Andreia Marques Valente (9F1B-8F8A-EBE6)

Curriculum Vitae

A. Valente has a PhD in Chemistry from the Université Lille I-Sciences et Technologie, France (2010), whereby she acquired experience in polymerization catalysis and organometallic synthesis (lanthanides and ruthenium). She joined FCUL in 2010 where she did 2 postdocs in distinct areas of organometallic chemistry (non-linear optics and biomedical). In 2014, after a very competitive call, AV started an FCT Investigator position and independent research at CQE-FCUL where she developed polymer-metal conjugates for targeted cancer therapy. She merged her know-how in organometallic chemistry with her expertise in polymers to create this innovative family of compounds. The important results led AV`s team to patent this work (WO2016/087932) that has secured private investment and led to the creation of a spin-off (Something in Hands - Investigação Científica, Lda; rebranded as R-nuucell). R-nuucell has been a semi-finalist in the very competitive EIT Health InnoStars Awards 2021 and of EIT Health Catapult 2023-24 and has been one of the awardees of the Women TechEU (European Innovation Council). In 2019 AV won a contract in the frame of the CEEC Individual 2017 confirming the potential of her scientific path and research. During the last years, she expanded her panel of expertise, while at Rutgers University, USA, under the scope of a Fulbright Grant, in cell proliferation and viability assays, flow cytometry, and speciation and metal quantification by ICP-MS. So, AV path is marked by a thematic mobility and competences synergy allowing her to gain an extensive and wide-ranging experience in several key areas for the successful development of new anticancer drugs. She has so far 54 papers in international peer review journals (27 as senior corresponding author), 6 book chapters, and several conference proceedings, and was (co)author of ~75 talks in national and international conferences and seminars in post-graduate courses. AV was the Principal Investigator of two research projects funded by the Portuguese Foundation for Science and Technology (FCT), of a Royal Society of Chemistry (RSC) project and was coordinator of the project CanceRusolution from Women TechEU. Presently, AV is the PI of an Innovation project awarded by FCUL and FCiências.ID. AV also participated in two COST actions and in two Transnational Cooperation Programmes and is currently team member of the COST action EURESTOP (CA21145). AV was also responsible for the scientific supervision and initiation to research of several students (15 grad. projects; 13 international projects (Erasmus or STSM), 16 MSc + 6 PhD thesis + 2post-doc).

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Identification

Personal identification

Full name: Andreia Marques Valente

Citation names

Valente, Andreia

Author identifiers

Ciência ID: 9F1B-8F8A-EBE6
ORCID iD: 0000-0002-3370-208X
Google Scholar ID: https://scholar.google.pt/citations?hl=en&user=F19hQbYAAAAJ
Researcher Id: D-9251-2011
Scopus Author Id: 23570219600

Addresses

Faculdade de Ciências da Universidade de Lisboa, DQB, Ed. C8,, Campo Grande, 1749-016, Lisboa, Lisboa, Portugal (Professional)

Websites

www.lead4target.com (Professional)
https://haticancer.weebly.com/ (Professional)
http://www.r-nuucell.com/ (Professional)

Languages

Language	Speaking	Reading	Writing	Listening
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
Portuguese	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
French	Intermediate (B1)	Intermediate (B1)	Beginner (A1)	Intermediate (B1)

Education

	Degree	Classification
2010 Concluded	Molécules et Matières Condensée (Docteur) Université des Sciences et Tecnhologie de Lille 1, France "Lanthanide based coordinative chain transfer polymerization for architecture control in (co)polymers and ruthenium catalyzed ring-opening polymerization: two aspects of atom economy in polymerization catalysis" (THESIS/DISSERTATION)	Très Honorable
2007 Concluded	Química Inorgânica Biomédica - Aplicações em Diagnóstico e Terapia (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal "Síntese de metalocenos de ruténio e avaliação das suas potencialidades antitumorais" (THESIS/DISSERTATION)	Muito Bom (19 Valores)
2006 Concluded	Licenciatura em Química Tecnológica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal "Controlled, “living” and syndioselective styrene polymerization using rare earth borohydrides associated with dialkylmagnesium compounds" (THESIS/DISSERTATION)	15 valores

Affiliation

Science

	Category Host institution	Employer
2019/05/01 - Current	Auxiliary Researcher (Research)	Faculdade de Ciências, Universidade de Lisboa, Portugal

2014/01/01 - 2018/12/31	Auxiliary Researcher (Research)	Universidade de Lisboa Faculdade de Ciências, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2013 - Current	Assistant Professor (University Teacher)	Universidade de Lisboa, Portugal

Positions / Appointments

	Category Host institution	Employer
2020 - Current	Member of the Executive Commission of Centro de Química Estrutural	Faculdade de Ciências, Universidade de Lisboa, Portugal
	Universidade de Lisboa Centro de Química Estrutural, Portugal
2020/07 - 2023/07	Co-Coordinator of the Technological Chemistry Master (Mestrado em Química Tecnológica)	Faculdade de Ciências, Universidade de Lisboa, Portugal
	Faculdade de Ciências, Universidade de Lisboa, Portugal
2020/07 - 2023/07	Member of the Scientific Committee of the Technological Chemistry Master (Mestrado em Química Tecnológica)	Faculdade de Ciências, Universidade de Lisboa, Portugal

Others

	Category Host institution	Employer
2021/02 - Current	Co-founder of the spin-off ´Something in Hands - Investigação Científica, Lda` (rebranded as R-nuucell)	Faculdade de Ciências, Universidade de Lisboa, Portugal

2017 - Current	Co-founder of HATICancer Proto-Company	Faculdade de Ciências, Universidade de Lisboa, Portugal

2015/11/01 - Current	Evaluator for the Fulbright Program in Portugal	Universidade de Lisboa Faculdade de Ciências, Portugal

2015/01/07 - 2015/04/07	Visiting researcher at Rutgers University, USA: Speciation of ruthenium metallodrugs by ion chromatography coupled to an ICPMS.	Rutgers The State University of New Jersey, United States

2014/06/01 - 2014/07/31	Visiting researcher at Rutgers University, USA: Speciation of ruthenium metallodrugs by ion chromatography coupled to an ICPMS.	Rutgers The State University of New Jersey, United States

2012/04/15 - 2013/12/31	Post-Doctoral Fellow, with Fundação para a Ciência e Tecnologia (FCT) grant: SFRH/BPD/80459/2011 - Polymeric Metal Complexes: New antitumoral agents with applications in controlled drug delivery	Universidade de Lisboa Faculdade de Ciências, Portugal

2011/12/01 - 2012/04/14	Post-Doctoral Fellow (Grant under the PTDC-QUI-66148-2006 Project - Synthesis of new compounds with non linear optics activity )	Universidade de Lisboa Faculdade de Ciências, Portugal

2007/10/01 - 2010/10/15	PhD student in the area of polymerization catalysis: new lanthanide and ruthenium catalysts synthesis to the polymerization of (a)polar monomers. New concepts in catalysis and new materials architectu	École nationale supérieure de chimie de Lille, France

2006/09/01 - 2007/09/30	Research in the frame of the M.Sc. thesis in Medicinal Inorganic Chemistry	Universidade de Lisboa Faculdade de Ciências, Portugal

2006/02/01 - 2006/08/31	Erasmus training period in the frame of the Technologic Chemistry Graduation, in the area of polymerization catalysis.	École nationale supérieure de chimie de Lille, France

Projects

Grant

	Designation	Funders
2023 - Current	Multifunctional Ruthenium and Selenium Drugs to Overcome Multidrug Resistance in Cancer UI/BD/154408/2023 Supervisor Universidade de Lisboa Instituto Superior Técnico, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/06/01 - Current	FCT NKFIH 2019/2020 - Development and biospeciation studies of antitumor ruthenium complexes FCT/NKFIH_2019/2020	Ongoing
2019 - Current	New ruthenium-based anticancer agents: promising therapeutic approach towards colorectal cancer SFRH/BD/139271/2018 Supervisor Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019 - Current	Development of novel iron-cyclopentadienyl compounds for cancer therapy SFRH/BD/ 139412/2018 Supervisor Faculdade de Ciências, Universidade de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019 - Current	Targeting cancer with ruthenium compounds SFRH/BD/135830/2018 Supervisor Faculdade de Ciências, Universidade de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2024/03/01 - 2026/02/28	Targeting Mutated KRAS na Principal investigator Faculdade de Ciências, Universidade de Lisboa, Portugal	Faculdade de Ciências, Universidade de Lisboa FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências Ongoing
2015 - 2019	Polymer-metal based compounds to target (non)hormone-responsive cancers: synthesis and mechanistic evaluation SFRH/BD/ 100515/2014 Supervisor Faculdade de Ciências, Universidade de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2015/01 - 2015/04	On the Mode of Action of Cyclopentadienyl Ruthenium (Macro)Metallodrugs 9f77cbc2fbfd900949a87718e3711f92 Principal investigator	Council for International Exchange of Scholars Concluded
2012 - 2013	Polymeric Metal Complexes: New antitumoral agents with applications in controlled drug delivery SFRH/BPD/80459/2011 Post-doc Fellow Centro de Ciências Moleculares e Materiais - Faculdade de Ciências, Universidade de Lisboa, Portugal	Concluded
2010 - 2012	Pos-Doc within the project “Synthesis of new compounds with non-linear optic activity” (PTDC-QUI-66148-2006) PTDC-QUI-66148-2006 Post-doc Fellow Centro de Ciências Moleculares e Materiais - Faculdade de Ciências, Universidade de Lisboa, Portugal

Contract

	Designation	Funders
2019 - Current	Polymer-metal conjugates: wide-ranging anticancer agents CEECIND/01974/2017 Principal investigator Faculdade de Ciências, Universidade de Lisboa, Portugal Universidade de Lisboa Centro de Química Estrutural, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2025/12/31	Instituto de Ciências Moleculares LA/P/0056/2020 10.54499/LA/P/0056/2020 Universidade de Coimbra Centro de Investigação em Antropologia e Saúde, Portugal Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Centro de Investigação em Química, Portugal FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal Universidade de Lisboa Faculdade de Ciências, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Coimbra, Portugal Universidade de Lisboa Centro de Química Estrutural, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/06 - 2023/05	EIC Women TechEU - project CanceRusolution (101071749) 101071749 Principal investigator R-nuucell, Portugal	European Innovation Council Ongoing
2018/09 - 2022/04/30	Fighting metastatic cancers: prime time for ruthenium PTDC/QUI-QIN/28662/2017 Principal investigator	Fundação para a Ciência e a Tecnologia Ongoing
2019 - 2022	Transnational Cooperation Programme - Portugal-Hungary, ´Development and biospeciation studies of antitumor ruthenium complexes` FCT/NKFIH 2019/2020 Researcher Faculdade de Ciências, Universidade de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018 - 2022	New diagnostic and therapeutic tools against multidrug resistant tumors - STRATAGEM (CA17104) CA17104 Researcher	Horizon 2020 Framework Programme Concluded
2019/01/01 - 2019/12/31	Centro de Química Estrutural UID/QUI/00100/2019 Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Centro de Química Estrutural, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2014/11 - 2019/11	Polymer-Ruthenium Complexes for targeted drug delivery: a new approach to fight cancer Provided by PTCRIS: 147600 Principal investigator	Fundação para a Ciência e a Tecnologia Concluded
2014 - 2018	Smart Inorganic Polymers (SIPs; CM1302) CM1302 Researcher	Horizon 2020 Framework Programme Concluded
2016 - 2016	RSC Research Fund Grant, ´Multifunctional polymer-metal complexes: an innovative approach to treat cancer` na Principal investigator	Royal Society of Chemistry Concluded
2015 - 2016	Complexes of Flavonoid`s Schiff bases: Impact of structural modification on the chelating ability and evaluation of biological and therapeutic properties FCT RD0480 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2012/03/01 - 2015/08/31	Avaliação pré-clínica de potenciais fármacos de Ruténio na terapia do cancro PTDC/QUI-QUI/118077/2010 Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal Universidade de Lisboa Faculdade de Ciências, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/03 - 2015/08	Preclinical evaluation of ruthenium potential drugs for cancer therapy Provided by PTCRIS: 118077 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2013/12/31	Projecto Estratégico - UI 536 - 2011-2012 PEst-OE/QUI/UI0536/2011 Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal Universidade de Lisboa Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01/01 - 2013/06/30	Complexos de Ruténio para aplicação anti-tumoral PTDC/QUI-QUI/101187/2008 Universidade de Lisboa Instituto Superior Técnico, Portugal Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal Universidade de Lisboa Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01 - 2013/06	Ruthenium complexes for anti-tumour application Provided by PTCRIS: 101187 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2012	Synthesis of Organometallic Molecular and Polymeric Materials with Nonlinear Optical Properties PTDC/QUI/66148/2006 Post-doc Fellow	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2023 - Current	Semi-finalists of Catapult 2023-24 2023-EHC-2592 Co-founder of the winning company, R-nuucell R-nuucell, Portugal	Ongoing
2022 - Current	COST action “European Network for diagnosis and treatment of antibiotic-resistant bacterial infections” – EURESTOP (CA21145) CA21145 Researcher	Ongoing
2021 - 2021	Innostars Awards Semifinalists n/a Co-founder of the winning company, R-nuucell R-nuucell, Portugal	European Institute of Innovation & Technology Concluded
2019 - 2021	Label-free protein quantification of cancer cells treated with new ruthenium metallodrugs EPIC-XS-0000045 Principal investigator Universidade de Lisboa Centro de Química Estrutural, Portugal	Concluded

