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Alain Morais, BSc in Medical laboratory technology in 2000 and MSc in Biomedical Sciences in 2004, completed his PhD degree in Biomedical and Pharmaceutical Sciences in 2009. All educational formation obtained from the Université Catholique de Louvain (UCL), Belgium. The academic formation also includes a MAS in Biomedical Sciences and the FELASA/ICLAS (category C). During his academic course, A. Morais published 4 original papers and 1 review (cumulative impact factor of 41 and over 525 citations). He also participated in several national and international meetings with oral and posters presentations. All participations in international congress were granted by full EASL Young Investigators Bursaries. During his PhD, A. Morais has also joined the Interuniversity Gastroenterology Exchange program sponsored by SOLVAY PHARMA. After his PhD A. Morais moved to Portugal and, between January 2010 and December 2011, worked as post-doc at University of Minho (CBMA) granted by FCT (SFRH/BPD/62856/2009). The results obtained showed, for the first time, the existence of an EGFR protein paralog in yeast cell surface. During few months, he worked in France in the pharmaceutical company Macors as one of the responsible for the quality control of the main company¿s product: Movicol. This experience allowed him to enlarge his skills. On March 2013, A. Morais was hired as post-doc by the 3B's Research Group. Since then, A. Morais has worked closely with Stemmatters Company in the development of new ATMP for cartilage tissue engineering (TE) resulting in the submission of two patents and several oral and poster communications in national and international congress. With more than 19 scientific contributions in scientific journals with referee (most of them in high impact factor journals), participation in 2 patents, 6 book chapters in books with international circulation, A. Morais has an h-index of 14, receiving over 850 citations; and a RG of 28.74. Recently he was strongly involved in the FEDER-funded 3BioMeD project (FCT/4773/4/5/2017/S - €99.810,00 M) as well as on B-Liver project (2017 Call for SR&TD Project Grant - €238.601,47). At 3B's, the applicant has been involved on the field of biomaterials for biomedical applications and new in vivo models, namely for TE and orthopedics, with applications mainly directed to cartilage lesions. More recently, A. Morais has been involved on TE applications for meniscus, pancreas, liver and nerve conduct. As post-doc, he co-supervises unofficially the work of several PhD students.
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Identification

Personal identification

Full name
Alain José da Silva Morais

Citation names

  • da Silva Morais, Alain

Author identifiers

Ciência ID
A513-378B-3139
ORCID iD
0000-0001-5057-0819

Email addresses

  • alain.morais@i3bs.uminho.pt (Professional)

Addresses

  • 3B's Research Group - Department of Polymer Engineering - University of Minho. Avepark - Parque de Ciência e Tecnologia - Zona Industrial da Gandra, 4805-017, Barco - Guimarães, Guimarães, Portugal (Professional)

Websites

Languages

Language Speaking Reading Writing Listening Peer-review
French Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2009/02/25
Concluded
 PhD in Biomedical and Pharmaceutical Sciences (Docteur)
Université catholique de Louvain Secteur des sciences de la santé, Belgium
"Role of the cascade PPARgamma - Adiponectin - AMPK in the control of hepatic fibrogenesis and steatohepatitis." (THESIS/DISSERTATION)
 Grande distinção
2008/06/30
Concluded
 FELASA category C compulsory courses in laboratory animal science (Postgraduate Certificate)
Université catholique de Louvain Secteur des sciences de la santé, Belgium
"n/a" (THESIS/DISSERTATION)
 Distinção
2007/09/01
Concluded
 DES (DEA)
Université catholique de Louvain Secteur des sciences de la santé, Belgium
"PPARgamma agonist, Pioglitazone, does not prevent hepatic fibrosis in mice" (THESIS/DISSERTATION)
 Grande distinção
2004/09/09
Concluded
 Ciências biomédicas e experimentais (Licence)
Université catholique de Louvain Secteur des sciences de la santé, Belgium
"Impact of the inhibition of the Ras oncoprotein on the liver regeneration in rats subjected to a partial hepatectomy" (THESIS/DISSERTATION)
 Distinção
2000/06/29
Concluded
 B.S. in Medical Biology (Medical laboratory technologist) (Bachelor)
Haute Ecole Leonard de Vinci Institut Paul Lambin, Belgium
"Evaluation of mutations in the hMSH2 gene in the hereditary non-polyposis colorectal cancer (HNPCC)" (THESIS/DISSERTATION)
 Satisfaz
Affiliation

Science

Category
Host institution 		Employer
2013/03/01 - Current Postdoc (Research) Laboratório Associado ICVS 3B's, Portugal
2010/01/01 - 2011/12/31 Postdoc (Research) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal

