???global.info.a_carregar???
Iva Pashkuleva has a PhD in Organic Chemistry from University of Sofia, Bulgaria. In 2002, she moved to University of Minho, Portugal where started research activities in the area of Biomaterials - she was awarded a Postdoctoral fellowship from Portuguese Foundation for Science and Technology (FCT) to develop her project on surface characterization and modification of starch-based biomaterials. In 2008, she received Career Starting Grant under the Portuguese National Program Compromisso com a Ciência. During this period, Pashkuleva kept her research focus on surface modification of biomaterials (with emphasis on starch and chitosan) as a way to enhance their biocompatibility. She was principal investigator (PI) of two European projects that enabled her to build own network of international collaborations both in academy and industry. In the following period, she was awarded two Development Career Grants: in 2013 under the Portuguese Program Investigador FCT and in 2019 under the programme for Individual Scientific Employment Stimulus. During this last period, Pashkuleva established a new research line focussed on biofunctional glycans and built a small research team, whose core is currently composed by 1 Research associate, 2 Junior researchers, and 2 PhD students. Pashkuleva and her team are working on the elucidation of glycans role in cellular communication and the possibility to explore glycans in design and synthesis of functional biomaterials. They have developed new analytical methods and platforms for characterization of challenging to measure glycan-protein and glycan-cell interactions. Advancements in glycan-based delivery systems were achieved by development of new designs and concepts. The use of glycans in cancer therapies was also explored: for the first-time glycan amphiphiles were used as substrates in selective biocatalytic approach. Extracellular supramolecular mimics were generated by self-assembly of glycans and proteins or their functional simpler analogues carbohydrates and peptides. As PI and Co-PI she successfully obtained funding from FCT and EC in a total amount of approx 5M euros. She has also participated in proposals preparation and research teams of National granted Projects corresponding to a total budget of about 0.87M euros and EC projects corresponding to a total budget of over 3.52M euros. Her expertise has been recognised by different evaluation agencies and peers. She has been acting as a member of different MSc and PhD examination panels and as External Evaluator of Project proposals for EU (H2020, ERA-NET) and different national foundations (Czech Science Foundation, Swiss National Science Foundation, EMPA co-fund programme). During the last years she has been acting as a referee for peer-reviewed journals form Elsevier, Wiley, Taylor & Francis, RSC, ACS. Since 2018, she is an Academic editor for PlosOne, editorial board member of Molecules (MDPI), Cells (MDPI) and a review editor of Frontiers in Bioengineering and Biotechnology. Since 2018, Pashkuleva has been supervisor of 6 MSc students, 6 PhD students, and several postdoctoral researchers. During this period, 3 PhD and 4 MSc students defended their theses under her supervision and now, they are successful professionals in the academy, research centers or in the industry. The training at advanced (PostDoc) level has been well-recompensated as the researchers mentored by her have been very successful in pursuing the prestigious international fellowships such as Marie Curie and Ramon y Cajal, but also competitive national grants (FCT CEEC: 2 Junior, 2 Auxiliar and 1 Development grants). Pashkuleva is an elected member of the General Council of the Research Institute of Biomaterials, Biodegradables and Biomimetics (I3Bs) and the Quality Assurance team of the same Institute. She also takes part of the PhD programme in Tissue engineering, regenerative medicine (TERM) and stem cells as well as of the UMinho online course in TERM.
Identification

Personal identification

Full name
Iva Pashkuleva

Citation names

  • Pashkuleva, Iva

Author identifiers

Ciência ID
A61F-4AAC-1C34
ORCID iD
0000-0001-6818-3374
Google Scholar ID
https://scholar.google.pt/citations?user=5NL6DDwAAAAJ&hl=en
Researcher Id
B-5590-2008
Scopus Author Id
57197790406

Telephones

Telephone
  • 253510 Ext.: 906 (Professional)

Addresses

  • AvePark, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal (Professional)

Websites

Knowledge fields

  • Engineering and Technology - Materials Engineering
  • Engineering and Technology - Nano-technology - Nano-materials
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials

Languages

Language Speaking Reading Writing Listening Peer-review
Bulgarian (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Upper intermediate (B2) Advanced (C1) Elementary (A2) Upper intermediate (B2)
Russian Elementary (A2) Upper intermediate (B2) Elementary (A2) Intermediate (B1)
Education
Degree Classification
2001 - 2007
Concluded
Biomaterials (Pós-doutoramento)
Major in Surface modification of starch-based biomaterials
Universidade do Minho, Portugal
1996 - 2000
Concluded
Organic chemistry (Doctor of Philosophy)
Sofiski universitet Sveti Kliment Ohridski, Bulgaria
"Reaction of Schiff bases of benzylamine with some derivatives of cinnamic acid and azomethines under phase-transfer catalysed conditions" (THESIS/DISSERTATION)
1990 - 1995
Concluded
Organic and Analytical Chemistry (Master)
Sofiski universitet Sveti Kliment Ohridski, Bulgaria
"Addition of ethyl N-(diphenylmethylene)glycinate to azomethines under phase-transfer catalysed conditions" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution
Employer
2013/12/16 - Current Principal Investigator (Research) Universidade do Minho, Portugal
2008 - 2013 Auxiliary Researcher (Research) Universidade do Minho, Portugal
2001 - 2007 Postdoc (Research) Universidade do Minho, Portugal
Universidade do Minho Departamento de Engenharia de Polímeros, Portugal
1999 - 2000 Researcher (Research) Balgarska academija na naukite, Bulgaria

Teaching in Higher Education

Category
Host institution
Employer
2000 - 2001 Assistant Professor (University Teacher) Sofiski universitet Sveti Kliment Ohridski, Bulgaria
1996 - 1999 Invited Assistant (University Teacher) Sofiski universitet Sveti Kliment Ohridski, Bulgaria
Projects