Outputs

Publications

Book	Silva, T.J.L.; Mendes, P.J.; Morais, T.S.; Valente, A.; Robalo, M.P.; Garcia, M.H.. "RuCp" a versatile moiety: From NLO to antitumor properties. 2014.
Book chapter	Valente, Andreia; Morais, Tânia S.; Teixeira, Ricardo Jorge Gonçalves; Matos, Cristina P.; Tomaz, Ana Isabel; Garcia, Maria Helena. "Ruthenium and iron metallodrugs: new inorganic and organometallic complexes as prospective anticancer agents". In Chp 7. In Synthetic Inorganic Chemistry. Elsevier, Editor: Ewan Hamilton, 2021. Published Valente, Andreia; Morais, Tânia S.; Ricardo G. Teixeira; Cristina P. Matos; Garcia, M. Helena; Tomaz, Ana Isabel;. Corresponding author: Tomaz, Ana Isabel;. "Chapter 6 - New Inorganic Therapeutics I : : Ruthenium and iron metallodrugs: new inorganic and organometallic complexes as prospective anticancer agents". In Synthetic Inorganic Chemistry - New perspectives, edited by Ewan J. M. Hamilton. Elsevier, 2021. Published Valente, Andreia; Precker, Rafaella L. M.; Hey-Hawkins, Evamarie. Corresponding author: Valente, Andreia. "Inorganic Polymers for Potential Medicinal Applications". In Smart Inorganic Polymers, 243-276. Wiley-VCH Verlag GmbH & Co. KGaA, 2019. 10.1002/9783527819140.ch9 Valente, Andreia; Tiago J. L. Silva; Paulo J. G. Mendes; Ana Isabel Tomaz; M. Helena Garcia. Corresponding author: Valente, Andreia. "Chapter 16.5 - Polymerization of e-Caprolactone Using a Ruthenium(II) Mixed Metallocene Catalyst". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (COCELC). Royal Society of Chemistry, 2017. Matos, António; Mendes, Filipa; Valente, Andreia; Morais, Tânia; Tomaz, Ana Isabel; Zinck, Philippe; Garcia, Maria Helena; Bicho, Manuel; Marques, Fernanda. "Ruthenium-Based Anticancer Compounds: Insights into Their Cellular Targeting and Mechanism of Action". In Ruthenium Complexes – Photochemical and Biomedical Applications, 201-219. Wiley-VCH Verlag GmbH & Co. KGaA, 2017. 10.1002/9783527695225.ch10 Valente, A.; Silva, Tiago J.L.; Mendes, Paulo J. G.; Tomaz, Ana Isabel; Garcia, M. Helena; Mendes, Paulo J.; Silva, Tiago JL; Valente, Andreia. "Polymerization of e-Caprolactone Using a Ruthenium(II) Mixed Metallocene Catalyst". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (Chp. 16.5), edited by Afonso, Carlos A M; Candeias, Nuno R; Simão, Dulce Pereira; Trindade, Alexandre F; Coelho, Jaime A S; Tan, Bin; Franzen, Robert, 864-867. Cambridge, United Kingdom: Royal Society of Chemistry, 2017. Published Tiago J. L. Silva; Paulo J. Mendes; Tânia S. Morais; Valente, Andreia; M. Paula Robalo; M. Helena Garcia. "''RuCp'' a Versatile Moiety: From NLO to Antitumor Properties". In RUTHENIUM: SYNTHESIS, PHYSICOCHEMICAL PROPERTIES AND APPLICATIONS. Nova Science Publishers, 2014. Valente, Andreia; Zinck, Philippe. Corresponding author: Valente, Andreia. "Polymer-Metal Complexes (PMC) for Cancer Therapy". In Recent Research Developments in Polymer Science. Transworld Research Network, Trivandrum, India, 2012.
Conference abstract	Preto, Ana; Brás, Ana Rita; Fernandes, Pedro; Moreira, Tiago; Valente, Andreia. "New ruthenium-cyclopentadienyl agents as a new strategy to fight colorectal cancer". 2021. 10.3390/ecmc2021-11457
Conference paper	Matos, António; Marques, Fernanda; Francisco, Rita; Moreira, Tiago; Preto, Ana; Garcia, M. Helena; Valente, Andreia. "Unraveling the mode of action of new promising polymer–ruthenium conjugates". 2016. 10.1080/01913123.2016.1272669
Conference poster	Guerreiro, Ana; Valente, Andreia; Brito, Pedro. Corresponding author: Brito, Pedro. "Stability of the Macrocyclic Gd-DOTA Contrast Agent (DOTAREM) Under Different Estuarine Environmental Conditions". Paper presented in Setac Europe 33rd Annual Meeting, 2023. Ricardo G. Teixeira; Belisario, Dimas C.; Oliveira, Nuno F. B.; Sequeira, João G. N.; Romero, Isabel; Riganti, Chiara; Machuqueiro, Miguel; et al. Corresponding author: Valente, Andreia. "Targeting P-gp with Ru-cyclopentadienyl compounds: an approach to overcome cancer multidrug resistance". Paper presented in CQE Days, 2022. Fernandes, Pedro; Rita Brás, Ana; Moreira, Tiago; Valente, Andreia; Preto, Ana. "Ruthenium-based agents as promising metallodrugs to fight colorectal cancer". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020. Brás, Ana Rita; Fernandes, Pedro; Moreira, Tiago; Valente, Andreia; Preto, Ana. "Fighting colorectal cancer with ruthenium-based agents". Paper presented in CQE days, 2020. Brás, Ana R.; Fernandes, Pedro; Moreira, Tiago; Valente, Andreia; Preto, Ana. "New ruthenium-based agents target actin cytoskeleton in colorectal cancer cells". Paper presented in AACR-EACR-ASPIC Conference: Tumor Microenvironment, 2020. Brás, Ana R.; Fernandes, Pedro; Moreira, Tiago; Valente, Andreia; Ana Preto. "New ruthenium-based anticancer agents: uncovering the molecular targets towards colorectal cancer therapy". Paper presented in 6th Annual Meeting of International Society of Cancer Metabolism, 2019. Fernandes, Pedro; Brás, Ana R.; Moreira, Tiago; Valente, Andreia; Ana Preto. "New ruthenium-biotinylated anticancer agents for colorectal cancer therapy". Paper presented in V Symposium of the Doctoral Program on Molecular and Environmental Biology, 2019. Fernandes, Pedro; Brás, Ana Rita; Valente, Andreia; Preto, Ana. "New ruthenium-biotinylated anticancer agent for colorectal cancer therapy". Paper presented in V Symposium of the Doctoral Program on Molecular and Environmental Biology, 2019. Brás, Ana R.; Fernandes, Pedro; Moreira, Tiago; Valente, Andreia; Preto, Ana. "Discovering the molecular targets of new ruthenium-based anticancer agents for colorectal cancer therapy". Paper presented in 26th Porto Cancer Meeting, 2019. Brás, Ana Rita; Moreira, Tiago; Silva, Soraia; Garcia, M. Helena; Valente, Andreia; Preto, Ana. "Multifunctional polymer-ruthenium conjugates: promising therapeutic approach to colorectal cancer". Paper presented in IV Symposium of the Doctoral Program on Molecular and Environmental Biology, 2018. Brás, Ana Rita; Moreira, Tiago; Silva, Soraia; Garcia, M. Helena; Valente, Andreia; Preto, Ana. "Unraveling the molecular targets of new ruthenium compounds towards colorectal cancer therapy". Paper presented in 3rd ASPIC International Congress, 2018. Brás, Ana Rita; Moreira, Tiago; Silva, Soraia; Garcia, M. Helena; Valente, Andreia; Preto, Ana. "New ruthenium-based anticancer agents: a promising therapeutic approach to colorectal cancer". Paper presented in 25th Porto Cancer Meeting, 2018. Valente, Andreia; Moreira, Tiago; Brás, Ana Rita; Preto, Ana; Garcia, M. Helena. "Cancer targeted therapy: the next generation of metallodrugs". Paper presented in ICBIC18 ¿ International Conference on Biological Inorganic Chemistry, 2017. Mendes, Paulo J.G.; Zinck, Philippe; Valente, Andreia; Visseaux, Marc; Silva, Tiago J. L.; Garcia, M. Helena. "Dois aspectos para uma economia de catalisador de polimerizações por transferência de cadeia". Paper presented in Encontro Ciência QB, 2011.
Journal article	Podolski-Renic, Ana; Cipak Gašparovic, Ana; Valente, Andreia; Lopez, Oscar; Bormio Nunes, Julia H.; Kowol, Christian R.; Heffeter, Petra; Filipovic, Nenad R.. Corresponding author: Filipovic, Nenad R.. "Schiff bases and their metal complexes to target and overcome (multidrug) resistance in cancer". European Journal of Medicinal Chemistry (2024): 116363. http://dx.doi.org/10.1016/j.ejmech.2024.116363. 10.1016/j.ejmech.2024.116363 Teixeira, Ricardo G.; Stefanelli, Alessia; Pilon, Adhan; Warmers, Rebecca; Fontrodona, Xavier; Romero, Isabel; Costa, Paulo J.; et al. Corresponding author: Valente, Andreia. "Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands". Journal of Medicinal Chemistry (2024): http://dx.doi.org/10.1021/acs.jmedchem.3c01036. 10.1021/acs.jmedchem.3c01036 Maximiano, Inês; Henriques, Catarina; Teixeira, Ricardo G.; Marques, Fernanda; Valente, Andreia; Antunes, Alexandra M.M.. Corresponding author: Valente, Andreia. "Lead to hit ruthenium-cyclopentadienyl anticancer compounds: Cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling". Journal of Inorganic Biochemistry 251 (2024): 112436. http://dx.doi.org/10.1016/j.jinorgbio.2023.112436. 10.1016/j.jinorgbio.2023.112436 Pilon, Adhan; Avecilla, Fernando; Rácz, Bálint; Gátszegi, Gerda T.; Spengler, Gabriella; Robalo, M. Paula; Enyedy, Éva A.; Garcia, M. Helena; Valente, Andreia. Corresponding author: Valente, Andreia. "Iron(II)-cyclopentadienyl compounds are cytotoxic against colon adenocarcinoma cell lines: Ethylenebis(diphenylphosphane) vs. triphenylphosphane". Journal of Inorganic Biochemistry 249 (2023): 112386. http://dx.doi.org/10.1016/j.jinorgbio.2023.112386. 10.1016/j.jinorgbio.2023.112386 Teixeira, Ricardo G.; Mészáros, János P.; Matos, Beatriz; Côrte-Real, Leonor; Xavier, Cristina P.R.; Fontrodona, Xavier; Garcia, M. Helena; et al. Corresponding author: Valente, Andreia. "Novel family of [RuCp(N,N)(P)]+ compounds with simultaneous anticancer and antibacterial activity: Biological evaluation and solution chemistry studies". European Journal of Medicinal Chemistry 262 (2023): 115922. http://dx.doi.org/10.1016/j.ejmech.2023.115922. 10.1016/j.ejmech.2023.115922 Andres Alguacil; Franco Scalambra; Antonio Romerosa; Andreia Bento-Oliveira; Fernanda Marques; Ines Maximiano; Rodrigo F. M. de Almeida; et al. "Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives". Bioinorganic Chemistry and Applications (2023): https://doi.org/10.1155/2023/6669394. 10.1155/2023/6669394 Teixeira, Ricardo G.; Salaroglio, Iris C.; Oliveira, Nuno F. B.; Sequeira, João G. N.; Fontrodona, Xavier; Romero, Isabel; Machuqueiro, Miguel; et al. Corresponding author: Valente, Andreia. "Fighting Multidrug Resistance with Ruthenium–Cyclopentadienyl Compounds: Unveiling the Mechanism of P-gp Inhibition". Journal of Medicinal Chemistry 66 20 (2023): 14080-14094. http://dx.doi.org/10.1021/acs.jmedchem.3c01120. 