
    Published
  24. Salazar, Maria; Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "O papel das melanocortinas na diferenciação de adipócitos brancos em beges/castanhos". Paper presented in 18th Portuguese Congress on Obesity, Aveiro, 2014.
    Published
  25. Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Modulation of adipocyte fat mass by Melanocortin-5-Receptor". Paper presented in . XIII Congresso Português de Endocrinologia, Porto, 2013.
    Published
  26. Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Melanocortin 5 Receptor: a new player in lipid metabolism". Paper presented in XIII Congresso Português de Endocrinologia, Coimbra, 2012.
    Published
  27. Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Melanocortin-5-Receptor activation promotes lipolysis and impairs re-esterification in adipocytes". Lisboa, 2012.
    Published
  28. Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Melanocortin Signalling in fat cells". Paper presented in XI Congresso Português de Endocrinologia, Granja-Espinho, 2010.
    Published
  29. Sousa, Diana; Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Melanocortin 5 Receptor targeting to cell surface: the role of the N-terminus". Paper presented in YES Meeting, 2010.
    Published
  30. Rodrigues, Adriana Raquel; Pignatelli, D; Gouveia, Alexandra. "Unravelling the Melanocortin 5 Receptor signalling pathway". Paper presented in X Congresso Português de Endocrinologia, Vilamoura, 2009.
    Published
  31. Rodrigues, Adriana Raquel; Pignatelli, D; Gouveia, Alexandra. "Melanocortin 5 Receptor (MC5R) expression is regulated by a-MSH in rat adrenal cells". Paper presented in EXPERIMENTAL BIOLOGY, Washington, 2007.
    Published
Conference poster
  1. Ânia Gomes; Magalhães, Nisa; Beatriz Silva; Maria J. Salazar; Almeida, Henrique; Duarte, Tiago L; Silva, Elisabete; Gouveia, Alexandra; Adriana Raquel Rodrigues. "Iron overload in mice subcutaneous adipose tissue downregulates lipid metabolism and adipocyte browning". Paper presented in Yes meeting 2023, 2023.
  2. Ânia Gomes; Magalhães, Nisa; Beatriz Silva; Maria J. Salazar; Almeida, Henrique; Duarte, Tiago L; Silva, Elisabete; Gouveia, Alexandra; Adriana Raquel Rodrigues. "Lipid metabolism in iron overloaded mice adipose tissue". Paper presented in IJUP 2023, 2023.
  3. Beatriz Silva; Ânia Gomes; Magalhães, Nisa; Maria J. Salazar; Almeida, Henrique; Duarte, Tiago L; Matos, Liliana; et al. "The subcutaneous adipose tissue from HFE-knockout mice accumulates high levels of iron and develops a pro-inflammatory phenotype.". Paper presented in IJUP 2023, 2023.
  4. Botelho M, Rodrigues AR, Gouveia AM, Fernandes AS, Martinho M, Almeida H, Neto AC, Neves D.. "Characterization of PCNA, CYP17A1 and VEGF expression in eutopic and ectopic endometrium of endometriosis patients with advanced reproductive age.". Paper presented in ABC Days V Encontro Anual do Algarve Biomedical Center, subordinado ao tema Aging Challenges, 12-14 de Outubro 2022, Sagres, 2022.
  5. Adriana Guerreiro; Adriana Raquel Rodrigues; Elisabete Silva. "Ovulation and ovarian senescence as key drivers of ovarian aging". Paper presented in SPF Meeting 2022, 2022.
  6. Botelho M, Rodrigues AR, Gouveia AM, Fernandes AS, Martinho M, Almeida H, Neto AC, Neves D. "Immunofluorescence analysis of PCNA and cytochrome P450-17A1 expression in eutopic and ectopic endometrium of endometriosis patients.". Paper presented in 17th Yes Meeting Setembro 2022, Porto, 2022.
  7. Adriana Guerreiro ; Adriana Raquel Rodrigues; Elisabete Silva. "Ovarian aging and cellular senescence: an interspecies study". Paper presented in XVII CONGRESSO INTERNACIONAL VETERINÁRIO MONTENEGRO 2021, 2021.
  8. Ana Filipa Martins; Adriana Raquel Rodrigues; Delminda Neves. "Metformin mitigates cardiovascular risk in a mice model of endometriosis through downregulation of ET-1 and upregulation of eNOS expression". Paper presented in 16th Yes Meeting, 2021.
  9. Oliveira, Ricardo ; Maria J. Salazar; Liliana Matos; Adriana Raquel Rodrigues; Alexandra Gouveia. "In vitro assessment of copper capacity to induce cellular senescence and the protective role of a-MSH". Paper presented in IJUP’21 – 14º Encontro de Investigação Jovem da Universidade do Porto, 2021.
  10. Luísa Sousa; Adriana Raquel Rodrigues; Elisabete Silva. "Preliminary data on age-related oxidative modifications to uterine proteins". Paper presented in IJUP’21 – 14º Encontro de Investigação Jovem da Universidade do Porto, 2021.
  11. Rodrigo Felgueiras; Adriana Raquel Rodrigues; Delminda Neves. "Modulatory effect of Metformin on AMPK/Sirt1/PGC-1a/Sirt3 pathway in the heart of mouse model of endometriosis". Paper presented in IJUP 21 - 14º Encontro de Investigação Jovem da Universidade do Porto, 2021.
