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Américo J. S. Alves received his BSc in Chemistry from the University of Coimbra in 2015 and his MSc in Chemistry (specialization in Advanced and Industrial Chemistry) in 2016. He completed his Ph.D. in Organic Chemistry (2023) at University of Coimbra, with a thesis entitled ¿Novel Spiro-Lactams as New Antimicrobial Agents¿. Currently, he holds a position as a PhD researcher and is conducting research activity at the Coimbra Chemistry Center (CQC) ¿ Institute of Molecular Sciences (IMS). Américo Alves is the author/co-author of 11 research papers published in international journals, and has presented 17 oral/poster communications at national and international scientific meetings. He was co-supervisor of 9 academic degree dissertations (BSc and MSc) and co-supervisor of 4 master students¿ rotation internships. Américo Alves received an honourable mention for the best PhD thesis in Organic Chemistry (2023), and was a team member of the projects that won BfK Ideas 2020, R2 Value¿s 2022, and Gilead Génese 2023. He is also co-founder of BSL Pharmaceutics and Molecular JE. His research interests are in the field of heterocyclic chemistry, flow chemistry and medicinal chemistry.
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Identification

Personal identification

Full name
Américo José dos Santos Alves

Citation names

  • Alves, Américo
  • Américo J. S. Alves

Author identifiers

Ciência ID
A018-F2DF-D0C4
ORCID iD
0000-0003-2175-8796

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
German Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2017/11 - 2023/01/09
Concluded
 Chemistry (Doutoramento)
Major in Organic Synthesis
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
"Novel spiro-lactams as new antimicrobial agents" (THESIS/DISSERTATION)
 Aprovado com Distinção e Louvor por Unanimidade
2016
Concluded
 Master's Degree in Chemistry (Mestrado)
Major in Advanced and Industrial Chemistry
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Furanos na Síntese de Novos Compostos Heterocíclicos" (THESIS/DISSERTATION)
 17
2015
Concluded
 Bachelor's Degree in Chemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2022/10 - Current Researcher (Research) Universidade de Coimbra Centro de Química de Coimbra, Portugal
2017/04 - 2017/10 Researcher (Research) Universidade de Coimbra Centro de Química de Coimbra, Portugal
Projects

Grant

Designation Funders
2023/07 - Current ResFinas - Modificação de resinas de colofónia para promover a compatibilidade dos seus derivados com poliolefinas produzidas por catálise com metalocenos
ResFinas
Post-doc Fellow
2022/10 - 2023/06 TheraBullet - Complexos de Pt(II) derivados duma nova classe de clorinas: Validação de agentes de teranóstico do cancro
TheraBullet
Master Student Fellow
2017/11 - 2021/10 Novel spiro-lactams as new antimicrobial agents
SFRH/BD/128910/2017
 Fundação para a Ciência e a Tecnologia
2017/04 - 2017/10 NEUROTERA - "Para a introdução no mercado de novos agentes terapêuticos contra co-morbilidades oculares e cerebrais associdas à Paramiloidose"
POCI-01-0247-FEDER-003431
Master Student Fellow
Concluded
Outputs