10.1021/acs.jmedchem.3c01120 Brás, Ana Rita; Fernandes, Pedro; Moreira, Tiago; Morales-Sanfrutos, Julia; Sabidó, Eduard; Antunes, Alexandra M. M.; Valente, Andreia; Preto, Ana. Corresponding author: Valente, Andreia. "New Ruthenium-Cyclopentadienyl Complexes Affect Colorectal Cancer Hallmarks Showing High Therapeutic Potential". Pharmaceutics 15 6 (2023): 1731. http://dx.doi.org/10.3390/pharmaceutics15061731. 10.3390/pharmaceutics15061731 Pilon, Adhan; Avecilla, Fernando; Mohai, Miklós; Enyedy, Éva A.; Rácz, Bálint; Spengler, Gabriella; Garcia, M. Helena; Valente, Andreia. Corresponding author: Valente, Andreia. "First iron(II) organometallic compound acting as ABCB1 inhibitor". European Journal of Medicinal Chemistry (2023): 115466. http://dx.doi.org/10.1016/j.ejmech.2023.115466. 10.1016/j.ejmech.2023.115466 Stefanelli, Alessia; Teixeira, Ricardo G.; Pilon, Adhan; Warmers, Rebecca; Ott, Ingo; Kowol, Christian R.; Brozovic, Anamaria; et al. "Anticancer activity and paraptosis induction of novel bipyridine-silver(I) compounds against resistant colorectal and ovarian cancer cell lines". Cancer Research (2023): https://publons.com/wos-op/publon/62927111/. 10.1158/1538-7445.AM2023-4905 Catarina Teixeira-Guedes; Ana Rita Brás; Ricardo G. Teixeira; Valente, Andreia; Ana Preto. Corresponding author: Valente, Andreia. "Ruthenium(II)-Cyclopentadienyl-Derived Complexes as New Emerging Anti-Colorectal Cancer Drugs". Pharmaceutics 14 6 (2022): 1293-1293. https://doi.org/10.3390/pharmaceutics14061293. 10.3390/pharmaceutics14061293 Leonor Côrte-Real; Ana Rita Pinto Brás; Adhan Pilon; Nuno Mendes; Ana Sofia Ribeiro; Tiago D. Martins; José Paulo S. Farinha; et al. "Biotinylated Polymer-Ruthenium Conjugates: In Vitro and In Vivo Studies in a Triple-Negative Breast Cancer Model". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/7/1388. 10.3390/pharmaceutics14071388 Julie Meimoun; Yupin Phuphuak; Remi Miyamachi; Yong Miao; Marc Bria; Cyril Rousseau; Guilherme Nogueira; et al. "Cyclodextrins Initiated Ring-Opening Polymerization of Lactide Using 4-Dimethylaminopyridine (DMAP) as Catalyst: Study of DMAP/ß-CD Inclusion Complex and Access to New Structures". Molecules 27 3 (2022): 1083-1083. https://doi.org/10.3390/molecules27031083. 10.3390/molecules27031083 Andreia Valente; Ana Podolski-Renic; Isabella Poetsch; Nenad Filipovic; Óscar López; Iztok Turel; Petra Heffeter. "Metal- and metalloid-based compounds to target and reverse cancer multidrug resistance". Drug Resistance Updates 58 (2021): 100778-100778. https://doi.org/10.1016/j.drup.2021.100778. 10.1016/j.drup.2021.100778 Karas, Brittany F; Hotz, Jordan M; Gural, Brian M; Terez, Kristin R; DiBona, Victoria L; Côrte-Real, Leonor; Valente, Andreia; Buckley, Brian T; Cooper, Keith R. "Anticancer Activity and In Vitro to In Vivo Mechanistic Recapitulation of Novel Ruthenium-Based Metallodrugs in the Zebrafish Model". Toxicological Sciences 182 1 (2021): 29-43. http://dx.doi.org/10.1093/toxsci/kfab041. 10.1093/toxsci/kfab041 Ricardo G. Teixeira; Dimas C. Belisario; Xavier Fontrodona; Isabel Romero; Ana Isabel Tomaz; M. Helena Garcia; Chiara Riganti; Valente, Andreia. Corresponding author: Valente, Andreia. "Unprecedented collateral sensitivity for cisplatin-resistant lung cancer cells presented by new ruthenium organometallic compounds". Inorganic Chemistry Frontiers 8 (2021): 1983-1996. https://doi.org/10.1039/D0QI01344G. Published • 10.1039/D0QI01344G Nazanin Kordestani; Hadi Amiri Rudbari; Isabel Correia; Valente, Andreia; Leonor Côrte-Real; Mohammad Khairul Islam; Nicola Micale; et al. Corresponding author: Valente, Andreia. "Heteroleptic enantiopure Pd(ii)-complexes derived from halogen-substituted Schiff bases and 2-picolylamine: synthesis, experimental and computational characterization and investigation of the influence of chirality and halogen atoms on the anticancer activity". New Journal of Chemistry 45 9 (2021): 9163-9180. https://doi.org/10.1039/D1NJ01491A. 10.1039/D1NJ01491A Amiri Rudbari, Hadi; Kordestani, Nazanin; Correia, Isabel; Valente, Andreia; Côrte-Real, Leonor; Islam, Mohammad Khairul; Micale, Nicola; et al. "Heteroleptic enantiopure Pd(II)-complexes derived from halogen-substituted Schiff bases and 2-picolylamine: synthesis, experimental and computational characterization and investigation of the in¿uence of chirality and halogen atoms on the anticancer activity". New Journal of Chemistry (2021): http://dx.doi.org/10.1039/d1nj01491a. Published • 10.1039/d1nj01491a Pilon, Adhan; Brás, Ana Rita; Côrte-Real, Leonor; Avecilla, Fernando; Costa, Paulo J.; Preto, Ana; Garcia, M. Helena; Valente, Andreia. Corresponding author: Valente, Andreia. "A New Family of Iron(II)-Cyclopentadienyl Compounds Shows Strong Activity against Colorectal and Triple Negative Breast Cancer Cells". Molecules 25 7 (2020): 1592. http://dx.doi.org/10.3390/molecules25071592. 10.3390/molecules25071592 Askari, Banafshe; Rudbari, Hadi Amiri; Valente, Andreia; Bruno, Giuseppe; Micale, Nicola; Shivalingegowda, Naveen; Krishnappagowda, Lokanath Neratur. Corresponding author: Valente, Andreia. "Synthesis, Characterization and Anticancer Studies of Rh(I), Rh(III), Pd(II) and Pt(II) Complexes Bearing A Dithiooxamide Ligand". ChemistrySelect 5 2 (2020): 810-817. http://dx.doi.org/10.1002/slct.201903939. 10.1002/slct.201903939 Ricardo G. Teixeira; Fernanda Marques; M. Paula Robalo; Xavier Fontrodona; M. Helena Garcia; Simonetta Geninatti Crich; Clara Viñas; Valente, Andreia. Corresponding author: Valente, Andreia. "Ruthenium carboranyl complexes with 2,2'-bipyridine derivatives for potential bimodal therapy application". RSC Advances 10 (2020): 16266-16276. https://doi.org/10.1039/D0RA01522A. 10.1039/D0RA01522A Gano, Lurdes; Pinheiro, Teresa; Matos, António P.; Tortosa, Francisco; Jorge, Tiago F.; Gonçalves, Maria S.; Martins, Marta; et al. Corresponding author: Marques, Fernanda. "Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools". Anti-Cancer Agents in Medicinal Chemistry 19 10 (2019): 1262-1275. http://dx.doi.org/10.2174/1871520619666190318152726. 10.2174/1871520619666190318152726 Karas, Brittany F.; Côrte-Real, Leonor; Doherty, Cathleen L.; Valente, Andreia; Cooper, Keith R.; Buckley, Brian T.. "A novel screening method for transition metal-based anticancer compounds using zebrafish embryo-larval assay and inductively coupled plasma-mass spectrometry analysis". Journal of Applied Toxicology 39 8 (2019): 1173-1180. http://dx.doi.org/10.1002/jat.3802. 10.1002/jat.3802 Pilon, Adhan; Lorenzo, Julia; Rodriguez-Calado, Sergi; Adão, Pedro; Martins, Ana M.; Valente, Andreia; Alves, Luis G.. Corresponding author: Valente, Andreia. "New Cyclams and Their Copper(II) and Iron(III) Complexes: Synthesis and Potential Application as Anticancer Agents". ChemMedChem 14 7 (2019): 770-778. http://dx.doi.org/10.1002/cmdc.201800702. 10.1002/cmdc.201800702 Côrte-Real, L.; Karas, B.; Gírio, P.; Moreno, A.; Avecilla, F.; Marques, F.; Buckley, B.T.; et al. Corresponding author: Valente, Andreia. "Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand". European Journal of Medicinal Chemistry (2019): 853-863. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058617947&partnerID=MN8TOARS. 10.1016/j.ejmech.2018.12.022 Côrte-Real, L.; Karas, B.; Brás, A.R.; Pilon, A.; Avecilla, F.; Marques, F.; Preto, A.; et al. Corresponding author: Valente, Andreia. "Ruthenium-Cyclopentadienyl Bipyridine-Biotin Based Compounds: Synthesis and Biological Effect". Inorganic Chemistry (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068345812&partnerID=MN8TOARS. 10.1021/acs.inorgchem.9b00735 Moreira, T.; Francisco, R.; Comsa, E.; Duban-Deweer, S.; Labas, V.; Teixeira-Gomes, A.-P.; Combes-Soia, L.; et al. Corresponding author: Valente, Andreia. "Polymer ´ruthenium-cyclopentadienyl` conjugates - New emerging anti-cancer drugs". European Journal of Medicinal Chemistry (2019): 373-384. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062147079&partnerID=MN8TOARS. 10.1016/j.ejmech.2019.02.061 Côrte-Real, L.; Teixeira, R.G.; Gírio, P.; Comsa, E.; Moreno, A.; Nasr, R.; Baubichon-Cortay, H.; et al. Corresponding author: Valente, Andreia. "Methyl-cyclopentadienyl Ruthenium Compounds with 2,2'-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential". Inorganic Chemistry 57 8 (2018): 4629-4639. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045544510&partnerID=MN8TOARS. 10.1021/acs.inorgchem.8b00358 Teixeira, R.G.; Brás, A.R.; Côrte-Real, L.; Tatikonda, R.; Sanches, A.; Robalo, M.P.; Avecilla, F.; et al. Corresponding author: Valente, Andreia. "Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells". European Journal of Medicinal Chemistry 143 (2018): 503-514. http://www.scopus.com/inward/record.url?eid=2-s2.0-85036521878&partnerID=MN8TOARS. 10.1016/j.ejmech.2017.11.059 Vancompernolle, Tom; Valente, Andreia; Chenal, Thomas; Zinck, Philippe; Del Rosal, Iker; Maron, Laurent; Taoufik, Mostafa; Harder, Sjoerd; Gauvin, Régis M.. "Silica-Grafted Lanthanum Benzyl Species: Synthesis, Characterization, and Catalytic Applications". Organometallics 36 20 (2017): 3912-3920. http://dx.doi.org/10.1021/acs.organomet.7b00538. 10.1021/acs.organomet.7b00538 Mendes, Nuno; Tortosa, Francisco; Valente, Andreia; Marques, Fernanda; Matos, António; Morais, Tânia S.; Tomaz, Ana Isabel; Gärtner, Fátima; Garcia, M. Helena. "In Vivo Performance of a Ruthenium-cyclopentadienyl Compound in an Orthotopic Triple Negative Breast Cancer Model". Anti-Cancer Agents in Medicinal Chemistry 17 1 (2017): 126-136. http://dx.doi.org/10.2174/1871520616666160922165133. 10.2174/1871520616666160922165133 Pilon, A.; Gírio, P.; Nogueira, G.; Avecilla, F.; Adams, H.; Lorenzo, J.; Garcia, M.H.; Valente, Andreia. Corresponding author: Valente, Andreia. "New iron cyclopentadienyl complexes bearing different phosphane co-ligands: Structural factors vs. cytotoxicity". Journal of Organometallic Chemistry 852 (2017): 34-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030979386&partnerID=MN8TOARS. 