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Carlos Palmeira, is Full Professor in the Department of Life Sciences, University of Coimbra, Portugal and PI at Center for Neurosciences and Cell Biology, from the same University. His research interests are focused on the pathophysiological mechanisms of mitochondrial dysfunction and human health, with particular expertise in the study of the role of mitochondrial dysfunction in the pathogenesis of hepatic diseases and ischemia/reperfusion. He is a member of several national/international societies, and serves as Associate Editor in the journals Toxicology and Applied Pharmacology and Toxicology Mechanisms and Methods, being member of the Editorial Board in several other journals. He is author/co-author of more than 120 papers. He received his Ph.D in Biochemistry at the University of Coimbra, Portugal and postdoctoral training in biochemical toxicology at the University of Minnesota, Duluth, USA.
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Identification

Personal identification

Full name
Carlos Palmeira

Citation names

  • Palmeira, Carlos
  • Palmeira, Carlos M.

Author identifiers

Ciência ID
9C17-78E6-DA25
ORCID iD
0000-0002-2639-7697

Telephones

Telephone
  • (+351) 239240700 (Professional)

Addresses

  • DEPARTAMENTO DE CIÊNCIAS DA VIDA, Universidade de Coimbra, Colégio de S. Bento, Calçada Martim de Freitas, 3000-456, Coimbra, Coimbra, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Toxicology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Intermediate (B1) Advanced (C1) Intermediate (B1) Advanced (C1) Intermediate (B1)
Spanish; Castilian Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2010/02
Concluded
 Biociências (Título de Agregado)
Major in Biologia Celular e Molecular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1995/01/13
Concluded
 Bioquímica (Doutoramento)
Major in Toxicologia Bioquímica
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Alterações Metabólicas em Células Hepáticas de Rato Induzidas por Herbicidas de Uso Generalizado " (THESIS/DISSERTATION)
1989/09
Concluded
 Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Affiliation

Science

Category
Host institution 		Employer
1997 - Current Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1995/02/01 - 1997/03/31 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Minnesota, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2012/09/03 - Current Full Professor (University Teacher) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2006/03/01 - 2012/09/03 Associate Professor (University Teacher) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
1997/04/01 - 2006/03/01 Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Others

Category
Host institution 		Employer
2010/11 - 2012/11 Diretor do Departamento de Ciências da Vida Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2008 - 2009 Diretor do Departamento de Zoologia Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2002 - 2004 Diretor do Departamento de Zoologia Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2000 - 2002 Diretor do Departamento de Zoologia Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Projects

Contract

Designation Funders
2018 - Current FRUITIFY - Use of blueberry juice as a nutraceutical strategy targeting gut dysbiosis to prevent the progression from prediabetes to diabetes
PTDC/SAU-NUT/31712/2017 | POCI-01-0145-FEDER-031712
Researcher
Universidade de Coimbra Faculdade de Medicina, Portugal
Ongoing
2016/03 - 2019/12 A INTERAÇÃO ENTRE cAMP E SIRTUÍNAS COMO UM MECANISMO DE CONTROLO MITOCONDRIAL E METABÓLICO
PTDC /BIM-MEC / 6911 / 2014
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Secretaria de Estado de Ciência Tecnologia e Ensino Superior
Concluded
2016 - 2019 EXERCITANDO O FUTURO: Exercício voluntário durante diabetes gestacional com uma estratégia para melhorar a função mitocondrial na descendência.
PTDC /DTP-DES / 1082 / 2014
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2013/03 - 2014/02 Chronic effects of silver nanoparticles (AgNPs) on rat liver, kidney and heart mitochondrial function
FA8655-13-1-3036
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 EOARD
Concluded
2010 - 2013 ALTERAÇÕES NAS VIAS FISIOLÓGICAS E MECANISMOS MOLECULARES REGULADORES DA HOMEOSTASE ENERGÉTICA NA OBESIDADE E SÍNDROME METABÓLICO: IDENTIFICAÇÃO DE NOVAS ESTRATÉGIAS E ALVOS TERAPÊUTICOS
PTDC /SAU-NEU / 102612 / 2008
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2011/09 - 2012/08 ABILITY OF A MITOCHONDRIAL IMPROVER, BERBERINE, TO ATTENUATE PARKINSON´S DISEASE
RRIA 2011
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Michael J Fox Foundation for Parkinson's Research
Concluded
2010/03 - 2012/08 BENEFÍCIOS DO CONTROLO METABÓLICO PRECOCE: PREVENÇÃO DA FORMAÇÃO DE MEMÓRIA HIPERGLICÉMICA ATRAVÉS DA ESTIMULAÇÃO DA BIOENERGÉTICA.
PTDC /QUI-BIQ / 103514 / 2008
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Concluded
2007/09 - 2010/12 ALTERAÇÕES NAS VIAS FISIOLÓGICAS E MECANISMOS MOLECULARES REGULADORES DA HOMEOSTASE ENERGÉTICA NA OBESIDADE E SÍNDROME METABÓLICO: IDENTIFICAÇÃO DE NOVAS ESTRATÉGIAS E ALVOS TERAPÊUTICOS.
PTDC /SAU-OSM / 72443 / 2006
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Concluded
2008/01 - 2010/01 MODULAÇÃO DAS VIAS METABÓLICAS ENVOLVIDAS NO STRESS OXIDATIVO MITOCONDRIAL EM CONDIÇÕES DE HIPERGLICÉMIA: SUA RELEVÂNCIA NA PREVENÇÃO DA DIABETES
PTDC /QUI / 72826 / 2006
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Concluded
2007/06 - 2008/07 IN VITRO ASSESSMENT OF SILVER NANOPARTICLES TOXICITY IN HEPATIC MITOCHONDRIAL FUNCTION
FA8655-07-1-3047
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 EOARD
Concluded
2002/06 - 2005/07 COLESTASE E ESTEATOSE HEPÁTICA: TERAPIA COM ÁCIDOS BILIARES. MECANISMOS CELULARES COM RELEVÂNCIA NA FUNÇÃO MITOCONDRIAL.
POCTI /CBO / 42486 / 2001
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Concluded
2004/05 - 2004/11 13C NMR ISOTOPOMER ANALYSIS OF INTERMEDIARY METABOLISM IN A ADRIAMYCIN HEART FAILURE MODEL
1774-602-6050-7901
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 National Heart Lung and Blood Institute
Concluded
2001 - 2002 FUNÇÃO MITOCONDRIAL NO CÉREBRO E CORAÇÃO DE RATOS MODELO DE DIABETES MELLITUS NÃO DEPENDENTE DE INSULINA (GOTO-KAKIZAKI)
SAPIENS 43642 / 99
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
1998 - 2000 ISQUEMIA MIOCÁRDICA: ACÇÃO DE FÁRMACOS. IMPORTÂNCIA DA FUNÇÃO MITOCONDRIAL
PRAXIS / PSAU / P / SAU / /6/96
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
1997 - 2000 ISQUEMIA E DIABETES: ESTUDO COMPARATIVO DAS ALTERAÇÕES METABÓLICAS EM RATOS GK (UM MODELO GENÉTICO DE DIABETES NÃO DEPENDENTE DE INSULINA E EM RATOS WISTAR (MODELO)
PRAXIS/PSAU/P/SAU/1 /96
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
1996 - 2000 RASTREIO EXPERIMENTAL DA BIOTOXICIDADE: TECNOLOGIAS IN VITRO ALTERNATIVAS AOS TESTES ANIMAIS.
PRAXIS /2 / 2.2/BIO / 1156 / 95
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
1992 - 1995 TOXICOLOGIA APLICADA DE PESTICIDAS: ALTERAÇÕES FUNCIONAIS DE HEPATÓCITOS E SEUS MITOCÔNDRIOS
PBIC /C / BIO / 1159 / 92
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
Outputs

