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Manuel Aureliano Pereira Martins Alves, resident in Faro, was born in the municipality of Gondomar, District of Porto, son of Manuel Martins Alves and Maria Rosa Alves Pereira. Graduated in Biochemistry, Master in Cellular Biology and PhD in Biochemistry (specialty in Bioenergetics) from the University of Coimbra. He is currently an Associate Professor at FCT, with Aggregation in Inorganic Biochemistry, University of Algarve, where he is responsible for the subjects of Biochemistry I, Biochemistry, Inorganic Biochemistry and Advanced Chemistry/Biochemistry for undergraduate courses (BQ, BT, CBM) and master's degrees ( MICF and Biotechnology). Researcher at CCMar where he formed the BioVanádium group. Manuel Aureliano, is the author and/or co-author of 117 scientific publications, and has presented 235 oral and poster communications, 58 lectures in primary and secondary schools, having also participated in 202 juries and supervised and/or co-supervised approximately of 120 students. Reviewer of more than 750 scientific articles in around 110 journals, having been highlighted for this activity on the Publons platform (Top 1%), in addition to being named in the list of "Top 10 reviewers" by Metallomics magazine for 3 consecutive years (2018 , 2019 and 2020). Director and/or member of the Biochemistry degree course committee (UAlg) for 20 years, since 1997/98 he has promoted training, dissemination and research in biochemistry at the University of Algarve, having participated in 20 research projects and/or dissemination of science in schools, in addition to having participated in the organizing and scientific committee of several national and international congresses. Researcher at CCMar since 2006, member of the board of directors of the Portuguese Biochemistry Society (SPB) since 2012, where he has promoted research and dissemination of biochemistry in Portugal. In addition to SPB, he is a member of SPQ and SBIC. Worldwide specialist in studies on "decavanadate" (1st in number of publications) and "vanadate" (5th in number of publications), his main research topics are currently the study of the mechanisms of action of polyoxometalates and metal complexes with antidiabetic properties , anticancer and antibacterial, within the scope of national (Lisbon, Algarve, Leiria, Évora, Coimbra, Aveiro) and international projects and/or collaborations with research groups, for example, from Austria, India, USA, Mexico, Sweden, Australia, Slovakia, Spain and Brazil. In the years 2020, 2021 and 2022, he was included in the "Worlds Top 2% Scientists list" of the most influential scientists in the world, whose published research works have accelerated progress in their respective fields and influenced the work productivity of other researchers: 1 ) "Impact-career" and 2) "Impact year 2020" (https://fct.ualg.pt/17-cientistas-da-ualg-encontram-se-entre-os-mais-citados-nivel-mundial) . In the last 5 years (2018-2023), four of his articles that were published in 2018, 2019, 2021 and 2022 were considered as Highly Cited Papers (top 1% papers in the field of Chemistry).
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Identification

Personal identification

Full name
Manuel Aureliano Pereira Martins Alves

Citation names

  • M. Aureliano
  • Manuel Aureliano

Author identifiers

Ciência ID
AA14-3490-DC5E
ORCID iD
0000-0003-4858-3201
Google Scholar ID
https://scholar.google.pt/citations?user=TId6xlIAAAAJ&hl=en
Researcher Id
https://orcid.org/0000-0003-4858-3201
Scopus Author Id
https://www.scopus.com/authid/detail.uri?authorId=6603412860

Email addresses

  • maalves@ualg.pt (Professional)

Telephones

Telephone
  • 289800900 (Professional)

Addresses

  • FCT, Universidade do Algarve. FCT, Universidade do Algarve, Campus de Gambelas, 8005-139, Faro, Faro, Portugal (Professional)

Websites

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2015
Concluded
 Provas de agregação (Título de Agregado)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Contribuição de decavanadato para os efeitos biológicos de vanádio" (THESIS/DISSERTATION)
 Aprovado por unanimidade
1996
Concluded
 Doutoramento (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Transdução e conjugação energética na Ca-ATPase de retículo sacoplasmático: Interacção de vanadatos" (THESIS/DISSERTATION)
 Aprovado com distinção e louvor por unanimidade
1991/06/04
Concluded
 Biologia Celular (Mestrado)
Major in Não Aplicável
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1986/12/15
Concluded
 Bioquímica (Licenciatura)
Major in Não Aplicável
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
1997/12/02 - 2006/05/31 Assistant Professor (University Teacher) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal

Others

Category
Host institution 		Employer
2006/07/24 - Current Associated Professor of definitive nomination Universidade do Algarve, Portugal
1996/03/01 - 1997/12/31 PhD Researcher, Center Neuroscience of Coimbra Universidade de Coimbra, Portugal
1991/02/01 - 1995/12/31 Assistant researcher at Centro de Neurociências de Coimbra (CNC-UC) Universidade de Coimbra, Portugal
1989/10/02 - 1991/09/11 Monitor Position, Faculdade de Ciências e Tecnologia, Universidade de Coimbra Universidade de Coimbra, Portugal
1987/10/01 - 1990/12/31 Researcher Assistant, Center of Cell Biology Universidade de Coimbra, Portugal
Projects

Contract

Designation Funders
2011/01/01 - 2016/12/31 2011-2015, Projecto PTDC/QUI-BIQ/112943/2009, Caracterização da polaridade em bicamadas lipidicas de fosfolipidos e colesterol e dos seus efeitos em enzimologia menbranar.
PTDC/QUI-BIQ/112943/2009
Researcher
2005/01/01 - 2009/12/31 2005/2008- Projecto POCI/SAU-MMO/57598/2004, Estudo dos possiveis factores ambientais e moleculares que levam ao desenvolvimento de diabetes tipo 2 e obesidade em Portugal (Study of the possible environmental and molecular mechanisms responsible for Insulin Resistance, Type 2 Diabetes and Obesity in
POCI/SAU-MMO/57598/2004
Researcher
2005/01/01 - 2007/12/31 2005/07, Projecto Ciencia Viva VI, PVI-1458, Metais por todo o lado, FCT-UALG/Escola D. Afonso III, Faro. Membro da equipa e coordenador científico-pedagógico.
Projecto Ciencia Viva VI, PVI-1458
Researcher
2005/01/01 - 2006/12/31 2005/2006, Projecto CRUP, E-106/05. “Oxidative stresse in the contractile system induced by metal ions” em colaboração com Dr Carlos Merino, Univ. Extremadura
Projecto CRUP, E-106/05.
Researcher
2002/01/01 - 2005/12/31 POCT/QUI/38191/2001-“Cadmium and vanadium compounds interactions with calcium pump
POCT/QUI/38191/2001
Principal investigator
2001/01/01 - 2005/12/31 2001/2005, Projecto Cost D21: “Insulin-mimetic actions of vanadium compounds”. Membro da equipa, (PI) D. Redher, Germany
Projecto Cost D21
Researcher
Concluded
2001/01/01 - 2004/01/01 2001/2004, POCTI/BME/34701/99, “Structure and function of elicitins and their role in the cork oak infection by the fungus Phytophora cinnamomi
POCTI/BME/34701/99
Researcher
2000/10/01 - 2003/09/30 POCTI/34668/Fis/2000 -“Field effect transition array for monitoring electrical activity from single cell culture
POCTI/34668/Fis/2000
Researcher
Concluded
2000/10 - 2003/09 POCTI/34668/Fis/2000 -“Field effect transition array for monitoring electrical activity from single cell culture
POCTI/34668/Fis/2000
 N/A
2000/01/01 - 2002/12/31 2000-2002- Projecto Ciência Viva, PIV-041 “A química dos metais e as interfaces com as ciências biológicas” (EB 2,3 Afonso III, Faro) Coordenador científico-pedagógico
Projecto Ciência Viva, PIV-041
Researcher
Concluded
2000/01 - 2002/12 2000-2002- Projecto Ciência Viva, PIV-041 “A química dos metais e as interfaces com as ciências biológicas” (EB 2,3 Afonso III, Faro) Coordenador científico-pedagógico
Projecto Ciência Viva, PIV-041
 N/A
1998/01/01 - 1999/12/31 1998/99, Projecto Ciência Viva, PIII-101, Influência de Alterações Ambientais nos Seres Vivos - Métodos Laboratoriais Interdisciplinares da Biologia e da Química (EB2,3 Afonso III, Faro) Coordenador científico-pedagógico
Projecto Ciência Viva, PIII-101
Researcher
1988/01/01 - 1999/12/31 1998/99, Projecto Ciência Viva, PIII-311, Poluição das Águas e Solos no Concelho de Oliveira do Bairro, EB2,3 Dr Acácio de Azevedo, Oliveira do Bairro, Coordenador científico-pedagógico.
Projecto Ciência Viva, PIII-311
Researcher
Concluded
1997/01/01 - 1998/12/31 1997/98, Projecto Ciência Viva, PII-223, Poluentes atmosféricos e seus efeitos na saúde: métodos laboratoriais interdisciplinares da biologia e da química (EB2,3 Dr Acácio de Azevedo, Oliveira do Bairro) Ana Lima (Coordenador), M. Aureliano, Coordenador científico-pedagógico.
Projecto Ciência Viva, PII-223
Researcher
1997/01/01 - 1998/12/31 1997/98, Projecto Ciência Viva, PII-311, Conservação e Valorização do patrimonio natural e cultural do Oppidum de Conimbriga e das terras de Sicó", Museu de Conímbriga, Coordenador.
Projecto Ciência Viva, PII-311
Researcher
1997/01/01 - 1998/12/31 1997/98, Projecto Ciência Viva, PII-312, Estudo do Ambiente no Território do Oppidum de Conimbriga/Terras de Sicó, Museu de Conímbriga, Coordenador científico-pedagógico.
Projecto Ciência Viva, PII-312
Researcher
1994/01/01 - 1998/12/31 Muscle Network Contract ERBCHRXCT-940606, EU, 100.000 ECU,1994-1998.
ERBCHRXCT-940606
Researcher
Outputs

