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Federico Matias Issoglio obtained is Chemist degree in 2006/12/14 at Universidad Nacional de Córdoba, in the field of Biological Chemistry. He completed the PhD in 2014/09/04 at Centro de Investigaciones en Quimica Biológica de Córdoba (CIQUIBIC-CONICET) and Departamento de Química Biológica (Universidad Nacional de Córdoba - UNC). During this period he worked with enzymes involved in the biosynthesis of proteoglycogen, performing biochemical, biophysical and structural assays. In 2015 Federico was granted with a Postdoc position at Insituto de Química Física de los Materiales, Medio Ambiente y Energía (INQUIMAE-CONICET) and Facultad de Ciencias Exactas, Universidad de Buenos Aires (FCEN-UBA), under the supervision of Dr. Dario Estrin. For almost 4 years Federico studied proteins using computational tools, acquiring expertise in quantum chemistry, molecular dynamics simulations, molecular docking and free energy calculations. The main project involved the study of protein post-translational modifications through redox mechanisms, in collaboration with Dr. Rafael Radi (Universidad de la República). Moreover, several collaborations were carried out in diverse topics (some of those are still ongoing projects). In 2018 Federico obtained a position as a Researcher at Consejo Nacional de Investigaciones Científicas y Técnicas (IQUIBICEN-CONICET), joining the group of Dr. Marcelo Martí at Departamento de Química Biológica (FCEN-UBA). By combining the experimental and computational skills, the projects focused on the reactions and products of reactive nitrogen and oxygen species (ROS/RNOS) with Mycobacterium tubeculosis proteins. Currently, He is a Postdoc at Universidade Nova de Lisboa (Instituto de Tecnologia Química e Biológica - ITQB) where he joined the Membrane Protein Crystallography group, under the supervision of Prof. Margarida Archer. Here, Federico is studying membrane proteins form Mycobacterium tuberculosis, by determining the 3D structure using X-ray crystallography and/or cryo-electron microscopy, exploring the reactivity, and thus unraveling the mechanisms underlying its catalysis. Dr. Federico Issoglio PhD published 9 articles in indexed journals, participated in more than 20 scientific meetings, taught in laboratory courses from 2007 to 2015 at Universidad Nacional de Córdoba, and from 2016 to 2018 at University of Buenos Aires , and advised undergraduate and graduate students.
Identification

Personal identification

Full name
Federico Matias Issoglio

Citation names

  • Issoglio, FM

Author identifiers

Ciência ID
9A14-B846-9906
ORCID iD
0000-0001-9225-7855

Telephones

Mobile phone
  • 911901162 (Personal)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Exact Sciences - Physical Sciences - Chemical Physics
  • Exact Sciences - Chemical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Spanish; Castilian (Mother tongue)
English Intermediate (B1) Proficiency (C2) Advanced (C1) Proficiency (C2) Advanced (C1)
Italian Elementary (A2) Elementary (A2) Beginner (A1) Intermediate (B1) Beginner (A1)
Portuguese Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Advanced (C1) Intermediate (B1)
Education
Degree Classification
2008/10/01 - 2014/09/04
Concluded
Doctorado en Química (Doktor (PhD))
Centro de Investigaciones en Quimica Biológica de Córdoba Área de Investigación Química Biológica, Argentina
"Structural and biochemical studies of enzymes and reactions of de novo biosinthesys of Proteoglycogen." (THESIS/DISSERTATION)
2000/03/01 - 2006/12/14
Concluded
Licenciado en Química (Licence)
Universidad Nacional de Córdoba, Departamento de Química Biológica, Argentina
"MUTATIONAL ANALYSIS OF THE T-ANTIGEN BINDING SITE OF AGARICUS BISPORUS LECTIN" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution
Employer
2019/09/03 - Current Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa, Portugal
2018/11/01 - Current Researcher (Research) Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina
Universidad de Buenos Aires Facultad de Ciencias Exactas y Naturales, Argentina
2015/03/01 - 2018/10/31 Postdoc (Research) Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina
Universidad de Buenos Aires Facultad de Ciencias Exactas y Naturales, Argentina
Outputs

