???global.info.a_carregar???
Identification

Personal identification

Full name
José Miguel Antunes Codêsso

Citation names

  • Codêsso, José Miguel

Author identifiers

Ciência ID
9D1C-5F50-904E

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2020 - 2024
Ongoing
 Biomedical Sciences [PhD] (Doutoramento)
University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal
"Unraveling the role of RNA-binding proteins in Polyglutamine Diseases: from pathogenesis to therapeutics" (THESIS/DISSERTATION)
2012 - 2015
Concluded
 Biochemistry [MSc] (Mestrado)
University of Coimbra, Faculty of Sciences and Technology, Department of Life Sciences, Portugal
"Evaluation of the safety of a therapeutic strategy for Machado-Joseph Disease - Silencing human mutant ataxin-3 using a target-specific shRNA encoded by a directly brain-delivered lentiviral vector" (THESIS/DISSERTATION)
 17
2014
Concluded
 Laboratory Animal Sciences (FELASA Category B) (Diploma de especialização)
Portuguese Society of Laboratory Animal Sciences , Portugal

University of Coimbra, Center for Neuroscience and Cell Biology, Portugal
Approved / Accredited
2007 - 2012
Concluded
 Biochemistry [BSc] (Licenciatura)
University of Coimbra, Faculty of Sciences and Technology, Department of Life Sciences, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
2020 - Current Researcher (Research) University of Algarve, Center for Biomedical Research, Molecular Neuroscience and Gene Therapy Laboratory, Portugal
2020 - Current Researcher (Research) University of Coimbra, Center for Neuroscience and Cell Biology, Vectors and Gene Therapy Group, Molecular Therapy of Brain Disorders Laboratory, Portugal
2015 - 2018 Research Trainee (Research) University of Coimbra, Center for Neuroscience and Cell Biology, Vectors and Gene Therapy Group, Molecular Therapy of Brain Disorders Laboratory, Portugal
Projects

Grant

Designation Funders
2020 - Current Overexpression of the RNA-binding protein X as a therapeutic strategy to Machado-Joseph disease and other Polyglutamine diseases
#22424
PhD Student Fellow
University of Algarve, Center for Biomedical Research, Molecular Neuroscience and Gene Therapy Laboratory, Portugal
 The French Muscular Dystrophy Association
2020 - Current Unraveling the role of RNA-binding proteins in Polyglutamine Diseases: from pathogenesis to therapeutics
SFRH/BD/148760/2019
PhD Student Fellow
University of Algarve, Center for Biomedical Research, Molecular Neuroscience and Gene Therapy Laboratory, Portugal

University of Coimbra, Center for Neuroscience and Cell Biology, Vectors and Gene Therapy Group, Molecular Therapy of Brain Disorders Laboratory, Portugal
Foundation for Science and Technology
Outputs