Grant

Designation Funders
2020 - 2024 Bioadhesive materials for spinal cord regeneration
SFRH/BD/143209/2019
Supervisor
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017 - 2021 NANOGLYCAN: Glycotools for elucidating molecular and cellular interaction of glycans in vitro
SFRH/BD/114847/2016
Supervisor
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2013/03/01 - 2019 SULFOCODE: SURFACES MIMICKING SULFONATED GAGS AS PLATFORMS FOR STUDYING THE MECHANISMS BEHIND CELL-GAGS INTERACTIONS
SFRH/BPD/85790/2012
Supervisor
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2022/12 - 2027/11 APTADEGRAD: A novel, first-in-its-kind, aptamer-based LYTACs to address the unmet clinical need of diabetic wounds
Principal investigator
Horizon 2020
Ongoing
2022/01/01 - 2024/12/31 SpyPatch: Modular spider silk and elastin recombinamers for soft tissue repair patches
PTDC/BTM-MAT/2844/2021
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01 - 2024/12 OncoNeoTreat: Inorganic-Templated and Polymeric Layer-by-Layer Microcapsules with Multimodal Drug Loading to Treat Breast Cancer
PTDC/CTM-REF/0022/2020
Co-Principal Investigator (Co-PI)
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 CardioHeal: Self-healing hydrogels with extracellular matrix analogues for cardiac tissue engineering
PTDC/BTM-MAT/28327/2017
Principal investigator
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 CARTI-LIKE: Reconstruction of cartilage nanostructure by brush like copolymers that mimic proteoglycans
PTDC/QUI-POL/28117/2017
Co-Principal Investigator (Co-PI)
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 CANCER_CAGE: Smart carbohydrate nanonets for selective anticancer therapies
PTDC/NAN-MAT/28468/2017
2018-2020 Co-PI; 2021 Researcher
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 SeaJellyBone: Multifunctional hydrogels inspired by mussels that combine bioactivity with superior adhesion for bone tissue regeneration
PTDC/BTM-MAT/28123/2017
Researcher
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 Bioactive coatings containing new BioGlass nanoparticles for orthopedic applications
PTDC/NAN-MAT/31036/2017
Researcher
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01 - 2020/12 GLYCONET: Depriving cancer glycolysis by aromatic N-glucosides that act as GLUT1 antagonists and substrates for biocatalytic self-assembly
LPCC-NRN 2020
Principal investigator
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte
Concluded
2015/06 - 2019/05 ELASTISLET: Tailored elastin-like recombinamers as advanced systems for cell therapies in diabetes mellitus: a synthetic biology approach towards a bioeffective and immunoisolated biosimilar islet/cell niche
Researcher
Universidade do Minho, Portugal
Horizon 2020
Concluded
2016/01 - 2018/12 CHEM2NATURE: Enabling precision chemical methodologies applied to natural-based systems for the development of multifunctional biomedical devices
Universidade do Minho, Portugal
Horizon 2020
Concluded
2016 - 2018 CytoNanoHeal: Engineered nanotools for advanced cell therapies
ENMed/0001/2015
Principal investigator
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014 - 2018 SWEETLIFE: Glycans as a third language of life beyond proteins and nucleic acid
IF/00032/2013
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
2012/10 - 2015/09 POLARIS: Unlocking the research potential of 3Bs Group, University of Minho, in Nanomedicine field to stengthen its competitive position at the European level
Supervisor
Universidade do Minho, Portugal
European Commission
Concluded
2011/01 - 2013/12 EpitHope - Advanced Biomimetic Regenerative Strategies for Active Targeting Degenerative Articular Cartilage
PTDC/EBB-BIO/114523/2009
Researcher
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/04 - 2013/09 TISSUE2TISSUE-Using Textile Technologies to Develop Innovative 3D Architectures to Be Applied in Bone Tissue Engineering
Researcher
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/10 - 2013/09 Find and Bind: Mastering sweet cell-instructive biosystems by copycat nano-interaction of cells with natural surfaces for biotechnological application
Principal investigator
Universidade do Minho, Portugal
European Commission
Concluded
2007/04 - 2010/03 PhotoNanoTech: Photozyme Nanoparticle Applications for Water Purification, Textile Finishing, Photodynamic Biomineralization and Biomaterials Coating
Principal investigator
Universidade do Minho, Portugal
European Commission
Concluded
2005/01 - 2008/05 SMARTSCAFF- Polymeric 3D Scaffolds with Tailor-Made Surfaces for Bone Tissue Engineering
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Costa, Rui R.; Reis, Rui L.; Pashkuleva, Iva. "Hydrogels formed by polyelectrolyte complexation". In Hydrogels for Tissue Engineering and Regenerative Medicine, 311-330. Elsevier, 2024.
    10.1016/b978-0-12-823948-3.00008-7
  2. Soares da Costa, Diana; Brito, Alexandra; Pashkuleva, Iva. Corresponding author: Pashkuleva, Iva. "Supramolecular assemblies of glycopeptides as mimics of the extracellular matrix". In Multifunctional hydrogels for biomedical applications, edited by Pires, Ricardo A; Reis, Rui L.; Pashkuleva, Iva, 149-179. Weinheim, Germany: WILEY-VCH GmbH, 2022.
    Published
  3. Pashkuleva, Iva. "Hydrogel Nanomaterials for Cancer Diagnosis and Therapy". In Hydrogels Design, Synthesis and Application in Drug Delivery and Regenerative Medicine. 2018.
    Published
  4. Brito, Alexandra; Reis, Rui L.; Pires, Ricardo A.; Pashkuleva, Iva. "Sweet building blocks for self-assembling biomaterials with molecular recognition". In Self-assembling Biomaterials, 79-94. Elsevier, 2018.
    10.1016/b978-0-08-102015-9.00005-8
  5. Alves, N.M.; Pashkuleva, I.; Reis, R.L.; Mano, J.F.. "Polymer Patterns and Scaffolds for Biomedical Applications and Tissue Engineering". In Generating Micro- and Nanopatterns on Polymeric Materials, 291-302. 2011.
    Published • 10.1002/9783527633449.ch13
  6. Pashkuleva, I.; López-Pérez, P.M.; Reis, R.L.. "Surface modification of natural-based biomedical polymers". In Natural-Based Polymers for Biomedical Applications, 165-192. 2008.
    Published • 10.1533/9781845694814.2.165
Conference abstract
  1. Pashkuleva, Iva. "Co-assembly of peptide and carbohydrate amphiphiles to generate proteoglycan mimics". Paper presented in 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, Boston, 2018.
    Published
  2. Pashkuleva, Iva. "Short carbohydrate amphiphiles as smart therapeutics targeting cancer". Paper presented in 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, Boston, 2018.
    Published
  3. Pashkuleva, Iva. "Hyaluronan density influences adhesion, morphology and migration of cancer cells". Paper presented in 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, Boston, 2018.
    Published
Conference paper
  1. Chiono, V.; Carmagnola, I.; Gentile, P.; Boccafoschi, F.; Tonda-Turo, C.; Ciardelli, G.; Georgiev, G.; et al. "Layer-by-layer coating of photoactive polymers for biomedical applications". 2009.
Journal article
  1. Diogo Duarte; Cátia Correia; Rui L. Reis; Iva Pashkuleva; Daniela Peixoto; Natália M. Alves. "Bioadhesive Hyaluronic Acid-Based Hydrogels for Spinal Cord Injury". Biomacromolecules (2024): https://doi.org/10.1021/acs.biomac.3c01186.
    10.1021/acs.biomac.3c01186
  2. Fontelo, Raul; Reis, Rui L.; Novoa-Carballal, Ramon; Pashkuleva, Iva. "Preparation, Properties, and Bioapplications of Block Copolymer Nanopatterns". Advanced Healthcare Materials 13 1 (2023): http://dx.doi.org/10.1002/adhm.202301810.
