Joaquim Manuel Sampaio Cabral (AB13-9ED3-C821)

Curriculum Vitae

Joaquim Manuel Sampaio Cabral

Joaquim M S Cabral is Distinguished Full Professor of Instituto Superior Técnico (IST), University of Lisbon, Portugal. He was the Founding Head (2011) of Department of Bioengineering and the Founding Director (2013) of the Institute for Bioengineering and Biosciences at IST. UNIVERSITY EDUCATION AND FACULTY POSITIONS: Diploma in Chemical Engineering (1976), PhD (1982) and Habilitation (1988) from IST. Post-doctoral study at Massachusetts Institute of Technology (1983-4); faculty positions: Assistant (1983-6), Associate (1986-91) and Full Professor (1992). He was the first Distinguished Professor (2015) at IST. RESEARCH INTERESTS AND OUTPUTS: Joaquim Cabral has authored more than 600 original research articles, review articles, book chapters and books in biotechnology and bioprocess engineering with higher than 14 thousand citations (WoS h index 57). His lab-Stem Cell Engineering Research Group- is focused on cell production platforms for the ex-vivo expansion of stem cells and/or their controlled differentiation into specific cell types and micro-tissues, as well as their integration with bioseparation and high-resolution purification technologies. The goal is to generate large numbers of specific and high quality stem/progenitor cell subsets needed for Regenerative Medicine settings as well as to develop in vitro models for disease modelling and drug testing. His lab has established an international track record in Stem Cell Engineering, as assessed by WTEC, on behalf of NSF, NIST and NIH (The International Assessment of Research in Biological Engineering and Manufacturing 2015; The International Assessment of R&D in Stem Cell Engineering 2013). LEARNING AND SCIENTIFIC SOCIETIES: Joaquim Cabral is Member of the Portuguese Academy of Engineering (1999-); Corresponding Member of the Lisbon Academy of Sciences (2015-); a Founding Member of Sociedade Portuguesa de Biotecnologia (1981) and President (1987-92); Founding Member of Sociedade Portuguesa de Células Estaminais e Terapia Celular (2005), Vice-President (2006), President (2009-10); Member of the European Federation of Biotechnology (EFB) Section on Applied Biocatalysis (1985-), Chairman (1990-5) and Honorary Member (2005-); Member of the Executive Committee of the EFB Section on Biochemical Engineering Science (1999-2004) and Chairman of its Task Group on Biotransformation (1996-2004); Member of the Steering Committee of the Process Integration in Biochemical Engineering Programme of the European Science Foundation (1992-6); Member of the Executive Committee of the European Biochemical Engineering Network (1993-6); Founding Member (2013) of the European Society of Biochemical Engineering Science and chair of the Regenerative Medicine Manufacturing Section; Member of the Scientific Board of the Tissue Engineering and Regenerative Medicine International Society Thematic Group on Bioreactor Technologies (2013). ADVISORY AND EVALUATION COMMITTEES: Joaquim Cabral has been serving several scientific committees. European Commission: Portuguese Delegate of the Biotechnology Framework Programme IV (1994-8) and Member of the Product and Process Engineering Evaluation Panel of the European Research Council¿Advanced Grants (2009-14); ANR-French National Research Agency; Biotechnology and Biological Sciences, Medical and Engineering and Physical Sciences Research Councils, UK; Member of the Biotechnology Strategy Group of the European Academies¿ Science Advisory Council, The Royal Society (2002-2006); President of the Scientific Council of Exact and Engineering Sciences of the Portuguese Fundação para a Ciência e a Tecnologia (2010¿2013). Coordinator of the Peer Review Committee of the Biotechnology and Biological Engineering Research Grants of the Portuguese Fundação para a Ciência e a Tecnologia (2007-2013); Member (2014-2020) of the Amgen Bioprocessing Center Advisory Board at Keck Graduate Institute, School of Applied Life Sciences, Claremont, California, USA.

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Identification

Personal identification

Full name: Joaquim Manuel Sampaio Cabral

Citation names

Cabral, Joaquim
Joaquim M.S. Cabral
J.M.S. Cabral

Author identifiers

Ciência ID: AB13-9ED3-C821
ORCID iD: 0000-0002-2405-5845

Telephones

Telephone

218419063 (Professional)

Addresses

Instuto Superior Técnico, Av Rovisco Pais, 1049-001, Lisboa, Lisboa, Portugal (Professional)

Websites

http://scerg.tecnico.ulisboa.pt/jmscabral.html (Scholar)

Knowledge fields

Engineering and Technology - Industrial Biotechnology
Medical and Health Sciences - Medical Biotechnology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
French	Upper intermediate (B2)	Upper intermediate (B2)	Upper intermediate (B2)	Upper intermediate (B2)	Upper intermediate (B2)
Spanish; Castilian	Elementary (A2)	Upper intermediate (B2)	Elementary (A2)	Upper intermediate (B2)	Upper intermediate (B2)

Education

	Degree	Classification
1988/11/02 Concluded	Engenharia Química (Título de Agregado) Universidade de Lisboa Instituto Superior Técnico, Portugal	Aprovado por Unanimidade
1983/09/01 - 1984/10/01 Concluded	Engenharia Bioquímica (Pós-doutoramento) Massachusetts Institute of Technology, United States
1978/12/10 - 1983/01/07 Concluded	Engenharia Química (Doutoramento) Instituto Superior Técnico, Universidade de Lisboa, Portugal	Aprovado por Unanimidade com Distinção e Louver
1970/10/01 - 1976/03 Concluded	Engenharia Química (Licenciatura) Instituto Superior Técnico, Universidade de Lisboa, Portugal	16 valores

Affiliation

Science

	Category Host institution	Employer
1992/02/01 - Current	Coordinating Researcher (Research)	Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
	Universidade de Lisboa Instituto Superior Técnico, Portugal

Teaching in Higher Education

	Category Host institution	Employer
1992/02/01 - Current	Full Professor (University Teacher)	Instituto Superior Técnico, Universidade de Lisboa, Portugal
	Instituto Superior Técnico, Universidade de Lisboa, Portugal
1987/02/01 - 1992/01	Associate Professor (University Teacher)	Instituto Superior Técnico, Universidade de Lisboa, Portugal
	Instituto Superior Técnico, Universidade de Lisboa, Portugal
1983/01/08 - 1987/01/31	Assistant Professor (University Teacher)	Instituto Superior Técnico, Universidade de Lisboa, Portugal
	Instituto Superior Técnico, Universidade de Lisboa, Portugal

Positions / Appointments

	Category Host institution	Employer
2021/01/01 - 2022/12/31	Director	Universidade de Lisboa Instituto Superior Técnico, Portugal
	Laboratório Associado Instituto para a Saúde e a Bioeconomia, Portugal

Others

	Category Host institution	Employer
2000/01/01 - Current	Coordinating Researcher Stem Cell Engineering Research Group	Instituto Superior Técnico, Universidade de Lisboa, Portugal
	Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Projects

Grant

	Designation	Funders
2015/01 - 2017/12	Institute for Bioengineering and Biosciences grant.Provided by PTCRIS: 147338	Fundação para a Ciência e a Tecnologia
2014/12 - 2017/11	CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications grant.Provided by PTCRIS: 137185	Fundação para a Ciência e a Tecnologia
2013/03 - 2016/02	Induction of Immune Tolerance in Human Allogeneic Hematopoietic Stem Cell Transplantation 123713 Provided by PTCRIS: 123713	Fundação para a Ciência e a Tecnologia, I.P.
2014/01 - 2015/12	Incentive - LA 23 - 2014 grant.Provided by PTCRIS: 137340	Fundação para a Ciência e a Tecnologia
2014/04 - 2015/03	CARDIOSAFER -Safety and efficacy of intracoronary mesenchymal stem/stromal cell (MSC)-based therapy for myocardial regeneration: a microcirculation study Provided by PTCRIS: 134995 134995	Fundação para a Ciência e a Tecnologia, I.P.
2014/01 - 2014/12	Bioengineering the Neural Commitment of Human Pluripotent Stem Cells: Rational Approaches for the Clinical-Grade Production of Neuronal Cells 133316 Provided by PTCRIS: 133316	Fundação para a Ciência e a Tecnologia, I.P.
2012/01 - 2014/12	StemPure - Bioprocess for Production and Purification of Human Pluripotent Stem Cell-derived Neural Cells for Regenerative Medicine Applications Provided by PTCRIS: 122504 122504	Fundação para a Ciência e a Tecnologia, I.P.
2011/01 - 2013/12	Scalable Reactor Systems for the Production of Human Mesenchymal Stem Cells 114231 Provided by PTCRIS: 114231	Fundação para a Ciência e a Tecnologia, I.P.
2010/04 - 2013/09	StemCellQCM - Acoutic detectors for stem cell adhesion and differentiation 105189 Provided by PTCRIS: 105189	Fundação para a Ciência e a Tecnologia, I.P.
2010/01 - 2012/12	Exploring human embryonic stem cell fate using 3-D cellular microarrays 101088 Provided by PTCRIS: 101088	Fundação para a Ciência e a Tecnologia, I.P.
2010/01 - 2012/12	Integrated Process for the Expansion and Neural Differentiation of Human Embryonic Stem Cells in Stirred Suspension Bioreactors 105277 Provided by PTCRIS: 105277	Fundação para a Ciência e a Tecnologia, I.P.
2010/01 - 2012/12	STEMSELECT - Novel integrated process for human hematopoietic stem cell isolation and ex-vivo expansion Provided by PTCRIS: 104663 104663	Fundação para a Ciência e a Tecnologia, I.P.
2009/01 - 2012/06	Sol-gel entrapped cutinase: Understanding enzyme/matrix interactions via fluorescence, NMR and DRIFT spectroscopies, and site-directed mutagenesis 64744 Provided by PTCRIS: 64744	Fundação para a Ciência e a Tecnologia, I.P.
2009/08 - 2011/07	Integrated Lab On Chip Platforms for Medical Diagnostics Provided by PTCRIS: 109367 109367	Fundação para a Ciência e a Tecnologia, I.P.
2007/10 - 2010/12	Biological and Molecular Characterization of Avian Influenza Viruses and Development of DIVA Tests 67189 Provided by PTCRIS: 67189	Fundação para a Ciência e a Tecnologia, I.P.
2007/10 - 2010/10	STEM CELL LAB ON CHIP: MAGNETIC CELL SEPARATOR AND DISCRIMINATOR PLATFORMS Provided by PTCRIS: 68617 68617	Fundação para a Ciência e a Tecnologia, I.P.
2007/01 - 2008/12	Rationalization of cutinase enantioselectivity in nonaqueous media 82386 Provided by PTCRIS: 82386	Fundação para a Ciência e a Tecnologia, I.P.
2007/01 - 2008/09	Friction and wear mechanisms in orthopaedic prostheses: influence of the composition of the periprosthetic fluid. Provided by PTCRIS: 82512 82512	Fundação para a Ciência e a Tecnologia, I.P.
2005/06 - 2007/12	Rationalization of cutinase enantioselectivity in nonaqueous media 57193 Provided by PTCRIS: 57193	Fundação para a Ciência e a Tecnologia, I.P.
2005/04 - 2007/12	Friction and wear mechanisms in orthopaedic prostheses: influence of the composition of the periprosthetic fluid. 55493 Provided by PTCRIS: 55493	Fundação para a Ciência e a Tecnologia, I.P.

