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João Paulo Soeiro Terra Teodoro. Concluiu o(a) Doutoramento em Biociências em 2012/10/19 pelo(a) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Doutoramento em Doutoramento em Biociências em 2012 pelo(a) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Mestrado em Mestrado em Biologia Celular em 2007 pelo(a) Universidade de Coimbra Faculdade de Ciencias e Tecnologia e Licenciatura em Biologia em 2005 pelo(a) Universidade de Coimbra Faculdade de Ciencias e Tecnologia. É Investigador Auxiliar (carreira) no(a) CNC.IBILI e Lecturer of several classes (both theoretical and practical) part of the "Bioenergetics" class of the Master course on Cellular and Molecular Biology. no(a) Universidade de Coimbra. Publicou 37 artigos em revistas especializadas. Possui 1 capítulo(s) de livros e 4 livro(s). Coorientou 1 dissertação(ões) de mestrado. Recebeu 1 prémio(s) e/ou homenagens. Participa e/ou participou como Investigador em 6 projeto(s). No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Berberine; Mitochondrial function; Liver bioenergetics; Obesity; SirT3; Biologia molecular; Obesidade; Ácidos gordos; CDCA; TG/ (GL+FFA) cycle; 3T3-L1 adipocytes; UCP-1; Mitochondria; .
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Identification

Personal identification

Full name
João Paulo Soeiro Terra Teodoro

Citation names

  • Soeiro Teodoro, João

Author identifiers

Ciência ID
A516-DE27-6619
ORCID iD
0000-0002-1244-275X
Researcher Id
F-5432-2011
Scopus Author Id
24777294200

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Beginner (A1) Beginner (A1) Intermediate (B1)
Spanish; Castilian Advanced (C1) Intermediate (B1) Beginner (A1) Advanced (C1)
Education
Degree Classification
2012/10/19
Concluded
 Biociências (Doutoramento)
Major in Especialidade: Biologia Celular e Molecular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Physiologic pathways and molecular mechanisms regulating energy homeostasis in diabetes" (THESIS/DISSERTATION)
 Distinção e Louvor, por unanimidade
2007
Concluded
 Mestrado em Biologia Celular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Esteatose Hepática: Mecanismos mitocondriais com relevância para a função celular" (THESIS/DISSERTATION)
 Muito Bom
2005
Concluded
 Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 15 (quinze) valores na licenciatura em Biologia
Affiliation

Science

Category
Host institution 		Employer
2019/02/01 - Current Auxiliary Researcher (Research) CNC.IBILI, Portugal
Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Others

Category
Host institution 		Employer
2016/09/01 - Current Invited Assistant Professor (Part time, 15%). Universidade de Coimbra, Portugal
2013 - Current Peer reviewer of over100 verified revisions for over 30 journals - full reviewer profile at Publons.com, WebofScience ResearcherID: F-5432-2011 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/09/10 - Current Lecturer of several classes (both theoretical and practical) part of the "Bioenergetics" class of the Master course on Cellular and Molecular Biology. Universidade de Coimbra, Portugal
2014 - 2019 Investigador Pós-Doutoramento CNC.IBILI, Portugal
2013/05/13 - 2013/05/17 Lecturer at the "Cellular Mechanisms of Disease" advanced course, part of the doctoral program on Biology. Universidade de Aveiro, Portugal
2013/02/18 - 2013/02/22 Lecturer at "Interactions of Nutrients with Mitochondria and Gene Expression." advanced course, part of the doctoral programme in Experimental Biology and Biomedicine (BEB). Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/01/21 - 2013/01/25 Lecturer at the "Cell and Molecular Toxicology" advanced course, part of the master's course on Toxicology and Ecotoxicology. Universidade de Aveiro, Portugal
2012/02/06 - 2012/02/10 Lecturer at the "Molecular Biology and Genetics II" advanced course. Universidade de Aveiro, Portugal
2012/01/16 - 2012/01/20 Lecturer at the "Cellular Mechanisms of Disease" advanced course, part of the doctoral program on Biology. Universidade de Aveiro, Portugal
2010/08/20 - 2011/04/10 Invited foreign scientist. Akademie ved Ceske republiky, Czech Republic
2011/02/14 - 2011/02/18 Lecturer at "Mitochondrial dynamics and metabolic diseases." advanced course, part of the doctoral programme in Experimental Biology and Biomedicine (BEB). Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/06/20 - 2008/12/14 Invited foreign scientist. University of Minnesota Duluth School of Medicine, United States
Projects

