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Identification

Personal identification

Full name
Luís Cirnes

Citation names

  • Cirnes, Luís
  • Cirnes L.

Author identifiers

Ciência ID
A412-0AC5-0780
ORCID iD
0000-0002-2348-5878
Education
Degree Classification
2013 - 2014
Concluded
 Título de Especialista em Anatomia Patológica (Título de especialista)
Major in Anatomia Patológica
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
2007 - 2009
Concluded
 Medicina Legal (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Muito bom
2006 - 2007
Concluded
 Pós-Graduação em Ciências Médico-Legail (Pós-Graduação)
Major in Medicina Legal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 16
2000 - 2001
Concluded
 Anatomia Patológica, Citológica e Tanatológica (Anatomia Patológica, Citológica e Tanatológica (Licenciatura)
Major in Anatomia Patológica
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
1993 - 1996
Concluded
 Bacharelato em Anatomia Patológica, Citológica e Tanatológica (Anatomia Patológica, Citológica e Tanatológica) (Bacharelato)
Major in Anatomia Patológica
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
 16
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2014 - 2024 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
2014 - 2019 Invited Assistant (Polytechnic Teacher) Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
2007 - 2014 Assistant (Polytechnic Teacher) Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal

Positions / Appointments

Category
Host institution 		Employer
1996 - 2023 Técnico Coordenador Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Outputs

