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Ana Sofia Marques (ASM) completed her bachelor degree in Biotechnology in 2020 at University of Aveiro (UAVR). Her bachelor’s final project, entitled “Optimization of L-Asparaginase production by Bacillus subtilis”, was carried out at the Aveiro Institute of Materials (CICECO, UAVR). During this period, she had the opportunity to acquire scientific and technical knowledge in the production of enzymes by bacteria through fermentation and collaborated in writing a review article on L-asparaginase recombinant production processes (https://doi.org/10.1007/s00253-021-11359-y). Afterwards, she did a summer internship at Lusogenes company (Aveiro, Portugal) where she learned about genetic improvement using reproductive biotechnologies (artificial insemination and sperm preservation/cryopreservation). By the end of 2022, she completed her master degree in biotechnology, with specialization in Molecular Biotechnology and Bioengineering, at the same institution. During the first academic year of her Master, ASM carried out volunteer research activities at CICECO in a project related to studying the effect of deep eutectic solvents in the stability of immunoglobulin G antibodies, that resulted in the publication of one scientific article (http://dx.doi.org/10.1039/d2gc03415h). At the end of the first year of her master, she did a second summer internship at NeuroSoV (Covilhã, Portugal), where she had the opportunity to follow some in vivo studies and immunohistochemistry assays for developing a new molecule for Parkinson’s Disease. ASM then developed (CICECO, UAVR) her MSc thesis entitled “Purification and stability of antibodies using alternative materials and solvents”. During this period, she had the opportunity to acquire and consolidate scientific and technical skills in protein analysis methodologies (e.g., SE-HPLC and SDS-PAGE). Up to date, she is co-author of two scientific articles, one of them in the high impact journal Green Chemistry. During her academic path, ASM had the opportunity to disseminate the results of her research in two conferences and has participated in several workshops and webinars to expand her knowledge in different scientific domains. Recently, she won the competition for the best logo and it was chosen as the official logo for the UAVR-RNA Club and she was awarded with an one-year trainee membership in the RNA Society. After this period she was a Research Fellow at CICECO (UAVR), hired under the framework of a European Innovation Council-funded project (Yscript-Ref. 101047214). Her work focused the stabilization and extraction of bioproduced mRNA using biocompatible ionic liquids. In this context, she spent 3 months as a visiting researcher at the CBM-CNRS (Orléans, France). Currently, she is a PhD student, at the same research group, and her present research activities involve integrated separation-purification strategies of nucleic acids produced from recombinant technology.
Identification

Personal identification

Full name
Ana Sofia Correia Marques

Citation names

  • Ana S. C. Marques

Author identifiers

Ciência ID
A210-32D8-10DA
ORCID iD
0000-0001-5798-0917

Websites

Knowledge fields

  • Engineering and Technology - Industrial Biotechnology
  • Medical and Health Sciences - Medical Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Upper intermediate (B2)
Education
Degree Classification
2023/10/01 - 2027/09/30
Ongoing
Engenharia Química (Doutoramento)
Universidade de Aveiro, Portugal
2020 - 2022
Concluded
Biotecnologia (Mestrado)
Major in Molecular Biotechnology and Bioengineering
Universidade de Aveiro, Portugal
"Purification and stability of antibodies using alternative materials and solvents " (THESIS/DISSERTATION)
17
2017 - 2020
Concluded
Biotecnologia (Licenciatura)
Universidade de Aveiro, Portugal
"Optimization of L-Asparaginase production by bacillus subtilis" (THESIS/DISSERTATION)
15
Affiliation

Others

Category
Host institution
Employer
2023/10/01 - Current PhD Student Fundação para a Ciência e a Tecnologia, Portugal
2022/10/01 - 2023/09/30 Research Grant Universidade de Aveiro CICECO, Portugal
Universidade de Aveiro, Portugal
2023/01 - 2023/03 Visiting PhD Student Centre National de la Recherche Scientifique, France
Centre de Biophysique Moléculaire, France
2020 - 2022 Volunteer researcher Universidade de Aveiro CICECO, Portugal
Universidade de Aveiro, Portugal
2021/07 - 2021/08 Summer Internship - NeuroSov NeuroSov , Portugal
Universidade da Beira Interior, Portugal
2020/07 - 2020/09 Summer Internship - Lusogenes Lusogenes , Portugal
Projects

Contract

Designation Funders
2022/10/01 - 2023/10/01 Yscript- Yeast cell factory for mRNA bioproduction
BI/UI89/10423/2022
Research Fellow
Universidade de Aveiro CICECO, Portugal
Ongoing
Outputs

