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A. Valente has a PhD in Chemistry from the Université Lille I-Sciences et Technologie, France (2010), whereby she acquired experience in polymerization catalysis and organometallic synthesis (lanthanides and ruthenium). She joined FCUL in 2010 where she did 2 postdocs in distinct areas of organometallic chemistry (non-linear optics and biomedical). In 2014, after a very competitive call, AV started an FCT Investigator position and independent research at CQE-FCUL where she developed polymer-metal conjugates for targeted cancer therapy. She merged her know-how in organometallic chemistry with her expertise in polymers to create this innovative family of compounds. The important results led AV`s team to patent this work (WO2016/087932) that has secured private investment and led to the creation of a spin-off (Something in Hands - Investigação Científica, Lda; rebranded as R-nuucell). R-nuucell has been a semi-finalist in the very competitive EIT Health InnoStars Awards 2021 and of EIT Health Catapult 2023-24 and has been one of the awardees of the Women TechEU (European Innovation Council). In 2019 AV won a contract in the frame of the CEEC Individual 2017 confirming the potential of her scientific path and research. During the last years, she expanded her panel of expertise, while at Rutgers University, USA, under the scope of a Fulbright Grant, in cell proliferation and viability assays, flow cytometry, and speciation and metal quantification by ICP-MS. So, AV path is marked by a thematic mobility and competences synergy allowing her to gain an extensive and wide-ranging experience in several key areas for the successful development of new anticancer drugs. She has so far 54 papers in international peer review journals (27 as senior corresponding author), 6 book chapters, and several conference proceedings, and was (co)author of ~75 talks in national and international conferences and seminars in post-graduate courses. AV was the Principal Investigator of two research projects funded by the Portuguese Foundation for Science and Technology (FCT), of a Royal Society of Chemistry (RSC) project and was coordinator of the project CanceRusolution from Women TechEU. Presently, AV is the PI of an Innovation project awarded by FCUL and FCiências.ID. AV also participated in two COST actions and in two Transnational Cooperation Programmes and is currently team member of the COST action EURESTOP (CA21145). AV was also responsible for the scientific supervision and initiation to research of several students (15 grad. projects; 13 international projects (Erasmus or STSM), 16 MSc + 6 PhD thesis + 2post-doc).
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Identification

Personal identification

Full name
Andreia Marques Valente

Citation names

  • Valente, Andreia

Author identifiers

Ciência ID
9F1B-8F8A-EBE6
ORCID iD
0000-0002-3370-208X
Google Scholar ID
https://scholar.google.pt/citations?hl=en&user=F19hQbYAAAAJ
Researcher Id
D-9251-2011
Scopus Author Id
23570219600

Addresses

  • Faculdade de Ciências da Universidade de Lisboa, DQB, Ed. C8,, Campo Grande, 1749-016, Lisboa, Lisboa, Portugal (Professional)

Websites

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2010
Concluded
 Molécules et Matières Condensée (Docteur)
Université des Sciences et Tecnhologie de Lille 1, France
"Lanthanide based coordinative chain transfer polymerization for architecture control in (co)polymers and ruthenium catalyzed ring-opening polymerization: two aspects of atom economy in polymerization catalysis" (THESIS/DISSERTATION)
 Très Honorable
2007
Concluded
 Química Inorgânica Biomédica - Aplicações em Diagnóstico e Terapia (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Síntese de metalocenos de ruténio e avaliação das suas potencialidades antitumorais" (THESIS/DISSERTATION)
 Muito Bom (19 Valores)
2006
Concluded
 Licenciatura em Química Tecnológica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Controlled, “living” and syndioselective styrene polymerization using rare earth borohydrides associated with dialkylmagnesium compounds" (THESIS/DISSERTATION)
 15 valores
Affiliation

Science

Category
Host institution 		Employer
2019/05/01 - Current Auxiliary Researcher (Research) Faculdade de Ciências, Universidade de Lisboa, Portugal
2014/01/01 - 2018/12/31 Auxiliary Researcher (Research) Universidade de Lisboa Faculdade de Ciências, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2013 - Current Assistant Professor (University Teacher) Universidade de Lisboa, Portugal

Positions / Appointments

Category
Host institution 		Employer
2020 - Current Member of the Executive Commission of Centro de Química Estrutural Faculdade de Ciências, Universidade de Lisboa, Portugal
Universidade de Lisboa Centro de Química Estrutural, Portugal
2020/07 - 2023/07 Co-Coordinator of the Technological Chemistry Master (Mestrado em Química Tecnológica) Faculdade de Ciências, Universidade de Lisboa, Portugal
Faculdade de Ciências, Universidade de Lisboa, Portugal
2020/07 - 2023/07 Member of the Scientific Committee of the Technological Chemistry Master (Mestrado em Química Tecnológica) Faculdade de Ciências, Universidade de Lisboa, Portugal

Others

Category
Host institution 		Employer
2021/02 - Current Co-founder of the spin-off ´Something in Hands - Investigação Científica, Lda` (rebranded as R-nuucell) Faculdade de Ciências, Universidade de Lisboa, Portugal
2017 - Current Co-founder of HATICancer Proto-Company Faculdade de Ciências, Universidade de Lisboa, Portugal
2015/11/01 - Current Evaluator for the Fulbright Program in Portugal Universidade de Lisboa Faculdade de Ciências, Portugal
2015/01/07 - 2015/04/07 Visiting researcher at Rutgers University, USA: Speciation of ruthenium metallodrugs by ion chromatography coupled to an ICPMS. Rutgers The State University of New Jersey, United States
2014/06/01 - 2014/07/31 Visiting researcher at Rutgers University, USA: Speciation of ruthenium metallodrugs by ion chromatography coupled to an ICPMS. Rutgers The State University of New Jersey, United States
2012/04/15 - 2013/12/31 Post-Doctoral Fellow, with Fundação para a Ciência e Tecnologia (FCT) grant: SFRH/BPD/80459/2011 - Polymeric Metal Complexes: New antitumoral agents with applications in controlled drug delivery Universidade de Lisboa Faculdade de Ciências, Portugal
2011/12/01 - 2012/04/14 Post-Doctoral Fellow (Grant under the PTDC-QUI-66148-2006 Project - Synthesis of new compounds with non linear optics activity ) Universidade de Lisboa Faculdade de Ciências, Portugal
2007/10/01 - 2010/10/15 PhD student in the area of polymerization catalysis: new lanthanide and ruthenium catalysts synthesis to the polymerization of (a)polar monomers. New concepts in catalysis and new materials architectu École nationale supérieure de chimie de Lille, France
2006/09/01 - 2007/09/30 Research in the frame of the M.Sc. thesis in Medicinal Inorganic Chemistry Universidade de Lisboa Faculdade de Ciências, Portugal
2006/02/01 - 2006/08/31 Erasmus training period in the frame of the Technologic Chemistry Graduation, in the area of polymerization catalysis. École nationale supérieure de chimie de Lille, France
Projects

Grant

Designation Funders
2023 - Current Multifunctional Ruthenium and Selenium Drugs to Overcome Multidrug Resistance in Cancer
UI/BD/154408/2023
Supervisor
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/06/01 - Current FCT NKFIH 2019/2020 - Development and biospeciation studies of antitumor ruthenium complexes
FCT/NKFIH_2019/2020
Ongoing
2019 - Current New ruthenium-based anticancer agents: promising therapeutic approach towards colorectal cancer
SFRH/BD/139271/2018
Supervisor
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019 - Current Development of novel iron-cyclopentadienyl compounds for cancer therapy
SFRH/BD/ 139412/2018
Supervisor
Faculdade de Ciências, Universidade de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019 - Current Targeting cancer with ruthenium compounds
SFRH/BD/135830/2018
Supervisor
Faculdade de Ciências, Universidade de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2024/03/01 - 2026/02/28 Targeting Mutated KRAS
na
Principal investigator
Faculdade de Ciências, Universidade de Lisboa, Portugal
 Faculdade de Ciências, Universidade de Lisboa

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências
Ongoing
2015 - 2019 Polymer-metal based compounds to target (non)hormone-responsive cancers: synthesis and mechanistic evaluation
SFRH/BD/ 100515/2014
Supervisor
Faculdade de Ciências, Universidade de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2015/01 - 2015/04 On the Mode of Action of Cyclopentadienyl Ruthenium (Macro)Metallodrugs
9f77cbc2fbfd900949a87718e3711f92
Principal investigator
Council for International Exchange of Scholars
Concluded
2012 - 2013 Polymeric Metal Complexes: New antitumoral agents with applications in controlled drug delivery
SFRH/BPD/80459/2011
Post-doc Fellow
Centro de Ciências Moleculares e Materiais - Faculdade de Ciências, Universidade de Lisboa, Portugal
Concluded
2010 - 2012 Pos-Doc within the project “Synthesis of new compounds with non-linear optic activity” (PTDC-QUI-66148-2006)
PTDC-QUI-66148-2006
Post-doc Fellow
Centro de Ciências Moleculares e Materiais - Faculdade de Ciências, Universidade de Lisboa, Portugal

Contract

Designation Funders
2019 - Current Polymer-metal conjugates: wide-ranging anticancer agents
CEECIND/01974/2017
Principal investigator
Faculdade de Ciências, Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Instituto de Ciências Moleculares
LA/P/0056/2020
10.54499/LA/P/0056/2020
Universidade de Coimbra Centro de Investigação em Antropologia e Saúde, Portugal

Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Centro de Investigação em Química, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Coimbra, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/06 - 2023/05 EIC Women TechEU - project CanceRusolution (101071749)
101071749
Principal investigator
R-nuucell, Portugal
 European Innovation Council
Ongoing
2018/09 - 2022/04/30 Fighting metastatic cancers: prime time for ruthenium
PTDC/QUI-QIN/28662/2017
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2019 - 2022 Transnational Cooperation Programme - Portugal-Hungary, ´Development and biospeciation studies of antitumor ruthenium complexes`
FCT/NKFIH 2019/2020
Researcher
Faculdade de Ciências, Universidade de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2022 New diagnostic and therapeutic tools against multidrug resistant tumors - STRATAGEM (CA17104)
CA17104
Researcher
Horizon 2020 Framework Programme
Concluded
2019/01/01 - 2019/12/31 Centro de Química Estrutural
UID/QUI/00100/2019
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/11 - 2019/11 Polymer-Ruthenium Complexes for targeted drug delivery: a new approach to fight cancer
Provided by PTCRIS: 147600
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
2014 - 2018 Smart Inorganic Polymers (SIPs; CM1302)
CM1302
Researcher
Horizon 2020 Framework Programme
Concluded
2016 - 2016 RSC Research Fund Grant, ´Multifunctional polymer-metal complexes: an innovative approach to treat cancer`
na
Principal investigator
Royal Society of Chemistry
Concluded
2015 - 2016 Complexes of Flavonoid`s Schiff bases: Impact of structural modification on the chelating ability and evaluation of biological and therapeutic properties
FCT RD0480
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2012/03/01 - 2015/08/31 Avaliação pré-clínica de potenciais fármacos de Ruténio na terapia do cancro
PTDC/QUI-QUI/118077/2010
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/03 - 2015/08 Preclinical evaluation of ruthenium potential drugs for cancer therapy
Provided by PTCRIS: 118077
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Projecto Estratégico - UI 536 - 2011-2012
PEst-OE/QUI/UI0536/2011
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Complexos de Ruténio para aplicação anti-tumoral
PTDC/QUI-QUI/101187/2008
Universidade de Lisboa Instituto Superior Técnico, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01 - 2013/06 Ruthenium complexes for anti-tumour application
Provided by PTCRIS: 101187
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2012 Synthesis of Organometallic Molecular and Polymeric Materials with Nonlinear Optical Properties
PTDC/QUI/66148/2006
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2023 - Current Semi-finalists of Catapult 2023-24
2023-EHC-2592
Co-founder of the winning company, R-nuucell
R-nuucell, Portugal
Ongoing
2022 - Current COST action “European Network for diagnosis and treatment of antibiotic-resistant bacterial infections” – EURESTOP (CA21145)
CA21145
Researcher
Ongoing
2021 - 2021 Innostars Awards Semifinalists
n/a
Co-founder of the winning company, R-nuucell
R-nuucell, Portugal
 European Institute of Innovation & Technology
Concluded
2019 - 2021 Label-free protein quantification of cancer cells treated with new ruthenium metallodrugs
EPIC-XS-0000045
Principal investigator
Universidade de Lisboa Centro de Química Estrutural, Portugal
Concluded
Outputs