Publications

Conference poster
  1. Alfredo Bartolomeu; Américo J. S. Alves; Correia-Barros, Gabriela; Susana M. M. Lopes; Laranjo, Mafalda; Pineiro, Marta; Botelho, Maria Filomena; Teresa M. V. D. Pinho e Melo. "Advances in Platinum(II)-based Chlorins: Scale-up, Chemical Modulation and Photodynamic Activity". Paper presented in XXVIII Encontro Nacional da SPQ, 2024.
  2. Américo J. S. Alves; João A. D. Silvestre; Teresa M. V. D. Pinho e Melo. "Continuous Flow Phosphine-Catalyzed [3+2] Annulation of Allenoates: Towards Efficient Synthesis of Chiral Spirocyclopentene-Penicillanates". Paper presented in 15th National Organic Chemistry Meeting (15ENQO), and the 8th National Medicinal Chemistry Meeting (8ENQT), 2024.
  3. João V. R. Gonçalves; Américo J. S. Alves; Bártolo, Inês; Nuno Eduardo Moura dos Santos da Costa Taveira; Teresa M. V. D. Pinho e Melo. "Novel Spiro-Penicillanates From 6-Alkylidenepenicillanates Via Formal Cycloadditions of Allenoates And Dimethylsulfonium Ylides". Paper presented in 8° Encontro Português de Jovens Químicos (PYCheM), 2023.
  4. Inês Bártolo; Inês Moranguinho; Paloma Gonçalves; Pedro Borrego; Perpétua Gomes; Fátima Gonçalves; Américo J. S. Alves; et al. "Spiro-ß-lactam BSS-730A presents potent activity against RNA respiratory viruses and HIV". Paper presented in ASM Microbe 2022, 2022.
  5. Alves, Américo J. S. (A018-F2DF-D0C4); Nuno G. Alves; Laranjo, Mafalda; Ana Cristina Gonçalves; Ana Bela Sarmento-Ribeiro; Botelho, Maria Filomena; Teresa M. V. D. Pinho e Melo. Corresponding author: Alves, Américo J. S. (A018-F2DF-D0C4). "Chiral a-Alkylidene-Substituted ß-Lactams and ¿-Lactams: Synthesis and Anticancer Activity". Paper presented in XXI SPB National Congress of Biochemistry 2020, 2021.
  6. Américo J. S. Alves; Inês Bártolo; Nuno Taveira; Teresa M. V. D. Pinho e Melo. "Synthesis and Anti-Hiv Evaluation of New Chiral Spiro-ß-Lactams". Paper presented in Coimbra Chemistry Center Day, 2021.
  7. Nuno Guerreiro Alves; Américo J. S. Alves; Inês Bártolo; Miguel Prudêncio; Nuno Taveira; Teresa M. V. D. Pinho e Melo. "A novel spiro-ß-lactam with potent anti-HIV and anti-plasmodial activity". Paper presented in 13.º Encontro Nacional de Química Orgânica (13ENQO) / 6.º Encontro Nacional de Química Terapêutica (6ENQT), 2020.
  8. Américo J. S. Alves; Nuno Guerreiro Alves; Diana Fontinha; Inês Bártolo; Maria Isabel Lopes Soares; Susana Margarida Martins Lopes; Miguel Prudêncio; Nuno Taveira; Teresa M. V. D. Pinho e Melo. "Structural Insights into the Distinct Antimicrobial Profile of Spiro-beta- and Spiro-gama-Lactam". Paper presented in 13.º Encontro Nacional de Química Orgânica (13ENQO) / 6.º Encontro Nacional de Química Terapêutica (6ENQT), 2020.
  9. Américo J. S. Alves; Maria Isabel Lopes Soares; Susana Margarida Martins Lopes; Miguel Prudêncio; Nuno Taveira; Teresa M. V. D. Pinho e Melo. "Synthesis of Novel Chiral Spiro-Lactams from Alkylidene-Lactams". Paper presented in International Symposium on Synthesis and Catalysis (ISySyCat), 2019.
  10. Américo J. S. Alves; Susana Margarida Martins Lopes; Teresa M. V. D. Pinho e Melo. "Synthesis of Nitrogen-Containing Heterocycles from Furans". Paper presented in 5th Portuguese Young Chemists Meeting (5th PYCheM) and 1st European Young Chemists Meeting (1st EYCheM) - Guimarães, 2016.
  11. Américo J. S. Alves; Susana Margarida Martins Lopes; Teresa M. V. D. Pinho e Melo. "Furans as Scaffolds for the Synthesis of Novel Heterocyclic Compounds". Paper presented in III Simpósio Iberoamericano de Química Orgânica (SIBEAQO III) - Porto, 2016.
  12. Alves, Américo J. S.; Lopes, Susana M. M.; Teresa M. V. D. Pinho e Melo. "Exploring the Chemistry of Furans: Synthesis of Functionalized Bis(furan-2-yl)methanes and 1,6-Dihydropyridazines". Paper presented in 11º Encontro Nacional de Química Orgânica / 4º Encontro Nacional de Química Terapêutica, 2015.
