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Catarina Mendes Morais. Concluiu o(a) Mestrado em Bioquímica em 2010 pelo(a) Universidade de Coimbra Faculdade de Ciencias e Tecnologia e Licenciatura em Bioquímica em 2009 pelo(a) Universidade de Coimbra Faculdade de Ciencias e Tecnologia. É Ph.D. student no(a) Universidade de Coimbra Centro de Neurociências e Biologia Celular e Research grant (BIM 6.1) in the project BrainHealth 2020 (CENTRO-01-0145-FEDER-000008) no(a) Universidade de Coimbra Centro de Neurociências e Biologia Celular. Publicou 16 artigos em revistas especializadas. Possui 2 capítulo(s) de livros. Organizou 1 evento(s). Participou em 8 evento(s).
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Identification

Personal identification

Full name
Catarina Mendes Morais

Citation names

  • Morais, Catarina

Author identifiers

Ciência ID
A016-C917-5096
ORCID iD
0000-0002-4762-0798

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
French Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
Education
Degree Classification
2019/06/29
Concluded
 Decisões Financeiras Estratégicas (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Faculdade de Economia, Portugal
2010
Concluded
 Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Toxicity in vitro of two lupane-type triterpenoid derivatives. Effects on synthetic membrane, bacterial and mitochondrial models" (THESIS/DISSERTATION)
2009
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
Affiliation

Others

Category
Host institution 		Employer
2012/03/01 - Current Ph.D. student Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/06/19 - 2021/08/31 Research grant (BIM 6.1) in the project BrainHealth 2020 (CENTRO-01-0145-FEDER-000008) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/12/09 - 2014/02/13 Course in Laboratorial Animal Science FELASA B - 40 h Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/10/01 - 2012/02/28 Research grant (BI) project PTDC/QUI-BIQ/103001/2008, “Interaction of Lipoplexes with Cellular Membranes: a Biophysical Approach to Gene Delivery”. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Outputs

