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Inês S. Albuquerque concluiu o Mestrado em Microbiologia Aplicada em 2011, e a Licenciatura em Biologia em 2009, pela Universidade de Lisboa. É investigadora e Estudante de Doutoramento / PhD, financiada pela Fundação para a Ciência e Tecnologia (FCT), no Instituto de Medicina Molecular João Lobo Antunes (iMM JLA). Publicou 26 artigos em revistas especializadas. Actua nas áreas de Ciências Biológicas, com ênfase em Microbiologia e Bioquímica, assim como Ciências Médicas e da Saúde com ênfase em Parasitologia e em Biotecnologia Médica e Aplicada à Saúde. __________________________ Inês S. Albuquerque finished her MSc in Applied Microbiology in 2011, and her BSc in Biology in 2009, at the University of Lisbon. Inês is currently a Researcher & PhD Student, with a fellowship awarded by the Portuguese Foundation for Science and Technology (FCT), at the Instituto de Medicina Molecular João Lobo Antunes (iMM JLA). She has published 26 articles at peer-reviewed scientific journals. Inês develops or has developed research in Biological Sciences, more specifically in Microbiology and Biochemistry, as well as in the area of Medical and Health Sciences, specifically Parasitology and Medical Biotechnology.
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Identification

Personal identification

Full name
Maria Inês Sousa de Albuquerque

Citation names

  • Albuquerque, IS
  • Albuquerque, Inês S.
  • Inês S. Albuquerque
  • IS Albuquerque

Author identifiers

Ciência ID
AA13-20AA-F50C
ORCID iD
0000-0002-1108-0961

Email addresses

  • mialbuquerque@medicina.ulisboa.pt (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences
  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Health Sciences - Parasitology
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2)
French Beginner (A1) Elementary (A2) Beginner (A1) Beginner (A1)
Portuguese (Mother tongue)
Education
Degree Classification
2015/10/15 - 2020
Ongoing
 Programa Doutoral do Centro Académico de Medicina de Lisboa (ramo de Medicina; ramo de Ciências Biomédicas; ramo de Ciências e Tecnologias da Saúde) (Doutoramento)
Major in Ciências Biomédicas
Universidade de Lisboa Faculdade de Medicina, Portugal
2009/10 - 2011/10/26
Concluded
 Microbiologia Aplicada (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Cytoadherence capabilities of Plasmodium berghei ANKA and NK65 infected red-blood cells in different malaria models" (THESIS/DISSERTATION)
2006 - 2009/07/15
Concluded
 Biologia (Licenciatura)
Major in Biologia Evolutiva e do Desenvolvimento
Universidade de Lisboa Faculdade de Ciências, Portugal
Affiliation

Science

Category
Host institution 		Employer
2014/06/01 - Current Researcher (Research) Instituto de Medicina Molecular, Portugal
2019/11/06 - 2019/11/29 Visiting Researcher (Research) Instituto de Medicina Molecular, Portugal
University of Cambridge Department of Chemistry, United Kingdom
2011 - 2014 Researcher (Research) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
2012/03/09 - 2012/04/30 Visiting Researcher (Research) Instituto de Medicina Molecular, Portugal
Leids Universitair Medisch Centrum, Netherlands
2010/04/30 - 2011 Research Trainee (Research) Instituto de Medicina Molecular, Portugal
Outputs