10.1016/j.jorganchem.2017.10.004 Garcia, Maria Helena; Valente, Andreia; Morais, Tania S.; Tomaz, Ana Isabel. "Ruthenium new drug: paving the way for cancer therapy". Journal of Biological Inorganic Chemistry (2017): https://publons.com/wos-op/publon/15344537/. Morais, Tânia S; Valente, Andreia; Tomaz, Ana Isabel; Marques, Fernanda; Garcia, Maria Helena. "Tracking antitumor metallodrugs: promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds". Future Medicinal Chemistry 8 5 (2016): 527-544. http://dx.doi.org/10.4155/fmc.16.7. 10.4155/fmc.16.7 Nogueira, Guilherme; Favrelle, Audrey; Bria, Marc; Prates Ramalho, João P.; Mendes, Paulo J.; Valente, Andreia; Zinck, Philippe. "Adenine as an organocatalyst for the ring-opening polymerization of lactide: scope, mechanism and access to adenine-functionalized polylactide". Reaction Chemistry & Engineering 1 5 (2016): 508-520. http://dx.doi.org/10.1039/c6re00061d. 10.1039/c6re00061d Nogueira, G.; Dömötör, O.; Pilon, A.; Robalo, M.P.; Avecilla, F.; Garcia, M.H.; Enyedy, É.A.; Valente, Andreia. Corresponding author: Valente, Andreia. "¿⁶-(2-phenoxyethanol) ruthenium(II)-complexes of 2,2'-bipyridine and its derivatives: Solution speciation and kinetic behaviour". Journal of Organometallic Chemistry 820 (2016): 20-29. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982672493&partnerID=MN8TOARS. 10.1016/j.jorganchem.2016.07.017 Côrte-Real, L.; Paula Robalo, M.; Marques, F.; Nogueira, G.; Avecilla, F.; Silva, T.J.L.; Santos, F.C.; et al. Corresponding author: Valente, Andreia. "The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds". Journal of Inorganic Biochemistry 150 (2015): 148-159. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948716556&partnerID=MN8TOARS. 10.1016/j.jinorgbio.2015.06.015 Corte-Real, Leonor; Robalo, M.P.; Marques, F.; Nogueira, G.; Tomaz, A. Isabel; Garcia, M. Helena; Valente, Andreia. "Influence of structural factors in the modulation of cytotoxic activity". Medicinal Chemistry 05 10 (2015): 96-96. http://dx.doi.org/10.4172/2161-0444.c1.016. Published • 10.4172/2161-0444.c1.016 Valente, Andreia; Stoclet, Gregory; Bonnet, Fanny; Mortreux, André; Visseaux, Marc; Zinck, Philippe. "Isoprene-Styrene Chain Shuttling Copolymerization Mediated by a Lanthanide Half-Sandwich Complex and a Lanthanidocene: Straightforward Access to a New Type of Thermoplastic Elastomers". Angewandte Chemie International Edition 53 18 (2014): 4638-4641. http://dx.doi.org/10.1002/anie.201311057. 10.1002/anie.201311057 Valente, Andreia; Garcia, M.. Corresponding author: Valente, Andreia. "Syntheses of Macromolecular Ruthenium Compounds: A New Approach for the Search of Anticancer Drugs". Inorganics 2 1 (2014): 96-114. http://dx.doi.org/10.3390/inorganics2010096. 10.3390/inorganics2010096 Côrte-Real, Leonor; Mendes, Filipa; Coimbra, Joana; Morais, Tânia S.; Tomaz, Ana Isabel; Valente, Andreia; Garcia, M. Helena; et al. "Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes". JBIC Journal of Biological Inorganic Chemistry 19 6 (2014): 853-867. http://dx.doi.org/10.1007/s00775-014-1120-y. 10.1007/s00775-014-1120-y Valente, Andreia; Santos, A.M.; Côrte-Real, L.; Robalo, M.P.; Moreno, V.; Font-Bardia, M.; Calvet, T.; Lorenzo, J.; Garcia, M.H.. "New iron(II) cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leukemia cancer cells". Journal of Organometallic Chemistry 756 (2014): 52-60. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894195747&partnerID=MN8TOARS. 10.1016/j.jorganchem.2014.01.027 Valente, Andreia; Mortreux, André; Visseaux, Marc; Zinck, Philippe. "Coordinative Chain Transfer Polymerization". Chemical Reviews 113 5 (2013): 3836-3857. http://dx.doi.org/10.1021/cr300289z. 10.1021/cr300289z Matos, C.P.; Valente, Andreia; Marques, F.; Adão, P.; Paula Robalo, M.; De Almeida, R.F.M.; Pessoa, J.C.; et al. "New polydentate Ru(III)-Salan complexes: Synthesis, characterization, anti-tumour activity and interaction with human serum proteins". Inorganica Chimica Acta 394 (2013): 616-626. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868218698&partnerID=MN8TOARS. 10.1016/j.ica.2012.09.026 Valente, Andreia; Garcia, M.H.; Marques, F.; Miao, Y.; Rousseau, C.; Zinck, P.. Corresponding author: Valente, Andreia. "First polymer "ruthenium-cyclopentadienyl" complex as potential anticancer agent". Journal of Inorganic Biochemistry 127 (2013): 79-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884576725&partnerID=MN8TOARS. 10.1016/j.jinorgbio.2013.07.002 Valente, Andreia; Royer, S.; Narendra, M.; Silva, T.J.L.; Mendes, P.J.G.; Robalo, M.P.; Abreu, M.; Heck, J.; Garcia, M.H.. "Synthesis of new Fe(II) and Ru(II) ¿ ⁵ -monocyclopentadienyl compounds showing significant second order NLO properties". Journal of Organometallic Chemistry 736 (2013): 42-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876167870&partnerID=MN8TOARS. 10.1016/j.jorganchem.2013.02.028 Valente, Andreia; Zinck, Philippe; Mortreux, André; Visseaux, Marc; Mendes, Paulo J.G.; Silva, Tiago J.L.; Garcia, M. Helena. "Polymerization of ¿-caprolactone using ruthenium(II) mixed metallocene catalysts and isopropyl alcohol: Living character and mechanistic study". Journal of Molecular Catalysis A: Chemical 346 1-2 (2011): 102-110. http://dx.doi.org/10.1016/j.molcata.2011.06.015. 10.1016/j.molcata.2011.06.015 Valente, Andreia; Zinck, P.; Mortreux, A.; Bria, M.; Visseaux, M.. "Half-lanthanocene/dialkylmagnesium-mediated coordinative chain transfer copolymerization of styrene and hexene". Journal of Polymer Science, Part A: Polymer Chemistry 49 17 (2011): 3778-3782. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960878625&partnerID=MN8TOARS. 10.1002/pola.24816 Valente, Andreia; Zinck, P.; Mortreux, A.; Visseaux, M.. "Borohydrido rare earth based coordinative chain transfer copolymerization: A convenient tool for tuning the microstructure of isoprene/styrene copolymers". Journal of Polymer Science, Part A: Polymer Chemistry 49 7 (2011): 1615-1620. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952147062&partnerID=MN8TOARS. 10.1002/pola.24585 Moreno, V.; Font-Bardia, M.; Calvet, T.; Lorenzo, J.; Avilés, F.X.; Garcia, M.H.; Morais, T.S.; Valente, Andreia; Robalo, M.P.. "DNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexes containing heteroaromatic ligands". Journal of Inorganic Biochemistry 105 2 (2011): 241-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649615202&partnerID=MN8TOARS. 10.1016/j.jinorgbio.2010.10.009 Garcia, M.H.; Valente, Andreia; Florindo, P.; Morais, T.S.; Piedade, M.F.M.; Duarte, M.T.; Moreno, V.; Avilés, F.X.; Loreno, J.. "New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy". Inorganica Chimica Acta 363 14 (2010): 3765-3775. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957982339&partnerID=MN8TOARS. 10.1016/j.ica.2010.05.034 Zinck, P.; Valente, Andreia; Bonnet, F.; Violante, A.; Mortreux, A.; Visseaux, M.; Ilinca, S.; Duchateau, R.; Roussel, P.. "Reversible coordinative chain transfer polymerization of styrene by rare earth borohydrides, chlorides/dialkylmagnesium systems". Journal of Polymer Science, Part A: Polymer Chemistry 48 4 (2010): 802-814. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955249881&partnerID=MN8TOARS. 10.1002/pola.23828 Valente, Andreia; Zinck, P.; Vitorino, M.J.; Mortreux, A.; Visseaux, M.. "Rare earths/main group metal alkyls catalytic systems for the 1,4-trans stereoselective coordinative chain transfer polymerization of isoprene". Journal of Polymer Science, Part A: Polymer Chemistry 48 21 (2010): 4640-4647. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649574820&partnerID=MN8TOARS. 10.1002/pola.24225 Valente, Andreia; Zinck, Philippe; Mortreux, André; Visseaux, Marc. "Catalytic Chain Transfer (co-)Polymerization: Unprecedented Polyisoprene CCG and a New Concept to Tune the Composition of a Statistical Copolymer". Macromolecular Rapid Communications 30 7 (2009): 528-531. http://dx.doi.org/10.1002/marc.200800734. 10.1002/marc.200800734 Zinck, Philippe; Valente, Andreia; Terrier, Michaël; Mortreux, André; Visseaux, Marc. "Half-lanthanidocenes catalysts via the “borohydride/alkyl” route: A simple approach of ligand screening for the controlled polymerization of styrene". Comptes Rendus Chimie 11 6-7 (2008): 595-602. http://dx.doi.org/10.1016/j.crci.2007.12.006. 10.1016/j.crci.2007.12.006 Zinck, Philippe; Valente, Andreia; Mortreux, André; Visseaux, Marc. "In situ generated half-lanthanidocene based catalysts for the controlled oligomerisation of styrene: Selectivity, block copolymerisation and chain transfer". Polymer 48 16 (2007): 4609-4614. http://dx.doi.org/10.1016/j.polymer.2007.06.014. 10.1016/j.polymer.2007.06.014 Zinck, Philippe; Terrier, Michaël; Mortreux, André; Valente, Andreia; Visseaux, Marc. "A New Family of Styrene/Diene Rubbers". Macromolecular Chemistry and Physics 208 9 (2007): 973-978. http://dx.doi.org/10.1002/macp.200700055. 10.1002/macp.200700055
Online resource	Côrte-Real, L.; Mendes, Filipa; Coimbra, Joana; Morais, Tânia S; Tomaz, Ana Isabel; Valente, Andreia; Garcia, Maria Helena; Santos, Isabel; Bicho, Manuel. Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes. 2014. https://globalmedicaldiscovery.com/?s=Anticancer+activity+of+structurally+related+ruthenium%28II%29+cyclopentadienyl+complexes.
Thesis / Dissertation	Valente, Andreia. "Lanthanide based coordinative chain transfer polymerization for architecture control in (co)polymers and ruthenium catalysed ring-opening polymerization: two aspects of atom economy in polymerization catalysis". PhD, Université de Lille, 2010. Valente, Andreia. "Ruthenium metallocene syntheses and evaluation of their potentialities as anticancer agents". Master, Faculdade de Ciências, Universidade de Lisboa, 2007.

