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Identification

Personal identification

Full name
Sara Gomes Moreira

Citation names

  • Gomes, Sara

Author identifiers

Ciência ID
9F1C-A97D-C3CE
ORCID iD
0000-0002-9086-2303
Google Scholar ID
H6JZcxoAAAAJ&hl
Researcher Id
C-6534-2016
Scopus Author Id
55671067100

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Biochemical Research Methods

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2014 - 2019
Concluded
 Doctoral Programme in Molecular and Cellular Biotechnology Applied to Health Sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Targeting p53-impaired tumors: impact of new small molecules targeting p73 and mutant p53." (THESIS/DISSERTATION)
2013
Concluded
 Mestrado em Bioquímica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Studying p53 family proteins: search for small-molecule modulators" (THESIS/DISSERTATION)
 17
2011
Concluded
 Licenciatura em Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Ionotropic P2X7 receptor favours osteogenic differentiation and membrane cell blebbing dynamics of human bone marrow stromal cells" (THESIS/DISSERTATION)
 15
Affiliation

Others

Category
Host institution 		Employer
2014/01/01 - 2019/09/16 PhD student on the Microbial Biotechnology research group coordinated by Professor Lucília Saraiva. REQUIMTE LAQV Porto, Portugal
2012/07/01 - 2013/10/18 MSc student on the Microbial Biotechnology research group coordinated by Professor Lucília Saraiva. Universidade do Porto Faculdade de Farmácia, Portugal
2010/09/01 - 2011/09/01 Undergraduate student on the research group coordinated by Professor Paulo Correia-de-Sá. Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Outputs

Publications

Journal article
  1. Sara Gomes; Liliana Raimundo; Joana Soares; Joana B. Loureiro; Mariana Leão; Helena Ramos; Madalena N. Monteiro; et al. "New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma". Cancer Letters 446 (2019): 90-102. https://doi.org/10.1016%2Fj.canlet.2019.01.014.
    10.1016/j.canlet.2019.01.014
  2. Lopes EA; Gomes S; Saraiva L; Santos M. "Small Molecules Targeting Mutant P53: A Promising Approach For Cancer Treatment.". Current medicinal chemistry (2018): http://europepmc.org/abstract/med/30444195.
    10.2174/0929867325666181116124308
  3. Moreira, Sara. "The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding". International Journal of Molecular Sciences (2018): http://www.mdpi.com/1422-0067/19/4/1184.
    10.3390/ijms19041184
  4. Facioni, M.S.; Soares, J.; Adinolfi, B.; Gomes, S.; Raimundo, L.; Contini, A.; Ruffoni, B.; et al. "Biological effects of saponin fractions from Astragalus verrucosus in tumor and non-tumor human cells". Natural Product Communications 13 9 (2018): 1105-1110. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053230833&partnerID=MN8TOARS.
  5. Soares J; Espadinha M; Raimundo L; Ramos H; Gomes AS; Gomes S; Loureiro JB; et al. "DIMP53-1: A novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties.". (2017): http://europepmc.org/abstract/med/28296148.
    10.1002/1878-0261.12051
  6. Gomes S; Leão M; Raimundo L; Ramos H; Soares J; Saraiva L. "p53 family interactions and yeast: together in anticancer therapy.". (2016): http://europepmc.org/abstract/med/26891980.
    10.1016/j.drudis.2016.02.007
  7. Soares J; Raimundo L; Pereira NA; Monteiro Â; Gomes S; Bessa C; Pereira C; et al. "Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule.". (2016): http://europepmc.org/abstract/med/26735173.
    10.18632/oncotarget.6775
  8. Daniela Pereira; Raquel T. Lima; Andreia Palmeira; Hugo Seca; Joana Soares; Sara Gomes; Liliana Raimundo; et al. "Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold". Arabian Journal of Chemistry (2016): http://www.sciencedirect.com/science/article/pii/S1878535216300399.
    http://dx.doi.org/10.1016/j.arabjc.2016.04.015
  9. Pereira, D.; Lima, R.T.; Palmeira, A.; Seca, H.; Soares, J.; Gomes, S.; Raimundo, L.; et al. "Design and synthesis of new inhibitors of p53-MDM2 interaction with a chalcone scaffold". Arabian Journal of Chemistry (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85014742778&partnerID=MN8TOARS.
    10.1016/j.arabjc.2016.04.015
  10. Leão M; Soares J; Gomes S; Raimundo L; Ramos H; Bessa C; Queiroz G; et al. "Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction.". (2015): http://europepmc.org/abstract/med/26475964.
    10.1016/j.lfs.2015.10.015
  11. Leão, M.; Gomes, S.; Bessa, C.; Soares, J.; Raimundo, L.; Monti, P.; Fronza, G.; Pereira, C.; Saraiva, L.. "Studying p53 family proteins in yeast: Induction of autophagic cell death and modulation by interactors and small molecules". Experimental Cell Research 330 1 (2015): 164-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-84917677533&partnerID=MN8TOARS.
    10.1016/j.yexcr.2014.09.028
  12. Leão, M.; Gomes, S.; Pedraza-Chaverri, J.; MacHado, N.; Sousa, E.; Pinto, M.; Inga, A.; Pereira, C.; Saraiva, L.. "a-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach". Journal of Natural Products 76 4 (2013): 774-778. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876902872&partnerID=MN8TOARS.
    10.1021/np400049j
  13. Bessa, C.; Pereira, C.; Leão, M.; Maciel, C.; Gomes, S.; Gonçalves, J.; Corte-Real, M.; Costa, V.; Saraiva, L.. "Using yeast to uncover the regulation of protein kinase Cd by ceramide". FEMS Yeast Research 13 7 (2013): 700-705. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886089759&partnerID=MN8TOARS.
    10.1111/1567-1364.12069
  14. Leão, M.; Gomes, S.; Soares, J.; Bessa, C.; MacIel, C.; Ciribilli, Y.; Pereira, C.; Inga, A.; Saraiva, L.. "Novel simplified yeast-based assays of regulators of p53-MDMX interaction and p53 transcriptional activity". FEBS Journal 280 24 (2013): 6498-6507. http://www.scopus.com/inward/record.url?eid=2-s2.0-84889663663&partnerID=MN8TOARS.
    10.1111/febs.12552

Intellectual property

Patent
  1. Gomes, Sara. 2019. "Tryptophanol-derived oxazoloisoindolinones: small-molecule p53 activators.".
    Granted/Issued
Distinctions

Award

2019 MED.IDEAS award