Publications

Book review
  1. Pinto, Daniel; Cirnes, Luís; Regina Pinto, Pinto; Pina, Maria João; Troncone, Giancarlo; Schmitt, Fernando. "How the COVID-19 Pandemic Impacted Oncological Molecular Diagnosis". http://hdl.handle.net/10362/106131.
    https://doi.org/10.1155/2020/8397053
Conference paper
  1. Baixia, Márcia; Sousa, Sónia; Pina, Maria J.; Silva, Raquel M; Cirnes, Luis; Canedo, Paulo; Castedo, Sérgio; Machado, José C,. "The bigger the better? Evaluation of the value of large multi-gene panels in Portuguese cardiomyopathy genetic testing". 2019.
  2. Moura, Daniela; Pina, Maria João; Pereira, Cátia; Baixia, Márcia; Leal, Rafaela; Sousa, Sónia; Vieira, Filipa Quintela; Silva, Regina; Cirnes, Luís. "Impact of different storage conditions of formamide in the quality of sequences". 2015.
  3. Moura, Daniela; Pina, Maria João; Pereira, Cátia; Baixia, Márcia; Leal, Rafaela; Sousa, Sónia; Vieira, Filipa Quintela; Silva, Regina; Cirnes, Luís. "Effects of different storage conditions of sequencing products with formamide in the quality of sequences.". 2015.
Journal article
  1. Diogo Marques; Irene Gullo; Luís Mascarenhas-Lemos; João Ricardo Silva; Catarina Neto do Nascimento; Patrícia Pontes; Lídia Pinho; et al. "Performance of Immunohistochemical and Molecular Methods in Detecting Microsatellite Instability in Gastric Cancer: A Multicenter Study". Pathobiology (2023): 1-11. http://dx.doi.org/10.1159/000530997.
    10.1159/000530997
  2. Marina Morais; Telma Fonseca; Diogo Melo-Pinto; Isabel Prieto; Ana Teresa Vilares; Ana Luísa Duarte; Patrícia Leitão; et al. "Evaluation of ctDNA in the Prediction of Response to Neoadjuvant Therapy and Prognosis in Locally Advanced Rectal Cancer Patients: A Prospective Study". Pharmaceuticals 16 3 (2023): 427-427. http://dx.doi.org/10.3390/ph16030427.
    10.3390/ph16030427
  3. Ana Peixoto; Luís Cirnes; Ana Luísa Carvalho; Maria João Andrade; Maria José Brito; Paula Borralho; Pedro M. Borralho; et al. "Evaluation of PIK3CA mutations in advanced ER+/HER2-breast cancer in Portugal – U-PIK Project". Frontiers in Molecular Biosciences 10 (2023): http://dx.doi.org/10.3389/fmolb.2023.1082915.
    10.3389/fmolb.2023.1082915
  4. Umberto Malapelle; Francesco Pepe; Pasquale Pisapia; Annalisa Altimari; Claudio Bellevicine; Hans Brunnström; Rossella Bruno; et al. "Reference standards for gene fusion molecular assays on cytological samples: an international validation study". Journal of Clinical Pathology 76 1 (2023): 47-52. http://dx.doi.org/10.1136/jclinpath-2021-207825.
    10.1136/jclinpath-2021-207825
  5. Gabriela Fernandes; Ana Rodrigues; Cláudia Matos; Fernando Barata; Luís Cirnes; Lurdes Ferreira; José Albino Lopes; et al. "Liquid biopsy in the management of advanced lung cancer: Implementation and practical aspects". Cancer Treatment and Research Communications 36 (2023): 100725-100725. http://dx.doi.org/10.1016/j.ctarc.2023.100725.
    10.1016/j.ctarc.2023.100725
  6. Silva, João R.; Mascarenhas-Lemos, Luís; Neto do Nascimento, Catarina; Sousa Marques, Diogo; Wen, Xiaogang; Pinho, Lídia; Maio, Rui; et al. "Role of endoscopic biopsies and morphologic features in predicting microsatellite instability status in gastric cancer". (2023): http://hdl.handle.net/10451/59231.
    10.1097/PAS.0000000000002085
  7. Ricella Souza da Silva; Regina Pinto; Luis Cirnes; Fernando Schmitt. "Tissue management in precision medicine: What the pathologist needs to know in the molecular era". Frontiers in Molecular Biosciences 9 (2022): http://dx.doi.org/10.3389/fmolb.2022.983102.
    10.3389/fmolb.2022.983102
  8. Margarida Costa e Silva; I. Sucena; L. Cirnes; Jose Carlos Machado; S. Campainha; Ana Paixão Barroso. "KIF5B-MET fusion variant in non-small cell lung cancer". Pulmonology 28 4 (2022): 315-316. http://dx.doi.org/10.1016/j.pulmoe.2022.02.001.