Intellectual property

Patent	Maria Helena Garcia; Valente, Andreia; Tânia S. Morais; Ana Isabel Tomaz. 2016. "Macromolecular Transition Metal Complexes For Treatment Of Cancer And Process For Their Preparation". Granted/Issued
Provisional application for patent	2023. "Use Of An Organometallic Ruthenium Compound For The Prevention And/Or Treatment Of Diseases And/ Or Conditions Related To Cancer In An Individual.". Disclosed

Other

Other output

A new ruthenium-cyclopentadienyl compound as a promising cancer MDR reversing agent. Oral communication given at CQE Days 2023.. 2023. Valente, Andreia; Ricardo G. Teixeira; Maximiano, Inês; Oliveira, N. F. B.; Sequeira, João G. N.; Antunes A; Machuqueiro, Miguel.
"Ruténio - o elemento que não para de nos surpreender!" In “Os Elementos em Ciências - Uma viagem pela Tabela Periódica. (Editors: A. Mourato, A. Paula Carvalho, F. Leitão, T. Pamplona), 2020, Faculdade de Ciências da Universidade de Lisboa.. 2020. Valente, Andreia; Morais, Tânia S; Garcia, M. Helena.

Spin-off company

2021. R-nuucell. Development of anticancer drugs. http://www.r-nuucell.com/.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2024/03/08	\|Invited Seminar\| From test tube to the clinic: the search for a new ruthenium anticancer agent, A. Valente Lecture on the on the Post-Graduated Course – Cancer Therapy: from basic research to clinic. 8th Edition.	Post-Graduated Course – Cancer Therapy: from basic research to clinic. 8th Edition (by Zoom, Portugal)
2024/03/06	\|Invited Seminar\| Andreia Valente, "Ruthenium-cyclopentadienyl complexes as chemosensitizers in cisplatin-resistant cancers", presented at Workshop on "Breakthroughs of non-platinum anticancer metallopharmaceuticals"	Workshop on "Breakthroughs of non-platinum anticancer metallopharmaceuticals" (Lisboa, Portugal)
2024/01/05	\|Invited Seminar\| From test tube to the clinic: the search for a new ruthenium anticancer agent, A. Valente lecture in the frame of the UC "Quimioterapia com compostos de alguns elementos não essenciais" for the M.Sc. in Pharmaceutical Sciences and Graduation in Biochemistry from Universidade Lusófona	(by Zoom, Portugal)
2023/05/04	\|Invited Seminar\| From test tube to the clinic: the search for a new ruthenium anticancer agent, A. Valente Lecture on the on the Post-Graduated Course – Cancer Therapy: from basic research to clinic. 7th Edition.	Department of Biology, Universidade do Minho (Braga, Portugal)
2023/05	\|Invited Seminar\| Targeting aggressive cancers with ruthenium compounds, A. Valente Lecture on the on the Post-Graduated Course – Cancer Therapy: from basic research to clinic. 6th Edition. 20-31 May 2022, Department of Biology, Universidade do Minho	Department of Biology, Universidade do Minho (Braga, Portugal)
2023/04/24	\|Invited Seminar\| From test tube to the clinic: the search for a new ruthenium anticancer agent, A. Valente Lecture in the frame of the UC “Biotecnologia Molecular” from the M.Sc. in Molecular Biology and Genetics from FCUL	Faculdade de Ciências, Universidade de Lisboa (Lisboa, Portugal)
2023/01/01	\|Invited Seminar\| From test tube to the clinic: the search for a new ruthenium anticancer agent, A. Valente lecture in the frame of the UC "Quimioterapia com compostos de alguns elementos não essenciais" for the M.Sc. in Pharmaceutical Sciences and Graduation in Biochemistry from Universidade Lusófona	Universidade Lusófona (Lisboa, Portugal)
2022/09/28	\|Invited\| Specific Targeting for Colorectal Cancer Harboring KRAS Mutation Using a New Ruthenium-Based Agent, A. R. Brás, A. Lopes, N. Mendes, P. Fernandes, T. Moreira, F. Gärtner, A. Valente, A. Preto*	6th Cancer World Congress (Lisboa, Portugal)
2022/07/15	Iron-cyclopentadienyl compounds with phosphane and N-based ligands show strong activity against a broad panel of human cancer cell lines - Adhan Pilon*, M. Helena Garcia, Andreia Valente	2nd Chem & Biochem Students Meeting Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa (Lisboa, Portugal)
2022/03/29	Novel ruthenium-cyclopentadienyl agents targeting KRAS mutated colorectal cancer - Brás AR*, Fernandes P, Moreira T, Valente A, Preto A.	13th Inorganic & Bioinorganic Chemistry Conference (Aveiro, Portugal)
2022/03/10	Overcoming cancer multidrug resistance with ruthenium cyclopentadienyl compounds - Andreia Valente*	8th Latin American Symposium on Coordination and Organometallic Chemistry
2021/12/17	\|Invited Seminar\| From test tube to the clinic: the search for a new ruthenium anticancer agent, A. Valente Lecture in the frame of the UC "Quimioterapia com compostos de alguns elementos não essenciais" for the M.Sc. in Pharmaceutical Sciences and Graduation in Biochemistry from Universidade Lusófona	Universidade Lusófona (Lisboa, Portugal)
2021/01/19	\|Invited Seminar\| From test tube to the clinic: the search for a new ruthenium anticancer agent, Andreia Valente Lecture in the frame of Inorganic Medicinal Chemistry for the M.Sc. in Pharmaceutical Sciences and Graduation in Biochemistry from Universidade Lusófona	Universidade Lusófona (Lisboa, Portugal)
2021	Overcoming cisplatin resistance in lung cancer using Ru(II) compounds - Ricardo G. Teixeira*, Ana Isabel Tomaz, M. Helena Garcia, Andreia Valente	3rd CQE Days Spring meeting (Online Meeting, Portugal)
2021	\|Invited\| Ruthenium cyclopentadienyl compounds as prospective anticancer metallodrugs - A. Valente*	Virtual Conference on Organometallic Chemistry EuCOMC XXIV (Madrid, Spain)
2020/11/01	Iron-cyclopentadienyl compounds with nitrile-based ligands show strong activity against a broad panel of human cancer cell lines - Adhan Pilon*, M. Helena Garcia, Andreia Valente	6th International Electronic Conference on Medicinal Chemistry, electronic conference
2020/05/22	\|Invited Seminar\| Targeted cancer therapy using ruthenium compounds, Andreia Valente Lecture on the “Sessões CBIOS 2019/2020”	Universidade Lusófona (Lisboa, Portugal)
2020/05	\|Invited Seminar\| Targeted cancer therapy using ruthenium compounds, Andreia Valente Lecture on the Post-Graduated Course – “Bionanoparticles: challenges and therapeutic opportunities”. 4th to 15rd of May 2020	Department of Biology, Universidade do Minho (Braga, Portugal)
2020/02/27	Ruthenium-cyclopentadienyl bipyridine-biotin based compound: P-gp inhibition and activity against resistant cancer cells - Andreia Valente*, Leonor Côrte-Real, M. Helena Garcia, Marie Ehrlichova, Radka Vaclavikova	STRATAGEM CA17104 Annual Conference, 3rd meeting and 4th WGs meeting (Belgrade, Serbia)
2020/01/30	Chemical and Biological Applications of Cyclam-Based Copper(II) Complexes - Luis G. Alves*, Adhan Pilon, Andreia Valente, Ana M. Martins	III International Workshop on Chemistry of Group 11 Elements (Caparica, Portugal)
2020/01/16	Fighting Breast Cancer with Ruthenium-based Metallodrugs endowed with Tumor-targeting Vectors - Leonor Côrte-Real*, Ana Rita Brás, Ana Preto, M. Helena Garcia, Andreia Valente	13º Encontro Nacional de Química Orgânica/6º Encontro Nacional de Química Terapêutica (Aveiro, Portugal)
2019/12/04	\|Invited\| Strategies for targeted cancer therapy using ruthenium-cyclopentadienyl complexes - A. Valente*, Leonor Côrte-Real, Ana Rita Brás, M. Helena Garcia, Ana Preto	3rd International Caparica Christmas Congress on Translational Chemistry (Caparica, Portugal)
2019/09/05	\|Invited\| New Ruthenium-Cyclopentadienyl Complexes Bearing Biotinylated (Macro)Ligands: Targeting Strategies To Fight Metastatic Breast Cancer - Leonor Côrte-Real*, Ana Rita Brás, Ana Preto, M. Helena Garcia, Andreia Valente	6th Young Medicinal Chemist Symposium (EFMC-YMCS 2019), 5-6 September 2019 (Athens, Greece)
2019/07/26	\|Invited\| Fighting metastatic cancers with ruthenium cyclopentadienyl compounds - Andreia Valente*	XXVI Encontro Nacional da Sociedade Portuguesa de Química (Porto, Portugal)
2019/06/24	\|Invited\| Targeting cancer with selective and potent ruthenium compounds - Andreia Valente*	6th World Congress on Natural Product & Synthetic Chemistry (Synthetic Chemistry 2019) (New York, USA)
2019/06/24	\|Invited\| Progress on the design of metal-based drugs for cancer therapy - M. Helena Gracia*, Tânia S. Morais, Andreia Valente, Ana Isabel Tomaz	6th World Congress on Natural Product & Synthetic Chemistry (Synthetic Chemistry 2019), (New York, USA)
2019/05/31	Novel ruthenium complexes as potent anticancer agents: strategies for targeted therapy - Andreia Valente*	CQE Days Spring Meeting (Lisboa, Portugal)
2019/05	\|Invited Seminar\| Strategies for targeted cancer therapy using ruthenium complexes, A. Valente Lecture on the on the Post-Graduated Course – Cancer Therapy: from basic research to clinic. 5th Edition. 20-31 May 2019	Department of Biology, Universidade do Minho (Braga, Portugal)
2019/01/30	New ruthenium metallodrugs against cancer multidrug resistance - A. Valente*	2nd MC Meeting and 1st WG1-WG4 meeting of CA17104 – STRATAGEM – New diagnostic and therapeutic tools against multidrug resistant tumors (Turin, Italy)
2018	On the mode of action of anticancer ruthenium-polymer conjugates - Andreia Valente,* Ana Rita Brás, M. Helena Garcia, Ana Preto	International Conference on Coordination Chemistry (Sendai, Japan)
2018	Novel ruthenium methylcyclopentadienyl complexes bearing bipyridine based ligands with strong anticancer activity - M. Helena Garcia,* Ricardo G. Teixeira, Leonor Côrte-Real, Patrícia Gírio, Andreia Valente	International Conference on Coordination Chemistry (Sendai, Japan)
2018	Ruthenium Cyclopentadienyl Compounds: Cytotoxic Agents Against Resistant Cancer Cells - Andreia Valente*, Leonor Côrte-Real, Helena Garcia	12th Inorganic and Bioinorganic Chemistry Conference (Porto, Portugal)
2018	Ruthenium drugs: born to cure - Andreia Valente*	Ciência 2018 (Centro de Congressos de Lisboa, Portugal)
2018	Novel ruthenium cyclopentadienyl complexes bearing bipyridine based (macro)ligands with strong activity towards cancer cells - Ricardo G. Teixeira, Ana Rita Brás, Leonor Côrte-Real, Rajendhraprasad Tatikonda, M. Helena Garcia, Matti Haukka, Ana Preto, Andreia Valente*	4th European Conference on Smart Inorganic Polymers (Zagreb, Croatia)
2018	Carboxyphenyl chlorins as platforms for photodynamic therapy of cancer: Synthesis and photophysical studies - José Almeida, Andreia Leite, Luís Cunha-Silva, Maria Rangel, Baltazar de Castro, Andreia Valente, Adhan Pilon, Ana F. R. Cerqueira, Augusto C. Tomé, Ana M. G. Silva*	4th European Conference on Smart Inorganic Polymers (Zagreb, Croatia)
2017/12/05	\|Invited\| ABC proteins: targets for ruthenium-cyclopentadienyl anticancer compounds? - Andreia Valente*, Patrícia Gírio, Leonor-Côrte-Real, Ricardo Teixeira, Pierre Falson, M. Helena Garcia	II International Caparica Christmas Congress on Translational Chemistry (Caparica, Portugal)
2017/08/08	\|Invited\| Unprecedented polymer-metal vesicles as efficient anticancer agents - M. Helena Garcia*, L. Côrte-Real, A. P. Soto, C. Rodrigues, A. R. Fernandes, A. Valente	SILQCOM 2017 (Puerto Iguazú, Misiones, Argentina)
2017/05/20	\|Invited\| Ruthenium compounds as metallodrug candidates for cancer therapy - Ana Isabel Tomaz*, Andreia Valente, Tânia S. Morais, Fernanda Marques, M. Helena Garcia,	BIT’s 10th annual world cancer congress (Barcelone, Spain)
2017/05	\|Invited Seminar\| From test tube to the clinic: the search for an anticancer agent for triple negative breast cancer, A. Valente Lecture on the on the Post-Graduated Course – Cancer Therapy: from basic research to clinic. 15-26th May 2017	Department of Biology, Universidade do Minho (Braga, Portugal)
2017	Novel ruthenium-cyclopentadienyl complexes as potential candidates to surmount multidrug resistance in cancer - Côrte-Real L.*, Gírio P., Moreno A., Garcia M. H., Falson P., Valente A.	UL Chemsitry PhD Meeting (2ECQUL) (Lisboa, Portugal)
2017	Adenine end-capped polylactide: Synthesis via adenine organocatalyzed ring-opening polymerization of lactide And application in cancer therapy - Guilherme Nogueira, Audrey Favrelle, Marc Bria, João P. Prates Ramalho, Paulo J. Mendes, Andreia Valente, Philippe Zinck*	6th International Conference on Biobased and Biodegradable Polymers (BIOPOL-2017) (Mons, Belgium)
2017	Ruthenium-cyclopentadienyl’ moiety: a versatile scaffold for the design of anticancer agents. - Andreia Valente*, Adhan Pilon, Anabela Sanches, Leonor Côrte-Real, Ricardo Teixeira, M. Helena Garcia	SILQCOM 2017 (Puerto Iguazú, Misiones, Argentina)
2017	New self-assembled polymer-metal compounds: highly efficient anticancer vesicles - Leonor Côrte-Real*, Alejandro P. Soto, Ana S. Viana, Alexandra R. Fernandes, M. Helena Garcia, Andreia Valente	Chem&BioChem postgraduate students meeting (Lisboa, Portugal)
2016/11/22	\|Invited\| Targeting cancer with new multifunctional metallodrugs - Andreia Valente*, Leonor Côrte-Real, Tiago Moreira, Ana Preto, M. Helena Garcia	World Congress on Cancer Research and Therapy (Miami, United States)
2016/11/22	\|Invited\| Ruthenium new drugs: a promising future for cancer therapy? - M. Helena Garcia*, Andreia Valente, Tânia S. Morais, Isabel Tomaz	World Congress on Cancer Research and Therapy (Miami, United States)
2016/07/04	\|Invited Seminar\| From test tube to the clinic: the search for an anticancer agent for triple negative breast cancer, A. Valente	Lodz University of Technology (Lodz, Poland)
2016/06/18	\|Invited\| Polymer-metal conjugates: versatile scaffolds for the synthesis of new antitumor drugs - Andreia Valente*, Leonor Côrte-Real, Guilherme Nogueira, Anabela Sanches, Fernanda Marques, Francisco Tortosa, Fátima Gärtner, Nuno Mendes, M. Helena Garcia	European Chemistry Congress (Rome, Italy)
2016/06/18	\|Invited\| Ruthenium Organometallic compounds as promising anti- metastatic drugs for breast cancer chemotherapy - M. Helena Garcia*, Andreia Valente, Tânia S. Morais, Fernanda Marques	European Chemistry Congress (Rome, Italy)
2016/05	\|Invited Seminar\| Targeted cancer nanotherapy using metal-polymer conjugates, A. Valente Lecture on the Post-graduated course – “Bionanoparticles: challenges and therapeutic opportunities”, 23rd May to 3rd June 2016	Departamento de Biologia, Universidade do Minho (Braga, Portugal)
2016/04/27	\|Invited Seminar\| Ruthenium-polymer conjugates: new promising anticancer agents, A. Valente, Conferences Cycle from Centro de Química de Évora, Ph.D. Program in Chemistry and M.Sc. in Chemistry	Universidade de Évora (Évora, Portugal)
2016	Strategical synthesis of porphyrinic carboxylate ligands as promising photosensitizers for photodynamic therapy of cancer - J. Almeida*, A. Leite, A. M. N. Silva, L. Cunha-Silva, B. de Castro, M. Rangel, A. Pilon, A. Valente, A. M. G. Silva	Third European Conference on Smart Inorganic Polymers (Porto, Portugal)
2016	Self-assembled polymer-ruthenium micelles: new promising anticancer agents - Leonor Côrte-Real*, Alejandro P. Soto, Ana S. Viana, M. Helena Garcia, Andreia Valente	Third European Conference on Smart Inorganic Polymers (Porto, Portugal)
2016	Self-assembled polymer-metal micelles: new promising anticancer agents - Leonor Côrte-Real*; M. Helena Garcia; Ana S. Viana; Andreia Valente	5PYChem/EyChem (Guimarães, Portugal)