Publications

Journal article
  1. Samuel L. Freeman; Vera Skafar; Hanna Kwon; Alistair J. Fielding; Peter C.E. Moody; Alejandra Martínez; Federico Issoglio; et al. "Crystal Structure of Trypanosoma cruzi Heme Peroxidase and Characterisation of its Substrate Specificity and Compound I Intermediate". Journal of Biological Chemistry (2022): 102204-102204. https://doi.org/10.1016/j.jbc.2022.102204.
    10.1016/j.jbc.2022.102204
  2. "Crystal structure and mutational analysis of the human TRIM7 B30.2 domain provide insights into the molecular basis of its binding to glycogenin-1". Journal of Biological Chemistry 296 (2021): 100772-100772. http://dx.doi.org/10.1016/j.jbc.2021.100772.
    10.1016/j.jbc.2021.100772
  3. Pedron, F. N.; Issoglio, F.; Estrin, D. A.; Scherlis, D. A.. "Electron transfer pathways from quantum dynamics simulations". The Journal of Chemical Physics 153 22 (2020): 225102. http://dx.doi.org/10.1063/5.0023577.
    10.1063/5.0023577
  4. Issoglio, Federico. "Structure and function of crocodilian hemoglobins and allosteric regulation by chloride, ATP and CO2.". American journal of physiology. Regulatory, integrative and comparative physiology (2020): https://doi.org/10.1152/ajpregu.00342.2019.
    10.1152/ajpregu.00342.2019
  5. Issoglio, Federico. "3-Nitrotyrosine and related derivatives in proteins: precursors, radical intermediates and impact in function.". Essays in biochemistry (2020): https://doi.org/10.1042/EBC20190052.
    10.1042/ebc20190052
  6. Issoglio, Federico. "Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP).". Proceedings of the National Academy of Sciences of the United States of America (2017): https://europepmc.org/articles/PMC5338437.
    10.1073/pnas.1618611114
  7. Issoglio, Federico. "Exploring the Catalytic Mechanism of Human Glutamine Synthetase by Computer Simulations.". Biochemistry (2016): https://doi.org/10.1021/acs.biochem.6b00822.
    10.1021/acs.biochem.6b00822
  8. Issoglio, Federico. "Mechanisms of Monomeric and Dimeric Glycogenin Autoglucosylation". Journal of Biological Chemistry (2012): http://dx.doi.org/10.1074/jbc.m111.287813.
    10.1074/jbc.m111.287813
  9. Issoglio, Federico. "Structural and biochemical insight into glycogenin inactivation by the glycogenosis-causing T82M mutation.". FEBS letters (2012): https://doi.org/10.1016/j.febslet.2011.12.028.
    10.1016/j.febslet.2011.12.028
  10. Issoglio, Federico. "Evidence for glycogenin autoglucosylation cessation by inaccessibility of the acquired maltosaccharide.". Biochemical and biophysical research communications (2008): https://doi.org/10.1016/j.bbrc.2008.07.114.
    10.1016/j.bbrc.2008.07.114
  11. Issoglio, Federico. "The intramolecular autoglucosylation of monomeric glycogenin". Biochemical and Biophysical Research Communications (2008): http://dx.doi.org/10.1016/j.bbrc.2008.04.076.
    10.1016/j.bbrc.2008.04.076
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2021/10/01 - Current Structure-based drug design to fight tuberculosis and understand drug resistance mechanisms
Co-supervisor
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/08/02 - 2018/12/18 Study of ATP and bicarbonate binding on mammal hemoglobins
Supervisor
Laboratorio de Química (Research thesis to obtain Chemist degree) (Degree)
Universidad de Buenos Aires Facultad de Ciencias Exactas y Naturales, Argentina

Mentoring / Tutoring

Topic Student name
2018/10/25 - Current Computational study of the structure-function relationship of tetrameric hemoglobins Martin Pettinati
2018/03/21 - Current Drug development for the inhibition of the enzyme Glutamine Synthetase of Mycobacterium tuberculosis. Benjamin Storni