Contract

	Designation	Funders
2020/01/01 - Current	Institute for Bioengineering and Biosciences UIDB/04565//2020 + UIDP/04565/2020 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Ongoing
2021/01/01 - 2025/12/31	Institute for Health and Bioeconomy LA/P/0140/2020 10.54499/LA/P/0140/2020 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Universidade Nova de Lisboa, Portugal INESC Microsistemas e Nanotecnologias, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/04/01 - 2025/03/31	AMELIE: Anchored Muscle cELls for IncontinencE 874807 - AMELIE Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2021/03/01 - 2025/02/28	Exploiting the power of decellularized extracellular matrix to fabricate hierarchical biomimetic scaffolds to regenerate functional periodontal tissues<br> PTDC/BTM-MAT/3538/2020 10.54499/PTDC/BTM-MAT/3538/2020 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Universidade Católica Portuguesa Centro de Estudos de Gestão e Economia, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/02/01 - 2025/01/31	New technologies for Stem cell Manufacturing bioprocess monitoring and ARTificial intelligence-based modeling PTDC/EQU-EQU/3853/2020 10.54499/PTDC/EQU-EQU/3853/2020 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Instituto de Telecomunicações Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/01 - 2024/12/31	Quality by design-centered platform for the manufacturing of CAR-engineered NK cells and extracellular vesicles for immunotherapy PTDC/EQU-EQU/3708/2021 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/01 - 2024/12/31	Quality by design-centered platform for the manufacturing of CAR-engineered NK cells and extracellular vesicles for immunotherapy PTDC/EQU-EQU/3708/2021 10.54499/PTDC/EQU-EQU/3708/2021 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/01/01 - 2024/12/31	Institute for Bioengineering and Biosciences UIDP/04565/2020 10.54499/UIDP/04565/2020 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/01/01 - 2024/12/31	Institute for Bioengineering and Biosciences UIDB/04565/2020 10.54499/UIDB/04565/2020 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2023/02/15 - 2024/08/14	Engineering an innervated heart organoid – the initial step for in vitro modulation of neuro-cardiac cross-talk 2022.02251.PTDC Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2023/02/15 - 2024/08/14	Engineering an innervated heart organoid – the initial step for in vitro modulation of neuro-cardiac cross-talk 2022.02251.PTDC 10.54499/2022.02251.PTDC Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/03/01 - 2024/02/29	Exploiting the power of decellularized extracellular matrix to fabricate hierarchical biomimetic scaffolds to regenerate functional periodontal tissues<br> PTDC/BTM-MAT/3538/2020 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/02/01 - 2024/01/31	New technologies for Stem cell Manufacturing bioprocess monitoring and ARTificial intelligence-based modeling PTDC/EQU-EQU/3853/2020 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Instituto de Telecomunicações Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/10/01 - 2022/09/30	Organoid Engineering for Production of 3D Cardiovascular Microtissues from Human Induced Pluripotent Stem Cells for Cardiotoxicity Assays PTDC/EMD-TLM/29728/2017 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/10/01 - 2022/09/30	Upscaling the Production of Human Pluripotent Stem Cell-derived Cardiomyocytes using Vertical-Wheel Bioreactors PTDC/EQU-EQU/29653/2017 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/10/01 - 2022/09/30	Organoid Engineering for Production of 3D Cardiovascular Microtissues from Human Induced Pluripotent Stem Cells for Cardiotoxicity Assays PTDC/EMD-TLM/29728/2017 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/10/01 - 2022/09/30	Upscaling the Production of Human Pluripotent Stem Cell-derived Cardiomyocytes using Vertical-Wheel Bioreactors PTDC/EQU-EQU/29653/2017 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/10/01 - 2022/06/30	Development of a scalable manufacturing process for therapeutic human mesenchymal stem/stromal cell-derived exosomes PTDC/EQU-EQU/31651/2017 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/06/01 - 2021/05/31	CEREBEX Generation of Cerebellar Organoids for Ataxia Research LISBOA-01-0145-FEDER-029298 Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Ongoing
2018/06/01 - 2021/05/31	Generation of gene-edited cerebellar organoids for ataxia research PTDC/BTM-SAL/29298/2017 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/06 - 2021/05	CEREBEX Generation of Cerebellar Organoids for Ataxia Research LISBOA-01-0145-FEDER-029298	Fundação para a Ciência e a Tecnologia
2016/12/01 - 2020/11/30	PRECISE: Accelerating progress toward the new era of precision medicine SAICTPAC/0021/2015 - LISBOA-01-0145-FEDER-016394 Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Ongoing
2019/01/01 - 2019/12/31	Institute for Bioengineering and Biosciences IBB 2019 - UID/BIO/04565/2019 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia, I.P.
2019/01/01 - 2019/12/31	Institute for Bioengineering and Biosciences UID/BIO/04565/2019 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016/04/01 - 2019/03/31	Design and operation of a prototype packed-bed reactor for the production of hematopoietic stem/progenitor cells PTDC/QEQ-EPR/6623/2014 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/01/01 - 2018/12/31	Institute for Bioengineering and Biosciences IBB 2019 - UID/BIO/04565/2019 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Concluded
2015/01/01 - 2018/12/31	Institute for Bioengineering and Biosciences UID/BIO/04565/2013 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2014/12/01 - 2018/05/31	CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications MITP-TB/ECE/0013/2013 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal University of Minnesota Twin Cities Department of Medicine, United States Instituto de Biologia Experimental e Tecnológica, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/03/01 - 2016/08/31	Induction of Immune Tolerance in Human Allogeneic Hematopoietic Stem Cell Transplantation HMSP-ICT/0001/2011 Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2014/01/01 - 2015/12/31	Incentive - LA 23 - 2014 Incentivo/EQB/LA0023/2014 Instituto de Biotecnologia e Bioengenharia, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Fundação Gaspar Frutuoso, Portugal Universidade do Minho, Portugal Universidade do Algarve, Portugal Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal Universidade de Trás-os-Montes e Alto Douro, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2014/04/01 - 2015/09/30	CARDIOSAFER -Safety and efficacy of intracoronary mesenchymal stem/stromal cell (MSC)-based therapy for myocardial regeneration: a microcirculation study EXPL/BIM-MED/1970/2013 Instituto de Biotecnologia e Bioengenharia, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal University of Minnesota Twin Cities Department of Medicine, United States	Fundação para a Ciência e a Tecnologia Concluded
2014/01/01 - 2014/12/31	Bioengineering the Neural Commitment of Human Pluripotent Stem Cells: Rational Approaches for the Clinical-Grade Production of Neuronal Cells EXPL/BBB-EBI/0294/2013 Instituto de Biotecnologia e Bioengenharia, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/01/01 - 2014/12/31	Strategic Project - LA 23 - 2013-2014 PEst-OE/EQB/LA0023/2013 Instituto de Biotecnologia e Bioengenharia, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Fundação Gaspar Frutuoso, Portugal Universidade do Minho, Portugal Universidade do Algarve, Portugal Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal Universidade de Trás-os-Montes e Alto Douro, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/01/01 - 2014/12/31	StemPure - Bioprocess for Production and Purification of Human Pluripotent Stem Cell-derived Neural Cells for Regenerative Medicine Applications PTDC/EBB-BIO/122504/2010 Instituto de Biotecnologia e Bioengenharia, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/01/01 - 2013/12/31	Incentive - LA 23 - 2013 Incentivo/EQB/LA0023/2013 Instituto de Biotecnologia e Bioengenharia, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Fundação Gaspar Frutuoso, Portugal Universidade do Minho, Portugal Universidade do Algarve, Portugal Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal Universidade de Trás-os-Montes e Alto Douro, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/02 - 2013/12/31	Scalable Reactor Systems for the Production of Human Mesenchymal Stem Cells PTDC/EQU-EQU/114231/2009 Universidade de Lisboa Instituto Superior Técnico, Portugal Instituto de Biotecnologia e Bioengenharia, Portugal Instituto Português do Sangue e da Transplantação IP, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/04/01 - 2013/09/30	StemCellQCM - Acoutic detectors for stem cell adhesion and differentiation PTDC/SAU-BEB/105189/2008 Instituto de Biotecnologia e Bioengenharia, Portugal Universidade do Algarve, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2012/12/31	Strategic Project - LA 23 - 2011-2012 PEst-OE/EQB/LA0023/2011 Instituto de Biotecnologia e Bioengenharia, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal Fundação Gaspar Frutuoso, Portugal Universidade do Minho, Portugal Universidade do Algarve, Portugal Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal Universidade de Trás-os-Montes e Alto Douro, Portugal Universidade dos Açores, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01/01 - 2012/12/31	Exploring human embryonic stem cell fate using 3-D cellular microarrays PTDC/EBB-BIO/101088/2008 Universidade de Lisboa Instituto Superior Técnico, Portugal Instituto de Biotecnologia e Bioengenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01/01 - 2012/12/31	Integrated Process for the Expansion and Neural Differentiation of Human Embryonic Stem Cells in Stirred Suspension Bioreactors PTDC/EQU-ERQ/105277/2008 Universidade de Lisboa Instituto Superior Técnico, Portugal Instituto de Biotecnologia e Bioengenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01/01 - 2012/12/31	STEMSELECT - Novel integrated process for human hematopoietic stem cell isolation and ex-vivo expansion PTDC/EQU-EPR/104663/2008 Universidade de Lisboa Instituto Superior Técnico, Portugal Instituto de Biotecnologia e Bioengenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/01/01 - 2012/06/30	Sol-gel entrapped cutinase: Understanding enzyme/matrix interactions via fluorescence, NMR and DRIFT spectroscopies, and site-directed mutagenesis PTDC/QUI/64744/2006 Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/08/01 - 2011/07/31	Integrated Lab On Chip Platforms for Medical Diagnostics NANO/NMed-SD/0140/2007 INESC Microsistemas e Nanotecnologias, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal Universidade de Aveiro, Portugal Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007/10/01 - 2010/12/31	Biological and Molecular Characterization of Avian Influenza Viruses and Development of DIVA Tests PTDC/CVT/67189/2006 Laboratório Nacional de Investigação Veterinária, Portugal Instituto Nacional de Investigação Agrária e Veterinária, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007/10/15 - 2010/10/14	STEM CELL LAB ON CHIP: MAGNETIC CELL SEPARATOR AND DISCRIMINATOR PLATFORMS PTDC/CTM/68617/2006 INESC Microsistemas e Nanotecnologias, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/06/01 - 2007/12/31	Rationalization of cutinase enantioselectivity in nonaqueous media POCI/BIO/57193/2004 Universidade Católica Portuguesa Portuguesa Centro de Biotecnologia e Química Fina, Portugal Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/04/01 - 2007/12/31	Friction and wear mechanisms in orthopaedic prostheses: influence of the composition of the periprosthetic fluid. POCI/SAU-BMA/55493/2004 Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade de Lisboa Centro de Química Estrutural, Portugal Centro de Apoio Tecnológico à Indústria Metalomecânica, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book	Joaquim M.S. Cabral. Engineering Strategies for Regenerative Medicine. Elsevier. 2019. Published • 10.1016/c2018-0-00059-6 Joaquim M.S. Cabral. Bioreactors for Stem Cell Expansion and Differentitation ISBN 978-1-4987-9590-6. United States: CRC Press. 2018. Editor Joaquim M.S. Cabral. Stem Cell Manufacturing, ISBN 978-0-444-63265-4. Elsevier. 2016. Published • Editor Joaquim M.S. Cabral; Maria Margarida Diogo; Tiago G Fernandes. Stem Cell Bioprocessing: For Cellular Therapy, Diagnostics and Drug Development, ISBN 978-1-907568-88-6. Elsevier. 2014. Published Joaquim M.S. Cabral. Engenharia Enzimática, ISBN: 978-972-757-272-4. 2003. Editor Mota, Manuel; Tramper, Johannes; Cabral, Joaquim M.S.(AB13-9ED3-C821). Multiphase Bioreactor Design, ISBN 0-415-2720-2. Taylor & Francis. 2001. 10.4324/9780203303047 • Editor Joaquim M.S. Cabral. Applied Biocatalysis, ISBN 3-7186-5391-5. Harwood Academic Publishers / Taylor and Francis. 1994. Editor Joaquim M.S. Cabral. Recovery Processes for Biological Materials, ISBN-13: 978-0471933496. John Wiley. 1993. Editor Joaquim M.S. Cabral. Chromatographic and Membrane Processes in Biotechnology, ISBN 13: 978-94-011-3470-5. Netherlands: Springer. 1991. Editor Joaquim M.S. Cabral; Alan Rosevear; John Frederick Kennedy. Immobilized Enzymes and Cells. United States: Adam Hilger. 1987. Published
Book chapter	Joaquim M.S. Cabral; Carlos A.V. Rodrigues. Corresponding author: Carlos A.V. Rodrigues. "3 Salvador, W. O. S., Nogueira, D. E. S., Bovolato, A. L. C., Ferreira, F. C., Cabral, J. M. S., Rodrigues, C. A. V., "Bringing Cellular Agriculture to the Table: The Role of Animal Cell Bioreactors", Cellular Agriculture: Technical and Scientific Foundations (Evan Fraser; David Kaplan; Lenore Newman; Rickey Yada). Elsevier, (2023) 161-175.". 2023. Nogueira, Diogo E. S.; Rodrigues, Carlos A. V.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim M. S.. "Suspension Culture of Human Induced Pluripotent Stem Cells in Single-Use Vertical-Wheel™ Bioreactors Using Aggregate and Microcarrier Culture Systems". In Stem Cells and Good Manufacturing Practices, 167-178. Springer US, 2020. 10.1007/7651_2020_287 Fernandes-Platzgummer, Ana; Andrade, Pedro Z.; Cabral, Joaquim M. S.; da Silva, Cláudia Lobato. "Scalable Manufacturing of Human Hematopoietic Stem/Progenitor Cells Exploiting a Co-culture Platform with Mesenchymal Stromal Cells". In Stem Cells and Good Manufacturing Practices, 107-120. Springer US, 2020. 10.1007/7651_2020_289
Conference paper	Frederico Barbosa; João C. Silva; Fábio F. F. Garrudo; Joaquim M. S. Cabral; Paula Pascoal-Faria; Jorge Morgado; Frederico C. Ferreira. "Fabrication of Novel Electroconductive PAN/PEDOT:PSS Nanofibers for Osteochondral Tissue Regeneration". 2022. 10.3390/materproc2022008117
Journal article	João C. Silva; Pedro Marcelino; João Meneses; Frederico Barbosa; Carla S. Moura; Ana C. Marques; Joaquim M. S. Cabral; et al. "Synergy between 3D-extruded electroconductive scaffolds and electrical stimulation to improve bone tissue engineering strategies". Journal of Materials Chemistry B (2024): https://doi.org/10.1039/D3TB02673F. 10.1039/D3TB02673F Teresa Franchi-Mendes; Marília Silva; Ana Luísa Cartaxo; Ana Fernandes-Platzgummer; Joaquim M. S. Cabral; Cláudia L. da Silva. "Bioprocessing Considerations towards the Manufacturing of Therapeutic Skeletal and Smooth Muscle Cells". Bioengineering (2023): https://doi.org/10.3390/bioengineering10091067. 10.3390/bioengineering10091067 Ana Fernandes-Platzgummer; Raquel Cunha; Sara Morini; Marta Carvalho; Juan Moreno-Cid; Carmen García; Joaquim M. S. Cabral; Cláudia L. da Silva. "Optimized operation of a controlled stirred tank reactor system for the production of mesenchymal stromal cells and their extracellular vesicles". Biotechnology and Bioengineering (2023): https://doi.org/10.1002/bit.28449. 10.1002/bit.28449 Frederico Barbosa; Fábio F. F. Garrudo; Ana C. Marques; Joaquim M. S. Cabral; Jorge Morgado; Frederico Castelo Ferreira; João C. Silva. "Novel Electroactive Mineralized Polyacrylonitrile/PEDOT:PSS Electrospun Nanofibers for Bone Repair Applications". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241713203. 10.3390/ijms241713203 Laura Alves; Vanessa Machado; João Botelho; José João Mendes; Joaquim M. S. Cabral; Cláudia L. da Silva; Marta S. Carvalho. "Enhanced Proliferative and Osteogenic Potential of Periodontal Ligament Stromal Cells". Biomedicines (2023): https://doi.org/10.3390/biomedicines11051352. 10.3390/biomedicines11051352 Mariana A. Branco; Tiago C. Nunes; Joaquim M. S. Cabral; Maria Margarida Diogo. "Developmental Toxicity Studies: The Path towards Humanized 3D Stem Cell-Based Models". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24054857. 10.3390/ijms24054857 J.M.S. Cabral. "Abbasalizadeh, S., Babaee, S., Kowsari-Esfahan, R., Mazidi, Z., Shi, Y., Wainer, J., Cabral, J. M. S., Langer, R., Traverso, G., Baharvand, H., “Continuous Production of Higly Functional Vascularized Hepatobiliary Organoids from Human Pluripotent Stem Cells using a Scalable Microluidic Platform” Advanced Funtional Materials 33(49) (2023). https://doi.org/10.1002/adfm.202210233". (2023): Published J.M.S. Cabral. Corresponding author: J.M.S. Cabral. "Cartaxo, A. L., Fernandes-Platzgummer, A., Rodrigues, C. A. V., da Silva, C. L., Cabral, J. M. S., “Developing a Cell-Microcarrier Tissue-Engineered Product for Muscle Repair Using a Bioreactor System. Tissue Engineering - Part C: Methods, 29(12) (2023) 583–595. https://doi.org/10.1089/ten.tec.2023.0122". (2023): Published Cabral, Joaquim. "Franchi-Mendes, T., Silva, M., Cartaxo, A. L., Cabral, J. M. S., da Silva, C. L., “Bioprocessing Considerations towards the Manufacturing of Therapeutic Skeletal and Smooth Muscle” Bioengineering-Basel, 10(9) (2023) 1067. https://doi.org/ 10.3390/bioengineering10091067". (2023): Published J.M.S. Cabral. "Manjua, A. C., Cabral, J. M. S., Ferreira, F. C., Portugal, C. A. M., Gumuscu, B., “Design of Blood Vessel Models using Magnetic-Responsive Vascular Platforms2. Advanced Materials Technologies, 8(19) (2023) 2300617. https://doi.org. 10.1002/admt.202300617". (2023): Published Cabral, Joaquim. "Salvador, W. O. S., Nogueira, D. E. S., Ferreira, F. C., Cabral, J. M. S., Rodrigues, C.A.V., “BEMSCA: A novel decision support tool applied to the optimal design of a large-scale human induced pluripotent stem cell expansion bioprocess”. Current Research in Biotechnology, 6 (2023) 100163. https://doi.org./ 10.1016/j.crbiot.2023.100163". (2023): Published J.M.S. Cabral. "Tenreiro, M., Branco, M., Cotovio, J. P., Cabral, J. M. S., Fernandes, T. G., Diogo M. M., “Advancing organoid design through co-emergence, assembly, and bioengineering”, Trends Biotech., 41(7) (2023) 923. https://doi.org/ 10.1016/j.tibtech.2022.12.021". (2023): Published André Branco; Ana L. Tiago; Paula Laranjeira; Maria C. Carreira; João C. Milhano; Francisco dos Santos; Joaquim M. S. Cabral; et al. "Hypothermic Preservation of Adipose-Derived Mesenchymal Stromal Cells as a Viable Solution for the Storage and Distribution of Cell Therapy Products". Bioengineering (2022): https://doi.org/10.3390/bioengineering9120805. 10.3390/bioengineering9120805 Tiago P. Dias; Sandra N. Pinto; Sandra Carvalho; Tiago G. Fernandes; Fábio Fernandes; Maria Margarida Diogo; Maria C. Peleteiro; Manuel Prieto; Joaquim M. S. Cabral. "Cost-Effective Mechanical Aggregation of Cardiac Progenitors and Encapsulation in Matrigel Support Self-Organization in a Dynamic Culture Environment". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232415785. 10.3390/ijms232415785 William O. S. Salvador; Inês A. B. Ribeiro; Diogo E. S. Nogueira; Frederico C. Ferreira; Joaquim M. S. Cabral; Carlos A. V. Rodrigues. "Bioprocess Economic Modeling: Decision Support Tools for the Development of Stem Cell Therapy Products". Bioengineering (2022): https://doi.org/10.3390/bioengineering9120791. 10.3390/bioengineering9120791 Tiago P. Dias; Tânia Baltazar; Sandra N. Pinto; Tiago G. Fernandes; Fábio Fernandes; Maria Margarida Diogo; Manuel Prieto; et al. "Xeno-Free Integrated Platform for Robust Production of Cardiomyocyte Sheets from hiPSCs". Stem Cells International 2022 (2022): 1-11. https://doi.org/10.1155/2022/4542719. 10.1155/2022/4542719 Branco, Mariana A.; Dias, Tiago P.; Cabral, Joaquim M. S.; Pinto-do-Ó, Perpetua; Diogo, Maria Margarida. "Human multilineage pro-epicardium/foregut organoids support the development of an epicardium/myocardium organoid". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-34730-7. 10.1038/s41467-022-34730-7 Miguel de Almeida Fuzeta; Pedro P. Gonçalves; Ana Fernandes-Platzgummer; Joaquim M. S. Cabral; Nuno Bernardes; Cláudia L. da Silva. "From Promise to Reality: Bioengineering Strategies to Enhance the Therapeutic Potential of Extracellular Vesicles". Bioengineering (2022): https://doi.org/10.3390/bioengineering9110675. 10.3390/bioengineering9110675 Cláudia C. Miranda; Mariana Ramalho Gomes; Mariana Moço; Joaquim M. S. Cabral; Frederico Castelo Ferreira; Paola Sanjuan-Alberte. "A Concise Review on Electrospun Scaffolds for Kidney Tissue Engineering". Bioengineering (2022): https://doi.org/10.3390/bioengineering9100554. 10.3390/bioengineering9100554 Pedro M. Neto; Diogo E. S. Nogueira; Yas Hashimura; Sunghoon Jung; Bruno Pedras; Mário N. Berberan-Santos; Tiago Palmeira; et al. "Characterization of the Aeration and Hydrodynamics in Vertical-Wheel™ Bioreactors". Bioengineering 9 8 (2022): 386-386. https://doi.org/10.3390/bioengineering9080386. 10.3390/bioengineering9080386 Sanjuan-Alberte, Paola; Whitehead, Charlie; Jones, Joshua N.; Silva, João C.; Carter, Nathan; Kellaway, Simon; Hague, Richard J.M.; et al. "Printing biohybrid materials for bioelectronic cardio-3D-cellular constructs". iScience 25 7 (2022): 104552. http://dx.doi.org/10.1016/j.isci.2022.104552. 10.1016/j.isci.2022.104552 Diana M. C. Marques; João C. Silva; Ana Paula Serro; Joaquim M. S. Cabral; Paola Sanjuan-Alberte; Frederico C. Ferreira. "3D Bioprinting of Novel ¿-Carrageenan Bioinks: An Algae-Derived Polysaccharide". Bioengineering 9 3 (2022): 109-109. https://doi.org/10.3390/bioengineering9030109. 10.3390/bioengineering9030109 Miranda, Cláudia C.; Akenhead, Michael L.; Silva, Teresa P.; Derr, Michael A.; Vemuri, Mohan C.; Cabral, Joaquim M. S.; Fernandes, Tiago G.. "A Dynamic 3D Aggregate-Based System for the Successful Expansion and Neural Induction of Human Pluripotent Stem Cells". Frontiers in Cellular Neuroscience 16 (2022): http://dx.doi.org/10.3389/fncel.2022.838217. 10.3389/fncel.2022.838217 Brian Lee; Sunghoon Jung; Yas Hashimura; Maximilian Lee; Breanna S. Borys; Tiffany Dang; Michael S. Kallos; et al. "Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products". Bioengineering 9 3 (2022): 92. https://doi.org/10.3390/bioengineering9030092. 10.3390/bioengineering9030092 Carvalho, Marta S.; Alves, Laura; Bogalho, Isabel; Cabral, Joaquim M. S.; da Silva, Cláudia L.. "Impact of Donor Age on the Osteogenic Supportive Capacity of Mesenchymal Stromal Cell-Derived Extracellular Matrix". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.747521. 10.3389/fcell.2021.747521 Laura Sordini; João C. Silva; Fábio F. F. Garrudo; Carlos A. V. Rodrigues; Ana C. Marques; Robert J. Linhardt; Joaquim M. S. Cabral; Jorge Morgado; Frederico Castelo Ferreira. "PEDOT:PSS-Coated Polybenzimidazole Electroconductive Nanofibers for Biomedical Applications". Polymers (2021): https://doi.org/10.3390/polym13162786. 10.3390/polym13162786 Sasan Jalili-Firoozinezhad; Cláudia C. Miranda; Joaquim M.S. Cabral. "Modeling the Human Body on Microfluidic Chips". Trends in Biotechnology 39 8 (2021): 838-852. https://doi.org/10.1016/j.tibtech.2021.01.004. 10.1016/j.tibtech.2021.01.004 Joana Serra; Cláudia P. A. Alves; Joaquim M. S. Cabral; Gabriel A. Monteiro; Cláudia L. Silva; Duarte Miguel F. Prazeres. "Minicircle-based expression of vascular endothelial growth factor in mesenchymal stromal cells from diverse human tissues". The Journal of Gene Medicine (2021): https://doi.org/10.1002/jgm.3342. 10.1002/jgm.3342 Bucar, Sara; Branco, André Dargen de Matos; Mata, Márcia F.; Milhano, João Coutinho; Caramalho, Íris; Cabral, Joaquim M. S.; Fernandes-Platzgummer, Ana; da Silva, Cláudia L.. "Influence of the mesenchymal stromal cell source on the hematopoietic supportive capacity of umbilical cord blood-derived CD34+-enriched cells". Stem Cell Research & Therapy 12 1 (2021): http://dx.doi.org/10.1186/s13287-021-02474-8. 10.1186/s13287-021-02474-8 Manjua, Ana C.; Cabral, Joaquim M. S.; Portugal, Carla A. M.; Ferreira, Frederico Castelo. "Magnetic stimulation of the angiogenic potential of mesenchymal stromal cells in vascular tissue engineering". Science and Technology of Advanced Materials 22 1 (2021): 461-480. http://dx.doi.org/10.1080/14686996.2021.1927834. 10.1080/14686996.2021.1927834 Ana Manjua; Joaquim M.S. Cabral; Frederico Castelo Ferreira; Carla A. M. Portugal. "Magnetic Field Dynamic Strategies for the Improved Control of the Angiogenic Effect of Mesenchymal Stromal Cells". Polymers (2021): https://www.mdpi.com/2073-4360/13/11/1883. 10.3390/polym13111883 Silva, Teresa P.; Sousa-Luís, Rui; Fernandes, Tiago G.; Bekman, Evguenia P.; Rodrigues, Carlos A. V.; Vaz, Sandra H.; Moreira, Leonilde M.; et al. "Transcriptome profiling of human pluripotent stem cell-derived cerebellar organoids reveals faster commitment under dynamic conditions". Biotechnology and Bioengineering 118 7 (2021): 2781-2803. http://dx.doi.org/10.1002/bit.27797. 10.1002/bit.27797 Diogo Nogueira; Joaquim M.S. Cabral; Carlos A.V. Rodrigues. "Single-Use Bioreactors for Human Pluripotent and Adult Stem Cells: Towards Regenerative Medicine Applications". Bioengineering (2021): https://www.mdpi.com/2306-5354/8/5/68. 10.3390/bioengineering8050068 Silva, Teresa P.; Pereira, Carolina A.; Raposo, Ana Cláudia; Oliveira, Ana Rita; Arez, Maria; Cabral, Joaquim M.S.; Milagre, Inês; et al. "Generation and characterization of induced pluripotent stem cells heterozygous for the Portuguese BRCA2 founder mutation". Stem Cell Research 53 (2021): 102364. http://dx.doi.org/10.1016/j.scr.2021.102364. 10.1016/j.scr.2021.102364 Ana Rita Gomes; Tiago G. Fernandes; Joaquim M.S. Cabral; MM Diogo. "Modeling Rett Syndrome with Human Pluripotent Stem Cells: Mechanistic Outcomes and Future Clinical Perspectives". International Journal of Molecular Sciences (2021): https://www.mdpi.com/1422-0067/22/7/3751. 10.3390/ijms22073751 Marta Carvalho; Joaquim M.S. Cabral; Deepak Vashishth. "Bone Matrix Non-Collagenous Proteins in Tissue Engineering: Creating New Bone by Mimicking the Extracellular Matrix". Polymers (2021): https://www.mdpi.com/2073-4360/13/7/1095. 10.3390/polym13071095 Garrudo, Fábio F.F.; Mikael, Paiyz E.; Xia, Ke; Silva, João C.; Ouyang, Yilan; Chapman, Caitlyn A.; Hoffman, Pauline R.; et al. "The effect of electrospun scaffolds on the glycosaminoglycan profile of differentiating neural stem cells". Biochimie 182 (2021): 61-72. http://dx.doi.org/10.1016/j.biochi.2021.01.001. 10.1016/j.biochi.2021.01.001 Sordini, Laura; Garrudo, Fábio F. F.; Rodrigues, Carlos A. V.; Linhardt, Robert J.; Cabral, Joaquim M. S.; Ferreira, Frederico Castelo; Morgado, Jorge. "Effect of Electrical Stimulation Conditions on Neural Stem Cells Differentiation on Cross-Linked PEDOT:PSS Films". Frontiers in Bioengineering and Biotechnology 9 (2021): http://dx.doi.org/10.3389/fbioe.2021.591838. 10.3389/fbioe.2021.591838 Costa, Marta H. G.; Serra, Joana; McDevitt, Todd C.; Cabral, Joaquim M. S.; da Silva, Cláudia L.; Ferreira, Frederico Castelo. "Dimethyloxalylglycine, a small molecule, synergistically increases the homing and angiogenic properties of human mesenchymal stromal cells when cultured as 3D spheroids". Biotechnology Journal 16 5 (2021): 2000389. http://dx.doi.org/10.1002/biot.202000389. 10.1002/biot.202000389 Garrudo, Fábio F.F.; Mikael, Paiyz E.; Rodrigues, Carlos A.V.; Udangawa, Ranodhi W.; Paradiso, Patrizia; Chapman, Caitlyn A.; Hoffman, Pauline; et al. "Polyaniline-polycaprolactone fibers for neural applications: Electroconductivity enhanced by pseudo-doping". Materials Science and Engineering: C 120 (2021): 111680. http://dx.doi.org/10.1016/j.msec.2020.111680. 10.1016/j.msec.2020.111680 Fábio F. F. Garrudo; Diogo E. S. Nogueira; Carlos A. V. Rodrigues; Flávio A. Ferreira; Patrizia Paradiso; Rogério Colaço; Ana C. Marques; et al. "Electrical stimulation of neural-differentiating iPSCs on novel coaxial electroconductive nanofibers". Biomaterials Science (2021): https://doi.org/10.1039/D1BM00503K. 10.1039/D1BM00503K Gomes, Ana Rita; Fernandes, Tiago G.; Vaz, Sandra H.; Silva, Teresa P.; Bekman, Evguenia P.; Xapelli, Sara; Duarte, Sofia; et al. "Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.610427. 10.3389/fcell.2020.610427 de Almeida Fuzeta, Miguel; Bernardes, Nuno; Oliveira, Filipa D.; Costa, Ana Catarina; Fernandes-Platzgummer, Ana; Farinha, José Paulo; Rodrigues, Carlos A. V.; et al. "Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.553444. 10.3389/fcell.2020.553444 Amores de Sousa, Miriam C.; Rodrigues, Carlos A. V.; Ferreira, Inês A. F.; Diogo, Maria Margarida; Linhardt, Robert J.; Cabral, Joaquim M. S.; Ferreira, Frederico Castelo. "Functionalization of Electrospun Nanofibers and Fiber Alignment Enhance Neural Stem Cell Proliferation and Neuronal Differentiation". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.580135. 10.3389/fbioe.2020.580135 Pushp, Pallavi; Nogueira, Diogo E. S.; Rodrigues, Carlos A. V.; Ferreira, Frederico C.; Cabral, Joaquim M. S.; Gupta, Mukesh Kumar. "A Concise Review on Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Personalized Regenerative Medicine". Stem Cell Reviews and Reports 17 3 (2020): 748-776. http://dx.doi.org/10.1007/s12015-020-10061-2. 10.1007/s12015-020-10061-2 Branco, André; Bucar, Sara; Moura-Sampaio, Jorge; Lilaia, Carla; Cabral, Joaquim M. S.; Fernandes-Platzgummer, Ana; Lobato da Silva, Cláudia. "Tailored Cytokine Optimization for ex vivo Culture Platforms Targeting the Expansion of Human Hematopoietic Stem/Progenitor Cells". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.573282. 10.3389/fbioe.2020.573282 Farzaneh, Zahra; Abbasalizadeh, Saeed; Asghari-Vostikolaee, Mohammad-Hassan; Alikhani, Mehdi; Cabral, Joaquim M. S.; Baharvand, Hossein. "Dissolved oxygen concentration regulates human hepatic organoid formation from pluripotent stem cells in a fully controlled bioreactor". Biotechnology and Bioengineering 117 12 (2020): 3739-3756. http://dx.doi.org/10.1002/bit.27521. 10.1002/bit.27521 Mariana A. Branco; Joaquim M.S. Cabral; Maria Margarida Diogo. "From Human Pluripotent Stem Cells to 3D Cardiac Microtissues: Progress, Applications and Challenges". Bioengineering (2020): https://www.mdpi.com/2306-5354/7/3/92. 10.3390/bioengineering7030092 de Sousa Pinto, Diogo; Bandeiras, Cátia; Almeida Fuzeta, Miguel; Rodrigues, Carlos A. V.; Jung, Sunghoon; Hashimura, Yas; Tseng, Rong-Jeng; et al. "Scalable Manufacturing of Human Mesenchymal Stromal Cells in the Vertical-Wheel Bioreactor System: An Experimental and Economic Approach". Biotechnology Journal 15 8 (2020): 2070064. http://dx.doi.org/10.1002/biot.202070064. 10.1002/biot.202070064 Silva, Teresa P.; Fernandes, Tiago G.; Nogueira, Diogo E. S.; Rodrigues, Carlos A. V.; Bekman, Evguenia P.; Hashimura, Yas; Jung, Sunghoon; et al. "Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by Immunostaining". Journal of Visualized Experiments 160 (2020): http://dx.doi.org/10.3791/61143. 10.3791/61143 Moura, Carla Sofia; Silva, João Carlos; Faria, Sofia; Fernandes, Paulo Rui; da Silva, Cláudia Lobato; Cabral, Joaquim Manuel Sampaio; Linhardt, Robert; Bártolo, Paulo Jorge; Ferreira, Frederico Castelo. "Chondrogenic differentiation of mesenchymal stem/stromal cells on 3D porous poly (e-caprolactone) scaffolds: Effects of material alkaline treatment and chondroitin sulfate supplementation". Journal of Bioscience and Bioengineering 129 6 (2020): 756-764. http://dx.doi.org/10.1016/j.jbiosc.2020.01.004. 10.1016/j.jbiosc.2020.01.004 Moreira, Francisco; Mizukami, Amanda; de Souza, Lucas Eduardo Botelho; Cabral, Joaquim M. S.; da Silva, Cláudia L.; Covas, Dimas T.; Swiech, Kamilla. "Successful Use of Human AB Serum to Support the Expansion of Adipose Tissue-Derived Mesenchymal Stem/Stromal Cell in a Microcarrier-Based Platform". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.00307. 10.3389/fbioe.2020.00307 Azevedo, Rita I.; Minskaia, Ekaterina; Fernandes-Platzgummer, Ana; Vieira, Ana I. S.; da Silva, Cláudia L.; Cabral, Joaquim M. S.; Lacerda, João F.. "Mesenchymal stromal cells induce regulatory T cells via epigenetic conversion of human conventional CD4 T cells in vitro". STEM CELLS 38 8 (2020): 1007-1019. http://dx.doi.org/10.1002/stem.3185. 10.1002/stem.3185 Carvalho, Marta S.; Silva, João C.; Hoff, Christopher M.; Cabral, Joaquim M. S.; Linhardt, Robert J.; Silva, Cláudia L.; Vashishth, Deepak. "Loss and rescue of osteocalcin and osteopontin modulate osteogenic and angiogenic features of mesenchymal stem/stromal cells". Journal of Cellular Physiology 235 10 (2020): 7496-7515. http://dx.doi.org/10.1002/jcp.29653. 10.1002/jcp.29653 Brian Lee; Breanna Borys; Michael S. Kallos; Carlos A.V. Rodrigues; Teresa P. Silva; Joaquim M.S. Cabral. "Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products". Bioengineering (2020): https://www.mdpi.com/2306-5354/7/2/31. 10.3390/bioengineering7020031 Silva, João C.; Han, Xiaorui; Silva, Teresa P.; Xia, Ke; Mikael, Paiyz E.; Cabral, Joaquim M. S.; Ferreira, Frederico Castelo; Linhardt, Robert J.. "Glycosaminoglycan remodeling during chondrogenic differentiation of human bone marrow-/synovial-derived mesenchymal stem/stromal cells under normoxia and hypoxia". Glycoconjugate Journal (2020): http://dx.doi.org/10.1007/s10719-020-09911-5. 10.1007/s10719-020-09911-5 Silva, Teresa P.; Bekman, Evguenia P.; Fernandes, Tiago G.; Vaz, Sandra H.; Rodrigues, Carlos A. V.; Diogo, Maria Margarida; Cabral, Joaquim M. S.; Carmo-Fonseca, Maria. "Maturation of Human Pluripotent Stem Cell-Derived Cerebellar Neurons in the Absence of Co-culture". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.00070. 10.3389/fbioe.2020.00070 Silva, João C.; Udangawa, Ranodhi N.; Chen, Jianle; Mancinelli, Chiara D.; Garrudo, Fábio F.F.; Mikael, Paiyz E.; Cabral, Joaquim M.S.; Ferreira, Frederico Castelo; Linhardt, Robert J.. "Kartogenin-loaded coaxial PGS/PCL aligned nanofibers for cartilage tissue engineering". Materials Science and Engineering: C 107 (2020): 110291. http://dx.doi.org/10.1016/j.msec.2019.110291. 10.1016/j.msec.2019.110291 Silva, João C.; Carvalho, Marta S.; Udangawa, Ranodhi N.; Moura, Carla S.; Cabral, Joaquim M. S.; L. da Silva, Cláudia; Ferreira, Frederico Castelo; Vashishth, Deepak; Linhardt, Robert J.. "Extracellular matrix decorated polycaprolactone scaffolds for improved mesenchymal stem/stromal cell osteogenesis towards a patient-tailored bone tissue engineering approach". Journal of Biomedical Materials Research Part B: Applied Biomaterials (2020): http://dx.doi.org/10.1002/jbm.b.34554. 10.1002/jbm.b.34554 Silva, João C.; Moura, Carla S.; Borrecho, Gonçalo; Alves de Matos, António P.; Cabral, Joaquim M. S.; Linhardt, Robert J.; Ferreira, Frederico Castelo. "Effects of glycosaminoglycan supplementation in the chondrogenic differentiation of bone marrow- and synovial- derived mesenchymal stem/stromal cells on 3D-extruded poly (e-caprolactone) scaffolds". International Journal of Polymeric Materials and Polymeric Biomaterials 70 3 (2020): 207-222. http://dx.doi.org/10.1080/00914037.2019.1706511. 10.1080/00914037.2019.1706511 Garrudo, F.F.F.; Udangawa, R.N.; Hoffman, P.R.; Sordini, L.; Chapman, C.A.; Mikael, P.E.; Ferreira, F.A.; et al. "Polybenzimidazole nanofibers for neural stem cell culture". Materials Today Chemistry 14 (2019): 100185. http://dx.doi.org/10.1016/j.mtchem.2019.08.004. 10.1016/j.mtchem.2019.08.004 Pushp, Pallavi; Sahoo, Bijayalaxmi; Ferreira, Frederico C.; Sampaio Cabral, Joaquim M.; Fernandes-Platzgummer, Ana; Gupta, Mukesh K.. "Functional comparison of beating cardiomyocytes differentiated from umbilical cord-derived mesenchymal/stromal stem cells and human foreskin-derived induced pluripotent stem cells". Journal of Biomedical Materials Research Part A 108 3 (2019): 496-514. http://dx.doi.org/10.1002/jbm.a.36831. 10.1002/jbm.a.36831 Silva, João C.; Moura, Carla S.; Borrecho, Gonçalo; Matos, António P. Alves; da Silva, Cláudia L.; Cabral, Joaquim M. S.; Bártolo, Paulo J.; Linhardt, Robert J.; Ferreira, Frederico Castelo. "Extruded Bioreactor Perfusion Culture Supports the Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells in 3D Porous Poly(¿-Caprolactone) Scaffolds". Biotechnology Journal 15 2 (2019): 1900078. http://dx.doi.org/10.1002/biot.201900078. 10.1002/biot.201900078 Nogueira, Diogo E. S.; Rodrigues, Carlos A. V.; Carvalho, Marta S.; Miranda, Cláudia C.; Hashimura, Yas; Jung, Sunghoon; Lee, Brian; Cabral, Joaquim M. S.. "Strategies for the expansion of human induced pluripotent stem cells as aggregates in single-use Vertical-Wheel™ bioreactors". Journal of Biological Engineering 13 1 (2019): http://dx.doi.org/10.1186/s13036-019-0204-1. 10.1186/s13036-019-0204-1 Dias, Tiago P.; Fernandes, Tiago G.; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Multifactorial Modeling Reveals a Dominant Role of Wnt Signaling in Lineage Commitment of Human Pluripotent Stem Cells". Bioengineering 6 3 (2019): 71. http://dx.doi.org/10.3390/bioengineering6030071. 10.3390/bioengineering6030071 Bandeiras, Cátia; Hwa, Albert J.; Cabral, Joaquim M. S.; Ferreira, Frederico Castelo; Finkelstein, Stan N.; Gabbay, Robert A.. "Economics of Beta-Cell Replacement Therapy". Current Diabetes Reports 19 9 (2019): http://dx.doi.org/10.1007/s11892-019-1203-9. 