???global.info.a_carregar???
Identification

Personal identification

Full name
Gustavo Mostoslavsky

Citation names

  • Mostoslavsky, Gustavo

Author identifiers

Ciência ID
A01E-3641-EA04
ORCID iD
0000-0002-0784-2169
Education
Degree Classification
2001
Concluded
 Immunology Mol. Biology (Doctor of Philosophy)
The Hebrew University of Jerusalem, Israel
1994
Concluded
 Medicine (Master)
Universidad Nacional de Tucumán, Argentina
Affiliation

Science

Category
Host institution 		Employer
2001 - 2007 Researcher (Research) Boston Children's Hospital, United States
2001 - 2007 Researcher (Research) Harvard Medical School, United States

Teaching in Higher Education

Category
Host institution 		Employer
2015 - Current Associate Professor (University Teacher) Boston University, United States
2008 - 2015 Assistant Professor (University Teacher) Boston University, United States
2007 - 2007 Lecturer (University Teacher) Harvard Medical School, United States
1996 - 2000 Assistant Professor (University Teacher) The Hebrew University of Jerusalem Department of Plant Pathology and Microbiology, Israel
1990 - 1992 Assistant Professor (University Teacher) Universidad Nacional de Tucumán, Argentina

Others

Category
Host institution 		Employer
2009 - Current Founder and Co-Director Center for Regenerative Medicine (CReM) Boston University School of Medicine, United States
Projects

Grant

Designation Funders
2016/09/21 - 2023/05 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage
U01HL134766
 National Institutes of Health
Ongoing
2017/01/10 - 2022/09/30 THE ROLE OF INTERFERON REGULATORY FACTOR 5 IN THE PATHOGENESIS OF SLE
R01AI130199
 National Institutes of Health
Ongoing
2019/03/15 - 2021/02/28 Modeling prion diseases using human iPSC-derived neurons
1R21NS111499-01
Integration into Research Grant Fellow
Ongoing
2019/03 - 2021/02 Modeling prion diseases using human iPSC-derived neurons
1R21NS111499-01
 N/A
2017/09/30 - 2019/08 Engineering a 3D human neurovascular unit for investigating and countering neuroinflammatory mechanisms of HIV
R21NS105837-01
National Institutes of Health
Concluded
2017/09 - 2019/08 Engineering a 3D human neurovascular unit for investigating and countering neuroinflammatory mechanisms of HIV
R21NS105837-01
 National Institutes of Health
2016/06/30 - 2019/06/29 Antiviral responses in iPSC-derived human primary cells to Ebola virus infection
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES/5R21AI126457-02/US
Post-doc
National Institute of Allergy and Infectious Diseases, United States
 National Institute of Allergy and Infectious Diseases
Concluded
2016/06/30 - 2019/06/29 Antiviral responses in iPSC-derived human primary cells to Ebola virus infection
5R21AI126457-02
National Institutes of Health
Concluded
2016/06 - 2019/06 Antiviral responses in iPSC-derived human primary cells to Ebola virus infection
5R21AI126457-02
 National Institutes of Health
2014/08/15 - 2019/04/30 A National Resource for Lung disease-specific iPS cells
1R24HL123828-01
National Institutes of Health
Concluded
2014/08 - 2019/04 A National Resource for Lung disease-specific iPS cells
1R24HL123828-01
 National Institutes of Health
2013/06/01 - 2018/05 The Role of SIRT6 and Metabolism in APC Mediated Tumorigenesis
1R01CA175727-01
 National Institutes of Health
Ongoing
2011/07/05 - 2016/05/30 Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
1U01HL107443-01
 National Institutes of Health
Concluded
Outputs