  12. Maria Botelho; Adriana Raquel Rodrigues; Delminda Neves. "Metformin effect in ectopic endometrium histological features in a mice-model of endometriosis.". Paper presented in IJUP 21 - 14º Encontro de Investigação Jovem da Universidade do Porto, 2021.
  13. Ricardo Oliveira; Gouveia, Alexandra; Adriana Raquel Rodrigues. "In vitro assessment of copper capacity to induce cellular senescence and the protective role of alpha-MSH.". Paper presented in IJUP 2021, 2021.
  14. Martins, AF; Neto, AC; Rodrigues, Adriana Raquel; Almeida, Henrique; Neves, Delminda. "Metformin effect on eNOS, iNOS, ET-1, VEGF and VEGFR-2 cardiac expression on a rodent experimental model of endometriosis". Paper presented in IJUP, 2020.
  15. Teixeira, AS; Abreu, D; Timóteo-Ferreira, Filipa; Gouveia, Alexandra; Almeida, Henrique; Rodrigues, Adriana Raquel; Silva, Elisabete. "Maternal ageing and placenta lipid metabolism: implications on foetal overgrowth". Paper presented in IJUP, 2020.
  16. Abreu, D; Teixeira, AS; Timóteo-Ferreira, Filipa; Rodrigues, Adriana; Silva, André; Almeida, H; Matos, Liliana; Silva, Elisabete. "Reproductive ovarian ageing: a comparison with the liver". Paper presented in IJUP, 2020.
  17. Felgueiras, R; Neto, AC; Rodrigues, Adriana; Almeida, Henrique; Neves, Delminda. "Effect of Metformin in the expression of SIRT1 and SIRT3 on the heart cells of mice with endometriosis". Paper presented in IJUP, 2020.
  18. Neto, AC; Ribeiro, Ângela; Rodrigues, Adriana Raquel; Silva-Carvalho, JL; Almeida, H; Neves, Delminda. "Analysis of mi20a_1, mi145_1 and 320a_1 levels in follicular fluid of endometriosis patients. Their role as putative biomarkers for outcome of assisted reproductive technology (ART)". Paper presented in 35th ESHRE Annual Meeting, 2019.
  19. Silva, Nádia; Salazar, Maria; Silva, Elisabete; Neves, Delminda; Almeida, Henrique; Gouveia, Alexandra; Rodrigues, Adriana Raquel. "a-MSH decreases cellular stress responses in ingWAT of obese mice". Paper presented in i3S meeting, 2019.
  20. Mendes, Sara; Timóteo-Ferreira, Filipa; Rodrigues, Adriana Raquel; Matos, Liliana; Saraiva, Joaquim; Almeida, H; Silva, Elisabete. "Maternal uterine ageing and placentation". Paper presented in 11th Symposium on Metabolism - Ageing&Metabolism, 2019.
  21. Martins, AF; Neto, AC; Rodrigues, Adriana Raquel; Almeida, H; Neves, Delminda. "Efeito da metformina na expressão de eNOS, iNOS, Endotelina 1, VEGF e VEGFR2 no coração de murganho com endometriose". Paper presented in XII Minho Medical Meeting, 2019.
  22. Rodrigues, Adriana Raquel; Salazar, Maria; Silva, Elisabete; Neves, Delminda; Almeida, Henrique; Gouveia, Alexandra. "Novel protective role of melanocortins in obesity by modulating adipose tissue inflammation, fibrosis and stress-response mechanisms". Paper presented in EMBO workshop - Organ crosstalk in energy balance and metabolic disease, 2019.
  23. Timóteo-Ferreira, Filipa; Rocha, NA; Mendes, Sara; Rodrigues, Adriana Raquel; Matos, Liliana; Almeida, Henrique; Silva, Elisabete. "Apocynin ameliorates age-related ovarian fertility decline in mice". Paper presented in Ageing: models, mechanisms and therapies, 2019.
  24. Rodrigues, Adriana Raquel. "Uterine ageing: protein carbonylation and placentation". Paper presented in Ageing: models, mechanisms and therapies, 2019.
  25. Rodrigues, Adriana Raquel; Salazar, Maria; Silva, Elisabete; Neves, Delminda; Almeida, H; Gouveia, Alexandra. "Ageing of adipose tissue: is there a role for melanocortins?". Paper presented in Ageing: models, mechanisms and therapies, 2019.
  26. Salazar, Maria; Rodrigues, Adriana Raquel; Neves, Delminda; Almeida, H; Magalhães, J; Gouveia, Alexandra. "Alpha-MSH browning effect in the diverse fat depots of obese and lean mice". Paper presented in EMBO workshop - Organ crosstalk in energy balance and metabolic disease., 2019.
  27. Timóteo-Ferreira, Filipa; Mendes, Sara; Rocha, NA; Rodrigues, Adriana Raquel; Matos, Liliana; Almeida, H; Silva, Elisabete. "Effects of antioxidant supplementation in female reproductive ageing". Paper presented in 7th i3S Annual Meeting, 2018.
  28. Mendes, Sara; Timóteo-Ferreira, Filipa; Rodrigues, Adriana Raquel; Matos, Liliana; Saraiva, J; Almeida, H; Guedes-Martins, L; Silva, Elisabete. "Uterine protein carbonylation may contribute to a defective placentation". Paper presented in 7th i3S Annual Meeting, 2018.
  29. Mendes, Sara; Timóteo-Ferreira, Filipa; Rodrigues, Adriana Raquel; Matos, Liliana; Saraiva, J; Almeida, H; Guedes-Martins, L; Silva, Elisabete. "Uterine protein oxidative modifications as a contributor to defective placentation". Paper presented in Yes Meeting, 2018.
