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Sandra Maria Araújo da Costa. She completed her PhD in Health Sciences Doctoral degree in knowledge area of Biological and Biomedical Sciences in 2007 from the University of Minho School of Medicine, a Master's degree in Oncology in 2003 from the University of Porto Abel Salazar Institute of Biomedical Sciences and a degree in Applied Biology in 2000 from the University of Minho School of Sciences. She is a Collaborating Scientist at the University of Minho, Institute for Research in Life Sciences and Health. He has published 54 articles in specialized journals. He has received six awards and/or honors. In her professional activities, he has interacted with 208 collaborators in co-authoring scientific papers.
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Identification

Personal identification

Full name
SANDRA MARIA ARAÚJO DA COSTA

Citation names

  • Costa, Sandra

Author identifiers

Ciência ID
9E12-3C08-9506
ORCID iD
0000-0001-6795-4245

Websites

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2003/01/01 - 2007/10/23
Concluded
 Health Sciences Doctoral degree, knowledge area of Biological and Biomedical Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
"DNA repair genetic polymorphisms and breast cancer in a Portuguese population" (THESIS/DISSERTATION)
 Approved unanimously
2000/10 - 2003/07
Concluded
 Master in Oncology (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"NAT2 Genetic polymorphisms and susceptibility to solid tumors " (THESIS/DISSERTATION)
 Very good
1996/10 - 2000/09/06
Concluded
 Biologia Aplicada (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Genetic polymorphisms in NAT2 and susceptibility to breast cancer" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2013/06/30 - 2022/07/25 Auxiliary Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007/11/01 - 2013/06/29 Postdoc (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009/09/15 - 2010/10/31 Postdoc (Research) Vlaams Instituut voor Biotechnologie KU Leuven Center for Cancer Biology, Belgium
2000/10/01 - 2002/12/31 Researcher (Research) Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2008/12/01 - 2009/07/31 Invited Assistant Professor (University Teacher) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2002/10/01 - 2003/09/30 Invited Assistant (Polytechnic Teacher) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Others

Category
Host institution 		Employer
2017/11 - 2020/03 Coordinator of International Programme of Advanced Courses Universidade do Minho Escola de Medicina, Portugal
2000/02/01 - 2000/09/30 Trainee Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Projects

Grant

Designation Funders
2016/07 - 2018/08 Unlocking the role of extracellular vesicles in the modulation of macrophage-driven lung differentiation and repair
ICVS/3B's Associate Laboratory Grant 2016
Principal investigator
Laboratório Associado ICVS 3B's, Portugal
 Laboratório Associado ICVS 3B's
Concluded
2003 - 2005 DNA repair genetic polymorphisms and breast cancer in Portuguese and Brazilian populations
DNA repair genetic polymorphisms and breast cancer in Portuguese and Brazilian populations
Other
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação Luso-Americana
Concluded

Contract

Designation Funders
2021/01/01 - Current LA ICVS-3Bs (2019) – Associate Laboratory, Life and Health Sciences Research Institute/Biomaterials, Biodegradables and Biomimetics Research Group (LA ICVS/3B's)
UIDB/50026/2020-FCT/COMPETE 2020
Researcher
Laboratório Associado ICVS 3B's, Portugal

Universidade do Minho Escola de Medicina, Portugal
Ongoing
2023/01/02 - 2026/01/01 Metabolic Control of Immune Cell Function in Respiratory Fungal Disease
2022.06674.PTDC
10.54499/2022.06674.PTDC
Invited Scientist Fellow
Universidade do Minho, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 ICVS/3B¿s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos
LA/P/0050/2020
10.54499/LA/P/0050/2020
UID/Multi/50026/2019
Researcher
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07 - 2022/07 Macrophage-secreted mediators as therapeutic strategy for preterm lung maturation
POCI-01-0145-FEDER-028113
Principal investigator
FEDER, through the Competitiveness Internationalization Operational Programme (POCI), and by National funds, through the Foundation for Science and Technology (FCT)
Ongoing
2018/07 - 2021/08 Innate regulation of inflammation in sarcoidosis
PTDC/MED-GEN/28778/2017
Researcher
Laboratório Associado ICVS 3B's, Portugal

Universidade do Minho Escola de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/07 - 2021/08 Microbiota in cancer immunosurveillance: new avenues for immunotherapy
PTDC/MED-ONC/28658/2017
Researcher
Laboratório Associado ICVS 3B's, Portugal

Universidade do Minho Escola de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/01/01 - 2020/12/31 EXOLUNG: Umbilical Cord Blood derived exosomes for treatment of COVID-19 related Acute Respiratory Distress Syndrome (ARDS)
CENTRO-01-02B7-FEDER-070018
Scientific consultant
Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluded
2015/06 - 2020/06 Unravelling the key roles of tissue macrophages in lung morphogenesis and injury
IF/00959/2014
Principal investigator
Ministério da Ciência Tecnologia e Ensino Superior
Ongoing
2013/06/01 - 2015/06/28 Integration of cutting-edge health science research and ground-breaking technologies for the development of new clinically useful therapies, tissue regeneration strategies, advanced prophylactic measures and diagnosis methods
NORTE-01-0124-FEDER-000016
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Programa Operacional Regional do Norte (ON.2)
Concluded
2010 - 2011 Induction of endothelial phalanx cells for therapeutic angiogenesis
G.0726.10N
Post-doc
Vlaams Instituut voor Biotechnologie KU Leuven Center for Cancer Biology, Belgium
 Fonds Wetenschappelijk Onderzoek Vlaanderen
Concluded
Outputs

