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Clarinda Costa Sequeira is a Senior postdoctoral researcher at Bernal Institute, University of Limerick in Ireland. In March 2023, Clarinda got her European Ph.D. from NOVA University of Lisbon, University of Aveiro, and University of Porto. Clarinda got her MSc. degree in Chemical and Biochemical Engineering from NOVA University of Lisbon in 2016. In 2018, she visited Santos' Lab at the University of Helsinki (Finland), for 6 months, to develop biopharmaceutical-loaded liposomes using microfluidics. Clarinda (h-index 8) has 11 articles published in peer-reviewed journals (10 published in Q1 journals) and participated in several international conferences (8 oral presentations and 17 poster communications). In 2022, Clarinda was awarded the best oral presentation at the 13th International Symposium of Supercritical Fluids, in Montréal (Canada). During her Ph.D., Clarinda supervised more than 10 students. Her research relies on continuous manufacturing, liposomes, supercritical carbon dioxide, polymers, chemical engineering, microfluidics, nanomedicines, and pulmonary drug administration. Clarinda is also a member of the Portuguese Chemical Society
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Identification

Personal identification

Full name
Clarinda Isabel da Silva e Costa Sequeira

Citation names

  • Costa, Clarinda

Author identifiers

Ciência ID
9E15-DE78-D70A
ORCID iD
0000-0003-0873-8934

Email addresses

  • Clarinda.Sequeira@ul.ie (Professional)

Websites

  • padrelagroupul.ie/research-team/ (Professional)

Knowledge fields

  • Exact Sciences - Chemical Sciences - Polymer Science
  • Engineering and Technology - Chemical Engineering - Chemical Process Engineering
  • Engineering and Technology - Nano-technology - Nano-materials

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Portuguese (Mother tongue)
Education
Degree Classification
2018 - 2023
Concluded
 Sustainable Chemistry (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade do Porto, Portugal

Universidade de Aveiro, Portugal
"Integrated manufacture of liposomal dry powder formulations" (THESIS/DISSERTATION)
 Approved - Europrean doctorate
2011/09/21 - 2016/11/11
Concluded
 Chemical & Biochemical Engineering (Mestrado integrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 16/20
Affiliation

Others

Category
Host institution 		Employer
2018/04/01 - 2023/03/30 PhD Student Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2016/10/03 - 2018/03/31 Research Fellow Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Outputs

