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Cristiano Manuel Colaço Ramos. Concluiu o Mestrado em Biologia Molecular e Genética em 2017/09/25 pela Faculdade de Ciências da Universidade de Lisboa e Licenciatura em Biologia em 2014/09/26 pela Faculdade de Ciências e Tecnologias da Universidade de Coimbra . Publicou 6 artigos em revistas especializadas. Domínio/Área Científica: Ciências Naturais e Ciências Biológicas; No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Cancro do colo do útero; Microambiente tumoral; Factor de crescimento epidérmico (EGF); Laminina y2 (LAMC2); Chemoresistance; Cysteine; Hypoxia; Metabolic selection; Ovarian cancer; Cystine/glutamate antiporter system Xc- (xCT); folate-targeted polyurea dendrimers; glutathione (GSH); hydrogen sulfide (H2S); platinum drugs; selenium chrysin (SeChry).
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Identification

Personal identification

Full name
Cristiano Manuel Colaço Ramos

Citation names

  • Ramos, Cristiano

Author identifiers

Ciência ID
9D13-ABE8-96CA
ORCID iD
0000-0002-3822-2835

Email addresses

  • cristiano.ramos@nms.unl.pt (Professional)
  • ramos.cristiano.93@gmail.com (Personal)

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Upper intermediate (B2) Advanced (C1)
Spanish; Castilian Intermediate (B1) Upper intermediate (B2) Elementary (A2) Advanced (C1)
Education
Degree Classification
2015/09 - 2017/09/25
Concluded
 Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Role of EGF mediated laminin gamma-2 chain in uterine cervix carcinoma" (THESIS/DISSERTATION)
 17
2011/09 - 2014/09/26
Concluded
 Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 15
2013/10 - 2014/09
Concluded
 Ciências Biológicas - Erasmus / Socrates program (Outros)
Universidade Federal de Uberlândia, Brazil
Affiliation

Science

Category
Host institution 		Employer
2019/09 - Current Research Trainee (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/07 - 2019/06 Research Trainee (Research) Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
(...)
2017/10 - 2018/06 Research Trainee (Research) Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
iNOVA4Health - Advancing Precision Medicine, Portugal
(...)
Projects

Contract

Designation Funders
2019/09 - Current New targets in diastolic heart failure: from comorbidities to personalized medicine - NETDIAMOND
03/SAICT/2015
Research Fellow
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07 - 2019/06 Targeting monocytes as angiogenesis promoters in cancer - New application for old drugs
UID/Multi/04462/2019
Research Fellow
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Fundação para a Ciência e a Tecnologia

iNOVA4Health
2017/10 - 2018/06 Ovarian cancer a suitable model to define metabolic profile as a tool to predict chemoresistance
PD/BD/105893/2014
Research Fellow
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
iNOVA4Health

Fundação para a Ciência e a Tecnologia
Concluded
2016/09 - 2017/09 Biomarkers and potential therapeutic targets in uterine cervix cancer
UIC 938-B
Master Student Fellow
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Terry Fox Foundation

Liga Portuguesa Contra o Cancro
2013/11 - 2014/09 Inhibition of Annexin A1 signaling to decrease breast cancer aggressiveness
CBB-APQ-0172612
CBB-APQ-03613-17
CNPq-465669/2014-0
Scientific Initiation Fellow
Universidade Federal de Uberlândia - Laboratório de Nanobiotecnologia, Brazil
 Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Conselho Nacional de Desenvolvimento Científico e Tecnológico
Concluded
Outputs

