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Identification

Personal identification

Full name
Ana Rita Malheiro

Citation names

  • Malheiro, Ana

Author identifiers

Ciência ID
A511-DF75-D15F
ORCID iD
0000-0002-9093-5875

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
Education
Degree Classification
2019/07/16
Concluded
 Biologia Molecular e Celular (Doutoramento)
Major in Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Uncover the duality of neuronal and glial dysfunctions in the neuropathogenesis of plasmalogen deficiency " (THESIS/DISSERTATION)
 Aprovado
2012
Concluded
 Mestrado em Terapias Moleculares (Mestrado)
Instituto Superior de Ciências da Saúde - Norte, Portugal
"The role of plasmalogens in the formation and maintenance of myelin in the central nervous system" (THESIS/DISSERTATION)
 17
2010
Concluded
 Anatomia Patológica, Citológica e Tanatológica (Licenciatura)
Escola Superior de saúde do Vale do Sousa - Instituto Politécnico de Saúde do Norte, CESPU, Portugal
"Biópsia do Nódulo Linfático Sentinela em adolescentes com Melanoma e outros tumores melanocíticos" (THESIS/DISSERTATION)
 16
Affiliation

Other Careers

Category
Host institution 		Employer
2017/12/01 - Current Técnico Superior (Técnico Superior) Instituto de Biologia Molecular e Celular, Portugal
Instituto de Biologia Molecular e Celular, Portugal

Others

Category
Host institution 		Employer
2013/09/06 - 2019/07/16 PhD student in the Doctoral Program in Molecular and Cell Biology Universidade do Porto Faculdade de Ciências, Portugal
2014/02/01 - 2017/11/30 PhD Fellow: SFRH/BD/93110/2013 Instituto de Biologia Molecular e Celular, Portugal
2013/02/01 - 2014/01/31 Research Fellow: PTDC/SAU-GMG/111761/2009-BIM-I Instituto de Biologia Molecular e Celular, Portugal
2012/10/01 - 2013/01/31 Research Fellow: PTDC/SAU-GMG/111761/2009-BIL-I Instituto de Biologia Molecular e Celular, Portugal
2011/04/01 - 2012/09/30 Technician: IBMC-ELA 042C5 Instituto de Biologia Molecular e Celular, Portugal
2010/09/01 - 2011/02/28 Monitor de estágio da unidade curricular - Estágio de Aprendizagem I - da Licenciatura em Anatomia Patológica, Citológica e Tanatológica Instituto Politécnico de Saúde do Norte, Portugal
Projects