Publications

Conference poster
  1. Costa, Clarinda; Beatriz Nobre; Ana Sofia Matos; Ana Sofia Silva; Casimiro, Teresa; Corvo, Maria Luísa; Aguiar-Ricardo, Ana. "Hydrophilic molecule-loaded liposomal dry powder formulations using supercritical CO2 - assisted spray-drying". Paper presented in 4th International Caparica Christmas Conference on Translational Chemistry 2021, 2021.
  2. Costa, Clarinda; Liu, Zehua; Sandra I. Simões; Alexandra Correia; Antti Rahikkala; Jani Seitsonen; Janne Ruokolainen; et al. Corresponding author: Costa, Clarinda. "Integrated manufacture of liposomal dry powder formulations for pulmonary enzyme delivery: When pharmaceutical technology meets green chemistry". Paper presented in 18th European Meeting on Supercritical Fluids, 2021.
  3. Costa, Clarinda; Beatriz Nobre; Ana Sofia Matos; Casimiro, Teresa; Corvo, Maria Luísa; Aguiar-Ricardo, Ana. Corresponding author: Costa, Clarinda. "Supercritical CO2 applied on the production of liposomal dry powder formulations". Paper presented in 1st International GREENERING Conference, 2021.
  4. Costa, Clarinda; Liu, Zehua; Sandra I. Simões; Alexandra Correia; Antti Rahikkala; Jani Seitsonen; Janne Ruokolainen; et al. "Microfluidics production of enzyme-loaded liposomes towards the treatment of inflammatory diseases". Paper presented in III International Conference NOVAhealth Chronic Disease and Infection, 2020.
  5. Costa, Clarinda; Liu, Zehua; João P. Martins; Alexandra Correia; Figueiredo, Patrícia; Antti Rahikkala; Li, Wei; et al. "Continuous microfluidic assembly of insulin-loaded pH response nano-in- microparticles: towards to insulin oral delivery". Paper presented in IIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  6. Francisco Sacarrão; Costa, Clarinda; Casimiro, Teresa; Aguiar-Ricardo, Ana; João Paulo Borges; Jorge C. Silva; M. Carmo Lança. Corresponding author: M. Carmo Lança. "Porous mats of piezoelectric PVDF produced by supercritical CO 2 assisted phase inversion for bone tissue engineering". Paper presented in Materiais 2019, 2019.
  7. Costa, Clarinda; Guilherme Morais; Miguel Mates; Branco, Paula S.; Susana P. Gaudêncio; Rita G. Sobral; Grilo, Inês R.; et al. "Dry Powder Formulations for Antibiotic Pulmonary Delivery". Paper presented in 6th Portuguese Young Chemists Meeting, 2018.
  8. Miguel Mateus ; Guilherme Morais; Costa, Clarinda; Branco, Paula S.; Grilo, Inês R.; Rita G. Sobral; Susana P. Gaudêncio; Bonifácio, Vasco D.B.; Aguiar-Ricardo, Ana. "One-Pot reaction: A sustainable and green approach for drug modification". Paper presented in 6th Portuguese Young Chemists Meeting, 2018.
  9. Costa, Clarinda; Guilherme Morais; Miguel Mateus ; Branco, Paula S.; Susana P. Gaudêncio; Rita G. Sobral; Grilo, Inês R.; et al. "Development of Dry Powder Formulations Containing Antibacterial Compounds". Paper presented in 12th International Symposium on Supercritical Fluids, 2018.
  10. Costa, Clarinda; Adeoye, Oluwatomide; Casimiro, Teresa; Cabral-Marques, Helena; Aguiar-Ricardo, Ana. "Drug/cyclodextrin inclusion complexes for potential pulmonary drug delivery". Paper presented in 2nd International Caparica Christmas Congress on Translational Chemistry, 2017.
  11. Costa, Clarinda; Guilherme Morais; Correia, Vanessa G.; Rita F. Pires; M. Gomes de Pinho; Bonifácio, Vasco D.B.; Casimiro, Teresa; Aguiar-Ricardo, Ana. Corresponding author: Aguiar-Ricardo, Ana. "Poly(2-oxazoline)s derivatives and conjugates for drug delivery and antimicrobial fighting". Paper presented in 2nd International Caparica Christmas Congress on Translational Chemistry, 2017.
  12. Costa, Clarinda; Adeoye, Oluwatomide; Casimiro, Teresa; Cabral-Marques, Helena; Aguiar-Ricardo, Ana. "Development of drug/cyclodextrins inclusion complexes using Supercritical CO2-Assisted Spray Drying". Paper presented in International Symposium on Bioinspired Macromolecular Systems, 2017.
  13. Costa, Clarinda; Casimiro, Teresa; Aguiar-Ricardo, Ana. "Quality-by-Design approach towards a sustainable optimization of supercritical CO2 spray drying". Paper presented in 3 rd EuCheMS Congress on Green and Sustainable Chemistry, 2017.
  14. Costa, Clarinda; Bruno Branco ; Kostadin Petrov; Casimiro, Teresa; Aguiar-Ricardo, Ana. "A Quality-by-Design approach towards the optimization of supercritical CO2 spray drying". Paper presented in 16th European Meeting on Supercritical Fluids, 2017.
  15. Fabiana G. Santos; Patrícia I. Morgado; Costa, Clarinda; Bonifácio, Vasco D.B.; Sandra Einloft; Aguiar-Ricardo, Ana; Rosane Ligabue. "Polyurethane porous scaffolds obtained by leaching and scCO2 techniques,". Paper presented in 2nd EuCheMS Congress on Green and Sustainable Chemistry, Faculdade de Ciências e Tecnologia, 2015.
Journal article
  1. Costa, Clarinda; Anselmo, Hugo; Ferro, Rita; Matos, Ana Sofia; Casimiro, Teresa; Aguiar-Ricardo, Ana. "Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying". Molecules 27 6 (2022): 2001. http://dx.doi.org/10.3390/molecules27062001.
    10.3390/molecules27062001
  2. Costa, Clarinda; Casimiro, Teresa; Corvo, Maria Luísa; Aguiar-Ricardo, Ana. "Solid Dosage Forms of Biopharmaceuticals in Drug Delivery Systems Using Sustainable Strategies". Molecules 26 24 (2021): 7653. http://dx.doi.org/10.3390/molecules26247653.
    Published • 10.3390/molecules26247653
