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João Silva completed the Masters in Molecular Biology and Genetics in 2018 with a final grade of 16 values and a Degree in Biology in 2016 with a final grade of 14 values, both by the Faculty of Sciences of the University of Lisbon. Currently attends the PhD in Ciências Biomédicas by Cooperativa de Ensino Superior Politécnico e Universitário. Published 6 articles in scientific journals. A book chapter have been recently accepted. Furthermore two more articles have been submited. Participated in various congresses: EU Cost Action FA1306 with 2 posters, in 2017, Microbiotec with 1 poster, in 2019, I/II Congresso Internacional da TOXRUN with 1 poster, in 2022 and 2023, 4th ENJIO with 1 poster, in 2022, and UNIPRO with a oral presentation, in 2023. Participated as Master Student Fellow in the project "An RNA-based approach to bacterial infection: The function of PNPase and regulatory noncoding RNAs in Listeria virulence" and as a PhD student in the projects "The second-generation antimitotics: a second chance?", "Studies of molecular mechanisms of flavonoid derivatives with potential antitumor activity", "Overcoming paclitaxel resistance in ovarian cancer", "Sneaking Around Science: Promoting Health Scientific Literacy in Preschool" and "Boosting the Efficacy of Emerging Mitosistargeted Antitumor Therapies".
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Identification

Personal identification

Full name
João Silva

Citation names

  • Silva, João Pedro Nunes

Author identifiers

Ciência ID
9F12-598E-DFB5
ORCID iD
0000-0003-4455-4286
Google Scholar ID
https://scholar.google.com/citations?user=kr8dpB8AAAAJ&hl=pt-PT
Researcher Id
AAI-1440-2021

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1) Elementary (A2)
Education
Degree Classification
2021/01/25 - 2025
Ongoing
 Ciências Biomédicas (Doutoramento)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
"The Second-generation of antimitotics: mechanistic insights into the anticancer activity and therapeutic potential " (THESIS/DISSERTATION)
2022/04/13 - 2022/04/13
Concluded
 Chemidoc Imaging System - Bio-Rad (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2016 - 2018/11/14
Concluded
 Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Engineering low-noise gene expression systems for single-molecule experiments" (THESIS/DISSERTATION)
 16
2013 - 2016/07/15
Concluded
 Biologia (Licenciatura)
Major in Biologia Molecular e Genética
Universidade de Lisboa Faculdade de Ciências, Portugal
 14
Projects

Grant

Designation Funders
2019/07/01 - 2020/02/29 An RNA-based approach to bacterial infection: The function of PNPase and regulatory noncoding RNAs in Listeria virulence
026/BI/2019
Master Student Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2025 - Current Science for Little Ones: Promoting Health Literacy in Preschool
2023.12980.PEX
PhD Student Fellow
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
 Fundação para a Ciência e a Tecnologia
Submitted
2023 - Current Antimitóticos de segunda geração (SGAs) em foco: uma segunda oportunidade para aumentar sua eficácia no tratamento do câncer de pulmão
443778/2023-0
PhD Student Fellow
Not funded
2024 - 2025 Sneaking Around Science: Promoting Health Scientific Literacy in Preschool
SciPre.com_GI2- CESPU-2023
PhD Student Fellow
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Ongoing
2024 - 2025 Boosting the Efficacy of Emerging Mitosistargeted Antitumor Therapies
BeatCancer_GI2- CESPU-2023
PhD Student Fellow
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Ongoing
2022/10 - 2023/10 Overcoming paclitaxel resistance in ovarian cancer
upPTXovcar-GI2-CESPU-2022
PhD Student Fellow
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Ongoing
2022/10 - 2023/10 The second-generation antimitotics: a second chance?
SGA4Cancer-GI2-CESPU-2022
PhD Student Fellow
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Ongoing
2022/10 - 2023/10 Studies of molecular mechanisms of flavonoid derivatives with potential antitumor activity
Flav4Tumor-GI2-CESPU-2022
PhD Student Fellow
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Ongoing
Outputs