Publications

Book
  1. Palmeira, C.M.; Moreno, A.J.. Preface. 2018.
  2. Teodoro, J.S.; Duarte, F.V.; Rolo, A.P.; Palmeira, C.M.. Mitochondria as a Target for Safety and Toxicity Evaluation of Nutraceuticals. 2016.
    10.1016/B978-0-12-802147-7.00028-0
  3. Palmeira, C.M.; Rolo, A.P.. Preface. 2014.
  4. Palmeira, C.M.; Rolo, A.P.. Mitochondrial Regulation: Methods and Protocols. 2014.
    10.1007/978-1-4939-1875-1
Book chapter
  1. Teodoro, João Soeiro; Rolo, Anabela Pinto; Palmeira, Carlos Manuel Marques. "Mitochondrial Bioenergetic Assays as a Standard Protocol for Toxicological and Metabolic Assessment". In Methods in Molecular Biology, 231-241. Springer US, 2021.
    10.1007/978-1-0716-1091-6_16
  2. Teodoro, João S.; Machado, Ivo F.; Castela, Ana C.; Rolo, Anabela P.; Palmeira, Carlos M.. "The Evaluation of Mitochondrial Membrane Potential Using Fluorescent Dyes or a Membrane-Permeable Cation (TPP+) Electrode in Isolated Mitochondria and Intact Cells". In Methods in Molecular Biology, 197-213. Springer US, 2020.
    10.1007/978-1-0716-0802-9_14
  3. Alexandrino, H.; Rolo, A.; Tralhão, J.G.; Castro e Sousa, F.; Palmeira, C.; Alexandrino, Henrique; Rolo, Anabela; et al. "Mitochondria in liver regeneration: Energy metabolism and posthepatectomy liver dysfunction". In Mitochondrial Biology and Experimental Therapeutics, 127-152. Springer International Publishing, 2018.
  4. Teodoro, J.S.; Palmeira, C.M.; Rolo, A.P.; Palmeira CM; Rolo AP. "Mitochondrial membrane potential (¿¿) fluctuations associated with the metabolic states of mitochondria". 109-119. 2018.
    10.1007/978-1-4939-7831-1_6
  5. Teodoro, João Soeiro; Palmeira, Carlos Marques; Rolo, Anabela Pinto. "Mitochondrial Membrane Potential (¿¿) Fluctuations Associated with the Metabolic States of Mitochondria". In Methods in Molecular Biology, 109-119. Springer New York, 2018.
    10.1007/978-1-4939-7831-1_6
  6. Amorim, Joao Alves; Teodoro, Joao Soeiro; Palmeira, Carlos Marques; Rolo, Anabela Pinto. "Sirtuins and Bile Acids: Potential Anti-obesity Strategies Targeting Mitochondria". In Anti-Obesity Drug Discovery and Development: Volume 4, 57-97. BENTHAM SCIENCE PUBLISHERS, 2018.
    10.2174/9781681085586118040005
  7. Palmeira, C.M.; Ramalho-Santos, J.. "Mitochondrial dysfunction in reproductive and developmental toxicity". 1023-1035. 2017.
    10.1016/B978-0-12-382032-7.10061-X
  8. Teodoro, João S.; Duarte, Filipe V.; Rolo, Anabela P.; Palmeira, Carlos M.. "Mitochondria as a Target for Safety and Toxicity Evaluation of Nutraceuticals". In Nutraceuticals, 387-400. Elsevier, 2016.
    10.1016/b978-0-12-802147-7.00028-0
  9. Duarte, Filipe V.; Palmeira, Carlos M.; Rolo, Anabela P.; Duarte FV; Palmeira CM; Rolo AP. "The Emerging Role of MitomiRs in the Pathophysiology of Human Disease". In Advances in Experimental Medicine and Biology, 123-154. Springer International Publishing, 2015.
    10.1007/978-3-319-22671-2_8
  10. Teodoro, J.S.; Palmeira, C.M.; Rolo, A.P.; Teodoro JS; Palmeira CM; Rolo AP; Teodoro, João S.; Palmeira, Carlos M.; Rolo, Anabela P.. "Determination of oxidative phosphorylation complexes activities". In Methods in Molecular Biology, 71-84. Springer New York, 2014.
    10.1007/978-1-4939-1875-1_7
  11. Palmeira, Carlos M.; Duarte, Filipe V.; Teodoro, João S.; Varela, Ana T.; Rolo, Anabela P.; Palmeira, C.M.; Duarte, F.V.; et al. "Biomarkers of mitochondrial dysfunction and toxicity". In Biomarkers in Toxicology, 847-861. Elsevier, 2014.
    10.1016/b978-0-12-404630-6.00051-8
  12. Palmeira, Carlos M.; Rolo, Anabela P.. "Mitochondrial Membrane Potential (¿¿) Fluctuations Associated with the Metabolic States of Mitochondria". In Methods in Molecular Biology, 89-101. Humana Press, 2011.
    10.1007/978-1-61779-382-0_6
Edited book
  1. Palmeira, Carlos M.. Mitochondrial Bioenergetics. Springer New York. 2018.
    10.1007/978-1-4939-7831-1
  2. Palmeira, Carlos M.. Mitochondrial Regulation. Springer New York. 2015.
    10.1007/978-1-4939-1875-1
  3. Palmeira, Carlos M.. Mitochondrial Bioenergetics. Humana Press. 2012.
    10.1007/978-1-61779-382-0
Journal article
  1. Yang, Jae-Hyun; Hayano, Motoshi; Griffin, Patrick T.; Amorim, João A.; Bonkowski, Michael S.; Apostolides, John K.; Salfati, Elias L.; et al. "Loss of epigenetic information as a cause of mammalian aging". Cell 187 5 (2024): 1312-1313. http://dx.doi.org/10.1016/j.cell.2024.01.049.
    10.1016/j.cell.2024.01.049
  2. Panagiota-Efstathia Nikolaou; George Lambrinidis; Maria Georgiou; Dimitrios Karagiannis; Panagiotis Efentakis; Pavlos Bessis-Lazarou; Konstantina Founta; et al. "Hydrolytic Activity of Mitochondrial F1FO-ATP Synthase as a Target for Myocardial Ischemia–Reperfusion Injury: Discovery and In Vitro and In Vivo Evaluation of Novel Inhibitors". Journal of Medicinal Chemistry (2023): https://doi.org/10.1021/acs.jmedchem.3c01048.
    10.1021/acs.jmedchem.3c01048
  3. Ivo F. Machado; Raul G. Miranda; Daniel J. Dorta; Anabela P. Rolo; Carlos M. Palmeira. "Targeting Oxidative Stress with Polyphenols to Fight Liver Diseases". Antioxidants (2023): https://doi.org/10.3390/antiox12061212.
    10.3390/antiox12061212
  4. Cátia R. Lopes; Joana S. Silva; Joana Santos; Matilde S. Rodrigues; Daniela Madeira; Andreia Oliveira; Ana Moreira-de-Sá; et al. "Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/8/6968.
    10.3390/ijms24086968
  5. Ivo F. Machado; Carlos M. Palmeira; Anabela P. Rolo. "Preservation of Mitochondrial Health in Liver Ischemia/Reperfusion Injury". Biomedicines (2023): https://doi.org/10.3390/biomedicines11030948.
    10.3390/biomedicines11030948