    10.1016/j.pulmoe.2022.02.001
  9. Irene Gullo; Ana Marques; Regina Pinto; Luis Cirnes; Schmitt F.. "Morphological control for molecular testing: a practical approach". Journal of Clinical Pathology 74 5 (2021): 331-333. http://dx.doi.org/10.1136/jclinpath-2020-206890.
    10.1136/jclinpath-2020-206890
  10. Élia Cipriano; Helena Magalhães; Catarina Tavares; João Pinto; Luís Cirnes; Fernanda Estevinho. "Concurrent EGFR mutation and ALK rearrangement in stage IV lung adenocarcinoma—a case report and a literature review". Porto Biomedical Journal 6 1 (2021): e124-e124. http://dx.doi.org/10.1097/j.pbj.0000000000000124.
    10.1097/j.pbj.0000000000000124
  11. Maria Gabriela O. Fernandes; Catarina Sousa; Maria Jacob; Leonor Almeida; Vanessa Santos; David Araújo; Hélder Novais Bastos; et al. "Resistance profile of osimertinib in pre-treated patients with EGFR T790M-mutated non-small cell lung cancer". (2021): https://hdl.handle.net/10216/144336.
    10.3389/fonc.2021.602924
  12. D. Reis; C. Marques; M. Dias; S. Campainha; L. Cirnes; A. Barroso. "Mutational profile of non-small cell lung cancer patients: Use of next-generation sequencing". Pulmonology 26 1 (2020): 50-53. http://dx.doi.org/10.1016/j.pulmoe.2019.05.003.
    10.1016/j.pulmoe.2019.05.003
  13. Pinto, Daniel; Cirnes, Luís; Pinto, Regina; Pina, Maria João; Giancarlo, Troncone; Schimitt, Fernando. "How the COVID-19 Pandemic Impacted Oncological Molecular Diagnosis: A Picture from a National Reference Center for Molecular Pathology". (2020): http://hdl.handle.net/10400.22/16620.
    10.1155/2020/8397053
  14. Fernandes, Maria Gabriela O.; Jacob, Maria; Martins, Natália; Moura, Conceição Souto; Guimarães, Susana; Pereira Reis, Joana; Justino, Ana; et al. "Targeted Gene Next-Generation Sequencing Panel in Patients with Advanced Lung Adenocarcinoma: Paving the Way for Clinical Implementation". (2019): http://hdl.handle.net/10400.22/14843.
    10.3390/cancers11091229
  15. Filipa Aguiar; Gabriela Fernandes; Henrique Queiroga; José Carlos Machado; Luís Cirnes; Conceição Souto Moura; Venceslau Hespanhol. "Overall Survival Analysis and Characterization of an EGFR Mutated Non-Small Cell Lung Cancer (NSCLC) Population". Archivos de Bronconeumología 54 1 (2018): 10-17. http://dx.doi.org/10.1016/j.arbres.2017.07.012.
    10.1016/j.arbres.2017.07.012
  16. J. Azevedo; A. Pista; C. Lisboa; I. Santo; L. Azevedo; M.J. Cunha; the HERCOLES Study Group. "Epidemiology of human papillomavirus on anogenital warts in Portugal – The HERCOLES study". Journal of the European Academy of Dermatology and Venereology 31 8 (2017): 1342-1348. http://dx.doi.org/10.1111/jdv.14311.
    10.1111/jdv.14311
  17. Helena Maria Melo Torcato Barroca; Luis Cirnes; José Manuel Lopes. "Metanephric adenoma: Cytological, histological, and molecular diagnosis of a case". Diagnostic Cytopathology 44 3 (2016): 263-266. http://dx.doi.org/10.1002/dc.23427.
    10.1002/dc.23427
  18. Ana Justino; Patrícia Dias; Maria João Pina; Sónia Sousa; Luís Cirnes; Ana Berta Sousa; José Carlos Machado; Jose Luis Costa. "Comprehensive massive parallel DNA sequencing strategy for the genetic diagnosis of the neuro-cardio-facio-cutaneous syndromes". European Journal of Human Genetics 23 3 (2015): 347-353. http://dx.doi.org/10.1038/ejhg.2014.97.
    10.1038/ejhg.2014.97
  19. Veiga, Nélio; Pereira, Carlos; Resende, Carlos; Amaral, Odete; Ferreira, Manuela; Nelas, Paula; Chaves, Claudia; et al. "Oral and gastric helicobacter pylori: effects and associations". (2015): http://hdl.handle.net/10400.14/33939.
    10.1371/journal.pone.0126923