Publications

Book
  1. Silva, T.J.L.; Mendes, P.J.; Morais, T.S.; Valente, A.; Robalo, M.P.; Garcia, M.H.. "RuCp" a versatile moiety: From NLO to antitumor properties. 2014.
Book chapter
  1. Valente, Andreia; Morais, Tânia S.; Teixeira, Ricardo Jorge Gonçalves; Matos, Cristina P.; Tomaz, Ana Isabel; Garcia, Maria Helena. "Ruthenium and iron metallodrugs: new inorganic and organometallic complexes as prospective anticancer agents". In Chp 7. In Synthetic Inorganic Chemistry. Elsevier, Editor: Ewan Hamilton, 2021.
    Published
  2. Valente, Andreia; Morais, Tânia S.; Ricardo G. Teixeira; Cristina P. Matos; Garcia, M. Helena; Tomaz, Ana Isabel;. Corresponding author: Tomaz, Ana Isabel;. "Chapter 6 - New Inorganic Therapeutics I : : Ruthenium and iron metallodrugs: new inorganic and organometallic complexes as prospective anticancer agents". In Synthetic Inorganic Chemistry - New perspectives, edited by Ewan J. M. Hamilton. Elsevier, 2021.
    Published
  3. Valente, Andreia; Precker, Rafaella L. M.; Hey-Hawkins, Evamarie. Corresponding author: Valente, Andreia. "Inorganic Polymers for Potential Medicinal Applications". In Smart Inorganic Polymers, 243-276. Wiley-VCH Verlag GmbH & Co. KGaA, 2019.
    10.1002/9783527819140.ch9
  4. Valente, Andreia; Tiago J. L. Silva; Paulo J. G. Mendes; Ana Isabel Tomaz; M. Helena Garcia. Corresponding author: Valente, Andreia. "Chapter 16.5 - Polymerization of e-Caprolactone Using a Ruthenium(II) Mixed Metallocene Catalyst". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (COCELC). Royal Society of Chemistry, 2017.
  5. Matos, António; Mendes, Filipa; Valente, Andreia; Morais, Tânia; Tomaz, Ana Isabel; Zinck, Philippe; Garcia, Maria Helena; Bicho, Manuel; Marques, Fernanda. "Ruthenium-Based Anticancer Compounds: Insights into Their Cellular Targeting and Mechanism of Action". In Ruthenium Complexes – Photochemical and Biomedical Applications, 201-219. Wiley-VCH Verlag GmbH & Co. KGaA, 2017.
    10.1002/9783527695225.ch10
  6. Valente, A.; Silva, Tiago J.L.; Mendes, Paulo J. G.; Tomaz, Ana Isabel; Garcia, M. Helena; Mendes, Paulo J.; Silva, Tiago JL; Valente, Andreia. "Polymerization of e-Caprolactone Using a Ruthenium(II) Mixed Metallocene Catalyst". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (Chp. 16.5), edited by Afonso, Carlos A M; Candeias, Nuno R; Simão, Dulce Pereira; Trindade, Alexandre F; Coelho, Jaime A S; Tan, Bin; Franzen, Robert, 864-867. Cambridge, United Kingdom: Royal Society of Chemistry, 2017.
    Published
  7. Tiago J. L. Silva; Paulo J. Mendes; Tânia S. Morais; Valente, Andreia; M. Paula Robalo; M. Helena Garcia. "''RuCp'' a Versatile Moiety: From NLO to Antitumor Properties". In RUTHENIUM: SYNTHESIS, PHYSICOCHEMICAL PROPERTIES AND APPLICATIONS. Nova Science Publishers, 2014.
  8. Valente, Andreia; Zinck, Philippe. Corresponding author: Valente, Andreia. "Polymer-Metal Complexes (PMC) for Cancer Therapy". In Recent Research Developments in Polymer Science. Transworld Research Network, Trivandrum, India, 2012.
Conference abstract
  1. Preto, Ana; Brás, Ana Rita; Fernandes, Pedro; Moreira, Tiago; Valente, Andreia. "New ruthenium-cyclopentadienyl agents as a new strategy to fight colorectal cancer". 2021.
    10.3390/ecmc2021-11457
Conference paper
  1. Matos, António; Marques, Fernanda; Francisco, Rita; Moreira, Tiago; Preto, Ana; Garcia, M. Helena; Valente, Andreia. "Unraveling the mode of action of new promising polymer–ruthenium conjugates". 2016.
    10.1080/01913123.2016.1272669
Conference poster
  1. Guerreiro, Ana; Valente, Andreia; Brito, Pedro. Corresponding author: Brito, Pedro. "Stability of the Macrocyclic Gd-DOTA Contrast Agent (DOTAREM) Under Different Estuarine Environmental Conditions". Paper presented in Setac Europe 33rd Annual Meeting, 2023.
  2. Ricardo G. Teixeira; Belisario, Dimas C.; Oliveira, Nuno F. B.; Sequeira, João G. N.; Romero, Isabel; Riganti, Chiara; Machuqueiro, Miguel; et al. Corresponding author: Valente, Andreia. "Targeting P-gp with Ru-cyclopentadienyl compounds: an approach to overcome cancer multidrug resistance". Paper presented in CQE Days, 2022.
  3. Fernandes, Pedro; Rita Brás, Ana; Moreira, Tiago; Valente, Andreia; Preto, Ana. "Ruthenium-based agents as promising metallodrugs to fight colorectal cancer". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020.
  4. Brás, Ana Rita; Fernandes, Pedro; Moreira, Tiago; Valente, Andreia; Preto, Ana. "Fighting colorectal cancer with ruthenium-based agents". Paper presented in CQE days, 2020.
  5. Brás, Ana R.; Fernandes, Pedro; Moreira, Tiago; Valente, Andreia; Preto, Ana. "New ruthenium-based agents target actin cytoskeleton in colorectal cancer cells". Paper presented in AACR-EACR-ASPIC Conference: Tumor Microenvironment, 2020.
  6. Brás, Ana R.; Fernandes, Pedro; Moreira, Tiago; Valente, Andreia; Ana Preto. "New ruthenium-based anticancer agents: uncovering the molecular targets towards colorectal cancer therapy". Paper presented in 6th Annual Meeting of International Society of Cancer Metabolism, 2019.
  7. Fernandes, Pedro; Brás, Ana R.; Moreira, Tiago; Valente, Andreia; Ana Preto. "New ruthenium-biotinylated anticancer agents for colorectal cancer therapy". Paper presented in V Symposium of the Doctoral Program on Molecular and Environmental Biology, 2019.
  8. Fernandes, Pedro; Brás, Ana Rita; Valente, Andreia; Preto, Ana. "New ruthenium-biotinylated anticancer agent for colorectal cancer therapy". Paper presented in V Symposium of the Doctoral Program on Molecular and Environmental Biology, 2019.
  9. Brás, Ana R.; Fernandes, Pedro; Moreira, Tiago; Valente, Andreia; Preto, Ana. "Discovering the molecular targets of new ruthenium-based anticancer agents for colorectal cancer therapy". Paper presented in 26th Porto Cancer Meeting, 2019.
  10. Brás, Ana Rita; Moreira, Tiago; Silva, Soraia; Garcia, M. Helena; Valente, Andreia; Preto, Ana. "Multifunctional polymer-ruthenium conjugates: promising therapeutic approach to colorectal cancer". Paper presented in IV Symposium of the Doctoral Program on Molecular and Environmental Biology, 2018.
  11. Brás, Ana Rita; Moreira, Tiago; Silva, Soraia; Garcia, M. Helena; Valente, Andreia; Preto, Ana. "Unraveling the molecular targets of new ruthenium compounds towards colorectal cancer therapy". Paper presented in 3rd ASPIC International Congress, 2018.
  12. Brás, Ana Rita; Moreira, Tiago; Silva, Soraia; Garcia, M. Helena; Valente, Andreia; Preto, Ana. "New ruthenium-based anticancer agents: a promising therapeutic approach to colorectal cancer". Paper presented in 25th Porto Cancer Meeting, 2018.
  13. Valente, Andreia; Moreira, Tiago; Brás, Ana Rita; Preto, Ana; Garcia, M. Helena. "Cancer targeted therapy: the next generation of metallodrugs". Paper presented in ICBIC18 ¿ International Conference on Biological Inorganic Chemistry, 2017.
  14. Mendes, Paulo J.G.; Zinck, Philippe; Valente, Andreia; Visseaux, Marc; Silva, Tiago J. L.; Garcia, M. Helena. "Dois aspectos para uma economia de catalisador de polimerizações por transferência de cadeia". Paper presented in Encontro Ciência QB, 2011.
Journal article
  1. Podolski-Renic, Ana; Cipak Gašparovic, Ana; Valente, Andreia; Lopez, Oscar; Bormio Nunes, Julia H.; Kowol, Christian R.; Heffeter, Petra; Filipovic, Nenad R.. Corresponding author: Filipovic, Nenad R.. "Schiff bases and their metal complexes to target and overcome (multidrug) resistance in cancer". European Journal of Medicinal Chemistry (2024): 116363. http://dx.doi.org/10.1016/j.ejmech.2024.116363.
    10.1016/j.ejmech.2024.116363
  2. Teixeira, Ricardo G.; Stefanelli, Alessia; Pilon, Adhan; Warmers, Rebecca; Fontrodona, Xavier; Romero, Isabel; Costa, Paulo J.; et al. Corresponding author: Valente, Andreia. "Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands". Journal of Medicinal Chemistry (2024): http://dx.doi.org/10.1021/acs.jmedchem.3c01036.
    10.1021/acs.jmedchem.3c01036
  3. Maximiano, Inês; Henriques, Catarina; Teixeira, Ricardo G.; Marques, Fernanda; Valente, Andreia; Antunes, Alexandra M.M.. Corresponding author: Valente, Andreia. "Lead to hit ruthenium-cyclopentadienyl anticancer compounds: Cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling". Journal of Inorganic Biochemistry 251 (2024): 112436. http://dx.doi.org/10.1016/j.jinorgbio.2023.112436.
    10.1016/j.jinorgbio.2023.112436
  4. Pilon, Adhan; Avecilla, Fernando; Rácz, Bálint; Gátszegi, Gerda T.; Spengler, Gabriella; Robalo, M. Paula; Enyedy, Éva A.; Garcia, M. Helena; Valente, Andreia. Corresponding author: Valente, Andreia. "Iron(II)-cyclopentadienyl compounds are cytotoxic against colon adenocarcinoma cell lines: Ethylenebis(diphenylphosphane) vs. triphenylphosphane". Journal of Inorganic Biochemistry 249 (2023): 112386. http://dx.doi.org/10.1016/j.jinorgbio.2023.112386.
    10.1016/j.jinorgbio.2023.112386
  5. Teixeira, Ricardo G.; Mészáros, János P.; Matos, Beatriz; Côrte-Real, Leonor; Xavier, Cristina P.R.; Fontrodona, Xavier; Garcia, M. Helena; et al. Corresponding author: Valente, Andreia. "Novel family of [RuCp(N,N)(P)]+ compounds with simultaneous anticancer and antibacterial activity: Biological evaluation and solution chemistry studies". European Journal of Medicinal Chemistry 262 (2023): 115922. http://dx.doi.org/10.1016/j.ejmech.2023.115922.
    10.1016/j.ejmech.2023.115922
  6. Andres Alguacil; Franco Scalambra; Antonio Romerosa; Andreia Bento-Oliveira; Fernanda Marques; Ines Maximiano; Rodrigo F. M. de Almeida; et al. "Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives". Bioinorganic Chemistry and Applications (2023): https://doi.org/10.1155/2023/6669394.
    10.1155/2023/6669394
  7. Teixeira, Ricardo G.; Salaroglio, Iris C.; Oliveira, Nuno F. B.; Sequeira, João G. N.; Fontrodona, Xavier; Romero, Isabel; Machuqueiro, Miguel; et al. Corresponding author: Valente, Andreia. "Fighting Multidrug Resistance with Ruthenium–Cyclopentadienyl Compounds: Unveiling the Mechanism of P-gp Inhibition". Journal of Medicinal Chemistry 66 20 (2023): 14080-14094. http://dx.doi.org/10.1021/acs.jmedchem.3c01120.
    10.1021/acs.jmedchem.3c01120