Publications

Conference abstract
  1. Fernandes, R; Barbosa-Matos, C; Borges-Pereira, C; Costa, S. "Glycogen synthase kinase-3 inhibition by CHIR99021 promotes alveolar epithelial cell proliferation and lung regeneration in acute lung injury". Paper presented in Repair and regeneration in chronic lung disease and lung cancer, 19th ERS Lung Science Conference, 2021.
    Published • 10.1183/23120541.lsc-2021.88
  2. Barbosa-Matos, Catarina; Borges-Pereira, Caroline; Libório-Ramos, Sofia; Mazzone, Massimiliano; Costa, Sandra. "c-Met expression induction in immune cells modulates pulmonary fibrosis progression". Paper presented in ERS International Congress, Virtual Meeting, 2020.
    Published • 10.1183/13993003.congress-2020.2583
  3. Costa, Sandra. "Tissue macrophages modulate alveolar epithelial and myofibroblast differentiation during fetal lung sacculation". Paper presented in ASCB/EMBO 2017 Meeting, Philadelphia, 2017.
    Published • 10.1091/mbc.e17-10-0618
Conference poster
  1. Oliveira, Marcela; Caroline Borges-Pereira; Azeredo-Rodrigues, Catarina; Catarina Barbosa-Matos; Costa, Sandra. Corresponding author: Costa, Sandra. "Fetal lung macrophage-derived secretome modulates the saccular stage of lung development". Paper presented in Portuguese Society of Immunology - XLVII Anual Meeting ¿At the crossroads of human immunology¿, 2022.
  2. Oliveira, Marcela; Caroline Borges-Pereira; Costa, Sandra. Corresponding author: Costa, Sandra. "A novel technical approach for ex vivo sacculogenesis lung studies - Three-Dimensional Fetal Precision-Cut Lung Slices". Paper presented in European Research Society Research Seminar ¿Innovative 3D models for understanding mechanisms underlying lung diseases: powerful tools for translational research", 2022.
  3. Pereira-Nunes, Andreia; Santos, Nuno; Costa, Sandra; Baltazar, Fátima; Granja, Sara. "Lactate transporters as targets to improve immunotherapy". Paper presented in EACR-AACR-ASPIC 2020 Conference: Tumor Microenvironment, 2020.
  4. Libório-Ramos, Sofia; Costa, Sandra. "Pulmonary macrophages profile during the inflammatory phase of lung fibrosis.". Paper presented in Champalimaud Research Symposium “Tissue Environment in Health and Disease”., 2019.
  5. Barbosa-Matos, Catarina; Costa, Sandra. "Induction of c-Met expression in immune cells drives pulmonary fibrosis". Paper presented in Champalimaud Research Symposium “Tissue Environment in Health and Disease", 2019.
  6. Barbosa-Matos, Catarina; Costa, Sandra. "c-Met deletion attenuates lung fibrosis by modulation of immune cells recruitment.". Paper presented in XLIV Annual Meeting of the Portuguese Society of Immunology, 2018.
    10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6051
  7. Campos, Cláudia F.; Costa, Sandra; Carvalho, Agostinho. "The soluble pattern recognition receptor ptx3 regulates granuloma formation in sarcoidosis.". Paper presented in XLIV Annual Meeting of the Portuguese Society of Immunology., 2018.
  8. Granja, Sara; Costa, Sandra; Baltazar F. "Cancer cell-macrophage metabolic symbiosis: unravelling the role of monocarboxylate transporters (MCTs)". Paper presented in FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2017.
  9. Borges-Pereira, Caroline; Costa, Sandra. "Fetal lung tissue macrophages deficiency modulates apoptosis and alveolar epithelial differentiation during early stages of alveologenesis". Paper presented in XLIII Annual Meeting of the Portuguese Society of Immunology, 2017.
  10. Barbosa, Ana Margarida; Costa, Sandra; Torrado, Egídio. "Dietary zinc supplementation promotes tumor overgrowth through a microbiota-tumor axis". Paper presented in XLIII Annual Meeting of the Portuguese Society of Immunology, 2017.
  11. Barbosa, Ana Margarida; Costa, Sandra; Torrado, Egídio. "IL-10 modulates tumor immune surveillance via myeloid-derived suppressor cells.". Paper presented in XLII Annual Meeting of the Portuguese Society of Immunology, 2016.
    10.1158/1557-3265.aacrahns17-ia22
  12. Barbosa, Ana Margarida; Costa, Sandra; Torrado, Egídio. "A role for IL-10 in modulating tumor immune surveillance". Paper presented in XLI Annual Meeting of the Portuguese Society of Immunology, 2015.
  13. Pojo, Marta; Gonçalves, Céline S.; Xavier-Magalhães, Ana; Oliveira, Ana I.; Gonçalves, Tiago; Rodrigues, Ana J.; Costa, Sandra; et al. "A Transcriptomic Signature Mediated by HOXA9 Sustains Human Glioblastoma Aggressiveness, Resistance to Chemotherapy and Glioma Initiation". Paper presented in VI National Meeting of the Portuguese Association of Neuro-Oncology, 2013.