Other Careers

Category
Host institution 		Employer
2012/05/23 - 2012/10/01 Técnico Superior (Técnico Superior) Laboratoires Macors, France
Projects

Grant

Designation Funders
2018/05/01 - 2019/01/31 Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus: a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet/Cell Niche
info:eu-repo/grantAgreement/EC/H2020/646075/EU
Post-doc Fellow
Laboratório Associado ICVS 3B's, Portugal
 European Commission
Ongoing
2016/05/01 - 2018/04/28 An integrated multidisciplinary tissue engineering approach combining novel high-throughput screening and advanced methodologies to create complex biomaterials-stem cells constructs
info:eu-repo/grantAgreement/EC/FP7/321266/EU
Post-doc Fellow
Laboratório Associado ICVS 3B's, Portugal
 European Commission
Concluded
2015/06/01 - 2015/09/30 Unlocking the research potential of 3Bs Group, University of Minho, in Nanomedicine field to strengthen its competitive position at the European level
info:eu-repo/grantAgreement/EC/FP7/316331/EU
Post-doc Fellow
Laboratório Associado ICVS 3B's, Portugal
 European Commission
Concluded
2015/01/06 - 2015/05/31 Integration of cutting-edge health science research and ground-breaking technologies for the development of new clinically useful therapies, tissue regeneration strategies, advanced prophylactic measures and diagnosis methods
N-01-01-01-24-01-07
Post-doc Fellow
Laboratório Associado ICVS 3B's, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
2013/01/03 - 2014/12/31 Development of new products and regenerative therapies for the treatment of articular pathologies
QREN-13/SI/2011-23189
Post-doc Fellow
Laboratório Associado ICVS 3B's, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
2009/11 - 2011/12 HumanYeast
SFRH/BPD/62856/2009
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2019/02/01 - 2025/01/31 Não disponível
DL 57/2016/CP1377/CT0086
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/02/01 - 2024/01/31 Microcápsulas Poliméricas Obtidas por Automontagem Camada-a-Camada em Suportes Inorgânicos Com Capacidade de Encapsulamento Multimodal de Drogas Para o Tratamento do Cancro da Mama
PTDC/CTM-REF/0022/2020
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2022/06/30 Regeneração nervosa nano-acelerada com capacitação optogenética para o fortalecemento da funcionalidade neuromuscular
PTDC/NAN-MAT/29936/2017
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2021/12/31 Exopolissacarídeo de Kefiran: Biopolímero promissor para uso em medicina regenerativa e engenharia de tecidos
PTDC/BTM-MAT/29760/2017
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/02/01 - 2021/07/31 Biofabricação de estruturas 3D funcionalizadas para regeneração meniscal personalizada
PTDC/BBB-ECT/2690/2014
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/09/01 - 2021/02/28 Estratégias de administração intratecal de células progenitoras encapsuladas em hidrogéis guiada por Imagiologia de Ressonância Magnética para o tratamento da esclerose lateral amiotrófica
ENMed/0008/2015
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2011/12/31 HUMANYEAST
SFRH/BPD/62856/2009
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. da Silva Morais, Alain; Oliveira, Joaquim Miguel; Reis, Rui L.. "Biomaterials and Microfluidics for Liver Models". In Biomaterials- and microfluidics-based tissue engineered 3D in vitro models, edited by Oliveira, Joaquim Miguel; Reis, Rui L.. Portugal: Springer, Berlin, Heidelberg, 2020.
    Accepted
  2. da Silva Morais, Alain; Oliveira, J. Miguel; Reis, Rui L.. "Small Animal Models". In Osteochondral tissue engineering: Challenges, current strategies, and technological advances, 423-439. Portugal: Springer International Publishing, 2018.
