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Ana obtained her BSc (in 2008) and MSc (in 2010) from University of Porto. Then, she moved to New Haven, CT, USA to perform her PhD research at the Department of Immunobiology, at Yale University (New Haven, CT, USA). Her graduated studies focused on the positional regulation of hematopoietic progenitors and differentiating B lymphocytes in the bone marrow and were supervised by Dr. João Pedro Pereira (Yale University). This work provided groundbreaking evidence of the overlapping between hematopoietic stem cell maintenance and lymphoid differentiation niches, and is a valuable contribution to the understanding of B lymphopoiesis in vivo. In May 2016, Ana joined the Iron and Innate Immunity lab as a postdoctoral researcher, aiming to identify the molecular mechanisms leading to the development of anemia during chronic infections, as Tuberculosis and NMT. In March 2019, supported by an CEEC Individual contract (2017 call), Ana became a Junior Investigator at i3S. From February 2019 to July 2020, Ana was an Invited Professor at ICBAS, teching Microbiology and Biology of Infection courses. Ana has published 11 peer-review articles (with more than 300 citations) at high impact journals such as J. Exp. Med., Immunity, the Journal of Imunology, Haematologica, Clinical reviews in Allergy & Immunology.
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Identification

Personal identification

Full name
Ana Cordeiro Gomes

Citation names

  • Gomes, Ana Cordeiro

Author identifiers

Ciência ID
A919-63B9-1DB0
ORCID iD
0000-0001-5305-8538

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2017/09/18 - 2023/06/23
Concluded
 Medicina (Mestrado integrado)
Universidade do Porto Faculdade de Medicina, Portugal
2017/09/21 - 2020/07/05
Concluded
 Licenciatura em Ciências Básicas da Saúde (180 ECTS) (Mestrado integrado)
Universidade do Porto Faculdade de Medicina, Portugal
2016/09/30
Concluded
 FELASA category C course for Handling of Laboratory Animal (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2016
Concluded
 Doutoramento em Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Positional Regulation of B Lymphocyte Development in Bone Marrow" (THESIS/DISSERTATION)
 Aprovado com Distinção e unanimidade
2011/08/20
Concluded
 TOEFL iBT (Postgraduate Certificate)
Educational Testing Services Ewing, United States
2010
Concluded
 Mestrado em Bioquímica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Characterization of the anti-bacterial activity of the recently found iron chelator CP777 against M. avium" (THESIS/DISSERTATION)
 18
2008
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Efeito de diferentes quelantes de ferro no crescimento de M. avium" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2019/03/01 - 2023/12/31 Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/05/01 - 2019/01/31 Postdoc (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2010/10/26 - 2015/03/31 Researcher (Research) Yale University School of Medicine, United States
2010/10/26 - 2011/03/31 Research Trainee (Research) Yale University School of Medicine, United States
2009 - 2009 Research Trainee (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2019/02/11 - 2020/07/15 Invited Assistant Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Other Careers

Category
Host institution 		Employer
2024/01/01 - Current Interno (Médica) Centro Hospitalar Universitário de São João, Portugal

Others

Category
Host institution 		Employer
2024/01/01 - Current Clinical Affiliate Member Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2011/04/01 - 2015/03/31 PhD student Yale University School of Medicine, United States
Projects

Grant

Designation Funders
2022/05/01 - 2024/04/30 Bone SAAver: Identification of mechanisms and biomarkers of bone loss in patients with Cystic Fibrosis
003055G221 - Gomes
Principal investigator
Cystic Fibrosis Foundation
Ongoing
2022/03/01 - 2023/03/01 Inflammabone – Understanding how Chronic Infection disrupts the hematopoietic niche leading to osteopenia
KOG-202108-00929
Principal investigator
European Hematology Association
Ongoing

Contract

Designation Funders
2016/05/01 - 2019/01/31 “NORTE-01-0145-FEDER-000012, Structured Programme on Bioengineering Therapies for Infectious Diseases and Tissue Regeneration
NORTE2020HOST07-BPD
Post-doc Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Concluded
2014/06/15 - 2015/03/31 Cellular and molecular analysis of B lymphocyte development and selection
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES/1R01AI113040-01/US
PhD Student Fellow
Yale University School of Medicine, United States
 National Institutes of Health
Concluded
2012/09/01 - 2015/03/31 Control of B-lineage cell migration during differentiation in bone marrow
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES/1R56AI098996-01/US
PhD Student Fellow
Yale University School of Medicine, United States
 National Institutes of Health
Concluded
Outputs