Contract

Designation Funders
2016/03/31 - 2019/12/31 A interação entre cAMP e Sirtuínas como um mecanismo de controlo mitocondrial e metabólico
PTDC/BIM-MEC/6911/2014
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014/05/01 - 2019/01/31 DETOXIFICATION OF FUEL OVERSUPPLY IN WAT THROUGH METABOLIC FUTILE CYCLING INDUCED BY BILE ACIDS
SFRH/BPD/94036/2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2019 Comparison of the acute effects of furan and its main metabolites cis-2-butene-1,4-dial (CBD) in human and rat hepatocyte
CSD018001#IV0026
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Institute for Scientific Information on Coffee
Concluded
2016 - 2019 EXERCITANDO O FUTURO: Exercício Voluntário Durante Diabetes Gestacional com uma Estratégia para Melhorar a Função Mitocondrial na Descendência.
PTDC/DTP-DES/1082/2014
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Faculdade de Desporto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2014 Chronic effects of silver nanoparticles (AgNPs) on rat liver, kidney and heart mitochondrial function.
FA8655-13-1-3036
Researcher
European Office of Aerospace Research and Development (EOARD), United States
Concluded
2011 - 2012 ABILITY OF A MITOCHONDRIA IMPROVER, BERBERINE, TO ATTENUATE PARKINSON'S DISEASE.
RRIA 2011
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

European Office of Aerospace Research and Development (EOARD), United States
Michael J. Fox Foundation for Parkinson's Research
Concluded
2007/10/01 - 2011/09/30 PHYSIOLOGIC PATHWAYS AND MOLECULAR MECHANISMS REGULATING ENERGY HOMEOSTASIS IN DIABETES
SFRH/BD/38467/2007
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/09/01 - 2010/12/31 Alterações nas vias fisiológicas e mecanismos moleculares reguladores da homeostase energética na obesidade e síndrome metabólico: identificação de novas estratégias e alvos terapêuticos
PTDC/SAU-OSM/72443/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2010/03/31 Modulação das vias metabólicas envolvidas no stress oxidativo mitocondrial em condições de hiperglicémia: sua relevância na prevenção da diabetes.
PTDC/QUI/72826/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/01 - 2010/03 MODULAÇÃO DAS VIAS METABÓLICAS ENVOLVIDAS NO STRESS OXIDATIVO MITOCONDRIAL EM CONDIÇÕES DE HIPERGLICÉMIA: SUA RELEVÂNCIA NA PREVENÇÃO DA DIABETES.
PTDC / QUI / 72826 / 2006
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2008 - 2010 Long-term beneficial influence of early metabolic control: prevention of hyperglycemic memory through stimulation of bioenergetics
PTDC / QUI-BIQ / 103514 / 2008
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2007 - 2010 ALTERAÇÕES NAS VIAS FISIOLÓGICAS E MECANISMOS MOLECULARES REGULADORES DA HOMEOSTASE ENERGÉTICA NA OBESIDADE E SÍNDROME METABÓLICO: IDENTIFICAÇÃO DE NOVAS ESTRATÉGIAS E ALVOS TERAPÊUTICOS.
PTDC /SAU-OSM / 72443 / 2006
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2007/06 - 2008/07 IN VITRO ASSESSMENT OF SILVER NANOPARTICLES TOXICITY IN HEPATIC MITOCHONDRIAL FUNCTION.
FA8655-07-1-3047
Researcher
European Office of Aerospace Research and Development (EOARD), United States
Concluded
Outputs