Publications

Conference poster
  1. Felix, A; Silva, F; Ramos, C; Lopes-Coelho, F; Nunes, S; Serpa, J. "Laminin332 (a3; ß3;¿2) genes and protein expression in cervical carcinomas". Paper presented in 25th Biennial Congress of the European Association for Cancer Research, 2018.
    10.1136/esmoopen-2018-eacr25.975
  2. Mota, P.; Ramos, C.; Serpa, J.; Bonifácio, Vasco D.B.. "Shedding light on ovarian cancer chemoresistance: The impact of BSO nanodelivery by polyurea dendrimers". Paper presented in Symposia on tumour biology: From basic biology to disease, 2018.
  3. Nunes, S.C.; Ramos, C.; Vicente, J.B.; Pereira, S.A.; Serpa, J.. "Enzymes involved in cysteine metabolism underlie hypoxia adaptation in ovarian cancer". Paper presented in 8th International Conference on Tumor Microenvironment, 2018.
  4. Ramos, C.; Vecchi, L.; Zóia, M.A.P.; Goulart, L.R.. "Role of Annexin A1 in EGFR signalling". Paper presented in I National Symposium on Biotechnological Applications, 2014.
  5. Zóia, M.A.P.; Vecchi, L.; Ramos, C.; Goulart, L.R.. "Annexin A1 Cleavage by Cathepsin D as New Approach for Signal Pathway Studies in MDA-MB-231 Metastatic Breast Cancer". Paper presented in I National Symposium on Biotechnological Applications, 2014.
  6. Ramos, C.; Vecchi, L.; Zóia, M.A.P.; Matias, B.F.; Goulart, L.R.. "Annexin A1 signaling through FPR1 receptor downregulates IL-6 expression in triple negative breast cancer cell line". Paper presented in 60th Brazilian Congress of Genetics, 2014.
  7. Zóia, M.A.P.; Vecchi, L.; Ramos, C.; Goulart, L.R.. "Initial approach of Annexin A1 as possible therapeutic target in triple negative breast cancer". Paper presented in 60th Brazilian Congress of Genetics, 2014.
Journal article
  1. Marques, André R. A.; Ramos, Cristiano; Machado-Oliveira, Gisela; Vieira, Otília V.. "Lysosome (Dys)function in Atherosclerosis—A Big Weight on the Shoulders of a Small Organelle". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.658995.
    Open access • Published • 10.3389/fcell.2021.658995
  2. Machado-Oliveira, Gisela; Ramos, Cristiano; Marques, André R. A.; Vieira, Otília V.. "Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis". Cells 9 10 (2020): 2146. http://dx.doi.org/10.3390/cells9102146.
    Published • 10.3390/cells9102146
  3. Cruz; Mota; Ramos; Pires; Mendes; Silva; Nunes; Bonifácio; Serpa. "Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance". Antioxidants 9 2 (2020): 133. http://dx.doi.org/10.3390/antiox9020133.
    10.3390/antiox9020133
  4. Inês Santos; Cristiano Ramos; Cindy Mendes; Catarina O. Sequeira; Catarina S. Tomé; Dalila G.H. Fernandes; Pedro Mota; et al. "Targeting Glutathione and Cystathionine ß-Synthase in Ovarian Cancer Treatment by Selenium–Chrysin Polyurea Dendrimer Nanoformulation". Nutrients 11 10 (2019): 2523-2523. https://doi.org/10.3390/nu11102523.
    10.3390/nu11102523
  5. Mendes, Cindy; Lopes-Coelho, Filipa; Ramos, Cristiano; Martins, Filipa; Santos, Inês; Rodrigues, Armanda; Silva, Fernanda; et al. "Unraveling FATP1, regulated by ER-ß, as a targeted breast cancer innovative therapy". (2019): http://www.scopus.com/inward/record.url?scp=85072847618&partnerID=8YFLogxK.
    https://doi.org/10.1038/s41598-019-50531-3
  6. Vecchi, Lara; Alves Pereira Zóia, Mariana; Goss Santos, Tiago; de Oliveira Beserra, Adriano; Colaço Ramos, Cristiano Manuel; França Matias Colombo, Bruna; Paiva Maia, Yara Cristina; et al. "Inhibition of the AnxA1/FPR1 autocrine axis reduces MDA-MB-231 breast cancer cell growth and aggressiveness in vitro and in vivo". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865 9 (2018): 1368-1382. http://dx.doi.org/10.1016/j.bbamcr.2018.06.010.
    Open access • Published • 10.1016/j.bbamcr.2018.06.010
  7. Nunes, Sofia C.; Lopes-Coelho, Filipa; Gouveia-Fernandes, Sofia; Ramos, Cristiano; Pereira, Sofia A.; Serpa, Jacinta; Centro de Estudos de Doenças Crónicas (CEDOC). "Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer". (2018): http://www.scopus.com/inward/record.url?scp=85049032652&partnerID=8YFLogxK.
    https://doi.org/10.1186/s12862-018-1214-1
  8. Nunes, Sofia C.; Ramos, Cristiano; Lopes-Coelho, Filipa; Sequeira, Catarina O; Silva, Fernanda; Gouveia-Fernandes, Sofia; Rodrigues, Armanda; et al. "Cysteine allows ovarian cancer cells to adapt to hypoxia and to escape from carboplatin cytotoxicity". (2018): http://hdl.handle.net/10362/41058.
    https://doi.org/10.1038/s41598-018-27753-y
Thesis / Dissertation
  1. Ramos, Cristiano Manuel Colaço. "Role of EGF mediated laminin y2 chain in uterine cervix carcinoma". Master, 2017. http://hdl.handle.net/10451/30719.
Activities