Publications

Journal article
  1. Albuquerque, Maria. "Overexpression of Osmosensitive Ca2+-Permeable Channel TMEM63B Promotes Migration in HEK293T Cells". Biochemistry (2019): http://dx.doi.org/10.1021/acs.biochem.9b00224.
    10.1021/acs.biochem.9b00224
  2. Mutter NL; Soskine M; Huang G; Albuquerque IS; Bernardes GJL; Maglia G. "Modular pore-forming immunotoxins with caged cytotoxicity tailored by directed evolution.". ACS chemical biology (2018): http://europepmc.org/abstract/med/30278129.
    10.1021/acschembio.8b00720
  3. Mendes AM; Machado M; Gonçalves-Rosa N; Reuling IJ; Foquet L; Marques C; Salman AM; et al. "A Plasmodium berghei sporozoite-based vaccination platform against human malaria.". NPJ vaccines (2018): http://europepmc.org/abstract/med/30155278.
    10.1038/s41541-018-0068-2
  4. Albuquerque, Maria. "Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability". European Journal of Medicinal Chemistry (2018): https://www.sciencedirect.com/science/article/pii/S0223523418301843.
    10.1016/j.ejmech.2018.02.048
  5. Albuquerque, Maria. "The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer". Journal of the American Chemical Society (2017): http://pubs.acs.org/doi/10.1021/jacs.7b09447.
    10.1021/jacs.7b09447
  6. Max J. H. Worthington; Renata L. Kucera; Inês S. Albuquerque; Christopher T. Gibson; Alexander Sibley; Ashley D. Slattery; Jonathan A. Campbell; et al. "Laying Waste to Mercury: Inexpensive Sorbents Made from Sulfur and Recycled Cooking Oils". Chemistry - A European Journal 23 64 (2017): 16219-16230. https://doi.org/10.1002/chem.201702871.
    10.1002/chem.201702871
  7. Max J. H. Worthington; Renata L. Kucera; Inês S. Albuquerque; Christopher T. Gibson; Alexander Sibley; Ashley D. Slattery; Jonathan A. Campbell; et al. "Cover Feature: Laying Waste to Mercury: Inexpensive Sorbents Made from Sulfur and Recycled Cooking Oils (Chem. Eur. J. 64/2017)". Chemistry - A European Journal 23 64 (2017): 16106-16106. https://doi.org/10.1002/chem.201704108.
    10.1002/chem.201704108
  8. Mendes AM; Albuquerque IS; Machado M; Pissarra J; Meireles P; Prudêncio M. "Inhibition of Plasmodium Liver Infection by Ivermectin.". (2017): http://europepmc.org/abstract/med/27895022.
    10.1128/aac.02005-16
  9. Jiménez-Moreno E; Guo Z; Oliveira BL; Albuquerque IS; Kitowski A; Guerreiro A; Boutureira O; et al. "Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells.". (2017): http://europepmc.org/abstract/med/27930843.
    10.1002/anie.201609607
  10. Bernardim B; Cal PM; Matos MJ; Oliveira BL; Martínez-Sáez N; Albuquerque IS; Perkins E; et al. "Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents.". (2016): http://europepmc.org/abstract/med/27782215.
    10.1038/ncomms13128
  11. Terzic N; Konstantinovic J; Tot M; Burojevic J; Djurkovic-Djakovic O; Srbljanovic J; Štajner T; et al. "Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?". (2016): http://europepmc.org/abstract/med/26640981.
    10.1021/acs.jmedchem.5b01374
  12. Crockett MP; Evans AM; Worthington MJ; Albuquerque IS; Slattery AD; Gibson CT; Campbell JA; et al. "Sulfur-Limonene Polysulfide: A Material Synthesized Entirely from Industrial By-Products and Its Use in Removing Toxic Metals from Water and Soil.". (2016): http://europepmc.org/abstract/med/26481099.
    10.1002/anie.201508708
  13. Orbán Á; Rebelo M; Molnár P; Albuquerque IS; Butykai A; Kézsmárki I. "Efficient monitoring of the blood-stage infection in a malaria rodent model by the rotating-crystal magneto-optical method.". (2016): http://europepmc.org/abstract/med/26983695.
    10.1038/srep23218
  14. Rodrigues CA; Frade RF; Albuquerque IS; Perry MJ; Gut J; Machado M; Rosenthal PJ; et al. "Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids.". (2015): http://europepmc.org/abstract/med/25784585.
    10.1002/cmdc.201500011
  15. Liehl P; Meireles P; Albuquerque IS; Pinkevych M; Baptista F; Mota MM; Davenport MP; Prudêncio M. "Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections.". (2015): http://europepmc.org/abstract/med/25583524.
    10.1128/IAI.02796-14
  16. Amgarten B; Rajan R; Martínez-Sáez N; Oliveira BL; Albuquerque IS; Brooks RA; Reid DG; Duer MJ; Bernardes GJ. "Collagen labelling with an azide-proline chemical reporter in live cells.". (2015): http://europepmc.org/abstract/med/25415185.
    10.1039/c4cc07974d
  17. Albuquerque, Maria. "An artificial CO-releasing metalloprotein built by histidine-selective metallation". Chemical Communications (2015):