  30. Rodrigues, Adriana Raquel; Salazar, Maria; Rocha-Rodrigues, Sílvia; Gonçalves, Inês; Cruz, Célia; Almeida, H; Magalhães, J; Gouveia, Alexandra. "Alpha-MSH enhances transdifferentiation of white into brown-like adipocytes in mice". Paper presented in EMBO Workshop - Brown adipose tissue, 2017.
  31. Rocha, Bárbara; Rodrigues, Adriana Raquel; Tomada, I; Gouveia, Alexandra; Almeida, H; Neves, Delminda. "A Role for Dietary Pattern, Physical Exercise and Atorvastatin Treatment in the expression of Sirtuins 1-7 in Aged Rat’s Corpus Cavernous". Paper presented in Yes meeting, 2016.
  32. Rocha, Bárbara; Rodrigues, Adriana Raquel; Tomada, I; Gouveia, Alexandra; Almeida, H; Neves, Delminda. "Effect of dietary pattern, exercise and atorvastatin treatment on iNOS and Endothelin-1 expression on aged rat’s cavernous tissue". Paper presented in IJUP, 2016.
  33. Salazar, Maria; Rodrigues, Adriana Raquel; Rocha-Rodrigues, Sílvia; Gonçalves, Inês; Almeida, H; Magalhães, J; Gouveia, Alexandra. "Browning of white adipocytes: melanocortin as essential players". Paper presented in UMIB Summit, 2015.
  34. Salazar, Maria; Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Melanocortins as essential players on "Browning” of white adipocytes". Paper presented in XVI Congresso Português de Endocrinologia, 2015.
  35. Moreira, A; Pereira, SS; Andrade, S; Rodrigues, Adriana Raquel; Santos, M; Morais, T; Gouveia, Alexandra; Monteiro, MP. "Prostate cancer cells are able to interact with surrounding adipocytes inducing phenotypic alterations that can promote tumor expansion". Paper presented in UMIB Summit, 2015.
  36. Rodrigues, Adriana Raquel; Salazar, Maria; Almeida, H; Gouveia, Alexandra. "Browning of white adipocytes: melanocortin as essential players". Paper presented in Yes meeting, 2015.
  37. Rodrigues, Adriana Raquel; Salazar, Maria; Moreira, A; Guimarães, M; Nora, M; Almeida, H; Monteiro, MP; Gouveia, Alexandra. "Obesity correlates to an increased transforming growth factor ß (TGF-ß) in human visceral subcutaneous adipose tissue". Paper presented in 22nt European Congress on Obesity (ECO2015), 2015.
  38. Salazar, Maria; Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Melanocortins as essential players on "Browning” of white adipocytes". Paper presented in IJUP, 2015.
  39. Salazar, Maria; Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Browning” of white adipocytes: melanocortins as essential players". Paper presented in 4th i3S meeting, 2014.
  40. Rodrigues, Adriana Raquel; Salazar, Maria; Almeida, H; Gouveia, Alexandra. "Melanocortin’s role in the adipocyte lipid metabolism". Paper presented in 21st European Congress on Obesity (ECO 2014), 2014.
  41. Sousa-Pinto, Bernardo; Gonçalves, L; Rodrigues, Adriana Raquel; Salazar, Maria; Tomada, I; Almeida, H; Gouveia, Alexandra. "Dieta híper-lipídica e restrição energética associam-se a um aumento da expressão de TGF-ß no tecido adiposo do rato". Paper presented in 18º Congresso Português de Obesidade, 2014.
  42. Salazar, Maria; Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "O papel das melanocortinas na diferenciação de adipócitos brancos em beges/castanhos". Paper presented in 18º Congresso Português de Obesidade, 2014.
  43. Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Melanocortin 5 Receptor regulates lipolysis in 3T3-L1 adipocytes". Paper presented in i3S scientific retreat - III edition, 2012.
  44. Sousa, D; Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Importance of Amino terminus for Melanocortin 5 Receptor trafficking and signaling". Paper presented in 17th National Congress of Biochemistry, 2010.
  45. Sousa, D; Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "N-terminus specific domains of the Melanocortin 5 Receptor are responsible for targeting to cell surface". Paper presented in YES Meeting, 2010.
  46. Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "The melanocortin 5 receptor signaling in adipocytes". Paper presented in I3S scientific retreat, 2010.
  47. Rodrigues, Adriana; Almeida, H; Gouveia, Alexandra. "Spatial and Temporal signalling of Melanocortin 5 Receptor: its putative role on lipolysis regulation". Paper presented in 6th International Melanocortin Meeting, 2010.
  48. Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "The emerging role of melanocortins in obesity: from fat to facts". Paper presented in 13rd Portuguese Congress of Obesity, 2009.
  49. Tomada, N; Figueiredo, A; Cordeiro, AL; Rodrigues, Adriana Raquel; Gouveia, Alexandra; Almeida, H; Gouveia, Alexandra. "Quantitative study of angiopoietins and Tie-2: expression in human erectile tissue during aging by real-time PCR". Paper presented in CURy - The 2nd World Congress on Controversies in Urology, 2009.
  50. Cordeiro, AL; Figueiredo, A; Rodrigues, Adriana Raquel; Gouveia, Alexandra; Almeida, H; Neves, Delminda. "Molecular study of vascular remodelling and VEGF-angiopoietins crosstalk in aged-related vasculogenic erectile dysfunction progression". Paper presented in IJUP, 2009.