    Published • 10.1007/978-3-319-76735-2_19
  3. Vilela, Carlos A.; da Silva Morais, Alain; Pina, Sandra Cristina Almeida; Oliveira, J. M.; Correlo, V. M.; Reis, R. L.; Espregueira-Mendes, João. "Clinical trials and management of osteochondral lesions". In Osteochondral Tissue Engineering, 391-413. Portugal: Springer, 2018.
    Published • 10.1007/978-3-319-76711-6_18
  4. da Silva Morais, Alain; Oliveira, J. M.; Reis, R. L.. "Cartilage tissue engineering and regenerative strategies". In Regenerative Strategies for the Treatment of Knee Joint Disabilities, 73-96. Portugal: Springer International Publishing, 2017.
    Published • 10.1007/978-3-319-44785-8_5
  5. da Silva Morais, Alain; Maia, F. Raquel; Reis, Rui L.; Oliveira, Joaquim M.. "Cell Culture Methods". In Bio-orthopaedics, 619-635. Portugal: Springer Berlin Heidelberg, 2017.
    Published • 10.1007/978-3-662-54181-4_49
Conference paper
  1. Ribeiro, V. P.; da Silva Morais, Alain; Maia, F. Raquel; Oliveira, A. L.; Oliveira, J. M.; Reis, R. L.. "Combinatory approach for developing silk fibroin-based scaffolds seeded with human adipose-derived stem cells for a cartilage tissue engineering applications". Paper presented in TERMIS-EU, Davos, 2017.
    Published
  2. Vieira, Sílvia; da Silva Morais, Alain; Reis, R. L.; Oliveira, J. M.. "Gellan gum: a multifunctional tool to modulate cell microenvironment". 2017.
    Vieira S., Morais A., Reis R. L., Oliveira J. M. Gellan Gum: a Multifunctional Tool to Modulate Cell Microenvironment, Tissue Engineering Part A, Vol. 23, Issue S1, doi:10.1089/ten.tea.2017.29003.abstracts, 2017
  3. da Silva Morais, Alain; Correia, Cristina; Vilela, Carlos A.; Gertrudes, Ana; Learmonth, David Alexander; Oliveira, Joaquim M.; Sousa, Rui A.; Reis, R. L.. "Development & performance assessment of a new ATMP for cartilage tissue engineering". 2016.
    10.3389/conf.FBIOE.2016.01.02807
  4. Ribeiro, Viviana Pinto; Silva-Correia, Joana; da Silva Morais, Alain; Correlo, V. M.; Marques, A. P.; Ribeiro, A. S.; Silva, Carla; et al. "Finely tuned fiber-based porous structures for bone tissue engineering applications". 2016.
    10.3389/conf.FBIOE.2016.01.02658
  5. da Silva Morais, Alain; Correia, Cristina; Vilela, Carlos A.; Gertrudes, Ana C.; Santos, Tírcia C.; Oliveira, Joaquim M.; Espregueira-Mendes, João; Sousa, Rui A.; Reis, Rui L.. "A one-step combined therapy for cartilage repair: Development & performance assessment.". Genova, 2014.
    Published • 10.1002/term.1931
Conference poster
  1. Ribeiro, Viviana P.; Cengiz, I. F.; Canadas, Raphael F.; Costa, João Bebiano; Vieira, Sílvia; da Silva Morais, Alain; Vilela, Carlos A.; et al. "Hierarchical bilayered silk fibroin scaffolds containing ZnSr-ß-TCP particles for osteochondral tissue regeneration". Paper presented in Chem2Nature, 2018.
  2. da Silva Morais, Alain; Reis, Rui L.; Oliveira, Joaquim M.. "Bioprinting of a perfusable liver implantable device for hepatic functions recovery and drugs screening". Paper presented in TERMSTEM/ForeCast, 2017.
  3. Vieira, Sílvia; da Silva Morais, Alain; Silva-Correia, Joana; Reis, Rui L.; Oliveira, Joaquim M.. "Gellan gum-based capsules for cell therapies". Paper presented in TERMSTEM/ FoReCaST, 2017.
  4. Costa, João Bebiano; Silva-Correia, Joana; Ribeiro, Viviana P.; da Silva Morais, Alain; Oliveira, Joaquim M.; Reis, Rui L.. "3D printing of patient-specific silk fibroin/elastina implants for intervertebral disc regeneration". Paper presented in TERMSTEM/FoReCaST, 2017.
  5. Ribeiro, Viviana P.; da Silva Morais, Alain; Maia, F. Raquel; Oliveira, Ana L.; Oliveira, Joaquim M.; Reis, Rui L.. "Combinatory approach for developing silk fibroin-based scaffolds to support human adipose-derived stem cells chondrogenic differentiation". Paper presented in European Society for Biomaterials (ESB), 2017.