Publications

Book chapter
  1. Morais, Catarina. "Recent Trends in Nanotechnology Toward CNS Diseases". 2016.
    10.1016/bs.irn.2016.05.002
  2. Jurado, Amália S; Morais, Catarina; Santos, Sandra M; Videira, Romeu A; Pedroso de L. M. C.. "The role of membrane lipids in a toxicological context: lessons from microorganism adaptive responses". In A Toxicological/Pharmacological Approach to Chemico-Biological Interactions at a Membrane Level, edited by Jurado, Amália S. 2012.
Journal article
  1. Cardoso, Ana M; Morais, Catarina M; Sousa, Madalena; Rebelo, Olinda; Tão, Hermínio; Barbosa, Marcos; Pedroso de Lima, Maria C; Jurado, Amália S. "MiR-200c-based metabolic modulation in glioblastoma cells as a strategy to overcome tumor chemoresistance". Human Molecular Genetics (2021): http://dx.doi.org/10.1093/hmg/ddab193.
    10.1093/hmg/ddab193
  2. Amorim, Ricardo; Simões, Inês C. M.; Veloso, Caroline; Carvalho, Adriana; Simões, Rui F.; Pereira, Francisco B.; Thiel, Theresa; et al. "Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells". Nutrients 13 5 (2021): 1723. http://dx.doi.org/10.3390/nu13051723.
    10.3390/nu13051723
  3. Cardoso, Ana M; Morais, Catarina M; Pena, Frederico; Marante, Tânia; Cunha, Pedro P; Jurado, Amália S; Pedroso de Lima, Maria C. "Differentiation of glioblastoma stem cells promoted by miR-128 or miR-302a overexpression enhances senescence-associated cytotoxicity of axitinib". Human Molecular Genetics 30 3-4 (2021): 160-171. http://dx.doi.org/10.1093/hmg/ddab011.
    10.1093/hmg/ddab011
  4. Cardoso, Ana M; Morais, Catarina M; Rebelo, Olinda; Tão, Hermínio; Barbosa, Marcos; Pedroso de Lima, Maria C; Jurado, Amália S. "Downregulation of long non-protein coding RNA MVIH impairs glioblastoma cell proliferation and invasion through an miR-302a-dependent mechanism". Human Molecular Genetics 30 1 (2021): 46-64. http://dx.doi.org/10.1093/hmg/ddab009.
    10.1093/hmg/ddab009
  5. Morais, Catarina M.; Cardoso, Ana M.; Aguiar, Luísa; Vale, Nuno; Nóbrega, Clévio; Zuzarte, Mónica; Gomes, Paula; Pedroso de Lima, Maria C.; Jurado, Amália S.. "Lauroylated Histidine-Enriched S413-PV Peptide as an Efficient Gene Silencing Mediator in Cancer Cells". Pharmaceutical Research 37 10 (2020): http://dx.doi.org/10.1007/s11095-020-02904-x.
    10.1007/s11095-020-02904-x
  6. Morais, Catarina M; Cunha, Pedro P; Melo, Tânia; Cardoso, Ana M; Domingues, Pedro; Domingues, M Rosário; Pedroso de Lima, Maria C; Jurado, Amália S. "Glucosylceramide synthase silencing combined with the receptor tyrosine kinase inhibitor axitinib as a new multimodal strategy for glioblastoma". Human Molecular Genetics 28 21 (2019): 3664-3679. http://dx.doi.org/10.1093/hmg/ddz152.
    10.1093/hmg/ddz152
  7. Cardoso, Ana M S; Sousa, Madalena; Morais, Catarina M; Oancea-Castillo, Liliana R; Régnier-Vigouroux, Anne; Rebelo, Olinda; Tão, Hermínio; et al. "MiR-144 overexpression as a promising therapeutic strategy to overcome glioblastoma cell invasiveness and resistance to chemotherapy". Human Molecular Genetics 28 16 (2019): 2738-2751. http://dx.doi.org/10.1093/hmg/ddz099.
    10.1093/hmg/ddz099
  8. Carvalho, Filipa S.; Morais, Catarina M.; Holy, Jon; Krasutsky, Dmytro; Yemets, Sergiy V.; Krasutsky, Pavel A.; Jurado, Amália S.; Oliveira, Paulo J.; Serafim, Teresa L.. "Toxicity of lupane derivatives on anionic membrane models, isolated rat mitochondria and selected human cell lines: Role of terminal alkyl chains". Chemico-Biological Interactions 296 (2018): 198-210. http://dx.doi.org/10.1016/j.cbi.2018.10.002.
    10.1016/j.cbi.2018.10.002
  9. Morais, Catarina M.; Cardoso, Ana M.; Cunha, Pedro P.; Aguiar, Luísa; Vale, Nuno; Lage, Emílio; Pinheiro, Marina; et al. "Acylation of the S413-PV cell-penetrating peptide as a means of enhancing its capacity to mediate nucleic acid delivery: Relevance of peptide/lipid interactions". Biochimica et Biophysica Acta (BBA) - Biomembranes 1860 12 (2018): 2619-2634. http://dx.doi.org/10.1016/j.bbamem.2018.10.002.
    10.1016/j.bbamem.2018.10.002
  10. Araújo, Ana Rita D.; Melo, Tânia; Maciel, Elisabete A.; Pereira, Clara; Morais, Catarina M.; Santinha, Deolinda R.; Tavares, Joana F.; et al. "Errors in protein synthesis increase the level of saturated fatty acids and affect the overall lipid profiles of yeast". PLOS ONE 13 8 (2018): e0202402. http://dx.doi.org/10.1371/journal.pone.0202402.