  6. Yang, Jae-Hyun; Hayano, Motoshi; Griffin, Patrick T.; Amorim, João A.; Bonkowski, Michael S.; Apostolides, John K.; Salfati, Elias L.; et al. "Loss of epigenetic information as a cause of mammalian aging". Cell 186 2 (2023): 305-326.e27. http://dx.doi.org/10.1016/j.cell.2022.12.027.
    10.1016/j.cell.2022.12.027
  7. Raquel G. Bardallo; Rui T. Da Silva; Teresa Carbonell; Carlos Palmeira; Emma Folch-Puy; Joan Roselló-Catafau; René Adam; Arnau Panisello-Rosello. "Liver Graft Hypothermic Static and Oxygenated Perfusion (HOPE) Strategies: A Mitochondrial Crossroads". International Journal of Molecular Sciences 23 10 (2022): 5742-5742. https://doi.org/10.3390/ijms23105742.
    10.3390/ijms23105742
  8. "The Use of a Single, Novel Preservation Solution in Split Liver Transplantation and Hypothermic Oxygenated Machine Perfusion". Transplantation 106 3 (2022): e187-e188.
    Published
  9. João S. Teodoro; Rui T. Da Silva; Ivo F. Machado; Arnau Panisello-Roselló; Joan Roselló-Catafau; Anabela P. Rolo; Carlos M. Palmeira. "Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria". Cells 11 4 (2022): 688-688. https://doi.org/10.3390/cells11040688.
    10.3390/cells11040688
  10. Amorim, João A.; Coppotelli, Giuseppe; Rolo, Anabela P.; Palmeira, Carlos M.; Ross, Jaime M.; Sinclair, David A.. "Mitochondrial and metabolic dysfunction in ageing and age-related diseases". Nature Reviews Endocrinology (2022): http://dx.doi.org/10.1038/s41574-021-00626-7.
    10.1038/s41574-021-00626-7
  11. Rui Teixeira da Silva; Ivo F. Machado; João S. Teodoro; Arnau Panisello-Roselló; Joan Roselló-Catafau; Anabela P. Rolo; Carlos M. Palmeira. "PEG35 as a Preconditioning Agent against Hypoxia/Reoxygenation Injury". International Journal of Molecular Sciences 23 3 (2022): 1156-1156. https://doi.org/10.3390/ijms23031156.
    10.3390/ijms23031156
  12. Rui Teixeira Da Silva; Raquel G. Bardallo; Emma Folch-Puy; Teresa Carbonell; Carlos M. Palmeira; Constantino Fondevila; René Adam; Joan Roselló-Catafau; Arnau Panisello-Roselló. "IGL-2 as a Unique Solution for Cold Static Preservation and Machine Perfusion in Liver and Mitochondrial Protection". Transplantation Proceedings 54 1 (2022): 73-76. https://doi.org/10.1016/j.transproceed.2021.10.008.
    10.1016/j.transproceed.2021.10.008
  13. Sara Nunes; Sofia D. Viana; Inês Preguiça; André Alves; R. Fernandes; Teodoro, J.S.; Patrícia Matos; et al. "Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics". Nutrients (2021): https://www.mdpi.com/2072-6643/13/12/4192.
    10.3390/nu13124192
  14. Teodoro, João S.; Machado, Ivo F.; Castela, Ana C.; Amorim, João A.; Jarak, Ivana; Carvalho, Rui A.; Palmeira, Carlos M.; Rolo, Anabela P.. "Chenodeoxycholic Acid Has Non-Thermogenic, Mitodynamic Anti-Obesity Effects in an In Vitro CRISPR/Cas9 Model of Bile Acid Receptor TGR5 Knockdown". International Journal of Molecular Sciences 22 21 (2021): 11738. http://dx.doi.org/10.3390/ijms222111738.
    10.3390/ijms222111738
  15. Piochi, Luiz F.; Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P.. "Sestrin2 and mitochondrial quality control: Potential impact in myogenic differentiation". Ageing Research Reviews 67 (2021): 101309. http://dx.doi.org/10.1016/j.arr.2021.101309.
    10.1016/j.arr.2021.101309
  16. Oliveira, Raúl P.; Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P.. "The potential role of sestrin 2 in liver regeneration". Free Radical Biology and Medicine 163 (2021): 255-267. http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.027.
    10.1016/j.freeradbiomed.2020.12.027
  17. Machado, Ivo F.; Teodoro, João S.; Castela, Ana C.; Palmeira, Carlos M.; Rolo, Anabela P.. "miR-378a-3p Participates in Metformin’s Mechanism of Action on C2C12 Cells under Hyperglycemia". International Journal of Molecular Sciences 22 2 (2021): 541. http://dx.doi.org/10.3390/ijms22020541.
    10.3390/ijms22020541
  18. Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Figueirinha, Artur; et al. "Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicits Transcriptomics Reprogramming in Healthy Wistar Rats". Pharmaceutics 12 11 (2020): 1094. http://dx.doi.org/10.3390/pharmaceutics12111094.
    10.3390/pharmaceutics12111094
  19. João S. Teodoro; Rui Silva; António Aguiar; Abílio J. F. N. Sobral; Anabela P. Rolo; Carlos M. Palmeira. "Exploration of the cellular effects of the high-dose, long-term exposure to coffee roasting product furan and its by-product cis-2-butene-1,4-dial on human and rat hepatocytes". Toxicology Mechanisms and Methods 30 7 (2020): 536-545. https://doi.org/10.1080/15376516.2020.1780361.
    10.1080/15376516.2020.1780361
  20. Teodoro, João S.; Amorim, João A.; Machado, Ivo F.; Castela, Ana C.; Steegborn, Clemens; Sinclair, David A.; Rolo, Anabela P.; Palmeira, Carlos M.. "The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function". International Journal of Molecular Sciences 21 14 (2020): 4896. http://dx.doi.org/10.3390/ijms21144896.
    10.3390/ijms21144896
  21. Makrecka-Kuka, M.; Liepinsh, E.; Murray, A.J.; Lemieux, H.; Dambrova, M.; Tepp, K.; Puurand, M.; et al. "Altered mitochondrial metabolism in the insulin-resistant heart". Acta Physiologica 228 3 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077842678&partnerID=MN8TOARS.
    10.1111/apha.13430
  22. Almeida, N.; Carrara, G.; Palmeira, C.M.; Fernandes, A.S.; Parsons, M.; Smith, G.L.; Saraiva, N.. "Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism". Redox Biology 28 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074222003&partnerID=MN8TOARS.
    10.1016/j.redox.2019.101361
  23. Gomes, P.; Viana, S.D.; Nunes, S.; Rolo, A.P.; Palmeira, C.M.; Reis, F.. "The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders". Ageing Research Reviews 57 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85076952156&partnerID=MN8TOARS.
    10.1016/j.arr.2019.100983