10.1007/s11892-019-1203-9 Garrudo, Fábio F.F.; Chapman, Caitlyn A.; Hoffman, Pauline R.; Udangawa, Ranodhi W.; Silva, João C.; Mikael, Paiyz E.; Rodrigues, Carlos A.V.; et al. "Polyaniline-polycaprolactone blended nanofibers for neural cell culture". European Polymer Journal 117 (2019): 28-37. http://dx.doi.org/10.1016/j.eurpolymj.2019.04.048. 10.1016/j.eurpolymj.2019.04.048 Carvalho, Marta S.; Silva, João C.; Cabral, Joaquim M.S.; Silva, Cláudia L.; Vashishth, Deepak. "Cultured cell-derived extracellular matrices to enhance the osteogenic differentiation and angiogenic properties of human mesenchymal stem/stromal cells". Journal of Tissue Engineering and Regenerative Medicine 13 9 (2019): 1544-1558. http://dx.doi.org/10.1002/term.2907. 10.1002/term.2907 Bandeiras, Cátia; Cabral, Joaquim M. S.; Gabbay, Robert A.; Finkelstein, Stan N.; Ferreira, Frederico Castelo. "Bringing Stem Cell-Based Therapies for Type 1 Diabetes to the Clinic: Early Insights from Bioprocess Economics and Cost-Effectiveness Analysis". Biotechnology Journal 14 8 (2019): 1800563. http://dx.doi.org/10.1002/biot.201800563. 10.1002/biot.201800563 Branco, Mariana A.; Cotovio, João P.; Rodrigues, Carlos A. V.; Vaz, Sandra H.; Fernandes, Tiago G.; Moreira, Leonilde M.; Cabral, Joaquim M. S.; Diogo, Maria Margarida. "Transcriptomic analysis of 3D Cardiac Differentiation of Human Induced Pluripotent Stem Cells Reveals Faster Cardiomyocyte Maturation Compared to 2D Culture". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-45047-9. 10.1038/s41598-019-45047-9 Jalili-Firoozinezhad, Sasan; Gazzaniga, Francesca S.; Calamari, Elizabeth L.; Camacho, Diogo M.; Fadel, Cicely W.; Bein, Amir; Swenor, Ben; et al. "Author Correction: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip". Nature Biomedical Engineering 3 7 (2019): 583-583. http://dx.doi.org/10.1038/s41551-019-0428-x. 10.1038/s41551-019-0428-x Carvalho, Marta S.; Silva, João C.; Udangawa, Ranodhi N.; Cabral, Joaquim M.S.; Ferreira, Frederico Castelo; da Silva, Cláudia L.; Linhardt, Robert J.; Vashishth, Deepak. "Co-culture cell-derived extracellular matrix loaded electrospun microfibrous scaffolds for bone tissue engineering". Materials Science and Engineering: C 99 (2019): 479-490. http://dx.doi.org/10.1016/j.msec.2019.01.127. 10.1016/j.msec.2019.01.127 Pinto, Diogo; Bandeiras, Cátia; Fuzeta, Miguel; Rodrigues, Carlos A. V.; Jung, Sunghoon; Hashimura, Yas; Tseng, Rong-Jeng; et al. "Scalable Manufacturing of Human Mesenchymal Stromal Cells in the Vertical-Wheel Bioreactor System: An Experimental and Economic Approach". Biotechnology Journal 14 8 (2019): 1800716. http://dx.doi.org/10.1002/biot.201800716. 10.1002/biot.201800716 Jalili-Firoozinezhad, Sasan; Gazzaniga, Francesca S.; Calamari, Elizabeth L.; Camacho, Diogo M.; Fadel, Cicely W.; Bein, Amir; Swenor, Ben; et al. "A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip". Nature Biomedical Engineering 3 7 (2019): 520-531. http://dx.doi.org/10.1038/s41551-019-0397-0. 10.1038/s41551-019-0397-0 Silva, Teresa P.; Cotovio, João P.; Bekman, Evguenia; Carmo-Fonseca, Maria; Cabral, Joaquim M. S.; Fernandes, Tiago G.. "Design Principles for Pluripotent Stem Cell-Derived Organoid Engineering". Stem Cells International 2019 (2019): 1-17. http://dx.doi.org/10.1155/2019/4508470. Published • 10.1155/2019/4508470 Silva, João C.; Carvalho, Marta S.; Han, Xiaorui; Xia, Ke; Mikael, Paiyz E.; Cabral, Joaquim M. S.; Ferreira, Frederico Castelo; Linhardt, Robert J.. "Compositional and structural analysis of glycosaminoglycans in cell-derived extracellular matrices". Glycoconjugate Journal 36 2 (2019): 141-154. http://dx.doi.org/10.1007/s10719-019-09858-2. 10.1007/s10719-019-09858-2 Gomes-Silva, Diogo; Atilla, Erden; Atilla, Pinar Ataca; Mo, Feiyan; Tashiro, Haruko; Srinivasan, Madhuwanti; Lulla, Premal; et al. "CD7 CAR T Cells for the Therapy of Acute Myeloid Leukemia". Molecular Therapy 27 1 (2019): 272-280. http://dx.doi.org/10.1016/j.ymthe.2018.10.001. 10.1016/j.ymthe.2018.10.001 Ferro, Tiago; Santhagunam, Aruna; Madeira, Catarina; Salgueiro, Joao B.; da Silva, Claudia L.; Cabral, Joaquim M. S.. "Successful isolation and ex vivo expansion of human mesenchymal stem/stromal cells obtained from different synovial tissue-derived (biopsy) samples". Journal of Cellular Physiology 234 4 (2019): 3973-3984. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000457613700068&KeyUID=WOS:000457613700068. 10.1002/jcp.27202 Rodrigues, André L.; Rodrigues, Carlos A. V.; Gomes, Ana R.; Vieira, Sara F.; Badenes, Sara M.; Diogo, Maria M.; Cabral, Joaquim M.S.. "Dissolvable Microcarriers Allow Scalable Expansion And Harvesting Of Human Induced Pluripotent Stem Cells Under Xeno-Free Conditions". Biotechnology Journal 14 4 (2018): 1800461. http://dx.doi.org/10.1002/biot.201800461. 10.1002/biot.201800461 Carvalho, Marta S; Cabral, Joaquim MS; da Silva, Cláudia L; Vashishth, Deepak. "Synergistic effect of extracellularly supplemented osteopontin and osteocalcin on stem cell proliferation, osteogenic differentiation, and angiogenic properties". Journal of Cellular Biochemistry 120 4 (2018): 6555-6569. http://dx.doi.org/10.1002/jcb.27948. 10.1002/jcb.27948 Miranda, Claudia C.; Fernandes, Tiago G.; Pinto, Sandra N.; Prieto, Manuel; Margarida Diogo, M.; Cabral, Joaquim M. S.. "A scale out approach towards neural induction of human induced pluripotent stem cells for neurodevelopmental toxicity studies". Toxicology Letters 294 (2018): 51-60. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000436612900007&KeyUID=WOS:000436612900007. 10.1016/j.toxlet.2018.05.018 Bandeiras, Catia; Cabral, Joaquim M. S.; Finkelstein, Stan N.; Ferreira, Frederico Castelo. "Modeling biological and economic uncertainty on cell therapy manufacturing: the choice of culture media supplementation". Regenerative Medicine 13 8 (2018): 917-933. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000453002200005&KeyUID=WOS:000453002200005. 10.2217/rme-2018-0034 Jalili-Firoozinezhad, Sasan; Prantil-Baun, Rachelle; Jiang, Amanda; Potla, Ratnakar; Mammoto, Tadanori; Weaver, James C.; Ferrante, Thomas C.; et al. "Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip". Cell Death & Disease 9 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000427410000004&KeyUID=WOS:000427410000004. 10.1038/s41419-018-0304-8 Costa, Marta H. G.; de Soure, Antonio M.; Cabral, Joaquim M. S.; Ferreira, Frederico Castelo; da Silva, Claudia L.. "Hematopoietic Niche - Exploring Biomimetic Cues to Improve the Functionality of Hematopoietic Stem/Progenitor Cells". Biotechnology Journal 13 2 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000424099500003&KeyUID=WOS:000424099500003. 10.1002/biot.201700088 Mizukami, Amanda; de Abreu Neto, Mario Soares; Moreira, Francisco; Fernandes-Platzgummer, Ana; Huang, Yi-Feng; Milligan, William; Cabral, Joaquim M. S.; et al. "A Fully-Closed and Automated Hollow Fiber Bioreactor for Clinical-Grade Manufacturing of Human Mesenchymal Stem/Stromal Cells". Stem Cell Reviews and Reports 14 1 (2018): 141-143. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000424277300012&KeyUID=WOS:000424277300012. 10.1007/s12015-017-9787-4 Cabral, Joaquim M. S.; Palecek, Sean P.. "Regenerative Medicine Manufacturing". Biotechnology Journal 13 2 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000424099500020&KeyUID=WOS:000424099500020. 10.1002/biot.201800026 Serra, Joana; Alves, Claudia P. A.; Brito, Liliana; Monteiro, Gabriel A.; Cabral, Joaquim M. S.; Prazeres, Duarte Miguel F.; da Silva, Claudia L.. "Engineering of Human Mesenchymal Stem/Stromal Cells with Vascular Endothelial Growth Factor-Encoding Minicircles for Angiogenic Ex Vivo Gene Therapy". Human Gene Therapy (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000449926200001&KeyUID=WOS:000449926200001. 10.1089/hum.2018.154 Costa, Marta H. G.; McDevitt, Todd C.; Cabral, Joaquim M. S.; da Silva, Claudia L.; Ferreira, Frederico Castelo. "Tridimensional configurations of human mesenchymal stem/stromal cells to enhance cell paracrine potential towards wound healing processes". Journal of Biotechnology 262 (2017): 28-39. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000413587300003&KeyUID=WOS:000413587300003. 10.1016/j.jbiotec.2017.09.020 Badenes, Sara M.; Fernandes, Tiago G.; Miranda, Claudia C.; Pusch-Klein, Annette; Haupt, Simone; Rodrigues, Carlos A. V.; Diogo, Maria Margarida; Bruestle, Oliver; Cabral, Joaquim M. S.. "Long-term expansion of human induced pluripotent stem cells in amicrocarrier-based dynamic system". Journal of Chemical Technology and Biotechnology 92 3 (2017): 482-493. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000397400500004&KeyUID=WOS:000397400500004. 10.1002/jctb.5074 Simoes, Irina N.; Vale, Paulo; Soker, Shay; Atala, Anthony; Keller, Daniel; Noiva, Rute; Carvalho, Sandra; et al. "Acellular Urethra Bioscaffold: Decellularization of Whole Urethras for Tissue Engineering Applications". Scientific Reports 7 (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000393369600001&KeyUID=WOS:000393369600001. 10.1038/srep41934 Pushp, Pallavi; Ferreira, Frederico Castelo; Sampaio Cabral, Joaquim M.; Gupta, Mukesh Kumar. "Improved Survival of Cardiac Cells on Surface Modified Electrospun Nanofibers". Polymer Science Series A 59 4 (2017): 515-523. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000406314600006&KeyUID=WOS:000406314600006. 10.1134/s0965545x17040058 Rodrigues, Goncalo M. C.; Gaj, Thomas; Adil, Maroof M.; Wahba, Joyce; Rao, Antara T.; Lorbeer, Franziska K.; Kulkarni, Rishi U.; et al. "Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System". Stem Cell Reports 8 6 (2017): 1770-1783. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000402964700028&KeyUID=WOS:000402964700028. 10.1016/j.stemcr.2017.04.027 Rodrigues, Carlos J. C.; Pereira, Ricardo F. S.; Fernandes, Pedro; Cabral, Joaquim M. S.; de Carvalho, Carla C. C. R.. "Cultivation-based strategies to find efficient marine biocatalysts". Biotechnology Journal 12 7 (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000404888200019&KeyUID=WOS:000404888200019. 10.1002/biot.201700036 Gomes-Silva, Diogo; Mukherjee, Malini; Srinivasan, Madhuwanti; Krenciute, Giedre; Dakhova, Olga; Zheng, Yueting; Cabral, Joaquim M. S.; et al. "Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent". Cell Reports 21 1 (2017): 17-26. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000412111000003&KeyUID=WOS:000412111000003. 10.1016/j.celrep.2017.09.015 de Soure, Antonio M.; Fernandes-Platzgummer, Ana; Moreira, Francisco; Lilaia, Carla; Liu, Shi-Hwei; Ku, Chen-Peng; Huang, Yi-Feng; et al. "Integrated culture platform based on a human platelet lysate supplement for the isolation and scalable manufacturing of umbilical cord matrix-derived mesenchymal stem/stromal cells". Journal of Tissue Engineering and Regenerative Medicine 11 5 (2017): 1630-1640. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000402987500029&KeyUID=WOS:000402987500029. 10.1002/term.2200 Abbasalizadeh, Saeed; Pakzad, Mohammad; Cabral, Joaquim M. S.; Baharvand, Hossein. "Allogeneic cell therapy manufacturing: process development technologies and facility design options". Expert Opinion on Biological Therapy 17 10 (2017): 1201-1219. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000409205800003&KeyUID=WOS:000409205800003. 10.1080/14712598.2017.1354982 Miranda, Claudia C.; Fernandes, Tiago G.; Margarida Diogo, M.; Cabral, Joaquim M. S.. "Scaling up a chemically-defined aggregate-based suspension culture system for neural commitment of human pluripotent stem cells". Biotechnology Journal 11 12 (2016): 1628-1638. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000390700800015&KeyUID=WOS:000390700800015. 10.1002/biot.201600446 Mizukami, A.; Fernandes-Platzgummer, A.; Carmelo, J. G.; Swiech, K.; Covas, D. T.; Cabral, J. M. S.; da Silva, C. L.. "Stirred tank bioreactor culture combined with serum-/xenogeneic-free culture medium enables an efficient expansion of umbilical cord-derived mesenchymal stem/stromal cells". Biotechnology Journal 11 8 (2016): 1048-1059. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000381071900007&KeyUID=WOS:000381071900007. 10.1002/biot.201500532 de Soure, A. M.; Fernandes-Platzgummer, A.; da Silva, C. L.; Cabral, J. M. S.. "Scalable microcarrier-based manufacturing of mesenchymal stem/stromal cells". Journal of Biotechnology 236 (2016): 88-109. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000384852600010&KeyUID=WOS:000384852600010. 10.1016/j.jbiotec.2016.08.007 Badenes, S. M.; Fernandes, T. G.; Rodrigues, C. A. V.; Diogo, M. M.; Cabral, J. M. S.. 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M.; Boucher, Shayne; Kuninger, David; Vemuri, Mohan C.; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Defined Essential 8 (TM) Medium and Vitronectin Efficiently Support Scalable Xeno-Free Expansion of Human Induced Pluripotent Stem Cells in Stirred Microcarrier Culture Systems". Plos One 11 3 (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000372694700028&KeyUID=WOS:000372694700028. 10.1371/journal.pone.0151264 Hatami, Javad; Andrade, Pedro Z.; Alves de Matos, Antonio Pedro; Djokovic, Dusan; Lilaia, Carla; Ferreira, Frederico Castelo; Cabral, Joaquim M. S.; da Silva, Claudia L.. "Developing a co-culture system for effective megakaryo/thrombopoiesis from umbilical cord blood hematopoietic stem/progenitor cells". 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"A value-added exopolysaccharide as a coating agent for MRI nanoprobes". Nanoscale 7 34 (2015): 14272-14283. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000360117200011&KeyUID=WOS:000360117200011. 10.1039/c5nr01979f Fiarresga, Antonio; Mata, Marcia F.; Cavaco-Goncalves, Sandra; Selas, Mafalda; Simoes, Irina N.; Oliveira, Eunice; Carrapico, Belmira; et al. "Intracoronary Delivery of Human Mesenchymal/Stromal Stem Cells: Insights from Coronary Microcirculation Invasive Assessment in a Swine Model". Plos One 10 10 (2015): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000363026600004&KeyUID=WOS:000363026600004. 10.1371/journal.pone.0139870 Andrade, Pedro Z.; de Soure, Antonio M.; dos Santos, Francisco; Paiva, Artur; Cabral, Joaquim M. S.; da Silva, Claudia L.. 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Journal of Tissue Engineering and Regenerative Medicine (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875833797&partnerID=MN8TOARS. 10.1002/term.1741 Ribeiro, A.; Laranjeira, P.; Mendes, S.; Velada, I.; Leite, C.; Andrade, P.; Santos, F.; et al. "Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells". Stem Cell Research & Therapy 4 (2013): 16-16. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000329182800001&KeyUID=WOS:000329182800001. 10.1186/scrt336 Aguiar-Oliveira, E.; Fernandes, P.; Cabral, J. M. S.; Maugeri, F.. "Characterisation of biocatalysts immobilised in niobium-a new inorganic solid support". Canadian Journal of Chemical Engineering 91 3 (2013): 432-440. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000314655600004&KeyUID=WOS:000314655600004. 10.1002/cjce.21653 Rodrigues, G.M.C.; Matos, A.F.S.; Fernandes, T.G.; Rodrigues, C.A.V.; Peitz, M.; Haupt, S.; Diogo, M.M.; Brüstle, O.; Cabral, J.M.S.. "Integrated Platform for Production and Purification of Human Pluripotent Stem Cell-Derived Neural Precursors". Stem Cell Reviews and Reports (2013): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887169214&partnerID=MN8TOARS. 10.1007/s12015-013-9482-z Dos Santos, F.F.; Andrade, P.Z.; Da Silva, C.L.; Cabral, J.M.S.. "Bioreactor design for clinical-grade expansion of stem cells". Biotechnology Journal 8 6 (2013): 644-654. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878966849&partnerID=MN8TOARS. 10.1002/biot.201200373 Moreira, F.; Badenes, S.M.; Cabral, J.M.S.. "Biocatalytic transesterification of triglycerides and alcohols for the production of biodiesel using cutinase in organic media". Biocatalysis and Biotransformation 31 5 (2013): 246-254. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885902578&partnerID=MN8TOARS. 10.3109/10242422.2013.836800 Boura, J.S.; Santos, F.D.; Gimble, J.M.; Cardoso, C.M.P.; Madeira, C.; Cabral, J.M.S.; Silva, C.L.D.. "Direct head-to-head comparison of cationic liposome-mediated gene delivery to mesenchymal stem/stromal cells of different human sources: A comprehensive study". Human Gene Therapy Methods 24 1 (2013): 38-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878329812&partnerID=MN8TOARS. 10.1089/hgtb.2012.185 Badenes, S.M.; Ferreira, F.C.; Cabral, J.M.S.. "Membrane Bioreactors for Biofuel Production". Separation and Purification Technologies in Biorefineries (2013): 377-407. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886971369&partnerID=MN8TOARS. 10.1002/9781118493441.ch14 Oliveira, P.H.; Lobato da Silva, C.; Cabral, J.M.S.. "An Appraisal of Human Mitochondrial DNA Instability: New Insights into the Role of Non-Canonical DNA Structures and Sequence Motifs". PLoS ONE 8 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875515679&partnerID=MN8TOARS. 10.1371/journal.pone.0059907 Simões, I.N.; Boura, J.S.; Dos Santos, F.; Andrade, P.Z.; Cardoso, C.M.P.; Gimble, J.M.; Da Silva, C.L.; Cabral, J.M.S.. "Human mesenchymal stem cells from the umbilical cord matrix: Successful isolation and ex vivo expansion using serum-/xeno-free culture media". Biotechnology Journal 8 4 (2013): 448-458. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875805805&partnerID=MN8TOARS. 10.1002/biot.201200340 Gracio, Filipe; Cabral, Joaquim; Tidor, Bruce. "Modeling Stem Cell Induction Processes". Plos One 8 5 (2013): 10.1371/journal.pone.0060240 Oliveira, P.H.; Boura, J.S.; Abecasis, M.M.; Gimble, J.M.; da Silva, C.L.; Cabral, J.M.S.. "Impact of hypoxia and long-term cultivation on the genomic stability and mitochondrial performance of ex vivo expanded human stem/stromal cells". Stem Cell Research 9 3 (2012): 225-236. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864954257&partnerID=MN8TOARS. 10.1016/j.scr.2012.07.001 Coelho, M.B.; Cabral, J.M.S.; Karp, J.M.. "Intraoperative stem cell therapy". Annual Review of Biomedical Engineering 14 (2012): 325-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864207517&partnerID=MN8TOARS. 10.1146/annurev-bioeng-071811-150041 Diogo, M.M.; da Silva, C.L.; Cabral, J.M.S.. "Separation technologies for stem cell bioprocessing". Biotechnology and Bioengineering 109 11 (2012): 2699-2709. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866748912&partnerID=MN8TOARS. 10.1002/bit.24706 Santhagunam, A.; Madeira, C.; Cabral, J.M.S.. "Genetically engineered stem cell-based strategies for articular cartilage regeneration". Biotechnology and Applied Biochemistry 59 2 (2012): 121-131. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859909109&partnerID=MN8TOARS. 10.1002/bab.1016 Ribeiro, S.; Mairhofer, J.; Madeira, C.; Diogo, M.M.; Lobato Da Silva, C.; Monteiro, G.; Grabherr, R.; Cabral, J.M.. "Plasmid DNA size does affect nonviral gene delivery efficiency in stem cells". Cellular Reprogramming 14 2 (2012): 130-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859514561&partnerID=MN8TOARS. 10.1089/cell.2011.0093 Marques, M.P.C.; Fernandes, P.; Cabral, J.M.S.; Žnidaršic-Plazl, P.; Plazl, I.. "Continuous steroid biotransformations in microchannel reactors". New Biotechnology 29 2 (2012): 227-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855801679&partnerID=MN8TOARS. 10.1016/j.nbt.2011.10.001 Madeira, A.; da Silva, C.L.; dos Santos, F.; Camafeita, E.; Cabral, J.M.S.; Sá-Correia, I.. "Human mesenchymal stem cell expression program upon extended ex-vivo cultivation, as revealed by 2-de-based quantitative proteomics". PLoS ONE 7 8 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84865185516&partnerID=MN8TOARS. 10.1371/journal.pone.0043523 de Barros, D.P.C.; Azevedo, A.M.; Cabral, J.M.S.; Fonseca, L.P.. "Optimization Of Flavor Esters Synthesis By Fusarium Solani Pisi Cutinase". Journal of Food Biochemistry 36 3 (2012): 275-284. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861819057&partnerID=MN8TOARS. 10.1111/j.1745-4514.2010.00535.x Barbosa, H.S.C.; Fernandes, T.G.; Dias, T.P.; Diogo, M.M.; Cabral, J.M.S.. 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"Effect of hypoxia on proliferation and neural commitment of embryonic stem cells at different stages of pluripotency". 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053955908&partnerID=MN8TOARS. 10.1109/ENBENG.2011.6026039 Da Silva, C.L.; Andrade, P.Z.; Dos Santos, F.; Cabral, J.M.S.. "Ex-vivo expansion of hematopoietic stem cells from umbilical cord blood". 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053965018&partnerID=MN8TOARS. 10.1109/ENBENG.2011.6026052 Rodrigues, C.A.V.; Diogo, M.M.; Da Silva, C.L.; Cabral, J.M.S.. "Microcarrier expansion of mouse embryonic stem cell-derived neural stem cells in stirred bioreactors". Biotechnology and Applied Biochemistry 58 4 (2011): 231-242. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051763713&partnerID=MN8TOARS. 10.1002/bab.37 Badenes, S.M.; Lemos, F.; Cabral, J.M.. "Performance of a cutinase membrane reactor for the production of biodiesel in organic media". Biotechnology and Bioengineering 108 6 (2011): 1279-1289. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954527079&partnerID=MN8TOARS. 10.1002/bit.23054 dos Santos, F.; Andrade, P.Z.; Eibes, G.; da Silva, C.L.; Cabral, J.M.. "Ex vivo expansion of human mesenchymal stem cells on microcarriers.". Methods in molecular biology (Clifton, N.J.) 698 (2011): 189-198. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959788681&partnerID=MN8TOARS. 10.1007/978-1-60761-999-4_15 Fernandes-Platzgummer, A.; Diogo, M.M.; Da Silva, C.L.; Cabral, J.M.S.. "Large-scale expansion of mouse embryonic stem cells on microcarriers". Methods in Molecular Biology 690 (2011): 121-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952196818&partnerID=MN8TOARS. 10.1007/978-1-60761-962-8_8 Rodrigues, C.A.V.; Fernandes, T.G.; Diogo, M.M.; da Silva, C.L.; Cabral, J.M.S.. "Stem cell cultivation in bioreactors". Biotechnology Advances 29 6 (2011): 815-829. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053449223&partnerID=MN8TOARS. 10.1016/j.biotechadv.2011.06.009 Oliveira, P.H.; Boura, J.S.; Abecasis, M.M.; Da Silva, C.L.; Cabral, J.M.S.. "An appraisal of genetic stability in human mesenchymal stem cells". 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053975955&partnerID=MN8TOARS. 10.1109/ENBENG.2011.6026040 Rodrigues, C.A.V.; Diogo, M.M.; Da Silva, C.L.; Cabral, J.M.S.. "Design and operation of bioreactor systems for the expansion of pluripotent stem cell-derived neural stem cells". 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053983127&partnerID=MN8TOARS. 10.1109/ENBENG.2011.6026041 Palavra, A.M.F.; Coelho, J.P.; Barroso, J.G.; Rauter, A.P.; Fareleira, J.M.N.A.; Mainar, A.; Urieta, J.S.; et al. "Supercritical carbon dioxide extraction of bioactive compounds from microalgae and volatile oils from aromatic plants". Journal of Supercritical Fluids 60 (2011): 21-27. http://www.scopus.com/inward/record.url?eid=2-s2.0-81355147746&partnerID=MN8TOARS. 10.1016/j.supflu.2011.04.017 Badenes, S.M.; Lemos, F.; Cabral, J.M.S.. "Kinetics and mechanism of the cutinase-catalyzed transesterification of oils in AOT reversed micellar system". Bioprocess and Biosystems Engineering 34 9 (2011): 1133-1142. http://www.scopus.com/inward/record.url?eid=2-s2.0-81755172013&partnerID=MN8TOARS. 10.1007/s00449-011-0564-5 Sousa, A.F.; Andrade, P.Z.; Pirzgalska, R.M.; Galhoz, T.M.; Azevedo, A.M.; da Silva, C.L.; Aires-Barros, M.R.; Cabral, J.M.S.. "A novel method for human hematopoietic stem/progenitor cell isolation from umbilical cord blood based on immunoaffinity aqueous two-phase partitioning". Biotechnology Letters 33 12 (2011): 2373-2377. http://www.scopus.com/inward/record.url?eid=2-s2.0-81155152440&partnerID=MN8TOARS. 10.1007/s10529-011-0727-0 Lourenço, N.M.T.; Österreicher, J.; Cabral, J.M.S.; Fonseca, L.P.; Vidinha, P.; Barreiros, S.. "Evaluation of Ion Jelly biopolymer on glucose biosensing". 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053935230&partnerID=MN8TOARS. 10.1109/ENBENG.2011.6026055 Fernandes, T.G.; Diogo, M.M.; Dordick, J.S.; Cabral, J.M.S.. "Exploring embryonic stem cell fate using cellular microarrays". 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053938598&partnerID=MN8TOARS. 10.1109/ENBENG.2011.6026038 Sousa, A.F.; Loureiro, J.; Diogo, M.M.; Cabral, J.M.S.; Freitas, P.P.. "Magnetic separation of undifferentiated mouse Embryonic Stem (ES) cells from neural progenitor cultures using a microfluidic device". 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053988818&partnerID=MN8TOARS. 10.1109/ENBENG.2011.6026049 Fernandes-Platzgummer, A.; Diogo, M.M.; Baptista, R.P.; Silva, C.L.D.; Cabral, J.M.. "Scale-up of mouse embryonic stem cell expansion in stirred bioreactors". Biotechnology Progress 27 5 (2011): 1421-1432. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053909366&partnerID=MN8TOARS. 10.1002/btpr.658 Loureiro, J.; Andrade, P.Z.; Cardoso, S.; Da Silva, C.L.; Cabral, J.M.; Freitas, P.P.. "Magnetoresistive chip cytometer". Lab on a Chip - Miniaturisation for Chemistry and Biology 11 13 (2011): 2255-2261. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958807569&partnerID=MN8TOARS. 10.1039/c0lc00324g De Barros, D.P.C.; Fernandes, P.; Cabral, J.M.S.; Fonseca, L.P.. "Synthetic application and activity of cutinase in an aqueous, miniemulsion model system: Hexyl octanoate synthesis". Catalysis Today 173 1 (2011): 95-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052267227&partnerID=MN8TOARS. 10.1016/j.cattod.2011.05.039 Madeira, C.; Ribeiro, S.C.; Mendes, R.; Pinheiro, I.S.M.; Da Silva, C.L.; Cabral, J.M.S.. "Genetic engineering of stem cells by non-viral vectors". 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80054006607&partnerID=MN8TOARS. 10.1109/ENBENG.2011.6026044 Loureiro, J.; Andrade, P.Z.; Cardoso, S.; Da Silva, C.L.; Cabral, J.M.; Freitas, P.P.. "Spintronic chip cytometer". Journal of Applied Physics 109 7 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79955422738&partnerID=MN8TOARS. 10.1063/1.3559503 Lourenço, N.M.T.; Österreicher, J.; Vidinha, P.; Barreiros, S.; Afonso, C.A.M.; Cabral, J.M.S.; Fonseca, L.P.. "Effect of gelatin-ionic liquid functional polymers on glucose oxidase and horseradish peroxidase kinetics". Reactive and Functional Polymers 71 4 (2011): 489-495. http://www.scopus.com/inward/record.url?eid=2-s2.0-79751528987&partnerID=MN8TOARS. 10.1016/j.reactfunctpolym.2011.01.006 Badenes, S.M.; Lemos, F.; Cabral, J.M.S.. "Stability of cutinase, wild type and mutants, in AOT reversed micellar system-effect of mixture components of alkyl esters production". Journal of Chemical Technology and Biotechnology 86 1 (2011): 34-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650055584&partnerID=MN8TOARS. 10.1002/jctb.2505 Madeira, C.; Ribeiro, S.C.; Pinheiro, I.S.M.; Martins, S.A.M.; Andrade, P.Z.; da Silva, C.L.; Cabral, J.M.S.. "Gene delivery to human bone marrow mesenchymal stem cells by microporation". Journal of Biotechnology 151 1 (2011): 130-136. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650679233&partnerID=MN8TOARS. 10.1016/j.jbiotec.2010.11.002 Andrade, P.Z.; Lobato Da Silva, C.; Dos Santos, F.; Almeida-Porada, G.; Cabral, J.M.S.. "Initial CD34 + cell-enrichment of cord blood determines hematopoietic stem/progenitor cell yield upon ex vivo expansion". Journal of Cellular Biochemistry 112 7 (2011): 1822-1831. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051484006&partnerID=MN8TOARS. 10.1002/jcb.23099 Andrade, PZ; dos Santos, F; Almeida-Porada, G; da Silva, CL; Cabral, JMS. "Systematic delineation of optimal cytokine concentrations to expand hematopoietic stem/progenitor cells in co-culture with mesenchymal stem cells". Molecular Biosystems 6 7 (2010): 1207-1215. 10.1039/b922637k Fernandes, P.; Cabral, J.M.S.. "Applied Biocatalysis: An Overview". Industrial Biotechnology: Sustainable Growth and Economic Success (2010): 227-250. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869045691&partnerID=MN8TOARS. 10.1002/9783527630233.ch6 Fernandes, T.G.; Kwon, S.-J.; Bale, S.S.; Lee, M.-Y.; Diogo, M.M.; Clark, D.S.; Cabral, J.M.S.; Dordick, J.S.. "Three-dimensional cell culture microarray for high-throughput studies of stem cell fate". Biotechnology and Bioengineering 106 1 (2010): 106-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951583526&partnerID=MN8TOARS. 10.1002/bit.22661 Fernandes, T.G.; Barbosa, H.S.C.; Diogo, M.M.; Cabral, J.M.S.; Dordick, J.S.. "Stem cell microarrays as novel systems for high-throughput screening applications". Bio Tech International 22 2 (2010): 16-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953314506&partnerID=MN8TOARS. Marques, M.P.C.; Cabral, J.M.S.; Fernandes, P.. "A microwell platform for the scale-up of a multistep bioconversion to bench-scale reactors: Sitosterol side-chain cleavage". Biotechnology Journal 5 4 (2010): 402-412. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950639065&partnerID=MN8TOARS. 10.1002/biot.200900098 Madeira, C.; Ribeiro, S.C.; Turk, M.Z.; Cabral, J.M.S.. "Optimization of gene delivery to HEK293T cells by microporation using a central composite design methodology". Biotechnology Letters 32 10 (2010): 1393-1399. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956780502&partnerID=MN8TOARS. 10.1007/s10529-010-0327-4 Marques, M.P.C.; De Carvalho, C.C.C.R.; Cabral, J.M.S.; Fernandes, P.. "Scaling-up of complex whole-cell bioconversions in conventional and non-conventional media". Biotechnology and Bioengineering 106 4 (2010): 619-626. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954268016&partnerID=MN8TOARS. 10.1002/bit.22711 Marques, M.P.C.; Fernandes, P.; Cabral, J.M.S.; Žnidaršic-Plazl, P.; Plazl, I.. "On the feasibility of in situ steroid biotransformation and product recovery in microchannels". Chemical Engineering Journal 160 2 (2010): 708-714. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954818551&partnerID=MN8TOARS. 10.1016/j.cej.2010.03.056 Rodrigues, C.A.V.; Diogo, M.M.; Da Silva, C.L.; Cabral, J.M.S.. "Hypoxia enhances proliferation of mouse embryonic stem cell-derived neural stem cells". Biotechnology and Bioengineering 106 2 (2010): 260-270. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953062351&partnerID=MN8TOARS. 10.1002/bit.22648 Da Silva, C.L.; Gonçalves, R.; Dos Santos, F.; Andrade, P.Z.; Almeida-Porada, G.; Cabral, J.M.S.. "Dynamic cell-cell interactions between cord blood haematopoietic progenitors and the cellular niche are essential for the expansion of CD34 +, CD34+CD38- and early lymphoid CD7 + cells". Journal of Tissue Engineering and Regenerative Medicine 4 2 (2010): 149-158. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649221153&partnerID=MN8TOARS. 10.1002/term.226 Dos Santos, F.; Andrade, P.Z.; Boura, J.S.; Abecasis, M.M.; Da Silva, C.L.; Cabral, J.M.S.. "Ex vivo expansion of human mesenchymal stem cells: A more effective cell proliferation kinetics and metabolism under hypoxia". Journal of Cellular Physiology 223 1 (2010): 27-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-75749145078&partnerID=MN8TOARS. 10.1002/jcp.21987 Eibes, G.; dos Santos, F.; Andrade, P.Z.; Boura, J.S.; Abecasis, M.M.A.; da Silva, C.L.; Cabral, J.M.S.. "Maximizing the ex vivo expansion of human mesenchymal stem cells using a microcarrier-based stirred culture system". Journal of Biotechnology 146 4 (2010): 194-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950457742&partnerID=MN8TOARS. 10.1016/j.jbiotec.2010.02.015 Badenes, S.M.; Lemos, F.; Cabral, J.M.S.. "Transesterification of oil mixtures catalyzed by microencapsulated cutinase in reversed micelles". Biotechnology Letters 32 3 (2010): 399-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649336752&partnerID=MN8TOARS. 10.1007/s10529-009-0172-5 Marques, M.P.C.; Carvalho, F.; de Carvalho, C.C.C.R.; Cabral, J.M.S.; Fernandes, P.. "Steroid bioconversion: Towards green processes". Food and Bioproducts Processing 88 1 (2010): 12-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949271542&partnerID=MN8TOARS. 10.1016/j.fbp.2010.01.009 Fernandes, T.G.; Diogo, M.M.; Fernandes-Platzgummer, A.; da Silva, C.L.; Cabral, J.M.S.. "Different stages of pluripotency determine distinct patterns of proliferation, metabolism, and lineage commitment of embryonic stem cells under hypoxia". Stem Cell Research 5 1 (2010): 76-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953286613&partnerID=MN8TOARS. 10.1016/j.scr.2010.04.003 Da Silva, C.L.; Madeira, C.; Mendes, R.D.; Ribeiro, S.C.; Boura, J.S.; Aires-Barros, M.R.; Cabral, J.M.S.. "Nonviral gene delivery to mesenchymal stem cells using cationic liposomes for gene and cell therapy". Journal of Biomedicine and Biotechnology 2010 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77955411071&partnerID=MN8TOARS. 10.1155/2010/735349 De Barros, D.P.C.; Fonseca, L.P.; Cabral, J.M.S.; Aschenbrenner, E.M.; Weiss, C.K.; Landfester, K.. "Miniemulsion as efficient system for enzymatic synthesis of acid alkyl esters". Biotechnology and Bioengineering 106 4 (2010): 507-515. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954253403&partnerID=MN8TOARS. 10.1002/bit.22726 Badenes, S.M.; Lemos, F.; Cabral, J.M.S.. "Assessing the use of cutinase reversed micellar catalytic system for the production of biodiesel from triglycerides". Journal of Chemical Technology and Biotechnology 85 7 (2010): 993-998. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953500288&partnerID=MN8TOARS. 10.1002/jctb.2393 De Barros, D.P.C.; Lemos, F.; Fonseca, L.P.; Cabral, J.M.S.. "Kinetic cutinase-catalyzed esterification of caproic acid in organic solvent system". Journal of Molecular Catalysis B: Enzymatic 66 3-4 (2010): 285-293. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955981941&partnerID=MN8TOARS. 10.1016/j.molcatb.2010.06.005 De Barros, D.P.C.; Fernandes, P.; Cabral, J.M.S.; Fonseca, L.P.. "Operational stability of cutinase in organic solvent system: Model esterification of alkyl esters". Journal of Chemical Technology and Biotechnology 85 12 (2010): 1553-1560. http://www.scopus.com/inward/record.url?eid=2-s2.0-78349288835&partnerID=MN8TOARS. 10.1002/jctb.2464 Marques, M.P.C.; Cabral, J.M.S.; Fernandes, P.. "Bioprocess scale-up: Quest for the parameters to be used as criterion to move from microreactors to lab-scale". Journal of Chemical Technology and Biotechnology 85 9 (2010): 1184-1198. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956510121&partnerID=MN8TOARS. 10.1002/jctb.2387 Ribeiro, S.C.; Mendes, R.; Madeira, C.; Monteiro, G.A.; da Silva, C.L.; Cabral, J.M.. "A quantitative method to evaluate mesenchymal stem cell lipofection using real-time PCR.". Biotechnology progress 26 5 (2010): 1501-1504. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952277481&partnerID=MN8TOARS. Calado, C.R.C.; Brandao, M.; Biscaia, J.; Cabral, J.M.S.; Fonseca, L.P.. "Effect of Tween-80 on stability and secretion of hydrophobic tagged-cutinases". Chemical and Biochemical Engineering Quarterly 23 4 (2009): 411-417. http://www.scopus.com/inward/record.url?eid=2-s2.0-74549134637&partnerID=MN8TOARS. Carvalho, F.; Marques, M.P.C.; Carvalho, C.C.C.R.d.; Cabral, J.M.S.; Fernandes, P.. "Sitosterol bioconversion with resting cells in liquid polymer based systems". Bioresource Technology 100 17 (2009): 4050-4053. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349117272&partnerID=MN8TOARS. 10.1016/j.biortech.2009.03.044 de Barros, D.P.C.; Fonseca, L.P.; Cabral, J.M.S.; Weiss, C.K.; Landfester, K.. "Synthesis of alkyl esters by cutinase in miniemulsion and organic solvent media". Biotechnology Journal 4 5 (2009): 674-683. http://www.scopus.com/inward/record.url?eid=2-s2.0-68049095936&partnerID=MN8TOARS. 10.1002/biot.200800294 Costa, L.; Coelho, A.; Lemos, F.; Ramôa Ribeiro, F.; Cabral, J.M.S.. "Modulating the acid strength of zeolite H-ZSM-5 to increase the selectivity in the racemization of 1-phenylethanol". Applied Catalysis A: General 354 1-2 (2009): 33-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-58249141635&partnerID=MN8TOARS. 10.1016/j.apcata.2008.11.001 Fernandes, T.G.; Fernandes-Platzgummer, A.M.; da Silva, C.L.; Diogo, M.M.; Cabral, J.M.S.. "Kinetic and metabolic analysis of mouse embryonic stem cell expansion under serum-free conditions". Biotechnology Letters 32 1 (2009): 171-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-72249097517&partnerID=MN8TOARS. 10.1007/s10529-009-0108-0 Marques, M.P.C.; Carvalho, F.; Magalhães, S.; Cabral, J.M.S.; Fernandes, P.. "Screening for suitable solvents as substrate carriers for the microbial side-chain cleavage of sitosterol using microtitre plates". Process Biochemistry 44 5 (2009): 556-561. http://www.scopus.com/inward/record.url?eid=2-s2.0-64049116045&partnerID=MN8TOARS. 10.1016/j.procbio.2009.01.014 Temtem, M.; Silva, L.M.C.; Andrade, P.Z.; dos Santos, F.; da Silva, C.L.; Cabral, J.M.S.; Abecasis, M.M.; Aguiar-Ricardo, A.. "Supercritical CO2 generating chitosan devices with controlled morphology. Potential application for drug delivery and mesenchymal stem cell culture". Journal of Supercritical Fluids 48 3 (2009): 269-277. http://www.scopus.com/inward/record.url?eid=2-s2.0-61549084665&partnerID=MN8TOARS. 10.1016/j.supflu.2008.10.020 Costa, L.; Brissos, V.; Lemos, F.; Ramôa Ribeiro, F.; Cabral, J.M.S.. "Enhancing the thermal stability of lipases through mutagenesis and immobilization on zeolites". Bioprocess and Biosystems Engineering 32 1 (2009): 53-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149092996&partnerID=MN8TOARS. 10.1007/s00449-008-0220-x Cattorini, S.; Marques, M.P.C.; Carvalho, F.; Chheub, V.; Cabral, J.M.S.; Fernandes, P.. "Lentikat®-based biocatalysts: Effective tools for inulin hydrolysis". Chemical and Biochemical Engineering Quarterly 23 4 (2009): 429-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-74549204570&partnerID=MN8TOARS. Fernandes, P.; Marques, M.P.C.; Carvalho, F.; Cabral, J.M.S.. "A simple method for biocatalyst immobilization using PVA-based hydrogel particles". Journal of Chemical Technology and Biotechnology 84 4 (2009): 561-564. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449116849&partnerID=MN8TOARS. 10.1002/jctb.2080 Da Silva, C.L.; Gonçalves, R.; Porada, C.D.; Ascensão, J.L.; Zanjani, E.D.; Cabral, J.M.S.; Almeida-Porada, G.. "Differences amid bone marrow and cord blood hematopoietic stem/progenitor cell division kinetics". Journal of Cellular Physiology 220 1 (2009): 102-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549085564&partnerID=MN8TOARS. 10.1002/jcp.21736 Marques, M.P.C.; Magalhães, S.; Cabral, J.M.S.; Fernandes, P.. "Characterization of 24-well microtiter plate reactors for a complex multistep bioconversion: From sitosterol to androstenedione". Journal of Biotechnology 141 3-4 (2009): 174-180. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349150484&partnerID=MN8TOARS. 10.1016/j.jbiotec.2009.03.007 Fernandes, T.G.; Diogo, M.M.; Clark, D.S.; Dordick, J.S.; Cabral, J.M.S.. "High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research". Trends in Biotechnology 27 6 (2009): 342-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549112285&partnerID=MN8TOARS. 10.1016/j.tibtech.2009.02.009 Serro, A.P.; Completo, C.; Colaço, R.; dos Santos, F.; da Silva, C.L.; Cabral, J.M.S.; Araújo, H.; Pires, E.; Saramago, B.. "A comparative study of titanium nitrides, TiN, TiNbN and TiCN, as coatings for biomedical applications". Surface and Coatings Technology 203 24 (2009): 3701-3707. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650108479&partnerID=MN8TOARS. 10.1016/j.surfcoat.2009.06.010 de Barros, D.P.C.; Fonseca, L.P.; Fernandes, P.; Cabral, J.M.S.; Mojovic, L.. "Biosynthesis of ethyl caproate and other short ethyl esters catalyzed by cutinase in organic solvent". Journal of Molecular Catalysis B: Enzymatic 60 3-4 (2009): 178-185. http://www.scopus.com/inward/record.url?eid=2-s2.0-68149151029&partnerID=MN8TOARS. 10.1016/j.molcatb.2009.05.004 Cardoso, MAT; Antunes, S; van Keulen, F; Ferreira, BS; Geraldes, A; Cabral, JMS; Palavra, AMF. "Supercritical antisolvent micronisation of synthetic all-trans-beta-carotene with tetrahydrofuran as solvent and carbon dioxide as antisolvent". Journal of Chemical Technology and Biotechnology 84 2 (2009): 215-222. 10.1002/jctb.2027 Vidinha, P.; Lourenço, N.M.T.; Pinheiro, C.; Brás, A.R.; Carvalho, T.; Santos-Silva, T.; Mukhopadhyay, A.; et al. "Ion jelly: A tailor-made conducting material for smart electrochemical devices". Chemical Communications 44 (2008): 5842-5844. http://www.scopus.com/inward/record.url?eid=2-s2.0-56349138178&partnerID=MN8TOARS. 10.1039/b811647d Fernandes, T.G.; Kwon, S.-J.; Lee, M.-Y.; Clark, D.S.; Cabral, J.M.S.; Dordick, J.S.. "On-chip, cell-based microarray immunofluorescence assay for high-throughput analysis of target proteins". Analytical Chemistry 80 17 (2008): 6633-6639. http://www.scopus.com/inward/record.url?eid=2-s2.0-51549106300&partnerID=MN8TOARS. 10.1021/ac800848j Cardoso, M.A.T.; Cabral, J.M.S.; Palavra, A.M.F.; Geraldes, V.. "CFD analysis of supercritical antisolvent (SAS) micronization of minocycline hydrochloride". Journal of Supercritical Fluids 47 2 (2008): 247-258. http://www.scopus.com/inward/record.url?eid=2-s2.0-53749085051&partnerID=MN8TOARS. 10.1016/j.supflu.2008.08.008 Lienqueo, M.E.; Salazar, O.; Calado, C.R.C.; Fonseca, L.P.; Cabral, J.M.S.. "Influence of tryptophan tags on the purification of cutinase, secreted by a recombinant Saccharomyces cerevisiae, using cationic expanded bed adsorption and hydrophobic interaction chromatography". Biotechnology Letters 30 8 (2008): 1353-1358. http://www.scopus.com/inward/record.url?eid=2-s2.0-45849134880&partnerID=MN8TOARS. 10.1007/s10529-008-9696-3 Tavares Cardoso, M.A.; Geraldes, V.; Cabral, J.M.S.; Palavra, A.M.F.. "Characterization of minocycline powder micronized by a supercritical antisolvent (SAS) process". Journal of Supercritical Fluids 46 1 (2008): 71-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449107997&partnerID=MN8TOARS. 10.1016/j.supflu.2008.02.018 Brissos, V.; Melo, E.P.; Martinho, J.M.G.; Cabral, J.M.S.. "Biochemical and structural characterisation of cutinase mutants in the presence of the anionic surfactant AOT". Biochimica et Biophysica Acta - Proteins and Proteomics 1784 9 (2008): 1326-1334. http://www.scopus.com/inward/record.url?eid=2-s2.0-53149145988&partnerID=MN8TOARS. 10.1016/j.bbapap.2008.04.017 Costa, L.; Brissos, V.; Lemos, F.; Ribeiro, F.R.; Cabral, J.M.S.. "Following multi-component reactions in liquid medium using spectral band-fitting techniques". Applied Spectroscopy 62 8 (2008): 932-935. http://www.scopus.com/inward/record.url?eid=2-s2.0-50149098977&partnerID=MN8TOARS. Vidinha, P.; Augusto, V.; Nunes, J.; Lima, J.C.; Cabral, J.M.S.; Barreiros, S.. "Probing the microenvironment of sol-gel entrapped cutinase: The role of added zeolite NaY". Journal of Biotechnology 135 2 (2008): 181-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-44149084162&partnerID=MN8TOARS. 10.1016/j.jbiotec.2008.03.018 Brissos, V.; Eggert, T.; Cabral, J.M.S.; Jaeger, K.-E.. "Improving activity and stability of cutinase towards the anionic detergent AOT by complete saturation mutagenesis". Protein Engineering, Design and Selection 21 6 (2008): 387-393. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649102734&partnerID=MN8TOARS. 10.1093/protein/gzn014 Costa, L.; Brissos, V.; Lemos, F.; Ribeiro, F.R.; Cabral, J.M.S.. "Comparing the effect of immobilization methods on the activity of lipase biocatalysts in ester hydrolysis". Bioprocess and Biosystems Engineering 31 4 (2008): 323-327. http://www.scopus.com/inward/record.url?eid=2-s2.0-44049097661&partnerID=MN8TOARS. 10.1007/s00449-007-0165-5 Costa, L.F.A.; Lemos, F.; Ribeiro, F.R.; Cabral, J.M.S.. "Zeolite screening for the racemization of 1-phenylethanol". Catalysis Today 133-135 1-4 (2008): 625-631. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149099070&partnerID=MN8TOARS. 10.1016/j.cattod.2007.11.041 Baptista, R.P.; Pedersen, S.; Cabrita, G.J.M.; Otzen, D.E.; Cabral, J.M.S.; Melo, E.P.. "Thermodynamics and mechanism of cutinase stabilization by trehalose". Biopolymers 89 6 (2008): 538-547. http://www.scopus.com/inward/record.url?eid=2-s2.0-44849111668&partnerID=MN8TOARS. 10.1002/bip.20926 Carvalho, R.H.; Lemos, M.A.N.D.A.; Lemos, F.; Cabral, J.M.S.; Ribeiro, F.R.. "Electro-oxidation of phenol on zeolite/graphite composite electrodes. Part 3. Influence of the electrolyte and of nonelectroactive cations". Catalysis Today 133-135 1-4 (2008): 855-862. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149123816&partnerID=MN8TOARS. 10.1016/j.cattod.2007.12.133 Sampaio, P.N.; Fortes, A.M.; Cabral, J.M.S.; Pais, M.S.; Fonseca, L.P.. "Production and characterization of recombinant cyprosin B in Saccharomyces cerevisiae (W303-1A) strain". Journal of Bioscience and Bioengineering 105 4 (2008): 305-312. http://www.scopus.com/inward/record.url?eid=2-s2.0-43549092879&partnerID=MN8TOARS. 10.1263/jbb.105.305 Claudino, M.J.C.; Soares, D.; Van Keulen, F.; Marques, M.P.C.; Cabral, J.M.S.; Fernandes, P.. "Immobilization of mycobacterial cells onto silicone - Assessing the feasibility of the immobilized biocatalyst in the production of androstenedione from sitosterol". Bioresource Technology 99 7 (2008): 2304-2311. http://www.scopus.com/inward/record.url?eid=2-s2.0-38849187381&partnerID=MN8TOARS. 10.1016/j.biortech.2007.05.007 Vidinha, P.; Barreiros, S.; Cabral, J.M.S.; Nunes, T.G.; Fidalgo, A.; Ilharco, L.M.. "Enhanced biocatalytic activity of ORMOSIL-encapsulated cutinase: The matrix structural perspective". Journal of Physical Chemistry C 112 6 (2008): 2008-2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-40049095813&partnerID=MN8TOARS. 10.1021/jp0761867 Diogo, M.M.; Henrique, D.; Cabral, J.M.S.. "Optimization and integration of expansion and neural commitment of mouse embryonic stem cells". Biotechnology and Applied Biochemistry 49 2 (2008): 105-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-38749092143&partnerID=MN8TOARS. 10.1042/BA20070011 Santos, A.M.; Fedorov, A.; Martinho, J.M.G.; Baptista, R.P.; Taipa, M.A.; Cabral, J.M.S.. "Orientation of cutinase adsorbed onto PMMA nanoparticles probed by tryptophan fluorescence". Journal of Physical Chemistry B 112 12 (2008): 3581-3585. http://www.scopus.com/inward/record.url?eid=2-s2.0-43049181786&partnerID=MN8TOARS. 10.1021/jp711903e Cardoso, M.A.T.; Monteiro, G.A.; Cardoso, J.P.; Prazeres, T.J.V.; Figueiredo, J.M.F.; Martinho, J.M.G.; Cabral, J.M.S.; Palavra, A.M.F.. "Supercritical antisolvent micronization of minocycline hydrochloride". Journal of Supercritical Fluids 44 2 (2008): 238-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-39149143030&partnerID=MN8TOARS. 10.1016/j.supflu.2007.09.035 Frias, A.M.; Porada, C.D.; Crapnell, K.B.; Cabral, J.M.S.; Zanjani, E.D.; Almeida-Porada, G.. "Generation of functional natural killer and dendritic cells in a human stromal-based serum-free culture system designed for cord blood expansion". Experimental Hematology 36 1 (2008): 61-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-37249025216&partnerID=MN8TOARS. 10.1016/j.exphem.2007.08.031 Vojinovic, V.; Carvalho, R.H.; Lemos, F.; Cabral, J.M.S.; Fonseca, L.P.; Ferreira, B.S.. "Kinetics of soluble and immobilized horseradish peroxidase-mediated oxidation of phenolic compounds". Biochemical Engineering Journal 35 2 (2007): 126-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247898977&partnerID=MN8TOARS. 10.1016/j.bej.2007.01.006 Cabral, J.M.S.. "Cell partitioning in aqueous two-phase polymer systems". Advances in Biochemical Engineering/Biotechnology 106 (2007): 151-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-38449117066&partnerID=MN8TOARS. 10.1007/10_2006_045 Abranches, E.; Bekman, E.; Henrique, D.; Cabral, J.M.S.. "Expansion of mouse embryonic stem cells on microcarriers". Biotechnology and Bioengineering 96 6 (2007): 1211-1221. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247101508&partnerID=MN8TOARS. 10.1002/bit.21191 Fernandes, A.M.; Fernandes, T.G.; Diogo, M.M.; da Silva, C.L.; Henrique, D.; Cabral, J.M.S.. "Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system". Journal of Biotechnology 132 2 (2007): 227-236. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348996645&partnerID=MN8TOARS. 10.1016/j.jbiotec.2007.05.031 Marques, M.P.C.; de Carvalho, C.C.C.R.; Claudino, M.J.C.; Cabral, J.M.S.; Fernandes, P.. "On the feasibility of the microscale approach for a multistep biotransformation: Sitosterol side chain cleavage". Journal of Chemical Technology and Biotechnology 82 9 (2007): 856-863. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548356971&partnerID=MN8TOARS. 10.1002/jctb.1756 Carvalho, R.H.; Lemos, F.; Lemos, M.A.N.D.A.; Cabral, J.M.S.; Ramôa Ribeiro, F.. "Electro-oxidation of phenol on a new type of zeolite/graphite biocomposite electrode with horseradish peroxidase". Journal of Molecular Catalysis A: Chemical 278 1-2 (2007): 47-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-35748945128&partnerID=MN8TOARS. 10.1016/j.molcata.2007.08.009 Lienqueo, M.E.; Salazar, O.; Henriquez, K.; Calado, C.R.C.; Fonseca, L.P.; Cabral, J.M.S.. "Prediction of retention time of cutinases tagged with hydrophobic peptides in hydrophobic interaction chromatography". Journal of Chromatography A 1154 1-2 (2007): 460-463. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249679202&partnerID=MN8TOARS. 10.1016/j.chroma.2007.03.088 Fernandes, P.; Cabral, J.M.S.. "Phytosterols: Applications and recovery methods". Bioresource Technology 98 12 (2007): 2335-2350. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947241794&partnerID=MN8TOARS. 10.1016/j.biortech.2006.10.006 Chen, Z.; Franco, C.F.; Baptista, R.P.; Cabral, J.M.S.; Coelho, A.V.; Rodrigues Jr., C.J.; Melo, E.P.. "Purification and identification of cutinases from Colletotrichum kahawae and Colletotrichum gloeosporioides". Applied Microbiology and Biotechnology 73 6 (2007): 1306-1313. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846176102&partnerID=MN8TOARS. 10.1007/s00253-006-0605-1 Dias, A.I.; Feliciano, A.S.; Cabral, J.M.S.; Prazeres, D.M.F.. "Chemical synthesis and crystallization of the dipeptide AcPheIleNH2 in TTAB/heptane/octanol reversed micelles". Journal of Colloid and Interface Science 305 1 (2007): 198-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750958876&partnerID=MN8TOARS. 10.1016/j.jcis.2006.09.052 Carvalho, R.H.; Lemos, F.; Cabral, J.M.S.; Ribeiro, F.R.. "Influence of the presence of NaY zeolite on the activity of horseradish peroxidase in the oxidation of phenol". Journal of Molecular Catalysis B: Enzymatic 44 2 (2007): 39-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845964641&partnerID=MN8TOARS. 10.1016/j.molcatb.2006.08.008 Carvalho, R.H.; Lemos, F.; Lemos, M.A.N.D.A.; Cabral, J.M.S.; Ribeiro, F.R.. "Electro-oxidation of phenol on zeolite/graphite composite electrodes: Part 1. Electrochemical behaviour over NaY zeolite". Journal of Molecular Catalysis A: Chemical 248 1-2 (2006): 48-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645408353&partnerID=MN8TOARS. 10.1007/s10787-006-1509-5 Angelova, B.; Fernandes, P.; Spasova, D.; Mutafov, S.; Pinheiro, H.M.; Cabral, J.M.S.. "Scanning electron microscopy investigations on bis(2-ethylhexyl)phthalate treated Mycobacterium cells". Microscopy Research and Technique 69 8 (2006): 613-617. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747880878&partnerID=MN8TOARS. 10.1002/jemt.20327 Carvalho, R.H.; Lemos, M.A.N.D.A.; Lemos, F.; Cabral, J.M.S.; Ribeiro, F.R.. "Electro-oxidation of phenol on zeolite/graphite composite electrodes. Part 2. Influence of zeolite type and composition". Journal of Molecular Catalysis A: Chemical 253 1-2 (2006): 170-175. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646864532&partnerID=MN8TOARS. 10.1016/j.molcata.2006.03.034 Vidinha, P; Augusto, V; Almeida, M; Fonseca, I; Fidalgo, A; Ilharco, L; Cabral, JMS; Barreiros, S. "Sol-gel encapsulation: An efficient and versatile immobilization technique for cutinase in non-aqueous media". Journal of Biotechnology 121 1 (2006): 23-33. 10.1016/j.jbiotec.2005.06.018 de Assis, S.A.; Ferreira, B.S.; Fernandes, P.; Trevisan, H.C.; Cabral, J.M.S.; Oliveira, O.M.M.F.. "Production of low methoxyl pectin using immobilized pectinmethylesterase silica from acerola (Malpighia glabra L.)". Journal of Chemical Technology and Biotechnology 81 4 (2006): 706-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646195684&partnerID=MN8TOARS. 10.1002/jctb.1382 Díaz, E.G.; Catana, R.; Ferreira, B.S.; Luque, S.; Fernandes, P.; Cabral, J.M.S.. "Towards the development of a membrane reactor for enzymatic inulin hydrolysis". Journal of Membrane Science 273 1-2 (2006): 152-158. http://www.scopus.com/inward/record.url?eid=2-s2.0-32444445993&partnerID=MN8TOARS. 10.1016/j.memsci.2005.12.005 Abranches, E.; O'Neill, A.; Robertson, M.J.; Schaffer, D.V.; Cabral, J.M.S.. "Development of quantitative PCR methods to analyse neural progenitor cell culture state". Biotechnology and Applied Biochemistry 44 1 (2006): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645665451&partnerID=MN8TOARS. 10.1042/BA20050218 Vojinovic, V.; Bertin, L.; Cabral, J.M.S.; Fonseca, L.P.. "Horseradich peroxidase combined with oxidase enzymes a valuable bioanalytical tool: Lactate oxidase - A case study". Engineering in Life Sciences 6 2 (2006): 181-186. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645748638&partnerID=MN8TOARS. 10.1002/elsc.200620908 Valente, C.A.; Monteiro, G.A.; Cabral, J.M.S.; Fevereiro, M.; Prazeres, D.M.F.. "Optimization of the primary recovery of human interferon a2b from Escherichia coli inclusion bodies". Protein Expression and Purification 45 1 (2006): 226-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-28844455097&partnerID=MN8TOARS. 10.1016/j.pep.2005.06.014 Rocha, J.R.; Catana, R.; Ferreira, B.S.; Cabral, J.M.S.; Fernandes, P.. "Design and characterisation of an enzyme system for inulin hydrolysis". Food Chemistry 95 1 (2006): 77-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-31844441344&partnerID=MN8TOARS. 10.1016/j.foodchem.2004.12.020 Gonçalves, R.; Silva, C.L.D.; Ferreira, B.S.; Lemos, M.A.N.D.A.; Lemos, F.; Almeida-Porada, G.; Cabral, J.M.S.. "Kinetic analysis of the ex vivo expansion of human hematopoietic stem/progenitor cells". Biotechnology Letters 28 5 (2006): 335-340. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645891444&partnerID=MN8TOARS. 10.1007/s10529-005-5932-2 Gonçalves, R.; Lobato da Silva, C.; Cabral, J.M.S.; Zanjani, E.D.; Almeida-Porada, G.. "A Stro-1+ human universal stromal feeder layer to expand/maintain human bone marrow hematopoietic stem/progenitor cells in a serum-free culture system". Experimental Hematology 34 10 (2006): 1353-1359. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748528996&partnerID=MN8TOARS. 10.1016/j.exphem.2006.05.024 Almeida, C.F.; Calado, C.R.C.; Bernardino, S.A.; Cabral, J.M.S.; Fonseca, L.P.. "A flow injection analysis system for on-line monitoring of cutinase activity at outlet of an expanded bed adsorption column almost in real time". Journal of Chemical Technology and Biotechnology 81 10 (2006): 1678-1684. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749357814&partnerID=MN8TOARS. 10.1002/jctb.1587 Cardoso, F.; Ferreira, H.; Freitas, P.; Conde, J.; Chu, V.; Germano, J.; Sousa, L.; et al. "Scalable magnetoresistive biochips for biomolecular recognition". INTERMAG 2006 - IEEE International Magnetics Conference (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-50249182117&partnerID=MN8TOARS. 10.1109/INTMAG.2006.375831 Silva, C.S.O.; Baptista, R.P.; Santos, A.M.; Martinho, J.M.G.; Cabral, J.M.S.; Taipa, M.Â.. "Adsorption of human IgG on to poly(N-isopropylacrylamide)-based polymer particles". Biotechnology Letters 28 24 (2006): 2019-2025. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845297264&partnerID=MN8TOARS. 10.1007/s10529-006-9188-2 Carvalho, R.H.; Lemos, F.; Lemos, M.A.N.D.A.; Vojinovic, V.; Fonseca, L.P.; Cabral, J.M.S.. "Kinetic modelling of phenol co-oxidation using horseradish peroxidase". Bioprocess and Biosystems Engineering 29 2 (2006): 99-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745698116&partnerID=MN8TOARS. 10.1007/s00449-006-0057-0 Catana, R.; Eloy, M.; Rocha, J.R.; Ferreira, B.S.; Cabral, J.M.S.; Fernandes, P.. "Stability evaluation of an immobilized enzyme system for inulin hydrolysis". Food Chemistry 101 1 (2006): 260-266. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747096920&partnerID=MN8TOARS. 10.1016/j.foodchem.2006.01.042 Vojinovic, V.; Esteves, F.M.F.; Cabral, J.M.S.; Fonseca, L.P.. "Bienzymatic analytical microreactors for glucose, lactate, ethanol, galactose and l-amino acid monitoring in cell culture media". Analytica Chimica Acta 565 2 (2006): 240-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646046164&partnerID=MN8TOARS. 10.1016/j.aca.2006.02.042 Fernandes, P.; Cabral, J.M.S.. "Microlitre/millilitre shaken bioreactors in fermentative and biotransformation processes - A review". Biocatalysis and Biotransformation 24 4 (2006): 237-252. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747343757&partnerID=MN8TOARS. 10.1080/10242420600667684 Vojinovic, V.; Cabral, J.M.S.; Fonseca, L.P.. "Real-time bioprocess monitoring: Part I: In situ sensors". Sensors and Actuators, B: Chemical 114 2 (2006): 1083-1091. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645217831&partnerID=MN8TOARS. 10.1016/j.snb.2005.07.059 Da Silva, C.L.; Gonçalves, R.; Crapnell, K.B.; Cabral, J.M.S.; Zanjani, E.D.; Almeida-Porada, G.. "A human stromal-based serum-free culture system supports the ex vivo expansion/maintenance of bone marrow and cord blood hematopoietic stem/progenitor cells". Experimental Hematology 33 7 (2005): 828-835. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444500801&partnerID=MN8TOARS. 10.1016/j.exphem.2005.03.017 Silva, C. M.; Carneiro, F.; O'Neill, A.; Fonseca, L. P.; Cabral, J. S. M.; Guebitz, G.; Cavaco-Paulo, A.. "Cutinase - A new tool for biomodification of synthetic fibers". Journal of Polymer Science Part a-Polymer Chemistry 43 11 (2005): 2448-2450. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000229086900025&KeyUID=WOS:000229086900025. 10.1002/pola.20684 Angelova, B.; Fernandes, P.; Cruz, A.; Pinheiro, H.M.; Mutafov, S.; Cabral, J.M.S.. "Hydroxylation of androstenedione by resting Rhodococcus sp. cells in organic media". Enzyme and Microbial Technology 37 7 (2005): 718-722. http://www.scopus.com/inward/record.url?eid=2-s2.0-25444442046&partnerID=MN8TOARS. 10.1016/j.enzmictec.2005.04.014 Catana, R.; Ferreira, B.S.; Cabral, J.M.S.; Fernandes, P.. "Immobilization of inulinase for sucrose hydrolysis". Food Chemistry 91 3 (2005): 517-520. http://www.scopus.com/inward/record.url?eid=2-s2.0-11144317788&partnerID=MN8TOARS. 10.1016/j.foodchem.2004.04.041 Azevedo, A.M.; Prazeres, D.M.F.; Cabral, J.M.S.; Fonseca, L.P.. "Ethanol biosensors based on alcohol oxidase". Biosensors and Bioelectronics 21 2 (2005): 235-247. http://www.scopus.com/inward/record.url?eid=2-s2.0-22044453261&partnerID=MN8TOARS. 10.1016/j.bios.2004.09.030 Garcia, S.; Vidinha, P.; Arvana, H.; Gomes Da Silva, M.D.R.; Ferreira, M.O.; Cabral, J.M.S.; MacEdo, E.A.; Harper, N.; Barreiros, S.. "Cutinase activity in supercritical and organic media: Water activity, solvation and acid-base effects". Journal of Supercritical Fluids 35 1 (2005): 62-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-21244445702&partnerID=MN8TOARS. 10.1016/j.supflu.2004.10.011 Vojinovic, V.; Calado, C.R.; Silva, A.I.; Mateus, M.; Cabral, J.M.S.; Fonseca, L.P.. "Micro-analytical GO/HRP bioreactor for glucose determination and bioprocess monitoring". Biosensors and Bioelectronics 20 10 SPEC. I (2005): 1955-1961. http://www.scopus.com/inward/record.url?eid=2-s2.0-14644389383&partnerID=MN8TOARS. 10.1016/j.bios.2004.08.015 Wendhausen, R.; Frigato, M.; Fernandes, P.; Carvalho, C.C.C.R.; Cruz, A.; Pinheiro, H.M.; Cabral, J.M.S.. "Chrysotile as a support for the immobilisation of Mycobacterium sp. NRRL B-3805 cells for the bioconversion of ß-sitosterol in an organic-aqueous two-liquid phase system". Journal of Molecular Catalysis B: Enzymatic 32 3 (2005): 61-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-12344271054&partnerID=MN8TOARS. 10.1016/j.molcatb.2004.10.001 Garcia, S.; Lourenço, N.M.T.; Lousa, D.; Sequeira, A.F.; Mimoso, P.; Cabral, J.M.S.; Afonso, C.A.M.; Barreiros, S.. "A comparative study of biocatalysis in non-conventional solvents: Ionic liquids, supercritical fluids and organic media". Green Chemistry 6 9 (2004): 466-470. http://www.scopus.com/inward/record.url?eid=2-s2.0-8144227149&partnerID=MN8TOARS. 10.1039/b405614k Vojinovic, V.; Azevedo, A.M.; Martins, V.C.B.; Cabral, J.M.S.; Gibson, T.D.; Fonseca, L.P.. "Assay of H2O2 by HRP catalysed co-oxidation of phenol-4-sulphonic acid and 4-aminoantipyrine: Characterisation and optimisation". Journal of Molecular Catalysis B: Enzymatic 28 2-3 (2004): 129-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842685386&partnerID=MN8TOARS. 10.1016/j.molcatb.2004.02.003 De Carvalho, C.C.C.R.; Da Cruz, A.A.R.L.; Pons, M.-N.; Pinheiro, H.M.R.V.; Cabral, J.M.S.; Da Fonseca, M.M.R.; Ferreira, B.S.; Fernandes, P.. "Mycobacterium sp., Rhodococcus erythropolis, and Pseudomonas putida behavior in the presence of organic solvents". Microscopy Research and Technique 64 3 (2004): 215-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-4744372564&partnerID=MN8TOARS. 10.1002/jemt.20061 Cruz, A.; Fernandes, P.; Cabral, J.M.S.; Pinheiro, H.M.. "Solvent partitioning and whole-cell sitosterol bioconversion activity in aqueous-organic two-phase systems". Enzyme and Microbial Technology 34 3-4 (2004): 342-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-0442323434&partnerID=MN8TOARS. 10.1016/j.enzmictec.2003.11.007 Xue-Jun, C.; Xing-Yan, W.; Fonseca, L.J.P.; Cabral, J.M.S.; Marcos, J.C.. "Production of 6-aminopenicillanic acid in aqueous two-phase systems by recombinant Escherichia coli with intracellular penicillin acylase". Biotechnology Letters 26 2 (2004): 97-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-1042268335&partnerID=MN8TOARS. 10.1023/B:BILE.0000012885.62462.f3 Valente, C.A.; Prazeres, D.M.F.; Cabral, J.M.S.; Monteiro, G.A.. "Translational features of human alpha 2b interferon production in Escherichia coli". Applied and Environmental Microbiology 70 8 (2004): 5033-5036. http://www.scopus.com/inward/record.url?eid=2-s2.0-4143142271&partnerID=MN8TOARS. 10.1128/AEM.70.8.5033-5036.2004 De Carvalho, C.C.C.R.; Cruz, A.; Angelova, B.; Fernandes, P.; Pons, M.N.; Pinheiro, H.M.; Cabral, J.M.S.; Da Fonseca, M.M.R.. "Behaviour of Mycobacterium sp. NRRL B-3805 whole cells in aqueous, organic-aqueous and organic media studied by fluorescence microscopy". Applied Microbiology and Biotechnology 64 5 (2004): 695-701. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042567018&partnerID=MN8TOARS. 10.1007/s00253-003-1508-z De Assis, S.A.; Ferreira, B.S.; Fernandes, P.; Guaglianoni, D.G.; Cabral, J.M.S.; Oliveira, O.M.M.F.. "Gelatin-immobilized pectinmethylesterase for production of low methoxyl pectin". Food Chemistry 86 3 (2004): 333-337. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642395708&partnerID=MN8TOARS. 10.1016/j.foodchem.2003.09.040 Staebler, A.; Cruz, A.; Van Der Goot, W.; Pinheiro, H.M.; Cabral, J.M.S.; Fernandes, P.. "Optimization of androstenedione production in an organic-aqueous two-liquid phase system". Journal of Molecular Catalysis B: Enzymatic 29 1-6 (2004): 19-23. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442544587&partnerID=MN8TOARS. 10.1016/j.molcatb.2004.01.013 Azevedo, A.M.; Cabral, J.M.S.; Gibson, T.D.; Fonseca, L.P.. "Operation and performance of analytical packed-bed reactors with an immobilised alcohol oxidase". Journal of Molecular Catalysis B: Enzymatic 28 2-3 (2004): 45-53. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842786138&partnerID=MN8TOARS. 10.1016/j.molcatb.2004.01.001 Cruz, A.; Angelova, B.; Fernandes, P.; Cabral, J.M.S.; Pinheiro, H.M.. "Study of key operational parameters for the side-chain cleavage of sitosterol by free mycobacterial cells in bis-(2-ethylhexyl) phthalate". Biocatalysis and Biotransformation 22 3 (2004): 189-194. http://www.scopus.com/inward/record.url?eid=2-s2.0-4844229254&partnerID=MN8TOARS. 10.1080/10242420412331283297 Azevedo, A.M.; Vojinovic, V.; Cabral, J.M.S.; Gibson, T.D.; Fonseca, L.P.. "Operational stability of immobilised horseradish peroxidase in mini-packed bed bioreactors". Journal of Molecular Catalysis B: Enzymatic 28 2-3 (2004): 121-128. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842786129&partnerID=MN8TOARS. 10.1016/j.molcatb.2004.02.005 Mergulhão, F.J.M.; Taipa, M.A.; Cabral, J.M.S.; Monteiro, G.A.. "Evaluation of bottlenecks in proinsulin secretion by Escherichia coli". Journal of Biotechnology 109 1-2 (2004): 31-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842425886&partnerID=MN8TOARS. 10.1016/j.jbiotec.2003.10.024 Aparecida de Assis, S.; Fernandes, P.; Ferreira, B.S.; Cabral, J.M.S.; Mascarenhas Faria Oliveira, O.M.. "Screening of supports for the immobilization of pectinmethylesterase from acerola (Malpighia glabra L)". Journal of Chemical Technology and Biotechnology 79 3 (2004): 277-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-1442277732&partnerID=MN8TOARS. 10.1002/jctb.973 Calado, C.R.C.; Ferreira, B.S.; Da Fonseca, M.M.R.; Cabral, J.M.S.; Fonseca, L.P.. "Integration of the production and the purification processes of cutinase secreted by a recombinant Saccharomyces cerevisiae SU50 strain". Journal of Biotechnology 109 1-2 (2004): 147-158. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842478290&partnerID=MN8TOARS. 10.1016/j.jbiotec.2003.10.032 Ferreira, B.S.; Calado, C.R.C.; Van Keulen, F.; Fonseca, L.P.; Cabral, J.M.S.; Da Fonseca, M.M.R.. "Recombinant Saccharomyces cerevisiae strain triggers acetate production to fuel biosynthetic pathways". Journal of Biotechnology 109 1-2 (2004): 159-167. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842530401&partnerID=MN8TOARS. 10.1016/j.jbiotec.2003.10.033 Mergulhão, F.J.M.; Monteiro, G.A.; Cabral, J.M.S.; Taipa, M.A.. "Design of bacterial vector systems for the production of recombinant proteins in Escherichia coli". Journal of Microbiology and Biotechnology 14 1 (2004): 1-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-1542285371&partnerID=MN8TOARS. Silva, C.; Cabral, J.M.S.; Van Keulen, F.. "Isolation of a ß-carotene over-producing soil bacterium, Sphingomonas sp.". Biotechnology Letters 26 3 (2004): 257-262. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342288687&partnerID=MN8TOARS. 10.1023/B:BILE.0000013716.20116.dc Vidinha, P.; Harper, N.; Micaelo, N.M.; Lourenco, N.M.T.; Gomes Da Silva, M.D.R.; Cabral, J.; Afonso, C.A.M.; Soares, C.M.; Barreiros, S.. "Effect of Immobilization Support, Water Activity, and Enzyme Ionization State on Cutinase Activity and Enantioselectivity in Organic Media". Biotechnology and Bioengineering 85 4 (2004): 442-449. http://www.scopus.com/inward/record.url?eid=2-s2.0-0442278161&partnerID=MN8TOARS. 10.1002/bit.10780 Serralha, F.N.; Lopes, J.M.; Lemos, F.; Ramôa Ribeiro, F.; Prazeres, D.M.F.; Aires-Barros, M.R.; Cabral, J.M.S.. "Application of factorial design to the study of an alcoholysis transformation promoted by cutinase immobilized on NaY zeolite and Accurel PA6". Journal of Molecular Catalysis B: Enzymatic 27 1 (2004): 19-27. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346725817&partnerID=MN8TOARS. 10.1016/j.molcatb.2003.09.005 Almeida, C.F.; Cabral, J.M.S.; Fonseca, L.P.. "Flow injection analysis system for on-line cutinase activity assay". Analytica Chimica Acta 502 1 (2004): 115-124. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347627266&partnerID=MN8TOARS. 10.1016/j.aca.2003.09.048 Azevedo, A.M.; Cabral, J.M.S.; Prazeres, D.M.F.; Gibson, T.D.; Fonseca, L.P.. "Thermal and operational stabilities of Hansenula polymorpha alcohol oxidase". Journal of Molecular Catalysis B: Enzymatic 27 1 (2004): 37-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346095156&partnerID=MN8TOARS. 10.1016/j.molcatb.2003.09.001 Ferreira, B.S.; Calado, C.R.C.; Van Keulen, F.; Fonseca, L.P.; Cabral, J.M.S.; Da Fonseca, M.M.R.. "Towards a cost effective strategy for cutinase production by a recombinant Saccharomyces cerevisiae: Strain physiological aspects". Applied Microbiology and Biotechnology 61 1 (2003): 69-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037361724&partnerID=MN8TOARS. Azevedo, A.M.; Martins, V.C.; Prazeres, D.M.F.; Vojinovic, V.; Cabral, J.M.S.; Fonseca, L.P.. "Horseradish peroxidase: A valuable tool in biotechnology". Biotechnology Annual Review 9 (2003): 199-247. http://www.scopus.com/inward/record.url?eid=2-s2.0-1542440411&partnerID=MN8TOARS. 10.1016/S1387-2656(03)09003-3 Baptista, R.P.; Chen, L.Y.; Paixão, A.; Cabral, J.M.S.; Melo, E.P.. "A novel pathway to enzyme deactivation: The cutinase model". Biotechnology and Bioengineering 82 7 (2003): 851-857. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038247895&partnerID=MN8TOARS. 10.1002/bit.10641 Melo, E.P.; Baptista, R.P.; Cabral, J.M.S.. "Improving cutinase stability in aqueous solution and in reverse micelles by media engineering". Journal of Molecular Catalysis B: Enzymatic 22 5-6 (2003): 299-306. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038692188&partnerID=MN8TOARS. 10.1016/S1381-1177(03)00044-4 Mergulhão, F.J.M.; Monteiro, G.A.; Larsson, G.; Sandén, A.M.; Farewell, A.; Nystrom, T.; Cabral, J.M.S.; Taipa, M.A.. "Medium and copy number effects on the secretion of human proinsulin in Escherichia coli using the universal stress promoters uspA and uspB". Applied Microbiology and Biotechnology 61 5-6 (2003): 495-501. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037899027&partnerID=MN8TOARS. Abranches, E.; Bekman, E.; Henrique, D.; Cabral, J.M.S.. "Erratum: Expansion and neural differentiation of embryonic stem cells in adherent and suspension cultures (Biotechnology letters (2003) 25 (725-730))". Biotechnology Letters 25 12 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-0037742397&partnerID=MN8TOARS. Azevedo, A. M.; Martins, V. C.; Prazeres, D. M. F.; Vojinovic, V.; Cabral, J. M. S.; Fonseca, L. P.. "Horseradish peroxidase: a valuable tool in biotechnology". Biotechnology Annual Review, Vol 9 9 (2003): 199-247. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000189138100003&KeyUID=CCC:000189138100003. 10.1016/s1387-2656(03)09003-3 Fernandes, P; Ferreira, BS; Cabral, JMS. "Solvent tolerance in bacteria: role of efflux pumps and cross-resistance with antibiotics". International Journal of Antimicrobial Agents 22 3 (2003): 211-216. 10.1016/S0924-8579(03)00209-7 Ferreira, H.A.; Graham, D.L.; Freitas, P.P.; Cabral, J.M.S.. "Detection of biomolecular recognition using nanometer-sized magnetic labels and spin-valve sensors". Digests of the Intermag Conference (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-0141678492&partnerID=MN8TOARS. Calado, C.R.C.; Almeida, C.; Cabral, J.M.S.; Fonseca, L.P.. "Development of a fed-batch cultivation strategy for the enhanced production and secretion of cutinase by a recombinant Saccharomyces cerevisiae SU50 strain". Journal of Bioscience and Bioengineering 96 2 (2003): 141-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042733699&partnerID=MN8TOARS. 10.1016/S1389-1723(03)90116-2 Martins, S.A.M.; Prazeres, D.M.F.; Cabral, J.M.S.; Monteiro, G.A.. "Comparison of real-time polymerase chain reaction and hybridization assays for the detection of Escherichia coli genomic DNA in process samples and pharmaceutical-grade plasmid DNA products". Analytical Biochemistry 322 1 (2003): 127-129. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141535030&partnerID=MN8TOARS. 10.1016/j.ab.2003.07.004 Lobato Da Silva, C.; Gonçalves, R.; Lemos, F.; Lemos, M.A.N.D.A.; Zanjani, E.D.; Almeida-Porada, G.; Cabral, J.M.S.. "Modelling of ex vivo expansion/maintenance of hematopoietic stem cells". Bioprocess and Biosystems Engineering 25 6 (2003): 365-369. http://www.scopus.com/inward/record.url?eid=2-s2.0-0043130721&partnerID=MN8TOARS. 10.1007/s00449-002-0308-7 Alves, J.R.S.; Fonseca, L.P.; Ramalho, M.T.; Cabral, J.M.S.. "Optimisation of penicillin acylase extraction by AOT/isooctane reversed micellar systems". Biochemical Engineering Journal 15 2 (2003): 81-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038745371&partnerID=MN8TOARS. Mergulhão, F.J.M.; Monteiro, G.A.; Larsson, G.; Bostrom, M.; Farewell, A.; Nyström, T.; Cabral, J.M.S.; Taipa, M.A.. "Evaluation of inducible promoters on the secretion of a ZZ-proinsulin fusion protein in Escherichia coli". Biotechnology and Applied Biochemistry 38 1 (2003): 87-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042591085&partnerID=MN8TOARS. 10.1042/BA20030043 Melo, E.P.; Chen, L.Y.; Cabral, J.M.S.; Fojan, P.; Petersen, S.B.; Otzen, D.E.. "Trehalose favors a cutinase compact intermediate off-folding pathway". Biochemistry 42 24 (2003): 7611-7617. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038070096&partnerID=MN8TOARS. 10.1021/bi034267x Leirião, P.R.S.; Fonseca, L.J.P.; Taipa, M.A.; Cabral, J.M.S.; Mateus, M.. "Horseradish peroxidase immobilized through its carboxylic groups onto a polyacrylonitrile membrane: Comparison of enzyme performances with inorganic beaded supports". Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology 110 1 (2003): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042166222&partnerID=MN8TOARS. 10.1385/ABAB:110:1:1 Martinho, J.M.G.; Santos, A.M.; Fedorov, A.; Baptista, R.P.; Taipa, M.A.; Cabral, J.M.S.. "Fluorescence of the Single Tryptophan of Cutinase: Temperature and pH Effect on Protein Conformation and Dynamics". Photochemistry and Photobiology 78 1 (2003): 15-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242365531&partnerID=MN8TOARS. 10.1562/0031-8655(2003)078<0015:FOTSTO>2.0.CO;2 Melo, E.P.; Costa, S.M.B.; Cabral, J.M.S.; Fojan, P.; Petersen, S.B.. "Cutinase - AOT interactions in reverse micelles: The effect of 1-hexanol". Chemistry and Physics of Lipids 124 1 (2003): 37-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037685261&partnerID=MN8TOARS. 10.1016/S0009-3084(03)00031-8 Fernandes, P.; Prazeres, D.M.; Cabral, J.M.. "Membrane-assisted extractive bioconversions.". Advances in biochemical engineering/biotechnology 80 (2003): 115-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037712741&partnerID=MN8TOARS. Gonçalves, A.M.D.; Aires-Barros, M.R.; Cabral, J.M.S.. "Interaction of an anionic surfactant with a recombinant cutinase from Fusarium solani pisi: A spectroscopic study". Enzyme and Microbial Technology 32 7 (2003): 868-879. http://www.scopus.com/inward/record.url?eid=2-s2.0-17644440298&partnerID=MN8TOARS. 10.1016/S0141-0229(03)00054-1 Ferreira, H.A.; Graham, D.L.; Freitas, P.P.; Cabral, J.M.S.. "Biodetection using magnetically labeled biomolecules and arrays of spin valve sensors (invited)". Journal of Applied Physics 93 10 2 (2003): 7281-7286. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038313051&partnerID=MN8TOARS. 10.1063/1.1544449 Baptista, R.P.; Santos, A.M.; Fedorov, A.; Martinho, J.M.G.; Pichot, C.; Elaïssari, A.; Cabral, J.M.S.; Taipa, M.A.. "Activity, conformation and dynamics of cutinase adsorbed on poly(methyl methacrylate) latex particles". Journal of Biotechnology 102 3 (2003): 241-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037688019&partnerID=MN8TOARS. 10.1016/S0168-1656(03)00033-6 Fernandes, P.; Cruz, A.; Angelova, B.; Pinheiro, H.M.; Cabral, J.M.S.. "Microbial conversion of steroid compounds: Recent developments". Enzyme and Microbial Technology 32 6 (2003): 688-705. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037457699&partnerID=MN8TOARS. 