  51. Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Melanocortin 5 receptor (MC5R) activates ERK1/2 through a PI3K-dependent mechanism". Paper presented in IBMC second scientific retreat, 2009.
  52. Sousa, D; Rodrigues, Adriana; Almeida, H; Gouveia, Alexandra. "Função do N-terminal do Receptor 5 das Melanocortinas no tráfego celular". Paper presented in III Jornadas de Ciências do Instituto Superior de Ciências da Saúde - Norte subordinadas ao tema Ciência: a causa das coisas, 2009.
  53. Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Melanocortin 5 Receptor activation induces CREB and c-Fos signalling". Paper presented in SINAL 09, 2009.
  54. Rodrigues, Adriana; Almeida, H; Gouveia, Alexandra. "Melanocortin-5 receptor activates MAP kinase signaling pathway". Paper presented in SINAL 2008, 2008.
  55. Rodrigues, Adriana Raquel; Almeida, H; Gouveia, Alexandra. "Melanocortin 5 Receptor signalling through mitogen-activated protein kinase ERK 1/2". Paper presented in GPCR 2008 - structure function relationships of G-ptotein coupled receptors in the spotlight, 2008.
  56. Figueiredo, A; Cordeiro, AL; Tomada, N; Rodrigues, Adriana Raquel; Gouveia, Alexandra; Almeida, H; Neves, Delminda. "Real-time PCR quantitative study of angiopoietins and Tie-2 expression in human erectile tissue during ageing". Paper presented in III YES Meeting, 2008.
  57. Neves, Delminda; Tomada, I; Rodrigues, Adriana Raquel; Figueiredo, A; Cordeiro, AL; Tomada, N; Gouveia, Alexandra; Almeida, H. "Intake of nutritionally defined diets crosstalk with ageing in endothelial dysfunction". Paper presented in LINK-AGE Working Research Group B, 2008.
  58. Rodrigues, Adriana Raquel; Luís, M; Seabra, F; Matos, Liliana; Neves, Delminda; Almeida, H. "Morphological changes and Bax expression in adrenocortical cells exposed to endotoxin". Paper presented in 2007 LINK-AGE Meeting- The Free Radical Theory of Ageing-50 years and beyond-a tribute to Denham Harman, 2007.
  59. Rodrigues, Adriana Raquel; Pignatelli, D; Gouveia, Alexandra. "Melanocortin 5 Receptor (MC5R) expression is regulated by alpha-MSH in rat adrenal cells". Paper presented in Experimental Biology Annual Meeting, 2007.
Journal article
  1. Ricardo Oliveira; Maria Salazar; Liliana Matos; Henrique Almeida; Adriana Rodrigues; Alexandra Gouveia. "High copper levels induce premature senescence in 3T3-L1 preadipocytes". BBA - Molecular Cell Research (2024): https://doi.org/10.1016/j.bbamcr.2024.119734.
    Published • 10.1016/j.bbamcr.2024.119734
  2. Preza-Fernandes J; Passos P; Mendes-Ferreira M; Rodrigues AR; Gouveia AM; Fraga A; Medeiros R; Ribeiro R. "A hint for the obesity paradox and the link between obesity, perirenal adipose tissue and Renal Cell Carcinoma progression.". Scientific reports (2022): https://europepmc.org/articles/PMC9675816.
    10.1038/s41598-022-24418-9
  3. Ana Filipa Martins; Ana Catarina Neto; Adriana Raquel Rodrigues; Sandra Marisa Oliveira; Cláudia Sousa-Mendes; Adelino Leite-Moreira; Alexandra Maria Gouveia; Henrique Almeida; Delminda Neves. "Metformin Prevents Endothelial Dysfunction in Endometriosis through Downregulation of ET-1 and Upregulation of eNOS". Biomedicines (2022): https://doi.org/10.3390/biomedicines10112782.
    10.3390/biomedicines10112782
  4. Rodrigo Felgueiras; Neto AC; Rodrigues AR; Gouveia AM; Almeida H; Delminda Neves. "Anti-oxidant effect of metformin through AMPK/SIRT1/PGC-1a/SIRT3- independent GPx1 expression in the heart of mice with endometriosis.". Hormone molecular biology and clinical investigation (2022): https://doi.org/10.1515/hmbci-2022-0039.
    10.1515/hmbci-2022-0039
  5. F. Timóteo-Ferreira; D. Abreu; S. Mendes; L. Matos; A.R. Rodrigues; H. Almeida; E. Silva. "Redox imbalance in age-related ovarian dysfunction and perspectives for its prevention". Ageing Research Reviews 68 (2021): 101345-101345. https://doi.org/10.1016/j.arr.2021.101345.
    10.1016/j.arr.2021.101345
  6. Salazar, Maria; Rodrigues, Adriana Raquel; Mafalda, S; Magalhães, J; Neves, Delminda; Almeida, H; Gouveia, Alexandra (2C15-98D1-4FA9). "Characterization of a-MSH browning effect in diverse mice white adipose tissue depots". Journal of Molecular Endocrinology 66 1 (2021): 23-34. https://doi.org/10.1530/JME-20-0002.