    10.1002/adhm.202301810
  3. Bastos, Filipa R.; Soares da Costa, Diana; Reis, Rui L.; Alves, Natália M.; Pashkuleva, Iva; Costa, Rui R.. "Layer-by-layer coated calcium carbonate nanoparticles for targeting breast cancer cells". Biomaterials Advances 153 (2023): 213563. http://dx.doi.org/10.1016/j.bioadv.2023.213563.
    Published • 10.1016/j.bioadv.2023.213563
  4. Amaral, Sandra; Lozano-Fernández, Tamara; Sabin, Juan; Gallego, Amanda; da Silva Morais, Alain; Reis, Rui L.; González-Fernández, África; Pashkuleva, Iva; Novoa-Carballal, Ramon. "End-on PEGylation of heparin: Effect on anticoagulant activity and complexation with protamine". International Journal of Biological Macromolecules 249 (2023): 125957. http://dx.doi.org/10.1016/j.ijbiomac.2023.125957.
    Published • 10.1016/j.ijbiomac.2023.125957
  5. Rui R. Costa; David Caballero; Diana Soares da Costa; Romen Rodriguez-Trujillo; Subhas C. Kundu; Rui L. Reis; Iva Pashkuleva. "Microfluidic-Assisted Interfacial Complexation of Extracellular Matrix Components to Mimic the Properties of Neural Tissues". Advanced Materials Technologies (2023): https://doi.org/10.1002/admt.202300983.
    10.1002/admt.202300983
  6. Vânia I.B. Castro; Ana R. Araújo; Filipa Duarte; António Sousa-Franco; Rui L. Reis; Iva Pashkuleva; Ricardo A. Pires. "Glycopeptide-Based Supramolecular Hydrogels Induce Differentiation of Adipose Stem Cells into Neural Lineages". ACS Applied Materials & Interfaces (2023): https://doi.org/10.1021/acsami.3c05309.
    10.1021/acsami.3c05309
  7. Cátia Correia; Rui L. Reis; Iva Pashkuleva; Natália M. Alves. "Adhesive and self-healing materials for central nervous system repair". Biomaterials Advances (2023): 213439-213439. http://dx.doi.org/10.1016/j.bioadv.2023.213439.
    10.1016/j.bioadv.2023.213439
  8. Ana M. Martins; Alexandra Brito; Maria Grazia Barbato; Alessia Felici; Rui L. Reis; Ricardo A. Pires; Iva Pashkuleva; Paolo Decuzzi. "Efficacy of molecular and nano-therapies on brain tumor models in microfluidic devices". Biomaterials Advances 144 (2023): 213227-213227. http://dx.doi.org/10.1016/j.bioadv.2022.213227.
    10.1016/j.bioadv.2022.213227
  9. Cátia Correia; Diana Soares da Costa; Ana Rita Inácio; A. Catarina Vale; Daniela Peixoto; Tiago H. Silva; Rui L. Reis; Iva Pashkuleva; Natália M. Alves. "Adhesive and Antibacterial Films Based on Marine-Derived Fucoidan and Chitosan". ACS Sustainable Chemistry & Engineering (2022): https://doi.org/10.1021/acssuschemeng.2c05144.
    10.1021/acssuschemeng.2c05144
  10. Ana M. Carvalho; Rui L. Reis; Iva Pashkuleva. "Hyaluronan Receptors as Mediators and Modulators of the Tumor Microenvironment". Advanced Healthcare Materials (2022): https://doi.org/10.1002/adhm.202202118.
    10.1002/adhm.202202118
  11. Ana M. Carvalho; Jesus Valcarcel; Diana Soares da Costa; Marisa Gomes; José Antonio Vázquez; Rui L. Reis; Ramon Novoa-Carballal; Iva Pashkuleva. "Hyaluronan Brush-like Copolymers Promote CD44 Declustering in Breast Cancer Cells". ACS Applied Materials & Interfaces (2022): https://doi.org/10.1021/acsami.2c11864.
    10.1021/acsami.2c11864
  12. Ana M. Carvalho; Diana Soares da Costa; Rui L. Reis; Iva Pashkuleva. "RHAMM expression tunes the response of breast cancer cell lines to hyaluronan". Acta Biomaterialia (2022): https://doi.org/10.1016/j.actbio.2022.05.013.
    10.1016/j.actbio.2022.05.013
  13. Correia, Cátia; Sousa, Rita O.; Vale, A. Catarina; Peixoto, Daniela; Silva, Tiago H.; Reis, Rui L.; Pashkuleva, Iva; Alves, Natália M.. "Adhesive and biodegradable membranes made of sustainable catechol-functionalized marine collagen and chitosan". Colloids and Surfaces B: Biointerfaces 213 (2022): 112409. http://dx.doi.org/10.1016/j.colsurfb.2022.112409.
    10.1016/j.colsurfb.2022.112409
  14. Fontelo, R.; Soares da Costa, D.; Reis, R.L.; Novoa-Carballal, R.; Pashkuleva, I.. "Antithrombotic and hemocompatible properties of nanostructured coatings assembled from block copolymers". Journal of Colloid and Interface Science 608 (2022): 1608-1618. http://dx.doi.org/10.1016/j.jcis.2021.10.076.
    10.1016/j.jcis.2021.10.076
  15. Rui R. Costa; Rui L. Reis; Iva Pashkuleva. "Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices". International Materials Reviews (2022): https://doi.org/10.1080/09506608.2022.2026860.
    10.1080/09506608.2022.2026860
  16. Raul Fontelo; Diana Soares da Costa; Manuel Gomez-Florit; Hanna Tiainen; Rui L. Reis; Ramon Novoa-Carballal; Iva Pashkuleva. "Antibacterial nanopatterned coatings for dental implants". Journal of Materials Chemistry B (2022): https://doi.org/10.1039/D2TB01352E.
    10.1039/D2TB01352E
  17. Alexandra Brito; Dhwanit Dave; Ayala Lampel; Vânia I. B. Castro; Daniela Kroiss; Rui L. Reis; Tell Tuttle; et al. "Expanding the Conformational Landscape of Minimalistic Tripeptides by Their O-Glycosylation". Journal of the American Chemical Society (2021): https://doi.org/10.1021/jacs.1c07592.
    10.1021/jacs.1c07592
  18. Ana M. Carvalho; Diana Soares da Costa; Rui L. Reis; Iva Pashkuleva. "Influence of Hyaluronan Density on the Behavior of Breast Cancer Cells with Different CD44 Expression". Advanced Healthcare Materials (2021): 2101309-2101309. https://doi.org/10.1002/adhm.202101309.
    10.1002/adhm.202101309
  19. Pashkuleva, Iva. "Liposomes embedded in layer by layer constructs as simplistic extracellular vesicles transfer model". Materials Science and Engineering: C 121 (2021): 111813-111813. http://dx.doi.org/10.1016/j.msec.2020.111813.
    10.1016/j.msec.2020.111813
  20. Amorim, Sara; Soares da Costa, Diana; Mereiter, Stefan; Pashkuleva, Iva; Reis, Celso A.; Reis, Rui L.; Pires, Ricardo A.. "Multilayer platform to model the bioactivity of hyaluronic acid in gastric cancer". Materials Science and Engineering: C 119 (2021): 111616. http://dx.doi.org/10.1016/j.msec.2020.111616.
    10.1016/j.msec.2020.111616
  21. Ana M. Carvalho; Diana Soares da Costa; Pedro M.R. Paulo; Rui L. Reis; Iva Pashkuleva. "Co-localization and crosstalk between CD44 and RHAMM depend on hyaluronan presentation". Acta Biomaterialia 119 (2021): 114-124. http://dx.doi.org/10.1016/j.actbio.2020.10.024.
    10.1016/j.actbio.2020.10.024
  22. Amorim, Sara; Soares da Costa, Diana; Pashkuleva, Iva; Reis, Celso A.; Reis, Rui L.; Pires, Ricardo A.; Sara Amorim; et al. "3D hydrogel mimics of the tumor microenvironment: the interplay among hyaluronic acid, stem cells and cancer cells". Biomaterials Science 9 1 (2021): 252-260. http://dx.doi.org/10.1039/d0bm00843e.
    10.1039/d0bm00843e
  23. Amorim, Sara; Soares da Costa, Diana; Pashkuleva, Iva; Reis, Celso A.; Reis, Rui L.; Pires, Ricardo A.. "Hyaluronic Acid of Low Molecular Weight Triggers the Invasive “Hummingbird” Phenotype on Gastric Cancer Cells". Advanced Biosystems 4 11 (2020): 2000122. http://dx.doi.org/10.1002/adbi.202000122.
    10.1002/adbi.202000122
  24. Yankova, Iveta; Shestakova, Pavletta; Reis, Rui L.; Pashkuleva, Iva; Vassileva, Elena. "Gelatin micro- and nanocapsules obtained via sonochemical method". Journal of Applied Polymer Science 137 48 (2020): 49584. http://dx.doi.org/10.1002/app.49584.
    10.1002/app.49584
  25. Soares da Costa, Diana; Sousa, João C.; Dá Mesquita, Sandro; Petkova-Yankova, Nevena I.; Marques, Fernanda; Reis, Rui L.; Sousa, Nuno; Pashkuleva, Iva. "Bioorthogonal Labeling Reveals Different Expression of Glycans in Mouse Hippocampal Neuron Cultures during Their Development". Molecules 25 4 (2020): 795. http://dx.doi.org/10.3390/molecules25040795.