Publications

Book chapter
  1. Silva, Patrícia M. A.; Silva, João Pedro Nunes; Pinto, Bárbara; Bousbaa, Hassan. "Time-lapse Imaging to Analyze Cell Fate in response to Antimitotics. (Accepted, to be published in the lab protocol series Methods in Molecular Biology, published by Springer Nature).". 2024.
    Accepted
Encyclopedia entry
  1. Silva, João Pedro Nunes; Pinto, Bárbara; Silva, Patrícia M. A.; Monteiro, Luís; Bousbaa, Hassan. "Combination Therapy to Fight Oral Cancer". In Scholarly Community Encyclopedia. MDPI, 2023. https://encyclopedia.pub/entry/45284.
    Published
Journal article
  1. Diana Luísa Almeida-Nunes; João P. N. Silva; Mariana Nunes; Patrícia M. A. Silva; Ricardo Silvestre; Ricardo Jorge Dinis-Oliveira; Hassan Bousbaa; Sara Ricardo. "Metformin Impairs Linsitinib Anti-Tumor Effect on Ovarian Cancer Cell Lines". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms252211935.
    10.3390/ijms252211935
  2. Mafalda Calheiros-Lobo; João P. N. Silva; Leonor Delgado; Bárbara Pinto; Luís Monteiro; Carlos Lopes; Patrícia M. A. Silva; Hassan Bousbaa. "Targeting the EGFR and Spindle Assembly Checkpoint Pathways in Oral Cancer: A Plausible Alliance to Enhance Cell Death". Cancers (2024): https://doi.org/10.3390/cancers16223732.
    10.3390/cancers16223732
  3. Mafalda Calheiros-Lobo; João P. N. Silva; Bárbara Pinto; Luís Monteiro; Patrícia M. A. Silva; Hassan Bousbaa. "Exploring the Therapeutic Implications of Co-Targeting the EGFR and Spindle Assembly Checkpoint Pathways in Oral Cancer". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16091196.
    10.3390/pharmaceutics16091196
  4. João P. N. Silva; Bárbara Pinto; Luís Monteiro; Patrícia M. A. Silva; Hassan Bousbaa. "Coupling Kinesin Spindle Protein and Aurora B Inhibition with Apoptosis Induction Enhances Oral Cancer Cell Killing". Cancers (2024): https://doi.org/10.3390/cancers16112014.
    Published • 10.3390/cancers16112014
  5. Silva, Patrícia M. A.; Henriques, Ana C.; Silva, João Pedro Nunes; Pinto, Bárbara; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Targeting p31comet to Enhance Cisplatin-induced Cytotoxicity in Oral Squamous Cell Carcinoma Cells". Scientific Letters (2024):
    Published • 10.48797/sl.2024.121
  6. Henriques, Ana C.; Pinto, Bárbara; Silva, João Pedro Nunes; Silva, Patrícia M. A.; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Exploring the clinical relevance of p31comet in Head and Neck Squamous Cell Carcinoma through UALCAN database analysis". Scientific Letters (2024):
    Published • 10.48797/sl.2024.266
  7. Bárbara Pinto; João P. N. Silva; Patrícia M. A. Silva; Daniel José Barbosa; Bruno Sarmento; Juliana Carvalho Tavares; Hassan Bousbaa. "Maximizing Anticancer Response with MPS1 and CENPE Inhibition Alongside Apoptosis Induction". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics16010056.
    10.3390/pharmaceutics16010056
  8. João P. N. Silva; Bárbara Pinto; Luís Monteiro; Patrícia M. A. Silva; Hassan Bousbaa. "Combination Therapy as a Promising Way to Fight Oral Cancer". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15061653.
    10.3390/pharmaceutics15061653
  9. Maria Leonor Delgado; Luis Monteiro; Patrícia Silva; Hassan Bousbaa; Fernanda Garcez; Silva, João Pedro Nunes; Paula Brilhante-Simões; Isabel Pires; Justina Prada. "BUBR1 as a Prognostic Biomarker in Canine Oral Squamous Cell Carcinoma". Animals 12 22 (2022): 3082-3082. http://dx.doi.org/10.3390/ani12223082.
    10.3390/ani12223082
  10. Quendera, Ana P.; Seixas, André F.; dos Santos, Ricardo F.; Santos, Inês; Silva, João P. N.; Arraiano, Cecília M.; Andrade, José M.. "RNA-Binding Proteins Driving the Regulatory Activity of Small Non-coding RNAs in Bacteria". Frontiers in Molecular Biosciences 7 (2020): http://dx.doi.org/10.3389/fmolb.2020.00078.
    Open access • Published • 10.3389/fmolb.2020.00078
  11. Silva, João P. N.; Lopes, Soraia Vidigal; Grilo, Diogo J.; Hensel, Zach. "Plasmids for Independently Tunable, Low-Noise Expression of Two Genes". mSphere 4 3 (2019): http://dx.doi.org/10.1128/msphere.00340-19.
    Open access • Published • 10.1128/msphere.00340-19