Publications

Book
  1. Ramos, S.; Moura, J.J.G.; Aureliano, M.. A comparison between vanadyl, vanadate and decavanadate effects in actin structure and function: Combination of several spectroscopic studies. 2013.
    10.3233/978-1-61499-184-7-261
  2. Tiago, T.; Silva, D.; Samhan-Arias, A. K.; Aureliano, M.; Gutierrez-Merino, C.. Actin cytoskeleton disruption is an early event upon exposure of cerebellar granule neurons to SIN-1-induced oxidative stress. 2009.
  3. Aureliano, M.. Vanadium biochemistry. Portugal: Research SignPost. 2007.
Book chapter
  1. Aureliano, M.. "Decavanadate interactions with sarcoplasmic reticulum calcium pump". Portugal: Research Signpost,
  2. Tiago, Teresa; Gutiérrez-Merino, Carlos; Aureliano, M.. "Monomeric versus decameric vanadate in the elucidation of muscle contraction regulation: a kinetic, spectroscopic and structural overview". Portugal: Research SignPost,
  3. Soares, S. S.; Gutiérrez-Merino, Carlos; Aureliano, M.. "Decavanadate toxicity effects following in vivo administration". Portugal: Research Signpost,
  4. Aureliano, M.. "Biological effects of decavanadate: muscle contraction, in vivo oxidative stress, and mitochondrial toxicity". Portugal: American Chemical Society Symposium series,
  5. Tiago, Daniel M.; Laizé, Vincent; Aureliano, M.; Cancela, Leonor. "Vanadate effects on bone metabolism: fish cell lines as an alternative to mammalian in vitro systems". Portugal: Research Signpost,
  6. Tiago, Teresa; Aureliano, M.; Gutiérrez-Merino, Carlos. "Effects of reactive oxygen and nitrogen species on actomyosin and their implications for muscle contractility". Portugal: Research Signpost,
Conference paper
  1. Aureliano, M.. "A bioquímica na sociedade". 2014.
  2. M. Aureliano. "Effects of decavanadate in cardiac myocytes". 2007.
  3. M. Aureliano. "Decavanadate toxicity". 2007.
  4. Aureliano, M.; Soares, S. S.; Henao, Fernando; Gutiérrez-Merino, Carlos. "The pathways of cell death in cardiomyocytes induced by vanadate". 2007.
Journal article
  1. Maria Berrocal; Juan J. Cordoba-Granados; Sónia A. C. Carabineiro; Carlos Gutierrez-Merino; Manuel Aureliano; Ana M. Mata. "Gold Compounds Inhibit the Ca2+-ATPase Activity of Brain PMCA and Human Neuroblastoma SH-SY5Y Cells and Decrease Cell Viability". Metals (2021): https://doi.org/10.3390/met11121934.
    10.3390/met11121934
  2. Manuel Aureliano; Nadiia I. Gumerova; Giuseppe Sciortino; Eugenio Garribba; Annette Rompel; Debbie C. Crans. "Polyoxovanadates with emerging biomedical activities". Coordination Chemistry Reviews 447 (2021): 214143-214143. https://doi.org/10.1016/j.ccr.2021.214143.
    10.1016/j.ccr.2021.214143
  3. Cristina Amante; Ana Luísa De Sousa-Coelho; Manuel Aureliano. "Vanadium and Melanoma: A Systematic Review". Metals 11 5 (2021): 828-828. https://doi.org/10.3390/met11050828.
    10.3390/met11050828
  4. Giuseppe Sciortino; Manuel Aureliano; Eugenio Garribba. "Rationalizing the Decavanadate(V) and Oxidovanadium(IV) Binding to G-Actin and the Competition with Decaniobate(V) and ATP". Inorganic Chemistry 60 1 (2021): 334-344. https://doi.org/10.1021/acs.inorgchem.0c02971.
    10.1021/acs.inorgchem.0c02971
  5. Custódia Fonseca; Gil Fraqueza; Sónia A. C. Carabineiro; Manuel Aureliano. "The Ca2+-ATPase Inhibition Potential of Gold(I, III) Compounds". Inorganics 8 9 (2020): 49-49. https://doi.org/10.3390/inorganics8090049.
    10.3390/inorganics8090049
  6. Catarina Pimpão; Inês V. da Silva; Andreia F. Mósca; Jacinta O. Pinho; Maria Manuela Gaspar; Nadiia I. Gumerova; Annette Rompel; Manuel Aureliano; Graça Soveral. "The Aquaporin-3-Inhibiting Potential of Polyoxotungstates". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21072467.
    10.3390/ijms21072467
  7. Fraqueza, Gil; Fuentes, Juan; Krivosudský, Lukáš; Dutta, Saikat; Mal, Sib Sankar; Roller, Alexander; Giester, Gerald; Rompel, Annette; Aureliano, Manuel. "Inhibition of Na+/K+- and Ca2+-ATPase activities by phosphotetradecavanadate". Journal of Inorganic Biochemistry 197 (2019): 110700. http://dx.doi.org/10.1016/j.jinorgbio.2019.110700.
    10.1016/j.jinorgbio.2019.110700
  8. Marques-da-Silva, Dorinda; Fraqueza, Gil; Lagoa, Ricardo; Vannathan, Anjana Anandan; Mal, Sib Sankar; Aureliano, Manuel; Dorinda Marques-da-Silva; et al. "Polyoxovanadate inhibition of Escherichia coli growth shows a reverse correlation with Ca2+-ATPase inhibition". New Journal of Chemistry 43 45 (2019): 17577-17587. http://dx.doi.org/10.1039/c9nj01208g.
    10.1039/c9nj01208g
  9. Bijelic, Aleksandar; Aureliano, Manuel; Rompel, Annette. "Im Kampf gegen Krebs: Polyoxometallate als nächste Generation metallhaltiger Medikamente". Angewandte Chemie 131 10 (2018): 3008-3029. http://dx.doi.org/10.1002/ange.201803868.
    10.1002/ange.201803868
  10. M. Aureliano; Bijelic, Aleksandar; Aureliano, Manuel; Rompel, Annette. "Polyoxometalates as potential next-generation metallodrugs in the combat against cancer". Angewandte Chemie International Edition 58 10 (2018): 2980-2999. http://dx.doi.org/10.1002/anie.201803868.
    10.1002/anie.201803868
  11. Gumerova N; Krivosudský L; Fraqueza G; Breibeck J; Al-Sayed E; Tanuhadi E; Bijelic A; et al. "The P-type ATPase inhibiting potential of polyoxotungstates.". Metallomics : integrated biometal science 10 2 (2018): 287-295. http://europepmc.org/abstract/med/29313547.
    10.1039/c7mt00279c
  12. M. Aureliano. "Peroxynitrite versus decavanadate protein oxidative modifications: the case of myosin". (2018):
  13. M. Aureliano. "Outstanding Reviewers for Metallomics in 2017". (2018):
  14. Aleksandar Bijelic; Manuel Aureliano; Annette Rompel. "The antibacterial activity of polyoxometalates: structures, antibiotic effects and future perspectives". Chemical Communications 54 10 (2018): 1153-1169. https://doi.org/10.1039/C7CC07549A.
    10.1039/C7CC07549A
  15. M. Aureliano. "Polyoxometalates as inhibitors of P-type ATPases and the role of polyphenols". ISANH, Vol. 5, Issue 2, 2017 (2017):
    10.18143/AISANH_v5i2_7