Publications

Book
  1. Teodoro, J.S.; Palmeira, C.M.; Rolo, A.P.. Determination of oxidative phosphorylation complexes activities. 2015.
    10.1007/978-1-4939-1875-1_7
  2. Teodoro, J.S.; Palmeira, C.M.; Rolo, A.P.. Determination of oxidative phosphorylation complexes activities. 2014.
  3. Palmeira, C.M.; Duarte, F.V.; Teodoro, J.S.; Varela, A.T.; Rolo, A.P.. Biomarkers of mitochondrial dysfunction and toxicity. 2014.
    10.1016/B978-0-12-404630-6.00051-8
Book chapter
  1. Teodoro, João Soeiro; Rolo, Anabela Pinto; Palmeira, Carlos Manuel Marques. "Mitochondrial Bioenergetic Assays as a Standard Protocol for Toxicological and Metabolic Assessment". In Methods in Molecular Biology, 231-241. Springer US, 2021.
    10.1007/978-1-0716-1091-6_16
  2. Teodoro, João S.; Machado, Ivo F.; Castela, Ana C.; Rolo, Anabela P.; Palmeira, Carlos M.. "The Evaluation of Mitochondrial Membrane Potential Using Fluorescent Dyes or a Membrane-Permeable Cation (TPP+) Electrode in Isolated Mitochondria and Intact Cells". In Methods in Molecular Biology, 197-213. Springer US, 2020.
    10.1007/978-1-0716-0802-9_14
  3. Palmeira, Carlos M.; Teodoro, João S.; Silva, Rui; Rolo, Anabela P.. "Biomarkers of Mitochondrial Dysfunction and Toxicity". In Biomarkers in Toxicology, 981-996. Elsevier, 2019.
    10.1016/b978-0-12-814655-2.00055-4
  4. Teodoro, J.S.; Palmeira, C.M.; Rolo, A.P.; Teodoro, João Soeiro; Palmeira, Carlos Marques; Rolo, Anabela Pinto. "Mitochondrial membrane potential (¿¿) fluctuations associated with the metabolic states of mitochondria". In Methods in Molecular Biology, 109-119. Springer New York, 2018.
    10.1007/978-1-4939-7831-1_6
  5. Amorim, Joao Alves; Teodoro, Joao Soeiro; Palmeira, Carlos Marques; Rolo, Anabela Pinto. "Sirtuins and Bile Acids: Potential Anti-obesity Strategies Targeting Mitochondria". In Anti-Obesity Drug Discovery and Development: Volume 4, 57-97. BENTHAM SCIENCE PUBLISHERS, 2018.
    Published • 10.2174/9781681085586118040005
  6. Teodoro, João S.; Duarte, Filipe V.; Rolo, Anabela P.; Palmeira, Carlos M.; Teodoro, J.S.; Duarte, F.V.; Rolo, A.P.; Palmeira, C.M.. "Mitochondria as a Target for Safety and Toxicity Evaluation of Nutraceuticals". In Nutraceuticals, 387-400. Elsevier, 2016.
    Published • 10.1016/b978-0-12-802147-7.00028-0
  7. Palmeira, Carlos M.; Duarte, Filipe V.; Teodoro, João S.; Varela, Ana T.; Rolo, Anabela P.. "Biomarkers of mitochondrial dysfunction and toxicity". In Biomarkers in Toxicology, 847-861. Elsevier, 2014.
    Published • 10.1016/b978-0-12-404630-6.00051-8
  8. Teodoro, João S.; Palmeira, Carlos M.; Rolo, Anabela P.. "Determination of Oxidative Phosphorylation Complexes Activities". In Methods in Molecular Biology, 71-84. Springer New York, 2014.
    Published • 10.1007/978-1-4939-1875-1_7
Journal article
  1. João S. Teodoro; Rui T. Da Silva; Ivo F. Machado; Arnau Panisello-Roselló; Joan Roselló-Catafau; Anabela P. Rolo; Carlos M. Palmeira. "Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria". Cells (2022): https://doi.org/10.3390/cells11040688.
    10.3390/cells11040688
  2. Rui Teixeira da Silva; Ivo F. Machado; João S. Teodoro; Arnau Panisello-Roselló; Joan Roselló-Catafau; Anabela P. Rolo; Carlos M. Palmeira. "PEG35 as a Preconditioning Agent against Hypoxia/Reoxygenation Injury". International Journal of Molecular Sciences 23 3 (2022): 1156-1156. https://doi.org/10.3390/ijms23031156.
    10.3390/ijms23031156
  3. Sara Nunes; Sofia D. Viana; Inês Preguiça; André Alves; R. Fernandes; Teodoro, J.S.; Patrícia Matos; et al. "Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics". Nutrients (2021): https://www.mdpi.com/2072-6643/13/12/4192.
    10.3390/nu13124192
  4. João S. Teodoro; Ivo F. Machado; Ana C. Castela; João A. Amorim; Ivana Jarak; Rui A. Carvalho; Carlos M. Palmeira; Anabela P. Rolo. "Chenodeoxycholic Acid Has Non-Thermogenic, Mitodynamic Anti-Obesity Effects in an In Vitro CRISPR/Cas9 Model of Bile Acid Receptor TGR5 Knockdown". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222111738.
    10.3390/ijms222111738
  5. Ivo F. Machado; João S. Teodoro; Ana C. Castela; Carlos M. Palmeira; Anabela P. Rolo. "miR-378a-3p Participates in Metformin’s Mechanism of Action on C2C12 Cells under Hyperglycemia". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22020541.
    10.3390/ijms22020541