Contract

Designation Funders
2018/07/01 - 2021/06/30 Determinação da neuropatologia por detrás de uma deficiência em plasmalogénios: consequências, mecanismos e terapia.
PTDC/MED-PAT/30558/2017
Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/02/01 - 2019/03/31 Identificação de terapias farmacológicas para doenças da biogénese dos peroxissomas.
E-Rare3/0001/2015
Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/02/01 - 2017/11/30 Não disponível
SFRH/BD/93110/2013
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Mendes, N.; Dias Carvalho, P.; Martins, F.; Mendonça, S.; Malheiro, A. R.; Ribeiro, A.; Carvalho, J.; Velho, S.. "Animal Models to Study Cancer and Its Microenvironment". In Advances in Experimental Medicine and Biology, 389-401. Springer International Publishing, 2020.
    10.1007/978-3-030-34025-4_20
Journal article
  1. Melo, Joana; Pinto, Vanessa; Fernandes, Tânia; Malheiro, Ana R.; Osório, Hugo; Figueiredo, Ceu; Leite, Marina. "Isolation Method and Characterization of Outer Membranes Vesicles of Helicobacter pylori Grown in a Chemically Defined Medium". Frontiers in Microbiology 12 (2021): http://dx.doi.org/10.3389/fmicb.2021.654193.
    10.3389/fmicb.2021.654193
  2. Rodrigues, Ana I.; Gudiña, Eduardo J.; Abrunhosa, Luís; Malheiro, Ana R.; Fernandes, Rui; Teixeira, José A.; Rodrigues, Lígia R.. "Rhamnolipids inhibit aflatoxins production in Aspergillus flavus by causing structural damages in the fungal hyphae and down-regulating the expression of their biosynthetic genes". International Journal of Food Microbiology 348 (2021): 109207. http://dx.doi.org/10.1016/j.ijfoodmicro.2021.109207.
    10.1016/j.ijfoodmicro.2021.109207
  3. Santos-Ferreira, Nânci; Alves, Ângela; Cardoso, Maria João; Langsrud, Solveig; Malheiro, Ana Rita; Fernandes, Rui; Maia, Rui; et al. "Cross-contamination of lettuce with Campylobacter spp. via cooking salt during handling raw poultry". PLOS ONE 16 5 (2021): e0250980. http://dx.doi.org/10.1371/journal.pone.0250980.
    10.1371/journal.pone.0250980
  4. Fertuzinhos, Aureliano Costa; Teixeira, Marta Albertina; Ferreira, Miguel Gonçalves; Fernandes, Rui; Correia, Rossana; Malheiro, Ana Rita; Flores, Paulo; Zille, Andrea; Dourado, N.. "Thermo-mechanical behaviour of human nasal cartilage". (2020): http://hdl.handle.net/1822/63109.
    10.3390/polym12010177
  5. Malheiro, Ana R.; Correia, Barbara; Ferreira da Silva, Tiago; Bessa-Neto, Diogo; Van Veldhoven, Paul P.; Brites, Pedro. "Leukodystrophy caused by plasmalogen deficiency rescued by glyceryl 1-myristyl ether treatment". Brain Pathology 29 5 (2019): 622-639. http://dx.doi.org/10.1111/bpa.12710.
    10.1111/bpa.12710
  6. Shinde, Abhijit Babaji; Baboota, Ritesh Kumar; Denis, Simone; Loizides-Mangold, Ursula; Peeters, Annelies; Espeel, Marc; Malheiro, Ana Rita; et al. "Mitochondrial disruption in peroxisome deficient cells is hepatocyte selective but is not mediated by common hepatic peroxisomal metabolites". Mitochondrion 39 (2018): 51-59. http://dx.doi.org/10.1016/j.mito.2017.08.013.
    10.1016/j.mito.2017.08.013
  7. De Munter, Stephanie; Bamps, Dorien; Malheiro, Ana Rita; Kumar Baboota, Ritesh; Brites, Pedro; Baes, Myriam. "Autonomous Purkinje cell axonal dystrophy causes ataxia in peroxisomal multifunctional protein-2 deficiency". Brain Pathology 28 5 (2018): 631-643. http://dx.doi.org/10.1111/bpa.12586.
    10.1111/bpa.12586
  8. De Munter, Stephanie; Verheijden, Simon; Vanderstuyft, Esther; Malheiro, Ana Rita; Brites, Pedro; Gall, David; Schiffmann, Serge N.; Baes, Myriam. "Early-onset Purkinje cell dysfunction underlies cerebellar ataxia in peroxisomal multifunctional protein-2 deficiency". Neurobiology of Disease 94 (2016): 157-168. http://dx.doi.org/10.1016/j.nbd.2016.06.012.
    10.1016/j.nbd.2016.06.012
  9. Malheiro, Ana R.; da Silva, Tiago Ferreira; Brites, Pedro. "Plasmalogens and fatty alcohols in rhizomelic chondrodysplasia punctata and Sjögren-Larsson syndrome". Journal of Inherited Metabolic Disease 38 1 (2014): 111-121. http://dx.doi.org/10.1007/s10545-014-9795-3.
    10.1007/s10545-014-9795-3