  24. Martins, Rui Miguel; Teodoro, João Soeiro; Furtado, Emanuel; Rolo, Anabela Pinto; Palmeira, Carlos Marques; Tralhão, José Guilherme; Martins, R.M.; et al. "Evaluation of bioenergetic and mitochondrial function in liver transplantation". Clinical and Molecular Hepatology 25 2 (2019): 190-198. http://dx.doi.org/10.3350/cmh.2018.0087.
    10.3350/cmh.2018.0087
  25. Carmo, M.; Gonçalves, F.Q.; Canas, P.M.; Oses, J.-P.; Fernandes, F.D.; Duarte, F.V.; Palmeira, C.M.; et al. "Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A2A receptor over-activation in a rat model of Parkinson's disease". British Journal of Pharmacology 176 18 (2019): 3666-3680. http://www.scopus.com/inward/record.url?eid=2-s2.0-85070072977&partnerID=MN8TOARS.
    10.1111/bph.14771
  26. Alexandrino, H.; Palmeira, C.. "Correspondence". British Journal of Surgery 106 1 (2019): 152-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058912518&partnerID=MN8TOARS.
    10.1002/bjs.11055
  27. Palmeira, C.M.; Teodoro, J.S.; Amorim, J.A.; Steegborn, C.; Sinclair, D.A.; Rolo, A.P.. "Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins". Free Radical Biology and Medicine 141 (2019): 483-491. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069629808&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2019.07.017
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  98. Alves TC; Nunes PM; Palmeira CM; Jones JG; Carvalho RA. "Estimating gluconeogenesis by NMR isotopomer distribution analysis of [13C]bicarbonate and [1-13C]lactate.". (2008): http://europepmc.org/abstract/med/17683055.
    10.1002/nbm.1195
  99. La-Salete R; Oliveira MM; Palmeira CA; Almeida J; Peixoto FP. "Mitochondria a key role in microcystin-LR kidney intoxication.". (2008): http://europepmc.org/abstract/med/17461434.
    10.1002/jat.1251
  100. Peixoto, F.; Martins, F.; Amaral, C.; Gomes-Laranjo, J.; Almeida, J.; Palmeira, C.M.. "Evaluation of olive oil mill wastewater toxicity on the mitochondrial bioenergetics after treatment with Candida oleophila". Ecotoxicology and Environmental Safety 70 2 (2008): 266-275. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049108014&partnerID=MN8TOARS.
    10.1016/j.ecoenv.2007.11.003
  101. Palmeira CM; Rolo AP; Berthiaume J; Bjork JA; Wallace KB. "Hyperglycemia decreases mitochondrial function: the regulatory role of mitochondrial biogenesis.". (2007): http://europepmc.org/abstract/med/17761203.
    10.1016/j.taap.2007.07.015
  102. Rolo AP; Palmeira CM. "Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress.". (2006): http://europepmc.org/abstract/med/16490224.
    10.1016/j.taap.2006.01.003
  103. Teodoro J; Rolo AP; Oliveira PJ; Palmeira CM. "Decreased ANT content in Zucker fatty rats: relevance for altered hepatic mitochondrial bioenergetics in steatosis.". (2006): http://europepmc.org/abstract/med/16554051.
    10.1016/j.febslet.2006.02.078
  104. Ferreira FM; Moreno AJ; Seiça R; Santos MS; Palmeira CM. "Mitochondrial Bioenergetics, Diabetes, and Aging: Top-Down Analysis Using the Diabetic Goto-Kakizaki (GK) Rat as a Model.". (2006): http://europepmc.org/abstract/med/20021031.
    10.1080/15376520600616925
  105. Seiça R; Santos DL; Palmeira CM; Moreno AJ; Sena C; Cunha MF; Santos MS. "Mitochondrial function is not affected by renal morphological changes in diabetic goto-kakizaki rat.". (2005): http://europepmc.org/abstract/med/20021090.
    10.1080/15376520590968806
  106. Ferreira, M.; Coxito, P.M.; Sardão, V.A.; Palmeira, C.M.; Oliveira, P.J.; Ferreira M; Coxito PM; et al. "Bile acids are toxic for isolated cardiac mitochondria: A possible cause for hepatic-derived cardiomyopathies?". Cardiovascular Toxicology 5 1 (2005): 63-73. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544374442&partnerID=MN8TOARS.
    10.1385/CT:5:1:063
  107. Palmeira CM; Rolo AP. "Mitochondrially-mediated toxicity of bile acids.". (2004): http://europepmc.org/abstract/med/15363577.
    10.1016/j.tox.2004.06.001
  108. Oliveira PJ; Rolo AP; Sardão VA; Monteiro P; Gonçalves L; Providência LA; Palmeira CM; et al. "Advantages in the use of carvedilol versus propranolol for the protection of cardiac mitochondrial function.". Revista Portuguesa de Cardiologia 23 10 (2004): 1291-1298. http://europepmc.org/abstract/med/15641294.
  109. Rolo AP; Palmeira CM; Holy JM; Wallace KB. "Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis.". (2004): http://europepmc.org/abstract/med/14976352.
    10.1093/toxsci/kfh078
  110. Oliveira PJ; Seica R; Santos DL; Rolo AP; Sardao VA; Ferreira FM; Palmeira CM; Santos MS; Moreno AJ. "Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mitochondrial function in diabetic goto kakizaki rats.". (2004): http://europepmc.org/abstract/med/16120365.
    10.1016/j.mito.2004.02.005
  111. Oliveira PJ; Esteves T; Rolo AP; Palmeira CM; Moreno AJ. "Carvedilol inhibits the mitochondrial permeability transition by an antioxidant mechanism.". (2004): http://europepmc.org/abstract/med/15034201.
    10.1385/CT:4:1:11
  112. Oliveira PJ; Seiça R; Coxito PM; Rolo AP; Palmeira CM; Santos MS; Moreno AJ. "Enhanced permeability transition explains the reduced calcium uptake in cardiac mitochondria from streptozotocin-induced diabetic rats.". (2003): http://europepmc.org/abstract/med/14623121.
    10.1016/S0014-5793(03)01233-X
  113. Ferreira FM; Seiça R; Oliveira PJ; Coxito PM; Moreno AJ; Palmeira CM; Santos MS. "Diabetes induces metabolic adaptations in rat liver mitochondria: role of coenzyme Q and cardiolipin contents.". (2003): http://europepmc.org/abstract/med/14559118.
    10.1016/j.bbadis.2003.08.001