  16. Marques MPM; Gianolio D; Ramos S; Batista de Carvalho LAE; Aureliano M. "An EXAFS Approach to the Study of Polyoxometalate-Protein Interactions: The Case of Decavanadate-Actin.". Inorganic chemistry (2017): http://europepmc.org/abstract/med/28858484.
    10.1021/acs.inorgchem.7b01018
  17. Fonseca TG; Morais MB; Rocha T; Abessa DM; Aureliano M; Bebianno MJ. "Ecotoxicological assessment of the anticancer drug cisplatin in the polychaete Nereis diversicolor.". The Science of the total environment (2017): http://europepmc.org/abstract/med/27744150.
    10.1016/j.scitotenv.2016.09.185
  18. NUTTAPORN SAMART; JESSICA SAEGER; KENNETH J. HALLER; MANUEL AURELIANO; DEBBIE C. CRANS. "INTERACTION OF DECAVANADATE WITH INTERFACES AND BIOLOGICAL MODEL MEMBRANE SYSTEMS: CHARACTERIZATION OF SOFT OXOMETALATE SYSTEMS". Journal of Molecular and Engineering Materials 02 01 (2014): 1440007-1440007. https://doi.org/10.1142%2Fs2251237314400073.
    10.1142/s2251237314400073
  19. Aureliano, M.. "Decavanadate contribution to vanadium biochemistry: In vitro and in vivo studies". Inorganica Chimica Acta 420 (2014): 4-7. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903265782&partnerID=MN8TOARS.
    10.1016/j.ica.2013.10.010
  20. Aureliano, M.; Ohlin, C. Andre. "Decavanadate in vitro and in vivo effects: facts and opinions". Journal of Inorganic Biochemistry 137 (2014): 123-130.
    10.1016/j.jinorgbio.2014.05.002
  21. Aureliano, M.; Fraqueza, G.; Ohlin, C.A.. "Ion pumps as biological targets for decavanadate". Dalton Transactions 42 33 (2013): 11770-11777. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881144038&partnerID=MN8TOARS.
    10.1039/c3dt50462j
  22. Aureliano, M.; Nolasco, P.A.; Da Silva, J.J.R.F.; Da Silva, J.A.L.. "Metalloids in origin and evolution of life,Os semimetais na origem e evolução da vida". Quimica Nova 35 5 (2012): 1062-1068. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864221679&partnerID=MN8TOARS.
  23. Fraqueza, Gil; Batista de Carvalho, Luis A E; Marques, M Paula M; Maia, Luisa; Ohlin, C Andre; Casey, William H; Aureliano, Manuel; et al. "Decavanadate, decaniobate, tungstate and molybdate interactions with sarcoplasmic reticulum Ca(2+)-ATPase: quercetin prevents cysteine oxidation by vanadate but does not reverse ATPase inhibition.". Dalton transactions (Cambridge, England : 2003) 41 41 (2012): 12749-58. http://hdl.handle.net/10400.1/1653.
    10.1039/c2dt31688a
  24. Fraqueza, G.; Ohlin, C.A.; Casey, W.H.; Aureliano, M.; Fraqueza, Gil; Ohlin, C. André; Casey, William H.. "Sarcoplasmic reticulum calcium ATPase interactions with decaniobate, decavanadate, vanadate, tungstate and molybdate". Journal of Inorganic Biochemistry 107 1 (2012): 82-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455225673&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2011.10.010
  25. Ramos, S.; Moura, J.J.G.; Aureliano, M.; Ramos, Susana; Moura, José J. G.. "Recent advances into vanadyl, vanadate and decavanadate interactions with actin". Metallomics 4 1 (2012): 16-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855427953&partnerID=MN8TOARS.
    10.1039/c1mt00124h
  26. Ramos, S.; Moura, J.J.G.; Aureliano, M.. "A comparison between vanadyl, vanadate, and decavanadate effects in actin structure and function: Combination of several spectroscopic studies". Spectroscopy (New York) 27 5-6 (2012): 355-359. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866256538&partnerID=MN8TOARS.
    10.1155/2012/532904
  27. Manuel Aureliano; Pedro A. Nolasco; João J. R. Fraústo da Silva; José Armando L. da Silva; Aureliano, M.; Nolasco, Pedro A.; Silva, João J. R. Fraústo da; Silva, José Armando L.. "Os semimetais na origem e evolução da vida". Química Nova 35 5 (2012): 1062-1068. https://doi.org/10.1590%2Fs0100-40422012000500036.
    10.1590/s0100-40422012000500036
  28. Aureliano M; Aureliano, M.. "Recent perspectives into biochemistry of decavanadate.". World journal of biological chemistry (2011): http://europepmc.org/abstract/med/22031844.
    10.4331/wjbc.v2.i10.215
  29. Ramos, S.; Almeida, R.M.; Moura, J.J.G.; Aureliano, M.; Ramos, Susana; Almeida, Rui M.; Moura, José J. G.. "Implications of oxidovanadium(IV) binding to actin". Journal of Inorganic Biochemistry 105 6 (2011): 777-783. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955088456&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2011.02.010
  30. Ramos, S.; Moura, J.J.G.; Aureliano, M.; Ramos, Susana; Moura, Jose J. G.; Aureliano, Manuel. "Actin as a potential target for decavanadate". Journal of Inorganic Biochemistry 104 12 (2010): 1234-1239. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957140990&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2010.08.001
  31. Aureliano, M.. "Decavanadate: A journey in a search of a role". Dalton Transactions 42 (2009): 9093-9100. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350236759&partnerID=MN8TOARS.
    10.1039/b907581j
  32. Ramos, S.; Duarte, R.O.; Moura, J.J.G.; Aureliano, M.. "Decavanadate interactions with actin: Cysteine oxidation and vanadyl formation". Dalton Transactions 38 (2009): 7985-7994. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349324694&partnerID=MN8TOARS.
    10.1039/b906255f
  33. Aureliano, M.; Crans, D.C.. "Decavanadate (V10 O286 -) and oxovanadates: Oxometalates with many biological activities". Journal of Inorganic Biochemistry 103 4 (2009): 536-546. http://www.scopus.com/inward/record.url?eid=2-s2.0-62349083550&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2008.11.010
  34. Tiago, D.M.; Cancela, M.L.; Aureliano, M.; Laizé, V.; Tiago, Daniel M.; Cancela, Leonor; Laizé, Vincent. "Vanadate proliferative and anti-mineralogenic effects are mediated by MAPK and PI-3K/Ras/Erk pathways in a fish chondrocyte cell line". FEBS Letters 582 9 (2008): 1381-1385. http://www.scopus.com/inward/record.url?eid=2-s2.0-41449118290&partnerID=MN8TOARS.
    10.1016/j.febslet.2008.03.025
  35. Tiago, D.M.; Laizé, V.; Cancela, M.L.; Aureliano, M.; Tiago, Daniel M.; Laizé, Vincent; Cancela, Leonor. "Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line". Cell Biology and Toxicology 24 3 (2008): 253-263. http://www.scopus.com/inward/record.url?eid=2-s2.0-42549166545&partnerID=MN8TOARS.