  6. da Silva Morais, Alain; Reis, Rui L.; Oliveira, Joaquim M.. "Tissue engineering approaches for liver regeneration". Paper presented in Chem2Nature second school, 2017.
  7. Ribeiro, Viviana P.; da Silva Morais, Alain; Maia, F. Raquel; Oliveira, Ana L.; Oliveira, Joaquim M.; Reis, Rui L.. "Enzymatically cross-linked silk fibroin scaffolds support human adipose-derived stem cells chondrogenesis for cartilage tissue engineering applications". Paper presented in Society for Biomaterials (SFB), 2017.
  8. Ribeiro, Viviana P.; da Silva Morais, Alain; Oliveira, Ana L.; Oliveira, Joaquim M.; Reis, Rui L.. "Enzymatically cross-linked silk fibroin scaffolds support human adipose-derived stem cells chondrogenesis for cartilage tissue engineering applications". Paper presented in Term Stem, 2016.
  9. Costa, João B.; Ribeiro, Viviana P.; Cengiz, I. F.; da Silva Morais, Alain; Silva-Correia, Joana; Oliveira, J. Miguel; Reis, Rui L.. "Advanced tissue engineering strategies for biofabrication of complex tissues". Paper presented in Term Stem, 2016.
  10. Vieira, Sílvia; Vial, Stephanie; da Silva Morais, Alain; Carvalho, Mariana Rodrigues; Reis, Rui L.; Oliveira, Joaquim M.; Reis, R. L.; Oliveira, J. M.. "Gellan-gum coated gold nanorods: A new tool for biomedical applications.". Paper presented in 10TH WORLD BIOMATERIALS CONGRESS (WBC), 2016.
    10.3389/conf.FBIOE.2016.01.01358
  11. Ribeiro, Viviana P.; da Silva Morais, Alain; Correlo, Vitor M.; Marques, Alexandra P.; Ribeiro, Ana; Silva, Carla; Durães, Nelson; et al. "Textile-based Silk Scaffolds for Bone Tissue Engineering Applications.". Paper presented in 27th European Conference on Biomaterials ESB2015, 2015.
  12. Correia, Cristina; Frias, Ana M.; Moreira, Elsa S.; Gertrudes, Ana C.; Costa, Dulce S.; Learmonth, David A.; Marques, Marisa; et al. "Steering progenitor cells from human adipose tissue along the clinical highway: Clinical grade manufacturing and ATMP development". Paper presented in ISSCR 2015, 2015.
  13. Canadas, Raphael F.; Pereira, Diana R.; Silva-Correia, Joana; Viegas, C.; da Silva Morais, Alain; Sousa, Rui A.; Marques, Alexandra P.; Reis, Rui L.; Oliveira, Joaquim M.. "In vivo performance of gellan gum-based structures: A comparison study between hydrogels and spongy-like scaffolds for osteochondral tissue regeneration". Paper presented in 5th ICVS/3B's Associated laboratory meeting, 2015.
  14. Correia, Cristina; da Silva Morais, Alain; Vilela, Carlos A.; Gertrudes, Ana C.; Santos, Tírcia C.; Oliveira, Joaquim M.; Espregueira-Mendes, João; Sousa, Rui A.; Reis, Rui L.. "A one-step, off-the-shelf, minimally-invasive and non-angiogenic combined therapy that outperformed microfracture on cartilage repair". Paper presented in 12th World Congress of the International Cartilage Repair Society (ICRS), 2015.
  15. Correia, Cristina; da Silva Morais, Alain; Vilela, Carlos A.; Gertrudes, Ana C.; Santos, Tírcia C.; Oliveira, Joaquim M.; Espregueira-Mendes, João; Sousa, Rui A.; Reis, Rui L.. "Stem Cells from the adipose tissue as allogenic player in cartilage repair: in vivo performance". Paper presented in World Stem Cell Summit, 2014.
  16. Correia, Cristina; da Silva Morais, Alain; Vilela, Carlos A.; Radhouani, Hajer; Gonçalves, Cristiana; Gertrudes, Ana C.; Santos, Tírcia C.; et al. "In vitro and in vivo performance of an alternative therapy for osteoarthritis". Paper presented in TERMIS, 2014.
  17. da Silva Morais, Alain; Ferreira, Célia; Teixeira, Manuel; Lucas, Cândida. "The yeast Saccharomyces cerevisiae is sensitive to colorectal cancer routine treatment anti-EGFR antibody Cetuximab®". Paper presented in Microbiotec11, 2011.