  114. Palmeira CM; Ferreira FM; Rolo AP; Oliveira PJ; Santos MS; Moreno AJ; Cipriano MA; Martins MI; Seiça R. "Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with alpha-naphthyl-isothiocyanate (ANIT).". (2003): http://europepmc.org/abstract/med/12927374.
    10.1016/S0300-483X(03)00163-X
  115. Rolo AP; Oliveira PJ; Moreno AJ; Palmeira CM. "Protection against post-ischemic mitochondrial injury in rat liver by silymarin or TUDC.". (2003): http://europepmc.org/abstract/med/12850694.
    10.1016/S1386-6346(03)00108-6
  116. Santos DL; Palmeira CM; Seiça R; Dias J; Mesquita J; Moreno AJ; Santos MS. "Diabetes and mitochondrial oxidative stress: a study using heart mitochondria from the diabetic Goto-Kakizaki rat.". (2003): http://europepmc.org/abstract/med/12841358.
    10.1023/A:1023475022025
  117. Ferreira FM; Oliveira PJ; Rolo AP; Santos MS; Moreno AJ; da Cunha MF; Seiça R; et al. "Cholestasis induced by chronic treatment with alpha-naphthyl-isothiocyanate (ANIT) affects rat renal mitochondrial bioenergetics.". Archives of Toxicology 77 4 (2003): 194-200. http://europepmc.org/abstract/med/12698234.
    10.1007/s00204-003-0441-3
  118. Rolo AP; Oliveira PJ; Moreno AJ; Palmeira CM. "Chenodeoxycholate induction of mitochondrial permeability transition pore is associated with increased membrane fluidity and cytochrome c release: protective role of carvedilol.". (2003): http://europepmc.org/abstract/med/16120330.
    10.1016/S1567-7249(03)00007-2
  119. Oliveira PJ; Rolo AP; Seiça R; Santos MS; Palmeira CM; Moreno AJ; Oliveira, P.J.; et al. "Cardiac mitochondrial calcium loading capacity is severely affected after chronic cholestasis in Wistar rats.". Journal of Investigative Medicine 51 2 (2003): 86-94. http://europepmc.org/abstract/med/12643513.
  120. Oliveira PJ; Esteves T; Rolo AP; Monteiro P; Gonçalves L; Palmeira CM; Moreno AJ. "Carvedilol: relation between antioxidant activity and inhibition of the mitochondrial permeability transition.". (2003): http://europepmc.org/abstract/med/12712810.
  121. Oliveira PJ; Rolo AP; Seiça R; Santos MS; Palmeira CM; Moreno AJ. "Reduction in cardiac mitochondrial calcium loading capacity is observable during alpha-naphthylisothiocyanate-induced acute cholestasis: a clue for hepatic-derived cardiomyopathies?". (2003): http://europepmc.org/abstract/med/12527405.
    10.1016/S0925-4439(02)00212-0
  122. Rolo AP; Palmeira CM; Wallace KB. "Mitochondrially mediated synergistic cell killing by bile acids.". (2003): http://europepmc.org/abstract/med/12527417.
    10.1016/S0925-4439(02)00224-7
  123. Oliveira PJ; Rolo AP; Seiça R; Santos MS; Palmeira CM; Moreno AJ. "Chronic cholestasis and cardiac mitochondrial function in Wistar rats: a model for cardiovascular alterations in chronic liver disease?". (2003): http://europepmc.org/abstract/med/12712811.
  124. Ferreira FM; Palmeira CM; Seiça R; Moreno AJ; Santos MS. "Diabetes and mitochondrial bioenergetics: alterations with age.". (2003): http://europepmc.org/abstract/med/12898645.
    10.1002/jbt.10081
  125. Oliveira, P.J.; Esteves, T.; Rolo, A.P.; Monteiro, P.; Gonçalves, L.; Palmeira, C.M.; Moreno, A.J.. "Carvedilol: Relation between antioxidant activity and inhibition of the mitochondrial permeability transition | Carvedilol: Relação entre a actividade antioxidante e inibição da transição de permeabilidade mitocondrial". Revista Portuguesa de Cardiologia 22 1 (2003): 55-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346034614&partnerID=MN8TOARS.
  126. Oliveira, P.J.; Rolo, A.P.; Seiça, R.; Santos, M.S.; Palmeira, C.M.; Moreno, A.J.. "Chronic cholestasis and cardiac mitochondrial function in wistar rats: A model for cardiovascular alterations in chronic liver disease? | Colestase crónica e funçá~o mitocondrial cardíaca em ratos wistar: Um modelo para alterações cardiovasculares no contexto de doenças hepáticas crónicas?". Revista Portuguesa de Cardiologia 22 1 (2003): 67-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344951202&partnerID=MN8TOARS.
  127. Oliveira PJ; Rolo AP; Monteiro P; Gonçalves L; Palmeira CM; Moreno AJ. "Impact of carvedilol on the mitochondrial damage induced by hypoxanthine and xantine oxidase--what role in myocardial ischemia and reperfusion?". (2002): http://europepmc.org/abstract/med/12621918.
  128. Rolo AP; Oliveira PJ; Seiça R; Santos MS; Moreno AJ; Palmeira CM. "Improved efficiency of hepatic mitochondrial function in rats with cholestasis induced by an acute dose of alpha-naphthylisothiocyanate.". (2002): http://europepmc.org/abstract/med/12127259.
    10.1006/taap.2002.9434
  129. Oliveira PJ; Rolo AP; Seiça R; Sardão V; Monteiro P; Gonçalves L; Providência L; et al. "Impact of diabetes on induction of the mitochondrial permeability transition.". Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 21 6 (2002): 759-766. http://europepmc.org/abstract/med/12194377.
  130. Rolo AP; Palmeira CM; Wallace KB. "Interactions of combined bile acids on hepatocyte viability: cytoprotection or synergism.". (2002): http://europepmc.org/abstract/med/11814708.
    10.1016/S0378-4274(01)00464-7
  131. Rolo, A.P.; Oliveira, P.J.; Seiça, R.; Santos, M.S.; Moreno, A.J.; Palmeira, C.M.; Rolo AP; et al. "Disruption of mitochondrial calcium homeostasis after chronic a-naphthylisothiocyanate administration: Relevance for cholestasis". Journal of Investigative Medicine 50 3 (2002): 193-200. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036092085&partnerID=MN8TOARS.
  132. Oliveira, P.J.; Rolo, A.P.; Monteiro, P.; Conçalves, L.; Palmeira, C.M.; Moreno, A.J.. "Impact of carvedilol on the mitochondrial damage induced by hypoxanthine and xantine oxidase - What role in myocardial ischemia and reperfusion? | Impacto do carvedilol sobre o dano mitocondrial induzido por hipoxantina/xantina oxidase - Que papel na isquemia e reperfusão do miocárdio?". Revista Portuguesa de Cardiologia 21 12 (2002): 1447-1455. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036998602&partnerID=MN8TOARS.