Publications

Journal article
  1. Mithal, Aditya; Capilla, Amalia; Heinze, Dar; Berical, Andrew; Villacorta-Martin, Carlos; Vedaie, Marall; Jacob, Anjali; et al. "Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-019-13916-6.
    10.1038/s41467-019-13916-6
  2. Cesar A. Sommer; Jozef Dulak; Amalia Capilla; Francisco J. Molina-Estevez; Andreia Gianotti-Sommer; Nicholas Skvir; Ignacio Caballero; Sanjib Chowdhury; Gustavo Mostoslavsky. "Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells". PLOS ONE 13 7 (2018): e0200657-e0200657. https://doi.org/10.1371/journal.pone.0200657.
    10.1371/journal.pone.0200657
  3. Park, Seonmi; Gianotti-Sommer, Andreia; Molina-Estevez, Francisco Javier; Vanuytsel, Kim; Skvir, Nick; Leung, Amy; Rozelle, Sarah S.; et al. "A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells". Stem Cell Reports 8 4 (2017): 1076-1085. http://dx.doi.org/10.1016/j.stemcr.2016.12.017.
    10.1016/j.stemcr.2016.12.017
  4. Schlimgen, Ryan; Howard, John; Wooley, Dawn; Thompson, Maureen; Baden, Lindsey R.; Yang, Otto O.; Christiani, David C.; et al. "Risks Associated With Lentiviral Vector Exposures and Prevention Strategies". Journal of Occupational and Environmental Medicine 58 12 (2016): 1159-1166. http://dx.doi.org/10.1097/jom.0000000000000879.
    10.1097/jom.0000000000000879
  5. Sommer, Cesar A.; Stadtfeld, Matthias; Murphy, George J.; Hochedlinger, Konrad; Kotton, Darrell N.; Mostoslavsky, Gustavo. "Induced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette". Stem Cells 27 3 (2009): 543-549. http://dx.doi.org/10.1634/stemcells.2008-1075.
    10.1634/stemcells.2008-1075
  6. Mammoto, Akiko; Connor, Kip M.; Mammoto, Tadanori; Yung, Chong Wing; Huh, Dongeun; Aderman, Christopher M.; Mostoslavsky, Gustavo; Smith, Lois E. H.; Ingber, Donald E.. "A mechanosensitive transcriptional mechanism that controls angiogenesis". Nature 457 7233 (2009): 1103-1108. http://dx.doi.org/10.1038/nature07765.
    10.1038/nature07765
  7. Mammoto, Akiko; Connor, Kip M.; Mammoto, Tadanori; Yung, Chong Wing; Huh, Dongeun; Aderman, Christopher M.; Mostoslavsky, Gustavo; Smith, Lois E. H.; Ingber, Donald E.. "A mechanosensitive transcriptional mechanism that controls angiogenesis". Nature 457 7233 (2009): 1103-1108. http://dx.doi.org/10.1038/nature07765.
    10.1038/nature07765
  8. Mostoslavsky, G.; Fabian, A. J.; Rooney, S.; Alt, F. W.; Mulligan, R. C.. "Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer". Proceedings of the National Academy of Sciences 103 44 (2006): 16406-16411. http://dx.doi.org/10.1073/pnas.0608130103.
    10.1073/pnas.0608130103

Intellectual property

Patent
  1. Mostoslavsky, Gustavo; Sommer CA. 2008. "A single Lentiviral Vector System for Induced Pluripotent (IPS) Stem Cells Derivation.".
    Allowed