    10.1007/s10565-007-9034-x
  36. Soares, S.S.; Martins, H.; Gutiérrez-Merino, C.; Aureliano, M.. "Vanadium and cadmium in vivo effects in teleost cardiac muscle: Metal accumulation and oxidative stress markers". Comparative Biochemistry and Physiology - C Toxicology and Pharmacology 147 2 (2008): 168-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-37349119851&partnerID=MN8TOARS.
    10.1016/j.cbpc.2007.09.003
  37. Soares, S.S.; Henao, F.; Aureliano, M.; Gutiérrez-Merino, C.; Soares, S. S.; Henao, Fernando; Gutiérrez-Merino, Carlos. "Vanadate induces necrotic death in neonatal rat cardiomyocytes through mitochondrial membrane depolarization". Chemical Research in Toxicology 21 3 (2008): 607-618. http://www.scopus.com/inward/record.url?eid=2-s2.0-41849134685&partnerID=MN8TOARS.
    10.1021/tx700204r
  38. Aureliano, M.; Soares, S.S.; Tiago, T.; Ramos, S.; Gutiérrez-Merino, C.. "Biological effects of decavanadate: Muscle contraction, in vivo oxidative stress, and mitochondrial toxicity". ACS Symposium Series 974 (2007): 249-263. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749016168&partnerID=MN8TOARS.
  39. Soares, Sandra S.; Gutierrez-Merino, Carlos; Aureliano, Manuel; Soares, S. S.; Gutiérrez-Merino, Carlos; Aureliano, M.. "Mitochondria as a target for decavanadate toxicity in Sparus aurata heart". Aquatic Toxicology 83 1 (2007): 1-9. http://hdl.handle.net/10400.1/1318.
    10.1016/j.aquatox.2007.03.005
  40. Soares, S.S.; Martins, H.; Duarte, R.O.; Moura, J.J.G.; Coucelo, J.; Gutiérrez-Merino, C.; Aureliano, M.; et al. "Vanadium distribution, lipid peroxidation and oxidative stress markers upon decavanadate in vivo administration". Journal of Inorganic Biochemistry 101 1 (2007): 80-88. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845298943&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2006.08.002
  41. Tiago, T.; Simao, S.; Aureliano, M.; Martin-Romero, F. J.; Gutierrez-Merino, C.; Tiago, Teresa; Simão, Sónia; Martín-Romero, Francisco Javier; Gutiérrez-Merino, Carlos. "Inhibition of skeletal muscle S1-myosin ATPase by peroxynitrite". Biochemistry 45 11 (2006): 3794-3804. http://hdl.handle.net/10400.1/1355.
    10.1021/bi0518500
  42. Aureliano, M.; Tiago, T.; Gândara, R.M.C.; Sousa, A.; Moderno, A.; Kaliva, M.; Salifoglou, A.; et al. "Interactions of vanadium(V)-citrate complexes with the sarcoplasmic reticulum calcium pump". Journal of Inorganic Biochemistry 99 12 (2005): 2355-2361. http://www.scopus.com/inward/record.url?eid=2-s2.0-28444444952&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2005.09.002
  43. Gândara, R.M.C.; Soares, S.S.; Martins, H.; Gutiérrez-Merino, C.; Aureliano, M.. "Vanadate oligomers: In vivo effects in hepatic vanadium accumulation and stress markers". Journal of Inorganic Biochemistry 99 5 (2005): 1238-1244. http://www.scopus.com/inward/record.url?eid=2-s2.0-17044432274&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2005.02.023
  44. Tiago, T.; Aureliano, M.; Gutierrez-Merino, C.; Tiago, Teresa; Gutiérrez-Merino, Carlos. "Decavanadate binding to a high affinity site dear the myosin catalytic centre inhibits F-actin-stimulated myosin ATPase activity". Biochemistry 43 18 (2004): 5551-5561. http://hdl.handle.net/10400.1/1358.
    10.1021/bi049910+
  45. Soares, S.S.; Aureliano, M.; Joaquim, N.; Coucelo, J.M.. "Cadmium and vanadate oligomers effects on methaemoglobin reductase activity from Lusitanian toadfish: In vivo and in vitro studies". Journal of Inorganic Biochemistry 94 3 (2003): 285-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344406884&partnerID=MN8TOARS.
    10.1016/S0162-0134(03)00006-0
  46. Tiago, T.; Aureliano, M.; Gutiérrez-Merino, C.. "Quenching of Myosin Intrinsic Fluorescence Unravels the Existence of a High Affinity Binding Site for Decavanadate". Journal of Fluorescence 12 1 (2002): 87-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-0012182159&partnerID=MN8TOARS.
    10.1023/A:1015371422083
  47. Aureliano, M.; Joaquim, N.; Sousa, A.; Martins, H.; Coucelo, J.M.. "Oxidative stress in toadfish (Halobactrachus didactylus) cardiac muscle - Acute exposure to vanadate oligomers". Journal of Inorganic Biochemistry 90 3-4 (2002): 159-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037036051&partnerID=MN8TOARS.
    10.1016/S0162-0134(02)00414-2
  48. Aureliano, M.; Pedroso, M.C.; De Lima; Carvalho, A.P.; Pires, E.M.V.. "Effect of myosin phosphorylation on actomyosin ATPase activity: a flow microcalorimetric study". Thermochimica Acta 258 C (1995): 59-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243321608&partnerID=MN8TOARS.
    10.1016/0040-6031(94)02192-Q
  49. Aureliano, M.; Leta, J.; Madeira, V. M. C.; Demeis, L.. "THE CLEAVAGE OF PHOSPHOENOLPYRUVATE BY VANADATE". Biochemical and Biophysical Research Communications 201 1 (1994): 155-159.
    10.1006/bbrc.1994.1682
  50. Aureliano, M.; Madeira, V. M. C.. "INTERACTIONS OF VANADATE OLIGOMERS WITH SARCOPLASMIC-RETICULUM CA2+-ATPASE". Biochimica Et Biophysica Acta-Molecular Cell Research 1221 3 (1994): 259-271.
    10.1016/0167-4889(94)90249-6
  51. Aureliano, M.; Madeira, V. M. C.. "VANADATE OLIGOANIONS INTERACT WITH THE PROTON EJECTION BY THE CA2+ PUMP OF SARCOPLASMIC-RETICULUM". Biochemical and Biophysical Research Communications 205 1 (1994): 161-167.
    10.1006/bbrc.1994.2644
  52. Amado, A. M.; Aureliano, M.; Ribeiroclaro, P. J. A.; Teixeiradias, J. J.. "COMBINED RAMAN AND V-51 NMR SPECTROSCOPIC STUDY OF VANADIUM (V) OLIGOMERIZATION IN AQUEOUS ALKALINE-SOLUTIONS". Journal of Raman Spectroscopy 24 10 (1993): 699-703.
    10.1002/jrs.1250241011
  53. Geraldes, Cfgc; Castro, Mmca; Saraiva, M. E.; Aureliano, M.; Dias, B. A.. "INTERACTION OF MONOSACCHARIDES AND RELATED-COMPOUNDS WITH OXOCATIONS OF MO(VI), W(VI) AND U(VI) STUDIED BY NMR-SPECTROSCOPY". Journal of Coordination Chemistry 17 3 (1988): 205-219.
    10.1080/00958978808070771