    Published • 10.3390/molecules25040795
  26. Alexandra Brito; Patrícia M. R. Pereira; Diana Soares da Costa; Rui L. Reis; Rein V. Ulijn; Jason S. Lewis; Ricardo A. Pires; Iva Pashkuleva. "Inhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as antagonists of the glucose transporter GLUT1". Chemical Science (2020): https://doi.org/10.1039/D0SC00954G.
    10.1039/D0SC00954G
  27. Sara Amorim; Iva Pashkuleva; Celso A. Reis; Rui L. Reis; Ricardo A. Pires. "Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44". Journal of Materials Chemistry B (2020): https://doi.org/10.1039/D0TB00407C.
    10.1039/D0TB00407C
  28. Alexandra Brito; Patrícia M. R. Pereira; Rui L. Reis; Rein V. Ulijn; Jason S. Lewis; Ricardo A. Pires; Iva Pashkuleva. "Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse". Nanoscale (2020): https://doi.org/10.1039/D0NR05008C.
    10.1039/D0NR05008C
  29. Ramón Rial; Rui R. Costa; Rui L. Reis; Zhen Liu; Iva Pashkuleva; Juan M. Ruso. "Mineralization of Layer-by-Layer Ultrathin Films Containing Microfluidic-Produced Hydroxyapatite Nanorods". Crystal Growth & Design (2019): https://doi.org/10.1021/acs.cgd.9b00831.
    10.1021/acs.cgd.9b00831
  30. Costa, Rui R.; Soares da Costa, Diana; Reis, Rui L.; Pashkuleva, Iva. "Bioinspired baroplastic glycosaminoglycan sealants for soft tissues". Acta Biomaterialia 87 (2019): 108-117. http://dx.doi.org/10.1016/j.actbio.2019.01.040.
    10.1016/j.actbio.2019.01.040
  31. Alexandra Brito; Yousef M. Abul-Haija; Diana Soares da Costa; Ramon Novoa-Carballal; Rui L. Reis; Rein V. Ulijn; Ricardo A. Pires; Iva Pashkuleva. "Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles". Chemical Science (2019): https://doi.org/10.1039/C8SC04361B.
    10.1039/C8SC04361B
  32. Sara Amorim; Diana Soares da Costa; Daniela Freitas; Celso A. Reis; Rui L. Reis; Iva Pashkuleva; Ricardo A. Pires. "Molecular weight of surface immobilized hyaluronic acid influences CD44-mediated binding of gastric cancer cells". Scientific Reports (2018): https://doi.org/10.1038/s41598-018-34445-0.
    10.1038/s41598-018-34445-0
  33. Ramon Novoa-Carballal; Agatha Carretero; Raul Pacheco; Rui L. Reis; Iva Pashkuleva. "Star-Like Glycosaminoglycans with Superior Bioactivity Assemble with Proteins into Microfibers". Chemistry - A European Journal 24 54 (2018): 14341-14345. https://doi.org/10.1002/chem.201802243.
    10.1002/chem.201802243
  34. Rui R. Costa; Miguel González-Pérez; Marcos Herrero-Gutiérrez; Ricardo A. Pires; Matilde Alonso; J. Carlos Rodriguez-Cabello; Rui L. Reis; Iva Pashkuleva. "Tuning the Stiffness of Surfaces by Assembling Genetically Engineered Polypeptides with Tailored Amino Acid Sequence". Biomacromolecules (2018): https://doi.org/10.1021/acs.biomac.8b00723.
    10.1021/acs.biomac.8b00723
  35. Ana M. Carvalho; Raquel Teixeira; Ramón Novoa-Carballal; Ricardo A. Pires; Rui L. Reis; Iva Pashkuleva. "Redox-Responsive Micellar Nanoparticles from Glycosaminoglycans for CD44 Targeted Drug Delivery". Biomacromolecules (2018): https://doi.org/10.1021/acs.biomac.8b00561.
    10.1021/acs.biomac.8b00561
  36. Soares Da Costa, D.; Reis, R.L.; Pashkuleva, I.. "Sulfation of Glycosaminoglycans and Its Implications in Human Health and Disorders". Annual Review of Biomedical Engineering 19 (2017): 1-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021172739&partnerID=MN8TOARS.
    Published • 10.1146/annurev-bioeng-071516-044610
  37. Silva, C.; Carretero, A.; Soares da Costa, D.; Reis, R.L.; Novoa-Carballal, R.; Pashkuleva, I.. "Design of protein delivery systems by mimicking extracellular mechanisms for protection of growth factors". Acta Biomaterialia 63 (2017): 283-293. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029607589&partnerID=MN8TOARS.
    10.1016/j.actbio.2017.08.042
  38. Oliveira, C.; Ferreira, A.S.; Novoa-Carballal, R.; Nunes, C.; Pashkuleva, I.; Neves, N.M.; Coimbra, M.A.; et al. "The Key Role of Sulfation and Branching on Fucoidan Antitumor Activity". Macromolecular Bioscience 17 5 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85009179205&partnerID=MN8TOARS.
    10.1002/mabi.201600340
  39. Ribeiro, V.P.; Almeida, L.R.; Martins, A.R.; Pashkuleva, I.; Marques, A.P.; Ribeiro, A.S.; Silva, C.J.; et al. "Modulating cell adhesion to polybutylene succinate biotextile constructs for tissue engineering applications". Journal of Tissue Engineering and Regenerative Medicine 11 10 (2017): 2853-2863. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978872476&partnerID=MN8TOARS.
    10.1002/term.2189
  40. A. Carretero; D. Soares da Costa; R. L. Reis; I. Pashkuleva; Carretero, A.; Soares Da Costa, D.; Reis, R.L.; Pashkuleva, I.. "Extracellular matrix-inspired assembly of glycosaminoglycan–collagen fibers". Journal of Materials Chemistry B 5 17 (2017): 3103-3106. https://doi.org/10.1039/C7TB00704C.
    10.1039/C7TB00704C
  41. Teixeira, R.; Reis, R.L.; Pashkuleva, I.. "Influence of the sulfation degree of glycosaminoglycans on their multilayer assembly with poly-l-lysine". Colloids and Surfaces B: Biointerfaces 145 (2016): 567-575. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973130037&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2016.05.069
  42. Araújo, A.R.; Soares Da Costa, D.; Amorim, S.; Reis, R.L.; Pires, R.A.; Pashkuleva, I.. "Surfaces Mimicking Glycosaminoglycans Trigger Different Response of Stem Cells via Distinct Fibronectin Adsorption and Reorganization". ACS Applied Materials and Interfaces 8 42 (2016): 28428-28436. http://www.scopus.com/inward/record.url?eid=2-s2.0-84993994713&partnerID=MN8TOARS.
    10.1021/acsami.6b04472
  43. Ribeiro, V.P.; Almeida, L.R.; Martins, A.R.; Pashkuleva, I.; Marques, A.P.; Ribeiro, A.S.; Silva, C.J.; et al. "Influence of different surface modification treatments on silk biotextiles for tissue engineering applications". Journal of Biomedical Materials Research - Part B Applied Biomaterials 104 3 (2016): 496-507. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959905440&partnerID=MN8TOARS.
    10.1002/jbm.b.33400
  44. Yang, Y.; Köwitsch, A.; Ma, N.; Mäder, K.; Pashkuleva, I.; Reis, R.L.; Groth, T.. "Functionality of surface-coupled oxidised glycosaminoglycans towards fibroblast adhesion". Journal of Bioactive and Compatible Polymers 31 2 (2016): 191-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958527301&partnerID=MN8TOARS.
    10.1177/0883911515599999
  45. Francesko, A.; Fernandes, M.M.; Ivanova, K.; Amorim, S.; Reis, R.L.; Pashkuleva, I.; Mendoza, E.; et al. "Bacteria-responsive multilayer coatings comprising polycationic nanospheres for bacteria biofilm prevention on urinary catheters". Acta Biomaterialia 33 (2016): 203-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959554715&partnerID=MN8TOARS.
    10.1016/j.actbio.2016.01.020
  46. Azevedo, H.S.; Pashkuleva, I.. "Biomimetic supramolecular designs for the controlled release of growth factors in bone regeneration". Advanced Drug Delivery Reviews 94 (2015): 63-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947612097&partnerID=MN8TOARS.
    10.1016/j.addr.2015.08.003
  47. Pires, R.A.; Abul-Haija, Y.M.; Costa, D.S.; Novoa-Carballal, R.; Reis, R.L.; Ulijn, R.V.; Pashkuleva, I.. "Controlling cancer cell fate using localized biocatalytic self-assembly of an aromatic carbohydrate amphiphile". Journal of the American Chemical Society 137 2 (2015): 576-579. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921457793&partnerID=MN8TOARS.