  8. Brás, Ana Rita; Fernandes, Pedro; Moreira, Tiago; Morales-Sanfrutos, Julia; Sabidó, Eduard; Antunes, Alexandra M. M.; Valente, Andreia; Preto, Ana. Corresponding author: Valente, Andreia. "New Ruthenium-Cyclopentadienyl Complexes Affect Colorectal Cancer Hallmarks Showing High Therapeutic Potential". Pharmaceutics 15 6 (2023): 1731. http://dx.doi.org/10.3390/pharmaceutics15061731.
    10.3390/pharmaceutics15061731
  9. Pilon, Adhan; Avecilla, Fernando; Mohai, Miklós; Enyedy, Éva A.; Rácz, Bálint; Spengler, Gabriella; Garcia, M. Helena; Valente, Andreia. Corresponding author: Valente, Andreia. "First iron(II) organometallic compound acting as ABCB1 inhibitor". European Journal of Medicinal Chemistry (2023): 115466. http://dx.doi.org/10.1016/j.ejmech.2023.115466.
    10.1016/j.ejmech.2023.115466
  10. Stefanelli, Alessia; Teixeira, Ricardo G.; Pilon, Adhan; Warmers, Rebecca; Ott, Ingo; Kowol, Christian R.; Brozovic, Anamaria; et al. "Anticancer activity and paraptosis induction of novel bipyridine-silver(I) compounds against resistant colorectal and ovarian cancer cell lines". Cancer Research (2023): https://publons.com/wos-op/publon/62927111/.
    10.1158/1538-7445.AM2023-4905
  11. Catarina Teixeira-Guedes; Ana Rita Brás; Ricardo G. Teixeira; Valente, Andreia; Ana Preto. Corresponding author: Valente, Andreia. "Ruthenium(II)-Cyclopentadienyl-Derived Complexes as New Emerging Anti-Colorectal Cancer Drugs". Pharmaceutics 14 6 (2022): 1293-1293. https://doi.org/10.3390/pharmaceutics14061293.
    10.3390/pharmaceutics14061293
  12. Leonor Côrte-Real; Ana Rita Pinto Brás; Adhan Pilon; Nuno Mendes; Ana Sofia Ribeiro; Tiago D. Martins; José Paulo S. Farinha; et al. "Biotinylated Polymer-Ruthenium Conjugates: In Vitro and In Vivo Studies in a Triple-Negative Breast Cancer Model". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/7/1388.
    10.3390/pharmaceutics14071388
  13. Julie Meimoun; Yupin Phuphuak; Remi Miyamachi; Yong Miao; Marc Bria; Cyril Rousseau; Guilherme Nogueira; et al. "Cyclodextrins Initiated Ring-Opening Polymerization of Lactide Using 4-Dimethylaminopyridine (DMAP) as Catalyst: Study of DMAP/ß-CD Inclusion Complex and Access to New Structures". Molecules 27 3 (2022): 1083-1083. https://doi.org/10.3390/molecules27031083.
    10.3390/molecules27031083
  14. Andreia Valente; Ana Podolski-Renic; Isabella Poetsch; Nenad Filipovic; Óscar López; Iztok Turel; Petra Heffeter. "Metal- and metalloid-based compounds to target and reverse cancer multidrug resistance". Drug Resistance Updates 58 (2021): 100778-100778. https://doi.org/10.1016/j.drup.2021.100778.
    10.1016/j.drup.2021.100778
  15. Karas, Brittany F; Hotz, Jordan M; Gural, Brian M; Terez, Kristin R; DiBona, Victoria L; Côrte-Real, Leonor; Valente, Andreia; Buckley, Brian T; Cooper, Keith R. "Anticancer Activity and In Vitro to In Vivo Mechanistic Recapitulation of Novel Ruthenium-Based Metallodrugs in the Zebrafish Model". Toxicological Sciences 182 1 (2021): 29-43. http://dx.doi.org/10.1093/toxsci/kfab041.
    10.1093/toxsci/kfab041
  16. Ricardo G. Teixeira; Dimas C. Belisario; Xavier Fontrodona; Isabel Romero; Ana Isabel Tomaz; M. Helena Garcia; Chiara Riganti; Valente, Andreia. Corresponding author: Valente, Andreia. "Unprecedented collateral sensitivity for cisplatin-resistant lung cancer cells presented by new ruthenium organometallic compounds". Inorganic Chemistry Frontiers 8 (2021): 1983-1996. https://doi.org/10.1039/D0QI01344G.
    Published • 10.1039/D0QI01344G
  17. Nazanin Kordestani; Hadi Amiri Rudbari; Isabel Correia; Valente, Andreia; Leonor Côrte-Real; Mohammad Khairul Islam; Nicola Micale; et al. Corresponding author: Valente, Andreia. "Heteroleptic enantiopure Pd(ii)-complexes derived from halogen-substituted Schiff bases and 2-picolylamine: synthesis, experimental and computational characterization and investigation of the influence of chirality and halogen atoms on the anticancer activity". New Journal of Chemistry 45 9 (2021): 9163-9180. https://doi.org/10.1039/D1NJ01491A.
    10.1039/D1NJ01491A
  18. Amiri Rudbari, Hadi; Kordestani, Nazanin; Correia, Isabel; Valente, Andreia; Côrte-Real, Leonor; Islam, Mohammad Khairul; Micale, Nicola; et al. "Heteroleptic enantiopure Pd(II)-complexes derived from halogen-substituted Schiff bases and 2-picolylamine: synthesis, experimental and computational characterization and investigation of the in¿uence of chirality and halogen atoms on the anticancer activity". New Journal of Chemistry (2021): http://dx.doi.org/10.1039/d1nj01491a.
    Published • 10.1039/d1nj01491a
  19. Pilon, Adhan; Brás, Ana Rita; Côrte-Real, Leonor; Avecilla, Fernando; Costa, Paulo J.; Preto, Ana; Garcia, M. Helena; Valente, Andreia. Corresponding author: Valente, Andreia. "A New Family of Iron(II)-Cyclopentadienyl Compounds Shows Strong Activity against Colorectal and Triple Negative Breast Cancer Cells". Molecules 25 7 (2020): 1592. http://dx.doi.org/10.3390/molecules25071592.
    10.3390/molecules25071592
  20. Askari, Banafshe; Rudbari, Hadi Amiri; Valente, Andreia; Bruno, Giuseppe; Micale, Nicola; Shivalingegowda, Naveen; Krishnappagowda, Lokanath Neratur. Corresponding author: Valente, Andreia. "Synthesis, Characterization and Anticancer Studies of Rh(I), Rh(III), Pd(II) and Pt(II) Complexes Bearing A Dithiooxamide Ligand". ChemistrySelect 5 2 (2020): 810-817. http://dx.doi.org/10.1002/slct.201903939.
    10.1002/slct.201903939
  21. Ricardo G. Teixeira; Fernanda Marques; M. Paula Robalo; Xavier Fontrodona; M. Helena Garcia; Simonetta Geninatti Crich; Clara Viñas; Valente, Andreia. Corresponding author: Valente, Andreia. "Ruthenium carboranyl complexes with 2,2'-bipyridine derivatives for potential bimodal therapy application". RSC Advances 10 (2020): 16266-16276. https://doi.org/10.1039/D0RA01522A.
    10.1039/D0RA01522A
  22. Gano, Lurdes; Pinheiro, Teresa; Matos, António P.; Tortosa, Francisco; Jorge, Tiago F.; Gonçalves, Maria S.; Martins, Marta; et al. Corresponding author: Marques, Fernanda. "Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools". Anti-Cancer Agents in Medicinal Chemistry 19 10 (2019): 1262-1275. http://dx.doi.org/10.2174/1871520619666190318152726.
    10.2174/1871520619666190318152726
  23. Karas, Brittany F.; Côrte-Real, Leonor; Doherty, Cathleen L.; Valente, Andreia; Cooper, Keith R.; Buckley, Brian T.. "A novel screening method for transition metal-based anticancer compounds using zebrafish embryo-larval assay and inductively coupled plasma-mass spectrometry analysis". Journal of Applied Toxicology 39 8 (2019): 1173-1180. http://dx.doi.org/10.1002/jat.3802.
    10.1002/jat.3802
  24. Pilon, Adhan; Lorenzo, Julia; Rodriguez-Calado, Sergi; Adão, Pedro; Martins, Ana M.; Valente, Andreia; Alves, Luis G.. Corresponding author: Valente, Andreia. "New Cyclams and Their Copper(II) and Iron(III) Complexes: Synthesis and Potential Application as Anticancer Agents". ChemMedChem 14 7 (2019): 770-778. http://dx.doi.org/10.1002/cmdc.201800702.
    10.1002/cmdc.201800702
  25. Côrte-Real, L.; Karas, B.; Gírio, P.; Moreno, A.; Avecilla, F.; Marques, F.; Buckley, B.T.; et al. Corresponding author: Valente, Andreia. "Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand". European Journal of Medicinal Chemistry (2019): 853-863. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058617947&partnerID=MN8TOARS.
    10.1016/j.ejmech.2018.12.022
  26. Côrte-Real, L.; Karas, B.; Brás, A.R.; Pilon, A.; Avecilla, F.; Marques, F.; Preto, A.; et al. Corresponding author: Valente, Andreia. "Ruthenium-Cyclopentadienyl Bipyridine-Biotin Based Compounds: Synthesis and Biological Effect". Inorganic Chemistry (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068345812&partnerID=MN8TOARS.
    10.1021/acs.inorgchem.9b00735
  27. Moreira, T.; Francisco, R.; Comsa, E.; Duban-Deweer, S.; Labas, V.; Teixeira-Gomes, A.-P.; Combes-Soia, L.; et al. Corresponding author: Valente, Andreia. "Polymer ´ruthenium-cyclopentadienyl` conjugates - New emerging anti-cancer drugs". European Journal of Medicinal Chemistry (2019): 373-384. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062147079&partnerID=MN8TOARS.
    10.1016/j.ejmech.2019.02.061
  28. Côrte-Real, L.; Teixeira, R.G.; Gírio, P.; Comsa, E.; Moreno, A.; Nasr, R.; Baubichon-Cortay, H.; et al. Corresponding author: Valente, Andreia. "Methyl-cyclopentadienyl Ruthenium Compounds with 2,2'-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential". Inorganic Chemistry 57 8 (2018): 4629-4639. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045544510&partnerID=MN8TOARS.
    10.1021/acs.inorgchem.8b00358
  29. Teixeira, R.G.; Brás, A.R.; Côrte-Real, L.; Tatikonda, R.; Sanches, A.; Robalo, M.P.; Avecilla, F.; et al. Corresponding author: Valente, Andreia. "Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells". European Journal of Medicinal Chemistry 143 (2018): 503-514. http://www.scopus.com/inward/record.url?eid=2-s2.0-85036521878&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.11.059
  30. Vancompernolle, Tom; Valente, Andreia; Chenal, Thomas; Zinck, Philippe; Del Rosal, Iker; Maron, Laurent; Taoufik, Mostafa; Harder, Sjoerd; Gauvin, Régis M.. "Silica-Grafted Lanthanum Benzyl Species: Synthesis, Characterization, and Catalytic Applications". Organometallics 36 20 (2017): 3912-3920. http://dx.doi.org/10.1021/acs.organomet.7b00538.
    10.1021/acs.organomet.7b00538
  31. Mendes, Nuno; Tortosa, Francisco; Valente, Andreia; Marques, Fernanda; Matos, António; Morais, Tânia S.; Tomaz, Ana Isabel; Gärtner, Fátima; Garcia, M. Helena. "In Vivo Performance of a Ruthenium-cyclopentadienyl Compound in an Orthotopic Triple Negative Breast Cancer Model". Anti-Cancer Agents in Medicinal Chemistry 17 1 (2017): 126-136. http://dx.doi.org/10.2174/1871520616666160922165133.
    10.2174/1871520616666160922165133
  32. Pilon, A.; Gírio, P.; Nogueira, G.; Avecilla, F.; Adams, H.; Lorenzo, J.; Garcia, M.H.; Valente, Andreia. Corresponding author: Valente, Andreia. "New iron cyclopentadienyl complexes bearing different phosphane co-ligands: Structural factors vs. cytotoxicity". Journal of Organometallic Chemistry 852 (2017): 34-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030979386&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2017.10.004