    Published • doi: 10.1530/JME-20-0002
  7. Mendes, S.; Timóteo-Ferreira, F.; Soares, A.I.; Rodrigues, A.R.; Silva, A.M.N.; Silveira, S.; Matos, L.; et al. "Age-related oxidative modifications to uterine albumin impair extravillous trophoblast cells function". Free Radical Biology and Medicine 152 (2020): 313-322. http://dx.doi.org/10.1016/j.freeradbiomed.2020.03.020.
    Published • 10.1016/j.freeradbiomed.2020.03.020
  8. Pereira, AS; Gouveia, Alexandra; Tomada, Nuno; Rodrigues, Adriana Raquel; Neves, Delminda. "Cumulative Effect of Cardiovascular Risk Factors on Regulation of AMPK/SIRT1-PGC-1a-SIRT3 Pathway in the Human Erectile Tissue". Oxidative Medicine and Cellular Longevity (2020): https://doi.org/10.1155/2020/1525949.
    Published • 10.1155/2020/1525949
  9. F. Timóteo-Ferreira; S. Mendes; N. A. Rocha; L. Matos; A. R. Rodrigues; H. Almeida; E. Silva. "Apocynin Dietary Supplementation Delays Mouse Ovarian Ageing". Oxidative Medicine and Cellular Longevity 2019 (2019): 1-11. https://doi.org/10.1155/2019/5316984.
    Published • 10.1155/2019/5316984
  10. Rodrigues, Adriana; Salazar, Maria; Rocha-Rodrigues, Sílvia; Gonçalves, Inês O.; Cruz, Célia; Neves, Delminda; Almeida, Henrique; Magalhães, José; Gouveia, Alexandra. "Peripherally administered melanocortins induce mice fat browning and prevent obesity". International Journal of Obesity 43 5 (2019): 1058-1069. http://dx.doi.org/10.1038/s41366-018-0155-5.
    Published • 10.1038/s41366-018-0155-5
  11. Rodrigues, Adriana. "Energy restriction, exercise and atorvastatin treatment improve endothelial dysfunction and inhibit miRNA-155 in the erectile tissue of the aged rat.". Nutrition & metabolism (2018): http://europepmc.org/articles/PMC5902942.
    10.1186/s12986-018-0265-z
  12. Rodrigues, A.R.; Sousa, D.; Almeida, H.; Gouveia, A.M.. "Cell surface targeting of the Melanocortin 5 Receptor (MC5R) requires serine-rich terminal motifs". Biochimica et Biophysica Acta - Molecular Cell Research 1864 7 (2017): 1217-1226. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018609533&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2017.04.004
  13. Sousa-Pinto, B.; Gonçalves, L.; Rodrigues, A.R.; Tomada, I.; Almeida, H.; Neves, D.; Gouveia, A.M.. "Characterization of TGF-ß expression and signaling profile in the adipose tissue of rats fed with high-fat and energy-restricted diets". Journal of Nutritional Biochemistry 38 (2016): 107-115. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991503722&partnerID=MN8TOARS.
    10.1016/j.jnutbio.2016.07.017
  14. Rodrigues, A.R.; Almeida, H.; Gouveia, A.M.. "Intracellular signaling mechanisms of the melanocortin receptors: Current state of the art". Cellular and Molecular Life Sciences 72 7 (2015): 1331-1345. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930912702&partnerID=MN8TOARS.
    10.1007/s00018-014-1800-3
  15. Freitas, M.; Rodrigues, A.R.; Tomada, N.; Fonseca, J.; Magalhães, A.; Gouveia, A.M.; Neves, D.. "Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum". Journal of Sexual Medicine 12 11 (2015): 2141-2152. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955198153&partnerID=MN8TOARS.
    10.1111/jsm.13035
  16. Fonseca, J.; Tomada, N.; Magalhães, A.; Rodrigues, A.R.; Gouveia, A.M.; Neves, D.. "Effect of aging and cardiovascular risk factors on receptor tie1 expression in human erectile tissue". Journal of Sexual Medicine 12 4 (2015): 876-886. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926420589&partnerID=MN8TOARS.
    10.1111/jsm.12794
  17. Rodrigues, A.R.; Sousa, D.; Almeida, H.; Gouveia, A.M.. "Structural determinants regulating cell surface targeting of melanocortin receptors". Journal of Molecular Endocrinology 51 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884620346&partnerID=MN8TOARS.
    10.1530/JME-13-0055
  18. Rodrigues, A.R.; Almeida, H.; Gouveia, A.M.. "a-MSH signalling via melanocortin 5 receptor promotes lipolysis and impairs re-esterification in adipocytes". Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1831 7 (2013): 1267-1275. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877661657&partnerID=MN8TOARS.
    10.1016/j.bbalip.2013.04.008
  19. Rodrigues, A.R.; Almeida, H.; Gouveia, A.M.. "Melanocortin 5 receptor signaling and internalization: Role of MAPK/ERK pathway and ß-arrestins 1/2". Molecular and Cellular Endocrinology 361 1-2 (2012): 69-79. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864359242&partnerID=MN8TOARS.
    10.1016/j.mce.2012.03.011
  20. Figueiredo, A.; Cordeiro, A.L.; Tomada, N.; Tomada, I.; Rodrigues, A.; Gouveia, A.; Neves, D.. "Real-time pcr study of Ang1, Ang2, Tie-2, VEGF, and KDR expression in human erectile tissue during aging". Journal of Sexual Medicine 8 5 (2011): 1341-1351. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955144117&partnerID=MN8TOARS.