10.1016/S0141-0229(03)00029-2 Graham, D.L.; Ferreira, H.A.; Freitas, P.P.; Cabral, J.M.S.. "High sensitivity detection of molecular recognition using magnetically labelled biomolecules and magnetoresistive sensors". Biosensors and Bioelectronics 18 4 (2003): 483-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-0642279487&partnerID=MN8TOARS. 10.1016/S0956-5663(02)00205-1 Albranches, E.; Bekman, E.; Henrique, D.; Cabral, J.M.S.. "Expansion and neural differentiation of embryonic stem cells in adherent and suspension cultures". Biotechnology Letters 25 9 (2003): 725-730. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037680702&partnerID=MN8TOARS. 10.1023/A:1023462832608 Cabrita, G.J.M.; Ferreira, B.S.; Lobato Da Silva, C.; Gonçalves, R.; Almeida-Porada, G.; Cabral, J.M.S.. "Hematopoietic stem cells: From the bone to the bioreactor". Trends in Biotechnology 21 5 (2003): 233-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037408143&partnerID=MN8TOARS. 10.1016/S0167-7799(03)00076-3 Cunha, M.T.; Costa, M.J.L.; Calado, C.R.C.; Fonseca, L.P.; Aires-Barros, M.R.; Cabral, J.M.S.. "Integration of production and aqueous two-phase systems extraction of extracellular Fusarium solani pisi cutinase fusion proteins". Journal of Biotechnology 100 1 (2003): 55-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037426677&partnerID=MN8TOARS. 10.1016/S0168-1656(02)00225-0 Fernandes, P.; Vidinha, P.; Ferreira, T.; Silvestre, H.; Cabral, J.M.S.; Prazeres, D.M.F.. "Use of free and immobilized Pseudomonas putida cells for the reduction of a thiophene derivative in organic media". Journal of Molecular Catalysis B: Enzymatic 19-20 (2002): 353-361. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037010712&partnerID=MN8TOARS. 10.1016/S1381-1177(02)00186-8 Cláudia Sousa, A.; Cabral, J.M.S.; Mateus, M.. "Microfiltration of cutinase and Escherichia coli cell fragment suspensions. The role of the electrolyte environment on the development of dynamic cake layers". Journal of Membrane Science 207 2 (2002): 171-187. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037105921&partnerID=MN8TOARS. 10.1016/S0376-7388(02)00173-4 Serralha, F.N.; Lopes, J.M.; Aires-Barros, M.R.; Prazeres, D.M.F.; Cabral, J.M.S.; Lemos, F.; Ramôa Ribeiro, F.. "Stability of a recombinant cutinase immobilized on zeolites". Enzyme and Microbial Technology 31 1-2 (2002): 29-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036644004&partnerID=MN8TOARS. 10.1016/S0141-0229(02)00068-6 Calado, C.R.C.; Taipa, M.A.; Cabral, J.M.S.; Fonseca, L.P.. "Optimisation of culture conditions and characterisation of cutinase produced by recombinant Saccharomyces cerevisiae". Enzyme and Microbial Technology 31 1-2 (2002): 161-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036644010&partnerID=MN8TOARS. 10.1016/S0141-0229(02)00084-4 Chaves, A.C.; Silveira, E.; Bezerra, R.P.; Moreira, K.A.; Lucena-Silva, N.L.C.; Abath, F.G.C.; Porto, A.L.F.; Cabral, J.M.S.; Lima-Filho, J.L.. "Influence of partition parameters on a recombinant antigen of Schistosoma mansoni expressed on E. coli using poly(ethylene glycol)-hydroxypropyl starch aqueous two-phase system". World Journal of Microbiology and Biotechnology 18 7 (2002): 645-648. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036786957&partnerID=MN8TOARS. 10.1023/A:1016887617041 Calado, C.R.C.; Mannesse, M.; Egmond, M.; Cabral, J.M.S.; Fonseca, L.P.. "Production of wild-type and peptide fusion cutinases by recombinant Saccharomyces cerevisiae MM01 strains". Biotechnology and Bioengineering 78 6 (2002): 692-698. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037142383&partnerID=MN8TOARS. 10.1002/bit.10252 Fonseca, L.P.; Cabral, J.M.S.. "An integrated downstream processing strategy for the recovery and partial purification of penicillin acylase from crude media". Journal of Chemical Technology and Biotechnology 77 10 (2002): 1176-1185. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036799856&partnerID=MN8TOARS. 10.1002/jctb.696 Ferreira, H.A.; Graham, D.L.; Bernardo, J.; Freitas, P.P.; Cabral, J.M.S.. "New biochip development based on the detection of single superparamagnetic microspheres using integrated spin valve sensors". Digests of the Intermag Conference (2002): http://www.scopus.com/inward/record.url?eid=2-s2.0-0036912481&partnerID=MN8TOARS. Calado, C.R.C.; Cabral, J.M.S.; Fonseca, L.P.. "Effect of Saccharomyces cerevisiae fermentation conditions on expanded bed adsorption of heterologous cutinase". Journal of Chemical Technology and Biotechnology 77 11 (2002): 1231-1237. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036829356&partnerID=MN8TOARS. 10.1002/jctb.695 Calado, C.R.C.; Monteiro, S.M.S.; Cabral, J.M.S.; Fonseca, L.P.. "Effect of pre-fermentation on the production of cutinase by a recombinant Saccharomyces cerevisiae". Journal of Bioscience and Bioengineering 93 4 (2002): 354-359. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036361599&partnerID=MN8TOARS. 10.1016/S1389-1723(02)80067-6 Ribeiro, S.C.; Monteiro, G.A.; Cabral, J.M.S.; Prazeres, D.M.F.. "Isolation of plasmid DNA from cell lysates by aqueous two-phase systems". Biotechnology and Bioengineering 78 4 (2002): 376-384. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037141575&partnerID=MN8TOARS. 10.1002/bit.10227 Graham, D.L.; Ferreira, H.; Bernardo, J.; Freitas, P.P.; Cabral, J.M.S.. "Single magnetic microsphere placement and detection on-chip using current line designs with integrated spin valve sensors: Biotechnological applications". Journal of Applied Physics 91 10 I (2002): 7786-7788. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037094859&partnerID=MN8TOARS. 10.1063/1.1451898 Rodrigues, Á.R.; Cabral, J.M.S.; Taipa, M.Â.. "Immobilization of Chromobacterium viscosum lipase on Eudragit S-100: Coupling, characterization and kinetic application in organic and biphasic media". Enzyme and Microbial Technology 31 1-2 (2002): 133-141. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036643977&partnerID=MN8TOARS. 10.1016/S0141-0229(02)00087-X Fonseca, L.P.; Cabral, J.M.S.. "Penicillin acylase release from Escherichia coli cells by mechanical cell disruption and permeabilization". Journal of Chemical Technology and Biotechnology 77 2 (2002): 159-167. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036161212&partnerID=MN8TOARS. 10.1002/jctb.541 Dias, A.C.P.; Fernandes, P.; Cabral, J.M.S; Pinheiro, H.M. "Isolation of a biodegradable sterol-rich fraction from industrial wastes". Bioresource Technology 82 3 (2002): 253-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036151078&partnerID=MN8TOARS. 10.1016/S0960-8524(01)00187-0 León, R.; Prazeres, D.M.F.; Molinari, F.; Cabral, J.M.S.. "Microbial stereoselective oxidation of 2-methyl-1,3-propanediol to (R)-ß-hydroxyisobutyric acid in aqueous/organic biphasic systems". Biocatalysis and Biotransformation 20 3 (2002): 201-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036117613&partnerID=MN8TOARS. 10.1080/10242420290020723 Qin, Y.; Cabral, J.M.S.. "Properties and applications of urease". Biocatalysis and Biotransformation 20 1 (2002): 1-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036184268&partnerID=MN8TOARS. 10.1080/10242420210154 Carneiro-da-Cunha, M.G.; Rocha, J.M.S.; Cabral, J.M.S.; Gil, M.H.; Garcia, F.A.P.. "Covalent immobilisation of lipase on different supports". Latin American Applied Research 32 1 (2002): 69-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036352302&partnerID=MN8TOARS. Cruz, A.; Fernandes, P.; Cabral, J.M.S.; Pinheiro, H.M.. "Effect of phase composition on the whole-cell bioconversion of ß-sitosterol in biphasic media". Journal of Molecular Catalysis B: Enzymatic 19-20 (2002): 371-375. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037010729&partnerID=MN8TOARS. 10.1016/S1381-1177(02)00188-1 Marcos, J.C.; Fonseca, L.P.; Ramalho, M.T.; Cabral, J.M.S.. "Application of surface response analysis to the optimization of penicillin acylase purification in aqueous two-phase systems". Enzyme and Microbial Technology 31 7 (2002): 1006-1014. http://www.scopus.com/inward/record.url?eid=2-s2.0-2242485605&partnerID=MN8TOARS. 10.1016/S0141-0229(02)00230-2 Calado, C.R.C.; Hamilton, G.E.; Cabral, J.M.S.; Fonseca, L.P.; Lyddiatt, A.. "Direct product sequestration of a recombinant cutinase from batch fermentations of Saccharomyces cerevisiae". Bioseparation 10 1-3 (2001): 87-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035543887&partnerID=MN8TOARS. 10.1023/A:1012464218516 Oliveira, A.C.; Rosa, M.F.; Aires-Barros, M.R.; Cabral, J.M.S.. "Enzymatic esterification of ethanol and oleic acid - A kinetic study". Journal of Molecular Catalysis - B Enzymatic 11 4-6 (2001): 999-1005. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035931385&partnerID=MN8TOARS. 10.1016/S1381-1177(00)00039-4 Llanes, N.; Fernandes, P.; Léon, R.; Cabral, J.M.S.; Pinheiro, H.M.. "Conversion of ß-sitosterol by Mycobacterium sp. NRRL B-3805 cells immobilized on Celite supports". Journal of Molecular Catalysis - B Enzymatic 11 4-6 (2001): 523-530. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035931607&partnerID=MN8TOARS. 10.1016/S1381-1177(00)00010-2 Serralha, F.N.; Lopes, J.M.; Lemos, F.; Prazeres, D.M.F.; Aires-Barros, M.R.; Cabral, J.M.S.; Ramôa Ribeiro, F.. "Kinetics and modelling of an alcoholysis reaction catalyzed by cutinase immobilized on NaY zeolite". Journal of Molecular Catalysis - B Enzymatic 11 4-6 (2001): 713-718. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035931488&partnerID=MN8TOARS. 10.1016/S1381-1177(00)00050-3 Carvalho, C.M.L.; Aires-Barros, M.R.; Cabral, J.M.S.. "A continuous membrane bioreactor for ester synthesis in organic media: II. Modeling of MBR continuous operation". Biotechnology and Bioengineering 72 2 (2001): 136-143. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035819405&partnerID=MN8TOARS. 10.1002/1097-0290(20000120)72:2<136::AID-BIT2>3.0.CO;2-2 Carvalho, C.M.L.; Aires-Barros, M.R.; Cabral, J.M.S.. "A continuous membrane bioreactor for ester synthesis in organic media: I. Operational characterization and stability". Biotechnology and Bioengineering 72 2 (2001): 127-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035819414&partnerID=MN8TOARS. 10.1002/1097-0290(20010120)72:2<127::AID-BIT1>3.0.CO;2-2 Cabral, J.; Prazeres, D.M.. "Editorial: The Second International Conference on Protein Stabilisation, 9-12 April 2000, Lisbon". Biocatalysis and Biotransformation 19 5-6 (2001): http://www.scopus.com/inward/record.url?eid=2-s2.0-0035213735&partnerID=MN8TOARS. Cruz, A.; Fernandes, P.; Cabral, J.M.S.; Pinheiro, H.M.. "Whole-cell bioconversion of ß-sitosterol in aqueous-organic two-phase systems". Journal of Molecular Catalysis - B Enzymatic 11 4-6 (2001): 579-585. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035931532&partnerID=MN8TOARS. 10.1016/S1381-1177(00)00047-3 Azevedo, A.M.; Fonseca, L.P.; Graham, D.L.; Cabral, J.M.S.; Prazeres, D.M.F.. "Behaviour of horseradish peroxidase in AOT reversed micelles". Biocatalysis and Biotransformation 19 3 (2001): 213-233. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034925825&partnerID=MN8TOARS. Melo, E.P.; Aires-Barros, M.R.; Cabral, J.M.S.. "Reverse micelles and protein biotechnology". Biotechnology Annual Review 7 (2001): 87-129. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035237050&partnerID=MN8TOARS. 10.1016/S1387-2656(01)07034-X Amaral, J.; Inganäs, M.; Cabral, J.; Prazeres, D.. "Study on the scale-up of human IgG3 purification using protein A affinity chromatography.". Bioseparation 10 4-5 (2001): 139-143. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035552335&partnerID=MN8TOARS. Azevedo, A.M.; Prazeres, D.M.F.; Cabral, J.M.S.; Fonseca, L.P.. "Stability of free and immobilised peroxidase in aqueous-organic solvents mixtures". Journal of Molecular Catalysis - B Enzymatic 15 4-6 (2001): 147-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035501590&partnerID=MN8TOARS. 10.1016/S1381-1177(01)00017-0 Teles, F.R.R.; Cabral, J.M.S.; Santos, J.A.L.. "Enzymatic degreasing of a solid waste from the leather industry by lipases". Biotechnology Letters 23 14 (2001): 1159-1163. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034865296&partnerID=MN8TOARS. 10.1023/A:1010596206857 Prazeres, D.M.F.; Monteiro, G.A.; Ferreira, G.N.M.; Diogo, M.M.; Ribeiro, S.C.; Cabral, J.M.S.. "Purification of plasmids for gene therapy and DNA vaccination". Biotechnology Annual Review 7 (2001): 1-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035237628&partnerID=MN8TOARS. 10.1016/S1387-2656(01)07031-4 Mergulhão, F.J.M.; Monteiro, G.A.; Cabral, J.M.S.; Taipa, M.A.. "A quantitative ELISA for monitoring the secretion of ZZ-fusion proteins using SpA domain as immunodetection reporter system". Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology 19 3 (2001): 239-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035168991&partnerID=MN8TOARS. 10.1385/MB:19:3:239 León, R.; Prazeres, D.M.F.; Fernandes, P.; Molinari, F.; Cabral, J.M.S.. "A multiphasic hollow fiber reactor for the whole-cell bioconversion of 2-methyl-1,3-propanediol to (R)-ß-hydroxyisobutyric acid". Biotechnology Progress 17 3 (2001): 468-473. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034970887&partnerID=MN8TOARS. 10.1021/bp010015g Queiroz, J.A.; Tomaz, C.T.; Cabral, J.M.S.. "Hydrophobic interaction chromatography of proteins". Journal of Biotechnology 87 2 (2001): 143-159. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035805436&partnerID=MN8TOARS. 10.1016/S0168-1656(01)00237-1 Domingues, F.C.; Queiroz, J.A.; Cabral, J.M.S.; Fonseca, L.P.. "Production of cellulases in batch culture using a mutant strain of Trichoderma reesei growing on soluble carbon source". Biotechnology Letters 23 10 (2001): 771-775. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034985126&partnerID=MN8TOARS. 10.1023/A:1010329731010 Cabral, J.M.S.. "Ex vivo expansion of hematopoietic stem cells in bioreactors". Biotechnology Letters 23 10 (2001): 741-751. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034989048&partnerID=MN8TOARS. 10.1023/A:1010350215989 Melo, E.P.; Faria, T.Q.; Martins, L.O.; Gonalves, A.M.; Cabral, J.M.S.. "Cutinase unfolding and stabilization by trehalose and mannosylglycerate". Proteins: Structure, Function and Genetics 42 4 (2001): 542-552. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035282963&partnerID=MN8TOARS. 10.1002/1097-0134(20010301)42:4<542::AID-PROT120>3.0.CO;2-4 Borreguero, I.; Carvalho, C.M.L.; Cabral, J.M.S.; Sinisterra, J.V.; Alcántara, A.R.. "Enantioselective properties of Fusarium solani pisi cutinase on transesterification of acyclic diols: activity and stability evaluation". Journal of Molecular Catalysis - B Enzymatic 11 4-6 (2001): 613-622. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035931506&partnerID=MN8TOARS. 10.1016/S1381-1177(00)00072-2 Serralha, F.N.; Lopes, J.M.; Vieira Ferreira, L.F.; Lemos, F.; Prazeres, D.M.F.; Aires-Barros, M.R.; Cabral, J.M.S.; Ramôa Ribeiro, F.. "Conformational changes induced by immobilization of a recombinant cutinase on zeolites". Catalysis Letters 73 1 (2001): 63-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038227096&partnerID=MN8TOARS. 10.1023/A:1016660913912 Cristina Oliveira, A.; Fernanda Rosa, M.; Cabral, J.M.S.; Raquel Aires-Barros, M.. "Effect of extraction and enzymatic esterification of ethanol on glucose consumption by two Saccharomyces cerevisiae strains: A comparative study". Journal of Chemical Technology and Biotechnology 76 3 (2001): 285-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035119408&partnerID=MN8TOARS. 10.1002/jctb.382 Serralha, F.N.; Lopes, J.M.; Lemos, F.; Prazeres, D.; Aires-Barros, M.; Rocha, J.; Cabral, J.; Ribeiro, F.R.. "Titanosilicates as supports for an enzymatic alcoholysis reaction". Reaction Kinetics and Catalysis Letters 69 2 (2000): 217-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-0007679927&partnerID=MN8TOARS. Carvalho, C.M.L.; Aires-Barros, M.R.; Cabral, J.M.S.. "Kinetics of cutinase catalyzed transesterification in AOT reversed micelles: Modeling of a batch stirred tank reactor". Journal of Biotechnology 81 1 (2000): 1-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034725958&partnerID=MN8TOARS. 10.1016/S0168-1656(00)00260-1 Ferreira, G.N.M.; Monteiro, G.A.; Prazeres, D.M.F.; Cabral, J.M.S.. "Downstream processing of plasmid DNA for gene therapy and DNA vaccine applications". Trends in Biotechnology 18 9 (2000): 380-388. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034284422&partnerID=MN8TOARS. 10.1016/S0167-7799(00)01475-X Melo, E.P.; Fojan, P.; Cabral, J.M.S.; Petersen, S.B.. "Dynamic light scattering of cutinase in AOT reverse micelles". Chemistry and Physics of Lipids 106 2 (2000): 181-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033897324&partnerID=MN8TOARS. 10.1016/S0009-3084(00)00152-3 Ferreira, G.N.M.; Cabral, J.M.S.; Prazeres, D.M.F.. "Anion exchange purification of plasmid DNA using expanded bed adsorption". Bioseparation 9 1 (2000): 1-6. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034078460&partnerID=MN8TOARS. 10.1023/A:1008134822673 Carvalho, C.M.L.; Aires-Barros, M.R.; Cabral, J.M.S.. "Integrated model for enzymatic reactions in reverse micellar systems: Nominal and effective substrate concentrations". Langmuir 16 7 (2000): 3082-3092. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033892534&partnerID=MN8TOARS. 10.1021/la991008t León, R.; Molinari, F.; Prazeres, D.M.F.; Cabral, J.M.S.. "Organic media selection for the extraction of ß-hydroxyisobutyric acid produced by microbial biotransformation". Journal of Chemical Technology and Biotechnology 75 7 (2000): 617-624. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034235833&partnerID=MN8TOARS. 10.1002/1097-4660(200007)75:7<617::AID-JCTB110>3.0.CO;2-1 Ferreira, G.N.M.; Cabral, J.M.S.; Prazeres, D.M.F.. "Studies on the batch adsorption of plasmid DNA onto anion-exchange chromatographic supports". Biotechnology Progress 16 3 (2000): 416-424. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034080617&partnerID=MN8TOARS. 10.1021/bp0000196 Ribeiro, S.C.; Monteiro, G.A.; Martinho, G.; Cabral, J.M.S.; Prazeres, D.M.F.. "Quantitation of plasmid DNA in aqueous two-phase systems by fluorescence analysis". Biotechnology Letters 22 13 (2000): 1101-1104. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033943770&partnerID=MN8TOARS. 10.1023/A:1005610113677 Oliveira, A.C.; Rosa, M.F.; Aires-Barros, M.R.; Cabral, J.M.S.. "Enzymatic esterification of ethanol by an immobilised Rhizomucor miehei lipase in a perforated rotating disc bioreactor". Enzyme and Microbial Technology 26 5-6 (2000): 446-450. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034003072&partnerID=MN8TOARS. 10.1016/S0141-0229(99)00185-4 Carvalho, C.M.L.; Cunnah, P.; Aires-Barros, M.R.; Cabral, J.M.S.. "Performance of a membrane bioreactor for enzymatic transesterification: Characterization and comparison with a batch stirred tank reactor". Biocatalysis and Biotransformation 18 1 (2000): 31-57. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034001597&partnerID=MN8TOARS. Porto, A.L.F.; Sarubbo, L.A.; Lima-Filho, J.L.; Aires-Barros, M.R.; Cabral, J.M.S.; Tambourgi, E.B.. "Hydrodynamics and mass transfer in aqueous two-phase protein extraction using a continuous perforated rotating disc contactor". Bioprocess Engineering 22 3 (2000): 215-218. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034076969&partnerID=MN8TOARS. Domingues, F.C.; Queiroz, J.A.; Cabral, J.M.S.; Fonseca, L.P.. "The influence of culture conditions on mycelial structure and cellulase production by Trichoderma reesei Rut C-30". Enzyme and Microbial Technology 26 5-6 (2000): 394-401. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034002738&partnerID=MN8TOARS. 10.1016/S0141-0229(99)00166-0 Costa, M.J.L.; Cunha, M.T.; Cabral, J.M.S.; Aires-Barros, M.R.. "Scale-up of recombinant cutinase recovery by whole broth extraction with PEG-phosphate aqueous two-phase". Bioseparation 9 4 (2000): 231-238. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034468230&partnerID=MN8TOARS. 10.1023/A:1008162209596 Melo, E.P.; Taipa, M.A.; Castellar, M.R.; Costa, S.M.B.; Cabral, J.M.S.. "A spectroscopic analysis of thermal stability of the Chromobacterium viscosum lipase". Biophysical Chemistry 87 2-3 (2000): 111-120. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034735624&partnerID=MN8TOARS. 10.1016/S0301-4622(00)00171-X Teresa Cunha, M.; Cabral, J.M.S.; Tjerneld, F.; Raquel Aires-Barros, M.. "Effect of salts and surfactants on the partitioning of fusarium solani pisi cutinase in aqueous two-phase systems of thermoseparating ethylene oxide/propylene oxide random copolymer and hydroxypropyl starch". Bioseparation 9 4 (2000): 203-209. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034468013&partnerID=MN8TOARS. 10.1023/A:1008132108117 Baptista, R.P.; Cabral, J.M.S.; Melo, E.P.. "Trehalose delays the reversible but not the irreversible thermal denaturation of cutinase". Biotechnology and Bioengineering 70 6 (2000): 699-703. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034694819&partnerID=MN8TOARS. 10.1002/1097-0290(20001220)70:6<699::AID-BIT13>3.0.CO;2-N Carvalho, C.M.L; Cabral, J.M.S. "Reverse micelles as reaction media for lipases". Biochimie 82 11 (2000): 1063-1085. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033652902&partnerID=MN8TOARS. 10.1016/S0300-9084(00)01187-1 Chaves, A.C.; Lucena-Silva, N.; Abath, F.G.C.; Pereira, V.R.A.; Lima-Filho, J.L.; Porto, A.L.F.; Cabral, J.M.S.. "Liquid-liquid extraction of a Schistosoma mansoni recombinant protein from an Escherichia coli extract in aqueous two-phase system". Bioprocess Engineering 23 5 (2000): 435-438. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033675501&partnerID=MN8TOARS. Gonçalves, A.M.; Serro, A.P.; Aires-Barros, M.R.; Cabral, J.M.S.. "Effects of ionic surfactants used in reversed micelles on cutinase activity and stability". Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology 1480 1-2 (2000): 92-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-0343953095&partnerID=MN8TOARS. 10.1016/S0167-4838(00)00093-5 Pires Cabral, P.M.N.A.C.; Lima Costa, M.E.; Cabral, J.M.S.. "A structured growth model for cynara cardunculus cell suspension". Bioprocess Engineering 23 2 (2000): 199-203. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033865849&partnerID=MN8TOARS. Ferreira, G.N.M.; Cabral, J.M.S.; Prazeres, D.M.F.. "Development of process flow sheets for the purification of supercoiled plasmids for gene therapy applications". Biotechnology Progress 15 4 (1999): 725-731. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033167256&partnerID=MN8TOARS. 10.1021/bp990065+ Carvalho, C.M.L.; Cabral, J.M.S.; Aires-Barros, M.R.. "Cutinase stability in AOT reversed micelles: System optimization using the factorial design methodology". Enzyme and Microbial Technology 24 8-9 (1999): 569-576. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032920502&partnerID=MN8TOARS. 10.1016/S0141-0229(98)00163-X Serralheiro, M.L.M.; Prazeres, D.M.F.; Cabral, J.M.S.. "Continuous production and simultaneous precipitation of a dipeptide in a reversed micellar membrane reactor". Enzyme and Microbial Technology 24 8-9 (1999): 507-513. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032944832&partnerID=MN8TOARS. 10.1016/S0141-0229(98)00141-0 Carvalho, C.M.L.; Aires-Barros, M.R.; Cabral, J.M.S.. "Cutinase: From molecular level to bioprocess development". Biotechnology and Bioengineering 66 1 (1999): 17-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033230644&partnerID=MN8TOARS. 10.1002/(SICI)1097-0290(1999)66:1<17::AID-BIT2>3.0.CO;2-F Monteiro, G.A.; Ferreira, G.N.M.; Cabral, J.M.S.; Prazeres, D.M.F.. "Analysis and use of endogenous nuclease activities in Escherichia coil lysates during the primary isolation of plasmids for gene therapy". Biotechnology and Bioengineering 66 3 (1999): 189-194. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033454713&partnerID=MN8TOARS. 10.1002/(SICI)1097-0290(1999)66:3<189::AID-BIT7>3.0.CO;2-Z Diogo, M.M.; Silva, S.; Cabral, J.M.S.; Queiroz, J.A.. "Hydrophobic interaction chromatography of Chromobacterium viscosum lipase on polypropylene glycol immobilised on Sepharose". Journal of Chromatography A 849 2 (1999): 413-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033062863&partnerID=MN8TOARS. 10.1016/S0021-9673(99)00619-6 Carvalho, C.M.L.; Melo, E.P.; Costa, S.M.B.; Cabral, J.M.S.; Aires-Barros, M.R.. "A steady-state fluorescence study of cutinase microencapsulated in AOT reversed micelles at optimal stability conditions". Biotechnology Letters 21 8 (1999): 673-681. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032830485&partnerID=MN8TOARS. 10.1023/A:1005550213632 Marcos, J.C.; Fonseca, L.P.; Ramalho, M.T.; Cabral, J.M.S.. "Partial purification of penicillin acylase from Escherichia coli in poly(ethylene glycol)-sodium citrate aqueous two-phase systems". Journal of Chromatography B: Biomedical Sciences and Applications 734 1 (1999): 15-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032877729&partnerID=MN8TOARS. 10.1016/S0378-4347(99)00319-9 Prazeres, D.M.F.; Ferreira, G.N.M.; Monteiro, G.A.; Cooney, C.L.; Cabral, J.M.S.. "Large-scale production of pharmaceutical-grade plasmid DNA for gene therapy: Problems and bottlenecks". Trends in Biotechnology 17 4 (1999): 169-174. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033120652&partnerID=MN8TOARS. 10.1016/S0167-7799(98)01291-8 Ferreira, G.N.M.; Cabral, J.M.S.; Prazeres, D.M.F.. "Monitoring of process streams in the large-scale production and purification of plasmid DNA for gene therapy applications". Pharmacy and Pharmacology Communications 5 1 (1999): 57-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032968972&partnerID=MN8TOARS. Serralheiro, M.L.M.; Cabral, J.M.S.. "Thermal stability of a-chymotrypsin, native and chemically modified, inside reverse micelles during peptide synthesis". Biocatalysis and Biotransformation 17 1 (1999): 3-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032895654&partnerID=MN8TOARS. Gonçalves, A.M.; Schacht, E.; Matthijs, G.; Aires Barros, M.R.; Cabral, J.M.S.; Gil, M.H.. "Stability studies of a recombinant cutinase immobilized to dextran and derivatized silica supports". Enzyme and Microbial Technology 24 1-2 (1999): 60-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342459772&partnerID=MN8TOARS. 10.1016/S0141-0229(98)00089-1 Mergulhão, F.J.M.; Kelly, A.G.; Monteiro, G.A.; Taipa, M.A.; Cabral, J.M.S.. "Troubleshooting in gene splicing by overlap extension: A step-wise method". Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology 12 3 (1999): 285-287. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033428016&partnerID=MN8TOARS. Fonseca, L.P.; Cabral, J.M.S.. "Optimization of a pseudo-affinity process for penicillin acylase purification". Bioprocess Engineering 20 6 (1999): 513-524. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033021877&partnerID=MN8TOARS. 10.1007/s004490050623 Serralheiro, M.L.M.; Cabral, J.M.S.. "Irreversible thermoinactivation of a-chymotrypsin in buffer and water miscible organic solvent. Comparison with a reverse micellar system". Journal of Molecular Catalysis - B Enzymatic 7 1-4 (1999): 191-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032820347&partnerID=MN8TOARS. 10.1016/S1381-1177(99)00029-6 Krieger, N.; Taipa, M.A.; Melo, E.H.M.; Lima-Filho, J.L.; Aires-Barros, M.R.; Cabral, J.M.S.. "Purification of a Penicillium citrinum lipase by chromatographic processes". Bioprocess Engineering 20 1 (1999): 59-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033003342&partnerID=MN8TOARS. 10.1007/s004490050560 Chaves, A.C.; Abath, F.G.C.; Lima-Filho, J.L.; Cabral, J.M.S.; Lucena-Silva, N.. "Studies on growth kinetics and plasmid stability of a recombinant Escherichia coil expressing a Schistosoma mansoni antigen". Bioprocess Engineering 21 4 (1999): 355-361. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032845328&partnerID=MN8TOARS. 10.1007/s004490050687 Fernandes, P.; Cabral, J.M.S.; Pinheiro, H.M.. "Stability of free and immobilized Mycobacterium sp. cells in aqueous and organic media". Progress in Biotechnology 15 C (1998): 625-630. http://www.scopus.com/inward/record.url?eid=2-s2.0-0008605558&partnerID=MN8TOARS. 10.1016/S0921-0423(98)80093-2 Fontes, N.; Almeida, M.C.; Garcia, S.; Peres, C.; Grave, J.; Aires-Barros, M.R.; Soares, C.M.; et al. "Cutinase activity and enantioselectivity in supercritical fluids". Progress in Biotechnology 15 C (1998): 483-486. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957057279&partnerID=MN8TOARS. 10.1016/S0921-0423(98)80072-5 Gonçalves, A.P.V.; Cabral, J.M.S.; Aires-Barros, M.R.. "Analysis of a BSTR reactor for triglyceride hydrolysis with an immobilised cutinase". Journal of Molecular Catalysis - B Enzymatic 5 1-4 (1998): 35-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032530506&partnerID=MN8TOARS. 10.1016/S1381-1177(98)00099-X León, R.; Fernandes, P.; Pinheiro, H.M.; Cabral, J.M.S.. "Whole-cell biocatalysis in organic media". Enzyme and Microbial Technology 23 7-8 (1998): 483-500. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041981949&partnerID=MN8TOARS. 10.1016/S0141-0229(98)00078-7 Carvalho, C.M.L.; Cabral, J.M.S.; Aires-Barros, M.R.. "Kinetics and modelling of transesterification reactions catalysed by cutinase in AOT reversed micelles". Journal of Molecular Catalysis - B Enzymatic 5 1-4 (1998): 361-365. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032530874&partnerID=MN8TOARS. 10.1016/S1381-1177(98)00098-8 Oliveira, A.C.; Rosa, M.F.; Cabral, J.M.S.; Aires-Barros, M.R.. "Improvement of alcoholic fermentations by simultaneous extraction and enzymatic esterification of ethanol". Journal of Molecular Catalysis - B Enzymatic 5 1-4 (1998): 29-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032530418&partnerID=MN8TOARS. 10.1016/S1381-1177(98)00096-4 Serralha, F.N.; Lopes, J.M.; Lemos, F.; Prazeres, D.M.F.; Aires-Barros, M.R.; Cabral, J.M.S.; Ramôa Ribeiro, F.. "Zeolites as supports for an enzymatic alcoholysis reaction". Journal of Molecular Catalysis - B Enzymatic 4 5-6 (1998): 303-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032479932&partnerID=MN8TOARS. 10.1016/S1381-1177(98)00069-1 Qin, Y.; Cabral, J.M.S.. "Theoretical analysis on the design of hollow fiber modules and modules cascades for the separation of diluted species". Journal of Membrane Science 143 1-2 (1998): 197-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032572067&partnerID=MN8TOARS. 10.1016/S0376-7388(98)00007-6 Melo, E.P.; Carvalho, C.M.L.; Aires-Barros, M.R.; Costa, S.M.B.; Cabral, J.M.S.. "Deactivation and conformational changes of cutinase in reverse micelles". Biotechnology and Bioengineering 58 4 (1998): 380-386. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032550831&partnerID=MN8TOARS. 10.1002/(SICI)1097-0290(19980520)58:4<380::AID-BIT5>3.0.CO;2-F Marcos, J.C.; Fonseca, L.P.; Ramalho, M.T.; Cabral, J.M.S.. "Variation of penicillin acylase partition coefficient with phase volume ratio in poly(ethylene glycol)-sodium citrate aqueous two-phase systems". Journal of Chromatography B: Biomedical Applications 711 1-2 (1998): 295-299. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032568992&partnerID=MN8TOARS. 10.1016/S0378-4347(97)00633-6 Cunha, M.T.; Tjerneld, F.; Cabral, J.M.S.; Maria Raquel Aires-Barros. "Effect of electrolytes and surfactants on the thermoseparation of an ethylene oxide-propylene oxide random copolymer in aqueous solution". Journal of Chromatography B: Biomedical Applications 711 1-2 (1998): 53-60. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032569067&partnerID=MN8TOARS. 10.1016/S0378-4347(98)00021-8 Qin, Y.; Cabral, J.M.S.. "Lumen Mass Transfer in Hollow-Fiber Membrane Processes with Nonlinear Boundary Conditions". AIChE Journal 44 4 (1998): 836-848. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032046569&partnerID=MN8TOARS. Diogo, M.M.; Cabral, J.M.S.; Queiroz, J.A.. "Preliminary study on hydrophobic interaction chromatography of Chromobacterium viscosum lipase on polypropylene glycol immobilized on Sepharose". Journal of Chromatography A 796 1 (1998): 177-180. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032512744&partnerID=MN8TOARS. 10.1016/S0021-9673(97)01059-5 Carvalho, C.M.L.; Aires-Barros, M.R.; Cabral, J.M.S.. "Cutinase structure, function and biocatalytic applications". Electronic Journal of Biotechnology 1 3 (1998): 91-113. http://www.scopus.com/inward/record.url?eid=2-s2.0-0343024606&partnerID=MN8TOARS. Taipa, M.A.; Kaul, R.; Mattiasson, B.; Cabral, J.M.S.. "Preliminary studies on the purification of a monoclonal antibody by affinity precipitation with Eudragit S-100". Journal of Molecular Recognition 11 1-6 (1998): 240-242. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032457255&partnerID=MN8TOARS. Fernandes, P.; Cabral, J.M.S.; Pinheiro, H.M.. "Influence of some operational parameters on the bioconversion of sitosterol with immobilized whole cells in organic medium". Journal of Molecular Catalysis - B Enzymatic 5 1-4 (1998): 307-310. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032530413&partnerID=MN8TOARS. 10.1016/S1381-1177(98)00057-5 Fonseca, L.J.P.; Patricio, I.M.; Cabral, J.M.S.. "Preliminary studies on continuous recovery and purification of the penicillin acylase under pseudoaffinity conditions using phenyl-Sepharose gel". Journal of Molecular Recognition 11 1-6 (1998): 252-254. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032457504&partnerID=MN8TOARS. Ferreira, G.N.M.; Cabral, J.M.S.; Prazeres, D.M.F.. "Purification of supercoiled plasmid DNA using chromatographic processes". Journal of Molecular Recognition 11 1-6 (1998): 250-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032448825&partnerID=MN8TOARS. Qin, Y.; Cabral, J.M.S.. "Influence of Nernst-Planck diffusion on hollow-fiber mass-transfer processes". AIChE Journal 44 7 (1998): 1529-1541. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344269307&partnerID=MN8TOARS. Ferreira, G.N.M.; Cabral, J.M.S.; Prazeres, D.M.F.. "A comparison of gel filtration chromatographic supports for plasmid purification". Biotechnology Techniques 11 6 (1997): 417-420. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030968156&partnerID=MN8TOARS. Carvalho, C.M.L.; Serralheiro, M.L.M.; Cabral, J.M.S.; Aires-Barros, M.R.. "Application of factorial design to the study of transesterification reactions using cutinase in AOT-reversed micelles". Enzyme and Microbial Technology 21 2 (1997): 117-123. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031214893&partnerID=MN8TOARS. 10.1016/S0141-0229(96)00245-1 Krieger, N.; Taipa, M.A.; Aires-Barros, M.R.; Melo, E.H.M.; Lima-Filho, J.L.; Cabral, J.M.S.. "Purification of the Penicillium citrinum lipase using AOT reversed micelles". Journal of Chemical Technology and Biotechnology 69 1 (1997): 77-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031148956&partnerID=MN8TOARS. 10.1002/(SICI)1097-4660(199705)69:1<77::AID-JCTB666>3.0.CO;2-V Cunha, M.T.; Cabral, J.M.S.; Aires-Barros, M.R.. "Quantification of phase composition in aqueous two-phase systems of Breox/Phosphate and Breox/Reppal PES 100 by isocratic HPLC". Biotechnology Techniques 11 5 (1997): 351-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030904839&partnerID=MN8TOARS. Sarmento, M.J.; Pires, M.J.; Cabral, J.M.S.; Aires-Barros, M.R.. "Liquid-liquid extraction of a recombinant protein, cytochrome b5, from an impure extract using aqueous two-phase systems". Bioprocess Engineering 16 5 (1997): 295-297. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030919844&partnerID=MN8TOARS. 10.1007/s004490050325 Krieger, N.; Taipa, M.A.; Melo, E.H.M.; Lima-Filho, J.L.; Aires-Barros, M.R.; Cabral, J.M.S.. "Kinetic Characterization of Penicillium citrinum Lipase in AOT/Isooctane-Reversed Micelles". Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology 67 1-2 (1997): 87-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842817562&partnerID=MN8TOARS. Coelho, J.A.P.; Mendes, R.L.; Provost, M.C.; Cabral, J.M.S.; Novais, J.M.; Palavra, A.M.F.. "Supercritical Carbon Dioxide Extraction of Volatile Compounds from Rosemary". ACS Symposium Series 670 (1997): 101-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-0043238172&partnerID=MN8TOARS. Sebastião, M.J.; Martel, P.; Baptista, A.; Petersen, S.B.; Cabral, J.M.S.; Aires-Barros, M.R.. "Predicting the partition coefficients of a recombinant cutinase in polyethylene glycol/phosphate aqueous two-phase systems". Biotechnology and Bioengineering 56 3 (1997): 248-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031555165&partnerID=MN8TOARS. 10.1002/(SICI)1097-0290(19971105)56:3<248::AID-BIT2>3.0.CO;2-J Feliciano, A.S.; Cabral, J.M.S.; Prazeres, D.M.F.. "Solubility studies and synthesis of AcPheLeuNH2 in reversed micellar systems". Biocatalysis and Biotransformation 14 3 (1997): 219-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030647952&partnerID=MN8TOARS. Cabral, J.M.S.; Aires-Barros, M.R.; Pinheiro, H.; Prazeres, D.M.F.. "Biotransformation in organic media by enzymes and whole cells". Journal of Biotechnology 59 1-2 (1997): 133-143. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031576709&partnerID=MN8TOARS. 10.1016/S0168-1656(97)00176-4 Molinari, F.; Aragozzini, F.; Cabral, J.M.S.; Prazeres, D.M.F.. "Continuous production of isovaleraldehyde through extractive bioconversion in a hollow-fiber membrane bioreactor". Enzyme and Microbial Technology 20 8 (1997): 604-611. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031172712&partnerID=MN8TOARS. 10.1016/S0141-0229(96)00205-0 Feliciano, A.S.; Cabral, J.M.S.; Prazeres, D.M.F.. "Quantitative structure activity relationships in the synthesis of AcXYNH2, dipeptides by a-chymotrypsin in reversed micelles". Enzyme and Microbial Technology 21 4 (1997): 284-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031239662&partnerID=MN8TOARS. 