  33. Garcia, Maria Helena; Valente, Andreia; Morais, Tania S.; Tomaz, Ana Isabel. "Ruthenium new drug: paving the way for cancer therapy". Journal of Biological Inorganic Chemistry (2017): https://publons.com/wos-op/publon/15344537/.
  34. Morais, Tânia S; Valente, Andreia; Tomaz, Ana Isabel; Marques, Fernanda; Garcia, Maria Helena. "Tracking antitumor metallodrugs: promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds". Future Medicinal Chemistry 8 5 (2016): 527-544. http://dx.doi.org/10.4155/fmc.16.7.
    10.4155/fmc.16.7
  35. Nogueira, Guilherme; Favrelle, Audrey; Bria, Marc; Prates Ramalho, João P.; Mendes, Paulo J.; Valente, Andreia; Zinck, Philippe. "Adenine as an organocatalyst for the ring-opening polymerization of lactide: scope, mechanism and access to adenine-functionalized polylactide". Reaction Chemistry & Engineering 1 5 (2016): 508-520. http://dx.doi.org/10.1039/c6re00061d.
    10.1039/c6re00061d
  36. Nogueira, G.; Dömötör, O.; Pilon, A.; Robalo, M.P.; Avecilla, F.; Garcia, M.H.; Enyedy, É.A.; Valente, Andreia. Corresponding author: Valente, Andreia. "¿6-(2-phenoxyethanol) ruthenium(II)-complexes of 2,2'-bipyridine and its derivatives: Solution speciation and kinetic behaviour". Journal of Organometallic Chemistry 820 (2016): 20-29. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982672493&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2016.07.017
  37. Côrte-Real, L.; Paula Robalo, M.; Marques, F.; Nogueira, G.; Avecilla, F.; Silva, T.J.L.; Santos, F.C.; et al. Corresponding author: Valente, Andreia. "The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds". Journal of Inorganic Biochemistry 150 (2015): 148-159. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948716556&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2015.06.015
  38. Corte-Real, Leonor; Robalo, M.P.; Marques, F.; Nogueira, G.; Tomaz, A. Isabel; Garcia, M. Helena; Valente, Andreia. "Influence of structural factors in the modulation of cytotoxic activity". Medicinal Chemistry 05 10 (2015): 96-96. http://dx.doi.org/10.4172/2161-0444.c1.016.
    Published • 10.4172/2161-0444.c1.016
  39. Valente, Andreia; Stoclet, Gregory; Bonnet, Fanny; Mortreux, André; Visseaux, Marc; Zinck, Philippe. "Isoprene-Styrene Chain Shuttling Copolymerization Mediated by a Lanthanide Half-Sandwich Complex and a Lanthanidocene: Straightforward Access to a New Type of Thermoplastic Elastomers". Angewandte Chemie International Edition 53 18 (2014): 4638-4641. http://dx.doi.org/10.1002/anie.201311057.
    10.1002/anie.201311057
  40. Valente, Andreia; Garcia, M.. Corresponding author: Valente, Andreia. "Syntheses of Macromolecular Ruthenium Compounds: A New Approach for the Search of Anticancer Drugs". Inorganics 2 1 (2014): 96-114. http://dx.doi.org/10.3390/inorganics2010096.
    10.3390/inorganics2010096
  41. Côrte-Real, Leonor; Mendes, Filipa; Coimbra, Joana; Morais, Tânia S.; Tomaz, Ana Isabel; Valente, Andreia; Garcia, M. Helena; et al. "Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes". JBIC Journal of Biological Inorganic Chemistry 19 6 (2014): 853-867. http://dx.doi.org/10.1007/s00775-014-1120-y.
    10.1007/s00775-014-1120-y
  42. Valente, Andreia; Santos, A.M.; Côrte-Real, L.; Robalo, M.P.; Moreno, V.; Font-Bardia, M.; Calvet, T.; Lorenzo, J.; Garcia, M.H.. "New iron(II) cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leukemia cancer cells". Journal of Organometallic Chemistry 756 (2014): 52-60. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894195747&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2014.01.027
  43. Valente, Andreia; Mortreux, André; Visseaux, Marc; Zinck, Philippe. "Coordinative Chain Transfer Polymerization". Chemical Reviews 113 5 (2013): 3836-3857. http://dx.doi.org/10.1021/cr300289z.
    10.1021/cr300289z
  44. Matos, C.P.; Valente, Andreia; Marques, F.; Adão, P.; Paula Robalo, M.; De Almeida, R.F.M.; Pessoa, J.C.; et al. "New polydentate Ru(III)-Salan complexes: Synthesis, characterization, anti-tumour activity and interaction with human serum proteins". Inorganica Chimica Acta 394 (2013): 616-626. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868218698&partnerID=MN8TOARS.
    10.1016/j.ica.2012.09.026
  45. Valente, Andreia; Garcia, M.H.; Marques, F.; Miao, Y.; Rousseau, C.; Zinck, P.. Corresponding author: Valente, Andreia. "First polymer "ruthenium-cyclopentadienyl" complex as potential anticancer agent". Journal of Inorganic Biochemistry 127 (2013): 79-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884576725&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2013.07.002
  46. Valente, Andreia; Royer, S.; Narendra, M.; Silva, T.J.L.; Mendes, P.J.G.; Robalo, M.P.; Abreu, M.; Heck, J.; Garcia, M.H.. "Synthesis of new Fe(II) and Ru(II) ¿ 5 -monocyclopentadienyl compounds showing significant second order NLO properties". Journal of Organometallic Chemistry 736 (2013): 42-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876167870&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2013.02.028
  47. Valente, Andreia; Zinck, Philippe; Mortreux, André; Visseaux, Marc; Mendes, Paulo J.G.; Silva, Tiago J.L.; Garcia, M. Helena. "Polymerization of ¿-caprolactone using ruthenium(II) mixed metallocene catalysts and isopropyl alcohol: Living character and mechanistic study". Journal of Molecular Catalysis A: Chemical 346 1-2 (2011): 102-110. http://dx.doi.org/10.1016/j.molcata.2011.06.015.
    10.1016/j.molcata.2011.06.015
  48. Valente, Andreia; Zinck, P.; Mortreux, A.; Bria, M.; Visseaux, M.. "Half-lanthanocene/dialkylmagnesium-mediated coordinative chain transfer copolymerization of styrene and hexene". Journal of Polymer Science, Part A: Polymer Chemistry 49 17 (2011): 3778-3782. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960878625&partnerID=MN8TOARS.
    10.1002/pola.24816
  49. Valente, Andreia; Zinck, P.; Mortreux, A.; Visseaux, M.. "Borohydrido rare earth based coordinative chain transfer copolymerization: A convenient tool for tuning the microstructure of isoprene/styrene copolymers". Journal of Polymer Science, Part A: Polymer Chemistry 49 7 (2011): 1615-1620. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952147062&partnerID=MN8TOARS.
    10.1002/pola.24585
  50. Moreno, V.; Font-Bardia, M.; Calvet, T.; Lorenzo, J.; Avilés, F.X.; Garcia, M.H.; Morais, T.S.; Valente, Andreia; Robalo, M.P.. "DNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexes containing heteroaromatic ligands". Journal of Inorganic Biochemistry 105 2 (2011): 241-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649615202&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2010.10.009
  51. Garcia, M.H.; Valente, Andreia; Florindo, P.; Morais, T.S.; Piedade, M.F.M.; Duarte, M.T.; Moreno, V.; Avilés, F.X.; Loreno, J.. "New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy". Inorganica Chimica Acta 363 14 (2010): 3765-3775. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957982339&partnerID=MN8TOARS.
    10.1016/j.ica.2010.05.034
  52. Zinck, P.; Valente, Andreia; Bonnet, F.; Violante, A.; Mortreux, A.; Visseaux, M.; Ilinca, S.; Duchateau, R.; Roussel, P.. "Reversible coordinative chain transfer polymerization of styrene by rare earth borohydrides, chlorides/dialkylmagnesium systems". Journal of Polymer Science, Part A: Polymer Chemistry 48 4 (2010): 802-814. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955249881&partnerID=MN8TOARS.
    10.1002/pola.23828
  53. Valente, Andreia; Zinck, P.; Vitorino, M.J.; Mortreux, A.; Visseaux, M.. "Rare earths/main group metal alkyls catalytic systems for the 1,4-trans stereoselective coordinative chain transfer polymerization of isoprene". Journal of Polymer Science, Part A: Polymer Chemistry 48 21 (2010): 4640-4647. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649574820&partnerID=MN8TOARS.
    10.1002/pola.24225
  54. Valente, Andreia; Zinck, Philippe; Mortreux, André; Visseaux, Marc. "Catalytic Chain Transfer (co-)Polymerization: Unprecedented Polyisoprene CCG and a New Concept to Tune the Composition of a Statistical Copolymer". Macromolecular Rapid Communications 30 7 (2009): 528-531. http://dx.doi.org/10.1002/marc.200800734.
    10.1002/marc.200800734
  55. Zinck, Philippe; Valente, Andreia; Terrier, Michaël; Mortreux, André; Visseaux, Marc. "Half-lanthanidocenes catalysts via the “borohydride/alkyl” route: A simple approach of ligand screening for the controlled polymerization of styrene". Comptes Rendus Chimie 11 6-7 (2008): 595-602. http://dx.doi.org/10.1016/j.crci.2007.12.006.
    10.1016/j.crci.2007.12.006
  56. Zinck, Philippe; Valente, Andreia; Mortreux, André; Visseaux, Marc. "In situ generated half-lanthanidocene based catalysts for the controlled oligomerisation of styrene: Selectivity, block copolymerisation and chain transfer". Polymer 48 16 (2007): 4609-4614. http://dx.doi.org/10.1016/j.polymer.2007.06.014.
    10.1016/j.polymer.2007.06.014
  57. Zinck, Philippe; Terrier, Michaël; Mortreux, André; Valente, Andreia; Visseaux, Marc. "A New Family of Styrene/Diene Rubbers". Macromolecular Chemistry and Physics 208 9 (2007): 973-978. http://dx.doi.org/10.1002/macp.200700055.
    10.1002/macp.200700055
Online resource
  1. Côrte-Real, L.; Mendes, Filipa; Coimbra, Joana; Morais, Tânia S; Tomaz, Ana Isabel; Valente, Andreia; Garcia, Maria Helena; Santos, Isabel; Bicho, Manuel. Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes. 2014. https://globalmedicaldiscovery.com/?s=Anticancer+activity+of+structurally+related+ruthenium%28II%29+cyclopentadienyl+complexes.
Thesis / Dissertation
  1. Valente, Andreia. "Lanthanide based coordinative chain transfer polymerization for architecture control in (co)polymers and ruthenium catalysed ring-opening polymerization: two aspects of atom economy in polymerization catalysis". PhD, Université de Lille, 2010.
  2. Valente, Andreia. "Ruthenium metallocene syntheses and evaluation of their potentialities as anticancer agents". Master, Faculdade de Ciências, Universidade de Lisboa, 2007.