  20. Esther D. Rossi; Renê Gerhard; Luis Cirnes; José Carlos Machado; Fernando Schmitt. "Detection of Common and Less Frequent <b><i>EGFR</i></b> Mutations in Cytological Samples of Lung Cancer". Acta Cytologica 58 3 (2014): 275-280. http://dx.doi.org/10.1159/000363174.
    10.1159/000363174
  21. José Luis Costa; Sónia Sousa; Ana Justino; Teresa Kay; Susana Fernandes; Luis Cirnes; Fernando Schmitt; José Carlos Machado. "Nonoptical Massive Parallel DNA Sequencing ofBRCA1andBRCA2Genes in a Diagnostic Setting". Human Mutation 34 4 (2013): 629-635. http://dx.doi.org/10.1002/humu.22272.
    10.1002/humu.22272
  22. Carla Pinto; Isabel Veiga; Manuela Pinheiro; Ana Peixoto; Armando Pinto; José M. Lopes; Rui M. Reis; et al. "TP53 germline mutations in Portugal and genetic modifiers of age at cancer onset". Familial Cancer 8 4 (2009): 383-390. http://dx.doi.org/10.1007/s10689-009-9251-y.
    10.1007/s10689-009-9251-y
  23. Angélica C. Bertagnolli; Paula Soares; Bárbara van Asch; António Amorim; Luis Cirnes; Valdemar Máximo; Geovanni D. Cassali. "An assessment of the clonality of the components of canine mixed mammary tumours by mitochondrial DNA analysis". The Veterinary Journal 182 2 (2009): 269-274. http://dx.doi.org/10.1016/j.tvjl.2008.07.005.
    10.1016/j.tvjl.2008.07.005
  24. Sérgia Velho; Cátia Moutinho; Luís Cirnes; Cristina Albuquerque; Richard Hamelin; Fernando Schmitt; Fátima Carneiro; Carla Oliveira; Raquel Seruca. "BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?". BMC Cancer 8 1 (2008): http://dx.doi.org/10.1186/1471-2407-8-255.
    10.1186/1471-2407-8-255
  25. Mafalda Pinto; Ying Wu; Rob G.J. Mensink; Luís Cirnes; Raquel Seruca; Robert M.W. Hofstra. "Somatic mutations in mismatch repair genes in sporadic gastric carcinomas are not a cause but a consequence of the mutator phenotype". Cancer Genetics and Cytogenetics 180 2 (2008): 110-114. http://dx.doi.org/10.1016/j.cancergencyto.2007.09.022.
    10.1016/j.cancergencyto.2007.09.022
  26. G. Corso; F. Roviello; J. Paredes; C. Pedrazzani; M. Novais; J. Correia; D. Marrelli; et al. "Characterization of the P373L E-cadherin germline missense mutation and implication for clinical management". European Journal of Surgical Oncology (EJSO) 33 9 (2007): 1061-1067. http://dx.doi.org/10.1016/j.ejso.2007.03.001.
    10.1016/j.ejso.2007.03.001
  27. Ana Margarida Meireles; Ana Preto; Ana Sofia Rocha; Ana Paula Rebocho; Valdemar Máximo; Isabel Pereira-Castro; Severina Moreira; et al. "Molecular and Genotypic Characterization of Human Thyroid Follicular Cell Carcinoma–Derived Cell Lines". Thyroid 17 8 (2007): 707-715. http://dx.doi.org/10.1089/thy.2007.0097.
    10.1089/thy.2007.0097
  28. V Davalos; H Dopeso; S Velho; A M Ferreira; L Cirnes; N Díaz-Chico; C Bilbao; et al. "High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability". Oncogene 26 2 (2007): 308-311. http://dx.doi.org/10.1038/sj.onc.1209780.
    10.1038/sj.onc.1209780
  29. C Carrilho. "Distribution of HPV infection and tumour markers in cervical intraepithelial neoplasia from cone biopsies of Mozambican women". Journal of Clinical Pathology 58 1 (2005): 61-68. http://dx.doi.org/10.1136/jcp.2004.020552.
    10.1136/jcp.2004.020552
  30. Ralph Carvalho; Anya NA Milne; Bastiaan P van Rees; Eric Caspers; Luís Cirnes; Céu Figueiredo; G Johan A Offerhaus; Marian AJ Weterman. "Early-onset gastric carcinomas display molecular characteristics distinct from gastric carcinomas occurring at a later age". The Journal of Pathology 204 1 (2004): 75-83. http://dx.doi.org/10.1002/path.1602.
    10.1002/path.1602
  31. Carla Oliveira; Paulo Ferreira; Sérgio Nabais; Luisa Campos; Ana Ferreira; Lui´s Cirnes; Catarina Castro Alves; et al. "E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients". European Journal of Cancer 40 12 (2004): 1897-1903. http://dx.doi.org/10.1016/j.ejca.2004.04.027.