    10.1021/ja5111893
  48. Silva, C.; Novoa-Carballal, R.; Reis, R.L.; Pashkuleva, I.. "Following the enzymatic digestion of chondroitin sulfate by a simple GPC analysis". Analytica Chimica Acta 885 (2015): 207-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952874606&partnerID=MN8TOARS.
    10.1016/j.aca.2015.05.034
  49. Soares Da Costa, D.; Márquez-Posadas, M.D.C.; Araujo, A.R.; Yang, Y.; Merino, S.; Groth, T.; Reis, R.L.; Pashkuleva, I.. "Adhesion of adipose-derived mesenchymal stem cells to glycosaminoglycan surfaces with different protein patterns". ACS Applied Materials and Interfaces 7 18 (2015): 10034-10043. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929180016&partnerID=MN8TOARS.
    10.1021/acsami.5b02479
  50. Pires, Ricardo A.; Leonor, Isabel B.; Pashkuleva, Iva; Reis, Rui L.. "Research Highlights: Highlights from the latest articles in nanomedicine". Nanomedicine (London, England) 9 5 (2014): 573-6.
    10.2217/nnm.14.29
  51. Novoa-Carballal, R.; Silva, C.; Möller, S.; Schnabelrauch, M.; Reis, R.L.; Pashkuleva, I.. "Tunable nano-carriers from clicked glycosaminoglycan block copolymers". Journal of Materials Chemistry B 2 26 (2014): 4177-4184. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902241807&partnerID=MN8TOARS.
    10.1039/c4tb00410h
  52. Francesko, A.; Soares Da Costa, D.; Reis, R.L.; Pashkuleva, I.; Tzanov, T.. "Functional biopolymer-based matrices for modulation of chronic wound enzyme activities". Acta Biomaterialia 9 2 (2013): 5216-5225. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872063730&partnerID=MN8TOARS.
    10.1016/j.actbio.2012.10.014
  53. Márquez-Posadas, M.C.; Ramiro, J.; Becher, J.; Yang, Y.; Köwitsch, A.; Pashkuleva, I.; Díez-Ahedo, R.; et al. "Surface microstructuring and protein patterning using hyaluronan derivatives". Microelectronic Engineering 106 (2013): 21-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874699272&partnerID=MN8TOARS.
    10.1016/j.mee.2013.01.039
  54. Amorim, S.; Pires, R.A.; Da Costa, D.S.; Reis, R.L.; Pashkuleva, I.. "Interactions between exogenous FGF-2 and sulfonic groups: In situ characterization and impact on the morphology of human adipose-derived stem cells". Langmuir 29 25 (2013): 7983-7992. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879543962&partnerID=MN8TOARS.
    10.1021/la400871c
  55. Almeida, L.R.; Martins, A.R.; Fernandes, E.M.; Oliveira, M.B.; Correlo, V.M.; Pashkuleva, I.; Marques, A.P.; et al. "New biotextiles for tissue engineering: Development, characterization and in vitro cellular viability". Acta Biomaterialia 9 9 (2013): 8167-8181. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880924437&partnerID=MN8TOARS.
    10.1016/j.actbio.2013.05.019
  56. Altgärde, N.; Nilebäck, E.; De Battice, L.; Pashkuleva, I.; Reis, R.L.; Becher, J.; Möller, S.; Schnabelrauch, M.; Svedhem, S.. "Probing the biofunctionality of biotinylated hyaluronan and chondroitin sulfate by hyaluronidase degradation and aggrecan interaction". Acta Biomaterialia 9 9 (2013): 8158-8166. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880924599&partnerID=MN8TOARS.
    10.1016/j.actbio.2013.05.031
  57. Francesko, A.; Soares Da Costa, D.; Lisboa, P.; Reis, R.L.; Pashkuleva, I.; Tzanov, T.. "GAGs-thiolated chitosan assemblies for chronic wounds treatment: Control of enzyme activity and cell attachment". Journal of Materials Chemistry 22 37 (2012): 19438-19446. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865740021&partnerID=MN8TOARS.
    10.1039/c2jm31051a
  58. Da Costa, D.S.; Pires, R.A.; Frias, A.M.; Reis, R.L.; Pashkuleva, I.. "Sulfonic groups induce formation of filopodia in mesenchymal stem cells". Journal of Materials Chemistry 22 15 (2012): 7172-7178. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858972552&partnerID=MN8TOARS.
    10.1039/c2jm15762d
  59. Gentile, P.; Mattioli-Belmonte, M.; Chiono, V.; Ferretti, C.; Baino, F.; Tonda-Turo, C.; Vitale-Brovarone, C.; et al. "Bioactive glass/polymer composite scaffolds mimicking bone tissue". Journal of Biomedical Materials Research - Part A 100 A 10 (2012): 2654-2667. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865655900&partnerID=MN8TOARS.
    10.1002/jbm.a.34205
  60. Balmayor, E.R.; Pashkuleva, I.; Frias, A.M.; Azevedo, H.S.; Reis, R.L.. "Synthesis and functionalization of superparamagnetic poly-e- caprolactone microparticles for the selective isolation of subpopulations of human adipose-derived stem cells". Journal of the Royal Society Interface 8 59 (2011): 896-905. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955743379&partnerID=MN8TOARS.
    10.1098/rsif.2010.0531
  61. Pashkuleva, I.; Marques, A.P.; Vaz, F.; Reis, R.L.. "Surface modification of starch based biomaterials by oxygen plasma or UV-irradiation". Journal of Materials Science: Materials in Medicine 21 1 (2010): 21-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-75049086153&partnerID=MN8TOARS.
    10.1007/s10856-009-3831-0
  62. López-Pérez, P.M.; Da Silva, R.M.P.; Sousa, R.A.; Pashkuleva, I.; Reis, R.L.. "Plasma-induced polymerization as a tool for surface functionalization of polymer scaffolds for bone tissue engineering: An in vitro study". Acta Biomaterialia 6 9 (2010): 3704-3712. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956749497&partnerID=MN8TOARS.
    10.1016/j.actbio.2010.03.008
  63. López-Pérez, P.M.; Da Silva, R.M.P.; Pashkuleva, I.; Román, J.S.; Reis, R.L.. "Temperature as a single on-off parameter controlling nanoparticles growing, stabilization and fast disentanglement". Advanced Materials 22 38 (2010): 4288-4292. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957905260&partnerID=MN8TOARS.
    10.1002/adma.201001717
  64. Alves, N.M.; Pashkuleva, I.; Reis, R.L.; Mano, J.F.. "Controlling cell behavior through the design of polymer surfaces". Small 6 20 (2010): 2208-2220. http://www.scopus.com/inward/record.url?eid=2-s2.0-78349278497&partnerID=MN8TOARS.
    10.1002/smll.201000233
  65. Pashkuleva, I.; Reis, R.L.. "Sugars: Burden or biomaterials of the future?". Journal of Materials Chemistry 20 40 (2010): 8803-8818. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957791959&partnerID=MN8TOARS.
    10.1039/c0jm01605e
  66. Tuzlakoglu, K.; Pashkuleva, I.; Rodrigues, M.T.; Gomes, M.E.; Van Lenthe, G.H.; Müller, R.; Reis, R.L.. "A new route to produce starch-based fiber mesh scaffolds by wet spinning and subsequent surface modification as a way to improve cell attachment and proliferation". Journal of Biomedical Materials Research - Part A 92 1 (2010): 369-377. http://www.scopus.com/inward/record.url?eid=2-s2.0-73549114019&partnerID=MN8TOARS.
    10.1002/jbm.a.32358
  67. López-Pérez, P.M.; Da Silva, R.M.P.; Serra, C.; Pashkuleva, I.; Reis, R.L.. "Surface phosphorylation of chitosan significantly improves osteoblast cell viability, attachment and proliferation". Journal of Materials Chemistry 20 3 (2010): 483-491. http://www.scopus.com/inward/record.url?eid=2-s2.0-72949086588&partnerID=MN8TOARS.
    10.1039/b911854c
  68. López-Pérez, P.M.; Da Silva, R.M.P.; Pashkuleva, I.; Parra, F.; Reis, R.L.; San Roman, J.. "Hydrophobic-Electrostatic Balance Driving the LCST Offset Aggregation-Redissolution Behavior of N -Alkylacrylamide-Based Ionic Terpolymers". Langmuir 26 8 (2010): 5934-5941. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950933897&partnerID=MN8TOARS.
