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PAULO JOSÉ DE AZEREDO FALCÃO DE FREITAS TAVARES. Concluiu o(a) Licenciatura em Medicina em 1985 pelo(a) Universidade de Coimbra Faculdade de Medicina. É Assistente graduado no(a) Hospitais da Universidade de Coimbra. Publicou 41 artigos em revistas especializadas. Possui 1 livro(s). Organizou 3 evento(s). Orientou 1 dissertação(ões) de mestrado. Recebeu 1 prémio(s) e/ou homenagens. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Chronic myeloid leukemia; Gene expression profiling; Immune monitoring; Immunotherapy; Interferon; Osteosarcoma; Survival; Tumor markers; Tumor microenvironment; Tumor-infiltrating lymphocytes; .
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Identification

Personal identification

Full name
PAULO JOSÉ DE AZEREDO FALCÃO DE FREITAS TAVARES

Citation names

  • TAVARES, PAULO
  • Freitas-Tavares, Paulo
  • Tavares, P
  • Freitas-Tavares. P

Author identifiers

Ciência ID
A810-2893-DC64
ORCID iD
0000-0001-7832-4134
Google Scholar ID
https://scholar.google.com/citations?hl=en&user=UjJtjKgAAAAJ
Researcher Id
V-8584-2019
Scopus Author Id
20936340000
Education
Degree Classification
1999/05
Concluded
 Consultor em Hematologia Clínica (Outros)
Ministério da Saúde, Portugal
1997/03
Concluded
 Especialista em Oncologia Médica (Título de especialista)
Major in Oncologia Médica
Ordem dos Médicos, Portugal
1988/01/01 - 1993/01/04
Concluded
 Assistente Hospitalar de Hematologia (Título de especialista)
Major in Hematologia Clínica
Ordem dos Médicos, Portugal

Ministério da Saúde, Portugal
18.3
1990/11/06 - 1990/11/06
Concluded
 Provas de Capacidade Científica e Aptidão Pedagógica (Outros)
Major in Hematologia
Universidade de Coimbra Faculdade de Medicina, Portugal
 Aprovado
1988/07/29
Concluded
 Climatologia e Hidrologia (Especialização pós-licenciatura)
Universidade de Coimbra Faculdade de Medicina, Portugal
1979 - 1985
Concluded
 Medicina (Licenciatura)
Universidade de Coimbra Faculdade de Medicina, Portugal
 17
1979/07
Concluded
 Ano Propedêutico (Ensino secundário)
Ministério da Educação, Portugal
1976/10 - 1978/07
Concluded
 Curso Complementar dos Liceus (Ensino secundário)
Escola Secundária José Falcão, Portugal
 18
1973/10 - 1976/07
Concluded
 Curso Geral dos Liceus (Ensino básico 3º ciclo)
Escola Secundária José Falcão, Portugal
1971/10 - 1973/07
Concluded
 Ciclo Preparatório (Ensino básico 2º ciclo)
Escola Martim de Freitas, Portugal
1971/07
Concluded
 Diploma da 4ª classe (Ensino básico 1º ciclo)
Escola Primária dos Olivais, Portugal
 19
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
1990/11 - 1998/11 Assistant (University Teacher) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
1988/02 - 1990/11 Trainee Assistant (University Teacher) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
1985/02/04 - 1988/02/24 Tutor (University Teacher) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal

Other Careers

Category
Host institution 		Employer
1999 - Current Assistente graduado (Médica) Hospitais da Universidade de Coimbra, Portugal
1993/01 - 1999 Assistente (Médica) Hospitais da Universidade de Coimbra, Portugal
Hospitais da Universidade de Coimbra, Portugal
1988/01 - 1993/01 Interno (Médica) Hospitais da Universidade de Coimbra, Portugal
Hospitais da Universidade de Coimbra, Portugal
1986/01 - 1987/09 Interno (Médica) Administração Regional de Saúde do Centro IP, Portugal
Hospitais da Universidade de Coimbra, Portugal

Positions / Appointments

Category
Host institution 		Employer
1990 - 1998 Manager of Laboratory, Institute, Museum, Centre or Observatory Universidade de Coimbra Instituto de Anatomia Patológica, Portugal
Laboratório de Hematologia, Portugal
Outputs