    10.1039/C4CC10204E
  18. Chaves-Ferreira M; Albuquerque IS; Matak-Vinkovic D; Coelho AC; Carvalho SM; Saraiva LM; Romão CC; Bernardes GJ. "Spontaneous CO release from Ru(II)(CO)2-protein complexes in aqueous solution, cells, and mice.". (2015): http://europepmc.org/abstract/med/25477186.
    10.1002/anie.201409344
  19. Oliveira R; Guedes RC; Meireles P; Albuquerque IS; Gonçalves LM; Pires E; Bronze MR; et al. "Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials.". (2014): http://europepmc.org/abstract/med/24824551.
    10.1021/jm5004528
  20. Gomes A; Pérez B; Albuquerque I; Machado M; Prudêncio M; Nogueira F; Teixeira C; Gomes P. "N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity.". (2014): http://europepmc.org/abstract/med/24474655.
    10.1002/cmdc.201300459
  21. Miranda D; Capela R; Albuquerque IS; Meireles P; Paiva I; Nogueira F; Amewu R; et al. "Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.". (2014): http://europepmc.org/abstract/med/24900781.
    10.1021/ml4002985
  22. Rodrigues T; Ressurreição AS; da Cruz FP; Albuquerque IS; Gut J; Carrasco MP; Gonçalves D; et al. "Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds.". (2013): http://europepmc.org/abstract/med/24125849.
    10.1016/j.ejmech.2013.09.008
  23. Ressurreição AS; Gonçalves D; Sitoe AR; Albuquerque IS; Gut J; Góis A; Gonçalves LM; et al. "Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability.". (2013): http://europepmc.org/abstract/med/24020770.
    10.1021/jm4011466
  24. Pérez B; Teixeira C; Gomes AS; Albuquerque IS; Gut J; Rosenthal PJ; Prudêncio M; Gomes P. "In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites.". (2013): http://europepmc.org/abstract/med/23290049.
    10.1016/j.bmcl.2012.12.032
  25. Pérez BC; Teixeira C; Albuquerque IS; Gut J; Rosenthal PJ; Gomes JR; Prudêncio M; Gomes P. "N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads.". (2013): http://europepmc.org/abstract/med/23273038.
    10.1021/jm301654b
  26. Bianca Pérez; Cátia Teixeira; Inês S. Albuquerque; Jiri Gut; Philip J. Rosenthal; Miguel Prudêncio; Paula Gomes. "PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity". Med. Chem. Commun. 3 9 (2012): 1170-1170. http://dx.doi.org/10.1039/c2md20113e.
    10.1039/c2md20113e
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/07/15 Unnatural glycopeptides and glycoproteins and their use in antigen detection and immunization 29th International Carbohydrate Symposium
International Carbohydrate Organization (Lisboa, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016 - 2016 9th iMM/CAML PhD Students' Retreat (2016/09/29 - 2016/10/01)
Meeting (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/04/29 - 2019/04/29 Immunology Day - actividades de comunicação científica com interacção com alunos de escolas do ensino secundário, no contexto das celebrações do dia da Imunologia
Other
 Immunology Day
Instituto de Medicina Molecular, Portugal
2018 - 2018 European Researchers' Night - Actividade de disseminação científica que contempla interacção com membros do público como membro representativo do iMM-JLA
Meeting
 Noite Europeia dos Investigadores / European Researchers' Night
Instituto de Medicina Molecular, Portugal
2017 - 2017 European Researchers' Night - Actividade de disseminação científica que contempla interacção com membros do público como membro representativo do iMM-JLA
Meeting
 Noite Europeia dos Investigadores / European Researchers' Night
Instituto de Medicina Molecular, Portugal
2014/09/08 - 2014/09/16 EMBO Practical Course PEPC9: Intensive Practical Course dedicated to modern methods in sample preparation and characterization of proteins for structural studies. Covers cloning and overexpression in bacterial and eukaryotic systems, protein purification with and without tags, sample quality control, sample optimization and crystallization. Hands-on course for researchers in the early stages of their career who wish to learn molecular biology techniques in sample preparation and characterization for structural studies.
Workshop
 EMBO Practical Course: Protein Expression, Purification and Characterization (PEPC9)
European Molecular Biology Laboratory Hamburg, Germany
Distinctions

Other distinction

2015 Bolsa Individual de Doutoramento / PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2014 IMM Pocket Grant (travel expenses to EMBO PEPC9 practical course)
Instituto de Medicina Molecular, Portugal