  3. Clarinda Costa; Beatriz Nobre; Ana Sofia Matos; Ana Sofia Silva; Teresa Casimiro; Maria Luísa Corvo; Ana Aguiar-Ricardo. "Inhalable hydrophilic molecule-loaded liposomal dry powder formulations using supercritical CO2 – assisted spray-drying". Journal of CO2 Utilization 53 (2021): 101709-101709. https://doi.org/10.1016/j.jcou.2021.101709.
    10.1016/j.jcou.2021.101709
  4. Costa, Clarinda; Liu, Zehua; Simões, Sandra; Correia, Alexandra; Rahikkala, Antti; Seitsonen, Jani; Ruokolainen, Janne; et al. "One-step microfluidics production of enzyme-loaded liposomes for the treatment of inflammatory diseases". Colloids and Surfaces B: Biointerfaces (2020): 111556. http://dx.doi.org/10.1016/j.colsurfb.2020.111556.
    10.1016/j.colsurfb.2020.111556
  5. Costa, Clarinda; Liu, Zehua; Martins, João P.; Correia, Alexandra; Figueiredo, Patrícia; Rahikkala, Antti; Li, Wei; et al. "All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery". Biomaterials Science (2020): http://dx.doi.org/10.1039/d0bm00743a.
    Published • 10.1039/d0bm00743a
  6. Aragón, Javier; Costa, Clarinda; Coelhoso, Isabel; Mendoza, Gracia; Aguiar-Ricardo, Ana; Irusta, Silvia. "Electrospun asymmetric membranes for wound dressing applications". Materials Science and Engineering: C 103 (2019): 109822. http://dx.doi.org/10.1016/j.msec.2019.109822.
    10.1016/j.msec.2019.109822
  7. Adeoye, Oluwatomide; Costa, Clarinda; Casimiro, Teresa; Aguiar-Ricardo, Ana; Cabral-Marques, Helena. "Preparation of ibuprofen/hydroxypropyl-¿-cyclodextrin inclusion complexes using supercritical CO2-assisted spray drying". The Journal of Supercritical Fluids 133 (2018): 479-485. http://dx.doi.org/10.1016/j.supflu.2017.11.009.
    10.1016/j.supflu.2017.11.009
  8. Costa, Clarinda; Casimiro, Teresa; Aguiar-Ricardo, Ana. "Optimization of Supercritical CO2-Assisted Atomization: Phase Behavior and Design of Experiments". Journal of Chemical & Engineering Data 63 4 (2018): 885-896. http://dx.doi.org/10.1021/acs.jced.7b00820.
    10.1021/acs.jced.7b00820
  9. Tavares, Márcia; Cabral, Renato P.; Costa, Clarinda; Martins, Pedro; Fernandes, Alexandra R.; Casimiro, Teresa; Aguiar-Ricardo, A.. "Development of PLGA dry powder microparticles by supercritical CO 2 -assisted spray-drying for potential vaccine delivery to the lungs". The Journal of Supercritical Fluids 128 (2017): 235-243. http://dx.doi.org/10.1016/j.supflu.2017.06.004.
    10.1016/j.supflu.2017.06.004
  10. Silva, A. Sofia; Sousa, Ana M.; Cabral, Renato P.; Silva, Marta C.; Costa, Clarinda; Miguel, Sónia P.; Bonifácio, Vasco D.B.; et al. "Aerosolizable gold nano-in-micro dry powder formulations for theragnosis and lung delivery". International Journal of Pharmaceutics 519 1-2 (2017): 240-249. http://dx.doi.org/10.1016/j.ijpharm.2017.01.032.
    10.1016/j.ijpharm.2017.01.032
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/04/12 Integrated manufacture of liposomal dry powder formulations LAQV-Requimte Webinar
LAQV (Portugal)
2022/03/01 Manufacturing of liposomal-loaded hydrophilic or hydrophobic drugs dry powder formulations using supercritical carbon dioxide 2º Encontro Ibérico de Fluídos Supercríticos
Green and Sustainable Processes Lab; Flucomp; I+D Farma research group; PRODEQ (Coimbra)
2021/12/06 Hydrophilic molecule-loaded liposomal dry powder formulations using supercritical CO2 - assisted spray-drying 4th International Caparica Christmas Conference on Translational Chemistry
(Portugal)
2021/05/21 Development Of Hydrophilic Molecules- Loaded Liposomal Dry Powder Formulations Using Supercritical Carbon Dioxide: The Future Of Inhalable Vaccines? 7th Portuguese Young Chemists Meeting
2021/05/04 Integrated manufacture of liposomal dry powder formulations for pulmonary enzyme delivery: When pharmaceutical technology meets green chemistry 18 th European Meeting on Supercritical Fluids
(France)
2019/04/16 Dry powders formulations for chronic inflammatory lung therapy Materiais 2019
(Portugal)
2017/10/06 Preparation of Ibuprofen/hydroxypropyl-gamma-cyclodextrin inclusion complexes using supercritical CO2-assisted spray-drying 5th European Conference on Cyclodextrins
Faculdade de Farmácia, Universidade de Lisboa
2017/09/05 A Quality-by-Design approach towards the optimization of supercritical CO2 spray drying 3 rd EuCheMS Congress on Green and Sustainable Chemistry
(United Kingdom)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/12/01 - Current Development and optimization of Supercritical CO2- Assisted Spray Drying process towards liposomal dry powders formulations
Co-supervisor of Beatriz Nobre

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2015/02/06 - 2015/02/06 Technological days: JorTec 2015- Jornadas Tecnológicas 2015 (2015/02/06)
Conference (President of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Association member

Society Organization name Role
2018/04/01 - Current Portuguese Chemical Society
2014 - 2016 Chemical Engineering Students Core

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/02/09 - Current Project Management Curso de doutoramento (conclusão de unidades curriculares)) Universidade Nova de Lisboa Escola Nacional de Saúde Pública, Portugal
2018/06/08 - Current Microfluidics and Nanotechnology in Pharmaceutical Applications (MiNaPharmA) Helsingin yliopisto, Finland
2017/11 - Current Value Cration Wheel Curso de doutoramento (conclusão de unidades curriculares))
2020/01/15 - 2020/03/25 Science Entrepreneurship Curso de doutoramento (conclusão de unidades curriculares)) NOVA IMS Information management school, Portugal
Distinctions

Award

2022 Best oral presentation