  10. Teixeira, Carla Andreia; Miranda, Catarina Oliveira; Sousa, Vera Filipe; Santos, Telma Emanuela; Malheiro, Ana Rita; Solomon, Melani; Maegawa, Gustavo H.; Brites, Pedro; Sousa, Mónica Mendes. "Early axonal loss accompanied by impaired endocytosis, abnormal axonal transport, and decreased microtubule stability occur in the model of Krabbe's disease". Neurobiology of Disease 66 (2014): 92-103. http://dx.doi.org/10.1016/j.nbd.2014.02.012.
    10.1016/j.nbd.2014.02.012
  11. da Silva, Tiago Ferreira; Eira, Jessica; Lopes, André T.; Malheiro, Ana R.; Sousa, Vera; Luoma, Adrienne; Avila, Robin L.; et al. "Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination". Journal of Clinical Investigation 124 6 (2014): 2560-2570. http://dx.doi.org/10.1172/jci72063.
    10.1172/jci72063
  12. da Silva, Tiago Ferreira; Sousa, Vera F.; Malheiro, Ana R.; Brites, Pedro. "The importance of ether-phospholipids: A view from the perspective of mouse models". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1822 9 (2012): 1501-1508. http://dx.doi.org/10.1016/j.bbadis.2012.05.014.
    10.1016/j.bbadis.2012.05.014
  13. Brites, Pedro; Ferreira, Ana Sofia; Ferreira da Silva, Tiago; Sousa, Vera F.; Malheiro, Ana R.; Duran, Marinus; Waterham, Hans R.; Baes, Myriam; Wanders, Ronald J. A.. "Alkyl-Glycerol Rescues Plasmalogen Levels and Pathology of Ether-Phospholipid Deficient Mice". PLoS ONE 6 12 (2011): e28539. http://dx.doi.org/10.1371/journal.pone.0028539.
    10.1371/journal.pone.0028539
Thesis / Dissertation
  1. Ana Rita Alves Malheiro. "Uncover the duality of neuronal and glial dysfunctions in the neuropathogenesis of plasmalogen deficiency". PhD, 2019. https://hdl.handle.net/10216/121569.
  2. Malheiro, Ana Rita Alves. "The role of plasmalogens in the formation and maintenance of myelin in the central nervous system". Master, 2012. https://repositorio.cespu.pt/handle/20.500.11816/231.
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/11/12 - 2021/11/12 V Technical Meeting of Electron Microscopy: Energy dispersive X-ray spectroscopy (EDS) analysis with SEM and TEM: How does it work? (2021/11/12 - 2021/11/12) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto de Biologia Molecular e Celular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/11/12 - 2021/11/12 V Technical Meeting of Electron Microscopy: Energy dispersive X-ray spectroscopy (EDS) analysis with SEM and TEM: How does it work?
Meeting
 V Technical Meeting of Electron Microscopy
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto de Biologia Molecular e Celular, Portugal
2020/02/09 - 2020/02/14 A Practical Approach to CLEM: The school is targeting users who are interested in establishing Correlative Light and Electron Microscopy (CLEM) in their home laboratories, but who may have limited technical resources and training in this area.
Other
 A Practical Approach to CLEM
Instituto Gulbenkian de Ciência, Portugal
2019/11/11 - 2019/11/11 Participation at “IV Technical meeting of Electron Microscopy”, at the Faculty of Medicine of the University of Coimbra, Portugal.
Meeting
 IV Technical meeting of Electron Microscopy
Faculdade de Medicina - Universidade de Coimbra, Portugal
2019/01/28 - 2019/01/31 Trained and certified at “Basic course cryosectioning and Immuno-gold labeling of thawed frozen sections (Tokuyasu technique)”, organized by the Cell Microscopy core, Utrecht, The Netherlands
Other
 Basic course cryosectioning and Immuno-gold labeling
Cell Microscopy core, Utrecht, The Netherlands, Netherlands
2011/05 - 2011/05 Trained and certified at level B from the Instituto de Ciências Biomédicas Abel Salazar (ICBAS) on animal handling and welfare according to FELASA requirements
Other
 Ciência em animais de laboratório - Categoria B
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2010/09/01 - 2011/02/28 Stage monitor of the curricular unit - Estágio de Aprendizagem I - da Licenciatura em Anatomia Patológica, Citológica e Tanatológica - Instituto Politécnico de Saúde do Norte Licenciatura em Anatomia Patológica, Citológica e Tanatológica (Licenciatura) Instituto Politécnico de Saúde do Norte, Portugal
Distinctions

Other distinction

2011 Best student 2009/2010