Other

Other output
  1. The role of decavanadate in anti-tumor activity. Decavanadate compounds were described to be involved in a variety of biological activities and responses such as anti-virus, anti-bacterial and anticancer. While the mechanisms of action of the antiviral and anti-bacterial activities are better understood, the same does not go for the anti-tumour activity. Nevertheless, the inhibition of tumour proliferation seems to impact certain enzymes such as. 2017. Aureliano, M.. http://hdl.handle.net/10400.1/10265.
  2. Characterization of decavanadate and decaniobate solutions by Raman spectroscopy. The decaniobate ion, (Nb10 = [Nb10O28]6-) being isoelectronic and isostructural with the decavanadate ion (V10 = [V10O28]6-), but chemically and electrochemically more inert, has been useful in advancing the understanding of V10 toxicology and pharmacological activities. In the present study, the solution chemistry of Nb10 and V10 between pH 4 and 12 is studied by Raman spectroscopy. The Raman spe. 2016. Aureliano, M.; Ohlin, C. André; Vieira, Michele O.; Marques, M. Paula M.; Casey, William H.; Batista de Carvalho, Luís A. E.; Aureliano M; et al. http://hdl.handle.net/10400.1/8011.
    https://dx.doi.org/10.1039/c5dt04176g
  3. Decavanadate contribution to vanadium biomarkers. The levels of vanadium in urine and blood can be used as biomarkers of exposure, but the mechanism of vanadium toxicity is of major relevance in order to understand how biomarkes can be valuable. Our research group has performed in vivo and in vitro studies using fish and rat models to analysed and compare the toxicity effects induce by vanadium(V) species in the forms of vanadate (V1) and decavan. 2016. Aureliano, M.. http://hdl.handle.net/10400.1/10267.
    10.4172/2471-8556.C1.003
  4. Decavanadate toxicology and pharmacological activities: V10 or V1, both or none?. This review covers recent advances in the understanding of decavanadate toxicology and pharmacological applications. Toxicological in vivo studies point out that V10 induces several changes in several oxidative stress parameters, different from the ones observed for vanadate (V1). In in vitro studies with mitochondria, a particularly potent V10 effect, in comparison with V1, was observed in the mi. 2016. Aureliano, M.; Aureliano M. http://hdl.handle.net/10400.1/7997.
    http://dx.doi.org/10.1155/2016/6103457
  5. Recent insights into anatoxin-achemical synthesis, biomolecular targets, mechanisms of action and LC-MS detection. 2015. Custódia Fonseca; Manuel Aureliano; Feras Abbas; Ambrose Furey; Fonseca, C.; Aureliano, M.; Abbas, F.; Furey, A.. https://doi.org/10.1002%2F9781118500354.ch7.
    10.1002/9781118500354.ch7
  6. Cyclosporine A and tacrolimus reduce the amount of GLUT4 at the cell-surface in human adipocytes: increased endocytosis as a potential mechanism for the diabetogenic effects of immunosuppressive agents. Context:Immunosuppressive agentes are associated with profound metabolic side effects including new-onset diabetes and dyslipidemia after organ transplantation. Objective: Toi nvestigated the effects of the cyclosporine A(CsA)or tacrolimus ong lucose uptake and insulin signalling in human adipocytes and their impact on the regulation of celular trafficking of the glucose transporter 4 (GLUT4). Des. 2014. Pereira, Maria João; Aureliano, M.; Palming, Jenny; Rizell, Magnus; Carvalho, Eugénia; Svensson, Maria K.; Eriksson, Jan W.; et al. http://hdl.handle.net/10400.1/4856.
    http://dx.doi.org/10.1210/jc.2014-1266
  7. Metais na bioquímica e na medicina. A Bioquímica ou Química da Vida representa uma ciência interdisciplinar que utiliza estratégias e métodos de todas as Ciências Exactas e Naturais. Nos últimos 10 anos, catorze prémios Nobel da Química, Fisiologia e Medicina foram atribuídos na área da Bioquímica o que reflecte a importância desta área de conhecimento nas Sociedades contemporâneas. A Bioquímica não se reduz apenas ao estudo dos com. 2014. Aureliano, M.. http://hdl.handle.net/10400.1/4897.
  8. A química da vida. A Bioquímica ou Química da Vida é uma ciência interdisciplinar que utiliza estratégias e métodos de todas as Ciências Exactas e Naturais. Nos últimos 10 anos, foram catorze os prémios Nobel da Química, Fisiologia e Medicina que foram atribuídos na área da Bioquímica o que reflecte a importância desta área de conhecimento nas Sociedades contemporâneas. A Química da Vida não se reduz apenas ao estud. 2014. Aureliano, M.. http://hdl.handle.net/10400.1/4882.
  9. Interaction of decavanadate with interfaces and biological modelmembranesystems:Haracterization of soft oxometale systems. Decavanadate is a polyoxometalate consisting of 10 octahedral vanadium centers, which has been found to exert biological effects and has been observed in vivo. Biological activity implies that a material is taken up into a cell or that the material interacts with membrane receptors. Because of the large size and the high molecular charge, it is nontrivial to anticipate how such a large anion inter. 2014. Aureliano, M.; Samart, Nuttaporn; Saeger, Jessica; Haller, Kenneth J.; Crans, Debbie C.. http://hdl.handle.net/10400.1/4607.
    http://dx.doi.org/ 10.1142/S2251237314400073
  10. Ion pumps as biological targets for decavanadate. The putative applications of poly-, oligo- and mono-oxometalates in biochemistry, biology, pharmacology and medicine are rapidly attracting interest. In particular, these compounds may act as potent ion pump inhibitors and have the potential to play a role in the treatment of e.g. ulcers, cancer and ischemic heart disease. However, the mechanism of action is not completely understood in most cases. 2013. Aureliano, M.. http://hdl.handle.net/10400.1/2699.
  11. The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue. Cyclosporin A (CsA), tacrolimus and rapamycin are immunosuppressive agents (IAs) associated with insulin resistance and dyslipidemia, although their molecular effects on lipid metabolism in adipose tissue are unknown. We explored IAs effects on lipolysis, lipid storage and expression of genes involved on lipid metabolism in isolated human adipocytes and/or adipose tissue obtained via subcutaneous. 2013. Pereira, Maria João; Palming, Jenny; Rizell, Magnus; Aureliano, M.; Carvalho, Eugénia; Svensson, Maria K.; Eriksson, Jan W.; et al. http://hdl.handle.net/10400.1/2066.
    10.1016/j.mce.2012.10.030
  12. A comparison between Vanadyl, Vanadate, and decavanadate effects in actin structure and function: combination of several spectroscopic studies. The studies about the interaction of actin with vanadium are seldom. In the present paper the effects of vanadyl, vanadate, and decavanadate in the actin structure and function were compared. Decavanadate clearly interacts with actin, as shown by 51V-NMR spectroscopy. Decavanadate interaction with actin induces protein cysteine oxidation and vanadyl formation, being both prevented by the natural l. 2012. Aureliano, M.. http://hdl.handle.net/10400.1/1449.