Publications

Book chapter
  1. Codêsso, José Miguel; A. Matos, Carlos; Nóbrega, Clévio. "RNA Interference Applications for Machado-Joseph Disease". In RNA Therapeutics - History, Design, Manufacturing, and Applications. IntechOpen, 2023.
    10.5772/intechopen.109261
Conference abstract
  1. Conceição, André; Koppenol, Rebekah; Silva, Joana; Marcelo, Adriana; Afonso, Inês T.; Afonso-Reis, Ricardo; Codêsso, José Miguel; et al. "An RNA-binding protein alleviates pathology in two different mouse models of polyglutamine diseases". Paper presented in 24th Annual Meeting of the Portuguese Society for Human Genetics, Lisbon, 2021.
    Published
Conference poster
  1. Moreira-Gomes, Tiago; Brito, David V.C.; Afonso-Reis, Ricardo; Codêsso, José Miguel; Voigt, Aaron; Nóbrega, Clévio David Rodrigues. "Translational regulation: exploring the impact of TRMT2A in Spinocerebellar ataxia type 3 /Machado-Joseph Disease". Paper presented in 9th European Neuroscience Conference by Doctoral Students (ENCODS), 2023.
  2. Moreira-Gomes, Tiago; Brito, David V.C.; Afonso-Reis, Ricardo; Codêsso, José Miguel; Voigt, Aaron; Nóbrega, Clévio David Rodrigues. "Silencing Trmt2a as a novel therapeutic target in Spinocerebellar ataxia type 3 /Machado-Joseph Disease". Paper presented in Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023), 2023.
  3. Couto, Filipa Lopes; Codêsso, José Miguel; Paulino, Rodrigo; Nóbrega, Clévio David Rodrigues. "Modulation of the RNA binding protein HSPA8 in Spinocerebellar Ataxia type 2". Paper presented in Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023), 2023.
  4. Couto, Filipa Lopes; Codêsso, José Miguel; Paulino, Rodrigo; Nóbrega, Clévio David Rodrigues. "Overexpression of the RNA binding protein HSPA8 in Spinocerebellar Ataxia type 2". Paper presented in 9th European Neuroscience Conference by Doctoral Students (ENCODS), 2023.
  5. Codêsso, José Miguel; Brito, David V.C.; Mendonça, Liliana; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "Unraveling the role of the RBP HSPA8 in Spinocerebellar Ataxia type 3: from pathogenesis to therapeutics". Paper presented in Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023), 2023.
  6. Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "A expressão da proteína G3BP1 reduz as anomalias neuropatológicas e motoras em modelos da ataxia espinocerebelosa tipo 3". Paper presented in Portuguese Society of Movement Diseases Meeting 2022, 2022.
  7. Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "RBP-X protein mitigates disease-associated pathology in different polyglutamine diseases". Paper presented in 1st Virtual Conference at European Society for Neurochemestry, 2021.
  8. Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "RBP-X protein mitigates motor deficits in differents mice models of polyglutamine diseases". Paper presented in 51st Annual Meeting of the Portuguese Society of Pharmacology, 2021.
  9. Koppenol, Rebekah; Conceição, André; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "G3BP1 expression mitigates pathological phenotype in mouse models different polyglutamine diseases". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  10. Afonso-Reis, Ricardo; Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "Assessing the Role of Different G3BP1 Regions in the Mitigation of the Pathological Phenotype in SCA2 and SCA3 Disease Models". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  11. Koppenol, Rebekah; Conceição, André; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "G3BP1 as a therapeutic target for spinocerebellar ataxias: mitigation of pathological traits in different mouse models". Paper presented in IV Jornadas Algarve Biomedical Center, 2021.
  12. Afonso-Reis, Ricardo; Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "Mapping the domains of RBP-X towards mitigation of the pathological phenotype in polyglutamine disease models". Paper presented in IV Jornadas Algarve Biomedical Center, 2021.
  13. Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "An RNA-binding protein alleviates pathology in two different mouse models of polyglutamine diseases". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics, 2020.
Journal article
  1. Koppenol, Rebekah; Conceição, André; Afonso, Inês T; Afonso-Reis, Ricardo; Costa, Rafael G; Tomé, Sandra; Teixeira, Diogo; et al. "The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits". Brain (2022): http://dx.doi.org/10.1093/brain/awac473.
    Open access • 10.1093/brain/awac473
  2. Vasconcelos-Ferreira, Ana; Carmo-Silva, Sara; Codêsso, José Miguel; Silva, Patrick; Martinez, Alberto Rolim Muro; França Jr, Marcondes Cavalcante; Nóbrega, Clévio; Pereira de Almeida, Luís. "The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado-Joseph disease". Neuropathology and Applied Neurobiology (2021): http://dx.doi.org/10.1111/nan.12763.
    10.1111/nan.12763
  3. Nóbrega, Clévio David Rodrigues*; Codêsso, José Miguel*; Mendonça, Liliana*; Pereira de Almeida, Luís. "RNA Interference Therapy for Machado–Joseph Disease: Long-Term Safety Profile of Lentiviral Vectors Encoding Short Hairpin RNAs Targeting Mutant Ataxin-3". Human Gene Therapy 30 7 (2019): 841-854. http://dx.doi.org/10.1089/hum.2018.157.
    10.1089/hum.2018.157
Thesis / Dissertation
  1. Codêsso, José. "Evaluation of the safety of a therapeutic strategy for Machado-Joseph Disease - Silencing human mutant ataxin-3 using a target-specific shRNA encoded by a directly brain-delivered lentiviral vector". Master, 2015.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023 Targeting transcriptional dysregulation in Machado-Joseph disease: silencing Trmt2a as a novel therapeutic target 4th International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Challenges from Research to Clinics
(Covilhã, Portugal)
2023 Overexpression of the RNA binding protein HSPA8 in Spinocerebellar Ataxia type 2 9th European Neuroscience Conference by Doctoral Students (ENCODS)
(Faro, Portugal)
2021 RBP-X protein mitigates disease traits in different mice models of polyglutamine diseases 51st Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2021 Mapping the domains of RBP-X towards mitigation of the pathological phenotype in polyglutamine disease models 51st Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2021 G3BP1 as a therapeutic target for spinocerebellar ataxias: mitigation of pathological traits in different mouse models IV Jornadas Algarve Biomedical Center
(Moura, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021 - 2021 RBP Modulation as a Therapeutic Strategy for Spinocerebellar Ataxia Type 3
Co-supervisor of Maria de Mendonça Sabbo
 Biomedical Sciences (Scientific initiation)
University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023 - 2023 Volunteer work at Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023) (2023)
Conference
 Algarve Biomedical Center - Research Institute, Portugal