Publications

Book
  1. Freitas-Tavares, Paulo. Leucemia mieloide crónica. 1990.
Journal article
  1. José Manuel Casanova; Jani-Sofia Almeida; John David Reith; Luana Madalena Sousa; Ruben Fonseca; Paulo Freitas-Tavares; Manuel Santos-Rosa; Paulo Rodrigues-Santos. "Tumor-Infiltrating Lymphocytes and Cancer Markers in Osteosarcoma: Influence on Patient Survival". Cancers (2021): https://doi.org/10.3390/cancers13236075.
    10.3390/cancers13236075
  2. Luana Madalena Sousa; Jani Sofia Almeida; Tânia Fortes-Andrade; Manuel Santos-Rosa; Paulo Tavares; José Casanova; Paulo Rodrigues-Santos. "Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy". Cancers (2021): https://www.mdpi.com/2072-6694/13/15/3885.
    10.3390/cancers13153885
  3. Tânia Fortes-Andrade; Jani Sofia Almeida; Luana Madalena Sousa; Manuel Santos-Rosa; Paulo Tavares; José Manuel Casanova; Paulo Rodrigues-Santos. "The Role of Natural Killer Cells in Soft Tissue Sarcoma: Prospects for Immunotherapy". Cancers (2021): https://www.mdpi.com/2072-6694/13/15/3865.
    10.3390/cancers13153865
  4. Casanova, José Manuel; Almeida, Jani-Sofia; Reith, John David; Sousa, Luana Madalena; Fonseca, Rúben; Freitas-Tavares, Paulo; Santos-Rosa, Manuel; Rodrigues-Santos, Paulo. "Tumor-Infiltrating Lymphocytes and Cancer Markers in Osteosarcoma: Influence on Patient Survival". (2021): http://hdl.handle.net/10316/96612.
  5. Freitas-Tavares, Paulo. "Long-Term Response after 94 Cycles of Trabectedin in a Patient with Metastatic Leiomyosarcoma of the Lower Extremity". Case Reports in Oncology (2020): http://dx.doi.org/10.1159/000505393.
    10.1159/000505393
  6. Alves R; McArdle SEB; Vadakekolathu J; Gonçalves AC; Freitas-Tavares P; Pereira A; Almeida AM; Sarmento-Ribeiro AB; Rutella S. "Flow cytometry and targeted immune transcriptomics identify distinct profiles in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors with or without interferon-a.". Journal of translational medicine (2020): http://europepmc.org/abstract/med/31900171.
    10.1186/s12967-019-02194-x
  7. Alves, Raquel; McArdle, Stephanie E. B.; Vadakekolathu, Jayakumar; Gonçalves, Ana Cristina; Freitas-Tavares, Paulo; Pereira, Amélia; Almeida, Antonio M.; Sarmento-Ribeiro, Ana Bela; Rutella, Sergio. "Flow cytometry and targeted immune transcriptomics identify distinct profiles in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors with or without interferon-a". (2020): http://hdl.handle.net/10400.14/32300.
    10.1186/s12967-019-02194-x
  8. Almeida JS; Couceiro P; López-Sejas N; Alves V; Ružicková L; Tarazona R; Solana R; et al. "NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors.". Frontiers in immunology (2019): http://europepmc.org/abstract/med/31695700.
    10.3389/fimmu.2019.02493
  9. Alves R; Gonçalves AC; Jorge J; Marques G; Luís D; Ribeiro AB; Freitas-Tavares P; et al. "MicroRNA signature refine response prediction in CML.". Scientific reports (2019): http://europepmc.org/abstract/med/31273251.
    10.1038/s41598-019-46132-9
  10. Alves R; Gonçalves AC; Jorge J; Alves J; Alves da Silva A; Freitas-Tavares P; Nascimento Costa JM; Almeida AM; Sarmento-Ribeiro AB. "Everolimus in combination with Imatinib overcomes resistance in Chronic myeloid leukaemia.". Medical oncology (Northwood, London, England) (2019): http://europepmc.org/abstract/med/30796703.