  6. Sara Nunes; Sofia D. Viana; Inês Preguiça; André Alves; Rosa Fernandes; João S. Teodoro; Artur Figueirinha; et al. "Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicits Transcriptomics Reprogramming in Healthy Wistar Rats". Pharmaceutics (2020): https://doi.org/10.3390/pharmaceutics12111094.
    10.3390/pharmaceutics12111094
  7. João S. Teodoro; Rui Silva; António Aguiar; Abílio J. F. N. Sobral; Anabela P. Rolo; Carlos M. Palmeira. "Exploration of the cellular effects of the high-dose, long-term exposure to coffee roasting product furan and its by-product cis-2-butene-1,4-dial on human and rat hepatocytes". Toxicology Mechanisms and Methods (2020): 1-10. https://doi.org/10.1080/15376516.2020.1780361.
    10.1080/15376516.2020.1780361
  8. João S. Teodoro; João A. Amorim; Ivo F. Machado; Ana C. Castela; Clemens Steegborn; David A. Sinclair; Anabela P. Rolo; Carlos M. Palmeira. "The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function". International Journal of Molecular Sciences 21 14 (2020): 4896-4896. https://doi.org/10.3390/ijms21144896.
    10.3390/ijms21144896
  9. Martins, R.M.; Teodoro, J.S.; Furtado, E.; Oliveira, R.C.; Tralhão, J.G.; Rolo, A.P.; Palmeira, C.M.. "Mild hypothermia during the reperfusion phase protects mitochondrial bioenergetics against ischemia-reperfusion injury in an animal model of ex-vivo liver transplantation—An experimental study". International Journal of Medical Sciences 16 9 (2019): 1304-1312. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072941379&partnerID=MN8TOARS.
    10.7150/ijms.34617
  10. Martins, R.M.; Teodoro, J.S.; Furtado, E.; Rolo, A.P.; Palmeira, C.M.; Tralhão, J.G.. "Evaluation of bioenergetic and mitochondrial function in liver transplantation". Clinical and Molecular Hepatology 25 2 (2019): 190-198. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068517981&partnerID=MN8TOARS.
    10.3350/cmh.2018.0087
  11. Palmeira, C.M.; Teodoro, J.S.; Amorim, J.A.; Steegborn, C.; Sinclair, D.A.; Rolo, A.P.. "Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins". Free Radical Biology and Medicine 141 (2019): 483-491. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069629808&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2019.07.017
  12. Teodoro, J.S.; Nunes, S.; Rolo, A.P.; Reis, F.; Palmeira, C.M.. "Therapeutic options targeting oxidative stress, mitochondrial dysfunction and inflammation to hinder the progression of vascular complications of diabetes". Frontiers in Physiology 10 JAN (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85065463466&partnerID=MN8TOARS.
    10.3389/fphys.2018.01857
  13. Machado, I.F.; Teodoro, J.S.; Palmeira, C.M.; Rolo, A.P.. "miR-378a: a new emerging microRNA in metabolism". Cellular and Molecular Life Sciences (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075434955&partnerID=MN8TOARS.
    10.1007/s00018-019-03375-z
  14. João Soeiro Teodoro; Ana Teresa Varela; Filipe Valente Duarte; Ana Patrícia Gomes; Carlos Marques Palmeira; Anabela Pinto Rolo. "Indirubin and NAD+ prevent mitochondrial ischaemia/reperfusion damage in fatty livers". European Journal of Clinical Investigation (2018): e12932-e12932. https://doi.org/10.1111/eci.12932.
    10.1111/eci.12932
  15. Martins, R.M.; Rolo, A.P.; Teodoro, J.S.; Furtado, E.; Oliveira, R.C.; Tralhão, J.G.; Palmeira, C.M.. "Addition of berberine to preservation solution in an animal model of ex vivo liver transplant preserves mitochondrial function and bioenergetics from the damage induced by ischemia/reperfusion". International Journal of Molecular Sciences 19 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85040938454&partnerID=MN8TOARS.
    10.3390/ijms19010284
  16. Martins, R.M.; Teodoro, J.S.; Furtado, E.; Rolo, A.P.; Palmeira, C.M.; Tralhão, J.G.. "Recent insights into mitochondrial targeting strategies in liver transplantation". International Journal of Medical Sciences 15 3 (2018): 248-256. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045188539&partnerID=MN8TOARS.
    10.7150/ijms.22891
  17. Alberto Rossetti; Gabriele Togliatto; Anabela P Rolo; João S Teodoro; Riccarda Granata; Ezio Ghigo; Amedeo Columbano; Carlos M Palmeira; Maria Felice Brizzi. "Unacylated ghrelin prevents mitochondrial dysfunction in a model of ischemia/reperfusion liver injury". Cell Death Discovery 3 1 (2017): https://doi.org/10.1038/cddiscovery.2017.77.
    10.1038/cddiscovery.2017.77