2015/12/09	\|Invited\| Multifunctional polymer-ruthenium cyclopentadienyl complexes: new promising anticancer agents - A. Valente*, M.H. Garcia, A. Pilon, A.P. Matos, F. Mendes, M.A.F. Faustino, N. Mendes, F. Gärtner, A. Preto, R. Francisco, F. Marques	I International Caparica Christmas Congress on Translational Chemistry (Caparica, Portugal)
2015/11/04	\|Invited\| Ruthenium drugs for cancer therapy: small structural changes, different in vivo performances - M. Helena Garcia*, Tânia S. Morais, A. Isabel Tomaz, Fernanda Marques, Andreia Valente	4th International Conference on Medicinal Chemistry & Computer Aided Drug Designing (Atlanta, United States)
2015/11/03	\|Invited\| On the mode of action of new promising anticancer agents: multifunctional polymer-ruthenium conjugates - A. Valente*, M.H. Garcia, A. Pilon, A.P. Matos, F. Tortosa, N. Mendes, F. Gärtner, A. Preto, R. Francisco, B. T. Buckley, F. Marques	4th International Conference on Medicinal Chemistry & Computer Aided Drug Designing (Atlanta, United States)
2015/06/17	\|Invited Seminar\| Ruthenium drugs: born to kill, A. Valente Chemforum	Instituto Superior Técnico (Lisboa, Portugal)
2015/05	\|Invited Seminar\| Medicinal Inorganic Chemistry: Metal-polymer conjugates for cancer therapy, Andreia Valente Lecture on the Post-Graduated Course – Cancer Therapy: from basic research to clinic. 8-19 June 2015	Department of Biology, Universidade do Minho (Braga, Portugal)
2015	Multifunctional polymer-ruthenium conjugates: new promising anticancer agents - Andreia Valente*, L. Côrte-Real, A.P. Matos, M. H. Garcia, F. Marques	2nd European Conference on Smart Inorganic Polymers, (Upsalla, Sweden)
2015	Access to a new type of thermoplastic elastomer via rare earth catalysts mediated chain shuttling polymerization - Andreia Valente, Thibaut Pinalie, Fanny Bonnet, Grégory Stoclet, Jean-Marc Lefèbvre, Marc Visseaux, André Mortreux, Philippe Zinck*	Eufen 4, Fourth joined meeting of COST Action CM1006: European f-Element Chemistry (Lisboa, Portugal)
2014/12/08	\|Invited\| Polymer ´ruthenium-cyclopentadienyl` conjugates: a new approach to fight cancer - Andreia Valente*, M. Helena Garcia, Leonor Côrte-Real, Guilherme Nogueira, Philippe Zinck, António Matos, Fernanda Marques,	3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing (San Francisco, United States)
2014/12/08	\|Invited\| Tracking antitumor drugs: ruthenium(II) cyclopentadienyl complexes as promising agents - M. Helena Garcia*, Tânia Morais, Andreia Valente, Fernanda Marques	3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing (San Francisco, United States)
2014/11/24	\|Invited Seminar\| Polymer ‘ruthenium-cyclopentadienyl’ conjugates: a new approach to fight cancer, Andreia Valente	École Nationale Supérieure de Chimie de Lille (Lille, France)
2014/11/17	\|Invited\| Finding Homes for all of the Orphan Assays - Brian Buckley*, Andreia Valente, Ill Yang, Min Liu, Kyle Buckley, Frances Acevedo Mariani, Stephanie Marco, Elizabeth McCandlish	Eastern Analytical Symposium (Somerset NJ, United States)
2014/07/10	Access to amorphous thermoplastic elastomers of tunable transition temperatures via chain shuttling copolymerization (Invited) - Andreia Valente, Grégory Stoclet, Fanny Bonnet, André Mortreux, Marc Visseaux, Philippe Zinck*	IUPAC World Polymer Congress (Chiang Mai, Thailand)
2014/05/23	\|Invited Seminar\| Metal-polymer conjugates for cancer therapy, Andreia Valente Post-graduated course Bionanotechnology for diagnosis and therapy of cancer”, 19-30 May 2014, CBMA	Department of Biology, Universidade do Minho (Braga, Portugal)
2014/01/29	\|Invited Seminar\| New polymer ‘ruthenium-cyclopentadienyl’ complexes for drug delivery in cancer therapy, Andreia Valente CCMM Seminars	Faculdade de Ciências, Universidade de Lisboa (Lisboa, Portugal)
2014	New ruthenium-polymer conjugates for drug delivery in cancer therapy - Guilherme Nogueira*, Andreia Valente	2º Encontro Nacional de Estudantes de Química (Covilhã, Portugal)
2014	\|Invited Seminar\| New polymer-ruthenium conjugates for drug delivery in cancer chemotherapy, Andreia Valente Lecture on Inorganic Biochemistry from the 2nd academic year of the Biochemistry Course	Faculdade de Ciências, Universidade de Lisboa (Lisboa, Portugal)
2013/10/16	New polymeric “ruthenium-cyclopentadienyl” complexes for drug delivery in cancer therapy (Invited) - Andreia Valente*, M. Helena Garcia, Fernanda Marques, Philippe Zinck	2nd International Conference on Medicinal Chemistry & Computer Aided Drug Designing (Las Vegas, United States)
2013	New polymer-ruthenium conjugates for targeted drug delivery in cancer chemotherapy (Flash Presentation) - Andreia Valente*, M. H. Garcia, F. Marques, P. Zinck	Nanoparticles for early Diagnostics of inflammatory diseases (Lisboa, Portugal)
2012	Polydentate Octhaedric Ru Complexes: Synthesis, Characterization, Anti-Tumour Activity and Interaction with Human Serum Proteins (Flash Presentation) - Matos, C.P.*; Valente, A.; Marques, F.; Adão, P.; Robalo, M.P.; Almeida, R.F.M.; Costa Pessoa, J.; Garcia, M.H.; Tomaz, A.I.	XXV International Conference on Organometallic Chemistry (Lisboa, Portugal)
2012	New polydentate Ru(III)-Salan complexes: synthesis, characterization, antitumour activity and interaction with human serum proteins - Cristina P. Matos, Andreia Valente, Fernanda Marques, Pedro Adão, Rodrigo F. M. Almeida, João Costa Pessoa, M. Helena Garcia, Ana Isabel Tomaz*	International Symposia on Metal Complexes – ISMEC (Lisboa, Portugal)
2012	Coordinative chain transfer polymerization: recent advances and a new paradigm using rare earth catalysts - A. Valente, P. Zinck*, A. Mortreux, M. Visseaux	Eufen 1, First joined meeting of COST Action CM1006: European f-Element Chemistry (Tarragone, Spain)
2011	Dois aspectos para uma economia de catalisador em polimerizações por transferência de cadeia - Andreia Valente*	Ciência QB - 1º Encontro dos Alunos de Doutoramento do DQB (Lisboa, Portugal)
2009	Polymérisation coordinative par transfert de chaîne: vers de nouvelles applications - Andreia Valente*	Journée des jeunes chercheurs en polymère (Lille, France)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023 - Current	Multifunctional Ruthenium and Selenium Drugs to Overcome Multidrug Resistance in Cancer Supervisor of Catarina Henriques	Doutoramento em Química (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2023 - Current	Investigação sobre fontes alternativas de melanina marinha aplicadas à energia solar térmica. Estudo de pigmentos e nanomaterais em fluídos de transferência de calor Co-supervisor of Rafael Marçal Almeida	Doutoramento em Química Tecnológica (PhD) Faculdade de Ciências, Universidade de Lisboa, Portugal
2023 - Current	\|Final Graduation Project\| Síntese e caracterização de novos complexos de prata(I) para a terapia do cancro Supervisor of Daniela Lino	Química Faculdade de Ciências, Universidade de Lisboa, Portugal
2022 - Current	Uncover the mechanism of action of new FeCp compounds in colorectal cancer cells Co-supervisor of Ana Paula Passos da Silva	Mestrado em Biologia Celular e Molecular (Master) Universidade do Porto Faculdade de Ciências, Portugal
2019/03/01 - Current	New ruthenium-based anticancer agents: promising therapeutic approach towards colorectal cancer Co-supervisor of Ana Rita Brás	Biologia Molecular e Ambiental (PhD) Universidade do Minho, Portugal
2019/01/01 - Current	Targeting cancer with ruthenium compounds Supervisor of Ricardo Teixeira	Química (PhD) Faculdade de Ciências, Universidade de Lisboa, Portugal
2019/01/01 - Current	New multifunctional drug delivery systems for cancer therapy via innovative polymerization strategies Supervisor of Adhan Pilon	Química (PhD) Faculdade de Ciências, Universidade de Lisboa, Portugal
2021 - 2023	Estudo da estabilidade de agentes de contraste do gadolínio em diferentes condições ambientais estuarinas Co-supervisor of Ana Guerreiro	Mestrado em Química Tecnológica (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2020 - 2023	Integração de requisitos GMP’s e ISSO 17025 para Qualificação de equipamentos e Validação de Sistemas na Indústria Farmacêutica no ISQ Co-supervisor of Catarina Santos	Mestrado em Química Tecnológica (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2021 - 2022	Pre-clinical studies against colorectal cancer for a prospective ruthenium anticancer metallodrug Supervisor of Ana Lopes	Mestrado em Bioquímica (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2021 - 2022	Avaliação da interação de potenciais metalofármacos de ruténio com proteínas do sangue por ressonância magnética nuclear (final graduation project) Co-supervisor of Bruno Severino	Licenciatura em Química Tecnológica (Degree) Faculdade de Ciências, Universidade de Lisboa, Portugal
2020/09/01 - 2021	On the mode of action of prospective ruthenium anticancer metallodrugs and their metabolic and plasma stability Supervisor of Inês Maximiano	Bioquímica (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2020 - 2021	Potenciais metalofármacos de ruténio: estudos de formulação para administração intravenosa (final graduation project) Supervisor	Licenciatura em Química Tecnológica (Degree) Faculdade de Ciências, Universidade de Lisboa, Portugal
2020 - 2021	Síntese e caracterização de complexos bimetálicos com potencial aplicação como agentes anti-tumorais (final graduation project) Supervisor of Neuza Salgado	Licenciatura em Química (Degree) Faculdade de Ciências, Universidade de Lisboa, Portugal
2019/11/01 - 2020/09/01	Síntese e caracterização de complexos de Molibdénio como sistemas de libertação de CO para o tratamento do cancro Co-supervisor	Química (Degree) Faculdade de Ciências, Universidade de Lisboa, Portugal
2019/11/01 - 2020/07/20	Novos complexos de ruténio contendo benzonitrilos derivatizados como potenciais agentes anticancerígenos Supervisor of Jorge Valentim	Química (Degree) Faculdade de Ciências, Universidade de Lisboa, Portugal
2019/03/01 - 2019/07/24	Síntese de novos complexos de metais endógenos com potencial anticancerígeno (Final Graduation Project) Supervisor of Beatriz Moreno	Química (Degree) Faculdade de Ciências, Universidade de Lisboa, Portugal
2019/01/01 - 2019/07/23	Desenvolvimento de novos complexos de ruténio com derivados da curcumina como potenciais agentes anticancerígenos (Final Graduation Project) Supervisor of Rita Soares	Química Aplicada (Degree) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/02/01 - 2019/06/04	Polymer-metal based compounds to target (non)hormone-responsive cancers: synthesis and mechanistic evaluation Supervisor of Leonor Côrte-Real	Química (PhD) Faculdade de Ciências, Universidade de Lisboa, Portugal
2018/02/01 - 2018/07/23	Síntese, caracterização e avaliação biológica de novos complexos de ruténio derivatizados com glucose para terapia dirigida do cancro (Final Graduation Project) Supervisor of Bernardo Henriques	Química (Degree) Faculdade de Ciências, Universidade de Lisboa, Portugal
2016/09/01 - 2017/07/05	The role of ABC proteins in the mechanism of action of promising ruthenium anticancer agents Supervisor of Patrícia Gírio	Química (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2016 - 2017	Synthesis of new 3D-?5-carboranyl ruthenium complexes incorporating polymeric ligands towards combinatory therapy of cancer Supervisor of Ricardo Teixeira	Química (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2016 - 2017	Unraveling the molecular targets of new ruthenium-based anticancer drugs Co-supervisor of Ana Rita Brás	Genética Molecular (Master) Universidade do Minho, Portugal
2015 - 2017	Development of new metalodrugs: new ruthenium complexes bearing macromolecular ligands as antitumor agents Co-supervisor of Maria Inês Pereira	Química (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2015 - 2016	A importância de moléculas azotadas nas estruturas poliméricas de novos complexos de ferro macromoleculares como agentes anticancerígenos” Supervisor of Adhan Pilon	Química Tecnológica (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2015 - 2016	New metal-based micelles as targeted anticancer agents Co-supervisor of Bebiana Pinto	Química (Master) Universidade de Évora, Portugal
2015 - 2016	Unraveling the molecular targets of new ruthenium-based anticancer drugs Co-supervisor of Tiago Moreira	Genética Molecular (Master) Universidade do Minho, Portugal
2015 - 2016	Development of new ruthenium compounds as potential drugs for the treatment of hypophysis adenomas Supervisor of Anabela Sanches	Química (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2015 - 2016	New iron cyclopentadienyl complexes as anticancer agents: a structure-activity study (Final Graduation Project) Supervisor of Patrícia Gírio	Química (Degree) Faculdade de Ciências, Universidade de Lisboa, Portugal
2015 - 2016	Diretos ao Alvo: Virtual Screening de potenciais fármacos usando uma biblioteca de compostos com interesse farmacêutico (Final Graduation Project) Co-supervisor of Carla Antunes	Química Tecnológica (Degree) Faculdade de Ciências, Universidade de Lisboa, Portugal
2014 - 2015	Functionalization of biocompatible polyesters with substrates of biological interest via organocatalyzed ring-opening polymerization: application in cancer therapy Supervisor of Guilherme Nogueira	Química Tecnológica (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2013/02/01 - 2014/07/19	Development of potential metallodrugs for cancer therapy (Final Graduation Project) Supervisor of Ricardo Teixeira	Química (Degree) Faculdade de Ciências, Universidade de Lisboa, Portugal
2013/01/01 - 2014/07/17	New ruthenium-polymer complexes syntheses in view of photodynamic therapy in melanoma cancer (Final Graduation Project) Supervisor of Adhan Pilon	Química Tecnológica (Degree) Faculdade de Ciências, Universidade de Lisboa, Portugal
2012/09/01 - 2013/07/23	New ruthenium-polymer complexes syntheses for controlled drug delivery in cancer therapy (Final Graduation Project) - Awarded with a with a Amadeu Dias Scholarship Supervisor of Guilherme Nogueira	Química Tecnológica (Degree) Faculdade de Ciências, Universidade de Lisboa, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023/03/24 - Current	Jornadas da Química Tecnológica 2023, subjacente a tema, emprego: a versatilidade dos “tecnológicos” Contou com a presença de atuais e antigos alunos, docentes, empregadores e mesa redonda. (2023)	Faculdade de Ciências, Universidade de Lisboa, Portugal
2016/09/12 - 2016/09/14	3rd European Conference on Smart Inorganic Polymers, Porto, Portugal (2016/09/12 - 2016/09/14) Conference (Member of the Organising Committee)
2015/11/02 - 2015/11/04	4th International Conference on Medicinal Chemistry & Computer Aided Drug Designing, Atlanta, USA (2015/11/02 - 2015/11/04) Congress (Member of the Organising Committee)
2014/12/08 - 2014/12/10	3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing, San Francisco, USA (2014/12/08 - 2014/12/10) Congress (Member of the Organising Committee)