    10.1021/la903904t
  69. Pashkuleva, I.; López-Pérez, P.M.; Azevedo, H.S.; Reis, R.L.. "Highly porous and interconnected starch-based scaffolds: Production, characterization and surface modification". Materials Science and Engineering C 30 7 (2010): 981-989. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953958366&partnerID=MN8TOARS.
    10.1016/j.msec.2010.04.019
  70. Martins, A.; Pinho, E.D.; Faria, S.; Pashkuleva, I.; Marques, A.P.; Reis, R.L.; Neves, N.M.. "Surface modification of electrospun polycaprolactone nanofiber meshes by plasma treatment to enhance biological performance". Small 5 10 (2009): 1195-1206. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649892067&partnerID=MN8TOARS.
    10.1002/smll.200801648
  71. Santos, M.I.; Pashkuleva, I.; Alves, C.M.; Gomes, M.E.; Fuchs, S.; Unger, R.E.; Reis, R.L.; Kirkpatrick, C.J.. "Surface-modified 3D starch-based scaffold for improved endothelialization for bone tissue engineering". Journal of Materials Chemistry 19 24 (2009): 4091-4101. http://www.scopus.com/inward/record.url?eid=2-s2.0-67149099423&partnerID=MN8TOARS.
    10.1039/b819089e
  72. Pashkuleva, I.; Azevedo, H.S.; Reis, R.L.. "Surface structural investigation of starch-based biomaterials". Macromolecular Bioscience 8 2 (2008): 210-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-41249096665&partnerID=MN8TOARS.
    10.1002/mabi.200700076
  73. Coutinho, D.F.; Pashkuleva, I.H.; Alves, C.M.; Marques, A.P.; Neves, N.M.; Reis, R.L.. "The effect of chitosan on the in vitro biological performance of chitosan-poly(butylene succinate) blends". Biomacromolecules 9 4 (2008): 1139-1145. http://www.scopus.com/inward/record.url?eid=2-s2.0-43149094168&partnerID=MN8TOARS.
    10.1021/bm701268s
  74. Silva, S.S.; Luna, S.M.; Gomes, M.E.; Benesch, J.; Pashkuleva, I.; Mano, J.F.; Reis, R.L.. "Plasma surface modification of chitosan membranes: Characterization and preliminary cell response studies". Macromolecular Bioscience 8 6 (2008): 568-576. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949117580&partnerID=MN8TOARS.
    10.1002/mabi.200700264
  75. Correlo, V.M.; Pinho, E.D.; Pashkuleva, I.; Bhattacharya, M.; Neves, N.M.; Reis, R.L.. "Water absorption and degradation characteristics of chitosan-based polyesters and hydroxyapatite composites". Macromolecular Bioscience 7 3 (2007): 354-363. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447344261&partnerID=MN8TOARS.
    10.1002/mabi.200600233
  76. López-Pérez, P.M.; Marques, A.P.; Silva, R.M.P.D.; Pashkuleva, I.; Reis, R.L.. "Effect of chitosan membrane surface modification via plasma induced polymerization on the adhesion of osteoblast-like cells". Journal of Materials Chemistry 17 38 (2007): 4064-4071. http://www.scopus.com/inward/record.url?eid=2-s2.0-34748835189&partnerID=MN8TOARS.
    10.1039/b707326g
  77. Pashkuleva, I.; Marques, A.P.; Vaz, F.; Reis, R.L.. "Surface modification of starch based blends using potassium permanganate-nitric acid system and its effect on the adhesion and proliferation of osteoblast-like cells". Journal of Materials Science: Materials in Medicine 16 1 (2005): 81-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-16444385371&partnerID=MN8TOARS.
    10.1007/s10856-005-6450-4
  78. Ivanova, D.; Vassileva, M.; Vassileva, N.; Pashkuleva, I.; Koleva, R.. "Stereoselective synthesis of new coumarin and N-methylcarbazole retinoic acid analogs". Journal of the Indian Chemical Society 80 6 (2003): 650-653. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041856525&partnerID=MN8TOARS.
  79. Dryanska, V.; Pashkuleva, I.; Angelov, V.. "A convenient synthesis of threo-4-amino-3, 4-diphenylbutanoic acid and its derivatives". Journal of Chemical Research - Part S 2 (2003): 89-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038643403&partnerID=MN8TOARS.
  80. Vassileva, E.; Apostolov, A.A.; Evstatiev, M.; Pashkuleva, I.; Friedrich, K.. "Effect of processing conditions on mechanical properties of pretreated gelatin samples". International Journal of Polymeric Materials and Polymeric Biomaterials 51 1-2 (2002): 103-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746332632&partnerID=MN8TOARS.
    10.1080/00914030213027
  81. Dryanska, V.; Pashkuleva, I.; Simova, S.; Angelova, S.. "Synthesis and stereochemistry of 1,2,4,5-tetraarylimidazolidines". Journal of Chemical Research - Part S 11 (2001): 457-459. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035684331&partnerID=MN8TOARS.
  82. Pashkuleva, I.; Dryanska, V.; Angelova, S.; Simova, S.. "Phase-transfer catalysed reactions of mono- and disubstituted N- (benzylidene)-benzylamines with cinnamic acid derivatives". Journal of Chemical Research - Part S 3 (2000): 103-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034023945&partnerID=MN8TOARS.
  83. Dryanska, V.; Pashkuleva, I.. "A simple and efficient synthesis of ¿-aminobutyric acid (GABA) derivatives". Organic Preparations and Procedures International 31 2 (1999): 232-236. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033243528&partnerID=MN8TOARS.
    10.1080/00304949909355722
  84. Dryanska, V.; Pashkuleva, I.; Tasheva, D.. "Preparation of ethyl esters of protected 3-aryl-2,3-diaminopropanoic acids by reaction of ethyl N-(diphenylmethylene)glycinate and azomethines". Synthetic Communications 27 11 (1997): 1849-1856. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031008215&partnerID=MN8TOARS.
    10.1080/00397919708006785
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023/09 - Current Development of 3D in vitro models of glioblastoma
Co-supervisor
Universidade do Minho, Portugal
2023/09 - Current Influence of micro and nanoplastics on blood cells
Co-supervisor
Universidade do Minho, Portugal
2023/01 - Current Layer-by-layer therapeutic constructs for the treatment of breast cancer
Co-supervisor
Biomedical Engineering (Master)
Universidade do Minho, Portugal
2020/01 - Current Bioadhesive materials for spinal cord regeneration
Co-supervisor
Universidade do Minho, Portugal
2021/11 - 2023/12 Bioadhesive hydrogels based on hyaluronic acid for spinal cord regeneration
Co-supervisor
Biomedical Engineering (Master)
Universidade do Minho, Portugal
2016 - 2023/10 Block copolymer nanopatterns for biomedical applications
Supervisor
Tissue engineering, regenerative medicine and stem cells (PhD)
Universidade do Minho, Portugal
2021/11 - 2023/01 Inorganic-templated and polymeric layer-by-layer nanocapsules for the treatment of cancer
Co-supervisor
Biomedical Engineering (Master)
2017 - 2022/07 NANOGLYCAN: Glycotools for elucidating molecular and cellular interaction of glycans in vitro
Supervisor
Universidade do Minho, Portugal
2015 - 2020 Synthesis of carbohydrate based supramolecular hydrogels for tissue engineering
Supervisor
Universidade do Minho, Portugal
2014 - 2018 Development and characterisation of hybrid polyelectrolyte fibers
Supervisor
Universidade do Minho, Portugal
2008 - 2012 Multifunctional biopolymer-based materials for modulating the activities of chronic wound enzymes
Co-supervisor
Universitat Politècnica de Catalunya, Spain
2005 - 2010 Some hints on using surface phenomena for the design and performance optimisation of distinct biomedical devices
Supervisor
Universidade do Minho, Portugal
1999 - 2001 A convenient synthesis of threo-4-amino-3,4-diphenylbutanoic acid and its derivatives
Co-supervisor
Sofiski universitet Sveti Kliment Ohridski, Bulgaria