    10.1007/s12032-019-1253-5
  11. Alves, Raquel; Goncalves, Ana Cristina; Jorge, Joana; Marques, Gilberto; Ribeiro, Andre Barbosa; Tenreiro, Rita; Coucelo, Margarida; et al. "Genetic variability of influx and efflux transporters: the impact on susceptibility to chronic myeloid leukemia development". European Journal of Clinical Investigation (2019): https://publons.com/publon/21142750/.
  12. "INFLUX/EFFLUX TRANSPORTERS IN CHRONIC MYELOID LEUKEMIA: THE INFLUENCE OF GENETIC VARIANTS ON SUSCEPTIBILITY AND DRUG RESPONSE: PS1170". HemaSphere 3 (2019): 532-532.
    10.1097/01.HS9.0000562964.05114.68
  13. Rodrigues-Santos, Paulo; Couceiro, Patricia; Oliveira, Sonia; Almeida, Jani Sofia; Alves, Vera; Ruzickova, Lenka; Freitas-Tavares, Paulo; Santos-Rosa, Manuel. "KILLER-CELL IMMUNOGLOBULIN-LIKE RECEPTORS ASSOCIATED WITH SUSCEPTIBILITY AND MOLECULAR RESPONSE TO TYROSINE KINASE INHIBITOR THERAPY IN CHRONIC MYELOID LEUKEMIA". HLA (2019): https://publons.com/publon/21665916/.
  14. "IMMUNE SYSTEM AND CHRONIC MYELOID LEUKEMIA: THE IMPACT OF TYROSINE KINASE INHIBITORS: PF401". HemaSphere 3 (2019): 152-153.
    10.1097/01.HS9.0000559816.89558.95
  15. Alves, Raquel; Gonçalves, Ana Cristina; Jorge, Joana; Marques, Gilberto; Luís, Dino; Ribeiro, André B.; Freitas-Tavares, Paulo; et al. "MicroRNA signature refine response prediction in CML". (2019): http://hdl.handle.net/10400.14/32503.
    10.1038/s41598-019-46132-9
  16. Rodrigues-Santos P; López-Sejas N; Almeida JS; Ruzicková L; Couceiro P; Alves V; Campos C; et al. "Effect of Age on NK Cell Compartment in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors.". Frontiers in Immunology (2018): http://europepmc.org/abstract/med/30487792.
    10.3389/fimmu.2018.02587
  17. Loureiro da Silva AJ; Carvalho C; Jacobetty M; Freitas J; Fonseca R; Tavares PF; Garcia H; Borrego M; Casanova JM. "Neoadjuvant Trabectedin plus Radiotherapy in High-Grade Sarcoma of the Leg: A Case Report.". Case reports in oncology (2018): http://europepmc.org/abstract/med/30140213.
    10.1159/000490849
  18. Alves, R.; Goncalves, A. C.; Couceiro, P.; Rodrigues-Santos, P.; Freitas-Tavares, P.; Ribeiro, L.; Almeida, A. M.; Sarmento-Ribeiro, A. B.. "THE ROLE OF MICRORNAS IN CHRONIC MYELOID LEUKEMIA THERAPEUTIC SELECTION". Haematologica (2017): https://publons.com/publon/9003993/.
  19. Rodrigues-Santos, P.; Almeida, J. S.; Couceiro, P.; Alves, V.; Simplicio, J. R.; Ruzickova, L.; Freitas-Tavares, P.; Santos-Rosa, M.. "SOLUBLE AND MEMBRANE-BOUND RECEPTOR-LIGAND IMMUNE CHECKPOINTS AND CHRONIC MYELOID LEUKEMIA: CORRELATIONS WITH MOLECULAR RESPONSE AND TYROSINE KINASE INHIBITOR THERAPY". Haematologica (2017): https://publons.com/publon/19057177/.
  20. Rodrigues Santos, P.; Abranches, P.; Couceiro, P.; Simplicio, J. R.; Almeida, J. S.; Alves, V.; Ruzickova, L.; Freitas-Tavares, P.; Santos-Rosa, M.. "TRANSCRIBED ULTRACONSERVED NONCODING RNAS (T-UCRS) IN CHRONIC MYELOID LEUKEMIA: EXPRESSION PROFILES ASSOCIATED WITH MOLECULAR RESPONSE TO THERAPY WITH TYROSINE KINASE INHIBITORS". Haematologica (2017): https://publons.com/publon/19057181/.
  21. Alves, R. S.; Goncalves, A. C.; Couceiro, P.; Rodrigues-Santos, P.; Freitas-Tavares, P.; Ribeiro, L.; Almeida, A.; Sarmento-Ribeiro, A. B.. "MTOR INHIBITION IN CML: A NEW THERAPEUTIC OPTION". Haematologica (2016): https://publons.com/publon/9004007/.