  13. Functional and Structural Interactions of Nb, V, Mo and W Oxometalates with the Sarcoplasmic Reticulum Ca2+-ATPase Reveal New Insights Into Inhibition Processes: a Combination of NMR, Raman, AA and EPR Spectroscopies with Kinetic Studies. 2012. Fraqueza, G; Batista de Carvalho, LAE; Marques, MPM; Ohlin, CA; Casey, WH; Aureliano, M. http://hdl.handle.net/10316/45091.
  14. mTOR inhibition with rapamycin cause impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes. Rapamycin is an immunosuppressive agent used after organ transplantation, but its molecular effects on glucose metabolism needs further evaluation. We explored rapamycin effects on glucose uptake and insulin signalling proteins in adipocytes obtained via subcutaneous (n = 62) and omental (n = 10) fat biopsies in human donors. At therapeutic concentration (0.01 lM) rapamycin reduced basal and insul. 2012. Pereira, Maria João; Palming, Jenny; Rizell, Magnus; Aureliano, M.; Carvalho, Eugénia; Svensson, Maria K.; Eriksson, Jan W.; et al. http://hdl.handle.net/10400.1/1326.
    10.1016/j.mce.2012.01.024
  15. Effect of harvesting stress and storage conditions on protein degradation in fillets of farmed gilthead seabream (Sparus aurata): a differential scanning calorimetry study. A trial was undertaken to evaluate Differential Scanning Calorimetry (DSC) as a fast analytical tool to differentiate gilthead seabream subjected to variable conditions of slaughter stress and post-mortem storage. Fish were subjected to different harvesting stress conditions: profound anaesthesia (PA, low stress) and net crowding (NC, high stress). Fish were slaughtered in an ice-salt water slurry. 2011. Matos, Elisabete; Silva, Tomé S.; Tiago, Teresa; Aureliano, M.; Dinis, Maria Teresa; Dias, J.; Matos, E.; et al. http://hdl.handle.net/10400.1/1322.
    10.1016/j.foodchem.2010.11.017
  16. Early disruption of the actin cytoskeleton in cultured cerebellar granule neurons exposed to 3-morpholinosydnonimine-oxidative stress is linked to alterations of the cytosolic calcium concentration. Cytoskeleton damage is a frequent feature in neuronal cell death and one of the early events in oxidantinduced cell injury. This work addresses whether actin cytoskeleton reorganization is an early event of SIN-1-induced extracellular nitrosative/oxidative stress in cultured cerebellar granule neurons (CGN). The actin polymerization state, i.e. the relative levels of G-/F-actin, was quantitatively. 2011. Tiago, Teresa; Marques-da-Silva, Dorinda; Samhan-Arias, A. K.; Aureliano, M.; Gutiérrez-Merino, Carlos; Tiago, T.; Marques-da-Silva, D.; Samhan-Arias, A.K.; Gutierrez-Merino, C.. http://hdl.handle.net/10400.1/1323.
    10.1016/j.ceca.2011.01.009
  17. Peroxynitrite-mediated oxidative modifications of myosin and implications on structure and function. The peroxynitrite-induced functional impairment of myosin was studied in different reaction conditions, known to alter the oxidative chemistry of peroxynitrite, to better understand the molecular mechanisms of this interaction. It is shown that peroxynitrite is able to enhance the basal MgATPase activity up to 2-fold while inhibiting the actin-stimulated ATPase activity of myosin and that the exte. 2010. Tiago, Teresa; Palma, Pedro; Gutiérrez-Merino, Carlos; Aureliano, M.; Tiago, T.; Palma, P.S.; Gutierrez-Merino, C.. http://hdl.handle.net/10400.1/1362.
    10.3109/10715762.2010.502170
  18. Actin as a potential target for decavanadate. ATP prevents G-actin cysteine oxidation and vanadyl formation specifically induced by decavanadate, suggesting that the oxometalate–protein interaction is affected by the nucleotide. The ATP exchange rate is increased by 2-fold due to the presence of decavanadate when compared with control actin (3.1×10-3 s-1), and an apparent dissociation constant (kdapp) of 227.4±25.7 µM and 112.3±8.7 µM was obt. 2010. Ramos, Susana; Moura, José J. G.; Aureliano, M.. http://hdl.handle.net/10400.1/1325.
  19. Decavanadate: a journey in a search of a role. Currently, efforts have been directed towards using decavanadate as a tool for the understanding of several biochemical processes such as muscle contraction, calcium homeostasis, in vivo changes of oxidative stress markers, mitochondrial oxygen consumption, mitochondrial membrane depolarization, actin polymerization and glucose uptake, among others. In addition, studies have been conducted in orde. 2009. Aureliano, M.. http://hdl.handle.net/10400.1/1304.
  20. Decavavanadate (V10 O6-28) and oxovanadates: oxometalates with many biological activities. The decameric vanadate species V10O6 28 , also referred to as decavanadate, impact proteins, lipid structures and cellular function, and show some effects in vivo on oxidative stress processes and other biological properties. The mode of action of decavanadate in many biochemical systems depends, at least in part, on the charge and size of the species and in some cases competes with the simpler ox. 2009. Aureliano, M.; Crans, Debbie C.. http://hdl.handle.net/10400.1/1328.
  21. New insights into mineralogenic effects of vanadate. Vanadium is a transition metal that occurs naturally in a variety of minerals and exhibits an exceptional complex chemistry in solution, e.g., several oxidation states ranging from ?2 to ?5, and formation of vanadium oligomers such as decameric vanadate (?5) species [1–4]. Besides its metallurgical role in steel alloys, vanadium is also an ultra trace element known to participate in many biologica. 2009. Laizé, Vincent; Tiago, Daniel M.; Aureliano, M.; Cancela, Leonor; Laizé, V.; Tiago, D.M.; Cancela, M.L.. http://hdl.handle.net/10400.1/1360.
    10.1007/s00018-009-0137-9
  22. Decavanadate interactions with actin: cysteine oxidation and vanadyl formation. Incubation of actin with decavanadate induces cysteine oxidation and oxidovanadium(IV) formation. The studies were performed combining kinetic with spectroscopic (NMR and EPR) methodologies. Although decavanadate is converted to labile oxovanadates, the rate of deoligomerization can be very slow (half-life time of 5.4 h, at 25 ¿C, with a first order kinetics), which effectively allows decavanadate. 2009. Ramos, Susana; Duarte, Rui O.; Moura, José J. G.; Aureliano, M.. http://hdl.handle.net/10400.1/1357.