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2017/04/28 - Current I Advancing Precision Medicine (iNOVA4Health) - Immunology and Cancer
Conference
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
2020/02 - 2020/02 Cytometry Data Analysis in FlowJo v10 – Seminar and training - Advanced tools and plugins
Workshop
Instituto Gulbenkian de Ciência, Portugal
2019/09 - 2019/09 LYSOCIL - Workshop Lysosome Biology
Conference
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019/05/22 - 2019/05/24 Clinical Trials Course: from Theory to Practice
Symposium
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
2019 - 2019 ICH Good Clinical Practice E6 (R2) Course
Global Health Training Centre, Portugal
2018/10/18 - 2018/10/19 2nd NOVA Medical School Symposium – Chronic Diseases and Translational Science
Conference
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/06/08 - 2018/06/08 Short Course on Lab Animal Pathology
Workshop
Instituto de Medicina Molecular, Portugal
2017 - 2017 Scientific Writing vs Science Writing: from the Data to the Narrative
Workshop
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 III Bioengineering week
Meeting
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2016 - 2016 I NEBFUL’s BioSAM – Biological Sciences Annual Meeting
Meeting
Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2016 Cancer Cell Migration in Space and Time
Conference
Research Tumor Biology (ReTuBi), Portugal
2014 - 2014 I Workshop on Applied Physiology
Workshop
Universidade Federal de Uberlândia, Brazil
2014 - 2014 I International Congress of Basic Health Sciences
Congress
Universidade Federal de Uberlândia, Brazil
2014 - 2014 I Interdisciplinary Scientific Forum on Diabetes Mellitus
Conference
Universidade Federal de Uberlândia, Brazil
2014 - 2014 60th Brazilian Congress of Genetics
Congress
Sociedade Brasileira de Genética, Brazil
2014 - 2014 Workshop on Oral Communication
Workshop
Universidade Federal de Uberlândia, Brazil
2014 - 2014 IV Regional Meeting of Biomedicine
Meeting
Universidade Federal de Uberlândia, Brazil
2013 - 2013 XXIV Scientific Week of Biological Studies
Meeting
Universidade Federal de Uberlândia, Brazil
2012 - 2012 XV National Meeting of Biology Students
Meeting
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012 - 2012 VI Annual Scientific Congress, “Immunology, Immunological Diseases and Immunotherapies”
Congress
Universidade de Coimbra Faculdade de Farmácia, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/05/29 - 2019/05/31 Practical sessions - Molecular and Cellular alterations in Cancer NOVA Biomedical Research (NBR) (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/05/30 - 2018/06/01 Practical sessions - Molecular and Cellular alterations in Cancer NOVA Biomedical Research (NBR) (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/04/12 - 2018/04/13 Practical sessions - Carcinogenesis Integrated Master Degree in Medicine (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Mentoring / Tutoring

Topic Student name
2018/09 - 2019/06 Cysteine Metabolism and Pancreatic Neuroendocrine Tumours (PNETs) Chemoresistance Rakhi Chanda Roy
2018/09 - 2019/02 xCT (SLC7A11) - Antiporter system role in ovarian cancer chemoresistance Donato Urso
Distinctions

Award

2014 1st place – Poster presentation, Scientific initiation in Human Genetic field, Brazilian Genetics Society
Sociedade Brasileira de Genética, Brazil
2014 Honour Mention - 2nd place, at Nacional Symposium of Biotechnology Applications

Other distinction

2013 Scholarship Santander Totta/UC
Banco Santander Totta, Portugal

Universidade de Coimbra, Portugal