  18. Alexandrino, H.; Rolo, A.; Teodoro, J.S.; Donato, H.; Martins, R.; Serôdio, M.; Martins, M.; et al. "Bioenergetic adaptations of the human liver in the ALPPS procedure – how liver regeneration correlates with mitochondrial energy status". HPB 19 12 (2017): 1091-1103. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029605721&partnerID=MN8TOARS.
    10.1016/j.hpb.2017.08.005
  19. Milton-Laskibar, I.; Aguirre, L.; Fernández-Quintela, A.; Rolo, A.P.; Teodoro, J.S.; Palmeira, C.M.; Portillo, M.P.. "Lack of additive effects of resveratrol and energy restriction in the treatment of hepatic steatosis in rats". Nutrients 9 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85023760594&partnerID=MN8TOARS.
    10.3390/nu9070737
  20. Duarte, F.V.; Amorim, J.A.; Varela, A.T.; Teodoro, J.S.; Gomes, A.P.; Cunha, R.A.; Palmeira, C.M.; Rolo, A.P.. "Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver". Purinergic Signalling 13 2 (2017): 179-190. http://www.scopus.com/inward/record.url?eid=2-s2.0-84995486129&partnerID=MN8TOARS.
    10.1007/s11302-016-9548-x
  21. Teodoro, J.S.; Gomes, A.P.; Varela, A.T.; Duarte, F.V.; Rolo, A.P.; Palmeira, C.M.. "Hepatic and skeletal muscle mitochondrial toxicity of chitosan oligosaccharides of normal and diabetic rats". Toxicology Mechanisms and Methods 26 9 (2016): 650-657. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992521755&partnerID=MN8TOARS.
    10.1080/15376516.2016.1222643
  22. Teodoro, J.S.; Silva, R.; Varela, A.T.; Duarte, F.V.; Rolo, A.P.; Hussain, S.; Palmeira, C.M.. "Low-dose, subchronic exposure to silver nanoparticles causes mitochondrial alterations in Sprague-Dawley rats". Nanomedicine 11 11 (2016): 1359-1375. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971483351&partnerID=MN8TOARS.
    10.2217/nnm-2016-0049
  23. Alexandrino, H.; Varela, A.T.; Teodoro, J.S.; Martins, M.A.; Rolo, A.P.; Tralhão, J.G.; Palmeira, C.M.; Castro e Sousa, F.. "Mitochondrial bioenergetics and posthepatectomy liver dysfunction". European Journal of Clinical Investigation 46 7 (2016): 627-635. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976546519&partnerID=MN8TOARS.
    10.1111/eci.12639
  24. Teodoro, J.S.; Rolo, A.P.; Jarak, I.; Palmeira, C.M.; Carvalho, R.A.. "The bile acid chenodeoxycholic acid directly modulates metabolic pathways in white adipose tissue in vitro: insight into how bile acids decrease obesity". NMR in Biomedicine 29 10 (2016): 1391-1402. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988530079&partnerID=MN8TOARS.
    10.1002/nbm.3583
  25. Teodoro, J.S.; Varela, A.T.; Rolo, A.P.; Palmeira, C.M.. "High-fat and obesogenic diets: Current and future strategies to fight obesity and diabetes". Genes and Nutrition 9 4 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84904443541&partnerID=MN8TOARS.
    10.1007/s12263-014-0406-6
  26. Teodoro, J.S.; Zouhar, P.; Flachs, P.; Bardova, K.; Janovska, P.; Gomes, A.P.; Duarte, F.V.; et al. "Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice". International Journal of Obesity 38 8 (2014): 1027-1034. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905663740&partnerID=MN8TOARS.
    10.1038/ijo.2013.230
  27. Teodoro, J.S.; Gomes, A.P.; Varela, A.T.; Duarte, F.V.; Rolo, A.P.; Palmeira, C.M.. "Uncovering the beginning of diabetes: The cellular redox status and oxidative stress as starting players in hyperglycemic damage". Molecular and Cellular Biochemistry 376 1-2 (2013): 103-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874278002&partnerID=MN8TOARS.
    10.1007/s11010-012-1555-9
  28. Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M.. "The NAD ratio redox paradox: Why does too much reductive power cause oxidative stress?". Toxicology Mechanisms and Methods 23 5 (2013): 297-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878533789&partnerID=MN8TOARS.
    10.3109/15376516.2012.759305
  29. Teodoro, J.S.; Duarte, F.V.; Gomes, A.P.; Varela, A.T.; Peixoto, F.M.; Rolo, A.P.; Palmeira, C.M.; et al. "Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation". Mitochondrion 13 6 (2013): 637-646. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884937949&partnerID=MN8TOARS.
    10.1016/j.mito.2013.09.002
  30. Duarte, F.V.; Gomes, A.P.; Teodoro, J.S.; Varela, A.T.; Moreno, A.J.M.; Rolo, A.P.; Palmeira, C.M.. "Dibenzofuran-induced mitochondrial dysfunction: Interaction with ANT carrier". Toxicology in Vitro 27 8 (2013): 2160-2168. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885795993&partnerID=MN8TOARS.