Intellectual property

Patent
  1. Maria Helena Garcia; Valente, Andreia; Tânia S. Morais; Ana Isabel Tomaz. 2016. "Macromolecular Transition Metal Complexes For Treatment Of Cancer And Process For Their Preparation".
    Granted/Issued
Provisional application for patent
  1. 2023. "Use Of An Organometallic Ruthenium Compound For The Prevention And/Or Treatment Of Diseases And/ Or Conditions Related To Cancer In An Individual.".
    Disclosed

Other

Other output
  1. A new ruthenium-cyclopentadienyl compound as a promising cancer MDR reversing agent. Oral communication given at CQE Days 2023.. 2023. Valente, Andreia; Ricardo G. Teixeira; Maximiano, Inês; Oliveira, N. F. B.; Sequeira, João G. N.; Antunes A; Machuqueiro, Miguel.
  2. "Ruténio - o elemento que não para de nos surpreender!" In “Os Elementos em Ciências - Uma viagem pela Tabela Periódica. (Editors: A. Mourato, A. Paula Carvalho, F. Leitão, T. Pamplona), 2020, Faculdade de Ciências da Universidade de Lisboa.. 2020. Valente, Andreia; Morais, Tânia S; Garcia, M. Helena.
Spin-off company
  1. 2021. R-nuucell. Development of anticancer drugs. http://www.r-nuucell.com/.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/03/08 |Invited Seminar| From test tube to the clinic: the search for a new ruthenium anticancer agent, A. Valente Lecture on the on the Post-Graduated Course – Cancer Therapy: from basic research to clinic. 8th Edition. Post-Graduated Course – Cancer Therapy: from basic research to clinic. 8th Edition
(by Zoom, Portugal)
2024/03/06 |Invited Seminar| Andreia Valente, "Ruthenium-cyclopentadienyl complexes as chemosensitizers in cisplatin-resistant cancers", presented at Workshop on "Breakthroughs of non-platinum anticancer metallopharmaceuticals" Workshop on "Breakthroughs of non-platinum anticancer metallopharmaceuticals"
(Lisboa, Portugal)
2024/01/05 |Invited Seminar| From test tube to the clinic: the search for a new ruthenium anticancer agent, A. Valente lecture in the frame of the UC "Quimioterapia com compostos de alguns elementos não essenciais" for the M.Sc. in Pharmaceutical Sciences and Graduation in Biochemistry from Universidade Lusófona
(by Zoom, Portugal)
2023/05/04 |Invited Seminar| From test tube to the clinic: the search for a new ruthenium anticancer agent, A. Valente Lecture on the on the Post-Graduated Course – Cancer Therapy: from basic research to clinic. 7th Edition.
Department of Biology, Universidade do Minho (Braga, Portugal)
2023/05 |Invited Seminar| Targeting aggressive cancers with ruthenium compounds, A. Valente Lecture on the on the Post-Graduated Course – Cancer Therapy: from basic research to clinic. 6th Edition. 20-31 May 2022, Department of Biology, Universidade do Minho
Department of Biology, Universidade do Minho (Braga, Portugal)
2023/04/24 |Invited Seminar| From test tube to the clinic: the search for a new ruthenium anticancer agent, A. Valente Lecture in the frame of the UC “Biotecnologia Molecular” from the M.Sc. in Molecular Biology and Genetics from FCUL
Faculdade de Ciências, Universidade de Lisboa (Lisboa, Portugal)
2023/01/01 |Invited Seminar| From test tube to the clinic: the search for a new ruthenium anticancer agent, A. Valente lecture in the frame of the UC "Quimioterapia com compostos de alguns elementos não essenciais" for the M.Sc. in Pharmaceutical Sciences and Graduation in Biochemistry from Universidade Lusófona
Universidade Lusófona (Lisboa, Portugal)
2022/09/28 |Invited| Specific Targeting for Colorectal Cancer Harboring KRAS Mutation Using a New Ruthenium-Based Agent, A. R. Brás, A. Lopes, N. Mendes, P. Fernandes, T. Moreira, F. Gärtner, A. Valente, A. Preto* 6th Cancer World Congress
(Lisboa, Portugal)
2022/07/15 Iron-cyclopentadienyl compounds with phosphane and N-based ligands show strong activity against a broad panel of human cancer cell lines - Adhan Pilon*, M. Helena Garcia, Andreia Valente 2nd Chem & Biochem Students Meeting
Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa (Lisboa, Portugal)
2022/03/29 Novel ruthenium-cyclopentadienyl agents targeting KRAS mutated colorectal cancer - Brás AR*, Fernandes P, Moreira T, Valente A, Preto A. 13th Inorganic & Bioinorganic Chemistry Conference
(Aveiro, Portugal)
2022/03/10 Overcoming cancer multidrug resistance with ruthenium cyclopentadienyl compounds - Andreia Valente* 8th Latin American Symposium on Coordination and Organometallic Chemistry
2021/12/17 |Invited Seminar| From test tube to the clinic: the search for a new ruthenium anticancer agent, A. Valente Lecture in the frame of the UC "Quimioterapia com compostos de alguns elementos não essenciais" for the M.Sc. in Pharmaceutical Sciences and Graduation in Biochemistry from Universidade Lusófona
Universidade Lusófona (Lisboa, Portugal)
2021/01/19 |Invited Seminar| From test tube to the clinic: the search for a new ruthenium anticancer agent, Andreia Valente Lecture in the frame of Inorganic Medicinal Chemistry for the M.Sc. in Pharmaceutical Sciences and Graduation in Biochemistry from Universidade Lusófona
Universidade Lusófona (Lisboa, Portugal)
2021 Overcoming cisplatin resistance in lung cancer using Ru(II) compounds - Ricardo G. Teixeira*, Ana Isabel Tomaz, M. Helena Garcia, Andreia Valente 3rd CQE Days Spring meeting
(Online Meeting, Portugal)
2021 |Invited| Ruthenium cyclopentadienyl compounds as prospective anticancer metallodrugs - A. Valente* Virtual Conference on Organometallic Chemistry EuCOMC XXIV
(Madrid, Spain)
2020/11/01 Iron-cyclopentadienyl compounds with nitrile-based ligands show strong activity against a broad panel of human cancer cell lines - Adhan Pilon*, M. Helena Garcia, Andreia Valente 6th International Electronic Conference on Medicinal Chemistry, electronic conference
2020/05/22 |Invited Seminar| Targeted cancer therapy using ruthenium compounds, Andreia Valente Lecture on the “Sessões CBIOS 2019/2020”
Universidade Lusófona (Lisboa, Portugal)
2020/05 |Invited Seminar| Targeted cancer therapy using ruthenium compounds, Andreia Valente Lecture on the Post-Graduated Course – “Bionanoparticles: challenges and therapeutic opportunities”. 4th to 15rd of May 2020
Department of Biology, Universidade do Minho (Braga, Portugal)
2020/02/27 Ruthenium-cyclopentadienyl bipyridine-biotin based compound: P-gp inhibition and activity against resistant cancer cells - Andreia Valente*, Leonor Côrte-Real, M. Helena Garcia, Marie Ehrlichova, Radka Vaclavikova STRATAGEM CA17104 Annual Conference, 3rd meeting and 4th WGs meeting
(Belgrade, Serbia)
2020/01/30 Chemical and Biological Applications of Cyclam-Based Copper(II) Complexes - Luis G. Alves*, Adhan Pilon, Andreia Valente, Ana M. Martins III International Workshop on Chemistry of Group 11 Elements
(Caparica, Portugal)
2020/01/16 Fighting Breast Cancer with Ruthenium-based Metallodrugs endowed with Tumor-targeting Vectors - Leonor Côrte-Real*, Ana Rita Brás, Ana Preto, M. Helena Garcia, Andreia Valente 13º Encontro Nacional de Química Orgânica/6º Encontro Nacional de Química Terapêutica
(Aveiro, Portugal)
2019/12/04 |Invited| Strategies for targeted cancer therapy using ruthenium-cyclopentadienyl complexes - A. Valente*, Leonor Côrte-Real, Ana Rita Brás, M. Helena Garcia, Ana Preto 3rd International Caparica Christmas Congress on Translational Chemistry
(Caparica, Portugal)
2019/09/05 |Invited| New Ruthenium-Cyclopentadienyl Complexes Bearing Biotinylated (Macro)Ligands: Targeting Strategies To Fight Metastatic Breast Cancer - Leonor Côrte-Real*, Ana Rita Brás, Ana Preto, M. Helena Garcia, Andreia Valente 6th Young Medicinal Chemist Symposium (EFMC-YMCS 2019), 5-6 September 2019
(Athens, Greece)
2019/07/26 |Invited| Fighting metastatic cancers with ruthenium cyclopentadienyl compounds - Andreia Valente* XXVI Encontro Nacional da Sociedade Portuguesa de Química
(Porto, Portugal)
2019/06/24 |Invited| Targeting cancer with selective and potent ruthenium compounds - Andreia Valente* 6th World Congress on Natural Product & Synthetic Chemistry (Synthetic Chemistry 2019)
(New York, USA)
2019/06/24 |Invited| Progress on the design of metal-based drugs for cancer therapy - M. Helena Gracia*, Tânia S. Morais, Andreia Valente, Ana Isabel Tomaz 6th World Congress on Natural Product & Synthetic Chemistry (Synthetic Chemistry 2019),
(New York, USA)
2019/05/31 Novel ruthenium complexes as potent anticancer agents: strategies for targeted therapy - Andreia Valente* CQE Days Spring Meeting
(Lisboa, Portugal)
2019/05 |Invited Seminar| Strategies for targeted cancer therapy using ruthenium complexes, A. Valente Lecture on the on the Post-Graduated Course – Cancer Therapy: from basic research to clinic. 5th Edition. 20-31 May 2019
Department of Biology, Universidade do Minho (Braga, Portugal)
2019/01/30 New ruthenium metallodrugs against cancer multidrug resistance - A. Valente* 2nd MC Meeting and 1st WG1-WG4 meeting of CA17104 – STRATAGEM – New diagnostic and therapeutic tools against multidrug resistant tumors
(Turin, Italy)
2018 On the mode of action of anticancer ruthenium-polymer conjugates - Andreia Valente,* Ana Rita Brás, M. Helena Garcia, Ana Preto International Conference on Coordination Chemistry
(Sendai, Japan)
2018 Novel ruthenium methylcyclopentadienyl complexes bearing bipyridine based ligands with strong anticancer activity - M. Helena Garcia,* Ricardo G. Teixeira, Leonor Côrte-Real, Patrícia Gírio, Andreia Valente International Conference on Coordination Chemistry
(Sendai, Japan)
2018 Ruthenium Cyclopentadienyl Compounds: Cytotoxic Agents Against Resistant Cancer Cells - Andreia Valente*, Leonor Côrte-Real, Helena Garcia 12th Inorganic and Bioinorganic Chemistry Conference
(Porto, Portugal)
2018 Ruthenium drugs: born to cure - Andreia Valente* Ciência 2018
(Centro de Congressos de Lisboa, Portugal)
2018 Novel ruthenium cyclopentadienyl complexes bearing bipyridine based (macro)ligands with strong activity towards cancer cells - Ricardo G. Teixeira, Ana Rita Brás, Leonor Côrte-Real, Rajendhraprasad Tatikonda, M. Helena Garcia, Matti Haukka, Ana Preto, Andreia Valente* 4th European Conference on Smart Inorganic Polymers
(Zagreb, Croatia)
2018 Carboxyphenyl chlorins as platforms for photodynamic therapy of cancer: Synthesis and photophysical studies - José Almeida, Andreia Leite, Luís Cunha-Silva, Maria Rangel, Baltazar de Castro, Andreia Valente, Adhan Pilon, Ana F. R. Cerqueira, Augusto C. Tomé, Ana M. G. Silva* 4th European Conference on Smart Inorganic Polymers
(Zagreb, Croatia)
2017/12/05 |Invited| ABC proteins: targets for ruthenium-cyclopentadienyl anticancer compounds? - Andreia Valente*, Patrícia Gírio, Leonor-Côrte-Real, Ricardo Teixeira, Pierre Falson, M. Helena Garcia II International Caparica Christmas Congress on Translational Chemistry
(Caparica, Portugal)
2017/08/08 |Invited| Unprecedented polymer-metal vesicles as efficient anticancer agents - M. Helena Garcia*, L. Côrte-Real, A. P. Soto, C. Rodrigues, A. R. Fernandes, A. Valente SILQCOM 2017
(Puerto Iguazú, Misiones, Argentina)
2017/05/20 |Invited| Ruthenium compounds as metallodrug candidates for cancer therapy - Ana Isabel Tomaz*, Andreia Valente, Tânia S. Morais, Fernanda Marques, M. Helena Garcia, BIT’s 10th annual world cancer congress
(Barcelone, Spain)
2017/05 |Invited Seminar| From test tube to the clinic: the search for an anticancer agent for triple negative breast cancer, A. Valente Lecture on the on the Post-Graduated Course – Cancer Therapy: from basic research to clinic. 15-26th May 2017
Department of Biology, Universidade do Minho (Braga, Portugal)
2017 Novel ruthenium-cyclopentadienyl complexes as potential candidates to surmount multidrug resistance in cancer - Côrte-Real L.*, Gírio P., Moreno A., Garcia M. H., Falson P., Valente A. UL Chemsitry PhD Meeting (2ECQUL)
(Lisboa, Portugal)
2017 Adenine end-capped polylactide: Synthesis via adenine organocatalyzed ring-opening polymerization of lactide And application in cancer therapy - Guilherme Nogueira, Audrey Favrelle, Marc Bria, João P. Prates Ramalho, Paulo J. Mendes, Andreia Valente, Philippe Zinck* 6th International Conference on Biobased and Biodegradable Polymers (BIOPOL-2017)
(Mons, Belgium)
2017 Ruthenium-cyclopentadienyl’ moiety: a versatile scaffold for the design of anticancer agents. - Andreia Valente*, Adhan Pilon, Anabela Sanches, Leonor Côrte-Real, Ricardo Teixeira, M. Helena Garcia SILQCOM 2017
(Puerto Iguazú, Misiones, Argentina)
2017 New self-assembled polymer-metal compounds: highly efficient anticancer vesicles - Leonor Côrte-Real*, Alejandro P. Soto, Ana S. Viana, Alexandra R. Fernandes, M. Helena Garcia, Andreia Valente Chem&BioChem postgraduate students meeting
(Lisboa, Portugal)
2016/11/22 |Invited| Targeting cancer with new multifunctional metallodrugs - Andreia Valente*, Leonor Côrte-Real, Tiago Moreira, Ana Preto, M. Helena Garcia World Congress on Cancer Research and Therapy
(Miami, United States)
2016/11/22 |Invited| Ruthenium new drugs: a promising future for cancer therapy? - M. Helena Garcia*, Andreia Valente, Tânia S. Morais, Isabel Tomaz World Congress on Cancer Research and Therapy
(Miami, United States)
2016/07/04 |Invited Seminar| From test tube to the clinic: the search for an anticancer agent for triple negative breast cancer, A. Valente
Lodz University of Technology (Lodz, Poland)
2016/06/18 |Invited| Polymer-metal conjugates: versatile scaffolds for the synthesis of new antitumor drugs - Andreia Valente*, Leonor Côrte-Real, Guilherme Nogueira, Anabela Sanches, Fernanda Marques, Francisco Tortosa, Fátima Gärtner, Nuno Mendes, M. Helena Garcia European Chemistry Congress
(Rome, Italy)
2016/06/18 |Invited| Ruthenium Organometallic compounds as promising anti- metastatic drugs for breast cancer chemotherapy - M. Helena Garcia*, Andreia Valente, Tânia S. Morais, Fernanda Marques European Chemistry Congress
(Rome, Italy)
2016/05 |Invited Seminar| Targeted cancer nanotherapy using metal-polymer conjugates, A. Valente Lecture on the Post-graduated course – “Bionanoparticles: challenges and therapeutic opportunities”, 23rd May to 3rd June 2016
Departamento de Biologia, Universidade do Minho (Braga, Portugal)
2016/04/27 |Invited Seminar| Ruthenium-polymer conjugates: new promising anticancer agents, A. Valente, Conferences Cycle from Centro de Química de Évora, Ph.D. Program in Chemistry and M.Sc. in Chemistry
Universidade de Évora (Évora, Portugal)
2016 Strategical synthesis of porphyrinic carboxylate ligands as promising photosensitizers for photodynamic therapy of cancer - J. Almeida*, A. Leite, A. M. N. Silva, L. Cunha-Silva, B. de Castro, M. Rangel, A. Pilon, A. Valente, A. M. G. Silva Third European Conference on Smart Inorganic Polymers
(Porto, Portugal)
2016 Self-assembled polymer-ruthenium micelles: new promising anticancer agents - Leonor Côrte-Real*, Alejandro P. Soto, Ana S. Viana, M. Helena Garcia, Andreia Valente Third European Conference on Smart Inorganic Polymers
(Porto, Portugal)
2016 Self-assembled polymer-metal micelles: new promising anticancer agents - Leonor Côrte-Real*; M. Helena Garcia; Ana S. Viana; Andreia Valente 5PYChem/EyChem
(Guimarães, Portugal)
2015/12/09 |Invited| Multifunctional polymer-ruthenium cyclopentadienyl complexes: new promising anticancer agents - A. Valente*, M.H. Garcia, A. Pilon, A.P. Matos, F. Mendes, M.A.F. Faustino, N. Mendes, F. Gärtner, A. Preto, R. Francisco, F. Marques I International Caparica Christmas Congress on Translational Chemistry
(Caparica, Portugal)
2015/11/04 |Invited| Ruthenium drugs for cancer therapy: small structural changes, different in vivo performances - M. Helena Garcia*, Tânia S. Morais, A. Isabel Tomaz, Fernanda Marques, Andreia Valente 4th International Conference on Medicinal Chemistry & Computer Aided Drug Designing
(Atlanta, United States)
2015/11/03 |Invited| On the mode of action of new promising anticancer agents: multifunctional polymer-ruthenium conjugates - A. Valente*, M.H. Garcia, A. Pilon, A.P. Matos, F. Tortosa, N. Mendes, F. Gärtner, A. Preto, R. Francisco, B. T. Buckley, F. Marques 4th International Conference on Medicinal Chemistry & Computer Aided Drug Designing
(Atlanta, United States)
2015/06/17 |Invited Seminar| Ruthenium drugs: born to kill, A. Valente Chemforum