    10.1016/j.ejca.2004.04.027
  32. Philip R Debruyne; Stefan J Vermeulen; Geert Berx; Marc Pocard; Ana-Sofia Correia da Rocha; Xuedong Li; Luis Cirnes; et al. "Functional and molecular characterization of the epithelioid to round transition in human colorectal cancer LoVo cells". Oncogene 22 46 (2003): 7199-7208. http://dx.doi.org/10.1038/sj.onc.1206628.
    10.1038/sj.onc.1206628
  33. B Carvalho; M Pinto; L Cirnes; C Oliveira; J.C Machado; G Suriano; R Hamelin; F Carneiro; R Seruca. "Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas". European Journal of Cancer 39 9 (2003): 1222-1227. http://dx.doi.org/10.1016/s0959-8049(03)00177-1.
    10.1016/s0959-8049(03)00177-1
  34. Mafalda Pinto; Carla Oliveira; Luis Cirnes; Jos¿ Carlos Machado; Maria Ramires; Ana Nogueira; F¿tima Carneiro; Raquel Seruca. "Promoter methylation of TGF? receptor I and mutation of TGF? receptor II are frequent events in MSI sporadic gastric carcinomas". The Journal of Pathology 200 1 (2003): 32-38. http://dx.doi.org/10.1002/path.1327.
    10.1002/path.1327
  35. Helena Barroca; José Luis Carvalho; Maria João Gil da Costa; Luis Cirnes; Raquel Seruca; Fernando C. Schmitt. "Detection of <i>N-myc</i> Amplification in Neuroblastomas Using Southern Blotting on Fine Needle Aspirates". Acta Cytologica 45 2 (2001): 169-173. http://dx.doi.org/10.1159/000327272.
    10.1159/000327272
  36. Mafalda Pinto; Carla Oliveira; José Carlos Machado; Luis Cirnes; João Tavares; Fátima Carneiro; Richard Hamelin; et al. "MSI-L Gastric Carcinomas Share the hMLH1 Methylation Status of MSI-H Carcinomas but Not Their Clinicopathological Profile". Laboratory Investigation 80 12 (2000): 1915-1923. http://dx.doi.org/10.1038/labinvest.3780201.
    10.1038/labinvest.3780201
  37. Nogueira AM; Carneiro F; Raquel Seruca; Cirnes L; Veiga I; Jose Carlos Machado; Sobrinho-Simões M. "Microsatellite instability in hyperplastic and adenomatous polyps of the stomach.". Cancer (1999): https://doi.org/10.1002/(SICI)1097-0142(19991101)86:9<1649::AID-CNCR5>3.0.CO;2-N.
    10.1002/(sici)1097-0142(19991101)86:9<1649::aid-cncr5>3.0.co;2-n
  38. Fernando C. Schmitt; Raquel Soares; Helenice Gobbi; Fernanda Milanezzi; Filipe Santos-Silva; Luis Cirnes; Carla Costa; Raquel Seruca. "Microsatellite instability in medullary breast carcinomas". International Journal of Cancer 82 5 (1999): 644-647. http://dx.doi.org/10.1002/(sici)1097-0215(19990827)82:5<644::aid-ijc5>3.0.co;2-s.
    10.1002/(sici)1097-0215(19990827)82:5<644::aid-ijc5>3.0.co;2-s
  39. Lopes; Silva; Seixas; Cirnes; Seruca. "Microsatellite instability is not associated with degree of malignancy and p53 expression of gastrointestinal stromal tumours". Histopathology 33 6 (1998): 583-585. http://dx.doi.org/10.1046/j.1365-2559.1998.0525d.x.
    10.1046/j.1365-2559.1998.0525d.x
  40. Fernando Carlos Schmitt; Raquel Soares; Luis Cirnes; Raquel Seruca. "PCR amplification of DNA obtained from archived hematoxylin-eosin– and giemsa-stained breast cancer aspirates". Diagnostic Cytopathology 19 5 (1998): 395-397. http://dx.doi.org/10.1002/(sici)1097-0339(199811)19:5<395::aid-dc19>3.0.co;2-4.
    10.1002/(sici)1097-0339(199811)19:5<395::aid-dc19>3.0.co;2-4
Thesis / Dissertation
  1. Gouveia, Ana Maria Furtado. "Transcripts as modifiers of phenotypic variability in hereditary transthyretin-mediated amyloidosis biopsies". Master, 2022. http://hdl.handle.net/10400.22/21749.
  2. Cardoso, Luís Augusto Cirnes. ""Miocardiopatias associadas à morte súbita".". Master, 2011. http://hdl.handle.net/10216/22354.

Other

Other output
  1. Caracterização molecular do gene EGFR em pacientes com NSCLC. Trabalho para obtenção do Título de Especialista em Anatomia Patológica, Citológica e Tanatológica. 2013. Cirnes, Luís. http://hdl.handle.net/10400.22/14751.