  133. Oliveira PJ; Rolo AP; Seiça R; Palmeira CM; Santos MS; Moreno AJ; Oliveira, P.J.; et al. "Decreased susceptibility of heart mitochondria from diabetic GK rats to mitochondrial permeability transition induced by calcium phosphate.". Bioscience Reports 21 1 (2001): 45-53. http://europepmc.org/abstract/med/11508693.
    10.1023/a:1010482017540
  134. Palmeira, C.M.; Santos, D.L.; Seiça, R.; Moreno, A.J.; Santos, M.S.; Palmeira CM; Santos DL; et al. "Enhanced mitochondrial testicular antioxidant capacity in Goto-Kakizaki diabetic rats: Role of coenzyme Q". American Journal of Physiology - Cell Physiology 281 3 50-3 (2001): http://www.scopus.com/inward/record.url?eid=2-s2.0-0034838234&partnerID=MN8TOARS.
  135. Oliveira, P.J.; Rolo, A.P.; Palmeira, C.M.; Moreno, A.J.M.. "Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase: Relevance to hypoxia/reoxygenation injury". Cardiovascular Toxicology 1 3 (2001): 205-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035750084&partnerID=MN8TOARS.
    10.1385/CT:1:3:205
  136. Rolo, A.P.; Oliveira, P.J.; Moreno, A.J.M.; Palmeira, C.M.. "Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria". Bioscience Reports 21 1 (2001): 73-80. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034899577&partnerID=MN8TOARS.
    10.1023/A:1010438202519
  137. Rolo, A.P.; Oliveira, P.J.; Moreno, A.J.M.; Palmeira, C.M.. "Protective effect of carvedilol on chenodeoxycholate induction of the permeability transition pore". Biochemical Pharmacology 61 11 (2001): 1449-1454. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035370544&partnerID=MN8TOARS.
    10.1016/S0006-2952(01)00620-7
  138. Santos, M.S.; Santos, D.L.; Palmeira, C.M.; Seiça, R.; Moreno, A.J.; Oliveira, C.R.. "Brain and liver mitochondria isolated from diabetic Goto-Kakizaki rats show different susceptibility to induced oxidative stress". Diabetes/Metabolism Research and Reviews 17 3 (2001): 223-230. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034944055&partnerID=MN8TOARS.
    10.1002/dmrr.200
  139. Zhou, S.; Palmeira, C.M.; Wallace, K.B.. "Doxorubicin-induced persistent oxidative stress to cardiac myocytes". Toxicology Letters 121 3 (2001): 151-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035912594&partnerID=MN8TOARS.
    10.1016/S0378-4274(01)00329-0
  140. Oliveira, P.J.; Rolo, A.P.; Sardão, V.A.; Coxito, P.M.; Palmeira, C.M.; Moreno, A.J.M.. "Carvedilol in heart mitochondria - Protonophore or opener of the mitochondrial KATP channels?". Life Sciences 69 2 (2001): 123-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035371154&partnerID=MN8TOARS.
    10.1016/S0024-3205(01)01109-2
  141. Oliveira, P.J.; Coxito, P.M.; Rolo, A.P.; Santos, D.L.; Palmeira, C.M.; Moreno, A.J.M.. "Inhibitory effect of carvedilol in the high-conductance state of the mitochondrial permeability transition pore". European Journal of Pharmacology 412 3 (2001): 231-237. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035793307&partnerID=MN8TOARS.
    10.1016/S0014-2999(01)00745-2
  142. Rolo AP; Oliveira PJ; Moreno AJ; Palmeira CM; Rolo, A.P.; Oliveira, P.J.; Moreno, A.J.M.; Palmeira, C.M.. "Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy.". Toxicological Sciences 57 1 (2000): 177-185. http://europepmc.org/abstract/med/10966524.
    10.1093/toxsci/57.1.177
  143. Rolo, A.P.; Palmeira, C.M.. "Cholestasis and mitochondrial dysfunction: A review". Toxic Substance Mechanisms 19 2 (2000): 83-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034458883&partnerID=MN8TOARS.
    10.1080/10769180052008878
  144. Palmeira, C.M.; Rana, M.I.; Frederick, C.B.; Wallace, K.B.. "Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids". Biochemical and Biophysical Research Communications 272 2 (2000): 431-435. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034616658&partnerID=MN8TOARS.
    10.1006/bbrc.2000.2797
  145. Ferreira FM; Seiça R; Santos MS; Palmeira CM; Ferreira, F.M.L.; Seiça, R.; Santos, M.S.; Palmeira, C.M.. "Age-related alterations in liver mitochondrial bioenergetics of diabetic Goto-Kakizaki rats.". Acta Diabetologica 36 4 (1999): 173-177. http://europepmc.org/abstract/med/10664324.
    10.1007/s005920050163
  146. Palmeira, C.M.. "Herbicide-induced mitochondrial and cellular liver toxicity: A review of paraquat, dinoseb, and 2,4-D effects". Toxic Substance Mechanisms 18 4 (1999): 187-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033457940&partnerID=MN8TOARS.
    10.1080/107691899229070
  147. Ferreira, F.M.L.; Palmeira, C.M.; Seiça, R.; Santos, M.S.. "Alterations of liver mitochondrial bioenergetics in diabetic Goto- Kakizaki rats". Metabolism: Clinical and Experimental 48 9 (1999): 1115-1119. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032857256&partnerID=MN8TOARS.
    10.1016/S0026-0495(99)90124-5
  148. Palmeira, C.M.; Ferreira, F.M.L.; Santos, D.L.; Ceiça, R.; Suzuki, K.-I.; Santos, M.S.. "Higher efficiency of the liver phosphorylative system in diabetic Goto-Kakizaki (GK) rats". FEBS Letters 458 2 (1999): 103-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032842698&partnerID=MN8TOARS.
    10.1016/S0014-5793(99)01144-8
  149. Serrano, J.; Palmeira, C.M.; Kuehl, D.W.; Wallace, K.B.. "Cardioselective and cumulative oxidation of mitochondrial DNA following subchronic doxorubicin administration". Biochimica et Biophysica Acta - Bioenergetics 1411 1 (1999): 201-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032961434&partnerID=MN8TOARS.
    10.1016/S0005-2728(99)00011-0