Instituto Superior Técnico (Lisboa, Portugal)
2015/05 |Invited Seminar| Medicinal Inorganic Chemistry: Metal-polymer conjugates for cancer therapy, Andreia Valente Lecture on the Post-Graduated Course – Cancer Therapy: from basic research to clinic. 8-19 June 2015
Department of Biology, Universidade do Minho (Braga, Portugal)
2015 Multifunctional polymer-ruthenium conjugates: new promising anticancer agents - Andreia Valente*, L. Côrte-Real, A.P. Matos, M. H. Garcia, F. Marques 2nd European Conference on Smart Inorganic Polymers,
(Upsalla, Sweden)
2015 Access to a new type of thermoplastic elastomer via rare earth catalysts mediated chain shuttling polymerization - Andreia Valente, Thibaut Pinalie, Fanny Bonnet, Grégory Stoclet, Jean-Marc Lefèbvre, Marc Visseaux, André Mortreux, Philippe Zinck* Eufen 4, Fourth joined meeting of COST Action CM1006: European f-Element Chemistry
(Lisboa, Portugal)
2014/12/08 |Invited| Polymer ´ruthenium-cyclopentadienyl` conjugates: a new approach to fight cancer - Andreia Valente*, M. Helena Garcia, Leonor Côrte-Real, Guilherme Nogueira, Philippe Zinck, António Matos, Fernanda Marques, 3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing
(San Francisco, United States)
2014/12/08 |Invited| Tracking antitumor drugs: ruthenium(II) cyclopentadienyl complexes as promising agents - M. Helena Garcia*, Tânia Morais, Andreia Valente, Fernanda Marques 3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing
(San Francisco, United States)
2014/11/24 |Invited Seminar| Polymer ‘ruthenium-cyclopentadienyl’ conjugates: a new approach to fight cancer, Andreia Valente
École Nationale Supérieure de Chimie de Lille (Lille, France)
2014/11/17 |Invited| Finding Homes for all of the Orphan Assays - Brian Buckley*, Andreia Valente, Ill Yang, Min Liu, Kyle Buckley, Frances Acevedo Mariani, Stephanie Marco, Elizabeth McCandlish Eastern Analytical Symposium
(Somerset NJ, United States)
2014/07/10 Access to amorphous thermoplastic elastomers of tunable transition temperatures via chain shuttling copolymerization (Invited) - Andreia Valente, Grégory Stoclet, Fanny Bonnet, André Mortreux, Marc Visseaux, Philippe Zinck* IUPAC World Polymer Congress
(Chiang Mai, Thailand)
2014/05/23 |Invited Seminar| Metal-polymer conjugates for cancer therapy, Andreia Valente Post-graduated course Bionanotechnology for diagnosis and therapy of cancer”, 19-30 May 2014, CBMA
Department of Biology, Universidade do Minho (Braga, Portugal)
2014/01/29 |Invited Seminar| New polymer ‘ruthenium-cyclopentadienyl’ complexes for drug delivery in cancer therapy, Andreia Valente CCMM Seminars
Faculdade de Ciências, Universidade de Lisboa (Lisboa, Portugal)
2014 New ruthenium-polymer conjugates for drug delivery in cancer therapy - Guilherme Nogueira*, Andreia Valente 2º Encontro Nacional de Estudantes de Química
(Covilhã, Portugal)
2014 |Invited Seminar| New polymer-ruthenium conjugates for drug delivery in cancer chemotherapy, Andreia Valente Lecture on Inorganic Biochemistry from the 2nd academic year of the Biochemistry Course
Faculdade de Ciências, Universidade de Lisboa (Lisboa, Portugal)
2013/10/16 New polymeric “ruthenium-cyclopentadienyl” complexes for drug delivery in cancer therapy (Invited) - Andreia Valente*, M. Helena Garcia, Fernanda Marques, Philippe Zinck 2nd International Conference on Medicinal Chemistry & Computer Aided Drug Designing
(Las Vegas, United States)
2013 New polymer-ruthenium conjugates for targeted drug delivery in cancer chemotherapy (Flash Presentation) - Andreia Valente*, M. H. Garcia, F. Marques, P. Zinck Nanoparticles for early Diagnostics of inflammatory diseases
(Lisboa, Portugal)
2012 Polydentate Octhaedric Ru Complexes: Synthesis, Characterization, Anti-Tumour Activity and Interaction with Human Serum Proteins (Flash Presentation) - Matos, C.P.*; Valente, A.; Marques, F.; Adão, P.; Robalo, M.P.; Almeida, R.F.M.; Costa Pessoa, J.; Garcia, M.H.; Tomaz, A.I. XXV International Conference on Organometallic Chemistry
(Lisboa, Portugal)
2012 New polydentate Ru(III)-Salan complexes: synthesis, characterization, antitumour activity and interaction with human serum proteins - Cristina P. Matos, Andreia Valente, Fernanda Marques, Pedro Adão, Rodrigo F. M. Almeida, João Costa Pessoa, M. Helena Garcia, Ana Isabel Tomaz* International Symposia on Metal Complexes – ISMEC
(Lisboa, Portugal)
2012 Coordinative chain transfer polymerization: recent advances and a new paradigm using rare earth catalysts - A. Valente, P. Zinck*, A. Mortreux, M. Visseaux Eufen 1, First joined meeting of COST Action CM1006: European f-Element Chemistry
(Tarragone, Spain)
2011 Dois aspectos para uma economia de catalisador em polimerizações por transferência de cadeia - Andreia Valente* Ciência QB - 1º Encontro dos Alunos de Doutoramento do DQB
(Lisboa, Portugal)
2009 Polymérisation coordinative par transfert de chaîne: vers de nouvelles applications - Andreia Valente* Journée des jeunes chercheurs en polymère
(Lille, France)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - Current Multifunctional Ruthenium and Selenium Drugs to Overcome Multidrug Resistance in Cancer
Supervisor of Catarina Henriques
 Doutoramento em Química (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023 - Current Investigação sobre fontes alternativas de melanina marinha aplicadas à energia solar térmica. Estudo de pigmentos e nanomaterais em fluídos de transferência de calor
Co-supervisor of Rafael Marçal Almeida
 Doutoramento em Química Tecnológica (PhD)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2023 - Current |Final Graduation Project| Síntese e caracterização de novos complexos de prata(I) para a terapia do cancro
Supervisor of Daniela Lino
 Química
Faculdade de Ciências, Universidade de Lisboa, Portugal
2022 - Current Uncover the mechanism of action of new FeCp compounds in colorectal cancer cells
Co-supervisor of Ana Paula Passos da Silva
 Mestrado em Biologia Celular e Molecular (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2019/03/01 - Current New ruthenium-based anticancer agents: promising therapeutic approach towards colorectal cancer
Co-supervisor of Ana Rita Brás
 Biologia Molecular e Ambiental (PhD)
Universidade do Minho, Portugal
2019/01/01 - Current Targeting cancer with ruthenium compounds
Supervisor of Ricardo Teixeira
 Química (PhD)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2019/01/01 - Current New multifunctional drug delivery systems for cancer therapy via innovative polymerization strategies
Supervisor of Adhan Pilon
 Química (PhD)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2021 - 2023 Estudo da estabilidade de agentes de contraste do gadolínio em diferentes condições ambientais estuarinas
Co-supervisor of Ana Guerreiro
 Mestrado em Química Tecnológica (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2020 - 2023 Integração de requisitos GMP’s e ISSO 17025 para Qualificação de equipamentos e Validação de Sistemas na Indústria Farmacêutica no ISQ
Co-supervisor of Catarina Santos
 Mestrado em Química Tecnológica (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2021 - 2022 Pre-clinical studies against colorectal cancer for a prospective ruthenium anticancer metallodrug
Supervisor of Ana Lopes
 Mestrado em Bioquímica (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2021 - 2022 Avaliação da interação de potenciais metalofármacos de ruténio com proteínas do sangue por ressonância magnética nuclear (final graduation project)
Co-supervisor of Bruno Severino
 Licenciatura em Química Tecnológica (Degree)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2020/09/01 - 2021 On the mode of action of prospective ruthenium anticancer metallodrugs and their metabolic and plasma stability
Supervisor of Inês Maximiano
 Bioquímica (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2020 - 2021 Potenciais metalofármacos de ruténio: estudos de formulação para administração intravenosa (final graduation project)
Supervisor
 Licenciatura em Química Tecnológica (Degree)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2020 - 2021 Síntese e caracterização de complexos bimetálicos com potencial aplicação como agentes anti-tumorais (final graduation project)
Supervisor of Neuza Salgado
 Licenciatura em Química (Degree)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2019/11/01 - 2020/09/01 Síntese e caracterização de complexos de Molibdénio como sistemas de libertação de CO para o tratamento do cancro
Co-supervisor
 Química (Degree)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2019/11/01 - 2020/07/20 Novos complexos de ruténio contendo benzonitrilos derivatizados como potenciais agentes anticancerígenos
Supervisor of Jorge Valentim
 Química (Degree)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2019/03/01 - 2019/07/24 Síntese de novos complexos de metais endógenos com potencial anticancerígeno (Final Graduation Project)
Supervisor of Beatriz Moreno
 Química (Degree)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2019/01/01 - 2019/07/23 Desenvolvimento de novos complexos de ruténio com derivados da curcumina como potenciais agentes anticancerígenos (Final Graduation Project)
Supervisor of Rita Soares
 Química Aplicada (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/02/01 - 2019/06/04 Polymer-metal based compounds to target (non)hormone-responsive cancers: synthesis and mechanistic evaluation
Supervisor of Leonor Côrte-Real
 Química (PhD)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2018/02/01 - 2018/07/23 Síntese, caracterização e avaliação biológica de novos complexos de ruténio derivatizados com glucose para terapia dirigida do cancro (Final Graduation Project)
Supervisor of Bernardo Henriques
 Química (Degree)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2016/09/01 - 2017/07/05 The role of ABC proteins in the mechanism of action of promising ruthenium anticancer agents
Supervisor of Patrícia Gírio
 Química (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2016 - 2017 Synthesis of new 3D-?5-carboranyl ruthenium complexes incorporating polymeric ligands towards combinatory therapy of cancer
Supervisor of Ricardo Teixeira
 Química (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2016 - 2017 Unraveling the molecular targets of new ruthenium-based anticancer drugs
Co-supervisor of Ana Rita Brás
 Genética Molecular (Master)
Universidade do Minho, Portugal
2015 - 2017 Development of new metalodrugs: new ruthenium complexes bearing macromolecular ligands as antitumor agents
Co-supervisor of Maria Inês Pereira
 Química (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2015 - 2016 A importância de moléculas azotadas nas estruturas poliméricas de novos complexos de ferro macromoleculares como agentes anticancerígenos”
Supervisor of Adhan Pilon
 Química Tecnológica (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2015 - 2016 New metal-based micelles as targeted anticancer agents
Co-supervisor of Bebiana Pinto
 Química (Master)
Universidade de Évora, Portugal
2015 - 2016 Unraveling the molecular targets of new ruthenium-based anticancer drugs
Co-supervisor of Tiago Moreira
 Genética Molecular (Master)
Universidade do Minho, Portugal
2015 - 2016 Development of new ruthenium compounds as potential drugs for the treatment of hypophysis adenomas
Supervisor of Anabela Sanches
 Química (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2015 - 2016 New iron cyclopentadienyl complexes as anticancer agents: a structure-activity study (Final Graduation Project)
Supervisor of Patrícia Gírio
 Química (Degree)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2015 - 2016 Diretos ao Alvo: Virtual Screening de potenciais fármacos usando uma biblioteca de compostos com interesse farmacêutico (Final Graduation Project)
Co-supervisor of Carla Antunes
 Química Tecnológica (Degree)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2014 - 2015 Functionalization of biocompatible polyesters with substrates of biological interest via organocatalyzed ring-opening polymerization: application in cancer therapy
Supervisor of Guilherme Nogueira
 Química Tecnológica (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2013/02/01 - 2014/07/19 Development of potential metallodrugs for cancer therapy (Final Graduation Project)
Supervisor of Ricardo Teixeira
 Química (Degree)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2013/01/01 - 2014/07/17 New ruthenium-polymer complexes syntheses in view of photodynamic therapy in melanoma cancer (Final Graduation Project)
Supervisor of Adhan Pilon
 Química Tecnológica (Degree)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2012/09/01 - 2013/07/23 New ruthenium-polymer complexes syntheses for controlled drug delivery in cancer therapy (Final Graduation Project) - Awarded with a with a Amadeu Dias Scholarship
Supervisor of Guilherme Nogueira
 Química Tecnológica (Degree)
Faculdade de Ciências, Universidade de Lisboa, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/03/24 - Current Jornadas da Química Tecnológica 2023, subjacente a tema, emprego: a versatilidade dos “tecnológicos” Contou com a presença de atuais e antigos alunos, docentes, empregadores e mesa redonda. (2023) Faculdade de Ciências, Universidade de Lisboa, Portugal
2016/09/12 - 2016/09/14 3rd European Conference on Smart Inorganic Polymers, Porto, Portugal (2016/09/12 - 2016/09/14)
Conference (Member of the Organising Committee)
2015/11/02 - 2015/11/04 4th International Conference on Medicinal Chemistry & Computer Aided Drug Designing, Atlanta, USA (2015/11/02 - 2015/11/04)
Congress (Member of the Organising Committee)
2014/12/08 - 2014/12/10 3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing, San Francisco, USA (2014/12/08 - 2014/12/10)
Congress (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/09/16 - Current Talk to ~30 Professors from Indian Universities organized by the IST international Office in the frame of an Erasmus+ Project - Enprendia Enhancing Woman Entrepreneurship in India (http://enprendia.eu/). Objective: Testimony of a FCUL spin-off (R-nuucell) about the process of moving from research to the market.
Tec Labs – Centro de inovação, Portugal
2022/09/15 - Current Talk to students from ISEG MBA (accompanied by the Startup Lisboa). Objective: to share R-nuucell’s entrepreneurial journey, as well as R-nuucell’s journey in transferring its knowledge to the market.
Tec Labs – Centro de inovação, Portugal
2022/07/20 - Current Women TechEU cocktail sunset – Participation in the round table. Objective: join and celebrate the national entrepreneurial community leading with technological-based companies and contribute to the national mobilization and participation at the European Commission prizes dedicated to women entrepreneurs. After the round table there was a networking moment. Where: Hub Criativo do Beato, Lisboa, Portugal
Hub Criativo do Beato, Portugal
2019/10/30 - Current |Outreach Activities| CIÊNCIAS Research Day 2019 – Presentation of two posters CIÊNCIAS Research Day 2019
Faculdade de Ciências, Universidade de Lisboa, Portugal
2017/05/04 - Current Participation at the round table "Alumni vs. students", http://jornadasqt2017.campus.ciencias.ulisboa.pt/node/4 Jornadas da Química Tecnológica
Faculdade de Ciências, Universidade de Lisboa, Portugal
2015/11/24 - Current Speech within the scientific path of a former Technological Chemistry student Dia da Química Tecnológica
Faculdade de Ciências, Universidade de Lisboa, Portugal
2015 - Current | Outreach Activities | Participation in several activities that promote interaction between the community and FCUL: Dia Aberto DQB, FCUL (2015-2021); Ser Cientista, FCUL (year 2015); Open Lab Days to secondary school students (since 2011 to 2021); SPEED DATING com os cientistas at FCUL (2019)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2020 - 2021 | Outreach Activity | Participation in the European Researchers' Night with the video "Podem os metalofármacos ser uma boa aposta para a terapia do cancro?" - Festival de Curtas - Química para Todos@ULisboa; Vídeo disponível em: https://www.youtube.com/watch?v=Dea38ODk6T4&feature=emb_logo (NEI2020, NEI2021) European Researchers' Night 2020 and 2021