  18. da Silva Morais, Alain; Abarca-Quinones, J.; Hue, L.; Viollet, B.; Horsmans, Y.; Leclercq, I.A.. "Impact of AMP-Activated Protein Kinase (AMPK) on the control of hepatic stellate cells (HSCs) activation in vitro". Paper presented in 43th Annual Meeting of the European Association for the Study of the Liver (EASL), 2008.
  19. da Silva Morais, Alain; Abarca-Quinones, J.; Stärkel, P.; Horsmans, Y.; Leclercq, I.A.. "PPARgamma ligand Pioglitazone does not prevent hepatic fibrosis in mice". Paper presented in 41th Annual Meeting of the European Association for the Study of the Liver (EASL), 2006.
  20. da Silva Morais, Alain; da Saeger, C.; Saliez, A.; Leclercq, I.A.; Horsmans, Y.; Stärkel, P.. "Inhibition of membrane anchorage of the Ras oncoprotein reduces hepatocyte proliferation in rats after partial hepatectomy". Paper presented in 40th Annual Meeting of the European Association for the Study of the Liver (EASL), 2005.
Encyclopedia entry
  1. Vieira, Sílvia; da Silva Morais, Alain; Silva-Correia, Joana; Oliveira, J. Miguel; Reis, Rui L.. "Natural-Based Hydrogels: From Processing to Applications". In Encyclopedia of Polymer Science and Technology. John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/0471440264.pst652.
    Published • 10.1002/0471440264.pst652
Journal article
  1. Sandra Amaral; Tamara Lozano-Fernández; Juan Sabin; Amanda Gallego; Alain da Silva Morais; Rui L. Reis; África González-Fernández; Iva Pashkuleva; Ramon Novoa-Carballal. "End-on PEGylation of heparin: Effect on anticoagulant activity and complexation with protamine". International Journal of Biological Macromolecules 249 (2023): 125957-125957. http://dx.doi.org/10.1016/j.ijbiomac.2023.125957.
    10.1016/j.ijbiomac.2023.125957
  2. Marta R. Casanova; Paulo Mota; Helena Vala; Carmen Nóbrega; Alain da Silva Morais; Catarina S. Silva; Alexandre A. Barros; et al. "Functional recovery of injured cavernous nerves achieved through endogenous nerve growth factor-containing bioactive fibrous membrane". Acta Biomaterialia (2023): https://doi.org/10.1016/j.actbio.2023.07.015.
    10.1016/j.actbio.2023.07.015
  3. omar alheib; Lucilia P da Silva; Katia A Mesquita; Alain da Silva Morais; R.P. Pirraco; Rui L Reis; Vitor Manuel Correlo. "Human adipose-derived mesenchymal stem cells laden in gellan gum spongy-like hydrogels for volumetric muscle loss treatment". Biomedical Materials (2023): http://dx.doi.org/10.1088/1748-605x/acf25b.
    10.1088/1748-605x/acf25b
  4. Helena R. Moreira; Daniel B. Rodrigues; Sara Freitas-Ribeiro; Lucília P. da Silva; Alain da S. Morais; Mariana Jarnalo; Ricardo Horta; et al. "Spongy-like hydrogels prevascularization with the adipose tissue vascular fraction delays cutaneous wound healing by sustaining inflammatory cell influx". Materials Today Bio 17 (2022): 100496-100496. http://dx.doi.org/10.1016/j.mtbio.2022.100496.
    10.1016/j.mtbio.2022.100496
  5. Helena R. Moreira; Daniel Barreira Rodrigues; Sara Freitas-Ribeiro; da Silva, L.P.; Alain da S. Morais; Mariana Jarnalo; Ricardo Horta; et al. "Integrin-specific hydrogels for growth factor-free vasculogenesis". npj Regenerative Medicine 7 1 (2022): http://dx.doi.org/10.1038/s41536-022-00253-4.
    10.1038/s41536-022-00253-4
  6. Omar Alheib; Lucília P. da Silva; Alain da Silva Morais; Katia A. Mesquita; Rogério P. Pirraco; Rui L. Reis; Vítor M. Correlo. "Injectable laminin-biofunctionalized gellan gum hydrogels loaded with myoblasts for skeletal muscle regeneration". Acta Biomaterialia 143 (2022): 282-294. https://doi.org/10.1016/j.actbio.2022.03.008.
    10.1016/j.actbio.2022.03.008
  7. "Methacrylated Gellan Gum/Poly-l-lysine Polyelectrolyte Complex Beads for Cell-Based Therapies". ACS Biomaterials Science & Engineering 7 10 (2021): 4898-4913. http://dx.doi.org/10.1021/acsbiomaterials.1c00486.