  14. Pojo, Marta; Gonçalves, Céline S.; Xavier-Magalhães, Ana; Fernandes, Ricardo; Gonçalves, Tiago; Rodrigues, Ana J.; Costa, Sandra; et al. "HOXA9 Promotes Glioma Initiation and Sustains Human Glioblastoma Aggressiveness and Resistance to Therapy". Paper presented in XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting, 2013.
Journal article
  1. Fernandes, Raquel; Barbosa-Matos, Catarina; Borges-Pereira, Caroline; Carvalho, Ana Luísa Rodrigues Toste de; Costa, Sandra. "Glycogen Synthase Kinase-3 Inhibition by CHIR99021 Promotes Alveolar Epithelial Cell Proliferation and Lung Regeneration in the Lipopolysaccharide-Induced Acute Lung Injury Mouse Model". International Journal of Molecular Sciences 25 2 (2024): 1279. http://dx.doi.org/10.3390/ijms25021279.
    Open access • Published • 10.3390/ijms25021279
  2. Libório-Ramos, Sofia; Barbosa-Matos, Catarina; Fernandes, Raquel; Borges-Pereira, Caroline; Costa, Sandra. "Interstitial Macrophages Lead Early Stages of Bleomycin-Induced Lung Fibrosis and Induce Fibroblasts Activation". Cells 12 3 (2023): 402. http://dx.doi.org/10.3390/cells12030402.
    Open access • Published • 10.3390/cells12030402
  3. Gonçales, Relber A.; Bastos, Helder Novais; Duarte-Oliveira, Cláudio; Antunes, Daniela; Sokhatska, Oksana; Jacob, Maria; Rolo, Rui; et al. "Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis". American Journal of Respiratory and Critical Care Medicine 206 9 (2022): 1140-1152. http://dx.doi.org/10.1164/rccm.202112-2771oc.
    10.1164/rccm.202112-2771oc
  4. da Silva-Ferreira, Sara; Duarte-Oliveira, Cláudio; Antunes, Daniela; Barbosa-Matos, Catarina; Mendes-Frias, Ana; Torrado, Egídio; Costa, Sandra; et al. "Hypoxia inducible-factor 1 alpha regulates neutrophil recruitment during fungal-elicited granulomatous inflammation". Frontiers in Cellular and Infection Microbiology 12 (2022): http://dx.doi.org/10.3389/fcimb.2022.1005839.
    10.3389/fcimb.2022.1005839
  5. 5819-03DF-2B85; Costa, Sandra; 6719-B9AE-4AB5; FF1C-FC2E-2E27. "PTX3 inhibits complement-mediated metabolic activation of macrophages to restrain granuloma formation in sarcoidosis". American Journal of Respiratory and Critical Care Medicine (2022):
    Accepted
  6. Brito, Pedro S.; Costa, Jorge V.; Barbosa-Matos, Catarina; Costa, Sandra M.; Correia-Pinto, Jorge; Silva, Rufino M.. "ASSOCIATION OF SERUM VASOGENIC AND PROINFLAMMATORY FACTORS WITH CLINICAL RESPONSE TO ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR FOR DIABETIC MACULAR EDEMA". Retina Publish Ah (2020): http://dx.doi.org/10.1097/iae.0000000000002852.
    10.1097/iae.0000000000002852
  7. Gonçalves, Samuel M.; Duarte-Oliveira, Cláudio; Campos, Cláudia F.; Aimanianda, Vishukumar; ter Horst, Rob; Leite, Luis; Mercier, Toine; et al. "Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-16120-z.
    10.1038/s41467-020-16120-z
  8. Pinto, Filipe; Costa, Ângela M; Santos, Gisele C; Matsushita, Marcus M; Costa, Sandra; Silva, Viviane AO; Miranda-Gonçalves, Vera; et al. "The T-box transcription factor brachyury behaves as a tumor suppressor in gliomas". The Journal of Pathology 251 1 (2020): 87-99. http://dx.doi.org/10.1002/path.5419.
    10.1002/path.5419
  9. Viana-Pereira, Marta; Moreno, DA; Linhares, P; Amorim, Julia; Nabiço, Rui; Costa, Sandra; Vaz, R; Reis, Rui Manuel. "Replication of GWAS identifies RTEL1, CDKN2A/B, and PHLDB1 SNPs as risk factors in Portuguese gliomas patients". Molecular Biology Reports (2020): http://dx.doi.org/10.1007/s11033-019-05178-8.
    Published • 10.1007/s11033-019-05178-8
  10. Brito, Pedro; Costa, Jorge; Gomes, Nuno; Costa, Sandra; Correia-Pinto, Jorge; Silva, Rufino. "Serum pro-inflammatory factors as predictors of persistent diabetic macular oedema with limited anatomic response to anti- VEGF : association with intravitreal injection treatment profiles in real-world setting". Acta Ophthalmologica (2019): http://dx.doi.org/10.1111/aos.14308.
    Published • 10.1111/aos.14308
  11. Brito P; Costa J; Gomes N; Costa, Sandra; Correia-Pinto J; Silva R. "Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGF.". Journal of diabetes and its complications (2018): http://europepmc.org/abstract/med/29843962.
    10.1016/j.jdiacomp.2018.05.006