  22. Goncalves, A. C.; Alves, R.; Couceiro, P.; Rodrigues-Santos, P.; Freitas-Tavares, P.; Pereira, A.; Ribeiro, L.; et al. "GENETIC VARIABILITY OF OXIDATIVE STRESS AND DNA REPAIR GENES POTENTIAL PROGNOSTIC AND THERAPEUTIC BIOMARKERS IN CHRONIC MYELOID LEUKEMIA". Haematologica (2016): https://publons.com/publon/9003999/.
  23. Rodrigues Santos, P.; Almeida, J.; Couceiro, P.; Alves, V.; Ruzickova, L.; Freitas-Tavares, P.; Santos-Rosa, M.. "LEUKEMIC STEM CELLS DEFINED BY DIPEPTIDIL-PEPTIDASE IV (CD26) EXPRESSION IN CD34+CD38-STEM CELLS AND TYROSINE KINASE INHIBITOR THERAPY IN CHRONIC MYELOID LEUKEMIA". Haematologica (2016): https://publons.com/publon/19057183/.
  24. Rodrigues Santos, P.; Almeida, J.; Couceiro, P.; Alves, V.; Ruzickova, L.; Freitas-Tavares, P.; Santos-Rosa, M.. "PROGRAMMED CELL DEATH PROTEIN 1 (PD-1) DOWNREGULATION ON REGULATORY T CELLS DURING TYROSINE KINASE INHIBITOR THERAPY IN CHRONIC MYELOID LEUKEMIA". Haematologica (2016): https://publons.com/publon/19057179/.
  25. Santos, P. Rodrigues; Couceiro, P.; Coirada, F.; Almeida, J.; Queiros, D.; Gomes-Silva, D.; Alves, V.; et al. "TYROSINE KINASE INHIBITOR THERAPY INDUCES ALTERATIONS OF CD137 AND CD137L EXPRESSION IN CHRONIC MYELOID LEUKEMIA PATIENTS". Haematologica (2015): https://publons.com/publon/21665917/.
  26. Rodrigues Santos, P.; Couceiro, P.; Almeida, J.; Diniz, A.; Alves, V.; Ruzickova, L.; Freitas-Tavares, P.; Santos-Rosa, M.. "IMMUNE MONITORING OF THERAPEUTIC EFFICACY IN CHRONIC MYELOID LEUKEMIA". Haematologica (2015): https://publons.com/publon/19057185/.
  27. Rodrigues Santos, P.; Couceiro, P.; Almeida, J.; Queiros, D.; Gomes-Silva, D.; Alves, V.; Ruzickova, L.; Freitas-Tavares, P.; Santos-Rosa, M.. "DYNAMIC EXPANSION AND FUNCTIONAL TUNING OF NATURAL KILLER CELLS IN CHRONIC MYELOID LEUKEMIA". Haematologica (2015): https://publons.com/publon/19057184/.
  28. Goncalves, A. C.; Alves, R.; Cortesao, E.; Freitas-Tavares, P.; Carda, J. P.; Rito, L.; Couceiro, P.; et al. "POLYMORPHISMS OF DNMTS AND FOLATE/METHIONINE METABOLISM GENES INFLUENCE DNA METHYLATION, GENETIC SUSCEPTIBILITY AND PROGNOSIS OF MYELOID NEOPLASIA PATIENTS". Haematologica (2015): https://publons.com/publon/9003996/.
  29. Ruzickova, L.; Freitas Tavares, P.; Santos, P. Rodrigues; Couceiro, P.; Ribeiro, L.. "IMATINIB TREATMENT DURATION EFFECT ON ESTIMATED GLOMERULAR FILTRATION RATE IN CHRONIC MYELOID LEUKEMIA PATIENTS". Haematologica (2015): https://publons.com/publon/34739508/.
  30. Goncalves, A. C.; Alves, R.; Cortesao, E.; Freitas-Tavares, P.; Carda, J. P.; Espadana, A. I.; Magalhaes, E.; et al. "PREDISPOSITION TO MYELOID NEOPLASIAS - THE ROLE OF OXIDATIVE STRESS GENES POLYMORPHISMS". Haematologica (2014): https://publons.com/publon/9004005/.
  31. Azevedo CP; Casanova JM; Guerra MG; Santos AL; Portela MI; Tavares PF. "Tumors of the foot and ankle: a single-institution experience.". (2013): http://europepmc.org/abstract/med/23333280.
    10.1053/j.jfas.2012.12.004
  32. Silva, D.; Couceiro, P.; Ferreira-Teixeira, M.; Freitas-Tavares, P.; Santos, P.. "IL-2, IL-12 AND IL-15 PREVENT REACTIVE OXYGEN SPECIES ACCUMULATION ON NATURAL KILLER CELLS FROM CHRONIC MYELOID LEUKEMIA PATIENTS FOLLOWING INTERFERON-ALPHA, IMATINIB AND DASATINIB THERAPY". Haematologica (2013): https://publons.com/publon/21665918/.