    10.1371/journal.pone.0202402
  11. Cunha, Pedro P.; Costa, Pedro M.; Morais, Catarina M.; Lopes, Ines R.; Cardoso, Ana M.; Cardoso, Ana L.; Mano, Miguel; Jurado, Amalia S.; Pedroso de Lima, Maria C.. "High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors". Human Molecular Genetics 26 22 (2017): 4375-4387. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000414403900006&KeyUID=WOS:000414403900006.
    10.1093/hmg/ddx323
  12. Cruz, R.Q.; Morais, C.M.; Cardoso, A.M.; Silva, S.G.; Vale, M.L.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S.. "Enhancing glioblastoma cell sensitivity to chemotherapeutics: A strategy involving survivin gene silencing mediated by gemini surfactant-based complexes". European Journal of Pharmaceutics and Biopharmaceutics 104 (2016): 7-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964330230&partnerID=MN8TOARS.
    10.1016/j.ejpb.2016.04.014
  13. Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Silva, S.G.; Do Vale, M.L.; Marques, E.F.; De Lima, M.C.P.; Jurado, A.S.. "New serine-derived gemini surfactants as gene delivery systems". European Journal of Pharmaceutics and Biopharmaceutics 89 (2015): 347-356. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920830778&partnerID=MN8TOARS.
    10.1016/j.ejpb.2014.12.013
  14. Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Cardoso, A.L.; Silva, S.G.; Do Vale, M.L.; Marques, E.F.; Pedroso De Lima, M.C.; Jurado, A.S.. "Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression". Molecular Pharmaceutics 12 3 (2015): 716-730. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924023696&partnerID=MN8TOARS.
    10.1021/mp5005349
  15. Cardoso, A.M.; Morais, C.M.; Silva, S.G.; Marques, E.F.; De Lima, M.C.P.; Jurado, M.A.S.. "Bis-quaternary gemini surfactants as components of nonviral gene delivery systems: A comprehensive study from physicochemical properties to membrane interactions". International Journal of Pharmaceutics 474 1-2 (2014): 57-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906267891&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2014.08.011
  16. Cardoso, A.M.; Calejo, M.T.; Morais, C.M.; Cardoso, A.L.; Cruz, R.; Zhu, K.; Pedroso De Lima, M.C.; Jurado, A.S.; Nyström, B.. "Application of thermoresponsive PNIPAAM-b-PAMPTMA diblock copolymers in siRNA delivery". Molecular Pharmaceutics 11 3 (2014): 819-827. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901742907&partnerID=MN8TOARS.
    10.1021/mp400510a
  17. Monteiro, J.P.; Morais, C.M.; Oliveira, P.J.; Jurado, A.S.. "Mitochondrial membrane lipids in life and death and their molecular modulation by diet: Tuning the furnace". Current Drug Targets 15 8 (2014): 797-810. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904720484&partnerID=MN8TOARS.
    10.2174/1389450115666140623115315
  18. Monteiro, J.P.; Martins, A.F.; Nunes, C.; Morais, C.M.; Lúcio, M.; Reis, S.; Pinheiro, T.J.T.; et al. "A biophysical approach to menadione membrane interactions: Relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects". Biochimica et Biophysica Acta - Biomembranes 1828 8 (2013): 1899-1908. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877072697&partnerID=MN8TOARS.
    10.1016/j.bbamem.2013.04.006
  19. Calejo, M.T.; Cardoso, A.M.S.; Kjøniksen, A.-L.; Zhu, K.; Morais, C.M.; Sande, S.A.; Cardoso, A.L.; et al. "Temperature-responsive cationic block copolymers as nanocarriers for gene delivery". International Journal of Pharmaceutics 448 1 (2013): 105-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875930565&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2013.03.028
  20. Trabulo, S.; Cardoso, A.L.; Cardoso, A.M.S.; Morais, C.M.; Jurado, A.S.; Pedroso de Lima, M.C.. "Cell-penetrating peptides as nucleic acid delivery systems: From biophysics to biological applications". Current Pharmaceutical Design 19 16 (2013): 2895-2923. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878655380&partnerID=MN8TOARS.
    10.2174/1381612811319160006
  21. Cardoso, A.M.S.; Trabulo, S.; Cardoso, A.L.; Lorents, A.; Morais, C.M.; Gomes, P.; Nunes, C.; et al. "S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: Implications for cell internalization". Biochimica et Biophysica Acta - Biomembranes 1818 3 (2012): 877-888. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856059612&partnerID=MN8TOARS.