Other

Other output
  1. Antimitóticos de segunda geração (SGAs) em foco: uma segunda oportunidade para aumentar sua eficácia no tratamento do câncer de pulmão. Research proposal submitted to CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil, for funding. Unfortunately the proposal got rejected. ID:443778/2023-0. 2023. Silva, João Pedro Nunes; Pinto, Bárbara; Bousbaa, Hassan; Silva, Patrícia M. A.; Juliana Carvalho-Tavares.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/06/02 Promoting oral cancer cell death by combining an apoptosis inducer with an antimitotic II International Congress of UNIPRO
Oral Pathology and Rehabilitation Research Unit (Penafiel, Portugal)
2022/10/27 The combination of Navitoclax with second-generation antimitotics potentiates therapeutic effects in oral cancer cells PhD Day 2022
Instituto Universitário de Ciências da Saúde - Gandra (Portugal) (Gandra, Portugal)
2021/10/15 The Second-generation of antimitotics: mechanistic insights into the anticancer activity and therapeutic potential PhD Day 2021
Instituto Universitário de Ciências da Saúde - Gandra (Portugal) (Portugal)
2021/10/08 Os inibidores de divisão celular de segunda geração no cancro oral: modelo 2D vs 3D Comunicar a ciência
Instituto Universitário de Ciências da Saúde - Gandra (Portugal) (Gandra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - 2024/09/18 Exploring mitotic proteins KSP and Aurora B as potential biomarkers and treatment targets for oral cancer
Co-supervisor
 Ciências Biomédicas (Other)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2023 - 2024/07/25 Role of Curcumin and Paclitaxel in oral cancer - an in vitro study
Co-supervisor
 Medicina Dentária (Master)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/10/01 - 2021/10/01 Host (organizer and moderator) of the webinar seminar "tRNAs: translating the future of NSCLC research" by guest speaker PhD Mafalda Santos from i3S and IPATIMUP (2021/10/01 - 2021/10/01)
Seminar
 Instituto Universitário de Ciências da Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/05/02 - 2024/05/03 Participation in the 3rd TOXRUN International Congress 2024 with the poster "KSP and Aurora B as potential biomarkers and therapeutic targets for head and neck cancer"
Congress
 III TOXRUN International Congress 2024
Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2023/10/26 - 2023/10/26 Participation in the PhD day 2023 with the poster "Co-inhibition of mitotic kinesins and kinases with BCL-2 family inhibitors enhances cytotoxicity of oral cancer cells"
Meeting
 PhD Day 2023
Instituto Universitário de Ciências da Saúde, Portugal
2023/05/08 - 2023/05/08 Participation in the workshop "Análise de dados em biociências com ferramentas open source uma abordagem prática"
Workshop
 Análise de dados em biociências com ferramentas open source uma abordagem prática
Instituto Universitário de Ciências da Saúde, Portugal
2023/05/02 - 2023/05/04 Participation in the 7th International Symposium on Immunobiologicals
Congress
Instituto de Tecnologia em Imunobiológicos, Brazil

Fundação Oswaldo Cruz, Brazil
2023/04/26 - 2023/04/27 Participation in the 2nd TOXRUN International Congress 2023 with the poster "Co-inhibition of mitotic kinesins and kinases with BCL-2 family inhibitors enhances cytotoxicity of oral cancer cells"
Congress
 II TOXRUN International Congress 2023
Instituto Universitário de Ciências da Saúde, Portugal
2022/10/27 - 2022/10/27 Participation in the PhD day 2022 with the poster "The combination of Navitoclax with second-generation antimitotics potentiates therapeutic effects in oral cancer cells"
Meeting
 PhD Day 2022
Instituto Universitário de Ciências da Saúde, Portugal
2022/09/24 - 2022/09/24 Participation in the 4th ENJIO with the poster "Potenciando o efeito terapêutico do inibidor da KSP numa combinação com Navitoclax em células de cancro oral"
Congress
 4º Encontro de Jovens Investigadores em Oncologia
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2022/07/26 - 2022/07/26 1 º EnantioTox Workshop Series
Workshop
 1 º EnantioTox Workshop Series
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2022/04/07 - 2022/04/08 Participation in the 1st Congresso Internacional da TOXRUN with the poster "Improving the antitumoral activity of the second-generation antimitotics"
Congress
 I Congresso Internacional da TOXRUN
Instituto Universitário de Ciências da Saúde, Portugal
2022/03/13 - 2022/03/16 Attedance of EMBL Conference: From 3D light to 3D electron microscopy
Conference
 EMBL Conference: From 3D light to 3D electron microscopy
European Molecular Biology Laboratory, Germany
2021/11/25 - 2021/11/27 Participation in the 4.ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia
Congress
 4.ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia
Rede Académica das Ciências da Saúde da Lusofonia, Angola
2019/12/05 - 2019/12/07 Participation in the congress Microbiotec with the poster "Elusive roles of an RNA chaperone in the membrane damage stress response"
Congress
 Microbiotec 2019
Universidade de Coimbra, Portugal
2017/03/27 - 2017/03/28 Participation in the congress EU Cost Action FA1306 - The quest for tolerant varieties: phenotyping at plant and cellular level 2017 with to posters: "Are chlorophyll fluorescence and machine learning techniques able to automatically classify Arabidopsis water stress status" and "Using the chlorophyll fluorescence signal and machine learning techniques to automatically identify Quercus species: preliminary results"
Congress
 EU Cost Action FA1306 - The quest for tolerant varieties: phenotyping at plant and cellular level 2017
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020/10 - 2021/01 English classes in the scope of "Atividades de Enriquecimento Curricular" to children aged 6-7 (Menos de 4 anos de escolaridade) Escola Básica Paulino Montez, Portugal
Distinctions

Award

2023 Honorable Mention
Instituto Universitário de Ciências da Saúde, Portugal