  12. Linhares P; Viana-Pereira M; Ferreira M; Amorim J; Nabiço R; Pinto F; Costa, Sandra; Vaz R; Reis RM. "Genetic variants of vascular endothelial growth factor predict risk and survival of gliomas.". Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (2018): http://europepmc.org/abstract/med/29584591.
    10.1177/1010428318766273
  13. Xavier-Magalhães, A.; Oliveira, A.I.; de Castro, J.V.; Pojo, M.; Gonçalves, C.S.; Lourenço, T.; Viana-Pereira, M.; et al. "Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis". Journal of Neuro-Oncology 132 1 (2017): 27-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009278934&partnerID=MN8TOARS.
    10.1007/s11060-016-2345-0
  14. Finisguerra V; Di Conza G; Di Matteo M; Serneels J; Costa, Sandra; Thompson AA; Wauters E; et al. "MET is required for the recruitment of anti-tumoural neutrophils.". (2015): http://europepmc.org/abstract/med/25985180.
    10.1038/nature14407
  15. Vieira de Castro J; Gonçalves CS; Costa, Sandra; Linhares P; Vaz R; Nabiço R; Amorim J; et al. "Impact of TGF-ß1 -509C/T and 869T/C polymorphisms on glioma risk and patient prognosis.". (2015): http://europepmc.org/abstract/med/25813152.
    10.1007/s13277-015-3343-0
  16. Paskulin, D.D.; Giacomazzi, J.; Achatz, M.I.; Costa, Sandra; Reis, R.M.; Hainaut, P.; Dos Santos, S.E.B.; Prolla, P.A.. "Ancestry of the brazilian TP53 c.1010G>A (p. Arg337His, R337H) Founder mutation: clues from haplotyping of short tandem repeats on chromosome 17p". PLoS ONE 10 11 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84957565447&partnerID=MN8TOARS.
    10.1371/journal.pone.0143262
  17. Pojo, M.; Gonçalves, C.S.; Xavier-Magalhães, A.; Oliveira, A.I.; Gonçalves, T.; Correia, S.; Rodrigues, A.J.; et al. "A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide". Oncotarget 6 10 (2015): 7657-7674. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928404326&partnerID=MN8TOARS.
  18. Pandey, J.P.; Kaur, N.; Costa, Sandra; Amorim, J.; Nabico, R.; Linhares, P.; Vaz, R.; Viana-Pereira, M.; Reis, R.M.. "Immunoglobulin genes implicated in glioma risk". OncoImmunology 3 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84904052382&partnerID=MN8TOARS.
    10.4161/onci.28609
  19. de Mello, R.A.; Ferreira, M.; Soares-Pires, F.; Costa, Sandra; Cunha, J.; Oliveira, P.; Hespanhol, V.; Reis, R.M.. "The Impact of Polymorphic Variations in the 5p15, 6p12, 6p21 and 15q25 Loci on the Risk and Prognosis of Portuguese Patients with Non-Small Cell Lung Cancer". PLoS ONE 8 9 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84883637951&partnerID=MN8TOARS.
    10.1371/journal.pone.0072373
  20. Hamm, A.; Veschini, L.; Takeda, Y.; Costa, Sandra; Delamarre, E.; Squadrito, M.L.; Henze, A.-T.; et al. "PHD2 regulates arteriogenic macrophages through TIE2 signalling". EMBO Molecular Medicine 5 6 (2013): 843-857. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878707647&partnerID=MN8TOARS.
    10.1002/emmm.201302695
  21. De Mello, R.A.; Ferreira, M.; Costa, Sandra; Costa, B.M.; Pires, F.S.; Neves, I.; Almeida, M.I.; et al. "Association between EGF +61 genetic polymorphisms and non-small cell lung cancer increased risk in a Portuguese population: A case-control study". Tumor Biology 33 5 (2012): 1341-1348. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868152951&partnerID=MN8TOARS.
    10.1007/s13277-012-0382-7
  22. Tiburcio, M.; Costa, Sandra; Duarte, M.F.; Schmitt, F.C.; Filho, A.L.. "Characterization of PAR1 and FGFR1 expression in invasive breast carcinomas: Prognostic significance". Oncology Letters 4 4 (2012): 647-657. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864690484&partnerID=MN8TOARS.
    10.3892/ol.2012.806
  23. Marques, H.; Catarino, R.; Domingues, N.; Barros, E.; Portela, C.; Almeida, M.I.; Costa, Sandra; et al. "Detection of the Epstein-Barr virus in blood and bone marrow mononuclear cells of patients with aggressive B-cell non-Hodgkin's lymphoma is not associated with prognosis". Oncology Letters 4 6 (2012): 1285-1289. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867240731&partnerID=MN8TOARS.
    10.3892/ol.2012.913
  24. Araújo, A.P.; Costa, B.M.; Pinto-Correia, A.L.; Fragoso, M.; Ferreira, P.; Mário, D.-R.; Costa, Sandra; Reis, R.M.; Medeiros, R.. "Association between EGF +61A/G polymorphism and gastric cancer in caucasians". World Journal of Gastroenterology 17 4 (2011): 488-492. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955930685&partnerID=MN8TOARS.