    10.1016/j.bbamem.2011.12.022
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/11/14 Upgrading S413-PV peptide to mediate gene silencing in cancer cells through peptide lauroylation and histidine-enrichment III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship
(Covilhã, Portugal)
2019/06/26 Long non-protein coding RNA MVIH silencing as a therapeutic approach for glioblastoma 3rd International Symposium on Frontiers in Molecular Science - RNA regulatory networks
(Lisboa, Portugal)
2016/02/12 Interaction of acylated S413-PV analogs with lipid membranes 15th Iberian Peptide Meeting
(Porto, Portugal)
2015/07/09 Membrane interaction of acylated S4(13)PV analogs: understanding their delivery efficiency RICI6-6th Iberian Meeting on Colloids and Interfaces
(Guimarães, Portugal)
2015/05/06 Lipid-based strategies in gene therapy: from design of gene carriers to the modulation of membrane lipids 4th Workshop in Lipidomics
(Aveiro, Portugal)
2014/12/17 Lauroyl derivatives of H5-S4(13)-PV as novel cell-penetrating peptides for siRNA delivery XVIII Congress of the Portuguese Biochemical Society
(Coimbra, Portugal)
2014/10/02 Improving the ability of S4(13)PV cell-penetrating peptide to mediate siRNA delivery through peptide acylation SFNano In vitro/in vivo correlation workshop – Relevant tools and models for the translation of advanced drug delivery systems
(Porto, Portugal)
2014/06/22 Gemini surfactants as gene delivery systems: disclosing the properties leading to transfection activity 20th International Symposium on Surfactants in Solution
(Coimbra, Portugal)
2013/06/26 Gene Transfer Mediated by Bis-Quaternary Gemini Surfactants Depends on Complex Architecture RICI5 – 5th Iberian Meeting on Colloids and Interfaces
(Danostia – San Sebastian, País Basco, Spain)
2011/07/15 Membrane lipid interactions with cell-penetrating peptides: lessons on the role of lipids in membrane functioning RICI4 - 4th Iberian Meeting on Colloids and Interfaces
(Porto, Portugal)
2011/05/30 Transfection efficiency of Gemini surfactant-based gene delivery systems as affected by nature of formulation and method of preparation XXXVI Jornadas Portuguesas de Genética
(Coimbra, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2010/05/11 - 2010/05/14 Colaboração na organização-"Survival or Death as a Matter of Fat" (2010/05/11 - 2010/05/14)
Congress (Other)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/10/01 - 2019/10/06 Comunicação em poster- C.M. Morais, A.M. Cardoso, T. Melo, A.R.D. Araújo, A. Reis, P. Domingues, M.R. Domingues, M.C. Pedroso de Lima and A.S. Jurado, " Silencing of key-enzymes of lipid metabolism combined with multitargeted receptor tyrosine kinase inhibitors as a new therapeutic strategy for glioblastoma”
Congress
 2nd FEBS Advanced Lecture Course on Oncometabolism-From Conceptual Knowledge to Clinical Applications
2019/09/23 - 2019/09/25 Training course (6th edition)- From the basics to LC-MS data acquisition and interpretation
Workshop
Universidade de Aveiro Centro de Espectrometria de Massa, Portugal
2018/01/14 - 2018/01/16 Comunicação em poster- C.M. Morais, S.C. Lopes, M.C. Pedroso de Lima and A.S. Jurado, "S413-PV-derived peptides as promising nucleic acid delivery systems in hard-to-transfect cell cultures"
Conference
 XII Spanish-Portuguese Conference on Controlled Drug Delivery
Universidade de Coimbra, Portugal
2018/01/14 - 2018/01/16 Comunicação em poster- P.P. Cunha, C.M. Morais, I.R. Lopes, B. Mestre, A.S. Jurado, and M.C. Pedroso de Lima, "Differentiation therapy toward glioblastoma stem-like cells"
Conference
 XII Spanish-Portuguese Conference on Controlled Drug Delivery
Universidade de Coimbra, Portugal
2018/01/14 - 2018/01/16 Comunicação em poster- C.M. Morais, S.C. Lopes, M.C. Pedroso de Lima and A.S. Jurado, "Exploring SCD1 silencing in GBM"
Conference
 XII Spanish-Portuguese Conference on Controlled Drug Delivery
Universidade de Coimbra, Portugal
2017/09/04 - 2017/09/15 Summer School in Computational Biology
Workshop
