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Helena Leal. Completed the Mestrado in Mestrado em Biologia Celular e Molecular in 2015 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia and Licenciatura in Licenciatura em Biologia in 2013 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia. Is Researcher in Universidade de Coimbra Centro de Neurociências e Biologia Celular. Has received 1 awards and/or honors.
Identification

Personal identification

Full name
Helena Leal

Citation names

  • Leal, Helena

Author identifiers

Ciência ID
A612-14FC-6ECE
ORCID iD
0000-0002-8657-9433

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Biology
  • Natural sciences - Biological Sciences - Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2016 - 2021
Ongoing
 Doutoramento em Ciências Farmaceuticas (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015
Concluded
 Mestrado em Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Impact of obesity on hypothalamic microRNAs: from pathophysiology to gene therapy approach" (THESIS/DISSERTATION)
 17
2013
Concluded
 Licenciatura em Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 16
Affiliation

Others

Category
Host institution 		Employer
2017/02/01 - Current PhD Student with Scholarship Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017 - 2018 Student CNC.IBILI, Portugal
2014/09/01 - 2015/09/01 Thesis Project (12 meses): Impact of obesity on hypothalamic microRNAs: from pathophysiology to gene therapy approach Orientadores: Lígia Sousa–Ferreira e Cláudia Cavadas CNC.IBILI, Portugal
Projects

Other

Designation Funders
2018/09/01 - 2021/05/31 NiNjA - New Neuroendocrine Strategy for healthy Aging
POCI-01-0145-FEDER-030167
Other
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Journal article
  1. Leal, Helena; Carvalhas-Almeida, Catarina; Álvaro, Ana Rita; Cavadas, Cláudia. "Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders". Trends in Endocrinology & Metabolism (2024): http://dx.doi.org/10.1016/j.tem.2024.01.001.
    In press • 10.1016/j.tem.2024.01.001
  2. Leal, Helena; Cardoso, João; Valério, Patrícia; Quatorze, Marta; Carmona, Vítor; Cunha-Santos, Janete; Pereira de Almeida, Luís; et al. "SIRT2 Deficiency Exacerbates Hepatic Steatosis via a Putative Role of the ER Stress Pathway". International Journal of Molecular Sciences 23 12 (2022): 6790. http://dx.doi.org/10.3390/ijms23126790.
    Published • 10.3390/ijms23126790
  3. Gomes, Pedro; Leal, Helena; Mendes, Alexandrina F.; Reis, Flávio; Cavadas, Cláudia. "Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases". Trends in Pharmacological Sciences 40 12 (2019): 1021-1039. http://dx.doi.org/10.1016/j.tips.2019.09.003.
    10.1016/j.tips.2019.09.003
  4. Marques, Ana Patrícia; Cunha-Santos, Janete; Leal, Helena; Sousa-Ferreira, Lígia; Pereira de Almeida, Luís; Cavadas, Cláudia; Rosmaninho-Salgado, Joana. "Dipeptidyl peptidase IV (DPP-IV) inhibition prevents fibrosis in adipose tissue of obese mice". Biochimica et Biophysica Acta (BBA) - General Subjects 1862 3 (2018): 403-413. http://dx.doi.org/10.1016/j.bbagen.2017.11.012.
    10.1016/j.bbagen.2017.11.012
Activities

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/02/05 - 2020/02/07 Oral Presentation - Development of in vitro approaches to evaluate hypothalamic insulin signaling in metabolic dysfunctions Reunião Sociedade Portuguesa de Farmacologia 2020
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/12/05 - 2019/12/31 Advanced Course - "The essential of Data Management in Research” from NAU
Other
 The essential of Data Management in Research
2019/11/24 - 2019/11/30 Science & Technology Week
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/02/06 - 2019/02/08 Oral Presentation - Sirtuin 2 deficiency triggers hepatic lipid accumulation through ER stress-dependent pathway Reunião Sociedade Portuguesa de Farmacologia 2019
Universidade do Porto Faculdade de Farmácia, Portugal
2018/10/02 - 2018/10/04 “Hack 4 Ageing Well”, of the Active and Assisted Living Programme Hack 4 Ageing Well
Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal
2018/09/05 - 2018/09/14 “2018 Summer School in Computational Biology”
Other
 2018 Summer School in Computational Biology
Universidade de Coimbra, Portugal
2018/04/10 - 2018/05/16 IneoStart’18 programme IneoStart’18
Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal
2018/05/05 - 2018/05/06 "HACK FOR GOOD" - hackathon HACK FOR GOOD
Fundação Calouste Gulbenkian, Portugal
2017/09/26 - 2017/10/06 Animal Experimentation Course - “Modular Structure Training in Laboratory Animal Science”, Level A + Modules 20,21 and 22
Other
 Modular Structure Training in Laboratory Animal Science
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

CNC.IBILI, Portugal
2017/05/15 - 2017/05/26 Advanced Course - “Principles and Practice in Drug Development”, of the MIT-Portugal program 2015/2016
Other
 Principles and Practice in Drug Development
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/05/04 - 2017/05/06 Hands-on activities at the “i9agri – First Innivation Agriffod Fair in Portugal”, at the Centro de Exposições e Eventos da AEBB, Castelo Branco, Portugal
Exhibition
 i9agri – First Innivation Agriffod Fair in Portugal
2017/04/10 - 2017/04/13 Advanced Course - “Advanced Course in Science Communication and Soft skills” from the Doctoral Program in Experimental Biology and Biomedicine
Other
 dvanced Course in Science Communication and Soft skills
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/03/06 - 2017/03/10 Advanced Course - “Metabolism and Disease: Causes and Consequences of Non-Alcoholic Fatty Liver Disease (NAFLD)”, from the Doctoral Program in Experimental Biology and Biomedicine
Other
 Metabolism and Disease: Causes and Consequences of Non-Alcoholic Fatty Liver Disease (NAFLD)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/01/09 - 2015/01/09 Entrepreneurship activities for researchers - “IPN CNC Business Idea Acceleration”, at Instituto Pedro Nunes, Coimbra, January 9, 2015.
Other
 IPN CNC Business Idea Acceleration
Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal
2015/01/05 - 2015/01/06 Advanced Course - “Neuroepigenetics”, from the Doctoral Program in Experimental Biology and Biomedicine
Other
 Neuroepigenetics
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/12/15 - 2014/12/16 Poster Presentation - miRNA dysfunction in obesity and implications in hypothalamic neurogenesis
Meeting
 XII CNC meeting
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Mentoring / Tutoring

Topic Student name
2018/05/21 - 2018/05/28 Class in a laboratory context Bachelor's students of Biomedical Pharmacy
Distinctions

Other distinction

2017 2º Prémio no “Hack 4 Ageing Well”, ao abrigo do Active and Assisted Living Programme promovido pelo Instituto Pedro Nunes;
2016 PhD Scholarship_SFRH/BD/121923/2016
Fundação para a Ciência e a Tecnologia, Portugal