University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023 - 2023 Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023)
Conference
Algarve Biomedical Center - Research Institute, Portugal

University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal
2022 - 2022 ABC-RI International Forum (Spring Edition 2022) - Gene and Cell Therapies for Healthy Ageing
Meeting
Algarve Biomedical Center - Research Institute, Portugal
2021 - 2021 Course 'Models of the Blood-Brain Barrier - Scientific Tools to Target the Brain'
Other
University of Lisbon, Faculty of Pharmacy, Portugal
2021 - 2021 Course 'Optical Microscopy Imaging for Biosciences'
Other
University of Porto, Institute for Research and Innovation in Health, Portugal
2021 - 2021 Advanced Therapies 2021
Congress
Terrapinn Holdings Ltd, United Kingdom
2021 - 2021 The CRISPR Revolution - a workshop on gene editing, from cells to animal models
Workshop
University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal
2021 - 2021 CRISPR 2021
Conference
Institut Pasteur, France
2021 - 2021 ABC-RI International Forum (Fall Edition 2021) - Neuroscience in Health and Disease
Meeting
Algarve Biomedical Center - Research Institute, Portugal
2021 - 2021 Course 'Stem Cell Technologies'
Other
University of Lisbon, Faculty of Pharmacy, Portugal

Champalimaud Foundation, Portugal
2021 - 2021 Annual mRNA Day 21
Meeting
TriLink BioTechnologies Inc, United States

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022 - 2022 Gene and Cell Therapy (seminars) - Cytotoxicity of RNA interference-mediated gene silencing Biomedical Sciences (Licenciatura) University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal
2020 - 2022 Gene and Cell Therapy (practical classes) - Activating Autophagy as a Therapeutic Strategy for Huntington's Disease in a Cellular Model (assistant teacher) Biomedical Sciences (Licenciatura) University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal
2021 - 2021 Animal Models in Biomedical Research (practical session & bioterium (animal facility) visit) - Methods for Animal Behavior Research Biomedical Sciences (Licenciatura) University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal

Mentoring / Tutoring

Topic Student name
2022 - 2023 Modulation of an RBP as Potential Therapeutic Strategy for Spinocerebellar Ataxia Type 2 - Thesis / Dissertation [Biomedical Sciences (Master)] - University of Algarve, Faculty of Medicine and Biomedical Sciences Filipa Lopes Couto
2022 - 2022 Mouse Behaviour Experiments for the Evaluation of a Potential Theraphy for SCA3 - Optional Laboratorial Internships [Biomedical Sciences (Master)] - University of Algarve, Faculty of Medicine and Biomedical Sciences Maria de Mendonça Sabbo
Distinctions

Other distinction

2019 PhD fellowship, FCT reference: SFRH/BD/148760/2019