  150. Ferreira, F.M.L.; Palmeira, C.M.; Matos, M.J.; Seiç, R.; Santos, M.S.. "Decreased susceptibility to lipid peroxidation of Goto-Kakizaki rats: Relationship to mitochondrial antioxidant capacity". Life Sciences 65 10 (1999): 1013-1025. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033618489&partnerID=MN8TOARS.
    10.1016/S0024-3205(99)00332-X
  151. Custodio, J.B.A.; Palmeira, C.M.; Moreno, A.J.; Wallace, K.B.. "Acrylic acid induces the glutathione-independent mitochondrial permeability transition in vitro". Toxicological Sciences 43 1 (1998): 19-27. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031831694&partnerID=MN8TOARS.
    10.1006/toxs.1998.2448
  152. Moreno, A.J.M.; Santos, D.J.S.L.; Palmeira, C.M.; Moreno AJ; Santos DJ; Palmeira CM. "Ischemic heart disease: The role of mitochondria - Carvedilol prevents lipid peroxidation of mitochondrial membranes". Revista Portuguesa de Cardiologia 17 SUPPL. 2 (1998): 63-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031759966&partnerID=MN8TOARS.
  153. Palmeira, C.M.; Wallace, K.B.. "Benzoquinone inhibits the voltage-dependent induction of the mitochondrial permeability transition caused by redox-cycling naphthoquinones". Toxicology and Applied Pharmacology 143 2 (1997): 338-347. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030932708&partnerID=MN8TOARS.
    10.1006/taap.1996.8099
  154. Palmeira, C.M.; Madeira, V.M.C.. "Mercuric chloride toxicity in rat liver mitochondria and isolated hepatocytes". Environmental Toxicology and Pharmacology 3 3 (1997): 229-235. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030758726&partnerID=MN8TOARS.
    10.1016/S1382-6689(97)00018-5
  155. Palmeira, C.M.; Serrano, J.; Kuehl, D.W.; Wallace, K.B.. "Preferential oxidation of cardiac mitochondrial DNA following acute intoxication with doxorubicin". Biochimica et Biophysica Acta - Bioenergetics 1321 2 (1997): 101-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030880285&partnerID=MN8TOARS.
    10.1016/S0005-2728(97)00055-8
  156. Serrano, J.; Palmeira, C.M.; Wallace, K.B.; Kuehl, D.W.. "Determination of 8-hydroxydeoxyguanosine in biological tissue by liquid chromatography/electrospray ionization-mass spectrometry/mass spectrometry". Rapid Communications in Mass Spectrometry 10 14 (1996): 1789-1791. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030478989&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0231(199611)10:14<1789::AID-RCM752>3.0.CO;2-6
  157. Palmeira, C.M.; Moreno, A.J.M.; Madeira, V.M.C.; Wallace, K.B.. "Continuous monitoring of mitochondrial membrane potential in hepatocyte cell suspensions". Journal of Pharmacological and Toxicological Methods 35 1 (1996): 35-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029925338&partnerID=MN8TOARS.
    10.1016/1056-8719(95)00131-X
  158. Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C.. "Thiols metabolism is altered by the herbicides paraquat, dinoseb and 2,4-D: A study in isolated hepatocytes". Toxicology Letters 81 2-3 (1995): 115-123. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029590153&partnerID=MN8TOARS.
    10.1016/0378-4274(95)03414-5
  159. Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C.. "Mitochondrial bioenergetics is affected by the herbicide paraquat". Biochimica et Biophysica Acta - Bioenergetics 1229 2 (1995): 187-192. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028961733&partnerID=MN8TOARS.
    10.1016/0005-2728(94)00202-G
  160. Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C.. "Effects of paraquat, dinoseb and 2,4-D on intracellular calcium and on vasopressin-induced calcium mobilization in isolated hepatocytes". Archives of Toxicology 69 7 (1995): 460-466. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029054234&partnerID=MN8TOARS.
    10.1007/s002040050199
  161. Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C.. "Metabolic alterations in hepatocytes promoted by the herbicides paraquat, dinoseb and 2,4-D". Archives of Toxicology 68 1 (1994): 24-31. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028009773&partnerID=MN8TOARS.
    10.1007/s002040050025
  162. Palmeira, C.M.; Moreno, A.J.; Madeira, V.M.C.. "Interactions of herbicides 2,4-D and dinoseb with liver mitochondrial bioenergetics". Toxicology and Applied Pharmacology 127 1 (1994): 50-57. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028146853&partnerID=MN8TOARS.
    10.1006/taap.1994.1138
  163. Palmeira, C.M.; Santos, M.S.; Carvalho, A.P.; Oliveira, C.R.; Palmeira CM; Santos MS; Carvalho AP; Oliveira CR. "Membrane lipid peroxidation induces changes in ¿-[3H]aminobutyric acid transport and calcium uptake by synaptosomes". Brain Research 609 1-2 (1993): 117-123. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027309463&partnerID=MN8TOARS.
    10.1016/0006-8993(93)90863-I
  164. Palmeira, C.M.; Oliveira, C.R.. "Partitioning and membrane disordering effects of dopamine antagonists: Influence of lipid peroxidation, temperature, and drug concentration". Archives of Biochemistry and Biophysics 295 1 (1992): 161-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026729101&partnerID=MN8TOARS.
    10.1016/0003-9861(92)90502-N
Journal issue
  1. Palmeira, Carlos M.. "Metabolic Diseases: Drugs and Mitochondrial Targets". Current Medicinal Chemistry 22 20 (2015): http://www.eurekaselect.com/node/602/current-medicinal-chemistry/issue/22/1553/20/6495.
    Published • Editor
Thesis / Dissertation
  1. Palmeira, Carlos M.. "Alterações metabólicas em células hepáticas de rato induzidas por herbicidas de uso generalizado". PhD, Universidade de Coimbra, 1995. https://estudogeral.sib.uc.pt/handle/10316/2126?mode=full.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018 - Current PhD - Effects of drugs on epicardial tissue - impact on cardiac function