    10.1111/j.1743-6109.2010.02116.x
  21. Adriana Raquel Rodrigues; Almeida, Henrique; Gouveia, Alexandra. "Obesidade: O Papel das Melanocortinas na regulacao da Homeostasia Energetica". Rev. Port. Endoc. Diab Metab 6 1 (2011): 76-86.
    Published
  22. Rodrigues, A. R.; Almeida, H.; Gouveia, A. M.. "Structural insights on melanocortin 5 receptor targeting to cell surface". Microscopy and Microanalysis 15 S3 (2009): 3-4. http://dx.doi.org/10.1017/s143192760999047x.
    Published • 10.1017/s143192760999047x
  23. Rodrigues, A.R.; Pignatelli, D.; Almeida, H.; Gouveia, A.M.. "Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signaling mechanism". Molecular and Cellular Endocrinology 303 1-2 (2009): 74-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-62949102680&partnerID=MN8TOARS.
    10.1016/j.mce.2009.01.014
  24. Rodrigues, A.R.; Gouveia, A.M.; Ferreira, J.G.; Almeida, H.. "ACTH induces ERK 1/2 activation in rat adrenal primary cultures". Microscopy and Microanalysis 14 SUPPL. 3 (2008): 101-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-53349175612&partnerID=MN8TOARS.
    10.1017/S1431927608089526
Thesis / Dissertation
  1. Rodrigues, Adriana Raquel. "Melanocortin 5 receptor signaling pathways: implications on adipocyte biology". PhD, Universidade do Porto Faculdade de Medicina, 2013. https://hdl.handle.net/10216/70507.
  2. Rodrigues, Adriana Raquel. "Primary cultures of rat adrenal glands: in vitro study of ERK1/2 signaling pathway". Degree, Universidade de Évora, 2006.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/09/16 Copper induction of senescence in 3T3-L1 preadipocytes and the potential protective role of a-MSH 16th Yes Meeting, 16-19 Setembro 2021
(Porto, Portugal)
2021/05/05 Metformin treatment downregulates ET-1 and VEGF expression in the heart of an endometriosis mice-model IJUP 21 - 14º Encontro de Investigação Jovem da Universidade do Porto
University of Porto (Porto, Portugal)
2020/09/28 a-MSH reestablishes homeodynamics of obese adipose tissue by modulating cellular stress responses. 1st EUGLOH Annual Student Research Conference – Global Health Challenges: Diseases of Modern Life
University of Szeged (Hungary)
2020/09/17 Melanocortins repress stress-specific responses to attenuate oxidative damage of adipose tissue in obesity 15th YES Meeting
University of Porto/Faculty of Medicine (Portugal)
2020 Melanocortins act as stress-response modulators in adipose tissue of obese mice 13 th Meeting of Young Researchers of University of Porto
Universidade do porto (Porto, Portugal)
2019/10/30 Beneficial effects of melanocortins on obesity-related metabolic dysfunction: a focus on the adipose tissue features of premature ageing 11st symposium on Metagolism – Ageing&Metabolism
Universidade do Porto Faculdade de Medicina (Porto, Portugal)
2019/05/28 The melanocortins against obesity-induced adipose tissue dysfunction: role in inflammation, fibrosis and stress response mechanisms 26th European Congress on Obesity (ECO2019)
European Association for the study of obesity (Glasgow, United Kingdom)
2019/05 Specific microRNAs levels in Follicular Fluid as biomarkers for fertility outcome in endometriosis 7º Congresso Português de Medicina da Reprodução
(Porto, Portugal)
2019 Specific antioxidant effect on ovarian ageing 11st symposium on Metagolism - Ageing&Metabolism
Universidade do Porto Faculdade de Medicina (Porto, Portugal)
2019 Improvement of the age-related ovarian involution by the use of a NADPH-oxidase inhibitor 14th Yes Meeting
(Porto, Portugal)
2019 Characterization of a-MSH browning effect in the distinct fat depots from obese and lean mice 26th European Congress on Obesity (ECO2019)
(Glawgow, United Kingdom)
2018 Adipose tissue browning in obese and lean mice: the effect of the melanocortins in the distinct fat depots i3S 7th Annual Meeting
i3S (Porto, Portugal)
2018 Browning effect of the melanocortins among mice different adipose tissue depots 10th Symposium on Metabolism
Universidade do Porto Faculdade de Medicina (Porto, Portugal)
2018 Female reproductive aging: exploring the effects of antioxidant treatment Yes Meeting 2018
Young European Scientist (porto, Portugal)
2017/07/05 The melanocortin “browning" effect on adipose tissue: when darkness is a light for obesity DBM meeting
Universidade do Porto Faculdade de Medicina (Porto, Portugal)
2017 Browning of white adipose tissue in the context of obesity 21º Congresso Português de Obesidade
Sociedade Portuguesa para o estudo da obesidade (Aveiro, Portugal)
2017 White-to-brown transdifferentiation of mice adipose tissue by melanocortins: a challenging therapy for obesity i3S 6th Annual Meeting
i3S (Póvoa do Varzim, Portugal)