    10.3748/wjg.v17.i4.488
  25. Rolny, C.; Mazzone, M.; Tugues, S.; Laoui, D.; Johansson, I.; Coulon, C.; Squadrito, M.L.; et al. "HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF". Cancer Cell 19 1 (2011): 31-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651461701&partnerID=MN8TOARS.
    10.1016/j.ccr.2010.11.009
  26. Costa, B.M.; Viana-Pereira, M.; Fernandes, R.; Costa, Sandra; Linhares, P.; Vaz, R.; Pinheiro, C.; et al. "Impact of EGFR genetic variants on glioma risk and patient outcome". Cancer Epidemiology Biomarkers and Prevention 20 12 (2011): 2610-2617. http://www.scopus.com/inward/record.url?eid=2-s2.0-83055168559&partnerID=MN8TOARS.
    10.1158/1055-9965.EPI-11-0340
  27. Takeda, Y.; Costa, Sandra; Delamarre, E.; Roncal, C.; Leite De Oliveira, R.; Squadrito, M.L.; Finisguerra, V.; et al. "Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis". Nature 479 7371 (2011): 122-126. http://www.scopus.com/inward/record.url?eid=2-s2.0-80455122752&partnerID=MN8TOARS.
    10.1038/nature10507
  28. Albergaria, A.; Paredes, J.; Sousa, B.; Milanezi, F.; Carneiro, V.; Bastos, J.; Costa, Sandra; et al. "Expression of FOXA1 and GATA-3 in breast cancer: The prognostic significance in hormone receptor-negative tumours". Breast Cancer Research 11 3 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-74049137968&partnerID=MN8TOARS.
    10.1186/bcr2327
  29. Costa, Sandra; Pinto, D.; Pereira, D.; Rodrigues, H.; Cameselle-Teijeiro, J.; Medeiros, R.; Schmitt, F.. "XRCC1 Arg399Gln and RAD51 5'UTR G135C polymorphisms and their outcome in tumor aggressiveness and survival of Portuguese breast cancer patients". Breast Cancer Research and Treatment 109 1 (2008): 183-185. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149147370&partnerID=MN8TOARS.
    10.1007/s10549-007-9637-1
  30. Costa, Sandra; Pinto, D.; Pereira, D.; Rodrigues, H.; Cameselle-Teijeiro, J.; Medeiros, R.; Schmitt, F.. "Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancer". BMC Cancer 8 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-39849089291&partnerID=MN8TOARS.
    10.1186/1471-2407-8-32
  31. Costa, Sandra; Schmitt, F.C.. "Opinion on moderate/low cancer genetic risk markers in medical practice including comment on the article Genetic contribution to all cancers: The first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology by Lubinski et al., Breast Cancer Res Treat 2008 Apr 15". Hereditary Cancer in Clinical Practice 6 2 (2008): 64-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-46449089116&partnerID=MN8TOARS.
  32. Lima-Ramos, V.; Pacheco-Figueiredo, L.; Costa, Sandra; Pardal, F.; Silva, A.; Amorim, J.; Lopes, J.M.; Reis, R.M.. "TP53 codon 72 polymorphism in susceptibility, overall survival, and adjuvant therapy response of gliomas". Cancer Genetics and Cytogenetics 180 1 (2008): 14-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749023402&partnerID=MN8TOARS.
    10.1016/j.cancergencyto.2007.08.019
  33. Pinto, D.; Pereira, D.; Vasconcelos, A.; Afonso-Lopes, C.; Osório, T.; Lopes, C.; Medeiros, R.. "Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer". Cancer Letters 246 1-2 (2007): 324-330. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845623812&partnerID=MN8TOARS.
    10.1016/j.canlet.2006.03.014
  34. Costa, Sandra; Pinto, D.; Pereira, D.; Rodrigues, H.; Cameselle-Teijeiro, J.; Medeiros, R.; Schmitt, F.. "DNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: A study on a Portuguese population". Breast Cancer Research and Treatment 103 2 (2007): 209-217. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249074107&partnerID=MN8TOARS.
    10.1007/s10549-006-9364-z
  35. Costa, B.M.; Ferreira, P.; Costa, Sandra; Canedo, P.; Oliveira, P.; Silva, A.; Pardal, F.; et al. "Association between functional EGF+61 polymorphism and glioma risk". Clinical Cancer Research 13 9 (2007): 2621-2626. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249104304&partnerID=MN8TOARS.
    10.1158/1078-0432.CCR-06-2606
  36. Longatto Filho, A.; Costa, Sandra; Milanezi, F.; Montruccoli, D.; Montruccoli, G.C.; Baltazar, F.; Schmitt, F.C.. "Immunohistochemical expression of VEGF-A and its ligands in non-neoplastic lesions of the breast sampling-assisted by dynamic angiothermography". Oncology Reports 18 5 (2007): 1201-1206. http://www.scopus.com/inward/record.url?eid=2-s2.0-38449116944&partnerID=MN8TOARS.