10.1016/S0141-0229(97)00043-4 Porto, A.L.F.; Lima-Filho, J.L.; Aires-Barros, M.R.; Cabral, J.M.S.; Tambourgi, E.B.. "Extraction of recombinant cytochrome b5 from disrupted Escherichia coli cells with an aqueous two-phase system in a continuous perforated rotating disc contactor". Biotechnology Techniques 11 9 (1997): 641-643. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030874790&partnerID=MN8TOARS. Qin, Y.; Cabral, J.M.S.. "Lumen Mass Transfer in Hollow-Fiber Membrane Processes with Constant External Resistances". AIChE Journal 43 8 (1997): 1975-1987. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031211650&partnerID=MN8TOARS. Gonçalves, A.P.V.; Lopes, J.M.; Lemos, F.; Ramôa Ribeiro, F.; Prazeres, D.M.F.; Cabral, J.M.S.; Aires-Barros, M.R.. "Effect of the immobilization support on the hydrolytic activity of a cutinase from Fusarium solani pisi". Enzyme and Microbial Technology 20 2 (1997): 93-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031081636&partnerID=MN8TOARS. 10.1016/S0141-0229(96)00089-0 Pinho Melo, E.; Aires-Barros, M.R.; Costa, S.M.B.; Cabral, J.M.S.. "Thermal unfolding of proteins at high pH range studied by UV absorbance". Journal of Biochemical and Biophysical Methods 34 1 (1997): 45-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031047243&partnerID=MN8TOARS. 10.1016/S0165-022X(97)01202-5 Oliveira, A.C.; Rosa, M.F.; Cabral, J.M.S.; Aires-Barros, M.R.. "Immobilization of saccharomyces cerevisiae cells and rhizomocur miehei lipase for the production and extractive biocatalysis of ethanol". Bioprocess Engineering 16 6 (1997): 349-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030920502&partnerID=MN8TOARS. 10.1007/s004490050334 Qin, Y.; Cabral, J.M.S.. "Hollow fiber supported liquid membrane process for the separation of NH3 from aqueous media containing NH3 and CO2". Journal of Chemical Technology and Biotechnology 65 2 (1996): 137-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029671530&partnerID=MN8TOARS. Belo, I.; Santos, J.A.L.; Cabral, J.M.S.; Mota, M.. "Optimization study of Escherichia coli TB1 cell disruption for cytochrome b5 recovery in a small-scale bead mill". Biotechnology Progress 12 2 (1996): 201-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030088489&partnerID=MN8TOARS. Lima Costa, M.E.; Van Gulik, W.M.; Ten Hoopen, J.G.; Pais, M.S.S.; Cabral, J.M.S.. "Protease and phenol production of Cynara cardunculus L. Cell suspension in a chemostat". Enzyme and Microbial Technology 19 7 (1996): 493-500. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030589116&partnerID=MN8TOARS. 10.1016/S0141-0229(96)00058-0 Castellar, M.R.; Taipa, M.A.; Cabral, J.M.S.. "Kinetic and stability characterization of Chromobacterium viscosum lipase and its comparison with Pseudomonas glumae lipase". Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology 61 3 (1996): 299-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000115897&partnerID=MN8TOARS. Qin, Y.; Cabral, J.M.S.; Wang, S.. "Hollow-Fiber Gas-Membrane Process for Removal of NH3 from Solution of NH3 and CO2". AIChE Journal 42 7 (1996): 1945-1956. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030199267&partnerID=MN8TOARS. Gonalves, A.P.V.; Cabral, J.M.S.; Aires-Barros, M.R.. "Immobilization of a recombinant cutinase by entrapment and by covalent binding kinetic and stability studies". Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology 60 3 (1996): 217-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030227450&partnerID=MN8TOARS. Fonseca, L.P.; Cabral, J.M.S.. "Evaluation of affinity and pseudo-affinity adsorption processes for penicillin acylase purification". Bioseparation 6 5 (1996): 293-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030428467&partnerID=MN8TOARS. Cunnah, P.J.; Aires-Barros, M.R.; Cabral, J.M.S.. "Esterification and transesterification catalysed by cutinase in reverse micelles of CTAB for the synthesis of short chain esters". Biocatalysis and Biotransformation 14 2 (1996): 125-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030413045&partnerID=MN8TOARS. Melo, E.P.; Costa, S.M.B.; Cabral, J.M.S.. "Denaturation of a recombinant cutinase from Fusarium solani in AOT-iso-octane reverse micelles: A steady-state fluorescence study". Photochemistry and Photobiology 63 2 (1996): 169-175. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030038712&partnerID=MN8TOARS. Carneiro-da-Cunha, M.G.; Melo, E.P.; Cabral, J.M.S.; Aires-Barros, M.R.. "Liquid-liquid extraction of a recombinant cutinase from fermentation media with AOT reversed micelles". Bioprocess Engineering 15 3 (1996): 151-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029763705&partnerID=MN8TOARS. 10.1007/s004490050249 Cabral, J.M.S.; Aires-Barros, M.R.. "Biocatalysis in organic media by cutinase immobilized in reversed micelles and zeolites". Chimia 50 9 (1996): 420-421. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042856687&partnerID=MN8TOARS. Qin, Y.; Cabral, J.M.S.. "Comparison between supported gas membrane process and supported liquid membrane process for the separation of NH3 from aqueous media containing NH3 and CO2". Journal of Chemical Technology and Biotechnology 67 4 (1996): 323-328. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030512688&partnerID=MN8TOARS. 10.1002/(SICI)1097-4660(199612)67:4<323::AID-JCTB581>3.0.CO;2-M Carneiro-da-Cunha, M.G.; Aires-Barros, M.R.; Tambourgi, E.B.; Cabral, J.M.S.. "Continuous extraction of a recombinant cutinase from Escherichia coli disrupted cells with reversed micelles using a perforated rotating disc contactor". Bioprocess Engineering 15 5 (1996): 253-256. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029796267&partnerID=MN8TOARS. 10.1007/s004490050264 Santos, J.A.L.; Belo, I.; Mota, M.; Cabral, J.M.S.. "Freeze/thawing and sonication of Escherichia coli TB1 cells for cytochrome b5 recovery". Bioseparation 6 2 (1996): 81-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030128904&partnerID=MN8TOARS. Queiroz, J.A.; Garcia, F.A.P.; Cabral, J.M.S.. "Hydrophobic interaction chromatography of Chromobacterium viscosum lipase on polyethylene glycol immobilized on Sepharose". Journal of Chromatography A 734 1 (1996): 213-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029933936&partnerID=MN8TOARS. 10.1016/0021-9673(95)01163-3 Sebastião, M.J.; Cabral, J.M.S.; Aires-Barros, M.R.. "Improved purification protocol of a Fusarium solani pisi recombinant cutinase by phase partitioning in aqueous two-phase systems of polyethylene glycol and phosphate". Enzyme and Microbial Technology 18 4 (1996): 251-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030111019&partnerID=MN8TOARS. 10.1016/0141-0229(95)00045-3 Morgado, M.A.P.; Cabral, J.M.S.; Prazeres, D.M.F.. "Phospholipase A2-catalyzed hydrolysis of lecithin in a continuous reversed-micellar membrane bioreactor". JAOCS, Journal of the American Oil Chemists' Society 73 3 (1996): 337-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000531929&partnerID=MN8TOARS. Molinari, F.; Aragozzini, F.; Cabral, J.M.S.; Prazeres, D.M.F.. "Continuous production and in situ extraction of isovaleraldehyde in a membrane bioreactor". Progress in Biotechnology 11 C (1996): 538-545. http://www.scopus.com/inward/record.url?eid=2-s2.0-0004929655&partnerID=MN8TOARS. 10.1016/S0921-0423(96)80074-8 Pires, M.J.; Aires-Barros, M.R.; Cabral, J.M.S.. "Liquid-liquid extraction of proteins with reversed micelles". Biotechnology Progress 12 3 (1996): 290-301. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030144987&partnerID=MN8TOARS. Fernandes, P.; Cabral, J.M.S.; Pinheiro, H.M.. "Bioconversion of a hydrocortisone derivative in an organic-aqueous two-liquid-phase system". Enzyme and Microbial Technology 17 2 (1995): 163-167. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028907925&partnerID=MN8TOARS. 10.1016/0141-0229(94)00004-B Melo, N.S.; Cabral, J.M.; Fevereiro, M.P.. "Extracellular peroxidases from cell suspension cultures of Vaccinium myrtillus. Purification and characterization of two cationic enzymes". Plant Science 106 2 (1995): 177-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029105156&partnerID=MN8TOARS. 10.1016/0168-9452(95)04078-9 Melo, E.P.; Airesbarros, M.R.; Cabral, J.M.S.. "Triglyceride hydrolysis and stability of a recombinant cutinase from Fusarium solani in AOT-iso-octane reversed micelles". Applied Biochemistry and Biotechnology 50 1 (1995): 45-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029205576&partnerID=MN8TOARS. 10.1007/BF02788039 Alves, J.R.; Fonseca, L.P.; Ramalho, M.T.; Cabral, J.M.. "Assay of penicillin acylase in organic media". Biotechnology Techniques 9 10 (1995): 729-730. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028831146&partnerID=MN8TOARS. Sebastiao, M.J.; Cabral, J.M.; Aires-Barros, M.R.. "Simultaneous quantification of polymer and salt in polyethylene glycol/phosphate aqueous two-phase systems by HPLC". Biotechnology Techniques 9 7 (1995): 503-508. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028833240&partnerID=MN8TOARS. Setti, L.; Fevereiro, P.; Melo, E.P.; Pifferi, P.G.; Cabral, J.M.S.; Aires-Barros, M.R.. "Superactivity of peroxidase solubilized in reversed micellar systems". Applied Biochemistry and Biotechnology 55 3 (1995): 207-218. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029436379&partnerID=MN8TOARS. 10.1007/BF02786860 Mateus, M.; Cabral, J.M.S.. "Modeling membrane filtration of protein and cell suspensions in a vortex flow filtration system". AIChE Journal 41 4 (1995): 764-772. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029278483&partnerID=MN8TOARS. Mendes, R.L.; Coelho, J.P.; Fernandes, H.L.; Marrucho, I.J.; Cabral, J.M.S.; Novais, J.M.; Palavra, A.F.. "Applications of supercritical CO2 extraction to microalgae and plants". Journal of Chemical Technology and Biotechnology 62 1 (1995): 53-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028980388&partnerID=MN8TOARS. 10.1002/jctb.280620108 Ribeiro, M.H.L.; Prazeres, D.M.F.; Cabral, J.M.S.; Da Fonseca, M.M.R.. "Adsorption studies for the separation of L-tryptophan from L-serine and indole in a bioconversion medium". Bioprocess Engineering 12 1-2 (1995): 95-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028896713&partnerID=MN8TOARS. 10.1007/BF01112999 Pinho Melo, E.; Ivanova, M.G.; Aires-Barros, M.R.; Cabral, J.M.S.; Verger, R.. "Glyceride synthesis catalyzed by cutinase using the monomolecular film technique". Biochemistry 34 5 (1995): 1615-1621. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028947712&partnerID=MN8TOARS. Mendes, R.L.; Fernandes, H.L.; Coelho, JosP.; Reis, E.C.; Cabral, J.M.S.; Novais, J.M.; Palavra, A.F.. "Supercritical CO2 extraction of carotenoids and other lipids from Chlorella vulgaris". Food Chemistry 53 1 (1995): 99-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028903921&partnerID=MN8TOARS. Morgado, M.A.P.; Cabral, J.M.S.; Prazeres, D.M.F.. "Hydrolysis of lecithin by phospholipase A2 in mixed reversed micelles of lecithin and sodium dioctyl sulphosuccinate". Journal of Chemical Technology and Biotechnology 63 2 (1995): 181-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029003972&partnerID=MN8TOARS. 10.1002/jctb.280630214 Melo, E.P.; Costa, S.M.B.; Cabral, J.M.S.. "Structural effect of reversed micelles of AOT over a recombinant cutinase from Fusarium solani pisi - A steady state fluorescence study". Annals of the New York Academy of Sciences 750 (1995): 85-88. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029129510&partnerID=MN8TOARS. 10.1111/j.1749-6632.1995.tb19931.x Kennedy, J.F.; Cabral, J.M.S.. "Immobilisation of biocatalysts by metal-link/chelation processes". Artificial Cells, Blood Substitutes, and Immobilization Biotechnology 23 2 (1995): 231-252. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028902474&partnerID=MN8TOARS. Alves, J.R.; Fonseca, L.P.; Ramalho, M.T.; Cabral, J.M.. "Separation and purification of penicillin acylase from Escherichia coli using AOT reverse micelles". Biotechnology Techniques 9 4 (1995): 265-270. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029137814&partnerID=MN8TOARS. Queiroz, J.A.; Garcia, F.A.P.; Cabral, J.M.S.. "Hydrophobic interaction chromatography of Chromobacterium viscosum lipase". Journal of Chromatography A 707 2 (1995): 137-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029148070&partnerID=MN8TOARS. 10.1016/0021-9673(95)00134-9 Prazeres, D.M.F.; Cabral, J.M.S.. "Enzymatic membrane bioreactors and their applications". Enzyme and Microbial Technology 16 9 (1994): 738-750. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028500530&partnerID=MN8TOARS. 10.1016/0141-0229(94)90030-2 Serralheiro, M.L.M.; Prazeres, D.M.F.; Cabral, J.M.S.. "Dipeptide synthesis and separation in a reversed micellar membrane reactor". Enzyme and Microbial Technology 16 12 (1994): 1064-1073. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028626281&partnerID=MN8TOARS. 10.1016/0141-0229(94)90144-9 Qin, Y.; Cabral, J.M.S.. "Kinetic studies of the urease-catalyzed hydrolysis of urea in a buffer-free system". Applied Biochemistry and Biotechnology 49 3 (1994): 217-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028696865&partnerID=MN8TOARS. 10.1007/BF02783059 Sarmento, M.J.; Pires, M.J.; Cabral, J.M.S.; Aires-Barros, M.R.. "Liquid-liquid extraction of a recombinant protein, cytochrome b5, with aqueous two-phase systems of polyethylene glycol and potassium phosphate salts". Journal of Chromatography A 668 1 (1994): 117-120. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028305574&partnerID=MN8TOARS. Pires, M.J.; Cabral, J.M.S.. "Thermal stability of a Desulfovibrio gigas periplasmic hydrogenase in reverse micelles". Applied Biochemistry and Biotechnology 48 3 (1994): 137-147. http://www.scopus.com/inward/record.url?eid=2-s2.0-51249163987&partnerID=MN8TOARS. 10.1007/BF02788738 Pires, M.J.; Cabral, J.M.S.. "Liquid-liquid extraction of a recombinant protein with reverse micelles". Journal of Chemical Technology and Biotechnology 61 3 (1994): 219-224. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028534144&partnerID=MN8TOARS. 10.1002/jctb.280610307 Pires, M.J.; Martel, P.; Baptista, A.; Petersen, S.B.; Willson, R.C.; Cabral, J.M.S.. "Improving protein extraction yield in reversed micellar systems through surface charge engineering". Biotechnology and Bioengineering 44 7 (1994): 773-780. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028501097&partnerID=MN8TOARS. Serralheiro, M.L.M.; Cabral, J.M.S.. "Synthesis of AcPheLeuNH2 by a-chymotrypsin in TTAB reversed micelles: Application of response surface methodology to the optimization of the system". Biotechnology and Bioengineering 43 11 (1994): 1031-1042. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028431437&partnerID=MN8TOARS. 10.1002/bit.260431106 Dias, A.C.P.; Cabral, J.M.S.; Pinheiro, H.M.. "Sterol side-chain cleavage with immobilized Mycobacterium cells in water-immiscible organic solvents". Enzyme and Microbial Technology 16 8 (1994): 708-714. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028485449&partnerID=MN8TOARS. 10.1016/0141-0229(94)90094-9 Caldeira, J.C.G.; Cabral, J.M.S.. "Extraction of a steroid 1,2 dehydrogenase by sonication of Arthrobacter simplex cells". Bioseparation 4 4 (1994): 271-278. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028485766&partnerID=MN8TOARS. Carneiro-da-Cunha, M.G.; Cabral, J.M.S.; Aires-Barros, M.R.. "Studies on the extraction and back-extraction of a recombinant cutinase in a reversed micellar extraction process". Bioprocess Engineering 11 5 (1994): 203-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027960584&partnerID=MN8TOARS. 10.1007/s004490050070 Carneiro da Cunha, M.G.; Aires-Barros, M.R.; Tambourgi, E.B.; Cabral, J.M.S.. "Recovery of a recombinant cutinase with reversed micelles in a continuous perforated rotating disc contactor". Biotechnology Techniques 8 6 (1994): 413-418. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028002457&partnerID=MN8TOARS. Prazeres, D.M.F.; Garcia, F.A.P.; Cabral, J.M.S.. "Continuous lipolysis in a reversed micellar membrane bioreactor". Bioprocess Engineering 10 1 (1994): 21-27. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028055009&partnerID=MN8TOARS. Taipa, M.A.; Moura-Pinto, P.; Cabral, J.M.S.. "Identification and characterization of Chromobacterium viscosum lipase". Biotechnology Techniques 8 1 (1994): 27-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027951269&partnerID=MN8TOARS. Fonseca, L.P.; Caldeira, J.C.G.; Cabral, J.M.S.. "Improvement in the polyethylene glycol-Cibacron Blue purification method". Journal of Chromatography A 668 1 (1994): 61-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028241251&partnerID=MN8TOARS. 10.1016/0021-9673(94)80092-8 Mendes, R.L.; Fernandes, H.L.; Coelho, J.A.P.; Cabral, J.M.S.; Palavra, A.M.F.; Novais, J.M.. "supercritical carbon dioxide extraction of hydrocarbons from the microalga Botryococcus braunii". Journal of Applied Phycology 6 3 (1994): 289-293. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028095748&partnerID=MN8TOARS. Sebastiao, M.J.; Cabral, J.M.S.; Aires-Barros, M.R.. "Partitioning of recombinant rusarium solani pisi cutinase in polyethylene glycol-aqueous salt solution two-phase systems". Journal of Chromatography A 668 1 (1994): 139-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028360440&partnerID=MN8TOARS. 10.1016/0021-9673(94)80102-9 Taipa, M.A.; Cabral, J.M.S.; Santos, H.. "Comparison of glucose fermentation by suspended and gel-entrapped yeast cells: An in vivo nuclear magnetic resonance study". Biotechnology and Bioengineering 41 6 (1993): 647-653. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027572086&partnerID=MN8TOARS. Pires, M.J.; Prazeres, D.M.F.; Cabral, J.M.S.. "Protein assay in reversed micelle solutions". Biotechnology Techniques 7 4 (1993): 293-294. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000147642&partnerID=MN8TOARS. 10.1007/BF00150901 Pires, M.J.; Cabral, J.M.S.. "Liquid-liquid extraction of a recombinant protein with a reverse micelle phase". Biotechnology Progress 9 6 (1993): 647-650. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027688138&partnerID=MN8TOARS. Sebastiao, M.J.; Cabral, J.M.S.; Aires-Barros, M.R.. "Synthesis of fatty acid esters by a recombinant cutinase in reversed micelles". Biotechnology and Bioengineering 42 3 (1993): 326-332. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027627398&partnerID=MN8TOARS. Prazeres, D.M.F.; Garcia, F.A.P.; Cabral, J.M.S.. "An ultrafiltration membrane bioreactor for the lipolysis of olive oil in reversed micellar media". Biotechnology and Bioengineering 41 8 (1993): 761-770. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027909203&partnerID=MN8TOARS. Prazeres, D.M.F.; Lemos, F.; Garcia, F.A.P.; Cabral, J.M.S.. "Modeling lipolysis in a reversed micellar system: Part II - Membrane reactor". Biotechnology and Bioengineering 42 6 (1993): 765-771. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027909876&partnerID=MN8TOARS. Sebastião, M.J.; Cabral, J.M.S.; Aires-Barros, M.R.. "Fusarium solani pisi recombinant cutinase partitioning in peg/potassium phosphate aqueous two-phase systems". Biotechnology Techniques 7 9 (1993): 631-634. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000982658&partnerID=MN8TOARS. 10.1007/BF00151860 Fonseca, L.P.; Cardoso, J.P.; Cabral, J.M.S.. "Immobilization studies of an industrial penicillin acylase preparation on a silica carrier". Journal of Chemical Technology and Biotechnology 58 1 (1993): 27-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027219107&partnerID=MN8TOARS. Prazeres, D.M.F.; Lemos, F.; Garcia, F.A.P.; Cabral, J.M.S.. "Modeling lipolysis in a reversed micellar system: Part I. Conventional batch reactor". Biotechnology and Bioengineering 42 6 (1993): 759-764. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027337621&partnerID=MN8TOARS. Prazeres, D.M.F.; Garcia, F.A.P.; Cabral, J.M.S.. "Colorimetric assays for the determination of dioctyl sodium sulphosuccinate and glycerol in reversed micelles". Biotechnology Techniques 7 1 (1993): 1-4. http://www.scopus.com/inward/record.url?eid=2-s2.0-0542439623&partnerID=MN8TOARS. 10.1007/BF00151080 Oliveira, A.C.; Cabral, J.M.S.. "Kinetic studies of Mucor miehei lipase in phosphatidylcholine microemulsions". Journal of Chemical Technology and Biotechnology 56 3 (1993): 247-252. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027471718&partnerID=MN8TOARS. Pinheiro, H.M.; Cabral, J.M.S.. "Screening of whole-cell immobilization procedures for the ¿1-dehydrogenation of steroids in organic medium". Enzyme and Microbial Technology 14 8 (1992): 619-624. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026908640&partnerID=MN8TOARS. 10.1016/0141-0229(92)90036-N Vidal, M.I.; Serralheiro, M.L.M.; Cabral, J.M.S.; Serralheiro, M.L.; Empis, J.M.. "Thermostability of a-chymotrypsin in water/organic solvent systems". Biotechnology Letters 14 11 (1992): 1041-1044. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026495877&partnerID=MN8TOARS. 10.1007/BF01021055 Taipa, M.A.; Aires-Barros, M.R.; Cabral, J.M.S.. "Purification of lipases". Journal of Biotechnology 26 2-3 (1992): 111-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026677176&partnerID=MN8TOARS. 10.1016/0168-1656(92)90001-P Calvet, S.; Clapes, P.; Vigo, J.P.; Xaus, N.; Jorba, X.; Mas, R.M.; Torres, J.L.; et al. "Application of empirical design methodologies to the study of the influence of reaction conditions and N-a-protecting group structure on the enzymatic X-Phe-Leu-NH2 dipeptide synthesis in buffer/dimethylformamide solvent systems". Biotechnology and Bioengineering 39 5 (1992): 539-549. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027112169&partnerID=MN8TOARS. Pinheiro, H.M.; Cabral, J.M.S.. "Activity and stability of an entrapped-cell system for the ¿1-dehydrogenation of steroids in organic media". Biotechnology and Bioengineering 40 9 (1992): 1123-1127. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026955782&partnerID=MN8TOARS. 10.1002/bit.260400918 Taipa, M.A.; Aires-Barros, M.R.; Cabral, J.M.S.. "Purification of lipases from Chromobacterium viscosum: Is there a high molecular weight lipase?". Biotechnology Techniques 6 6 (1992): 533-538. http://www.scopus.com/inward/record.url?eid=2-s2.0-51249162969&partnerID=MN8TOARS. 10.1007/BF02447827 Santos, J.A.L.; Cabral, J.M.S.; Cooney, C.L.. "Recovery of alkaline proteases by membrane filtration. Effect of membrane type and addition of submicron sized charged particles". Bioprocess Engineering 7 5 (1992): 205-211. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026531279&partnerID=MN8TOARS. Prazeres, D.M.F.; Garcia, F.A.P.; Cabral, J.M.S.. "Kinetics and stability of a Chromobacterium viscosum lipase in reversed micellar and aqueous media". Journal of Chemical Technology and Biotechnology 53 2 (1992): 159-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026507204&partnerID=MN8TOARS. Marques, P.A.S.S.; Palavra, A.M.F.; Cabral, J.M.S.. "Effect of pressure on the extractive biocatalysis of ethanol". Journal of Chemical Technology and Biotechnology 55 1 (1992): 25-31. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026759314&partnerID=MN8TOARS. Fevereiro, P.; Pais, M.S.S.; Cabral, J.M.S.. "Production of silybin-like compounds in cell suspension cultures of Silybum marianum". Planta Medica 57 SUPPL. 2 (1991): http://www.scopus.com/inward/record.url?eid=2-s2.0-0026344848&partnerID=MN8TOARS. Mateus, M.; Cabral, J.M.S.. "Steroid recovery by a rotary membrane system". Biotechnology Techniques 5 1 (1991): 43-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-0006371903&partnerID=MN8TOARS. 10.1007/BF00152754 Oliveira, A.C.; Cabral, J.M.S.. "Production and extractive biocatalysis of ethanol using microencapsulated yeast cells and lipase system". Journal of Chemical Technology and Biotechnology 52 2 (1991): 219-225. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025880374&partnerID=MN8TOARS. Aires-Barros, M.R.; Cabral, J.M.S.. "Selective separation and purification of two lipases from Chromobacterium viscosum using AOT reversed micelles". Biotechnology and Bioengineering 38 11 (1991): 1302-1307. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026333653&partnerID=MN8TOARS. Pinheiro, H.M.; Cabral, J.M.S.. "Effects of solvent molecular toxicity and microenvironment composition on the ¿1 dehydrogenation activity of Arthrobacter simplex cells". Biotechnology and Bioengineering 37 2 (1991): 97-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025980899&partnerID=MN8TOARS. Cabral, J.M.; Kennedy, J.F.. "Covalent and coordination immobilization of proteins.". Bioprocess technology 14 (1991): 73-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025984105&partnerID=MN8TOARS. Santos, R.A.; Caldeira, J.C.G.; Pinheiro, H.M.; Cabral, J.M.S.. "Steroid bioconversion in a novel aqueous two-phase system". Biotechnology Letters 13 5 (1991): 349-354. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025905821&partnerID=MN8TOARS. Barreto, M.C.; Cabral, J.M.S.. "Immobilization of Desulfovibrio vulgaris cells with hydrogenase activity". Journal of Chemical Technology and Biotechnology 50 4 (1991): 563-570. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026030389&partnerID=MN8TOARS. Cabral, J.M.. "Extractive removal of product by biocatalysis.". Bioprocess technology 11 (1991): 207-235. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025928281&partnerID=MN8TOARS. Smolders, A.J.J.; Pinheiro, H.M.; Noronha, P.; Cabral, J.M.S.. "Steroid bioconversion in a microemulsion system". Biotechnology and Bioengineering 38 10 (1991): 1210-1217. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026417570&partnerID=MN8TOARS. 10.1002/bit.260381013 Silva, A.B.; Arrabaca, M.C.; Cabral, J.M.S.. "Extraction of crassulacean acid metabolism-phosphoenolpyruvate carboxylase using aqueous two phase systems". Plant Science 76 1 (1991): 29-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-44949280725&partnerID=MN8TOARS. Kennedy, J.F.; Cabral, J.M.S.. "Use of titanium species for the immobilization of cells". Transition Metal Chemistry 15 3 (1990): 197-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-0011955625&partnerID=MN8TOARS. 10.1007/BF01038375 Serralheiro, M.L.; Empis, J.M.; Cabral, J.M.S.. "Peptide synthesis by microencapsulated chymotrypsin". Annals of the New York Academy of Sciences 613 (1990): 638-642. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025652797&partnerID=MN8TOARS. Vicente, M.L.C.; Aires-Barros, M.R.; Cabral, J.M.S.. "Purification of Chromobacterium viscosum lipases using reversed micelles". Biotechnology Techniques 4 2 (1990): 137-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000804329&partnerID=MN8TOARS. 10.1007/BF00163288 Castro, M.J.M.; Cabral, J.M.S.. "Stability of hydrogenase in AOT reversed micelles". Enzyme and Microbial Technology 11 10 (1989): 668-672. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024748724&partnerID=MN8TOARS. Aires-Barros, M.R.; Cabral, J.M.S.; Willson, R.C.; Hamel, J.-F.P.; Cooney, C.L.. "Esterification-coupled extraction of organic acids: partition enhancement and underlying reaction and distribution equilibria". Biotechnology and Bioengineering 34 7 (1989): 909-915. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024962536&partnerID=MN8TOARS. Passarinho, Paula C.L.V.; Vieira, Ana M.S.; Cabral, Joaquim M.S.; Novais, Julio M.; Kennedy, John F.. "Effect of carrier matrix on fermentative production of ethanol by surface immobilised yeast cells". Journal of Chemical Technology and Biotechnology 44 3 (1989): 183-194. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024905144&partnerID=MN8TOARS. Anselmo, A.M.; Cabral, J.M.S.; Novais, J.M.. "The adsorption of Fusarium flocciferum spores on celite particles and their use in the degradation of phenol". Applied Microbiology and Biotechnology 31 2 (1989): 200-203. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000688665&partnerID=MN8TOARS. 10.1007/BF00262463 Vieira, A.M.; Sá-Correia, I.; Novais, J.M.; Cabral, J.M.S.. "Could the improvements in the alcoholic fermentation of high glucose concentrations by yeast immobilization be explained by media supplementation?". Biotechnology Letters 11 2 (1989): 137-140. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042612476&partnerID=MN8TOARS. 10.1007/BF01192190 Mateus, M.; Cabral, J.M.S.. "Recovery of 6-a-methylprednisolone from biotransformation medium by tangential flow filtration". Bioprocess Engineering 4 4 (1989): 169-174. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024493513&partnerID=MN8TOARS. 10.1007/BF00369396 Castro, M.J.M.; Cabral, J.M.S.. "Kinetic studies of hydrogenase in AOT reversed micelles". Enzyme and Microbial Technology 11 1 (1989): 6-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024542987&partnerID=MN8TOARS. 10.1016/0141-0229(89)90105-1 Castro, M.J.M.; Cabral, J.M.S.. "Reversed micelles in biotechnological processes". Biotechnology Advances 6 2 (1988): 151-167. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024144461&partnerID=MN8TOARS. Kennedy, J.F.; Cabral, J.M.S.. "Use of modified titanium etc. species for the immobilization of bioactive compounds-enzymes". Transition Metal Chemistry 12 6 (1987): 481-493. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342394701&partnerID=MN8TOARS. 10.1007/BF01023831 Cabral, J.M.S.; Kennedy, J.F.. "[31] Immobilization of microbial cells on transition metal-activated supports". Methods in Enzymology 135 C (1987): 357-372. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023080178&partnerID=MN8TOARS. 10.1016/0076-6879(87)35092-X Aires Barros, M.R.; Cabral, J.M.S.; Novais, J.M.. "Production of ethanol by immobilized Saccharomyces bayanus in an extractive fermentation system". Biotechnology and Bioengineering 29 9 (1987): 1097-1104. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023365739&partnerID=MN8TOARS. Kennedy, J.F.; Cabral, J.M.S.. "[8] Immobilization of enzymes on transition metal-activated support". Methods in Enzymology 135 C (1987): 117-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023070989&partnerID=MN8TOARS. 10.1016/0076-6879(87)35069-4 Figueiredo, A.C.; Fevereiro, P.; Cabral, J.M.S.; Novais, J.M.; Salomé, M.; Pais, S.. "Callus and suspension cultures for biomass production of Cynara cardunculus (Compositae)". Biotechnology Letters 9 3 (1987): 213-218. http://www.scopus.com/inward/record.url?eid=2-s2.0-0343034603&partnerID=MN8TOARS. 10.1007/BF01024569 Klier, J.; Cabral, J.M.S.; Cooney, C.L.. "Oxygen limitation on L-serine production in a hollow-fiber bioreactor". Applied Biochemistry and Biotechnology 13 3 (1986): 181-187. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023020265&partnerID=MN8TOARS. 10.1007/BF02798456 Kennedy, J.F.; Cabral, J.M.S.. "Use of titanium etc. Species for the immobilization of bioactive compounds - Enzymes". Transition Metal Chemistry 11 2 (1986): 41-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022668198&partnerID=MN8TOARS. 10.1007/BF00618603 Cabral, J.M.S.; Novais, J.M.; Kennedy, J.F.. "Immobilization studies of whole microbial cells on transition metal activated inorganic supports". Applied Microbiology and Biotechnology 23 3-4 (1986): 157-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022617137&partnerID=MN8TOARS. Fevereiro, P.; Cabral, J.M.S.; Fonseca, M.M.R.; Novais, J.M.; Pais, M.S.S.. "Callus and suspension culture of Silybum marianum. Biosynthesis of proteins with clotting activity". Biotechnology Letters 8 1 (1986): 19-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-0005668805&partnerID=MN8TOARS. 10.1007/BF01044394 Cabral, J.M.S.; Novais, J.M.; Cardoso, J.P.; Kennedy, J.F.. "DESIGN OF IMMOBILISED GLUCOAMYLASE REACTORS USING A SIMPLE KINETIC MODEL FOR THE HYDROLYSIS OF STARCH.". Journal of Chemical Technology and Biotechnology 36 6 (1986): 247-254. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022732557&partnerID=MN8TOARS. Rosa, M.F.; Vieira, A.M.; Bartolomeu, M.L.; Sa Correia, I.; Cabral, J.M.S.; Novais, J.M.. "Production of high concentration of ethanol from mash, juice and pulp of Jerusalem artichoke tubers by Kluyveromyces fragilis". Enzyme and Microbial Technology 8 11 (1986): 673-676. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022806573&partnerID=MN8TOARS. Anselmo, A.M.; Mateus, M.; Cabral, J.M.S.; Novais, J.M.. "Degradation of phenol by immobilized cells of Fusarium flocciferum". Biotechnology Letters 7 12 (1985): 889-894. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022400069&partnerID=MN8TOARS. Cabral, J.M.S.; Gasale, B.; Cooney, C.L.. "Effect of antifoam agents and efficiency of cleaning procedures on the cross-flow filtration of microbial suspensions". Biotechnology Letters 7 10 (1985): 749-752. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022378375&partnerID=MN8TOARS. Kennedy, J.F.; Cabral, J.M.S.; Kalogerakis, B.. "Comparison of action patterns of gelatin-entrapped and surface-bound glucoamylase on an a-amylase degraded starch substrate: A critical examination of reversion products". Enzyme and Microbial Technology 7 1 (1985): 22-28. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021874647&partnerID=MN8TOARS. 10.1016/0141-0229(85)90005-5 Cabral, J.M.S.; Cardoso, J.P.; Novais, J.M.; Kennedy, J.F.. "A simple kinetic model for the hydrolysis of a-d-glucans using glucoamylase immobilized on titanium (IV) activated porous silica". Enzyme and Microbial Technology 6 8 (1984): 365-370. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021479449&partnerID=MN8TOARS. Cabral, J.M.S.; Cadete, M.M.; Novais, J.M.; Cardoso, J.P.. "Immobilization of yeast cells on transition metal-activated pumice stone". Annals of the New York Academy of Sciences VOL. 434 (1984): 483-486. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021732083&partnerID=MN8TOARS. Kennedy, J.F.; Kalogerakis, B.; Cabral, J.M.S.. "Immobilization of enzymes on crosslinked gelatin particles activated with various forms and complexes of titanium(IV) species". Enzyme and Microbial Technology 6 2 (1984): 68-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021373034&partnerID=MN8TOARS. Cabral, J.M.S.; Novais, J.M.; Cardoso, J.P.. "COUPLING OF GLUCOAMYLASE ON ALKYLAMINE DERIVATIVE OF TITANIUM (IV) ACTIVATED CONTROLLED PORE GLASS WITH TANNIC ACID.". Biotechnology and Bioengineering 26 4 (1984): 386-388. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021408779&partnerID=MN8TOARS. Cabral, J.M.S.; Novais, J.M.. "ETHANOL PRODUCTION KINETICS AND OPERATIONAL STABILITY OF IMMOBILIZED SACCHAROMYCES CEREVISIAE CELLS.". (1984): 381-387. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021662192&partnerID=MN8TOARS. Cabral, J.M.S.; Kennedy, J.F.; Novais, J.M.; Cardoso, J.P.. "Compositions and compositional-behavioural relationships of enzymes immobilized on porous inorganic supports via titanium(IV) species". Enzyme and Microbial Technology 6 5 (1984): 228-232. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021429971&partnerID=MN8TOARS. Cabral, J.M.S.; Fevereiro, P.; Novais, J.M.; Pais, M.S.S.. "COMPARISON OF IMMOBILIZATION METHODS FOR PLANTS CELLS AND PROTOPLASTS.". Enzyme Engineering: Proceedings of the International Enzyme Engineering Conference (1984): 501-503. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021546151&partnerID=MN8TOARS. Kennedy, J.F.; Kalogerakis, B.; Cabral, J.M.S.. "Surface immobilization and entrapping of enzymes on glutaraldehyde crosslinked gelatin particles". Enzyme and Microbial Technology 6 3 (1984): 127-131. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021388586&partnerID=MN8TOARS. Cabral, J.M.S.; Novais, J.M.; Kennedy, J.F.; Cardoso, J.P.. "Immobilization of biocatalysts on new route transition metal-activated inorganic supports". Enzyme and Microbial Technology 5 1 (1983): 30-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020587530&partnerID=MN8TOARS. Cabral, J.M.S.; Novais, J.M.; Cardoso, J.P.. "Production of high glucose syrups using glucoamylase immobilized on alkylamine derivatives of titanium(IV)-activated porous silica: Kinetics and operat". The Chemical Engineering Journal 27 3 (1983): http://www.scopus.com/inward/record.url?eid=2-s2.0-0020894462&partnerID=MN8TOARS. Cabral, J.M.S.; Novais, J.M.; Cardaso, J.P.. "MODELING OF IMMOBILIZED GLUCOAMYLASE REACTORS.". Annals of the New York Academy of Sciences 413 (1983): 535-541. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020892216&partnerID=MN8TOARS. Cabral, J.M.S.; Kennedy, J.F.; Novais, J.M.. "Investigation of the binding mechanism of glucoamylase to alkylamine derivatives of titanium(IV)-activated porous inorganic supports". Enzyme and Microbial Technology 4 5 (1982): 337-342. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020180318&partnerID=MN8TOARS. Cabral, J.M.S.; Kennedy, J.F.; Novais, J.M.. "Investigation of the operational stabilities and kinetics of glucoamylase immobilized on alkylamine derivatives of titanium(IV)-activated porous inorganic supports". Enzyme and Microbial Technology 4 5 (1982): 343-348. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020180317&partnerID=MN8TOARS. Dias, S.M.M.; Novais, J.M.; Cabral, J.M.S.. "Immobilization of yeasts on titanium activated inorganic supports". Biotechnology Letters 4 3 (1982): 203-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020064123&partnerID=MN8TOARS. Cabral, J.M.S.; Cardoso, J.P.; Novais, J.M.. "Influence of coupling conditions on activity and operational stability of glucoamylase immobilized on titanium (IV)-activated controlled pore glass". Enzyme and Microbial Technology 3 1 (1981): 41-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-0019380423&partnerID=MN8TOARS.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/02/23	Bioprocess Engineering for Cell Therapies and Regenerative Medicine	Academia de Ciências de Lisboa (Lisboa, Portugal)
2022/03/11	Bioengineering Challenges for Stem Cell-based Therapies and Regenerative Medicine	12th International Meeting of the ¿Portuguese Society for ...Stem Cells and Cell Therapies Portuguese Society for ...Stem Cells and Cell Therapies (Braga, Portugal)