2017 Alpha-MSH induces “browning” of subcutaneous white adipose tissue in mice 24st European Congress on Obesity
European Society of obesity (Porto, Portugal)
2017 Dual effect of anti-oxidant treatment on reproductive aging i3S 6th Annual Meeting
i3S (Póvoa do Varzim, Portugal)
2016 Effect of Dietary Pattern, Exercise and Atorvastatin Treatment on eNOS, iNOS and Endothelin-1 Expression in the Erectile Tissue of the Aged Rat Sociedade Portuguesa de Microscopia
Sociedade Portuguesa de Microscopia (Porto, Portugal)
2015 Expression of TGF-beta in different adipose tissue depots is singularly regulated by a high-fat diet and energy restriction IJUP 2015
Universidade do Porto (Porto, Portugal)
2015 Akt/Smad3 signaling increases with adiposity and correlates to transforming growth factor ß (TGF-ß) levels in human adipose tissue UMIB Summit 2015
Universidade do Porto (Porto, Portugal)
2014 Melanocortin 5 receptor signaling pathways: Implications on adipocyte biology 21st European Congress on Obesity
European Society for obesity (Sofia, Bulgaria)
2014 Modelo Celular de Obesidade Escola Superior de Saúde do Porto
(Porto, Portugal)
2014 O sistema melanocortina e Obesidade 18º Congresso Português de Obesidade
Sociedade portuguesa para o estudo da obesidade (Aveiro, Portugal)
2013 A hope for obesity? The role of melanocortins in adipocyte biology FMUP Seminars
(Porto, Portugal)
2013 Modulation of adipocyte fat mass by melanocortin 5 receptor XIV Congresso Português de Endocrinologia
Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo (Porto, Portugal)
2012 Melanocortin 5 Receptor: a new player in lipid metabolism XIII Congresso Português de Endocrinologia
Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo (Coimbra, Portugal)
2012 Melanocortin-5-Receptor activation promotes lipolysis and impairs re-esterification in adipocytes 16º Congresso Português de Obesidade
Sociedade portuguesa para o estudo da obesidade (Lisboa, Portugal)
2011 MC5R function in adipocyte lipid metabolism 1st Encontro de estudantes de doutoramento
Universidade do Porto Faculdade de Medicina (Porto, Portugal)
2010 The Role of Melanocortins in Adipocytes: from Fat to Facts BIT Life Sciences' 3rd annual PepCon-2010
(Beijing, China)
2010 Melanocortin signalling in fat cells I Congresso Português de Endocrinologia
Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo (Granja-Espinho, Portugal)
2009 Unravelling the Melanocortin 5 Receptor signalling pathway X Congresso Português de Endocrinologia
Sociedade de Endocrinologia, Diabetes e Metabolismo (Vilamoura, Portugal)
2009 Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signaling mechanism FMUP seminars
Universidade do Porto Faculdade de Medicina (Porto, Portugal)
2008 Melanocortin 5 Receptor signalling: ERK 1/2 activation through a PI3K-dependent mechanism INCOMMAM´08-International Conference on Microscopy and Microanalysis
Portuguese Society for Microscopy (Porto, Portugal)
2008 Intake of nutritionally defined diets crosstalk with ageing in endothelial dysfunction LINK-AGE Satellite Working Research Group B Meeting
NH Conference Centre Leeuwenhorst (Netherlands)
2007 Effects of endotoxin in adrenocortical cells YES Meeting 07
Young European Scientist Meeting (Porto, Portugal)
2007 Adrenocorticotropic Hormone Induces ERK 1/2 Activation in Rat Adrenal Primary Cultures INCOMMAM´07-International Conference on Microscopy and Microanalysis
Portuguese Society for Microscopy (Coimbra, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2020/09/01 - Current Understanding the role of Obesity and Adipose Tissue in the pathogenesis of COVID-19
Co-supervisor
Biomedicine (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2023/09/01 - 2027/08/31 Modulating FAT-organ crosstalk: the therapeutic potential of adipose-derived EVs in obesity
Supervisor
Doctoral Program of Metabolism - Clinics and Experimentation (PDMCE) (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2023/09/01 - 2025/08/31 Lipid metabolism in iron overloaded adipose tissue
Supervisor
Master in Molecular Medicine and Oncology (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2023/02/01 - 2023/06/30 The crosstalk between iron deposition and adipose tissue dysfunction
Supervisor
Licenciatura em Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2023/03/01 - 2023/06/01 Effects of iron overload in the adipocyte lipid metabolism
Supervisor
Licenciatura em Biotecnologia Medicinal (Degree)
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
2019/09/01 - 2021/12/17 Copper induction of senescence in 3T3-L1 preadipocytes and the role of a-MSH
Co-supervisor
Medicina e Oncologia Molecular (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2020/06 - 2021/07 Study of oxidative modifications to uterine proteins and their role in placentation.