Publications

Conference poster
  1. Ana S. C. Marques; João L. P. Fernandes; Augusto Q. Pedro; Cristine Gonçalves; Ana P. M. Tavares; Chantal Pichon; Mara G. Freire. Corresponding author: Ana S. C. Marques. "Recovery of recombinant nucleic acid-based biopharmaceuticals using alternative solvents". Paper presented in 6th Meeting of Medicinal Biotechnology, 2024.
  2. Ana S. C. Marques; João L. P. Fernandes; Augusto Q. Pedro; Cristine Gonçalves; Ana P. M. Tavares; Ana Poim; Ana R. Soares; Chantal Pichon; Mara G. Freire. Corresponding author: Ana S. C. Marques. "Integrated extraction-preservation platforms of nucleic acid-based biopharmaceuticals using alternative solvents". Paper presented in VII iBiMED Symposium, 2024.
  3. Ana S. C. Marques; Augusto Q. Pedro; Cristine Gonçalves; Ana P. M. Tavares; Chantal Pichon; Mara G. Freire. "Ionic Liquids: An innovative cell disruption method for the extraction of nucleic acids-based biopharmaceuticals from yeast". Paper presented in MICROBIOTEC 2023 - Congress of Microbiology and Biotechnology, 2023.
  4. Ana S. C. Marques; Augusto Q. Pedro; Cristine Gonçalves; Ana P. M. Tavares; Chantal Pichon; Mara G. Freire. Corresponding author: Ana S. C. Marques. "Innovative use of Ionic Liquids for Extracting Nucleic Acid-Based Biopharmaceuticals from Yeast". Paper presented in Jornadas do CICECO 2023, 2023.
  5. Ana S. C. Marques; Augusto Q. Pedro; Cristine Gonçalves; Ana P. M. Tavares; Chantal Pichon; Mara G. Freire. Corresponding author: Ana S. C. Marques. "Development of an integrated process for the recovery and purification of recombinant messenger RNA vaccines resorting to bio-based ionic liquids". Paper presented in ChemPor 2023 – International Chemical and Biological Engineering Conference, 2023.
  6. Ana S. C. Marques; Diksha Dhiman; Meena Bisht; Ana P. M. Tavares; Mara G. Freire; Pannuru Venkatesu. Corresponding author: Ana S. C. Marques. "Potential of deep eutectic solvents to improve the conformational and colloidal stability of biopharmaceuticals". Paper presented in SPQ 2023- XXVIII Encontro Nacional da Sociedade Portuguesa de Química, 2023.
  7. Ana S. C. Marques; MÁRIO R. C. SOROMENHO; ANA P. M. TAVARES; MARA G. FREIRE; JOSÉ M. S. S. ESPERANÇA. "Purification of antibodies using alternative materials". Paper presented in 5th Meeting of Medicinal Biotechology, 2022.
  8. ANA S. C. MARQUES; MÁRIO R. C. SOROMENHO; ANA P. M. TAVARES; MARA G. FREIRE; JOSÉ M. S. S. ESPERANÇA. "Purification of antibodies using alternative materials". Paper presented in Jornadas CICECO 2022, 2022.
Journal article
  1. Diksha Dhiman; Ana S. C. Marques; Meena Bisht; Ana P. M. Tavares; Mara G. Freire; Pannuru Venkatesu. "Unveiling the potential of deep eutectic solvents to improve the conformational and colloidal stability of immunoglobulin G antibodies". Green Chemistry (2022): http://dx.doi.org/10.1039/d2gc03415h.
    10.1039/d2gc03415h
  2. Daniel Castro; Ana Sofia C. Marques; Mafalda R. Almeida; Gabriela B. de Paiva; Heitor B. S. Bento; Danielle B. Pedrolli; Mara G. Freire; Ana P. M. Tavares; Valéria C. Santos-Ebinuma. "L-asparaginase production review: bioprocess design and biochemical characteristics". Applied Microbiology and Biotechnology 105 11 (2021): 4515-4534. https://doi.org/10.1007/s00253-021-11359-y.
    10.1007/s00253-021-11359-y
Thesis / Dissertation
  1. "Purification and stability of antibodies using alternative materials and solvents". Master, 2022.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/10 Exploring novel solvents for enhanced conformational and colloidal stability of biopharmaceuticals. XXVII Encontro Luso-Galego de Química
(Porto, Portugal)
2023/08 Extraction strategies for developing recombinant messenger RNA vaccines resorting to biobased ionic liquids. Research Summit
Universidade de Aveiro (Aveiro, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2024/06/19 - 2024/06/19 AIM Further- "Where will the future take me? Academia vs Insdustry" (2024/08/19 - 2024/08/19)
Meeting (Co-organisor)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2022/10/21 - Current Participation in the 5th Meeting of Medicinal Biotechnology 5th Meeting of Medicinal Biotechnology
2023/03/22 - 2023/03/23 Attendance to the meeting "Yeast cell factory for mRNA bioproduction - Kick-off Meeting"
Universidade de Aveiro, Portugal
2022/12/16 - 2022/12/16 Attendance to the webinar entitle "Sexagem de sémen: Aplicações na Produção Animal"
2022/10/19 - 2022/10/19 Attendance at the workshop entitled "Modern Data Exploration and Design of Experiments"
2022/10/12 - 2022/10/12 Participation in the Jornadas CICECO 2022 Jornadas CICECO 2022
Universidade de Aveiro CICECO, Portugal
2022/06/02 - 2022/06/02 Attendance to PATh/IL2BioPro/mVACCIL Workshop: Leading strategies in biopharmaceuticals manufacturing
2021/09/30 - 2021/09/30 Attendance to 6th PATh Spring Workshop: A Path Towards Biomass Valorization Assisted by Green Chemistry Tools

Committee member

Activity description
Role
Institution / Organization
2023/10/01 - Current PhD Student Committee (CAD) at CICECO - Aveiro Institute of Materials, University of Aveiro
Member
Universidade de Aveiro CICECO, Portugal
Distinctions

Award

2023 Official logo for UAVR-RNAClub - RNA Society 1-year membership
Universidade de Aveiro, Portugal