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/02/16 «Corrosão em materiais usados no armazenamento de energia aplicado à tecnologia solar térmica de concentração
President of the jury
 Mafalda Susano Gil (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2023/02/06 Substituição de substâncias perigosas na indústria: análise de alternativas para retardadores de chama halogenados
President of the jury
 Anita Pacheco Jensen (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2023/02/02 Phenol and Formaldehyde Free Offset Printing Ink Resins
President of the jury
 Filipa Marques Bernardes (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2023/02/02 Otimização do processo produtivo de uma tetraciclina de segunda geração na CIPAN
President of the jury
 Aléxia Sofia Granados Serra (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2022/12/20 Caracterização por calorimetria diferencial de varrimento de polímeros e misturas poliméricas para aplicações marinhas. Estudos para a biodegradabilidade.
President of the jury
 André Filipe Batista Mendes (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2022/12/06 Caracterização térmica e reológica de poliolefinas fabricadas no Complexo Industrial de Sines da REPSOL POLÍMEROS
President of the jury
 Gil Vasco da Silva Gonçalves (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2022/10/13 Avaliação das Necessidades de Substituição de Substâncias Perigosas na Indústria Nacional e Análise de Alternativas
President of the jury
 Carina Isabel Cardoso Silva (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2022/09/30 Organometallic Nucleosides: Synthesis of Platinum and Palladium complexes bearing NHeterocyclic carbenes based on nucleosides and their anticancer activity - Ph.D. in Molecular Biosciences - Thesis Committee Main Examiner
(Thesis) Main arguer
 Maria Inês Paiva da Silva Leitão (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2022/01/07 Identificação de oportunidades de melhoria na polimerização e nas unidades de suporte do processo de produção de fibras acrílicas na SGL Composites, S.A.
President of the jury
 Miguel Ângelo da Silva Alves (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2021/04/08 Compatibility study of rosin esters with metallocene catalysed polyolefins in the resin industry
President of the jury
 Joana Filipa Almeida Casimiro (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2020/12/21 Avaliação da pasta solúvel da Caima para produção de fibras Lyocell
President of the jury
 Ana Marta do Rosário Antunes (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal
2020/01/13 Anticancer Organoruthenium(II) Glycoconjugates: Tricks or Treats?
(Thesis) Main arguer
 Sofia Alexandra da Conceição de Carvalho Milheiro (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/11/05 Nuevos complejos de coordinación con el ligando dmoPTA: Avances en la capacidade antiproliferativa
(Thesis) Main arguer
 Elisabet Zenaida Mendoza Nozeman (PhD)
Universidad de La Laguna, Spain
2015/12/10 Development of folate-targeted liposomes for rheumatoid arthritis therapy
(Thesis) Main arguer
 Eugénia Sofia da Costa Nogueira (PhD)
Universidade do Minho, Portugal
2015/11/26 Synthesis of new metal complexes and evaluation of their potential as anticancer agents
(Thesis) Main arguer
 Ana Sofia Assis (Master)
Faculdade de Ciências, Universidade de Lisboa, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021 - Current 44448 Catálise - 1st cycle in Technological Chemistry (homogeneous catalysis block) Química Tecnológica (Licenciatura) Faculdade de Ciências, Universidade de Lisboa, Portugal
2017 - Current Technological Innovation Laboratories / Laboratórios de Inovação Tecnológica (2015/16; 2017/18; 2021/22; 2022/23) Química Tecnológica (Mestrado) Faculdade de Ciências, Universidade de Lisboa, Portugal
2019 - 2022 44446 Técnicas de Caracterização (old UC 44430) - 1st cycle in Chemistry and Technological Chemistry (NMR block responsible) Química + Química Tecnológica (Licenciatura) Faculdade de Ciências, Universidade de Lisboa, Portugal
2018 - 2020 44425 Química Inorgânica Complementar - 1st cycle in Chemistry Química (Licenciatura) Faculdade de Ciências, Universidade de Lisboa, Portugal
2016 - 2019 Molecular Spectroscopy / Espectroscopia Molecular Química + Química Tecnológica (Licenciatura) Faculdade de Ciências, Universidade de Lisboa, Portugal
2016 - 2017 Spectroscopy / Espectroscopia Química (Licenciatura) Faculdade de Ciências, Universidade de Lisboa, Portugal
2011 - 2015 Chemistry / Química Geral Ciências da Engenharia - Engenharia Biomédica e Biofísica (Licenciatura) Faculdade de Ciências, Universidade de Lisboa, Portugal
2010 - 2015 Biochemistry (introductory) / Bioquímica Ciências da Saúde (Licenciatura) Faculdade de Ciências, Universidade de Lisboa, Portugal
2007 - 2009 Chemical Engineering / "Génie Chimique" (Licence) Université de Lille, France