Co-supervisor
Biologia (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2019/08/07 - 2020/11/16 Adipose tissue dysfunction in obesity: modulation of cellular stress responses by melanocortins
Supervisor
Biologia Celular e Molecular (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2019/09/01 - 2020/07 Effect of ageing and redox homeostasis on foetal overgrowth
Co-supervisor
Biologia (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2019/01/09 - 2020/01 The role of adipose tissue in the pathogenesis of endometriosis: benefits of metformin
Supervisor
Biologia (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2019/08/16 - 2020 Cumulative effect of cardiovascular risk factors on regulation of AMPK/SIRT1-PGC-1a-SIRT3 pathway in the human erectile tissue
Co-supervisor
Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2017/09/04 - 2019/06/14 Role of oxidative stress as modulator of quality preservation of stem cells from umbilical cord blood
Co-supervisor
Medicina e Oncologia Molecular (Master)
Universidade do Porto Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2019 - Current Organization of 11th Symposium on Metabolism - Ageing&Stress (2019)
Symposium (Member of the Organising Committee)
Universidade do Porto Faculdade de Medicina, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2007 - Current Participation as proponent and collaborator in the annual UP program "Escola das Ciências da Vida e da Saúde"
Workshop
Escola das Ciências da Vida e da Saúde
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2007 - 2009 Participation as monitor in the annual UP program "Universidade Júnior"
Workshop
Universidade Júnior
Universidade do Porto Faculdade de Medicina, Portugal

Association member

Society Organization name Role
2009/09/30 - Current Sociedade Portuguesa para o estudo de Obesidade
2008/12/09 - Current Sociedade Portuguesa de Obesidade, Diabetes e Metabolismo

Committee member

Activity description
Role
Institution / Organization
2019 - Current Organizing Committee of the 11th Symposium on Metabolism
Member
Universidade do Porto Faculdade de Medicina, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/09/01 - Current Cellular and Molecular Biology Ciências da Nutrição (Licenciatura) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2019 - Current Neuronal cell culture module Neurobiologia (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2014 - Current Biogerontology Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2014 - Current Gerontology I Medicina e Oncologia Molecular (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2014 - Current Gerontology II Medicina e Oncologia Molecular (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2012/01/01 - 2013/12/01 Biology and Biochemistry (Curso Técnico Superior Profissional) Instituto Português de Naturologia, Portugal
2007 - 2007 Cell Signaling Medicina e Oncologia Molecular (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2007 - 2007 Basic techniques of Molecular Biology Medicina e Oncologia Molecular (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2024 - 2024 Frontiers in Endocrinology (1664-2392) Frontiers Media
2023 - 2023 International Journal of Environmental Research and Public Health (1660-4601) MDPI
2022 - 2022 Biomolecules (2218-273X) MDPI
2022 - 2022 horticulturae (2311-7524) MDPI
2022 - 2022 International Journal of Molecular Sciences (1422-0067) MDPI
2022 - 2022 Nutrients (2072-6643) MDPI
2021 - 2021 Frontiers in Endocrinology (1664-2392) Frontiers Media
2019 - 2019 Oxidative Medicine and Cellular Longevity (1942-0994) Hindawi
2019 - 2019 Oxidative Medicine and Cellular Longevity (1942-0994) Hindawi
2016 - 2016 Cellular and Molecular Life Sciences (1420-682X) Springer Nature
2015 - 2015 Cellular and Molecular Life Sciences (1420-682) Springer Nature

Other jury / evaluation

Activity description Institution / Organization
2018/10/01 - Current Jury in session poster of Symposium on Metabolism Universidade do Porto Faculdade de Medicina, Portugal
2018/09 - Current Jury member (arguer) of the MSc's research project of the student Filipa Timóteo Ferreira in her 1st year of Master Degree in Medicine and Molecular Oncology, within the curricular unit "Preparation of the Dissertation"; thesis entitled: Female fertility decline: exploring the role of antioxidants in delaying ovarian ageing Universidade do Porto Faculdade de Medicina, Portugal
2019/04/24 - 2019/04/24 Jury member (arguer) of the Meeting-Interview of the doctoral student Carlos José Costa de Pinho in his 2nd year of the PhD programme in Medicine and Molecular Oncology; thesis entitled: Fat transfer analysis in distinct breast cancer reconstruction approaches Universidade do Porto Faculdade de Medicina, Portugal
2015/07 - 2015/07 Jury member (arguer) of the MSc's research project of the student Bárbara Sofia Ferreira da Rocha in her 1st year of Master Degree in Medicine and Molecular Oncology, within the curricular unit "Preparation of the Dissertation";thesis entitled: Modulatory effect of dietary pattern, exercise and atorvastatin treatment on eNos, sirtuins and miR-155 expression in the erectile tissue of the aged rat Universidade do Porto Faculdade de Medicina, Portugal
Distinctions

Award

2020 Best oral communication in Health Science
IJUP scientific committee, Portugal
2020 Best Oral communication
EUGLOH scientific committee, Hungary
2019 Travel grant
European Molecular Biology Organization, Germany
2019 Best poster presentation
Universidade do Minho Escola de Medicina, Portugal
2018 Best oral communication
Universidade do Porto Faculdade de Medicina, Portugal
2016 Best Oral communication
Sociedade Portuguesa de Microscopia, Portugal
2015 Travel Grant
European Association for the Study of Obesity, United Kingdom
2015 Best fundamental research work
SPEDM - Sociedade Portuguesa de Obesidade, Diabetes e Metabolismo, Portugal
2014 Best communication in Basic and Translational Research
Sociedade portuguesa para o estudo da obesidade, Portugal
2014 Nomination for the “Young Investigators United Best Thesis Award”
European Association for the Study of Obesity, United Kingdom
2014 Travel Grant
European Association for the Study of Obesity, United Kingdom
2013 Obesity Study Grant
TANITA Healthy Weight Community Trust, Japan
2012 Best fundamental research work
SPEDM - Sociedade Portuguesa de Obesidade, Diabetes e Metabolismo, Portugal
2011 Obesity Study Grant
TANITA Healthy Weight Community Trust, Japan
2010 1st Prize Poster Post-Graduate Presentation
Young European Scientist) Meeting, Portugal
2010 Obesity Study Grant
Abbott Laboratories SA, Spain

SPEDM - Sociedade Portuguesa de Obesidade, Diabetes e Metabolismo, Portugal
2009 Best fundamental research
SPEDM - Sociedade Portuguesa de Obesidade, Diabetes e Metabolismo, Portugal