2020/09/18	Bioengineering Strategies for Stem Cell-based Therapies and Regenerative Medicine	International Conference on Tissue Engineering and Regenerative Medicine International Conference on Tissue Engineering and Regenerative Medicine (Paris, France)
2020/02	Enhancing synthetic scaffolds biological performance and osteoinductive properties using stem cell-derived extracellular matrix	Polymer Science and Composite Materials Conference Polymer Connect (Lisbon, Portugal)
2020/02	The Dual Role of Electricity on Scaffolds: Preparation and Applications	Polymer Science and Composite Materials Conference Polymer Connect - (Lisbon, Portugal)
2019/12	Engineering of Human Forebrain Organoids from Human Induced Pluripotent Stem Cells for Modeling of Rett Syndrome	7th International Conference on Stem Cell Engineering AIChE (Barcelona, Spain)
2019/05	Promoting Angiogenesis Phenomena using Magnetic Scaffolds	BIOMATSEN BIOMATSEN (Oludeniz , Turkey)
2019/05	Magnetic Scaffolds To Promote Angiogenesis	TERMIS EU2019 TERMIS (Rhodes, Greece)
2018/12	Transcriptomic analysis of 3D Cardiac Differentiation of Human Induced Pluripotent Stem Cells Reveals Faster Maturation Compared to 2D Culture	6th International Conference on Stem Cell Engineering AIChE (Los Angeles, United States)
2018/12	Development and Characterization of Brain Region-Specific Organoids from Human Induced Pluripotent Stem Cells for Modelling of Rett Syndrome	6th International Conference on Stem Cell Engineering AIChE (Los Angeles, United States)
2018/09	A Bioeconomics model for bioprocessing of Pluripotent stem cells	12th Symposium of the European Society of Biochemical Engineering Sciences, ESBES 2018 European Society of Biochemical Engineering Sciences (Lisbon, Portugal)
2017/01	Xeno-free Production and Recovery of Human Induced Pluripotent Stem Cells using Synthetic Dissolvable Microcarriers	Scale-up and Manufacturing of Cell-based Therapies V Engineering Conferences International (San Diego, United States)
2016/12	Scaling-up a Chemically-Defined Aggregate-Based Suspension Culture System for Neural Commitment of Human Induced Pluripotent Stem Cells	5th International Conference on Stem Cell Engineering AIChE (Toronto, Canada)
2016/09	Upscaling Neural Commitment of Human Pluripotent Stem Cells using Dual SMAD Inhibition in Suspension Conditions	European Symposium on Biochemical Engineering Sciences (ESBES) 2016 European Symposium on Biochemical Engineering Sciences (Dublin, Ireland)
2016/09	Xeno-free Expansion of Human Induced Pluripotent Stem Cells in Scalable Stirred Microcarrier Culture Systems	European Symposium on Biochemical Engineering Sciences (ESBES) 2016 European Symposium on Biochemical Engineering Sciences (Dublin, Ireland)
2016/06/27	Bioprocess Engineering Strategies for Stem Cell-based Therapies and Regenerative Medicine	Invited Lecture at the “Distinguished Chemical Engineering Seminar Series”, Imperial College London, June 2016 Imperial College London (London, United Kingdom)
2016/03	Bioengineering strategies for Stem Cell-based Therapies and Regenerative Medicine	20th Annual Regenerative Medicine Workshop Georgia Institute of Technology (Hilton Head, South Carolina, United States)
2016/03	Factorial Analysis Of Signaling Pathways Involved In Pluripotency And Lineage Specification Reveals A Dominant Effect Of Wnt Signaling In Mesendoderm Differentiation Of Human Pluripotent Stem Cells	20th Annual Regenerative Medicine Workshop Georgia Institute of Technology (Hilton Head, South Carolina, United States)
2015/02	Human Megakaryopoiesis Ex-Vivo: Cell Population Modelling Approach	Sixth Workshop Dynamical Systems Applied to Biology and Natural Sciences DSABNS 2015 Dynamical Systems Applied to Biology and Natural Sciences (Lisbon, Portugal)
2015/01	Scalable production of human mesenchymal stem/stromal cells in microcarrier-based stirred culture systems	Scale-Up and Manufacturing of Cell-Based Therapies IV ECI (San Diego, United States)
2015/01	Temporal and spatial control of the neural commitment of human pluripotent stem cells as suspension aggregates	Scale-up and Manufacturing of Cell-Based Therapies III ECI
2014/09	Bioengineering strategies for ex-vivo cultivation and purification of stem cells	CHEMPOR 2014 Universidade do Porto (Porto, Portugal)
2014/09	Bioengineering Strategies for Stem Cell-based Therapies and Regenerative Medicine	10th European Symposium on Biochemical Engineering Science Université de Lille (Lille)
2014/09	Integrated Platform for Derivation and Enrichment of Human Pluripotent Stem Cell-Derived Cardiomyocytes: Towards Clinical Applications	10th European Symposium on Biochemical Engineering Sciences and 6th International Forum on Industrial Bioprocesses European Symposium on Biochemical Engineering Science (Lille, France)
2014/06	Electrospun nanofiber based scaffold platform for neural stem cell alignment	Termis EU 2014 TERMIS (Bologna, Italy)
2014/05	Nonviral Gene Delivery to Neural Stem Cells with Minicircles by Microporation	3rd Minicircle & DNA Vector Conference (Biefeld, Germany)
2014/03	Purification of Human Induced Pluripotent Stem Cell-Derived Neural Progenitors for Regenerative Medicine Applications	4th International Conference on Stem Cell Engineering AIChE (San Diego, United States)
2014/01	Scalable expansion of human induced pluripotent stem cells in xeno-free microcarriers	Scale-up and Manufacturing of Cell-Based Therapies III ECI (San Diego, United States)
2013/11	Bioengineering strategies for ex-vivo cultivation and purification of human stem cells,	Oxford Global Stem Cell Congress, London, November 2013 Oxford Global (London, United Kingdom)
2013/08	Gene Delivery Strategies to Efficiently Over-express HLA-G in Bone Marrow-Derived Mesenchymal Stromal Cells	”, MSC 2013 (Cleveland, United States)
2013/07	Bioengineering strategies for human stem cells processing	NSF Workshop New Directions for Tissue Engineering and Regenerative Medicine, Sonoma, California, July 2013 National Science Foundation (Sonoma, California, United States)
2013/04	Purification of Human Induced Pluripotent Stem Cell-Derived Neural Progenitors for Regenerative Medicine Applications	9th European Congress of Chemical Engineering/2nd European Congress of Applied Biotechnology ESBES (The Hague, Netherlands)
2013/04	A multi-phase protocol for the expansion and megakaryocytic differentiation of umbilical cord blood hematopoietic stem/progenitor cells	9th European Congress of Chemical Engineering & 2nd European Congress of Applied Biotechnology ESBES (The Hague, Netherlands)
2012/10	Isolation and Characterization of Mesenchymal Stem Cells From Umbilical Cord Matrix Using a Fully Defined Serum-/Xeno-free System	Annual Meeting of the Biomedical Engineering Society (BMES) Biomedical Engineering Society (BMES) (Atlanta, United States)
2012/09	Bioengineering approaches for the optimization of the ex-vivo expansion of hematopoietic stem/progenitor cell for cell therapy	9th European Symposium on Biochemical Engineering Science (ESBES) ESBES (Istanbul, Turkey)
2012/09	Scalable expansion of human mesenchymal stem cells using a microcarrier-based system under serum-free and xeno-free conditions	9th European Symposium on Biochemical Engineering Science (ESBES) ESBES (Istanbul, Turkey)
2012/09	Three-dimensional neural stem cell culture microarray for high-throughput studies of neuronal differentiation and toxicology	9th European Symposium on Biochemical Engineering Science (ESBES) ESBES (Istanbul, Turkey)
2012/09	Design and operation of a bioreactor system for the expansion of mouse embryonic stem cell-derived neural stem cells on microcarriers	9th European Symposium on Biochemical Engineering Science ESES (Istanbul, Turkey)
2012/09	An appraisal of human mtDNA instability: role of DNA topology and sequence motifs	15th European Congress on Biotechnology-Biocrossroads EFB (Istanbbul)
2012/04	Bioengineering approaches for the optimizationof the ex-vivo expansion of hematopoietic stem/progenitor cell for cell therapy	3rd International Conference on Stem Cell Engineering AIChE (Seatle, United States)
2012/03	Towards optimal culture conditions for the exvivo expansion of umbilical cord blood hematopoietic stem/progenitor cells for cell therapy	243rd ACS National Meeting – Chemistry of Life ACS (San Diego, United States)
2012/03	Multifactorial analysis of embryonic stem cell selfrenewal reveals a crucial role of GSK-3-mediated signaling at physiological oxygen levels	243rd ACS National Meeting – Chemistry of Life ACS (San Diego, United States)
2012/03	Scalable expansion of human mesenchymal stem cells using a microcarrier- based system under serum-free and xeno-free conditions	243rd ACS National Meeting – Chemistry of Life ACS (San Diego, United States)
2012/03	Design And Operation Of A Bioreactor System For The Expansion Of Mouse Embryonic Stem Cell-Derived Neural Stem Cells On Microcarriers	243rd ACS National Meeting – Chemistry of Life ACS (San Diego, United States)
2012/01	Scalable expansion of human mesenchymal stem cells using a microcarrier-based system under serum-free and xeno-free conditions	Scale-Up and Manufacturing of Cell-Based Therapies ECI (San Diego, United States)
2010/11	Stem cells: High-throughput cellular microarray platforms and applications in drug discovery	2nd National Meeting on Medicinal Chemistry (Coimbbra, Portugal)
2010/10	Utilização clínica de células estaminais	IX Congresso Luso-Brasileiro de Transplantação (Porto, Portugal)
2010/10	Monitoring stem cell cultivations with NIR spectroscopy	The Federation of Analytical Chemistry and Spectroscopy Societies Conference The Federation of Analytical Chemistry and Spectroscopy Societies (Raleigh, North Carolina, United States)
2010/09	Bioengineering strategies for stem cell expansion and controlled differentiation 8th European Symposium on	Biochemical Engineering Science \| ESBES, Bologna, Italy, September [Plenary Lecture] 2010 University of Bologna (Bologna, Italy)
2010/09	Steroid biotransformation and in situ separation within microchannel system	International thematic conference Implementation of microreactor technology into biotechnology \| IMTB (Ljubjana, Slovenia)
2010/09	Scale-up of mouse embryonic stem cell expansion: from spinner-flask to a fully controlled bioreactor	8th European Symposium on Biochemical Engineering Science \| ESBES ESBES (Bologna, Italy)
2010/09	Synthetic application and activity of cutinase in miniemulsion model system: hexyl octanoate synthesis	9th Congress on Catalysis Applied to Fine Chemicals \| CAFC9 Congress on Catalysis Applied to Fine Chemicals (Zaragoza, Spain)
2010/07	Ex-vivo expansion of human stem cells for cellular therapy,	OCT 2nd International Workshop - Focus on Advanced Arterial Imaging and Stem Cell Therapy, OCT 2nd International Workshop (Lisboa, Portugal)
2010/06	The use of microchannel reactors for steroid biotransformation: in-situ product formation and recovery	Achemasia Achema (Beijing, China)
2010/05	Effect of hypoxia on proliferation and neural commitment of embryonic stem cells at different stages of pluripotency	2nd International Conference on Stem Cell Engineering ECI (Boston, United States)
2009/07	The sunny side of Mycobacteria	European Society of Mycobacteriology (Porto, Portugal)
2009/05	Steroids bioconversion: towards green processes	29th International Exhibition- Congress on Chemical Engineering, Environmental Protection and Biotechnology \| ACHEMA 2009 ACHEMA (Frankfurt, Germany)
2009/05	Carbohydrate hydrolysis with com- mercial inulinase entrapped in PVA-based beads	29th International Exhibition-Congress on Chemical Engineering, Environmental Protection and Biotechnology \| ACHEMA 2009 ACHEMA (Frankfurt, Germany)
2009/01	A dual purpose immobilized biocatalyst for inulin and sucrose hydrolysis	Carbohydrates as Organic Raw Materials V (CORM V) (Lisbon, Portugal)
2008/09	Exploring stem cell fate using three-dimensional cellular microarrays	7th European Symposium on Biochemical Engineering Science –ESBES 7 ESBBES (Faro, Portugal)
2008/09	A highthroughput 3D cell microarray to study stem cell fate	7th European Symposium on Biochemical Engineering – ESBES 7 ESBES (Faro, Portugal)
2008/09	Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system	10th International Chemical and Biological Engineering Conference – CHEMPOR 2008 CHEMPOR (Braga, Portugal)
2008/09	Nano and micro-biocatalysts manufacture and their impact on the synthesis of ß-lactamic antibiotics	10th International Chemical and Biological Engineering Conference – CHEMPOR 2008 CHEMPOR (Braga, Portugal)
2008/09	Enzymatic synthesis of fatty acid alkyl esters in miniemulsion	7th European Symposium on Biochemical Engineering – ESBES 7 (Faro, Portugal)
2008/09	Studies on fed-batch operation mode on biosynthesis of short chain ethyl esters catalyzed by cutinase	10th International Chemical and Biological Engineering Conference - CHEMPOR 2008 CHEMPOR (Braga, Portugal)
2008/06	Ion jelly®: A tailor-made conducting material for smart electrochemical devices	7th International Symposium on Polyelectrolytes - Polyelectrolytes 2008 (Coimbra, Portugal)
2008/06	Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system	Tissue Engineering and Regenerative Medicine International Society - 2008 Annual Conference TERMIS (Porto, Portugal)
2008/01	Maximization of the ex-vivo expansion of human hematopoietic stem/progenitor cells by direct contact culture with mesenchymal stem cells	First International Conference on Stem Cell Engineering AIChE (San Diego, United States)
2008	Highthroughput 3D cell microarray to study stem cell fate	First International Conference on Stem Cell Engineering AIChE (San Diego, United States)
2006/09	Optimization and Integration of the Expansion and Neural Commitment of Mouse Embryonic Stem Cells	6th European Symposium on Biochemical Engineering Science ESBES (SAlzbburg, Austria)
2006/05	Ex-vivo Expansion of Human Hematopoietic Stem Cells in Stromal-based Culture Systems	3rd International Meeting: Stem Cell Network North Rhine Westphalia Stem Cell Network North Rhine Westphalia (Muenster, Germany)
2001/09	Study of Reaction Parameters for an Alcoholysis Transformation Promoted by a Cutinase Immobilized on Polyamide PA6 and NaY Zeolite throughFactorial Design Methodology	5th European Congress on Catalysis EuropaCat V EuropaCat (Limerick, Ireland)
2001/07	Cutinase Engineering: from Molecular Level to Bioprocess Development in Organic Media	10th European Congress on Biotechnology EFBB (Madrid, Spain)
1998/09	Biochemical Engineering Science: Fundamentals and Applications	7th International Chemical Engineering Conference CHEMPOR’98 CHEMPOR (Lisbon, Portugal)
1998/07	Fusarium solani Cutinase in Reversed Micelles: Stabilisation Strategies and Operational Stability	1st International Symposium on Enzyme Stabilisation (Leeds, United Kingdom)
1997/08	Deactivation and Conformational Changes of Cutinase in Reverse Micelles	8th European Congress on Biotechnology EFB (Budapest, Hungary)
1997/05	Cutinase Stability in AOT Reversed Micelles: Process Development for the Synthesis of Short Chain Esters	Enzymes for Food Industry CBB (Rennes, France)
1996/09	Biotransformation in Organic Media by Enzymes and Whole Cells	1st European Symposium on Biochemical Engineering Science ESBES (Dublin, Ireland)
1996/09	Biocatalysis in Organic Media by Cutinase Immobilized in Reversed Micelles and Zeolites	International Conference on Biotechnology for Industrial Production of Fine Chemicals (Zermatt, Switzerland)
1995/05	Process Integration in Enzymatic Synthesis of Dideptides in Organic Solvents	Enzymes for Food CBB (Rennes, France)
1995/05	Design of Immobilized Lipolytic Enzymes for Use in Low Water Media	7th European Congress on Biotechnology EFB (Nice, France)
1994/06	Separation and Purification of Lipases by Liquid-liquid Extraction Processes	NATO Advanced Study Institute on Engineering of/with Lipases NATO Advanced Study Institute (Porto, Portugal)
1994/06	Reversed Membrane Reactors	NATO Advanced Study Institute on Engineering of/with Lipases NATO Advanced Study Institute (Porto, Portugal)
1994/06	Kinetics and Stability of Cutinase Immobilized in Reversed Micelles and Zeolites	NATO Advanced Study Institute on Engineering of/with Lipases NATO Advanced Study Institute (Porto, Portugal)
1994/06	Protein extraction by reversed micellar systems	NATO Advanced Study Institute on Use of Computer and Information Science Applications in Bioprocess Engineering NATO Advanced Study Institute (Porto, Portugal)
1994/06	Modelling of membrane bioreactors	NATO Advanced Study Institute on Use of Computer and Information Science Applications in Bioprocess Engineering NATO Advanced Study Institute (Porto, Portugal)
1993/09	Reversed Micellar Systems in Biocatalysis and Bioseparation of Recombinant Proteins	12nd International Enzyme Engineering Conference ECI (Deauville , France)
1993/02	Olive Oil Hydrolysis/product Separation in a Reversed Micellar Membrane Reactor	Workshop on Integrated Downstream Processing, ESF Programme on "Process Integration in Biochemical Engineering ESF Programme on "Process Integration in Biochemical Engineering (Delft, Netherlands)
1992/08	Liquid-liquid extraction of a recombinant protein with a reversed micellar phase	9th International Biotechnology Symposium (Crystal City, United States)
1992/08	Separação e Imobilização de Enzimas	Seminar Centro de Desenvolvimento Biotecnológico Centro de Desenvolvimento Biotecnológico (Joinville, Brazil)
1992/08	Estratégias de Purificação em Larga Escala de Proteinas Recombinantes	Seminar, Vallée Nordeste, Vallée Nordeste, (Montes Claros, Minas Gerais, Brazil)
1992/08	Extracção biocatalítica de etanol com reacção enzimática	Seminar, Instituto Tecnológico do Estado de Pernambuco Instituto Tecnológico do Estado de Pernambuco (Recife, Pernambbuco, Brazil)
1992/08	Extracção de Proteinas por Sistemas Micelares	Seminar, Departamentos de Bioquímica e de Engenharia Química da Universidade Federal de Pernambuco Universidade Federal de Pernambuco (Recife, Pernambuco, Brazil)
1991/10	Selective Extraction and Purification, Kinetics and Membrane Bioreaction Systems of Microbial Lipases using Reversed Micelles	Conference LIpases Geselschaft fur Biotecnologische Forschung, Braunschweig ( Braunschweig, Germany)
1991/09	Kinetics and Stability of Microbial Lipases in Reversed Micellar Systems	Forum for Applied Biotechnology (Ghent, Belgium)
1991/01	Purification, Kinetic Characterization and Membrane Reactors of Lipases using Reversed Micellar Systems	The Production of Industrial Enzymes, CEC-ASEAN Workshop CEC-ASEAN (Bangkok, Thailand)
1990/09	Purification and Kinetics Studies of Lipases using Reversed Micelles	Lipases: Structure, Mechanism and Genetic Engineering, CEC-GBF Workshop CEC-GBF (Braunschweig, Germany)
1990/07	Pressure Driven Membrane Processes	NATO Advanced Study Institute on Chromatographic and Membrane Processes in Biotechnology NATO Advanced Study Institute (Água de Alto, S. Miguel, Azores, Portugal)
1990/06	Effect of Immobilization Matrix on Cell Metabolism	3rd Spanish Congress on Biotechnology Spanish Society of Biotechnology (Murcia, Spain)
1990/02	Extractive Biocatalysis in Biotechnology	Seminar, Department of Biochemistry, University of Aberdeen Department of Biochemistry, University of Aberdeen (Abberdeen, Scotland, United Kingdom)
1989/04	Recovery of 6-alfa-Methylprednisolone from Biotransformation Medium by Membrane Filtration: Effect of Type of Membrane, Modules and Modes of Operation	Downstream Processing in Biotechnology II (Brugges, Belgium)
1988/05	Enzyme Enhanced Extraction of Fermentation Products	Seminar, Department of Chemical Engineering, Eidgenossische Technische Hochschule, Zurich Eidgenossische Technische Hochschule, Zurich (Zurich, Switzerland)
1988	Recovery of Fermentation Products by Enzyme Catalysis	Seminar, Department of Chemical Engineering, École Polytechnique Féderale, Lausanne École Polytechnique Féderale, Lausanne (Lausanne, Switzerland)
1987/06	Advances in Downstream Processing as Applied to Biocatalytic Processes	4th European Congress on Biotechnology EFBB (Amsterdam, Netherlands)
1987/02	Integration of Enzyme Catalysis in Extractive Fermentation Processes	Seminar, Department of Chemistry and Biochemistry, University of Georgia Department of Chemistry and Biochemistry, University of Georgia (Athens, Georgia, United States)
1986/12	Integration of Enzyme Catalysis in an Extractive Fermentation Process	International Symposium on Biocatalysis in Organic Media (Wageningen, Netherlands)
1986/09	Cross-Flow Filtration for Recovery of Alkaline Proteases	192nd American Chemical Society Annual Meeting American Chemical Society (Anaheim, California, United States)
1985/02	Immobilized Cell Reactors	Seminar, Center for Biochemical Engineering, Duke University Center for Biochemical Engineering, Duke University (Durham, North Carolina, United States)
1985/02	Alkaline Protease Recovery by Membrane Filtration	Seminar, Biochemical Engineering and Microbiology, Massachusetts Institute of Technology Biochemical Engineering and Microbiology, Massachusetts Institute of Technology (Cambridge, Massachusetts, United States)
1984/08	Bioconversion of Glycine into L-Serine using a Temperature Sensitive Mutant of Pseudomonas AM 1	188th Annual Meeting of American Chemical Society American Chemical Society (Philadelphia, Pennsylvania, United Kingdom)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2017/01/01 - 2020/12/31	Engineering characterization of bioreactors for human pluripotent stem cell expansion and cardiac differentiation Supervisor of Diogo do Espírito Santo Nogueira	Bioengenharia (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2014/12/10 - 2018/12/11	“Scalable Platform for the Expansion of Human Mesenchymal/Stromal Cells under Dynamic Conditions” PhD Bioengineering Instituto Superior Técnico December 2018 (to be held on December, 11 2018) Supervisor of Francisco Moreira	Bioengenharia (PhD) Instituto Superior Técnico, Universidade de Lisbbboa, Portugal
2014/10/01 - 2018/10/01	“Engineering T Cells with Chimeric Antigen Receptors as a Therapy for Hematologicl Cancers” PhD Bioengineering Instituto Superior Técnico October 2018 Supervisor of Diogo Gomes da Silva	Bioengenharia (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2013/12/02 - 2017/12/02	“Defined and Scalable Systems for Neural Differentiation of Human Pluripotent Stem Cells” PhD Biotechnology Instituto Superior Técnico December 2017 (co-supervisor) Supervisor of Gonçalo Morais e Castro Rodrigues	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2013/06/01 - 2017/06/01	“Stem Cell and Stem Cell-free Therapeutics against Myocardial Infarction” PhD Bioengineering Instituto Superior Técnico June 2017 (co-supervisor) Co-supervisor of Ivana Kostic	Bioengenharia (PhD) Instituto Superior Técnico, Universidade de Lisbbboa, Portugal
2013/06/01 - 2017/06/01	“Manufacturing of Mesenchymal/Stromal Cells for Cell Therapies and the Role of the Notch Signaling Pathway in the Human Hematopoietic Systems” PhD Bioengineering Instituto Superior Técnico June 2017 Supervisor of António Maria Santa Marta Soure	Bioengenharia (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2012/05/02 - 2016/05/02	“Human pluripotent Stem Cell Signaling and Cardiac Lineage Commitment” PhD Biotechnology Instituto Superior Técnico May 2016 Supervisor	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2012/04/01 - 2016	“Integrated Platform for Expansion and Controlled Neural Differentiation of Human Pluripotent Stem Cells in a Xeno-free chemically-defined Suspension System” PhD Biotechnology Instituto Superior Técnico April 2016 Supervisor of Cláudia Daniela Canelas Miranda	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2011/12/02 - 2015/12/02	"Synovial Mesenchymal Stromal Cells for Cartilage Repair" PhD in Bioengineering December 2015. Supervisor of Aruna Santhagunam	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2011/12/02 - 2015/12/02	"Development of enzyme microreactors and application in biocatalysis" PhD in Biotechnology and Biosciences December 2015. Co-supervisor	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2011/02/01 - 2015/02/01	“Immunomodulatory Activity of Mesenchymal Stromal Cells” PhD Bioengineering Instituto Superior Técnico February 2015 Supervisor	Bioengenharia Instituto Superior Técnico, Universidade de Lisboa, Portugal
2010/06/01 - 2014/06/01	“Impedance Spectroscopy Analysis of Protein-Surface Interaction Using Acoustic and Interdigital Label-Free Sensors” PhD Bioengineering Instituto Superior Técnico June 2014 (co-supervisor) Co-supervisor	Bioengenharia (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2010/01/01 - 2014/01/03	“Skeletal Muscle Differentiation of Human Mesenchymal Stem Cells (MSC) for Therapeutic Applications” PhD Bioengineering Instituto Superior Técnico January 2014 (co-supervisor) Co-supervisor	Bioengenharia (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2009/07/01 - 2013/07/01	“Platforms for tissue reconstruction: compliant biomaterials for local drug delivery and tissue adhesion” PhD Bioengineering Instituto Superior Técnico July 2013 (co-supervisor) Co-supervisor	Bioengenharia (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2009/06/01 - 2013/06/01	“Genome Wide Expression Approaches Applied to Biomedical research: Long-term Adaptation Burjholderia cenocepacia to Cystic Fibroses Patient’s Airways and Extended Ex-vivo Cultivation of Human Mesenchymal Stem Cells” PhD Biotechnology Instituto Superior Técnico June 2013 (co-supervisor) Co-supervisor	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2008/09/01 - 2012/09/01	“Flailer - a myosin Va neurological mutant displays autistic-like behavior and synaptic defects” PhD Bioengineering Instituto Superior Técnico September 2012 (co-supervisor) Co-supervisor of Swarna Deepa Pandian	Bioengenharia (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2008/06/01 - 2012/06/01	“Permanent Antifungal Materials and Coatings: Bioactivity and Cytotoxicity Characterization” PhD Bioengineering Instituto Superior Técnico June 2012 (co-supervisor) Co-supervisor of Cristiana da Silva Oliveira Paulo	Bioengenharia (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2008/03/01 - 2012/03/01	“Ex-vivo Engineered Combinatorial Micro-Environments for Stem Cell Fate Studies – The Balalnce Between Stem Cell Self-Renewal and Differentiation” PhD Bioengineering Instituto Superior Técnico March 2012 (co-supervisor) Co-supervisor of David Braga Malta	Bioengenharia (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2007/12/02 - 2011/12/02	“Emergence of Tissue Engineering and Disruption of Product Development in Healthcare” PhD Bioengineering Instituto Superior Técnico December 2011 (co-supervisor) Co-supervisor	Bioengenharia (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2007/12/02 - 2011/12/02	“Bioreactor Culture Systems for the Expansion and Neural Commitment of Mouse Embryonic Stem Cells” PhD Bioengineering Instituto Superior Técnico December 2011 Supervisor of Ana Fernandes	Bioengenharia Instituto Superior Técnico, Universidade de Lisboa, Portugal
2007/09/01 - 2011/09/01	“Design and Operation of Bioreactor Systems for the Expansion and Controlled Neural Differentiation of Stem Cells” PhD Bioengineering Instituto Superior Técnico September 2011 Supervisor of Carlos André Vitorino Rodrigues	Bioengenharia (Other) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2007/07/01 - 2011/07/01	“Isolation and Ex-Vivo Expansion of Human Mesenchymal Stem Cells for Supplementation during Hematopoietic Stem Cell Transplantation” PhD Biotechnology Instituto Superior Técnico July 2011 Supervisor of Francisco dos Santos	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2007/07/01 - 2011/07/01	“Novel Approaches for the Isolation and Ex-Vivo Expansion of Hematopoietic Stem Cells from Umbilical Cord Blood for Cell Therapy” PhD Bioengineering Instituto Superior Técnico July 2011 Supervisor of Pedro Zacarias Andrade	Bioengenharia (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2007/06/01 - 2011/06/01	“Lab on Chip microsystem for flow cytometric analysis, separation and counting of cells and particles” PhD Physics Instituto Superior Técnico June 2011 (co-supervisor) Co-supervisor of Joana Loureiro	Física (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2006/11/02 - 2010/11/02	“Enzymatic transesterification of triglycerides by cutinase for biodiesel production” PhD Biotechnology Instituto Superior Técnico November 2010 Supervisor of Sara Martins Badenes	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2005/12/02 - 2009/12/02	“Ex vivo Expansion and Differentiation of Mouse Embryonic Stem Cells in Microbioreactors” PhD Biotechnology Instituto Superior Técnico December 2009 Supervisor of Tiago Gonçalves Fernandes	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2004/06/01 - 2008/06/01	“Magnetoresistive biochips: Detection of biomolecular recognitionand on-chip transport of magnetically labeled biomolecules” PhD Physics Instituto Superior Técnico June 2008 (co-supervisor) Co-supervisor of Hugo Ferreira	Física (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2002/12/02 - 2006/12/02	“Ex-vivo Expansion, Differentiation and Plasticity of Bone Marrow-derived Stem Cells in Bioreactors” PhD Biotechnology Instituto Superior Técnico December 2006 Supervisor of Ana Margarida Frias	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2002/11/02 - 2006/11/02	“Directed evolution of lipolytic enzymes for synthetic reactions” PhD Biotechnology Instituto Superior Técnico November 2006 Supervisor of Vânia Brissos	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2002/03/01 - 2006/03/01	“Ex vivo Expansion and Differentiation of Neural Stem Cells in Suspension Bioreactors” PhD Biotechnology Instituto Superior Técnico March 2006 Supervisor of Elsa Abranches	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2002/02/02 - 2006/02/02	“Design and Operation of a Membrane Stromal Cell Reactor for Hematopoietic Stem Cell Culture” PhD Biotechnology Instituto Superior Técnico February 2006 Supervisor of Raquel Gonçalves	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
2002/02/02 - 2006/02/02	“Ex vivo Expansion of Hematopoietic Stem Cells in an Immobilized Fluidized Bed Stromal Cell Reactor” PhD Biotechnology Instituto Superior Técnico, February 2006 Supervisor of Cláudia Lobato da Silva	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
1998/07/01 - 2002/07/01	“Design of bacterial vector systems for the secretion of recombinant proteins” PhD Biotechnology Instituto Superior Técnico, July, 2002 (co-supervisor) Co-supervisor of Filipe Menezes Mergulhão	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
1998/06/01 - 2002/06/01	“Study of the interactions between reverse micellar components and cutinase” PhD Biotechnology Instituto Superior Técnico, June, 2002 Supervisor of Ana Maria Domingues Gonçalves	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
1998/01/02 - 2002/01/02	“Produção e Recuperação de Células de Trichoderma reesei” PhD Biotechnology Universidade da Beira Interior, January, 2002 Supervisor	Bioquímica (PhD) Universidade da Beira Interior, Portugal
1997/07/01 - 2001/07/01	“Contributo para a Caracterização do Sistema de Lipases de Yarrowia lipolytica” PhD Biotechnology Instituto Superior Técnico, July, 2001 Supervisor of Altino Branco Choupina	Biotecnologia e Biociências (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
1996/07/01 - 2000/07/01	“Produção e Purificação da Proteína Recombinada Sm 13 de Schistosoma mansoni Utilizando Sistemas de Duas Fases Aquosas” PhD Biotechnology Instituto Superior Técnico, July, 2000 Supervisor of Adilson Chaves	Biotecnologia e Biociências (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
1996/06/01 - 2000/06/01	“Partição e Purificação de Penicilina Acilase em Sistemas de Duas Fases Aquosas” PhD Chemistry, Universidade do Minho, June, 2000 Supervisor of João Carlos Marcos	Química (PhD) Universidade do Minho, Portugal
1996/01/02 - 2000/01/02	“Development of Plasmid DNA Downstream Processing Strategies Based on Chromatography” PhD Biotechnology, Instituto Superior Técnico, January, 2000 (co-supervisor) Co-supervisor of Guilherme Matos Ferreira	Biotecnologia e Biociências (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
1995/11/02 - 1999/11/02	“Optimization of a Reversed Micellar System with Microencapsulated Cutinase: Stabilization, Kinetics and Operation in Reactors” PhD Biotechnology, Instituto Superior Técnico, November, 1999 (co-supervisor) Co-supervisor of Cristina M. L. Carvalho	Biotecnologia e Biociências (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
1994/07/01 - 1998/07/01	“Recuperação de uma Cutinase Recombinada por Filtração Vorticular“ PhD Biotechnology, Instituto Superior Técnico, July, 1998 Supervisor of Carlos Alberto Alves da Silva	Biotecnologia e Biociências (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
1994/03/01 - 1998/03/01	“Construção de Bioconjugados: Caracterização e avaliação de propriedades” PhD Biotechnology, Instituto Superior Técnico, March, 1998 Supervisor of Maria Barbara A.F. Martins	Biotecnologia e Biociências (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
1993/05/02 - 1997/05/02	“Sistema de Membranas de Fibras Ocas para Biorreacção/Separação de soluções Aquosas de Amónia e Ureia” PhD Chemical Engineering, Instituto Superior Técnico, May, 1997 Supervisor of Qin Yingjie	Engenharia Química (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
1993/05/02 - 1997/05/02	“Purificação e Caracterização da Lipase de Chromobacterium Viscosum: a sua Homologia com a Lipase de Pseudomonas Glumae” PhD Biotechnology, Instituto Superior Técnico, May, 1997 Supervisor of Maria Ângela C. G. Taipa	Biotecnologia e Biociências (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
1993/02/01 - 1997/02/01	Maria Luisa Serralheiro “Estudos de Actividade e Estabilidade da -Quimotripsina em Micelas Invertidas para Síntese de Dipéptidos em Reactores Enzimáticos” PhD Biochemistry, Faculty of Sciences, University of Lisbon, February 1997 Supervisor of Maria Luisa Serralheiro	Bioquímica (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
1992/11/02 - 1996/11/02	“Estudos de Separação de uma Proteína Recombinante por Processos de Membranas” PhD Chemical Engineering, Instituto Superior Técnico, November 1996 Supervisor of José António Leonardo dos Santos	Engenharia Química (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
1992/07/01 - 1996/07/01	"Separação e Purificação de Lipases por Processos Cromatográficos" PhD Biochemistry, University of Beira Interior, July, 1996 Supervisor of João António Rodrigues Queirós	Bioquímica (PhD) Universidade da Beira Interior, Portugal
1991/12/02 - 1995/12/02	"Produção, Purificação e Caracterização de Lipases de Penicillium citrinum" PhD Biochemistry, Federal University of Paraná, Brazil, December 1995 Supervisor	Bioquímica (PhD) Universidade Federal do Paraná Curso de Medicina, Brazil
1991/09/01 - 1995/09/01	"Actividade e Fluorescência de uma Cutinase Recombinante: Estudos em Micelas Invertidas e com a Técnica da Monocamada" PhD Biotechnology, Instituto Superior Técnico, September 1995 Supervisor of Eduardo José Xavier Rodrigues de Pinho e Melo	Biotecnologia e Biociências (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
1991/07/01 - 1995/07/01	"Produção e Purificação da Penicilina Acilase de Escherichia coli" PhD Biotechnology, Instituto Superior Técnico, July 1995 Supervisor of Luís Joaquim Pina da Fonseca	Biotecnologia e Biociências (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
1991/07/01 - 1995/07/01	"Separação e Purificação de uma Cutinase Recombinante Utilizando Sistemas Micelares" PhD Biotechnology, Instituto Superior Técnico, July 1995 Supervisor of Maria das Graças Carneiro da Cunha	Biotecnologia e Biociências (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
1990/07/01 - 1994/07/01	"Recuperação de Esteróides de Meios de Biotransformação por Processos de Membranas" PhD Chemical Engineering, Instituto Superior Técnico, July 1994 Supervisor of Marília Clemente Velez Mateus	Engenharia Química (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
1990/06/01 - 1994/06/01	"Cinética de Crescimento de Células em Suspensão de Cynara cardunculus em Reactores Biológicos" PhD Plant Biotechnology, University of Algarve, June, 1994 Supervisor of Maria Emília Lima Costa	Biotecnologia Vegetal (PhD) Universidade do Algarve - Campus de Gambelas, Portugal
1989/02/01 - 1993/02/01	"Estudo de Reactores Enzimáticos com Lipase Microencapsulada" PhD Chemical Engineering, Instituto Superior Técnico, February 1993 Supervisor of Duarte Miguel de França Teixeira Prazeres	Engenharia Química Instituto Superior Técnico, Universidade de Lisboa, Portugal
1989/01/02 - 1993/01/02	"Bioconversão de Esteróides com Células Imobilizadas de Arthrobacter simplex em Sistemas com Solventes Orgânicos" PhD Chemical Engineering, Instituto Superior Tecnico, January 1993 Supervisor of Helena Maria Rodrigues Vasconcelos Pinheiro	Engenharia Química (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
1988/02/01 - 1992/02/01	"Produção de Proteases e Metabolitos Secundários em Cultura de Células em Suspensão de Silybum marianum Gaertn." PhD Cell Biology, Faculty of Sciences, University of Lisbon, February 1992 Supervisor of Manuel Pedro Salema Fevereiro	Biologia Celular (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
1986/12/02 - 1990/12/02	"Extracção Líquido-Líquido de Produtos Biológicos: Recuperação de Produtos de Fermentação e Proteinas" PhD Chemical Engineering, Instituto Superior Técnico, December 1990 Supervisor of Maria Raquel Múrias dos Santos Aires-Barros	Engenharia Química (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal
1989/09/01 - 1989/09/01	"Extracção Líquido-Líquido de Proteínas Recombinantes com Sistemas de Micelas Invertidas" PhD Chemical Engineering, Instituto Superior Técnico, September, 1993 Supervisor of Mário José Lopes Pires	Engenharia Química (PhD) Instituto Superior Técnico, Universidade de Lisboa, Portugal