Event participation

	Activity description Type of event	Event name Institution / Organization
2022/09/16 - Current	Talk to ~30 Professors from Indian Universities organized by the IST international Office in the frame of an Erasmus+ Project - Enprendia Enhancing Woman Entrepreneurship in India (http://enprendia.eu/). Objective: Testimony of a FCUL spin-off (R-nuucell) about the process of moving from research to the market.	Tec Labs – Centro de inovação, Portugal
2022/09/15 - Current	Talk to students from ISEG MBA (accompanied by the Startup Lisboa). Objective: to share R-nuucell’s entrepreneurial journey, as well as R-nuucell’s journey in transferring its knowledge to the market.	Tec Labs – Centro de inovação, Portugal
2022/07/20 - Current	Women TechEU cocktail sunset – Participation in the round table. Objective: join and celebrate the national entrepreneurial community leading with technological-based companies and contribute to the national mobilization and participation at the European Commission prizes dedicated to women entrepreneurs. After the round table there was a networking moment. Where: Hub Criativo do Beato, Lisboa, Portugal	Hub Criativo do Beato, Portugal
2019/10/30 - Current	\|Outreach Activities\| CIÊNCIAS Research Day 2019 – Presentation of two posters	CIÊNCIAS Research Day 2019 Faculdade de Ciências, Universidade de Lisboa, Portugal
2017/05/04 - Current	Participation at the round table "Alumni vs. students", http://jornadasqt2017.campus.ciencias.ulisboa.pt/node/4	Jornadas da Química Tecnológica Faculdade de Ciências, Universidade de Lisboa, Portugal
2015/11/24 - Current	Speech within the scientific path of a former Technological Chemistry student	Dia da Química Tecnológica Faculdade de Ciências, Universidade de Lisboa, Portugal
2015 - Current	\| Outreach Activities \| Participation in several activities that promote interaction between the community and FCUL: Dia Aberto DQB, FCUL (2015-2021); Ser Cientista, FCUL (year 2015); Open Lab Days to secondary school students (since 2011 to 2021); SPEED DATING com os cientistas at FCUL (2019)	Faculdade de Ciências, Universidade de Lisboa, Portugal
2020 - 2021	\| Outreach Activity \| Participation in the European Researchers' Night with the video "Podem os metalofármacos ser uma boa aposta para a terapia do cancro?" - Festival de Curtas - Química para Todos@ULisboa; Vídeo disponível em: https://www.youtube.com/watch?v=Dea38ODk6T4&feature=emb_logo (NEI2020, NEI2021)	European Researchers' Night 2020 and 2021

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2023/02/16	«Corrosão em materiais usados no armazenamento de energia aplicado à tecnologia solar térmica de concentração President of the jury	Mafalda Susano Gil (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2023/02/06	Substituição de substâncias perigosas na indústria: análise de alternativas para retardadores de chama halogenados President of the jury	Anita Pacheco Jensen (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2023/02/02	Phenol and Formaldehyde Free Offset Printing Ink Resins President of the jury	Filipa Marques Bernardes (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2023/02/02	Otimização do processo produtivo de uma tetraciclina de segunda geração na CIPAN President of the jury	Aléxia Sofia Granados Serra (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2022/12/20	Caracterização por calorimetria diferencial de varrimento de polímeros e misturas poliméricas para aplicações marinhas. Estudos para a biodegradabilidade. President of the jury	André Filipe Batista Mendes (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2022/12/06	Caracterização térmica e reológica de poliolefinas fabricadas no Complexo Industrial de Sines da REPSOL POLÍMEROS President of the jury	Gil Vasco da Silva Gonçalves (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2022/10/13	Avaliação das Necessidades de Substituição de Substâncias Perigosas na Indústria Nacional e Análise de Alternativas President of the jury	Carina Isabel Cardoso Silva (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2022/09/30	Organometallic Nucleosides: Synthesis of Platinum and Palladium complexes bearing NHeterocyclic carbenes based on nucleosides and their anticancer activity - Ph.D. in Molecular Biosciences - Thesis Committee Main Examiner (Thesis) Main arguer	Maria Inês Paiva da Silva Leitão (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2022/01/07	Identificação de oportunidades de melhoria na polimerização e nas unidades de suporte do processo de produção de fibras acrílicas na SGL Composites, S.A. President of the jury	Miguel Ângelo da Silva Alves (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2021/04/08	Compatibility study of rosin esters with metallocene catalysed polyolefins in the resin industry President of the jury	Joana Filipa Almeida Casimiro (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2020/12/21	Avaliação da pasta solúvel da Caima para produção de fibras Lyocell President of the jury	Ana Marta do Rosário Antunes (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal
2020/01/13	Anticancer Organoruthenium(II) Glycoconjugates: Tricks or Treats? (Thesis) Main arguer	Sofia Alexandra da Conceição de Carvalho Milheiro (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/11/05	Nuevos complejos de coordinación con el ligando dmoPTA: Avances en la capacidade antiproliferativa (Thesis) Main arguer	Elisabet Zenaida Mendoza Nozeman (PhD) Universidad de La Laguna, Spain
2015/12/10	Development of folate-targeted liposomes for rheumatoid arthritis therapy (Thesis) Main arguer	Eugénia Sofia da Costa Nogueira (PhD) Universidade do Minho, Portugal
2015/11/26	Synthesis of new metal complexes and evaluation of their potential as anticancer agents (Thesis) Main arguer	Ana Sofia Assis (Master) Faculdade de Ciências, Universidade de Lisboa, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2021 - Current	44448 Catálise - 1st cycle in Technological Chemistry (homogeneous catalysis block)	Química Tecnológica (Licenciatura)	Faculdade de Ciências, Universidade de Lisboa, Portugal
2017 - Current	Technological Innovation Laboratories / Laboratórios de Inovação Tecnológica (2015/16; 2017/18; 2021/22; 2022/23)	Química Tecnológica (Mestrado)	Faculdade de Ciências, Universidade de Lisboa, Portugal
2019 - 2022	44446 Técnicas de Caracterização (old UC 44430) - 1st cycle in Chemistry and Technological Chemistry (NMR block responsible)	Química + Química Tecnológica (Licenciatura)	Faculdade de Ciências, Universidade de Lisboa, Portugal
2018 - 2020	44425 Química Inorgânica Complementar - 1st cycle in Chemistry	Química (Licenciatura)	Faculdade de Ciências, Universidade de Lisboa, Portugal
2016 - 2019	Molecular Spectroscopy / Espectroscopia Molecular	Química + Química Tecnológica (Licenciatura)	Faculdade de Ciências, Universidade de Lisboa, Portugal
2016 - 2017	Spectroscopy / Espectroscopia	Química (Licenciatura)	Faculdade de Ciências, Universidade de Lisboa, Portugal
2011 - 2015	Chemistry / Química Geral	Ciências da Engenharia - Engenharia Biomédica e Biofísica (Licenciatura)	Faculdade de Ciências, Universidade de Lisboa, Portugal
2010 - 2015	Biochemistry (introductory) / Bioquímica	Ciências da Saúde (Licenciatura)	Faculdade de Ciências, Universidade de Lisboa, Portugal
2007 - 2009	Chemical Engineering / "Génie Chimique"	(Licence)	Université de Lille, France