Publications

Conference paper
  1. João Pedro Pereira; Vivian Lim; Gomes, Ana Cordeiro; Takahiro Hara; Dietmar Herndler-Brandstetter; Richard A Flavell; Takashi Nagasawa; Koichi Ikuta. "Hematopoietic stem cell niches control multipotent progenitor differentiation". Paper presented in IMMUNOLOGY 2016, Seattle, WA, 2016.
    Published
  2. João Pedro Pereira; Thomas Beck; Gomes, Ana Cordeiro. "Migration within chemoattractant-defined niches regulates B cell receptor signaling, lymphocyte differentiation and survival (P5087)". Paper presented in IMMUNOLOGY 2013, Honolulu, HI,, 2013.
    Published
Conference poster
  1. Gomes, Ana Cordeiro; Fonseca, Óscar; Gomes, Maria Salomé; Amorim, Maria Adelina. "Identification of biomarkers of bone loss in patients with Cystic Fibrosis". Paper presented in XLVIII Annual Meeting of the Portuguese Society for Immunology, 2023.
  2. Fonseca, Óscar; Carvalho Oliveira, Tiago; Gomes, Maria Salomé; Gomes, Ana Cordeiro. "Production of Serum Amyloid A3 protein by Mycobacterium avium-infected macrophages drives osteoporosis during infection". Paper presented in 8th edition of the Molecular and Cell Biology Symposium Lets have a moment of science!, 2022.
  3. Gomes, Ana Cordeiro. "IFN-gamma–Dependent Reduction of Erythrocyte Life Span Leadsto Anemia during Mycobacterial Infection". Paper presented in ANEMIA2020, 2020.
  4. Gomes, Ana Cordeiro; Thomas Beck; João Pedro Pereira. "MOLECULAR MECHANISMS OF DEVELOPING B CELL EGRESS FROM THE BONE MARROW.". Paper presented in Keystone Symposia on B cell Development and Function, 2013.
  5. Gomes, Ana Cordeiro. "IDENTIFICATION OF A NEW HEXADENTATE IRON CHELATOR CAPABLE OF RESTRICTING THE INTRAMACROPHAGIC GROWTH OF MYCOBACTERIUM AVIUM.". Paper presented in International BioIron Society Annual Meeting, 2009.
Journal article
  1. Gomes, Ana Cordeiro; Sousa, Daniela Monteiro; Oliveira, Tiago Carvalho; Fonseca, Óscar; Pinto, Ricardo J.; Silvério, Diogo; Fernandes, Ana Isabel; et al. "Serum amyloid A proteins reduce bone mass during mycobacterial infections". Frontiers in Immunology 14 (2023): http://dx.doi.org/10.3389/fimmu.2023.1168607.
    In press • 10.3389/fimmu.2023.1168607
  2. Óscar Fonseca; Maria Salomé Gomes; Maria Adelina Amorim; Ana Cordeiro Gomes. "Cystic Fibrosis Bone Disease: The Interplay between CFTR Dysfunction and Chronic Inflammation". Biomolecules (2023): https://doi.org/10.3390/biom13030425.
    10.3390/biom13030425
  3. Miao, Runfeng; Chun, Harim; Feng, Xing; Gomes, Ana Cordeiro; Choi, Jungmin; Pereira, João P.. "Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-32228-w.
    10.1038/s41467-022-32228-w
  4. Ana C. Moreira; Tânia Silva; Gonçalo Mesquita; Ana Cordeiro Gomes; Clara M. Bento; João V. Neves; Daniela F. Rodrigues; et al. "H-Ferritin Produced by Myeloid Cells Is Released to the Circulation and Plays a Major Role in Liver Iron Distribution during Infection". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms23010269.
    10.3390/ijms23010269
  5. Runfeng Miao, Harim Chun, Ana Cordeiro Gomes, Jungmin Choi, João P. Pereira. "Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size". bioRxiv (2021):
  6. Gonçalo Mesquita; Tânia Silva; Ana C. Gomes; Pedro F. Oliveira; Marco G. Alves; Rui Fernandes; Agostinho A. Almeida; Ana C. Moreira; Maria Salomé Gomes. "H-Ferritin is essential for macrophages’ capacity to store or detoxify exogenously added iron". Scientific Reports 10 1 (2020): https://doi.org/10.1038/s41598-020-59898-0.
    10.1038/s41598-020-59898-0
  7. Tiago Carvalho Oliveira; Maria Salomé Gomes; Ana Cordeiro Gomes. "The Crossroads between Infection and Bone Loss". Microorganisms (2020): https://doi.org/10.3390/microorganisms8111765.
    10.3390/microorganisms8111765
  8. Gomes, Ana Cordeiro; Saraiva, Margarida; Gomes, Maria Salomé. "The bone marrow hematopoietic niche and its adaptation to infection.". Seminars in cell & developmental biology (2020): https://doi.org/10.1016/j.semcdb.2020.05.014.
    10.1016/j.semcdb.2020.05.014
  9. João V. Neves; Gomes, Ana Cordeiro; David M. Costa; Carolina Barroso; Sophie Vaulont; Anabela Cordeiro da Silva; Joana Tavares; Pedro N.S. Rodrigues. "A role for hepcidin in the anemia caused by Trypanosoma brucei infection". Haematologica (2020): http://dx.doi.org/10.3324/haematol.2019.227728.
    10.3324/haematol.2019.227728
  10. Ana Cordeiro Gomes; Ana C. Moreira; Tânia Silva; João V. Neves; Gonçalo Mesquita; Agostinho A. Almeida; Palmira Barreira-Silva; et al. "IFN-¿–Dependent Reduction of Erythrocyte Life Span Leads to Anemia during Mycobacterial Infection". The Journal of Immunology (2019): ji1900382-ji1900382. https://doi.org/10.4049/jimmunol.1900382.
    10.4049/jimmunol.1900382