Event organisation

Event name
Type of event (Role)
Institution / Organization
2023/09/04 - 2023/09/08 33rd Annual Conference of the European Society for Biomaterials (ESB 2023) (2023/09/04 - 2023/09/08)
Conference (Member of the Organising Committee)
2014/01 - 2014/10 Top-down fabrication and nanocharacterisation techniques to develop nanosystems for biomedical applications, 2nd Workshop within EU POLARIS project (2014/10/20 - 2014/10/22)
Workshop (Member of the Organising Committee)
2013/01 - 2013/10 Nanosystems for Medicine: Fundamentals, synthesis and applications, 1st Workshop under EU POLARIS project (2013/10/07 - 2013/10/09)
Workshop (Member of the Organising Committee)
2009/01 - 2009/05 ESBP 2009 - 5th European Symposium on Biopolymers “Design, Production & Applications of Biopolymers in Tissue Engineering, Regenerative Medicine, Drug Delivery, Biotechnology and Nanomedicine (2009/05/09 - 2009/05/12)
Symposium (Member of the Organising Committee)
2007/06 - 2008/06 TERMIS 2008 - The European Chapter of Tissue Engineering and Regenerative Medicine International Society Meeting (2008/06/22 - 2008/06/26)
Conference (Member of the Organising Committee)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2023/03/19 - 2023/03/24 Invited talk: Enhancing the selectivity and functionality of supramolecular biomaterials by glycan incorporation, Aveiro, Portugal
Conference
SupraLife first school on functional supramolecular polymeric biomaterials
Universidade de Aveiro, Portugal
2023/03/07 - 2023/03/07 Invited talk: Supramolecular chemistry and carbohydrates for targeted cancer therapies, Sofia, Bulgaria
Other
EXTREME: Excellence in colloid and interface research & innovations for better quality of life
Sofiski universitet Sveti Kliment Ohridski, Bulgaria
2023/01/16 - 2023/01/18 Plenary lecture: Hyaluronan-based materials for understanding and targeting breast cancer associated CD44 and RHAMM receptors, Lisbon, Portugal
Conference
14th Meeting of the Glycosides group GLUPOR
Universidade Nova de Lisboa, Portugal
2021/06 - 2021/06 Invited talk: Perturbation of hyaluronan functions toward understanding and treatment of breast cancer, Braga, Portugal
Conference
3th Forecast Workshop on Hallmarks in cancer and the development of diagnostic tools
2020/01 - 2020/01 Invited talk: Design of glycome-inspired bioinstructive materials, Perugia, Italy
Workshop
Winter School on Biotechnology
Università degli Studi di Perugia, Italy
2019/12 - 2019/12 Invited talk: Carbohydrate nanotools for selective inhibition of cancer metabolism, Braga, Portugal
Symposium
First symposium in Biophysics and Bionanosystems
Universidade do Minho, Portugal
2018/08 - 2018/08 Invited talk: Glycans as multifunctional building blocks for biomaterials, NY, USA
Seminar
Seminar series of the Nanoscience initiative at the Advanced Science Research Center
City University of New York, United States
2018/07 - 2018/07 Invited talk: Exploring glycan-protein interactions in biomaterials design, Lisbon, Portugal
Meeting
Bioscience Analysis Tools Meeting, Lisbon, Portugal
2017/09 - 2017/09 Invited talk: Engineering supramolecular functional biomaterials from glycans, Aveiro, Portugal
Meeting
12th Meeting of the Glycosides group GLUPOR
2017/05 - 2017/05 Invited talk: Supramolecular glyco-approaches for biomedical applications, Porto, Portugal MSc programme on “Biointerfaces and Cell Behaviour”
Universidade Católica Portuguesa Centro Regional do Porto, Portugal
2016/11 - 2016/11 Invited talk: Sulfated glycosaminoglycans: biosynthesis, bioactivities and associated diseases, Guimaraes, Portugal
Workshop
Chem2Nature first School on “Chemical Strategies for the modification of natural origin materials for biomedical applications”
2016/05 - 2016/05 Invited talk: Glycan building blocks for supramolecular biomaterials, Braga, Portugal
Seminar
Ciência Falada
Universidade do Minho, Portugal
2016/04 - 2016/04 Invited talk: Supramolecular nanobioparticles from glycosaminoglycans: designs, synthesis and characterization, Lisbon, Portugal
Workshop
Trends in Nanobioparticles Characterization
2013/07 - 2013/07 Invited talk: Sweet talk on some glyco-approaches for biochemical applications, Stuttgart, Germany
Seminar
Max-Planck-Institut für Intelligente Systeme Physical Intelligence Department, Germany