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2022 - Current	Accompanying Commission: Nuno Filipe Baltazar Maia Costa de Oliveira - PhD student in Chemistry, Faculdade de Ciências, Universidade de Lisboa. Thesis entitled “Development of computational methods to study and help revert tumor MDR”. Other	Faculdade de Ciências, Universidade de Lisboa, Portugal
2018 - Current	Accompanying commission of João Miguel Franco Machado, PhD student in Chemistry, Faculdade de Ciências, Universidade de Lisboa. Thesis entitled ´Novos conjugados ruténio-péptido para a terapia seletiva do cancro da mama metastático`	Faculdade de Ciências, Universidade de Lisboa, Portugal
2015/01/01 - Current	Evaluator for the Fulbright Program in Portugal in the Chemistry area. Evaluator		Fulbright Portugal
2023 - 2023	Revision of one project for the Agencia Nacional de Investigación e Innovación (ANII), the main public funding agency in Paraguay.
2022 - 2022	Revision of one project for the Czech Science Foundation (www.gacr.cz/en), the main public funding agency in the Czech Republic supporting all areas of basic research. Evaluator		Grantová agentura Ceské republiky
2020 - 2020	PhD student in Chemistry (CATSUS program) from Instituto Superior Técnico, Universidade de Lisboa. Thesis entitled ´Syntheses and reactivity of titanium and zirconium complexes supported by salan- and salen ligands`. Evaluator	Universidade de Lisboa Instituto Superior Técnico, Portugal
2020 - 2020	Scientific Expert at the evaluation process of Generic Call 2020 from the Agence Nationale de la Recherche (ANR). https://anr.fr/fr/detail/call/appel-a-projets-generique-2020/ Evaluator		Agence nationale de la recherche
2019 - 2019	International Expert Reviewer for the FONDECYT Regular 2019 grant competition, an initiative of the Chilean National Science and Technology Commission (CONICYT - Chile) - https://www.conicyt.cl/fondecyt/2018/07/26/concurso-regular-fondecyt-2019/ Evaluator		CONICYT – National Commission for Science and Technology

Journal scientific committee

	Journal title (ISSN)	Publisher
2019 - Current	Chemical Science (2041-6539)	Royal Society of Chemistry
2019 - Current	Journal of Inorganic Biochemistry (0162-0134)	Elsevier
2018 - Current	Inorganica Chimica Acta (0020-1693)	Elsevier
2018 - Current	Chemistry - An Asian Journal (1861-471X)	Wiley-VCH GmbH
2016 - Current	Inorganic Chemistry (0020-1669)	American Chemical Society
2015 - Current	European Journal of Medicinal Chemistry (0223-5234)	Elsevier

Mentoring / Tutoring

	Topic	Student name
2023/05 - 2023/08	Summer project entitled: “Potential of some metal-based compounds as anti-cancer agents”	Téo Khalifa, 2nd year of French Engineering in Chemistry (corresponding to the 4nd year of higher ed
2023/04 - 2023/07	Erasmus Summer Project entitled “Development of cupper complexes for cancer therapy”	Damien Krasnowolski, 2nd year student from the University and Technological Institute of Béthune
2023/02 - 2023/07	PhD student in Chemical And Pharmaceutical Sciences And Biotechnology from UNICAM - University of Camerino doing a 6-months research period at my laboratory	Daphne Romani
2022/06 - 2022/07	Erasmus Summer Project entitled “Synthesis and formulation studies of new prospective metallodrugs considering in vivo administration”	Eléna Oliveira, 1st-year student from the M.Sc. in Chemistry and Chemical Engineering, École Nationa
2022/04 - 2022/07	2nd year student from the University and Technological Institute of Béthune, Erasmus Summer Project entitled “Development of iron-polymer conjugates for cancer therapy”	Camille Gelle
2021/09 - 2021/12	Short-term scientific mission in the frame of PhD thesis in Advanced Chemistry entitled “New biologically active polyheterometallic complexes containing dmoPTA (3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane)”	Andrés Alguacil Alarcón, PhD Student, University of Almería
2021/10 - 2021/11	Short-term scientific mission in the frame of his PhD thesis in Química Sustentável entitled “Synthesis of ruthenium(II)-porfirin/chlorin conjugates”	José de Almeida, PhD student, Faculdade de Ciências da Universidade do Porto (FCUP)
2019/07 - 2021/06	PosDoc hired in the frame of A. Valente’s project “Fighting metastatic cancers: prime time for ruthenium” (PTDC/QUI-QIN/28662/2017)	Leonor Côrte-Real, PhD
2020/09 - 2020/10	Third year student – Graduate Engineering Programme from École Nationale Superieure de Chimie de Lille, Erasmus Summer Project entitled “New ruthenium compounds as prospective metallodrugs”	Amélie da Silva
2019/05 - 2019/08	Undergraduate student from the Chemistry course from École Nationale Superieure de Chimie de Lille, Erasmus Summer Project “The use of biocompatible polymers as drug delivery systems in cancer therapy”	Marion Bovolenta
2018/06 - 2018/07	Undergraduate student from the Chemistry course from École Nationale Superieure de Chimie de Lille, Erasmus Summer Project “Biocompatible polymers for application in cancer therapy”	Giulia Ottavi
2018/01 - 2018/04	Short Term Scientific Mission on the scope of the COST action CM1302 entitled “Study of the stability and antiproliferative properties of the bimetallic complexes [RuCp(PPh3)2-µ-dmoPTA-1¿P:2k2N,N’-MCl2] (M = Co, Zn)”.	Zenaida Mendoza Nozeman, PhD student, Universidad de La Laguna
2015/07 - 2015/10	Summer Internship from Erasmus + Program, undergraduate student from Faculty of Chemistry, Lodz University of Technology. Project titled “Synthesis of biocompatible (co)polymers for application in cancer therapy”	Maciej Mackowiak
2014/06 - 2014/07	Summer undergraduate student from University of Puerto Rico, in the frame of the RiSE (Research in Science and Engineering) programme at Rutgers University, USA	Frances Azevedo

Other jury / evaluation

	Activity description	Institution / Organization
2021/04/02 - Current	Evaluation Committee - Diana Díaz García, Ph.D. in Inorganic Chemistry. Thesis title: Diseño y caracterización de nanomateriales de nueva generación con aplicaciones avanzadas en química médica.	Universidad Rey Juan Carlos, Spain
2020/07/10 - Current	Final project for the B.Sc. degree in Chemistry. Project title: “Desenvolvimento de novos complexos organometálicos de cobalto-ciclopentadienilo com potencial aplicação como agentes antitumorais” - Project Main Examiner	Faculdade de Ciências, Universidade de Lisboa, Portugal
2019/07/23 - Current	Final project for the B.Sc. degree in Chemistry. Project title: “O papel de proteínas séricas na distribuição e modo de ação de metalofármacos com potencial atividade anti-tumoral” - Project Main Examiner	Faculdade de Ciências, Universidade de Lisboa, Portugal
2017/07/25 - Current	Final project for the B.Sc. degree in Chemistry. Project title: “Síntese de novos complexos de cobre com ligandos tipo tiosemicarbazona com potencial anticancerígeno” - Project Main Examiner	Faculdade de Ciências, Universidade de Lisboa, Portugal

Distinctions

Award

2023	R-nuucell was semi-finalist of EIT Catapult 2023-24 European Institute of Innovation & Technology, Hungary
2022	R-nuucell was awarded by the European Innovation Council Women TechEU Innitiative European Innovation Council, Belgium
2022	ASPIC Patients' Advocacy Award to the poster: Brás AR, Fernandes P, Moreira T, Valente A, Preto A, “Targeting KRAS mutated colorectal cancers with new ruthenium-based drugs” at 5th ASPIC International Congress, 30th June – 1st July 2022, Porto, Portuga Associação Portuguesa de Investigação em Cancro, Portugal
2021	Innostars Awards Semi-Finalist with the spin-off R-nuucell EIT Health, Germany
2021	R-nuucell won the Call INNOV-ID from Portugal Ventures, entering their portfolio.
2020	Best oral communication - "Fighting Breast Cancer with Ruthenium-based Metallodrugs endowed with Tumor-targeting Vectors" (authors: Leonor Côrte-Real,* Ana Rita Brás, Ana Preto, M. Helena Garcia, Andreia Valente) Universidade de Aveiro, Portugal
2019	Best Oral Communication Prize: Andreia Valente, “Novel ruthenium complexes as potent anticancer agents: strategies for targeted therapy”
2017	Best Poster Prize: P. Girio, A. Moreno, M. H. Garcia, P. Falson, A. Valente, “ABC proteins: targets for ruthenium-cyclopentadienyl anticancer metallodrugs?” V Encontro Nacional De Estudantes De Química, 07-10 April 2017, Coimbra, Portugal
2017	Best oral Communication, L. Côrte-Real, A.P. Soto, A.S. Viana, A.R. Fernandes, M.H. Garcia, A. Valente, “New self-assembled polymer-metal compounds: highly efficient anticancer vesicles”, Chem&BioChem postgraduate students meeting, 9th Feb 2017, Lisbon
2017	RSC Travel for the ICBIC18 – International Conference on Biological Inorganic Chemistry, July, 31st – August, 4th – 2017 - Florianópolis – Brazil. Royal Society of Chemistry, United Kingdom
2016	Royal Society of Chemistry Research Fund Grant, “Multifunctional polymer-metal complexes: an innovative approach to treat cancer” Royal Society of Chemistry, United Kingdom
2015	1st position in the ScienceIN2Business 2015 call (M. Helena Garcia, Andreia Valente, Ana Isabel Tomaz, Tânia Morais, “RuPharma”)
2015	Young Investigator Award at the 2nd European Conference on Smart Inorganic Polymers, Upsalla, Sweden
2014	Fulbright grant for Portuguese Scholars and Researchers, Jan – March 2015
2013	Best poster prize, M. Helena Garcia, Tânia S. Morais, Ana Isabel Tomaz, Andreia Valente, Fernanda Marques, "Cyclopentadienyl ruthenium (macro)metallodrugs: large spectrum antitumor agents”
2010	Travel Grant to the Third European Chemical Society Congress (EuCheMS, Nürnberg, Germany, 2010)

Other distinction

2022	R-nuucell was the only Portuguese company selected to participate at Healthcare EIC Investor Day, 29 & 30 November, Lisboa, organized by .European Innovation Council and CUF Hospitals
2015	Biographical profile in the Marquis Who’s Who in the World 2016 - 33rd Edition (Classic); ISBN: 978-0-8379-1156-4.
2013	Media Citation - “Cancro: Portuguesas vencem prémio mundial nos EUA"
2013	Media Citation - Portuguese news
2007	Invitation to the cover of the Journal Macromolecular Chemistry and Physics (2007, 208, 973-978) with the paper entitled “A New family of Styrene/Diene Rubbers”