    10.1021/acsbiomaterials.1c00486
  8. Lara Pierantoni; Viviana P. Ribeiro; Lígia Costa; Sandra Pina; Alain da Silva Morais; Joana Silva-Correia; Subhas C. Kundu; et al. "Horseradish Peroxidase-Crosslinked Calcium-Containing Silk Fibroin Hydrogels as Artificial Matrices for Bone Cancer Research". Macromolecular Bioscience (2021): https://doi.org/10.1002/mabi.202000425.
    10.1002/mabi.202000425
  9. Oliveira, Isabel Matos; Gonçalves, Cristiana; Oliveira, Eduarda Pinheiro; Simón-Vázquez, Rosana; da Silva Morais, Alain; González-Fernández, África; Reis, Rui Luis; Oliveira, Joaquim Miguel. "PAMAM dendrimers functionalised with an anti-TNF a antibody and chondroitin sulphate for treatment of rheumatoid arthritis". Materials Science and Engineering: C 121 (2021): 111845. http://dx.doi.org/10.1016/j.msec.2020.111845.
    10.1016/j.msec.2020.111845
  10. Cengiz, Ibrahim Fatih; Maia, Fatima Raquel; da Silva Morais, Alain; Silva-Correia, Joana; Pereira, Helder; Canadas, Raphael F; Espregueira-Mendes, João; et al. "Entrapped in cage (EiC) scaffolds of 3D-printed polycaprolactone and porous silk fibroin for meniscus tissue engineering". Biofabrication (2020): http://dx.doi.org/10.1088/1758-5090/ab779f.
    Published • 10.1088/1758-5090/ab779f
  11. da Silva Morais, Alain; Vieira, Sílvia; Zhao, Xinlian; Mao, Zhengwei; Gao, Changyou; Oliveira, Joaquim M.; Reis, Rui L.. "Advanced Biomaterials and Processing Methods for Liver Regeneration: State-of-the-Art and Future Trends". Advanced Healthcare Materials (2020): 1901435. http://dx.doi.org/10.1002/adhm.201901435.
    Published • 10.1002/adhm.201901435
  12. "Indirect printing of hierarchical patient-specific scaffolds for meniscus tissue engineering". Bio-Design and Manufacturing 2 4 (2019): 225-241. http://dx.doi.org/10.1007/s42242-019-00050-x.
    10.1007/s42242-019-00050-x
  13. Vieira, Sílvia; da Silva Morais, Alain; Garet, Elina; Silva-Correia, Joana; Reis, Rui L.; González-Fernández, África; Miguel Oliveira, J.. "Self-mineralizing Ca-enriched methacrylated gellan gum beads for bone tissue engineering". Acta Biomaterialia 93 (2019): 74-85. http://dx.doi.org/10.1016/j.actbio.2019.01.053.
    Published • 10.1016/j.actbio.2019.01.053
  14. Canadas, Raphael F.; da Silva Morais, Alain; Patrício, P.; Gasperini, L.; Costa, J.; Araújo, N.; Reis, Rui L.; Marques, Alexandra P.; Oliveira, Joaquim M.. "Thermally-induced gradients in gels for programmable spatial distribution of bioactive factors". Journal of the American Chemical Society (2019):
    Submitted
  15. "Injectable gellan-gum/hydroxyapatite-based bilayered hydrogel composites for osteochondral tissue regeneration". Applied Materials Today 12 (2018): 309-321. http://dx.doi.org/10.1016/j.apmt.2018.06.005.
    10.1016/j.apmt.2018.06.005
  16. Carvalho, Cristiana R.; Costa, João B.; da Silva Morais, Alain; López-Cebral, Rita; Silva-Correia, Joana; Reis, Rui L.; Oliveira, J. Miguel. "Tunable Enzymatically Cross-Linked Silk Fibroin Tubular Conduits for Guided Tissue Regeneration". Advanced Healthcare Materials 7 17 (2018): 1800186. http://dx.doi.org/10.1002/adhm.201800186.
    Published • 10.1002/adhm.201800186
  17. Ribeiro, Viviana P.; da Silva Morais, Alain; Maia, F. Raquel; Canadas, Raphael F.; Costa, João B.; Oliveira, Ana L.; Oliveira, Joaquim M.; Reis, Rui L.. "Combinatory approach for developing silk fibroin scaffolds for cartilage regeneration". Acta Biomaterialia 72 (2018): 167-181. http://dx.doi.org/10.1016/j.actbio.2018.03.047.
    Published • 10.1016/j.actbio.2018.03.047