  37. Costa, Sandra; Pinto, D.; Morais, A.; Vasconcelos, A.; Oliveira, J.; Lopes, C.; Medeiros, R.. "Acetylation genotype and the genetic susceptibility to prostate cancer in a Southern European population". Prostate 64 3 (2005): 246-252. http://www.scopus.com/inward/record.url?eid=2-s2.0-22144462833&partnerID=MN8TOARS.
    10.1002/pros.20241
  38. Filho, A.L.; Martins, A.; Costa, Sandra; Schmitt, F.C.. "VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels". Pathology Research and Practice 201 2 (2005): 93-99. http://www.scopus.com/inward/record.url?eid=2-s2.0-15944372668&partnerID=MN8TOARS.
    10.1016/j.prp.2004.11.008
  39. Dufloth, R.M.; Costa, Sandra; Schmitt, F.; Zeferino, L.C.. "DNA repair gene polymorphisms and susceptibility to familial breast cancer in a group of patients from Campinas, Brazil.". Genetics and molecular research : GMR 4 4 (2005): 771-782. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745012392&partnerID=MN8TOARS.
  40. Medeiros, R.; Vasconcelos, A.; Costa, Sandra; Pinto, D.; Ferreira, P.; Lobo, F.; Morais, A.; Oliveira, J.; Lopes, C.. "Metabolic Susceptibility Genes and Prostate Cancer Risk in a Southern European Population: The Role of Glutathione S-Transferases GSTM1, GSTM3, and GSTT1 Genetic Polymorphisms". Prostate 58 4 (2004): 414-420. http://www.scopus.com/inward/record.url?eid=2-s2.0-1542377512&partnerID=MN8TOARS.
    10.1002/pros.10348
  41. Craveiro, R.; Costa, Sandra; Pinto, D.; Salgado, L.; Carvalho, L.; Castro, C.; Bravo, I.; et al. "TP73 alterations in cervical carcinoma". Cancer Genetics and Cytogenetics 150 2 (2004): 116-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-11144357830&partnerID=MN8TOARS.
    10.1016/j.cancergencyto.2003.08.020
  42. Medeiros, R.; Vasconcelos, A.; Costa, Sandra; Pinto, D.; Lobo, F.; Morais, A.; Oliveira, J.; Lopes, C.. "Linkage of angiotensin I-converting enzyme gene insertion/deletion polymorphism to the progression of human prostate cancer". Journal of Pathology 202 3 (2004): 330-335. http://www.scopus.com/inward/record.url?eid=2-s2.0-1542375102&partnerID=MN8TOARS.
    10.1002/path.1529
  43. Pinto, D.; Vasconcelos, A.; Costa, Sandra; Pereira, D.; Rodrigues, H.; Lopes, C.; Medeiros, R.. "HER2 polymorphism and breast cancer risk in Portugal". European Journal of Cancer Prevention 13 3 (2004): 177-181. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942666198&partnerID=MN8TOARS.
    10.1097/01.cej.0000130015.91525.c7
  44. Ribeiro, R.; Vasconcelos, A.; Costa, Sandra; Pinto, D.; Morais, A.; Oliveira, J.; Lobo, F.; Lopes, C.; Medeiros, R.. "Overexpressing Leptin Genetic Polymorphism (-2548 G/A) Is Associated with Susceptibility to Prostate Cancer and Risk of Advanced Disease". Prostate 59 3 (2004): 268-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942507889&partnerID=MN8TOARS.
    10.1002/pros.20004
  45. Ferreira, P.M.; Medeiros, R.; Vasconcelos, A.; Costa, Sandra; Pinto, D.; Morais, A.; Oliveira, J.; Lopes, C.. "Association between CYP2E1 polymorphisms and susceptibility to prostate cancer". European Journal of Cancer Prevention 12 3 (2003): 205-211. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037502788&partnerID=MN8TOARS.
    10.1097/00008469-200306000-00007
  46. Medeiros, R.; Vasconcelos, A.; Costa, Sandra; Pinto, D.; Morais, A.; Oliveira, J.; Lopees, C.. "Steroid hormone genotypes ARStuI and ER325 are linked to the progression of human prostate cancer". Cancer Genetics and Cytogenetics 141 2 (2003): 91-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037373237&partnerID=MN8TOARS.
    10.1016/S0165-4608(02)00660-X
  47. Medeiros, R.; Pereira, D.; Afonso, N.; Palmeira, C.; Faleiro, C.; Afonso-Lopes, C.; Freitas-Silva, M.; et al. "Platinum/paclitaxel-based chemotherapy in advanced ovarian carcinoma: Glutathione S-transferase genetic polymorphisms as predictive biomarkers of disease outcome". International Journal of Clinical Oncology 8 3 (2003): 156-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042305238&partnerID=MN8TOARS.
    10.1007/s10147-003-0318-8
  48. Medeiros, R.; Morais, A.; Vasconcelos, A.; Costa, Sandra; Pinto, D.; Oliveira, J.; Carvalho, R.; Lopes, C.. "Linkage between polymorphisms in the prostate specific antigen ARE1 gene region, prostate cancer risk, and circulating tumor cells". Prostate 53 1 (2002): 88-94. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037106039&partnerID=MN8TOARS.
    10.1002/pros.10135