  23. Effects of decavanadate and insulin enhancing vanadium compounds on glucose uptake in isolated rat adipocytes. The effects of different vanadium compounds namely pyridine-2,6-dicarboxylatedioxovanadium(V) (V5-dipic), bis(maltolato) oxovanadium(IV) (BMOV) and amavadine, and oligovanadates namely metavanadate and decavanadate were analysed on basal and insulin stimulated glucose uptake in rat adipocytes. Decavanadate (50 lM), manifest a higher increases (6-fold) on glucose uptake compared with basal, followe. 2009. Pereira, Maria João; Carvalho, Eugénia; Eriksson, Jan W.; Crans, Debbie C.; Aureliano, M.; Pereira, M.J.; Carvalho, E.; Eriksson, J.W.; Crans, D.C.. http://hdl.handle.net/10400.1/1324.
    10.1016/j.jinorgbio.2009.09.015
  24. Sarcoplasmic reticulum calcium ATPase is inhibited by organic vanadium coordination compounds: pyridine-2-6-dicarboxylatodioxovanadium(V), BMOV and an amavadine analogue. The general affinity of the sarcoplasmic reticulum (SR) Ca2+-ATPase was examined for three different classes of vanadium coordination complexes including a vanadium(V) compound, pyridine-2,6-dicarboxylatodioxovanadium(V) (PDC-V(V)), and two vanadium(IV) compounds, bis(maltolato)oxovanadium(IV) (BMOV), and an analogue of amavadine, bis(N-hydroxylamidoiminodiacetato)vanadium(IV) (HAIDA-V(IV)). The a. 2008. Aureliano, M.; Henao, Fernando; Tiago, Teresa; Duarte, Rui O.; Moura, José J. G.; Baruah, Bharat; Crans, Debbie C.; et al. http://hdl.handle.net/10400.1/1321.
    10.1021/ic702405d
  25. Vanadium and cadmium in vivo effects in cardiac muscle: metal accumulation and oxidative stress markers. Several biological studies associate vanadium and cadmium with the production of reactive oxygen species (ROS), leading to lipid peroxidation and antioxidant enzymes alterations. The present study aims to analyse and compare the oxidative stress responses induced by an acute intravenous exposure (1 and 7 days) to a sub-lethal concentration (5 mM) of two vanadium solutions, containing different van. 2008. Soares, S. S.; Martins, H.; Gutiérrez-Merino, Carlos; Aureliano, M.. http://hdl.handle.net/10400.1/1294.
  26. Biological Effects of Decavanadate: Muscle Contraction, In Vivo Oxidative Stress, and Mitochondrial Toxicity. 2007. Manuel Aureliano; Sandra S. Soares; Teresa Tiago; Susana Ramos; Carlos Gutiérrez-Merino. https://doi.org/10.1021%2Fbk-2007-0974.ch018.
    10.1021/bk-2007-0974.ch018
  27. Decavanadate induces mitochondrial membrane depolarization and inhibits oxygen consumption. Decavanadate induced rat liver mitochondrial depolarization at very low concentrations, half-depolarization with 39 nM decavanadate, while it was needed a 130-fold higher concentration of monomeric vanadate (5 lM) to induce the same effect. Decavanadate also inhibits mitochondrial repolarization induced by reduced glutathione in vitro, with an inhibition constant of 1 lM, whereas no effect was obs. 2007. Soares, S. S.; Gutiérrez-Merino, Carlos; Aureliano, M.; Soares, S.S.; Gutiérrez-Merino, C.. http://hdl.handle.net/10400.1/1297.
    10.1016/j.jinorgbio.2007.01.012
  28. Binding modes of decavanadate to myosin and inhibition of the actomyosin ATPase activity. Decavanadate, a vanadate oligomer, is known to interact with myosin and to inhibit the ATPase activity, but the putative binding sites and the mechanism of inhibition are still to be clarified. We have previously proposed that the decavanadate (V10O28 6-) inhibition of the actin-stimulated myosin ATPase activity is non-competitive towards both actin and ATP. A likely explanation for these results. 2007. Tiago, Teresa; Martel, Paulo; Gutiérrez-Merino, Carlos; Aureliano, M.; Gutierrez-Merino, Carlos; Aureliano, Manuel. http://hdl.handle.net/10400.1/1298.
    10.1016/j.bbapap.2007.02.004
  29. Peroxynitrite induces F-actin depolymerization and blockade of myosin ATPase stimulation. Treatment of F-actin with the peroxynitrite-releasing agent 3-morpholinosydnonimine (SIN-1) produced a dose-dependent F-actin depolymerization. This is due to released peroxynitrite because it is not produced by ‘decomposed SIN-1’, and it is prevented by superoxide dismutase concentrations efficiently preventing peroxynitrite formation. F-actin depolymerization has been found to be very sensitive. 2006. Tiago, Teresa; Ramos, Susana; Aureliano, M.; Gutiérrez-Merino, Carlos; Tiago, T; Ramos, S; Aureliano, M; Gutierrez-Merino, C. http://hdl.handle.net/10400.1/1292.
    10.1016/j.bbrc.2006.01.112
  30. Decavanadate interactions with actin: inhibition of G-actin polymerization and stabilization of decameric vanadate. Decameric vanadate species (V10) inhibit the rate and the extent of G-actin polymerization with an IC50 of 68 ± 22 lM and 17 ± 2 lM, respectively, whilst they induce F-actin depolymerization at a lower extent. On contrary, no effect on actin polymerization and depolymerization was detected for 2 mM concentration of ‘‘metavanadate’’ solution that contains ortho and metavanadate species, as observed. 2006. Ramos, Susana; Manuel, Miguel; Tiago, Teresa; Duarte, Rui O.; Martins, Jorge; Gutiérrez-Merino, Carlos; Moura, José J. G.; Aureliano, M.. http://hdl.handle.net/10400.1/1293.
    10.1016/j.jinorgbio.2006.06.007
  31. Vanadium distribution following decavanadate administration. An acute exposure of two vanadate solutions— metavanadate and decavanadate—containing different vanadate oligomers, induces different patterns of subcellular vanadium distribution in blood plasma, red blood cells (RBC), and cardiac muscle subcellular fractions of the fish Sparus aurata (gilthead seabream). The highest amount of vanadium was found in blood plasma 1 h after (5 mM) intravenous vanada. 2006. Soares, S. S.; Martins, H.; Aureliano, M.; Soares, SS; Martins, H; Aureliano, M. http://hdl.handle.net/10400.1/1319.
    10.1007/s00244-004-0246-2
  32. Decavanadate effects in biological systems. Vanadium biological studies often disregarded the formation of decameric vanadate species known to interact, in vitro, with high-affinity with many proteins such as myosin and sarcoplasmic reticulum calcium pump and also to inhibit these biochemical systems involved in energy transduction. Moreover, very few in vivo animal studies involving vanadium consider the contribution of decavanadate to van. 2005. Aureliano, M.; Gândara, Ricardo M. C.. http://hdl.handle.net/10400.1/1290.
    10.1016/j.jinorgbio.2005.02.024
  33. Vanadate oligomers: in vivo effects in hepatic vanadium accumulation and stress markers. The formation of vanadate oligomeric species is often disregarded in studies on vanadate effects in biological systems, particularly in vivo, even though they may interact with high affinity with many proteins. We report the effects in fish hepatic tissue of an acute intravenous exposure (12, 24 h and 7 days) to two vanadium(V) solutions, metavanadate and decavanadate, containing different vanadat. 2005. Gândara, Ricardo M. C.; Soares, S. S.; Martins, H.; Gutiérrez-Merino, Carlos; Aureliano, M.. http://hdl.handle.net/10400.1/1295.