  13. Lopes, Susana M. M.; Alves, Américo J. S. (A018-F2DF-D0C4); Pinho e Melo, Teresa M. V. D.. "Funcionalization of Bis(furan-2-yl)methanes via hetero-Diels-Alder reactions of nitrosoalkenes and azoalkenes". Paper presented in 19th European Symposium of Organic Chemistry (ESOC2015), 2015.
Journal article
  1. Inês Bártolo; Inês Moranguinho; Paloma Gonçalves; Ana Rita Diniz; Pedro Borrego; Francisco Martin; Inês Figueiredo; et al. "High Instantaneous Inhibitory Potential of Bictegravir and the New Spiro-ß-Lactam BSS-730A for HIV-2 Isolates from RAL-Naïve and RAL-Failing Patients". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232214300.
    10.3390/ijms232214300
  2. Alves, Américo J. S.; Alves, Nuno G.; Bártolo, Inês; Fontinha, Diana; Caetano, Soraia; Prudêncio, Miguel; Taveira, Nuno; Pinho e Melo, Teresa M. V. D.. "Unveiling a family of spiro-ß-lactams with anti-HIV and antiplasmodial activity via phosphine-catalyzed [3+2] annulation of 6-alkylidene-penicillanates and allenoates". Frontiers in Chemistry 10 (2022): http://dx.doi.org/10.3389/fchem.2022.1017250.
    10.3389/fchem.2022.1017250
  3. Alves, Américo J.S.; Alves, Nuno G.; Laranjo, Mafalda; Gomes, Clara S.B.; Cristina Gonçalves, Ana; Bela Sarmento-Ribeiro, Ana; Filomena Botelho, M.; Pinho e Melo, Teresa M.V.D.. "Insights into the anticancer activity of chiral alkylidene-ß-lactams and alkylidene-¿-lactams: Synthesis and biological investigation". Bioorganic & Medicinal Chemistry 63 (2022): 116738. http://dx.doi.org/10.1016/j.bmc.2022.116738.
    10.1016/j.bmc.2022.116738
  4. Américo J. S. Alves; João A. D. Silvestre; Teresa M. V. D. Pinho e Melo. "Synthesis of novel chiral spiro-ß-lactams from nitrile oxides and 6-(Z)-(benzoylmethylene)penicillanate: batch, microwave-induced and continuous flow methodologies". RSC Advances (2022): https://doi.org/10.1039/D2RA04848E.
    10.1039/D2RA04848E
  5. Nuno Guerreiro Alves; Inês Bártolo; Américo J.S. Alves; Diana Fontinha; Denise Francisco; Susana M.M. Lopes; Maria I.L. Soares; et al. "Synthesis and structure-activity relationships of new chiral spiro-ß-lactams highly active against HIV-1 and Plasmodium". European Journal of Medicinal Chemistry 219 (2021): 113439-113439. https://doi.org/10.1016%2Fj.ejmech.2021.113439.
    10.1016/j.ejmech.2021.113439
  6. Américo J. S. Alves. "Spiro-ß-lactam BSS-730A Displays Potent Activity against HIV and Plasmodium". ACS Infectious Diseases (2021): http://dx.doi.org/10.1021/acsinfecdis.0c00768.
    10.1021/acsinfecdis.0c00768
  7. Américo J. S. Alves; Nuno G. Alves; Maria I. L. Soares; Teresa M. V. D. Pinho e Melo. "Strategies and methodologies for the construction of spiro-¿-lactams: an update". Organic Chemistry Frontiers (2021): https://doi.org/10.1039/D0QO01564D.
    10.1039/D0QO01564D
  8. Alves, N.G.; Alves, A.J.S.; Soares, M.I.L.; Pinho e Melo, T.M.V.D.. "Recent Advances in the Synthesis of Spiro-ß-Lactams and Spiro-d-Lactams". Advanced Synthesis and Catalysis (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85103647243&partnerID=MN8TOARS.
    10.1002/adsc.202100013
  9. Américo J. S. Alves; Teresa M. V. D. Pinho e Melo. "Synthesis of Novel Chiral Spiroisoxazolidine-ß-Lactams from 6-Alkylidenepenicillanates: A 1,3-Dipolar Cycloaddition Approach". European Journal of Organic Chemistry 2020 39 (2020): 6259-6269. https://doi.org/10.1002/ejoc.202001085.
    10.1002/ejoc.202001085
  10. Américo J. S. Alves; Nuno Guerreiro Alves; Cátia C. Caratão; Margarida I. M. Esteves; Diana Fontinha; Inês Bártolo; Maria Isabel Lopes Soares; et al. "Spiro-Lactams as Novel Antimicrobial Agents". Current Topics in Medicinal Chemistry (2019): http://dx.doi.org/10.2174/1568026619666191105110049.
    10.2174/1568026619666191105110049
  11. Alves, Américo J. S.; Lopes, Susana M. M.; Henriques, Marta S. C.; Paixão, José A.; Pinho e Melo, Teresa M. V. D.. "Hetero-Diels-Alder and Ring-Opening Reactions of Furans Applied to the Synthesis of Functionalized Heterocycles". European Journal of Organic Chemistry 2017 27 (2017): 4011-4025. http://dx.doi.org/10.1002/ejoc.201700453.
    10.1002/ejoc.201700453