    10.1016/j.tiv.2013.08.009
  31. Gomes, A.P.; Price, N.L.; Ling, A.J.Y.; Moslehi, J.J.; Montgomery, M.K.; Rajman, L.; White, J.P.; et al. "Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging". Cell 155 7 (2013): 1624-1638. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893442805&partnerID=MN8TOARS.
    10.1016/j.cell.2013.11.037
  32. Rolo, A.P.; Teodoro, J.S.; Palmeira, C.M.. "Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis". Free Radical Biology and Medicine 52 1 (2012): 59-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-84655169624&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2011.10.003
  33. Gomes, A.P.; Duarte, F.V.; Nunes, P.; Hubbard, B.P.; Teodoro, J.S.; Varela, A.T.; Jones, J.G.; et al. "Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis". Biochimica et Biophysica Acta - Molecular Basis of Disease 1822 2 (2012): 185-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-83255163155&partnerID=MN8TOARS.
    10.1016/j.bbadis.2011.10.008
  34. Duarte, F.V.; Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M.. "Exposure to dibenzofuran triggers autophagy in lung cells". Toxicology Letters 209 1 (2012): 35-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-84155176935&partnerID=MN8TOARS.
    10.1016/j.toxlet.2011.11.029
  35. Price, N.L.; Gomes, A.P.; Ling, A.J.Y.; Duarte, F.V.; Martin-Montalvo, A.; North, B.J.; Agarwal, B.; et al. "SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function". Cell Metabolism 15 5 (2012): 675-690. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860477354&partnerID=MN8TOARS.
    10.1016/j.cmet.2012.04.003
  36. Teodoro, J.S.; Simões, A.M.; Duarte, F.V.; Rolo, A.P.; Murdoch, R.C.; Hussain, S.M.; Palmeira, C.M.. "Assessment of the toxicity of silver nanoparticles in vitro: A mitochondrial perspective". Toxicology in Vitro 25 3 (2011): 664-670. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952039156&partnerID=MN8TOARS.
    10.1016/j.tiv.2011.01.004
  37. Duarte, F.V.; Simões, A.M.; Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M.. "Exposure to dibenzofuran affects lung mitochondrial function in vitro". Toxicology Mechanisms and Methods 21 8 (2011): 571-576. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053260979&partnerID=MN8TOARS.
    10.3109/15376516.2011.576714
  38. Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M.. "Hepatic FXR: Key regulator of whole-body energy metabolism". Trends in Endocrinology and Metabolism 22 11 (2011): 458-466. http://www.scopus.com/inward/record.url?eid=2-s2.0-82455164172&partnerID=MN8TOARS.
    10.1016/j.tem.2011.07.002
  39. Simes, A.M.; Duarte, F.V.; Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M.. "Exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and tetraethyl lead affects lung mitochondria bioenergetics". Toxicology Mechanisms and Methods 20 1 (2010): 1-6. http://www.scopus.com/inward/record.url?eid=2-s2.0-77149123078&partnerID=MN8TOARS.
    10.3109/15376510903527916
  40. Varela, A.T.; Simões, A.M.; Teodoro, J.S.; Duarte, F.V.; Gomes, A.P.; Palmeira, C.M.; Rolo, A.P.. "Indirubin-3'-oxime prevents hepatic I/R damage by inhibiting GSK-3ß and mitochondrial permeability transition". Mitochondrion 10 5 (2010): 456-463. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955424602&partnerID=MN8TOARS.
    10.1016/j.mito.2010.04.006
  41. Rolo, A.P.; Teodoro, J.S.; Peralta, C.; Rosello-Catafau, J.; Palmeira, C.M.. "Prevention of I/R injury in fatty livers by ischemic preconditioning is associated with increased mitochondrial tolerance: The key role of ATPsynthase and mitochondrial permeability transition". Transplant International 22 11 (2009): 1081-1090. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349668693&partnerID=MN8TOARS.
    10.1111/j.1432-2277.2009.00916.x
  42. Teodoro, J.S.; Rolo, A.P.; Duarte, F.V.; Simões, A.M.; Palmeira, C.M.. "Differential alterations in mitochondrial function induced by a choline-deficient diet: Understanding fatty liver disease progression". Mitochondrion 8 5-6 (2008): 367-376. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949089576&partnerID=MN8TOARS.
    10.1016/j.mito.2008.07.008
  43. Varela, A.T.; Gomes, A.P.; Simões, A.M.; Teodoro, J.S.; Duarte, F.V.; Rolo, A.P.; Palmeira, C.M.. "Indirubin-3'-oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction". Toxicology and Applied Pharmacology 233 2 (2008): 179-185. http://www.scopus.com/inward/record.url?eid=2-s2.0-56049123388&partnerID=MN8TOARS.