  49. Costa, Sandra; Medeiros, R.; Vasconcelos, A.; Pinto, D.; Lopes, C.. "A slow acetylator genotype associated with an increased risk of advanced cervical cancer". Journal of Cancer Research and Clinical Oncology 128 12 (2002): 678-682. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036458259&partnerID=MN8TOARS.
    10.1007/s00432-002-0391-9
  50. Medeiros, R.; Morais, A.; Vasconcelos, A.; Costa, Sandra; Pinto, D.; Oliveira, J.; Lopes, C.. "The role of vitamin D receptor gene polymorphisms in the susceptibility to prostate cancer of a southern European population". Journal of Human Genetics 47 8 (2002): 413-418. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036336854&partnerID=MN8TOARS.
  51. Medeiros, R.; Morais, A.; Vasconcelos, A.; Costa, Sandra; Pinto, D.; Oliveira, J.; Lopes, C.; Carrilho, S.. "Endothelial nitric oxide synthase gene polymorphisms and genetic susceptibility to prostate cancer". European Journal of Cancer Prevention 11 4 (2002): 343-350. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036685839&partnerID=MN8TOARS.
    10.1097/00008469-200208000-00005
  52. Medeiros, R.M.; Morais, A.; Vasconcelos, A.; Costa, Sandra; Pinto, D.; Oliveira, J.; Ferreira, P.; Lopes, C.. "Outcome in prostate cancer: Association with endothelial nitric oxide synthase Glu-Asp298 polymorphism at Exon 7". Clinical Cancer Research 8 11 (2002): 3433-3437. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036850208&partnerID=MN8TOARS.
Thesis / Dissertation
  1. Costa, Sandra. "DNA repair genetic polymorphisms and breast cancer in a Portuguese population". PhD, Universidade do Minho Escola de Medicina, 2007.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/11 Macrófagos: Afinal qual o papel desta população celular? IX Ciclo de Conferências Cientificas para professores de Biologia e Físico-Química do Ensino Básico e Secundário
Formação Continua de Professores. (Portugal)
2019/05/27 Regulation of pulmonary fibrosis by hepatocyte growth factor receptor signaling Molecular mechanisms of tissue injury, repair and fibrosis
EMBO|FEBS Lecture Course (Spetses, Greece)
2019/05/21 Macrophages as modulators of lung development and disease iBiMED Seminars
iBiMED, Universidade de Aveiro (Aveiro, Portugal)
2019/05/10 Critical factors in lung morphogenesis and fibrosis The frontiers of research in ILD
International Programme of Advanced Courses, School of Medicine, Minho University (Braga, Portugal)
2019/03 Cultura de pulmão embrionário de ratinho - Workshop I Jornadas de Ciência
Escola de Ciencias Universidade do Minho (Portugal)
2018/11 c-Met deletion attenuates lung fibrosis by modulation of immune cells recruitment XXXIV Congresso Nacional de Pneumologia
Sociedade Portuguesa de Pneumologia (Loulé, Portugal)
2018/11 Fetal lung tissue macrophages as key players in lung morphogenesis XXXIV Congresso Nacional de Pneumologia
Sociedade Portuguesa de Pneumologia (Loulé, Portugal)
2018/05 Dietary zinc supplementation promotes tumor overgrowth through a microbiota-tumor axis XLIV Annual Meeting of the Portuguese Society of Immunology
Sociedade Portuguesa Imunologia (Lisboa, Portugal)
2017/04 O pulmão embrionário de ratinho - Workshop X Encontro Nacional de Estudantes de Bioquimica,
Associação Nacional de estudantes de Bioquímica (Portugal)
2017/04 A experimentação animal – Mesa Redonda X Encontro Nacional de Estudantes de Bioquimica
Associação de Estudantes de Bioquímica (Portugal)
2016/05 Da cultura de células à cultura de explantes de orgão no estudo do desenvolvimento do pulmão de ratinho I Ciclo de Seminários em Biotecnologia: Biotecnologia da Saúde
Escola Superior Agrária, Instituto Politécnico de Viana do Castelo (Portugal)
2016/02 Cultura de explantes de pulmão embrionário de ratinho - Workshop XVII Jornadas de Biologia Aplicada
Escola de Ciencias da Universidade do Minho (Portugal)
2015/02 Cultura de explantes de pulmão embrionário de ratinho - Workshop XVI Jornadas de Biologia Aplicada
Escola de Ciencias da universidade do Minho (Portugal)
2013/11 Regulação da morfologia da via aérea e angiogénese pulmonar fetal por macrófagos tecidulares 14º Congresso Nacional Pediatria
Sociedade Portuguesa de Pediatria (Porto, Portugal)
2013/04 Blood vessels as orchestrators of tumoral development IV Jornadas de Ciência e Medicina
NENUM, Escola de Medicina (Braga, Portugal)
2012/04 Vascularization III Jornadas de Ciência e Medicina