Other

Other output
  1. Novel Chiral Spiro-ß-Lactams from Alkylidenepenicillanates via Cycloaddition Reactions: Synthesis and Anti-HIV Activity. Oral communication at International Symposium on Synthesis and Catalysis (ISySyCat2021) – Évora. 2021. Alves, Américo; Bártolo, Inês; Nuno G. Alves; Taveira, Nuno; Teresa M. V. D. Pinho e Melo.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/09 Batch and Continuous Flow Synthesis of Novel Spiro-ß-Lactams with Antiviral Activity International Symposium on Synthesis and Catalysis (ISySyCat2023)
2022 New Chiral Spiro-ß-Lactams via [3+2] annulation of allenoates with 6-alkylidenepenicillanates: Synthesis and Anti-HIV Activity 14º Encontro Nacional de Química Orgânica / 7º Encontro Nacional de Química Terapêutica
2022 Pitch at “Startup Capital Summit” (SPIRO4MALAIDS) Startup Capital Summit
2021 Novel Chiral Spiro-ß-Lactams from Alkylidenepenicillanates via Cycloaddition Reactions: Synthesis and Anti-HIV Activity International Symposium on Synthesis and Catalysis (ISySyCat2021)
2021 Pitch at “INOVAÇÃO@UC” (BSL Pharmaceutics) INOVAÇÃO@UC
2019 Spiro-Lactams as Novel Antimicrobial Agents Workshop “Estratégias de Descoberta de Fármacos”
2019 Novel spiro-lactams as new antimicrobial agents Organic Synthesis & Catalysis Workshop (LAQV - Paul Knochel Seminar)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09 - Current Síntese de novos derivados de colofónia compatíveis com poliolefinas
Co-supervisor of Pedro Miranda
 Química (Master)
Universidade de Coimbra Departamento de Química, Portugal
2022/09 - 2023/09 NOVAS ESTRATÉGIAS PARA A SÍNTESE DE ESPIRO-ß-LACTAMAS QUIRAIS
Co-supervisor of João Vítor
 Química (Master)
Universidade de Coimbra Departamento de Química, Portugal
2021/09 - 2023/09 Synthesis of Novel Spiro-ß-lactams with Potent Antimicrobial Activity: Studying Continuous Flow Reaction Conditions
Co-supervisor of João A. D. Silvestre
 Química (Master)
Universidade de Coimbra Departamento de Química, Portugal

Committee member

Activity description
Role 		Institution / Organization
2021 - Current Co-founder of BSL Pharmaceutics
2017 - Current Co-founder of Molecular JE

Mentoring / Tutoring

Topic Student name
2024/02 - 2024/07 Continuous Flow Synthesis of Spiro-ß-Lactams with Antiviral Activity Andresa Dias
2024/01 - 2024/07 NOVEL SPIRO-ß-LACTAMS AS BROAD-SPECTRUM ANTIVIRALS FOR RNA VIRUSES Ricardo Carvalho
2023/02 - 2023/07 Novel Spiro-ß-Lactams as Broad-Spectrum Antivirals Livia Stenico
2023/02 - 2023/07 Novel Spiro-ß-lactams as Broad-Spectrum Antivirals Bruno Castro
2022/01 - 2022/07 Síntese de novas espiro-ß-lactamas quirais a partir de diazopenicilanatos via reações de ciclo-adição em fluxo continuo Pedro Sá
2022/01 - 2022/07 Flow Synthesis of Novel Spiro-ß-lactams with Potent Antimicrobial Activity: Studying Continuous Flow Reaction Conditions Luísa Sousa
2022/01 - 2022/07 Synthesis of Novel Spiro-ß-penicillanates João Vitor
2021/01 - 2021/07 Ciclo-adição 1,3-Dipolar Para A Síntese De Espiroisoxazolino-ß-Penicilanatos Quirais: Abordagem Convencional E Em Fluxo Contínuo João Vítor
2021/01 - 2021/07 1,3-Dipolar Cycloaddition in the Synthesis of Novel Spiro-ß-Lactams with Antimicrobial Activity Catarina Guardado
2021/01 - 2021/07 Novas Espiro-ß-lactamas com Potencial Atividade Antimicrobiana Carina Pedrosa
Distinctions

Award

2024 Honourable mention of the "Portuguese Award for Best PhD Thesis in Organic Chemistry 2023"
2022 Winner of "Gilead Génese 2023", in the area of Virology with the project “Spiro-ß-lactams as broad-spectrum host-directed drugs for RNA respiratory viruses”.
2022 R2 Value's 2022 Edition, sponsored by NOVA.id.FCT
2021 Winner of "Born from Knowledge Ideas" (BfK Ideas), in the area of “Soluções Tecnológicas para a Prevenção, Deteção e Tratamento do COVID-19” with the project SPIRO4MALAIDS – Agência Nacional da Inovação.
2020 Winner of Best Poster Communication in Medicinal Chemitry - 13th National Organic Chemistry Meeting - 6th National Medicinal Chemistry Meeting (Universidade de Aveiro, Aveiro, 15-17 janeiro 2020) - co-author