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2024/01 Molecular imprinting technologies for growth factor sequestration and control of stem cell fate in tendon regeneration
(Thesis) Arguer
Simão Pedro Barbosa Teixeira (PhD)
Universidade do Minho, Portugal
2023/10 Block Copolymer Nanopatterns for Biomedical Applications
Supervisor
Raúl Fontelo Rodríguez (PhD)
Universidade do Minho, Portugal
2023/06 Glycotools for elucidating molecular and cellular interactions of glycans in vitro
Supervisor
Ana Margarida de Moura Pereira e Ferreira Carvalho (PhD)
Universidade do Minho, Portugal
2022/03/10 Nanomaterials for controlling bacterial pathogens and resistance occurrence
President of the jury
Aleksandra Ivanova (PhD)
Universitat Politècnica de Catalunya, Spain
2021/04/13 Gellan-gum based hydrogels for tissue engineering applications
(Thesis) Arguer
Sílvia Cristina Araújo Vieira (PhD)
Universidade do Minho, Portugal
2020/12 Strategies towards the recreation of a hair follicle regenerative microenvironment
(Thesis) Arguer
Carla Patricia Martins Abreu (PhD)
Universidade do Minho, Portugal
2020/07 Fucoidan-based strategies envisioning antitumor therapies
(Thesis) Arguer
Ana Catarina Freitas Salazar de Oliveira (PhD)
Universidade do Minho, Portugal
2020/07 Supramolecular assembly of carbohydrate amphiphiles for biomedical applications
Supervisor
Alexandra Manuela Fernandes Brito (PhD)
Universidade do Minho, Portugal
2020/07 Micro/nano-structured hydrogels based on platelet lysate for tissue engineering and regeneration
(Thesis) Arguer
Bárbara Bruna da Silva Mendes (PhD)
Universidade do Minho, Portugal
2019/10 Uncovering heparan sulfate proteoglycans biosynthetic pathways and functional relevance in gastric cancer
(Thesis) Main arguer
Catarina Marques Goncalves (Master)
Universidade do Porto, Portugal
2019/03 Biomimetic functionalisation of hierarchical scaffolds for tendon tissue engineering
(Thesis) Main arguer
Helena Maria Coelho de Almeida (Master)
Universidade do Minho, Portugal
2018/03 Tailoring Injectable hyaluronic acid/cellulose nanocrystal hydrogels for soft tissue regeneration
(Thesis) Main arguer
Cristiana Filipa Ribeiro e Silva (Master)
Universidade do Minho, Portugal
2015 Exploring hyaluronic acid enriched with platelet lysates as a promising injectable and cryostable hydrogel for regenerative medicine applications
(Thesis) Main arguer
Lisete dos Santos Neves (Master)
Universidade do Minho, Portugal
2014/11 Graphene nanoribbons for multilayer films based on natural polymers
(Thesis) Main arguer
Helena Cristina Lopes Rocha (Master)
Universidade do Minho, Portugal
2014 Novel 3D scaffolds modified with nanostructured polymeric coatings or micro/nanofibers for tissue engineering applications
(Thesis) Arguer
Sara Maria Marques de Oliveira (PhD)
Universidade do Minho, Portugal
2013/12 Bioactive membranes for bone regeneration
(Thesis) Arguer
Sofia Gloria Ferreira Caridade (PhD)
Universidade do Minho, Portugal
2013/12 Immobilization of specific growth factors from platelet lysate at the surface of electrospun nanofibers for tissue engineering applications
(Thesis) Main arguer
Ana Catarina Freitas Salazar de Oliveira (Master)
Universidade do Minho, Portugal
2012/12 Development of multifunctional biopolymeric materials for treatment of decubitus ulcers
(Thesis) Main arguer
Guillem Rocasalbas Lozano (PhD)
Universitat Politècnica de Catalunya, Spain
2012/12 Multifunctional biopolymer-based materials for modulating the activities of chronic wound enzymes
(Thesis) Main arguer
Antonio Francesko (PhD)
Universitat Politècnica de Catalunya, Spain
2011/12 Cells behavior on superhydrophobic surfaces with different topographies
(Thesis) Main arguer
Bianca Lourenço (Master)
Universidade do Minho, Portugal
2011/12 Biotechnical and biomimetic approaches for coating of textile surfaces and enhancement of cleaning formulation
(Thesis) Main arguer
Carlos Diaz Blanco (PhD)
Universitat Politècnica de Catalunya, Spain
2010/11 Patterned superhydrophobic surfaces as a new platform for high-throughput evaluation of biomaterials interactions with proteins and cells
(Thesis) Main arguer
Ana Isabel Morais Neto (Master)
Universidade do Minho, Portugal
2010/01 Some hints on using surface phenomena for the design and performance optimization of distinct biomedical devices
Supervisor
Paula Matilde López Pérez (PhD)
Universidade do Minho, Portugal

Association member

Society Organization name Role
2010/01 - Current Associação Nacional de Investigadores em Ciência e Tecnologia Founding member
2010 - Current Royal Society of Chemistry
2010 - Current American Chemical Society

Committee member

Activity description
Role
Institution / Organization
2018 - Current General Council of I3Bs, University of Minho
Member
Universidade do Minho, Portugal
2018 - 2023 Scientific Council of I3Bs, University of Minho
Member
Universidade do Minho, Portugal
2020/09 - 2022/08 Steering Committee of the Doctoral Program in Tissue Engineering, Regenerative Medicine and Stem Cells
Member
2017 - 2018 General Council of Department of Polymer Engineering, University of Minho, Portugal
Member
Universidade do Minho, Portugal
2012 - 2015 General Council of Department of Polymer Engineering, University of Minho, Portugal
Member
Universidade do Minho, Portugal

Conference scientific committee

Conference name Conference host
2016/04 - Current 5th Portuguese Young Chemists Meeting (5th PYCheM)
2023/09/04 - 2023/09/08 ESB2023: 33rd Annual Conference of the European Society for Biomaterials Davos, Switzerland
2023/01/16 - 2023/01/18 GLUPOR 14: 14th International Meeting of the Portuguese Carbohydrate Group NOVA School of Science and Technology, NOVA University of Lisbon, Caparica, Portugal
2019/09/03 - 2019/09/05 GLUPOR 13: 13th International Meeting of the Portuguese Carbohydrate Group Universidade do Porto

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2015 - Current Biomaterials module of the Doctoral Programme in Tissue Engineering and Regenerative Medicine (TERM) (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Minho, Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2023 - Current AXA Research Fund
Evaluator
2022 - Current Czech Scientific Foundation
Evaluator
2021 - Current Horizon Marie Sklodowska-Curie actions, Chemistry Panel: Evaluation of individual fellowships
Evaluator
2020 - Current H2020 FET OPEN
Evaluator
2015 - 2024 Swiss National Science Foundation: Evaluation of Individual fellowships
Evaluator
Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung, Switzerland Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
2018 - 2020 ERA-NET: evaluations of proposals
Evaluator
European Union
2015 - 2020 H2020 Marie Sklodowska-Curie actions, Chemistry Panel: Evaluation of individual fellowships
Evaluator
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
2015 - 2016 EMPA, Switzerland (co-fund programme): evaluation of individual fellowships
Evaluator
Empa Materials Science and Technology, Switzerland Empa Materials Science and Technology

Journal scientific committee

Journal title (ISSN) Publisher
2021 - Current Cells (2073-4409) MDPI
2019 - Current Molecules (1420-3049) MDPI AG
2016 - Current Carbohydrate Polymers (0144-8617) Elsevier
2011 - Current Journal of Tissue Engineering and Regenerative Medicine (1932-7005) Wiley (John Wiley & Sons)

Mentoring / Tutoring

Topic Student name
2023 - Current Supramolecular materials targeting cancer Alexandra Brito
2019 - Current Tackling Tumor Heterogeneity Using Biomaterial-Based Multifunctional Nanocarriers Against Cancer Rui Costa
2019 - Current Influence of the GAGs molecular weight and sulfation degree on cells behaviour Diana Soares da Costa
2018/11 - 2019/03 Combined layer by layer/liposome devices for sustained drug release Vicente Domínguez Arca
2016 - 2019 Self-healing hydrogels based on glycosaminoglycans Rui Costa
2009 - 2019 Influence of the GAGs molecular weight and sulfation degree on stem cells cytoskeleton organisation Diana Soares da Costa
2018/03 - 2018/11 Effect of stereochemistry on the assembly and properties of supramolecular structures made of short aromatic carbohydrate amphiphiles YuTing Gao
2018/01 - 2018/05 Bioactivity of hydroxyapatite nanorods Ramon Rial Silva
2013 - 2018 Novel star and brush polysaccharide architectures as protein nanocarriers Ramon Novoa-Carballal
2015 - 2017 Combining aloe compounds with natural polymers at micro/nano scale for cancer treatment Simone Silva
2014 - 2015 Sulfatases as tools in the design and synthesis of glycan biomaterials Klaus Neumuller
2014 - 2015 Synthesis of glycan amphiphiles as hydrogelators Raquel Teixeira
2013 - 2014 Sulfated polysaccharides as 3D matrixes for cell encapsulation Rami Mhanna
2011 - 2013 Synthesis and characterisation of sugar decoys for metabolic glycoengineering Nevena Petkova
2010 - 2011 Understanding GAG molecular interactions using different spatial environments (homogeneous and nano-structured surfaces) Patricia Lisboa