Other

Standard or policy
  1. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation.. 2013. Mostoslavsky, Gustavo.
    10.1182/blood-2012-11-466722
  2. Cell reprogramming requires silencing of a core subset of polycomb targets.. 2013. Mostoslavsky, Gustavo.
    10.1371/journal.pgen.1003292
  3. FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes.. 2013. Mostoslavsky, Gustavo.
    10.1016/j.bbrc.2013.01.113
  4. The evolving field of induced pluripotency: Recent progress and future challenges.. 2013. Mostoslavsky, Gustavo.
    10.1002/jcp.24155
  5. Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells.. 2013. Mostoslavsky, Gustavo.
    10.1016/j.stem.2013.01.006
  6. Residual expression of reprogramming factors affects the transcriptional program and epigenetic signatures of induced pluripotent stem cells.. 2012. Mostoslavsky, Gustavo.
    10.1371/journal.pone.0051711
  7. Clonal allelic predetermination of immunoglobulin-? rearrangement.. 2012. Mostoslavsky, Gustavo.
    10.1038/nature11496
  8. New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer.. 2012. Mostoslavsky, Gustavo.
    10.1186/1479-5876-10-48
  9. Concise review: the magic act of generating induced pluripotent stem cells: many rabbits in the hat.. 2012. Mostoslavsky, Gustavo.
    10.1002/stem.742
  10. Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes.. 2011. Mostoslavsky, Gustavo.
    10.1172/JCI43853
  11. Critical-size calvarial bone defects healing in a mouse model with silk scaffolds and SATB2-modified iPSCs.. 2011. Mostoslavsky, Gustavo.
    10.1016/j.biomaterials.2011.03.053
  12. Tet1 and tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.. 2011. Mostoslavsky, Gustavo.
    10.1016/j.stem.2011.01.008
  13. BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas.. 2011. Mostoslavsky, Gustavo.
    10.1016/j.cellsig.2011.01.018
  14. Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.. 2011. Mostoslavsky, Gustavo.
    10.1186/1471-2172-12-3
  15. Application of induced pluripotent stem (iPS) cells in periodontal tissue regeneration.. 2011. Mostoslavsky, Gustavo.
    10.1002/jcp.22316
  16. An ES-Like Pluripotent State in FGF-Dependent Murine iPS cells.. 2010. Mostoslavsky, Gustavo.
    10.1371/journal.pone.0016092
  17. Induced pluripotent stem cells: A novel frontier in the study of human primary immunodeficiencies.. 2010. Mostoslavsky, Gustavo.
    10.1016/j.jaci.2010.11.008
  18. Enhanced reprogramming and cardiac differentiation of human keratinocytes derived from plucked hair follicles, using a single excisable lentivirus.. 2010. Mostoslavsky, Gustavo.
    10.1089/cell.2010.0027
  19. Benefits of utilizing gene-modified iPSCs for clinical applications.. 2010. Mostoslavsky, Gustavo.
    10.1016/j.stem.2010.09.010
  20. Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.. 2010. Mostoslavsky, Gustavo.
    10.1002/stem.495
  21. Experimental approaches for the generation of induced pluripotent stem cells.. 2010. Mostoslavsky, Gustavo.
    10.1186/scrt26
  22. Reprogramming of human peripheral blood cells to induced pluripotent stem cells.. 2010. Mostoslavsky, Gustavo.
    10.1016/j.stem.2010.06.002
  23. Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells.. 2009. Mostoslavsky, Gustavo.
    10.1038/ng.428
  24. Induced pluripotent stem cell generation using a single lentiviral stem cell cassette.. 2009. Mostoslavsky, Gustavo.
    10.1634/stemcells.2008-1075
  25. A mechanosensitive transcriptional mechanism that controls angiogenesis.. 2009. Mostoslavsky, Gustavo.
    10.1038/nature07765
  26. Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome.. 2008. Mostoslavsky, Gustavo.
    10.1172/JCI33764
  27. Dual-promoter lentiviral system allows inducible expression of noxious proteins in macrophages.. 2007. Mostoslavsky, Gustavo.
    10.1016/j.jim.2007.09.009
  28. Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells.. 2007. Mostoslavsky, Gustavo.
    10.1038/sj.leu.2404769
  29. Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo.. 2007. Mostoslavsky, Gustavo.
    10.1074/jbc.M702169200
  30. PPARalpha deficiency in inflammatory cells suppresses tumor growth.. 2007. Mostoslavsky, Gustavo.
    10.1371/journal.pone.0000260
  31. Isolation of amniotic stem cell lines with potential for therapy.. 2007. Mostoslavsky, Gustavo.
    10.1038/nbt1274
  32. Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer.. 2006. Mostoslavsky, Gustavo.
    10.1073/pnas.0608130103
  33. Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli.. 2006. Mostoslavsky, Gustavo.
    10.1016/j.yexcr.2006.10.011
  34. Exogenous control of mammalian gene expression via modulation of translational termination.. 2006. Mostoslavsky, Gustavo.
    10.1038/nm1376
  35. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice.. 2006. Mostoslavsky, Gustavo.
    10.1073/pnas.0601938103
  36. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.. 2006. Mostoslavsky, Gustavo.
    10.1016/j.cell.2005.11.044
  37. Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation.. 2005. Mostoslavsky, Gustavo.
    10.1016/j.ymthe.2005.01.005
  38. Cytokine-induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteries.. 2004. Mostoslavsky, Gustavo.
    10.1161/01.CIR.0000143161.01901.BD
  39. Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.. 2004. Mostoslavsky, Gustavo.
    10.1074/jbc.M305783200
  40. The efficiency of B cell receptor (BCR) editing is dependent on BCR light chain rearrangement status.. 2002. Mostoslavsky, Gustavo.
    10.1002/1521-4141(200204)32:4<1164::AID-IMMU1164>3.0.CO;2-1
  41. Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: a case for tissue injury by molecular mimicry.. 2001. Mostoslavsky, Gustavo.
    10.1002/1521-4141(200104)31:4<1221::AID-IMMU1221>3.0.CO;2-P
  42. Production of high affinity autoantibodies in autoimmune New Zealand Black/New Zealand white F1 mice targeted with an anti-DNA heavy chain.. 1999. Mostoslavsky, Gustavo.
    Not found
  43. Early anti-nucleosome autoantibodies from a single MRL+/+ mouse: fine specificity, V gene structure and pathogenicity.. 1998. Mostoslavsky, Gustavo.
    10.1002/(SICI)1521-4141(199811)28:11<3411::AID-IMMU3411>3.0.CO;2-G
Activities