    10.1016/j.taap.2008.08.005
  44. Teodoro, J.; Rolo, A.P.; Oliveira, P.J.; Palmeira, C.M.. "Decreased ANT content in Zucker fatty rats: Relevance for altered hepatic mitochondrial bioenergetics in steatosis". FEBS Letters 580 8 (2006): 2153-2157. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645241135&partnerID=MN8TOARS.
    10.1016/j.febslet.2006.02.078
Thesis / Dissertation
  1. Silva, Maria Helena Almeida Braz da. "Modulation of TG/(GL+FFA) cycle as a therapeutic strategy to obesity". Master, 2014. http://hdl.handle.net/10773/13330.
  2. Teodoro, João Paulo Soeiro Terra. "Physiologic pathways and molecular mechanisms regulating energy homeostasis in diabetes". PhD, 2012. http://hdl.handle.net/10316/20945.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/05 Novel avenues of ischemia/reperfusion injury pervention: lessons from a soluble adenylyl cyclase inhibitor and a SirT3 activator. 53rd Annual Meeting of the European Society for Clinical Investigation AND 2019 MitoPorto – International Symposium of the Consortium for Mitochondrial Research
(Coimbra, Portugal)
2018/05 Exploring the role of the bile acid receptor TGR5 in bile acid mediated obesity control: Novel insights from a CRISPR/Cas9 adipocyte model. 52nd Annual Meeting of the European Society for Clinical Investigation
(Barcelona, Spain)
2017/05 The bile acid chenodeoxycholic acid directly modulates metabolic pathways in white adipose tissue in vitro: insight into how bile acids modulate obesity. 51st Annual Meeting of the European Society for Clinical Investigation
(Génova, Italy)
2015/12 The bile acid chenodeoxycholic acid directly modulates metabolic pathways in white adipose tissue in vitro: insight into how bile acids modulate obesity. 13th Annual Meeting of the Center for Neurosciences and Cell Biology of the University of Coimbra
(Coimbra, Portugal)
2014/05 Enhancement of brown fat thermogenesis using the bile acid chenodeoxycholic acid in mice. 48th Annual Scientific Meeting of the European Society for Clinical Investigation
(Utrecht, Netherlands)
2014/05 The effects of berberine on high fat-fed hepatic rat mitochondrial function: a possible role for Sirt3. 48th Annual Scientific Meeting of the European Society for Clinical Investigation
(Utrecht, Netherlands)
2010/05 Uncovering the beginning of diabetes: The reductive excess and oxidative damage as starting players in hyperglycemic damage. • International Courses on Toxicology of the Center for Neurosciences and Cell Biology of the University of Coimbra
(Coimbra, Portugal)
2009/05 Assessment of the toxicity of silver nanoparticles in vitro: a mitochondrial perspective. • International Courses on Toxicology of the Center for Neurosciences and Cell Biology of the University of Coimbra
(Coimbra, Portugal)
2007/12 Alterations in mitochondrial function induced by a choline-deficient diet: The role of mitochondria in disease progression. • 38th Annual Meeting of the Portuguese Society of Pharmacology, 24th Meeting of Clinical Pharmacology and 7th Meeting of Toxicology
(Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2014 - 2014 The effect of silver nanoparticles: a chronic in vivo study for the evaluation of the hepatic mitochondrial toxicity
Co-supervisor
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 - 2014 Modulation of TG/(GL+FFA) cycle as a therapeutic strategy to obesity
Co-supervisor
 Biologia Molecular e Celular (Master)
Universidade de Aveiro, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2017/12/13 The influence of the Fragile Mental Retardation-1 (FMR1) gene CGG repetitive region in the female reproductive function.
(Thesis) Main arguer
 Bárbara Luísa Cerqueira Rodrigues (Master)
Universidade de Aveiro, Portugal
2017/09/08 Alteração da sinalização dopaminérgica por desnervação do corpo carotídeo na modulação da função do tecido adiposo na síndrome metabólica.
(Thesis) Main arguer
 Ana Sofia Chasqueira dos Santos (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/12/11 Modulation of mitochondrial stress response by Sestrin 2
(Thesis) Main arguer
 MARIA CAROLINA COSTA E SANTOS BAPTISTA RODRIGUES (Master)
Universidade de Aveiro, Portugal
2014/09/09 Protection provided by phytoestrogens against cardiac lipotoxicity induced by palmitic acid
(Thesis) Main arguer
 Renata Lopes Familiar Couto (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Committee member