  18. Vilela, Carlos A.; Correia, Cristina; da Silva Morais, Alain; Santos, Tírcia C.; Gertrudes, Ana C.; Moreira, Elsa S.; Frias, Ana M.; et al. "In vitro and in vivo performance of methacrylated gellan gum hydrogel formulations for cartilage repair". Journal of Biomedical Materials Research Part A 106 7 (2018): 1987-1996. http://dx.doi.org/10.1002/jbm.a.36406.
    10.1002/jbm.a.36406
  19. Costa, João Bebiano; Silva-Correia, Joana; Ribeiro, Viviana Pinto; da Silva Morais, Alain; Oliveira, Joaquim Miguel; Reis, Rui Luís. "Engineering patient-specific bioprinted constructs for treatment of degenerated intervertebral disc". Materials Today Communications (2018): http://dx.doi.org/10.1016/j.mtcomm.2018.01.011.
    Published • 10.1016/j.mtcomm.2018.01.011
  20. Ribeiro, Viviana P.; Silva-Correia, Joana; Nascimento, Ana I.; da Silva Morais, Alain; Marques, Alexandra P.; Ribeiro, Ana S.; Silva, Carla J.; et al. "Silk-based anisotropical 3D biotextiles for bone regeneration". Biomaterials 123 Supplement (2017): 92-106. http://dx.doi.org/10.1016/j.biomaterials.2017.01.027.
    Published • 10.1016/j.biomaterials.2017.01.027
  21. Ondrésik, Marta; Azevedo Maia, Fatima R.; da Silva Morais, Alain; Gertrudes, Ana C.; Dias Bacelar, Ana H.; Correia, Cristina; Gonçalves, Cristiana; et al. "Management of knee osteoarthritis. Current status and future trends". Biotechnology and Bioengineering 114 4 (2016): 717-739. http://dx.doi.org/10.1002/bit.26182.
    10.1002/bit.26182
  22. Yan, Le-Ping; Silva-Correia, Joana; Ribeiro, Viviana P.; Miranda-Gonçalves, Vera; Correia, Cristina; da Silva Morais, Alain; Sousa, Rui A.; et al. "Tumor Growth Suppression Induced by Biomimetic Silk Fibroin Hydrogels". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep31037.
    Published • 10.1038/srep31037
  23. Correia, S. I.; Silva-Correia, J.; Pereira, H.; Canadas, R. F.; da Silva Morais, Alain; Frias, A. M.; Sousa, R. A.; et al. "Posterior talar process as a suitable cell source for treatment of cartilage and osteochondral defects of the talus". Journal of Tissue Engineering and Regenerative Medicine 11 7 (2015): 1949-1962. http://dx.doi.org/10.1002/term.2092.
    Published • 10.1002/term.2092
  24. da Silva Morais, Alain; Abarca-Quinones, Jorge; Guigas, Bruno; Viollet, Benoit; Stärkel, Peter; Horsmans, Yves; Leclercq, Isabelle A.; et al. "Development of hepatic fibrosis occurs normally in AMPK-deficient mice". Clinical Science 118 6 (2010): 411-420. http://dx.doi.org/10.1042/cs20090293.
    Published • 10.1042/cs20090293
  25. da Silva Morais, Alain; Lebrun, Valérie; Abarca-Quinones, Jorge; Brichard, Sonia; Hue, Louis; Guigas, Bruno; Viollet, Benoit; Leclercq, Isabelle A.. "Prevention of steatohepatitis by pioglitazone: Implication of adiponectin-dependent inhibition of SREBP-1c and inflammation". Journal of Hepatology 50 3 (2009): 489-500. http://dx.doi.org/10.1016/j.jhep.2008.10.027.
    Published • 10.1016/j.jhep.2008.10.027
  26. da Silva Morais, Alain; Saliez, Alain; Leclercq, Isabelle; Horsmans, Yves; Stärkel, Peter; Da Silva Morais, A.; Saliez, A.; et al. "Inhibition of the Ras oncoprotein reduces proliferation of hepatocytesin vitroandin vivoin rats". Clinical Science 114 1 (2008): 73-83. http://dx.doi.org/10.1042/cs20070152.
    Published • 10.1042/cs20070152
  27. Leclercq, Isabelle A.; Da Silva Morais, Alain; Schroyen, Ben; Van Hul, Noémi; Geerts, Albert. "Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms and consequences". Journal of Hepatology 47 1 (2007): 142-156. http://dx.doi.org/10.1016/j.jhep.2007.04.002.
    10.1016/j.jhep.2007.04.002
  28. da Silva Morais, Alain; Abarca-Quinones J; Horsmans Y; Stärkel P; Leclercq IA. "Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in mice.". Int J Mol Med. (2007): http://europepmc.org/abstract/med/17143554.
    10.3892/ijmm.19.1.105