  34. O conceito de cientista em diferentes níveis de ensino. O ensino das ciências experimentais envolve um grande empenho, além de um consumo de tempo elevado, da parte dos professores para promover e induzir uma aprendizagem dinâmica de diversos conceitos científicos. Neste trabalho, é analisado o conceito de cientista no ensino básico e universitário. O presente estudo, relativo ao ano lectivo 2004 / 05, envolveu cerca de 600 alunos do ensino básico, des. 2005. Lima, Ana M. S.; Neves, Margarida R.; Cordeiro, Clara; Aureliano, M.. http://hdl.handle.net/10400.1/1305.
  35. Decavanadate as a biochemical tool in the elucidation of muscle contraction regulation. Recently reported decameric vanadate (V10) high affinity binding site in myosin S1, suggests that it can be used as a tool in the muscle contraction regulation. In the present article, it is shown that V10 species induces myosin S1 cleavage, upon irradiation, at the 23 and 74 kDa sites, the latter being prevented by actin and the former blocked by the presence of ATP. Identical cleavage patterns w. 2004. Tiago, Teresa; Aureliano, M.; Moura, José J. G.; Tiago, T.; Moura, J.J.G.. http://hdl.handle.net/10400.1/1289.
    10.1016/j.jinorgbio.2004.08.013
  36. Quenching of myosin intrinsic fluorescence unravels the existence of a high affinity binding site for decavanadate. Decavanadate, one of the aggregated species of vanadate, is a potent inhibitor of several enzymes, includingskeletalmusclemyosin.However,itsputativebindingsitesinmyosinarelargelyunknown. Titration of the intrinsic fluorescence of myosin, purified from rabbit skeletal muscle, have been carried out in 0.3 M KCl, 5 mM CaCl2 and 25 mM Tris-HCl (pH 7.0), with 0.1 mg/ml myosin. In the 0–200¿M total vana. 2002. Aureliano, M.. http://hdl.handle.net/10400.1/4809.
  37. Vanadate oligomers interactions with myosin. ‘Monovanadate’containingamixtureofatleastfourdifferentvanadatespeciesand‘decavanadate’containingapparentlyonlytwovanadate species, mainly decameric species, inhibit myosin and actomyosin ATPase activities. The addition of myosin to ‘monovanadate’ and ‘decavanadate’solutionspromotesdifferentialincreasesonthe 51VNMRspectrallinewidthsofvanadateoligomers.Therelativeorderofline broadening upon myosin a. 2000. Aureliano, M.. http://hdl.handle.net/10400.1/4775.
    http://dx.doi.org/ 10.1016/S0162-0134(00)00021-0
  38. Vanadate oligomer inhibition of passive and active Ca2+ translocation by the Ca2+ pump of sarcoplasmic reticulum. ‘Monovanadate’ containing mainly monomeric, dimeric and tetrameric vanadate species or ‘decavanadate’, containingmainlydecameric vanadate species inhibits the passive and the active ef¿ux of Ca2+ through the sarcoplasmic reticulum calcium pump. When the ef¿ux of Ca2+ by sarcoplasmic reticulum vesicles is not associated with ATP synthesis both vanadate solutions inhibit the passive ef¿ux of Ca 2+.. 2000. Aureliano, M.; Manuel Aureliano. http://hdl.handle.net/10400.1/4776.
    10.1016/s0162-0134(00)00022-2
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/10/15 Polyoxovanadates biological activities: the present comes from the future! Manuel Aureliano, Universidade do Algarve, V12 Vanadium Symposium
Cyprus
2020 Aplicaçoes biológicas de polioxometalatos Departamento de Química
Universidade Nova de Lisboa (Caparica, Portugal)
2019 35 anos a dançar com o decavanadato: interação com proteínas versus estudos in vivo e in vitro! XX anos do curso de Bioquímica, 2019
Uni Evora (Évora, Portugal)
2019 Polyoxovanadates with antibacterial activity: Are P-type ATPases the only target? ICBIC-19 19th International Conference on Biological Inorganic Chemistry 2019
(Interlaken, Switzerland)
2019 Polyoxotungstates with anticancer activity: Are membrane proteins attractive targets? 10th Meeting on Signal transduction - Sinal 2019
(Olhão, Portugal)
2019 Proposed mechanisms of the anticancer activity of polyoxometalates 10th Meeting on Signal transduction - Sinal 2019
(Olhão, Portugal)
2018 Os cursos de Bioquímica em Portugal XXV Aniversário do Curso de Bioquímica no Algarve
(Faro, Portugal)
2018 Thirty years of dancing with decavanadate: From chemistry to “in vivo” studies! 11th International Vanadium Symposium
(Montevideo, Uruguay)
2018 Vanadium applications, toxicity mechanisms and allergic reactions VIII Workshop em Bioquímica Clínica
(Évora, Portugal)
2018 Recent Insights Into the Biological Activities of Polyoxometalates 24th IUPAC International Conference on Physical Organic Chemistry
Universidade do Algarve (Faro, Portugal)
2017 "30th years of dancing with decavanadate” Part I: Interactions with proteins Fakultät für Chemie, Institut für Biophysikalische Chemie
Universität Wien (Viena, Austria)
2017 "30th years of dancing with decavanadate” Part II: In vivo and in vitro studies Fakultät für Chemie, Institut für Biophysikalische Chemie
Universität Wien (Viena, Austria)
2017 New insights into protein interactions of decavanadate Department of Inorganic Chemistry
University of Bratislava (Bratislava, Slovakia)
2017 A brief overview of the Biochemistry degrees in Portugal Meeting of Coordinators of Bachelor and Master degrees in Biochemistry, FEBS3+
(Barcelona, Spain)
2017 New insights into actin interactions of decavanadate: CD Spectroscopic Studies 2nd International Caparica Christmas Congress on Translational Chemistry
(Caparica, Portugal)
2017 POMs as inhibitors of P-type ATPases and the role of polyphenols 11th World Congress on Polyphenols Applications
(Viena, Austria)
2016 Celebrating Decavanadate (V10) at the 10th International Vanadium Symposium The 10th International Vanadium Symposium
(Taiwan)
2016 Isostructural decavanadate and decaniobate decompose into different oligomers: biochemical relevance 1º Encontro Nacional de Bioinorgânica
(Sintra, Portugal)

Journal scientific committee

Journal title (ISSN) Publisher
2018/01/01 - 2018/12/31 Metallomics
2017/01/01 - 2017/12/31 Metallomics
Distinctions

Other distinction

2023 World¿s Top 2% Scientists ranking: ano de 2022
2023 World¿s Top 2% Scientists ranking; ao longo da carreira; ano 2022
2022 World¿s Top 2% Scientists ranking: ano de 2021
2021 World’s Top 2% Scientists ranking; ao longo da carreira
2021 World’s Top 2% Scientists ranking: ano de 2020
2019 Top reviewers in Molecular Biology and Genetics - September 2019
2019 Publons, Top reviewers in Biology and Biochemistry - September 2019
2019 Publons, Top reviewers in Cross-Field - September 2019
2019 Metallomics, Outstanding reviewer, top 10, 2019
2018 Top reviewers for Chemistry - September 2018
2018 Top reviewers for Biology And Biochemistry - September 2018
2018 Metallomics, Outstanding reviewer, top 10, 2018
2017 Metallomics, Outstanding reviewer, top 10, 2017