  11. Ana Cordeiro Gomes; Ana C. Moreira; Gonçalo Mesquita; Maria Salomé Gomes. "Modulation of Iron Metabolism in Response to Infection: Twists for All Tastes". Pharmaceuticals (2018): http://www.mdpi.com/1424-8247/11/3/84.
    10.3390/ph11030084
  12. Nevius, E.; Gomes, A.C.; Pereira, J.P.. "Inflammatory Cell Migration in Rheumatoid Arthritis: A Comprehensive Review". Clinical Reviews in Allergy and Immunology 51 1 (2016): 59-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945537324&partnerID=MN8TOARS.
    10.1007/s12016-015-8520-9
  13. Cordeiro Gomes, A.; Hara, T.; Lim, V.Y.; Herndler-Brandstetter, D.; Nevius, E.; Sugiyama, T.; Tani-ichi, S.; et al. "Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation". Immunity 45 6 (2016): 1219-1231. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006726063&partnerID=MN8TOARS.
    10.1016/j.immuni.2016.11.004
  14. Gomes, A.C.; Gomes, M.S.. "Hematopoietic niches, erythropoiesis and anemia of chronic infection". Experimental Hematology 44 2 (2016): 85-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957551036&partnerID=MN8TOARS.
    10.1016/j.exphem.2015.11.007
  15. Beck, T.C.; Gomes, A.C.; Cyster, J.G.; Pereira, J.P.. "CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow". Journal of Experimental Medicine 211 13 (2014): 2567-2581. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930827084&partnerID=MN8TOARS.
    10.1084/jem.20140457
  16. Fernandes, S.S.; Nunes, A.; Gomes, A.R.; de Castro, B.; Hider, R.C.; Rangel, M.; Appelberg, R.; Gomes, M.S.. "Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium". Microbes and Infection 12 4 (2010): 287-294. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649274461&partnerID=MN8TOARS.
    10.1016/j.micinf.2010.01.003
Preprint
  1. Ana Cordeiro Gomes; Daniela Monteiro Sousa; Tiago Carvalho Oliveira; Óscar Fonseca; Ricardo J. Pinto; Diogo Silvério; Ana Isabel Fernandes; et al. "Serum Amyloid A proteins reduce bone mass during mycobacterial infections". 2022. https://doi.org/10.1101/2022.10.24.513637.
    10.1101/2022.10.24.513637
Thesis / Dissertation
  1. Ana Rita Azevedo Cordeiro Gomes. "Positional regulation of B lymphocyte development in bone marrow". PhD, 2016. https://repositorio-aberto.up.pt/handle/10216/101071.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2015/09/24 Hematopoietic Stem Cells Niches Control B Lymphopoiesis Invited Seminar
Instituto Gulbenkian Ciência (Oeiras, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/10/08 - Current The role of Serum Amyloid A3 protein in bone loss during Mycobacterium avium infection.
Supervisor
 Bioquímica (Master)
Universidade de Aveiro, Portugal
2020/09/01 - 2021/09/30 Impacto da infeção nas células estaminais do nicho hematopoiético
Supervisor
 Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/02/01 - 2021/07/31 Impacto das infeções por micobactérias na homeostase dos hospedeiros
Supervisor
 Bioquímica (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/09/01 - 2019/06/30 Impacto da infeção por Mycobacterium avium na biologia do osso
Supervisor
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/09/01 - 2018/07/01 Impacto da infeção por micobactérias na biologia do osso, baço e fígado
Supervisor
 Biologia (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019/06/19 Impacto da Infeção por Mycobacterium avium na biologia do osso
Supervisor
 Tiago Oliveira (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/07/10 The impact of Ccl2 knock-out on iron metabolism and erythropoiesis
(Thesis) Main arguer
 Jorge Gabriel Oliveira (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Association member

Society Organization name Role
2019/11/05 - Current European Hematology Association EHA Membership number: 078421.
2016/05/01 - Current Portuguese Society for Immunology Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/02/20 - 2021/02/20 "B cell development" - invited to teach a class on the most recent developments on B lymphopoiesis research for the Immunology and Hemato-oncology Course. Metabolismo ¿ Biopatologia e Experimentação (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2019/09/16 - 2020/07/15 Biology of Infection Bioquímica (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/02/11 - 2020/07/15 Microbiology Mestrado Integrado em Medicina (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/02/01 - 2020/07/15 Microbiology Ciências do Meio Aquático (Licenciatura) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/04/19 - 2017/04/19 "Hematopoiese" Lecture for Immunology Class Biologia (Licenciatura) Universidade de Aveiro, Portugal
Distinctions

Award

2021 EHA Kick-Off Grant
European Hematology Association, Netherlands

Other distinction

2018 Junior Investigator (CEECIND/00048/2017)
2016 Postdoctoral Fellowship (NORTE2020HOST07-BPD)
2011 Doctoral Fellowship (SFRH/BD/73782/2010)