Association member

Society Organization name Role
2010 - Current Member of the BUSM Human Gene Therapy Committee
2010 - Current Member External Advisory Board Argentine Consortium on Stem Cells (CICEMA)
2006 - Current International Society for Stem Cell Research (ISSCR)
2011 - 2014 Member of the Boston University Institutional Animal Care and Use Committee (IACUC)
2008 - 2009 Member, the Boston University Institutional Biosafety Committee (IBC)
2002 - 2003 Member, American Society of Gene Therapy (ASGT)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
1996 - 2000 Teaching assistant, Department of Microbiology, The Hebrew University Jerusalem, Israel Microbiology The Hebrew University of Jerusalem, Israel
1991 - 1992 Teaching assistant, Department of Biology, University of Tucuman, Argentina Biology Universidad Nacional de Tucumán, Argentina
1991 - 1992 Teaching assistant, Genetics Section, University of Tucuman, Argentina Genetics Section Universidad Nacional de Tucumán, Argentina
1990 - 1991 Teaching assistant, Department of Microbiology, University of Tucuman, Argentina Microbiology Universidad Nacional de Tucumán, Argentina
Distinctions

Award

2019 CJD Foundation Research Awardee
2019 KY Cha Award in Stem Cell Technology
American Society for Reproductive Medicine Birmingham, United States
2019 Evans Outstanding Citizenship Award 2019 Dept. of Medicine BUSM
Boston University Department of Medicine, United States
2017 Innovator of the Year Award 2017 BU
Boston University School of Medicine, United States
2015 Fulbright Senior Specialist Scholar
UNITED STATES DEPARTMENT OF STATE, United States
2009 ARRA Challenge Award – NIH/NHLBI
National, Hearth, Lung, and Blood Institute, United States
2002 Lady Tata Memorial Trust. Postdoctoral Award.
Lady Tata Memorial Trust, United Kingdom
2000 Travel Allowance Fellowship from Boehringer Ingelheim Fonds.
Boehringer Ingelheim Fonds, Germany
1999 The Hebrew University Excellency Award as Teaching Assistant at the Department of Microbiology,
1995 Golda Meir Award
The Hebrew University of Jerusalem, Israel