  33. "Can Polymorphisms In Oxidative Stress Related Genes Be a Risk Factor For CML?". Blood 122 21 (2013): 5156-5156.
    10.1182/blood.V122.21.5156.5156
  34. "ABC Expression As Additionally Marker To Monitoring Response In CML-A Preliminary Study". Blood 122 21 (2013): 5183-5183.
    10.1182/blood.V122.21.5183.5183
  35. Couceiro, P.; Soverini, S.; Ferreira-Teixeira, M.; Freitas-Tavares, P.; Santos, P.. "CREENING OF ABL KINASE DOMAIN MUTATIONS USING NEXT GENERATION SEQUENCING IN CHRONIC MYELOID LEUKAEMIA: IMPACT IN THE RESPONSE TO TREATMENT WITH TYROSINE KINASE INHIBITORS". Haematologica (2013): https://publons.com/publon/21665919/.
  36. Ana Paula Carrondo; António Melo Gouveia; Clementina Varela; Daniel Pereira Da Silva; Florbela Braga; Isabel Fernandes; João Oliveira; et al. "ABORDAGEM TERAPÊUTICA EM SARCOMAS". Revista Portuguesa de Farmacoterapia (2012):
    10.25756/rpf.v4i1.77
  37. Azevedo CPC; Tavares PJA; Portela MIP; Santos AJL; Casanova JMP. "Primary bone lymphoma.". (2010): http://europepmc.org/abstract/PMC/PMC3255069.
  38. Torres F; Ivanova-Dragoeva A; Pereira M; Veiga J; Rodrigues AS; Sousa AB; Tavares P; Fernandes AR. "An e6a2 BCR-ABL fusion transcript in a CML patient having an iliac chloroma at initial presentation.". (2007): http://europepmc.org/abstract/med/17487751.
    10.1080/10428190701216402
  39. Antunes, M.; Bernardo, J.; Salete, M.; Prieto, D.; Eugénio, L.; Tavares, P.. "Excision of pulmonary metastases of osteogenic sarcoma of the limbs". European Journal of Cardio-thoracic Surgery 15 5 (1999): 592-596. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032974395&partnerID=MN8TOARS.
    10.1016/S1010-7940(99)00098-6
  40. Freitas-Tavares, Paulo. "Seminoma Primário do Mediastino". Medicina Interna 3 3 (1996): 162-165. http://revista.spmi.pt/site/revista_download.php?ficheiro=vol03_n3_1996_162-165.pdf.
  41. Freitas-Tavares, Paulo. "Primeira consulta de hematologia". Coimbra Médica 15 3 (1994): 171-175. http://eds.a.ebscohost.com/eds/detail/detail?vid=2&sid=6d72bac4-b51f-4434-a5ea-bf0d17a1a23d%40sessionmgr4007&bdata=Jmxhbmc9cHQtcHQmc2l0ZT1lZHMtbGl2ZQ%3d%3d#AN=ibu.b1639109&db=cat01014a.

Other

Other output
  1. Canábis, a Droga Medicinal. 2018. Freitas-Tavares, Paulo. https://www.rtp.pt/play/p4231/e366870/linha-da-frente.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2012 - 2013/04 Mieloma múltiplo : uma perspectiva multidisciplinar
Supervisor
 Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018/03/07 - 2018/03/09 3º Curso de Tumores do Aparelho Locomotor (2018/03/07 - 2018/03/09)
Congress (Co-organisor)
 Hospitais da Universidade de Coimbra, Portugal
2011/03/30 - 2011/04/02 2º Curso de Tumores do Aparelho Locomotor (2011/03/30 - 2011/04/02)
Congress (Co-organisor)
 Hospitais da Universidade de Coimbra, Portugal
1996/05/13 - 1996/05/17 1º Curso de Tumores do Aparelho Locomotor (1996/05/13 - 1996/05/17)
Congress (Co-organisor)
 Hospitais da Universidade de Coimbra, Portugal

Interview (tv / radio show)

Program Topic
2018/09/27 - 2018/09/27 Linha da Frente Canabis medicinal
Distinctions

Other distinction

2013 Melhor Trabalho em Síndromes Mieloproliferativos
Sociedade Portuguesa de Hematologia, Portugal