NEMUM, Escola de Medicina (Braga, Portugal)
2002/02 DNA repair genes and Implication to Breast cancer susceptibility and chemotherapy X Jornadas de Senologia
Sociedade Portuguesa de Senologia (Tomar, Portugal)
2000/11 NAT2 polymorphisms and Breast cancer susceptibility Congresso Nacional de Senologia
Sociedade Portuguesa de Senologia (Aveiro, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018/05 - 2024/12 Macrophages secretome: a novel therapeutic strategy for lung maturation and repair
Supervisor
 Applied Health Sciences (PhD)
Universidade do Minho Escola de Medicina, Portugal
2019/09 - 2024/08 Immunoregulatory role of c-Met in pulmonary fibrosis progression
Supervisor
 Health Sciences (PhD)
Universidade do Minho Escola de Medicina, Portugal
2020/09 - 2022/07 Fetal lung macrophage-derived secretome in the modulation of lung differentiation
Supervisor
 Mestrado em Ciências da Saúde (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/04 - 2021/09 Cancer cell-macrophage metabolic symbiosis: unravelling the role of monocarboxylate transporters (MCTs)
Co-supervisor
 Post-doctoral (Other)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/09 - 2021/08 Microbiota regulation of cancer immune surveillance
Co-supervisor
 Health Sciences (PhD)
Universidade do Minho Escola de Medicina, Portugal
2019/06 - 2019/12 The role of GSK-3ß inhibition in lung injury
Supervisor
 Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal
2018/06 - 2019/12 Macrophages in pulmonary fibrosis: characterization and fibroblasts transdifferentiation modulation
Supervisor
 Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal
2017/06 - 2018/09 Lung injury modulation by c-met-expressing immune cells
Supervisor
 Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal
2016/06 - 2017/10 Lung epithelial and vascular development modulation by tissue macrophages
Supervisor
 Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal
2012/06 - 2013/09 Relevance of tissue macrophages in lung development
Supervisor
 Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018/05 - 2019/05/10 Research symposium "The Frontiers of Research in Interstital Lung Diseases", integrated in the International Programme of Advanced Courses, School of Medicine, Minho University, (2019/05/10 - 2019/05/10)
Symposium (Member of the Scientific Committee)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020/07/23 Tackling metabolism in cancer cells: implications for gastrointestinal cancer therapy
(Thesis) Arguer
 Ricardo Luís Agra de Amorim (PhD)
Universidade do Minho Escola de Medicina, Portugal
2019/06/17 Intercellular relationships in the tumor microenvironment: implications for cancer pathophysiology
(Thesis) Arguer
 Ana Isabel Ferreira de Oliveira (PhD)
Universidade do Minho Escola de Medicina, Portugal
2018/12 Unravel the role of hypoxia in the tumor microenvironment: a focus on macrophage-cancer cell interplay
(Thesis) Main arguer
 Rosa Oliveira (Master)
Universidade do Minho Escola de Ciências, Portugal
2017/11 Interplay between molecular and cellular players on glioma pathophysiology
(Thesis) Arguer
 Joana Isabel Martins Cosme Vieira de Castro (PhD)
Universidade do Minho Escola de Medicina, Portugal

Association member

Society Organization name Role
2020 - Current European Respiratory Society
2019 - Current Sociedade Portuguesa de Pneumologia
2015 - Current Sociedade Portuguesa de Imunologia

Committee member

Activity description
Role 		Institution / Organization
2013/10 - 2021/12/31 ICVS International Seminars, two edition/year (Spring and Autumn) ICVS, School of Medicine, Minho University, Braga, Portugal
Member
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2013 - 2022 FUNDAMENTALS OF GENETICS, DEVELOPMENT AND NEOPLASIA FUNDAMENTALS OF GENETICS, DEVELOPMENT AND NEOPLASIA (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2017/05/15 - 2017/06/02 Molecular and Cellular Analysis: essential toolkit for in vitro cell cultures, gene expression and microscopy Ciências da Saúde (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2009/02/06 - 2009/02/24 Animal Cell and Tissue Culture: from basic principles to advanced techniques Animal Cell and Tissue Culture: from basic principles to advanced techniques (Mestrado) Universidade do Minho Escola de Medicina, Portugal
Distinctions

Other distinction

2014 FCT Investigator Programme
2011 Post-Doctoral fellowship
2007 Post-Doctoral fellowship