Activity description
Role 		Institution / Organization
2014 - Current Co-founding member of Elementar - Ciência Espectacular, Lda., a now-extinct science communication company. More details at: https://webelementar.wixsite.com/elementar
Other

Consulting

Activity description Institution / Organization
2019 - 2019 Assessment and appraisal of book proposal Elsevier BV, Netherlands

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2013 - Current Cell and Molecular Toxicology Toxicologia e Ecotoxicologia (Mestrado integrado) Universidade de Aveiro, Portugal
2013 - Current Interactions of Nutrients with Mitochondria and gene expression Programa doutoral em Biologia Experimental e Biomedicina (PDBEB) (Doutoramento) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 - Current Cellular Mechanisms of Disease Programa doutoral em Biologia (Doutoramento) Universidade de Aveiro, Portugal
2012 - Current Cellular Mechanisms of Disease Programa doutoral em Biologia (Doutoramento) Universidade de Aveiro, Portugal
2012 - Current Molecular Biology and Genetics II Programa doutoral em Biologia Universidade de Aveiro, Portugal
2011 - Current Mitochondrial dynamics and metabolic diseases Programa doutoral em Biologia Experimental e Biomedicina (PDBEB) (Doutoramento) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2007 - Current Toxicidade e Doença Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2019 Laboratórios de Biologia Molecular Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Mentoring / Tutoring

Topic Student name
2022/02/01 - 2022/02/28 Rotação Laboratorial inserida no Mestrado em Biologia Celular e Molecular da UC Ana Carolina Pinto
2020/02/01 - 2020/02/29 Methods in Molecular Biology and Bioenergetics Ana Teresa Maduro
Distinctions

Other distinction

2017 CEEC Assistant Researcher
Fundação para a Ciência e a Tecnologia, Portugal
2015 Best oral presentation at the XIII Annual Meeting of the CNC
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 Post-Doctoral Scholarship
Fundação para a Ciência e a Tecnologia, Portugal
2007 PhD Scolarship
Fundação para a Ciência e a Tecnologia, Portugal