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017 - 2017 Comunicação em poster- Beatriz Mestre, Catarina M. Morais, Pedro Cunha, Ana Reis, Rita Araújo, Ana M. Cardoso, Maria R. Domingues, Maria C. Pedroso de Lima, Amália S. Jurado, “Lipid composition of human glioblastoma cells: alterations induced by a new generation chemotherapeutic agent”
Meeting
 9th Biochemistry Day
Universidade de Aveiro, Portugal
2016/09/04 - 2016/09/09 Comunicação em poster- Catarina M. Morais, Pedro Cunha, Ana M. Cardoso, Luísa Aguiar, Nuno Vale, Emílio V. Lage, Marina Pinheiro, Cláudia Nunes, Salette Reis, Paula Gomes, Maria C. P. de Lima and Amália S. Jurado, “Membrane perturbations induced by acylated S4(13)-PV analogs: relevance to nucleic acid delivery”
Symposium
 34th European Peptide Symposium, Leipzig, Germany
2016 - 2016 Comunicação em poster- Ana Rita Araújo, M. Rosário Domingues, Elisabete Maciel, Tânia Melo, Deolinda Santinha, Diana Antunes, Doron Rapaport, Catarina Morais, Amália Jurado, Vìtor Costa, Clara Pereira, Manuel Santos, Pedro Domingues, “Effects of mistranslation in Saccharomyces cerevisiae: a lipidomics study”
Conference
 IX National Conference on Biochemistry, Guimarães, Portugal
2015 - 2015 Comunicação em poster- Pedro P. Cunha, Pedro Costa, Raquel Costa, Carlos Custódia, Ruben Branco, Catarina M. Morais, Ana M. Cardoso, Ana L. Cardoso, Amália S. Jurado and Maria C.P. Lima, “MicroRNA modulation renders glioblastoma cells sensitive to chemotherapy”
Congress
 49th Annual Scientific Meeting of the European Society for Clinical Investigation, Cluj-Napoca, Romania
2014/12 - 2014/12 Comunicação em poster- Rita Q. Cruz, Catarina M. Morais, Ana M. Cardoso, Sandra G. Silva, Maria L. Vale, Eduardo F. Marques, Maria C.P. de Lima, Amália S. Jurado, “Gene silencing mediated by gemini-based formulations”
Congress
 XVIII Congress of the Portuguese Biochemical Society, Coimbra, Portugal
2014/12 - 2014/12 Comunicação em poster- Pedro Cunha, Pedro Costa, Raquel Costa, Rúben Branco, Catarina Morais, Ana M. Cardoso, Ana L. Cardoso, Amália Jurado and Maria da Conceição Pedroso de Lima, “MicroRNA-21 and micro RNA-128 modulation sensitizes glioblastoma cells to sunitinib treatement”
Congress
 XVIII Congress of the Portuguese Biochemical Society, Coimbra, Portugal
2013/04/10 - 2013/04/10 Workshop: 2nd workshop in Lipidomics
Workshop
Universidade de Aveiro Centro de Espectrometria de Massa, Portugal
2013 - 2013 Comunicação em poster- Catarina Morais, Ana Cardoso, Rita Cruz, Dmytro Krasutsky, Oksana Kolomitsyn, Pavel Krasutsky, Paulo Oliveira, Conceição Lima, Amália Jurado, “Nuclear and mitochondrial gene transfection mediated by cationic pentacyclic triterpenoid derivatives”
Congress
 GEM/GERLI Lipidomics Meeting: From Membranes to Pathologies, Saint Jean Cap Ferrat, França
2013 - 2013 Comunicação em poster- Ana M. Cardoso, Catarina M. Morais, Sandra G. Silva, M. Luísa do Vale, Eduardo Marques, Maria C. Pedroso Lima and Amália S. Jurado, “The structural architecture of Bis-quat gemini surfactants is crucial for their DNA delivery ability”
Congress
 9th EBSA – European Biophysics Congress, Lisboa, Portugal
2012/06/11 - 2012/06/15 Workshop: NMR Basics: Theory, processing and Applications
Workshop
2011 - 2011 Comunicação em poster- A. M. S. Cardoso, C. M. Morais, S. G. Silva, M. L. do Vale, A. A. C. C. Pais, E. F. Marques, M. C. Pedroso de Lima and A. S. Jurado, “Gemini Surfactant-Based Gene Delivery Systems: Transfection Efficiency And Cytotoxicity Depend On Hydrocarbon Chain Length And Helper Lipids”
Conference
 III Congress of the Portuguese Society of Pharmaceutical Sciences/IX Spanish-Portuguese Conference on Controlled Drug Delivery - New Trends in Pharmacological Sciences, Porto, Portugal
2011 - 2011 Comunicação em poster- A. M. S. Cardoso, C. M. Morais, S. G. Silva, M. L. do Vale, A. A. C. C. Pais, E. F. Marques, M. C. Pedroso de Lima, A. S. Jurado, “Transfection efficiency of Gemini surfactant-based gene delivery systems as affected by helper lipids”
Congress
 RICI4 - 4th Iberian Meeting on Colloids and Interfaces, Porto, Portugal
2010 - 2010 Comunicação em poster- Catarina M. Morais, Oksana Kolomitsyn, Pavel Krasutsky, Paulo J. Oliveira, Amália Jurado, "The pentacyclic triterpenoids ok210 and ok204 as membrane modulators: impact on mitochondrial and bacterial respiratory activity”
Congress
 International Courses on Toxicology held at the Center for Neurosciences and Cell Biology, Coimbra, Portugal