Intellectual property

Patent
  1. Sousa, Rui Pedro Romero Amandi; Gertrudes, Ana C.; Correia, Cristina; da Silva Morais, Alain; Gonçalves, Cristiana; Radhouani, Hajer; Vilela, Carlos A.; et al. 2017. "Viscosupplement composition comprising ulvan for treating arthritis". Portugal.
    Pending
  2. Sousa, Rui Pedro Romero Amandi; Correia, Cristina; Vilela, Carlos A.; da Silva Morais, Alain; Gertrudes, Ana C.; Santos, Tírcia C.; Oliveira, Joaquim M.; Espregueira-Mendes, João; Reis, Rui L.. 2015. "PRODUCTS FOR REPAIRING CARTILAGE LESIONS, METHOD OF PREPARATION AND USES THEREOF". Portugal.
    Granted/Issued
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/04/12 Silk Fibroin/Elastin Bioinks for 3D Printing of Implants Respecting the Patient Intervertebral Disc Anatomy Society For Biomaterials Annual Meeting & Exposition
Society For Biomaterials (Atlanta, United States)
2017/06/26 Combinatory approach for developing silk fibroin-based scaffolds seeded with human adipose-derived stem cells for a cartilage tissue engineering applications TERMIS EU
TERMIS EU (Davos, Switzerland)
2017/06/06 Gellan gum-based capsules for cell therapies Chem2Nature second school
Chem2Nature (Porto, Portugal)
2016/10/28 Enzymatically cross-linked silk fibroin scaffolds support human adipose-derived stem cells chondrogenesis for cartilage tissue engineering applications. TERMSTEM
TERMSTEM (Guimarães, Portugal)
2016/05/22 Finely tuned fiber-based porous structures for bone tissue engineering applications. 10TH WORLD BIOMATERIALS CONGRESS (WBC)
WORLD BIOMATERIALS CONGRESS (Montreal, Canada)
2016/05/18 Development & Performance Assessment of a New ATMP for Cartilage Tissue Engineering. 10TH WORLD BIOMATERIALS CONGRESS
WORLD BIOMATERIALS CONGRESS (Montreal)
2015/06/30 Nanoparticle-induced bioprinted liver for drug screening and tissue regeneration. 2ND POLARIS WORKSHOP CONFERENCE
POLARIS (Guimarães, Portugal)
2015/05/14 Complex 3D Architectures Based on Knitting Technologies for Bone Tissue Engineering Applications. MEDTEX2015
MEDTEX2015 (Lodz, Poland)
2014/10/23 Cartilage repair by a non-invansive one-step combined therapy. TERMSTEM
TERMSTEM (Porto, Portugal)
2014/06/10 A one-step combined therapy for cartilage repair: Development & performance assessment. TERMIS
TERMIS (Genova, Italy)
2008/04/25 Adiponectin-dependent activation of AMPK, but not of PPARa, is implicated in the preventive effect of pioglitazone on the steatohepatitis. 43th Annual Meeting of the European Association for the Study of the Liver (EASL)
European Association for the Study of the Liver (EASL) (Milan, Italy)
2008/02/22 Adiponectin-dependent activation of AMPK, but not of PPARa, is implicated in the preventive effect of pioglitazone on the steatohepatitis. 20th Belgian Week of Gastroenterology
Belgian Association for the Study of the Liver (Antwerp, Belgium)
2008/02/21 Impact of AMP-Activated Protein Kinase (AMPK) on the control of hepatic stellate cells (HSCs) activation in vitro 20th Belgian Week of Gastroenterology
Belgian Association for the Study of the Liver (Antwerp, Belgium)
2006/02/09 PPARg ligand Pioglitazone does not prevent hepatic fibrosis in mice 18th Belgian Week of Gastroenterology
Belgian Association for the Study of the Liver (Ostende, Belgium)
2005/02/24 Inhibition of membrane anchorage of the Ras oncoprotein reduces hepatocyte proliferation in rats after partial hepatectomy 17th Belgian Week of Gastroenterology
Belgian Association for the Study of the Liver (Spa)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2005/03/23 - 2006/02/02 Interuniversity Gastroenterology Exchange program
Seminar
 Interuniversity Gastroenterology Exchange program / Solvay Pharma
Université catholique de Louvain Bibliothèque des sciences de la santé, Belgium
2006/01/27 - 2006/01/29 EASL School of Hepatology
Workshop
 EASL School of Hepatology
European Association for the Study of the Liver, Switzerland
2005/04/22 - 2005/04/22 The stellate cell-myofibroblast transition in pathological organ remodelling
Workshop
 The stellate cell-myofibroblast transition in pathological organ remodelling
Vrije Universiteit Brussel, Belgium
Distinctions

Award

2008 Young investigator bursary European Association for the Study of the Liver (EASL)
European Association for the Study of the Liver, Switzerland
2006 Young investigator bursary European Association for the Study of the Liver (EASL)
European Association for the Study of the Liver, Switzerland
2005 Young investigator bursary European Association for the Study of the Liver (EASL)
European Association for the Study of the Liver, Switzerland