Committee member

	Activity description Role	Institution / Organization
2019/01 - 2019/01	Advancing Manufacture of Cell and Gene Therapies VI, Coronado, USA, January 2019 (Member of the Organising Committee) Member	Engineering Conferences International, United States
2018/04/24 - 2018/04/24	Stem Cell Community Day, Bioprocessing Technologies in Stem Cell Research: Perspectives on Process Design, Scale-Up, and Product Safety, Chaired by Joaquim M. S. Cabral, Dusseldorf, Germany, 24 April 2018. Director
2017/01 - 2017/01	Scale-Up and Manufacturing of Cell-Based Therapies V, San Diego, USA, January 2017 (Member of the Organising Committee) Member	Engineering Conferences International, United States
2015/01/18 - 2015/01/22	Scale-Up and Manufacturing of Cell-Based Therapies VI, San Diego, USA, 18 – 22 January 2015 (Member of the Organising Committee) Member	Engineering Conferences International, United States
2014/11 - 2014/11	6º curso teórico-prático de Cartila-gem Articular” Lisbon, Portugal, November 2014 (Member of the Scientific and Organising Committees) Member
2014/07/04 - 2014/07/05	4th International Symposium on Stem Cells and Cellular Therapy in Cardiovascular Diseases, Lisbon Summer School Meeting, 4 - 5 July 2014 (Member of the Organising Committee) Member
2014/01/05 - 2014/01/09	Scale-Up and Manufacturing of Cell-Based Therapies III, San Diego, USA, 5 – 9 January 2014 (Member of the Organising Committee) Member	Engineering Conferences International, United States
2013/11 - 2013/11	5º curso teórico-prático de Cartilagem Articular, Lisbon, Portugal, November 2013 (Member of the Scientific and Organising Committees) Member
2013/07/05 - 2013/07/06	3rd International Symposium on Stem Cells and Cellular Therapy in Cardiovascular Diseases, Lisbon Summer School Meeting, 5 - 6 July 2013 (Member of the Organising Committee) Member
2013/04 - 2013/05	Director of the International Advanced Course on Regenerative Medicine Manufacturing, Tavira, Algarve, Portugal, April/May 2013 Director	National Science Foundation, United States
2013/01/21 - 2013/01/23	Scale-Up and Manufacturing of Cell-Based Therapies II, San Diego, USA, 21 – 23 January 2013 (Member of the Organising Committee) Member	Engineering Conferences International, United States
2012/11/23 - 2012/11/24	4º curso teórico-prático de Cartilagem Articular, 23 – 24 November, Lisbon 2012 (Member of the Organising Committee) Member
2012/06/29 - 2012/06/30	2nd International Symposium on Stem Cells and Cellular Therapy in Cardiovascular Diseases, Lisbon Summer School Meeting, 29 – 30 June 2012 (Member of the Organising Committee) Member
2011/07/01 - 2011/07/02	1st International Symposium on Stem Cells and Cellular Therapy in Cardiovascular Diseases, (Member of the Organising Committee), Lisbon, Portugal, 1-2 July 2011 Member
2010/01 - 2010/01	2nd International Conference on Stem Cell Engineering, Boston, USA, January 2010 (Member of the Organising Committee) Member	American Institute of Chemical Engineers, United States
2009/04/29 - 2009/04/30	4th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies Lisboa, 29-30 April 2009 (Chairman of the Organising and Scientific Committees) Director	Sociedade Portuguesa de Células Estaminais e Terapias Celulares, Portugal
2008/09/07 - 2008/09/10	7th European Symposium on Biochemical Engineering Science ESBES-7, Faro, Portugal, 7-10 September 2008 (Member of the Organising and Scientific Committees) Member	ESBBES, Germany
2008/01/20 - 2008/01/23	1st International Conference on Stem Cell Engineering, Coronado Island, California, USA, 20-23 January 2008 (Member of the Organising Committee) Member	American Institute of Chemical Engineers, United States
2007/06 - 2007/07	7th International conference on Biopartitioning and Purification, BPP 2007 – Lisbon, Portugal, June 2007 (Chairman of the Organizing and Scientific Committees) Member
2000/04/09 - 2000/04/12	2nd International Conference on Protein Stabilization, Lisbon, Portugal, 9-12 April 2000 (Chairman of the Organising Committee and Member of the Scientific Committee) Director
1990/10 - 1999/10	5º Congresso Nacional de Biotecnologia, Braga, Portugal, October 1990 (Member of the Organising and Scientific Committees) Director	Sociedade Portuguesa de Biotecnologia, Portugal
1998/09 - 1998/09	2nd European Symposium on Biochemical Engineering Science, Porto, Portugal, September 1998 (Member of the Organising and Scientific Committees) Member	ESBES, Germany
1998/07 - 1998/07	Biotec’98, Guimarães, Portugal, July 1998 (Member of the Organising and Scientific Committees) Member	Sociedade Portuguesa de Biotecnologia, Portugal
1985/07 - 1995/07	Simpósio sobre Biocatalisadores Imobilizados” Lisboa, Portugal, July 1985 (Member of the Organising and Scientific Committees) Member	Sociedade Portuguesa de Biotecnologia, Portugal
1994/10 - 1994/10	II Congresso Ibérico de Biotecnologia – BIOTEC’94, Vilamoura, Portugal, October 1994 (Member of the Organising and Scientific Committees) Member	Sociedade Portuguesa de Biotecnologia, Portugal
1994/05 - 1994/05	European Science Foundation Conference on Bioseparation: Fundamental and Engineering Aspects of Protein Purification, Dourdan, France, May/June1994 (Chairman of the Organising Committee and Member of the Scientific Committee) Director
1992/09 - 1992/09	I Congresso Hispano-Luso de Biotecnologia – BIOTEC’92, Santiago de Compostela, Spain, September 1992 (Member of the Organising and Scientific Committees) Member	Sociedade Portuguesa de Biotecnologia, Portugal
1992/05 - 1992/05	European Science Foundation Conference on Bioseparation, Espinho, Portugal, May 1992 (Vice-Chairman of the Organising Committee and Member of the Scientific Committee) Director
1990/07 - 1990/07	NATO Advanced Study Institute on Chromatographic and Membrane Processes in Biotechnology, S.Miguel, Azores, Portugal, July 1990 (Vice Chairman of the Organising Committee and Member of the Scientific Committee) Director
1988/12 - 1988/12	4º Congresso Nacional de Biotecnologia, Coimbra, Portugal, December 1988 (Chairman of the Organising Committee and Member of the Scientific Committee) Director	Sociedade Portuguesa de Biotecnologia, Portugal

Conference scientific committee

	Conference name	Conference host
2020/09/17 - 2020/09/20	13th European Symposium on Biochemical Engineering Science ESBES 2020, Portorož, Slovenia, 17 -20 September 2020 (Member of the Scientific Committee)	European Society of Biochemical Engineering Science
2019/12/05 - 2019/12/07	MIcroBiotec19, National Congress on Microbiology and Biotechnology, Coimbra, Portugal, 5-7 December 2019, (Member of the Scientific Committee)	Sociedade Portuguesa de Biotecnologia
2019/10/10 - 2019/10/12	11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies), Lisbon, 10-12 October 2019 (Member of the Advisory Board)	Sociedade Portuguesa de Células Estaminais e Terapias Celulares
2019/09/15 - 2019/09/19	12th European Congress of Chemical Engineering (ECCE12)/ 5th European Congress of Applied Biotechnology – ECAB5, 2019 (Firenze, Italy) 15 -19 September 2019 (Member of the Coordinating Committee of the joint Congresses)	European Federation of Chemical Engineering (EFCE) and European Society of Biochemical Engineering Sciences (ESBES)
2018/09 - 2018/09	12th European Symposium of Biochemical Engineering Science ESBES 2018 (Lisbon, Portugal) September 2018 (Member of the Scientific Committee	European Society of Biochemical Engineering Science
2017/12/07 - 2017/12/09	MicroBiotec2017, National Congress on Microbiology and Biotechnology, Porto, Portugal, 7-9 December 2017 (Member of the Scientific Committee	Sociedade Portuguesa de Biotecnologia
2017/10/12 - 2017/10/14	10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Covilhã, 12-14 October 2017 (Member of the Scientific Committee)	Sociedade Portuguesa de Células Estaminais e Terapias Celulares
2017/10/01 - 2017/10/05	10th Congress of Chemical Engineering World 11th European Congress of Chemical Engineering (ECCE11)/ 4th European Congress of Applied Biotechnology - ECAB4, 2017 (Barcelona, Spain) 1- 5 October 2107 (Member of the Coordinating Committee of the joint Congresses)	World Chemical Engineering Council (WCEC), European Federation of Chemical Engineering (EFCE) and the European Society of Biochemical Engineering Sciences (ESBES)
2016/09 - 2016/09	11th European Symposium of Biochemical Engineering Science ESBES 2016 (Dublin, Ireland), September 2018 (Member of the Scientific Committee)	European Society of Biochemical Engineering Science
2015/12/10 - 2015/12/12	MicroBiotec2015, National Congress on Microbiology and Biotechnology, Évora, Portugal, 10-12 December 2015 (Member of the Scientific Committee)	Sociedade Portuguesa de Biotecnologia
2015/09 - 2015/09	10th European Congress of Chemical Engineering (ECCE10) / 3nd European Conference of Applied Biotechnology (ECAB3) Nice, September 2015 (Member of the Coordinating Committee of the joint Congresses)	European Federation of Chemical Engineering (EFCE) and European Society of Biochemical Engineering Science
2015/05/10 - 2015/05/13	3rd Conference on the Implementation of Microreactor Technology in Biotechnology (IMTB 2015), Opatija, Croatia 10-13th May 2015 (Member of the Scientific Committee)
2014/09 - 2014/09	10th European Symposium on Biochemical Engineering Science, ESBES - 10, Lille, France, September 2014 (Member of the Scientific Committee)	European Society of Biochemical Engineering Science
2013/12/06 - 2013/12/08	MicroBiotec2013, National Congress on Microbiology and Biotechnology, Aveiro, Portugal, 6-8 December 2013 (Member of the Scientific Committee)	Sociedade Portuguesa de Biotecnologia
2013/05/09 - 2013/05/10	8th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Faro,9-10 May 2013 (Member of the Scientific Committee)	Sociedade Portuguesa de Células Estaminais e Terapias Celulares
2013/04 - 2013/04	9th European Congress of Chemical Engineering (ECCE9) / 2nd European Conference of Applied Biotechnology (ECAB2) The Hague, The Netherlands, April 2013 (Member of the Coordinating Committee of the joint Congresses)	European Federation of Chemical Engineering (EFCE) and European Society of Biochemical Engineering Science
2012/09 - 2012/09	9th European Symposium on Biochemical Engineering Science, ESBES - 9, Istanbul, Turkey, September 2012 (Member of the Scientific Committee)	European Society of Biochemical Engineering Science
2012/05 - 2012/05	9th International Conference on Protein Stabilisation, Lisbon, Portugal, May 2012 (Member of the Scientific Committee)	Instituto Superior Técnico, University of Lisbon
2012/04/26 - 2012/04/27	7th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies Porto, 26-27 April 2012 (Member of the Scientific Committee)	Sociedade Portuguesa de Células Estaminais e Terapias Celulares
2012/02 - 2012/02	2nd Biotechnology World Congress, Dubai, UAE, February 2012 (Member of the International Advisory Board)
2011/12/01 - 2011/12/03	MicroBiotec2011, National Congress on Microbiology and Biotechnology, Braga, Portugal, 1-3 December 2011 (Member of the Scientific Committee)	Sociedade Portuguesa de Biotecnologia
2011/04/28 - 2011/04/29	6th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Cantanhede, 28-29 April 2011 (Member of the Scientific Committee)	Sociedade Portuguesa de Células Estaminais e Terapias Celulares
2010/09 - 2010/09	8th European Symposium on Biochemical Engineering Science ESBES - 8, Bologna, Italy, September 2010 (Member of the Scientific Committee)	European Society of Biochemical Engineering Science
2010/04/20 - 2010/04/21	5th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Braga, 20 – 21 April 2010 (Member of the Scientific Committee)	Sociedade Portuguesa de Células Estaminais e Terapias Celulares
2009/11/28 - 2009/11/30	MIcroBiotec09 National Congress on Microbiology and Biotechnology Vilamoura, Portugal 28-30 November 2009, (Member of the Scientific Committee)	Sociedade Portuguesa de Biotecnologia
2009/10/20 - 2009/10/22	European Forum for Industrial Biotechnology, Lisboa, 20-22 October 2009 (Member of the Advisory Committee)	European Forum for Industrial Biotechnology
2009/06/14 - 2009/06/19	International Conference on Biopartitioning and Purification, Brunel University, Uxbridge, UK, 14-19 June 2009 (Member of the Scientific Committee)	Brunel University
2008/09 - 2008/09	10th International Chemical and Biological Engineering Conference, CHEMPOR 2008, Braga, Portugal, September 2008 (Member of the Scientific Committee)	CHEMPOR
2008/06 - 2008/06	Annual Tissue Engineering and Regenerative Medicine International Society (TERMIS) – EU Meeting, Porto, Portugal, June 2008 (Member of the Scientific Committee)	Tissue Engineering and Regenerative Medicine International Society (TERMIS)
2008/04/23 - 2008/04/24	3rd Annual International Meeting of of the Portuguese Society for Stem Cells and Cell Therapies, Faro, 23-24 April 2008 (Member of the Scientific Committee)	Sociedade Portuguesa de Células Estaminais e Terapias Celulares
2007/11/30 - 2007/12/02	Micro’07-Biotec’07, National Congress on Microbiology and Biotechnology, Lisbon, Portugal, 30 November-2 December 2007 (Member of the Scientific Committee)	Sociedade Portuguesa de Biotecnologia
2007/04/27 - 2007/04/28	2nd Annual International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Coimbra, 27 -28 April 2007 (Member of the Scientific Committee)	Sociedade Portuguesa de Células Estaminais e Terapias Celulares
2006/08 - 2006/08	6th European Symposium on Biochemical Engineering Science ESBES-6, Salzburg, Austria, August 2006 (Member of the Scientific Committee)	European Society of Biochemical Engineering Science
2006/06/03 - 2006/06/04	1st Annual International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Funchal, 3-4 June 2006 (Member of the Scientific Committee)	Sociedade Portuguesa de Células Estaminais e Terapias Celulares
2005/11/30 - 2005/12/03	Micro’05-Biotec’05, National Congress on Microbiology and Biotechnology, Póvoa do Varzim, Portugal, 30 November- 3 December 2005 (Member of the Scientific Committee)	Sociedade Portuguesa de Biotecnologia
2005/08/21 - 2005/08/24	12th European Congress on Biotechnology, Copenhagen, Denmark, 21 –24 August 2005 (Member of the Scientific Committee)	European Federation of Biotechnology
2005/07/10 - 2005/07/14	7th World Congress and 5th European Congress on Chemical Engineering, Glasgow, Scotland, 10 – 14 July 2005 (Member of the Scientific Committee)
2004/10/17 - 2004/10/22	12th International Biotechnology Symposium, Santiago, Chile, 17 – 22 October 2004 (Member of the Scientific Committee)	International Society of Biotechnology
2004/09/08 - 2004/09/11	5th European Symposium on Biochemical Engineering Science, Stuttgart, Germany, 8-11 September 2004 (Member of the Scientific Committee)	European Society of Biochemical Engineering Science
2002/08/28 - 2002/08/31	4th European Symposium on Biochemical Engineering Science, Delft, The Netherlands, 28-31 August 2002 (Member of the Scientific Committee)	European Society of Biochemical Engineering Science
2002/04/21 - 2002/04/24	3rd International Conference on Protein Stabilization, Toulose, France, 21-24 April 2002 (Member of the Scientific Committee)	European Federation of Biotechnology
2001/07 - 2001/07	10th European Congress on Biotechnology, Madrid, Spain, July 2001(Member of the Scientific Committee)	European Federation of Biotechnology
2000/09/10 - 2000/09/13	3rd European Symposium on Biochemical Engineering Science, Copenhagen, Denmark, 10-13 September 2000 (Member of the Scientific Committee)	European Society of Biochemical Engineering Science
2000/07/16 - 2000/07/21	XVII Ibero-American Symposium on Catalysis, Porto, Portugal, 16-21 July 2000 (Member of the Scientific Committee)	Universidade do Porto
1999/07/04 - 1999/07/08	13th International Conference on Affinity Technology and Bio-Recognition, Compiègne, France, 4-8 July 1999 (Member of the Scientific Committee)	Université Technologie de Compiègne, France
1999/07 - 1999/07	9th European Congress on Biotechnology, Brussels, Belgium, July 1999 (Member of the Scientific Committee)	European Federation of Biotechnology
1999/03/29 - 1999/03/30	4th International Conference on Separations for Biotechnology, Reading, UK, 29-31 March 1999 (Member of the Scientific Committee)
1998/09 - 1998/09	CHEMPOR’98, Lisboa, September 1998 (Member of the Scientific Committee)	CHEMPOR
1998/07 - 1998/07	1st International Symposium on Enzyme Stabilisation, Leeds, UK, July 1998 (Member of the Scientific Committee)	University of Leeds, UK
1998/04 - 1998/04	Symposium on Stability and Stabilisation of Biocatalysts, Cordoba, Spain, April 1998 (Member of the Scientific Committee)	European Federation of Biotechnology
1996/09 - 1996/09	BIOTEC’96, Vlladolid, Spain, September 1996 (Member of the Scientific Committee)	Sociedade Portuguesa de Biotecnologia
1996/09 - 1996/09	1st European Symposium on Biochemical Engineering Science, Dublin, Ireland, September 1996 (Member of the Scientific Committee)	European Society of Biochemical Engineering Science
1995/11 - 1995/11	Immobilized Cells, Noordwijerhout, The Netherlands, November 1995 (Member of the Scientific Committee)	European Federation of Biotechnology
1995/02 - 1995/02	7th European Congress on Biotechnology, Nice, France, February 1995 (Member of the Scientific Committee)	European Federation of Biotechnology
1994/10 - 1994/10	Recombinant DNA Biotechnology III, Deauville, France, October 1994 (Member of the Scientific Committee)	Engineering Conferences International
1993/09 - 1993/09	12nd International Enzyme Engineering Conference, Deauville, France, September 1993 (Member of the Scientific Committee)	Engineering Conferences International
1993/06 - 1993/06	6th European Congress on Biotechnology, Firenze, Italy, June 1993 (Member of the Scientific Committee)	European Federation of Biotechnology
1993/03 - 1993/03	Simpósio Nacional de Microbiologia Aplicada e Biotecnologia”, Luso, Portugal, March 1993 (Member of the Scientific Committee)	Sociedade Portuguesa de Biotecnologia
1992/11 - 1992/11	International Symposium on Stability and Stabilization of Enzymes, Maastricht, The Netherlands November 1992 (Member of the Scientific Committee)	European Federation of Biotechnology
1992/04 - 1992/04	Fundamentals of Biocatalysis in Non Conventional Media, Noordwijkerhout, The Netherlands, April 1992 (Member of the Scientific Committee)	European Federation of Biotechnology
1990/07 - 1990/07	5th European Congress on Biotechnology, Copenhagen, Denmark, July 1990 (Member of the Scientific Committee)	European Federation of Biotechnology
1989/12 - 1989/12	International Symposium on Physiology of Immobilized Cells, Wageningen, The Netherlands, December 1989 (Member of the Scientific Committee)	European Federation of Biotechnology
1987/12 - 1987/12	8º Congresso Nacional de Bioquímica, Póvoa de Varzim, Portugal, December 1987 (Member of the Scientific Committee)	Sociedade Portuguesa de Bioquímica
1986/12/06 - 1986/12/09	10º Congresso Nacional de Biotecnologia”, Lisboa, Portugal, 6 – 8 December 2003 (Member of the Scientific Committee)	Sociedade Portuguesa de Biotecnologia
1986/12 - 1986/12	International Symposium on Biocatalysis in Organic Media Wageningen, The Netherlands, December 1986 (Member of the Scientific Committee)
1986/10 - 1986/10	3º Encontro Nacional de Biotecnologia”, Lisboa, Portugal, October 1986 (Member of the Scientific Committee)	Sociedade Portuguesa de Biotecnologia

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2014/02 - Current	Coordinator PhD Programme in Bioengineering- Specilaities: Bioengineering Systems and Cellular Therapies and Regenerative Medicine	Bioengenharia (Doutoramento)	Instituto Superior Técnico, Universidade de Lisboa, Portugal

Scientific expedition

	Activity description	Institution / Organization
2019/12 - Current	Population-Level Dynamics of Human Pluripotent Stem Cell Fate Transitions

Distinctions

Award

2023	Júlio Novais Award Portuguese Society of Biotechnology
2022	Career Award Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal
2005	Honorary Member, Section on Applied Biocatalysis, European Federation of Biotechnology European Federation of Biotechnology, Germany
2004	Estimulo à Excelência, Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia, I.P., Portugal
2001	Prize “União Latina” Universidade Técnica de Lisboa, Portugal
1983	NATO post-doctoral fellow Massachusetts Institute of Technology, USA INVOTAN, Portugal
1983	Fulbright post-doctoral fellow Massachusetts Institute of Technology, USA PT-US Fulbright Commission, Portugal

Title

2024	Emmeritus Professor
2015	Distinguished Professorship, Instituto Superior Técnico, University of Lisbon Instituto Superior Técnico, Universidade de Lisboa, Portugal