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2022 - Current Accompanying Commission: Nuno Filipe Baltazar Maia Costa de Oliveira - PhD student in Chemistry, Faculdade de Ciências, Universidade de Lisboa. Thesis entitled “Development of computational methods to study and help revert tumor MDR”.
Other
 Faculdade de Ciências, Universidade de Lisboa, Portugal
2018 - Current Accompanying commission of João Miguel Franco Machado, PhD student in Chemistry, Faculdade de Ciências, Universidade de Lisboa. Thesis entitled ´Novos conjugados ruténio-péptido para a terapia seletiva do cancro da mama metastático` Faculdade de Ciências, Universidade de Lisboa, Portugal
2015/01/01 - Current Evaluator for the Fulbright Program in Portugal in the Chemistry area.
Evaluator
 Fulbright Portugal
2023 - 2023 Revision of one project for the Agencia Nacional de Investigación e Innovación (ANII), the main public funding agency in Paraguay.
2022 - 2022 Revision of one project for the Czech Science Foundation (www.gacr.cz/en), the main public funding agency in the Czech Republic supporting all areas of basic research.
Evaluator
 Grantová agentura Ceské republiky
2020 - 2020 PhD student in Chemistry (CATSUS program) from Instituto Superior Técnico, Universidade de Lisboa. Thesis entitled ´Syntheses and reactivity of titanium and zirconium complexes supported by salan- and salen ligands`.
Evaluator
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2020 - 2020 Scientific Expert at the evaluation process of Generic Call 2020 from the Agence Nationale de la Recherche (ANR). https://anr.fr/fr/detail/call/appel-a-projets-generique-2020/
Evaluator
 Agence nationale de la recherche
2019 - 2019 International Expert Reviewer for the FONDECYT Regular 2019 grant competition, an initiative of the Chilean National Science and Technology Commission (CONICYT - Chile) - https://www.conicyt.cl/fondecyt/2018/07/26/concurso-regular-fondecyt-2019/
Evaluator
 CONICYT – National Commission for Science and Technology

Journal scientific committee

Journal title (ISSN) Publisher
2019 - Current Chemical Science (2041-6539) Royal Society of Chemistry
2019 - Current Journal of Inorganic Biochemistry (0162-0134) Elsevier
2018 - Current Inorganica Chimica Acta (0020-1693) Elsevier
2018 - Current Chemistry - An Asian Journal (1861-471X) Wiley-VCH GmbH
2016 - Current Inorganic Chemistry (0020-1669) American Chemical Society
2015 - Current European Journal of Medicinal Chemistry (0223-5234) Elsevier

Mentoring / Tutoring

Topic Student name
2023/05 - 2023/08 Summer project entitled: “Potential of some metal-based compounds as anti-cancer agents” Téo Khalifa, 2nd year of French Engineering in Chemistry (corresponding to the 4nd year of higher ed
2023/04 - 2023/07 Erasmus Summer Project entitled “Development of cupper complexes for cancer therapy” Damien Krasnowolski, 2nd year student from the University and Technological Institute of Béthune
2023/02 - 2023/07 PhD student in Chemical And Pharmaceutical Sciences And Biotechnology from UNICAM - University of Camerino doing a 6-months research period at my laboratory Daphne Romani
2022/06 - 2022/07 Erasmus Summer Project entitled “Synthesis and formulation studies of new prospective metallodrugs considering in vivo administration” Eléna Oliveira, 1st-year student from the M.Sc. in Chemistry and Chemical Engineering, École Nationa
2022/04 - 2022/07 2nd year student from the University and Technological Institute of Béthune, Erasmus Summer Project entitled “Development of iron-polymer conjugates for cancer therapy” Camille Gelle
2021/09 - 2021/12 Short-term scientific mission in the frame of PhD thesis in Advanced Chemistry entitled “New biologically active polyheterometallic complexes containing dmoPTA (3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane)” Andrés Alguacil Alarcón, PhD Student, University of Almería
2021/10 - 2021/11 Short-term scientific mission in the frame of his PhD thesis in Química Sustentável entitled “Synthesis of ruthenium(II)-porfirin/chlorin conjugates” José de Almeida, PhD student, Faculdade de Ciências da Universidade do Porto (FCUP)
2019/07 - 2021/06 PosDoc hired in the frame of A. Valente’s project “Fighting metastatic cancers: prime time for ruthenium” (PTDC/QUI-QIN/28662/2017) Leonor Côrte-Real, PhD
2020/09 - 2020/10 Third year student – Graduate Engineering Programme from École Nationale Superieure de Chimie de Lille, Erasmus Summer Project entitled “New ruthenium compounds as prospective metallodrugs” Amélie da Silva
2019/05 - 2019/08 Undergraduate student from the Chemistry course from École Nationale Superieure de Chimie de Lille, Erasmus Summer Project “The use of biocompatible polymers as drug delivery systems in cancer therapy” Marion Bovolenta
2018/06 - 2018/07 Undergraduate student from the Chemistry course from École Nationale Superieure de Chimie de Lille, Erasmus Summer Project “Biocompatible polymers for application in cancer therapy” Giulia Ottavi
2018/01 - 2018/04 Short Term Scientific Mission on the scope of the COST action CM1302 entitled “Study of the stability and antiproliferative properties of the bimetallic complexes [RuCp(PPh3)2-µ-dmoPTA-1¿P:2k2N,N’-MCl2] (M = Co, Zn)”. Zenaida Mendoza Nozeman, PhD student, Universidad de La Laguna
2015/07 - 2015/10 Summer Internship from Erasmus + Program, undergraduate student from Faculty of Chemistry, Lodz University of Technology. Project titled “Synthesis of biocompatible (co)polymers for application in cancer therapy” Maciej Mackowiak
2014/06 - 2014/07 Summer undergraduate student from University of Puerto Rico, in the frame of the RiSE (Research in Science and Engineering) programme at Rutgers University, USA Frances Azevedo

Other jury / evaluation

Activity description Institution / Organization
2021/04/02 - Current Evaluation Committee - Diana Díaz García, Ph.D. in Inorganic Chemistry. Thesis title: Diseño y caracterización de nanomateriales de nueva generación con aplicaciones avanzadas en química médica. Universidad Rey Juan Carlos, Spain
2020/07/10 - Current Final project for the B.Sc. degree in Chemistry. Project title: “Desenvolvimento de novos complexos organometálicos de cobalto-ciclopentadienilo com potencial aplicação como agentes antitumorais” - Project Main Examiner Faculdade de Ciências, Universidade de Lisboa, Portugal
2019/07/23 - Current Final project for the B.Sc. degree in Chemistry. Project title: “O papel de proteínas séricas na distribuição e modo de ação de metalofármacos com potencial atividade anti-tumoral” - Project Main Examiner Faculdade de Ciências, Universidade de Lisboa, Portugal
2017/07/25 - Current Final project for the B.Sc. degree in Chemistry. Project title: “Síntese de novos complexos de cobre com ligandos tipo tiosemicarbazona com potencial anticancerígeno” - Project Main Examiner Faculdade de Ciências, Universidade de Lisboa, Portugal
Distinctions

Award

2023 R-nuucell was semi-finalist of EIT Catapult 2023-24
European Institute of Innovation & Technology, Hungary
2022 R-nuucell was awarded by the European Innovation Council Women TechEU Innitiative
European Innovation Council, Belgium
2022 ASPIC Patients' Advocacy Award to the poster: Brás AR, Fernandes P, Moreira T, Valente A, Preto A, “Targeting KRAS mutated colorectal cancers with new ruthenium-based drugs” at 5th ASPIC International Congress, 30th June – 1st July 2022, Porto, Portuga
Associação Portuguesa de Investigação em Cancro, Portugal
2021 Innostars Awards Semi-Finalist with the spin-off R-nuucell
EIT Health, Germany
2021 R-nuucell won the Call INNOV-ID from Portugal Ventures, entering their portfolio.
2020 Best oral communication - "Fighting Breast Cancer with Ruthenium-based Metallodrugs endowed with Tumor-targeting Vectors" (authors: Leonor Côrte-Real,* Ana Rita Brás, Ana Preto, M. Helena Garcia, Andreia Valente)
Universidade de Aveiro, Portugal
2019 Best Oral Communication Prize: Andreia Valente, “Novel ruthenium complexes as potent anticancer agents: strategies for targeted therapy”
2017 Best Poster Prize: P. Girio, A. Moreno, M. H. Garcia, P. Falson, A. Valente, “ABC proteins: targets for ruthenium-cyclopentadienyl anticancer metallodrugs?” V Encontro Nacional De Estudantes De Química, 07-10 April 2017, Coimbra, Portugal
2017 Best oral Communication, L. Côrte-Real, A.P. Soto, A.S. Viana, A.R. Fernandes, M.H. Garcia, A. Valente, “New self-assembled polymer-metal compounds: highly efficient anticancer vesicles”, Chem&BioChem postgraduate students meeting, 9th Feb 2017, Lisbon
2017 RSC Travel for the ICBIC18 – International Conference on Biological Inorganic Chemistry, July, 31st – August, 4th – 2017 - Florianópolis – Brazil.
Royal Society of Chemistry, United Kingdom
2016 Royal Society of Chemistry Research Fund Grant, “Multifunctional polymer-metal complexes: an innovative approach to treat cancer”
Royal Society of Chemistry, United Kingdom
2015 1st position in the ScienceIN2Business 2015 call (M. Helena Garcia, Andreia Valente, Ana Isabel Tomaz, Tânia Morais, “RuPharma”)
2015 Young Investigator Award at the 2nd European Conference on Smart Inorganic Polymers, Upsalla, Sweden
2014 Fulbright grant for Portuguese Scholars and Researchers, Jan – March 2015
2013 Best poster prize, M. Helena Garcia, Tânia S. Morais, Ana Isabel Tomaz, Andreia Valente, Fernanda Marques, "Cyclopentadienyl ruthenium (macro)metallodrugs: large spectrum antitumor agents”
2010 Travel Grant to the Third European Chemical Society Congress (EuCheMS, Nürnberg, Germany, 2010)

Other distinction

2022 R-nuucell was the only Portuguese company selected to participate at Healthcare EIC Investor Day, 29 & 30 November, Lisboa, organized by .European Innovation Council and CUF Hospitals
2015 Biographical profile in the Marquis Who’s Who in the World 2016 - 33rd Edition (Classic); ISBN: 978-0-8379-1156-4.
2013 Media Citation - “Cancro: Portuguesas vencem prémio mundial nos EUA"
2013 Media Citation - Portuguese news
2007 Invitation to the cover of the Journal Macromolecular Chemistry and Physics (2007, 208, 973-978) with the paper entitled “A New family of Styrene/Diene Rubbers”