Co-supervisor
 Biociências (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - Current PhD - The physiology and health condition of urban dweller gulls in increasingly urbanized areas
Co-supervisor
 Biociências (PhD)
Universidade de Coimbra, Portugal
2018 - Current PhD - Predictive factors for non-anastomotic biliary strictures after liver ransplantation: prospective analysis of histological lesion and mitochondrial function of the bile duct in response to ischemia / re-perfusion. identification of new criteria for classification of marginality of the liver graft
Co-supervisor
 Ciências da Saúde (PhD)
Universidade de Coimbra, Portugal
2016 - 2019 PhD - Understanding the underlying mechanisms regulating aging and longevity
Co-supervisor
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra, Portugal
2015 - 2018 PhD - Liver transplantation: new prognostic factors of the regulation of mitochondrial function in ischemia/reperfusion
Co-supervisor
 Ciências da Saúde (PhD)
Universidade de Coimbra, Portugal
2014 - 2018 PhD - Energy for Liver Regeneration: Mitochondrial Bioenergetics and the Pathogenesis of Posthepatectomy Liver Dyfunction
Co-supervisor
 Ciências da Saúde (PhD)
Universidade de Coimbra, Portugal
2013 - 2016 PostDoc - Joao Soeiro Terra Teodoro (SFRH/BPD/94036/2013)
Co-supervisor
 SFRH/BPD/94036/2013 (Other)
2013 - 2016 PostDoc - Filipe Valente Duarte (SFRH/BPD/94898/2013)
Co-supervisor
 SFRH/BPD/94898/2013 (Other)
2013 - 2016 PostDoc - Ana Teresa Inácio Ferreira Varela (SFRH/BPD/94886/2013)
Co-supervisor
 SFRH/BPD/94886/2013 (Other)
2011 - 2014 PhD - The cardiotoxicity of mitoxantrone: a mechanistic approach using in vitro and in vivo models.
Co-supervisor
 Ciências Farmacêuticas (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2009 - 2013 PhD - Unravelling new roles for SIRT1 in mitochondrial biology
Co-supervisor
 Biologia (PhD)
Universidade de Coimbra, Portugal
2009 - 2012 PostDoc - Joana Luísa Lourenço Estevinho Pereira (SFRH/BPD/44733/2008)
Co-supervisor
 SFRH/BPD/44733/2008 (Other)
2009 - 2012 PhD - Physiologic pathways and molecular mechanisms regulating energy homeostasis in diabetes
Co-supervisor
 Biociências (PhD)
Universidade de Coimbra, Portugal
2009 - 2012 PhD - Regulation of mitochondrial function in ischemia/reperfusion: looking for therapeutic strategies in fatty livers
Co-supervisor
 Biologia (PhD)
Universidade de Coimbra, Portugal
2009 - 2012 PhD - Effects of exposition to dioxins and environmental pollutants: identification of biomarkers in chronic pulmonary diseases
Co-supervisor
 Biociências (PhD)
Universidade de Coimbra, Portugal
2008 - 2011 PhD - Impacto da diabetes e sua terapêutica na função cardiomiocitária na isquémia-reperfusão: estudo em modelos animais e em doentes com insuficiência cardíaca avançada
Co-supervisor
 Biologia (PhD)
Universidade de Coimbra, Portugal
2008 - 2011 PhD - The Effects of Environmental Conditions and Mercury on Common Estuarine Species. An Integrated Ecological and Toxicological Approach
Co-supervisor
 Biologia (PhD)
Universidade de Coimbra, Portugal
2007 - 2011 PhD - NMR studies on the regulation of glucose and fatty acid oxidation in liver, heart and skeletal muscle in awake rats
Co-supervisor
 Bioquímica (PhD)
Universidade de Coimbra, Portugal
2007 - 2011 PhD - Endoplasmic reticulum stress during amyloid ß peptide-induced cell death : role of mitochondria and glutamatergic N-methyl-D-aspartate receptors
Co-supervisor
 Biologia (PhD)
Universidade de Coimbra, Portugal
2007 - 2010 PostDoc - Pedro Emanuel Pato Martins (SFRH/BPD/35068/2007)
Co-supervisor
 SFRH/BPD/35068/2007 (Other)
2008 - 2009 PostDoc - João Gonçalo Leal de Oliveira e Silva Frade (SFRH/BPD/66253/2009)
Supervisor of João Gonçalo Leal de Oliveira e Silva Frade
SFRH/BPD/66253/2009 (Other)
Universidade de Coimbra, Portugal
2003 - 2009 PostDoc - Anabela Pinto Rolo (SFRH/BPD/14615/2003 and SFRH/BPD/26514/2006)
Supervisor of Anabela Pinto Rolo
 SFRH/BPD/14615/2003 and SFRH/BPD/26514/2006 (Other)
2002 - 2006 PhD - Avaliação do efeito de extractos de plantas a nível da bioenergética mitocondrial em ratos diabéticos
Co-supervisor
 Biologia (PhD)
Universidade de Coimbra, Portugal
2000 - 2003 PhD - Cholestasis and hepatic ischemia: bile acids therapy. Cellular mechanisms with relevance to mitochondrial function
Supervisor of Anabela Pinto Rolo
 Biologia (PhD)
Universidade de Coimbra, Portugal
2000 - 2003 PhD - Cardiac mitochondrial function:studies on the impact of disease conditions and on the protection afforded by carvedilol
Co-supervisor
 Biologia (PhD)
Universidade de Coimbra, Portugal

Association member

Society Organization name Role
2015 - Current Mitochondrial Physiology Society Membro
2000 - Current Sociedade Portuguesa de Bioquímica Membro
2000 - Current Society of Tozixology Membro

Committee member

Activity description
Role 		Institution / Organization
2015 - Current Membro do Comité Executivo da Mitochondrial Physiology Society (desde 2015)
Member
 Mitochondrial Physiology Society , Austria

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2016 - Current Perito A3ES
Evaluator
 A3ES, Portugal
2015 - 2015 Concurso de bolsas individuais de doutoramento e pós-doutoramento – 2015 (FCT) Painel de avaliação: Ciências do Ambiente (Co-coordenador)
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2014 - 2014 Concurso de bolsas individuais de doutoramento e pós-doutoramento – 2014 (FCT) Painel de avaliação: Ciências Ambientais e outras ciências naturais
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2013 - 2013 Concurso de bolsas individuais de doutoramento e pós-doutoramento – 2013 (FCT) Painel de avaliação: Biomedicina
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal