M Matilde Marques (AB1A-1A93-03C0)

Curriculum Vitae

M Matilde Marques

M. Matilde Marques was born in Santarém, Portugal. She holds B.S. and Ph.D. degrees in chemical engineering and a Habilitation degree (D.Sc.) in chemistry from Instituto Superior Técnico (IST), University of Lisbon, Portugal. She conducted postdoctoral work in chemical carcinogenesis at the FDA National Center for Toxicological Research, USA, and is currently a full professor at the Department of Chemical Engineering of IST, where she teaches organic and medicinal chemistry. She coordinated the M.S. and Ph.D. Chemistry Programs at IST until December 2016 and is currently vice-chair of IST¿s Scientific Council. Her research focuses on the mechanisms of toxicity induced by environmental (e.g., aromatic amines, acrylamide) and therapeutic (e.g., antiestrogens, anti-HIV drugs) xenobiotics, on the development/validation of analytical methodologies for the detection and quantitation of biomarkers of exposure to toxic agents, with emphasis on MS-based methodologies, and on the design, synthesis, and biological evaluation of potential therapeutic agents. She is a Member of the American Association for Cancer Research, the American Chemical Society, and the Royal Society of Chemistry. She has chaired the Division of Medicinal Chemistry of the Portuguese Chemical Society (2016-2020) and has been Council Member of the European Federation for Medicinal Chemistry (EFMC) (2016-2020). She has served (2008-2022) on the Editorial Advisory Board for Chemical Research in Toxicology, currently serves on the editorial board of Pharmaceuticals, and has been a Member of multiple working groups for the International Agency for Research on Cancer.

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Identification

Personal identification

Full name: M Matilde Marques

Citation names

Marques, M Matilde

Author identifiers

Ciência ID: AB1A-1A93-03C0
ORCID iD: 0000-0002-7526-4962
Google Scholar ID: https://scholar.google.pt/citations?user=A4CX5p0AAAAJ&hl=pt-PT
Researcher Id: E-2535-2012
Scopus Author Id: 35492817000

Email addresses

matilde.marques@tecnico.ulisboa.pt (Professional)

Telephones

Telephone

218419200 (Professional)

Addresses

Centro de Química Estrutural, IST, Av. Rovisco Pais, 1, 1049-001, Lisboa, Lisboa, Portugal (Professional)

Websites

https://fenix.tecnico.ulisboa.pt/homepage/ist11938 (Professional)

Knowledge fields

Exact Sciences - Chemical Sciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
French	Advanced (C1)	Proficiency (C2)	Upper intermediate (B2)	Proficiency (C2)	Advanced (C1)
Spanish; Castilian	Elementary (A2)	Advanced (C1)	Elementary (A2)	Advanced (C1)	Intermediate (B1)

Education

	Degree	Classification
2004/10/27 Concluded	M. Matilde Marques (Título de Agregado) Major in Chemistry Universidade de Lisboa Instituto Superior Técnico, Portugal	Unanimity
1987 Concluded	Engenharia Química (Doutoramento) Major in Sem especialidade Universidade de Lisboa Instituto Superior Técnico, Portugal "Reactividade e Aplicações Sintéticas de Hidroxilaminas e Derivados" (THESIS/DISSERTATION)	Distinção e Louvor
1979 Concluded	M. Matilde Marques (Licenciatura) Major in Chemical Engineering Universidade de Lisboa Instituto Superior Técnico, Portugal	17/20

Affiliation

Science

	Category Host institution	Employer
1987 - 1988	Postdoc (Research)	National Center for Toxicological Research, United States

Teaching in Higher Education

	Category Host institution	Employer
2016 - Current	Full Professor (University Teacher)	Universidade de Lisboa Instituto Superior Técnico, Portugal
	Universidade de Lisboa Instituto Superior Técnico, Portugal
1995 - 2015	Associate Professor (University Teacher)	Universidade de Lisboa Instituto Superior Técnico, Portugal

1987 - 1995	Assistant Professor (University Teacher)	Universidade de Lisboa Instituto Superior Técnico, Portugal

Positions / Appointments

	Category Host institution	Employer
2017 - 2024/12/31	Conselho científico (vice-presidente)	Universidade de Lisboa Instituto Superior Técnico, Portugal

2008 - 2023/12/31	Coordenação ou direção de centro de investigação, departamento ou equivalente	Universidade de Lisboa Centro de Química Estrutural, Portugal

2013 - 2016	Conselho pedagógico	Universidade de Lisboa Instituto Superior Técnico, Portugal

Projects

Contract

	Designation	Funders
2018/10/01 - 2022/09/30	From Drug Design to Chemical Toxicology: shaping predictive tools with Mass Spectrometry PTDC/QUI-QAN/32242/2017 Principal investigator Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/09/01 - 2022/08/31	Fighting metastatic cancers: prime time for ruthenium PTDC/QUI-QIN/28662/2017 Researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade do Minho, Portugal Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2017/01/01 - 2021/06/30	PRECISION ONCOLOGY BY INNOVATIVE THERAPIES AND TECHNOLOGIES SAICTPAC/0019/2015 Researcher Universidade de Lisboa Faculdade de Farmácia, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal INESC Microsistemas e Nanotecnologias, Portugal Instituto Politécnico de Leiria, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2013/06/01 - 2016/12/31	From small bioactive molecules to an integrated OMICS approach: Mass Spectrometry tools for mechanistic insights into drug-like and functional properties, toxicity, and stress responses RECI/QEQ-MED/0330/2012 Principal investigator Universidade de Lisboa Centro de Química Estrutural, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Centro Hospitalar de Lisboa Central EPE, Portugal Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal Hospital Professor Doutor Fernando Fonseca EPE, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/06/01 - 2016/12/31	From drug design to new materials: structural approach in emergent fields RECI/QEQ-QIN/0189/2012 Researcher Universidade de Lisboa Centro de Química Estrutural, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/03/15 - 2014/09/14	Hepatic toxicity in HIV-infected individuals exposed to nevirapine PTDC/SAU-TOX/111663/2009 Researcher Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Centro Hospitalar de Lisboa Central EPE, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/02/01 - 2014/07/31	Bioactivation routes of the anti-HIV drug Nevirapine: identification of reactive metabolites and mutagenic potential PTDC/QUI-QUI/113910/2009 Principal investigator Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade de Lisboa Centro de Química Estrutural, Portugal Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/02/01 - 2013/07/31	BIOMARKERS OF DIETARY ACRYLAMIDE EXPOSURE: HUMAN TOXICOLOGICAL RELEVANCE. PTDC/SAU-OSM/105572/2008 Researcher Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/02/01 - 2013/04/30	Electron Transfer in Organic Mixed-Valence Radical-Ions PTDC/QUI-QUI/101433/2008 Researcher Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade de Lisboa Centro de Química Estrutural, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/01/02 - 2012/06/30	Novel bioorganometallic SERM analogues - synthesis and evaluation of anti-cancer potential PTDC/QUI/67522/2006 Principal investigator Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade de Lisboa Centro de Química Estrutural, Portugal Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008 - 2009	Genetic Lesion Induced by Acrylamide: What Is the Relevance for Mammary, Thyroid, and Central Nervous System Carcinogenesis?; nn Researcher Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal	Fundação Calouste Gulbenkian Concluded
2005/10/15 - 2008/06/30	BREAST CANCER: EVALUATION OF THE ROLE OF ENVIRONMENTAL AND FOOD CARCINOGENS IN ITS INITIATION POCI/QUI/57110/2004 Principal investigator Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade de Lisboa Centro de Química Estrutural, Portugal Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/10/01 - 2008/06/30	Controlling pharmaceuticals behaviour by Crystal Engineering POCI/QUI/58791/2004 Researcher Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade de Lisboa Centro de Química Estrutural, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/09/15 - 2008/06/30	Anti-HIV Drugs: Genotoxic Evaluation and Synthetic Strategies POCI/QUI/56582/2004 Principal investigator Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade de Lisboa Centro de Química Estrutural, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007 - 2008	Characterization of Biological Factors and Lifestyles with Impact on the Occurrence and Types of Cancer Identification of Risk Factors for Primary Tumors of the Central Nervous System nn Researcher Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal	Fundação Calouste Gulbenkian Concluded
2001 - 2005	Evaluation of the Genotoxic and AntiEstrogenic Potential of Triphenyethylene Derivatives and their Metabolites POCTI/33544/QUI/2000 Principal investigator Universidade de Lisboa Centro de Química Estrutural, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1997 - 2000	DNA Interaction with Tamoxifen Metabolites PRAXIS/PCEX/C/QUI/51/96 Principal investigator Universidade de Lisboa Centro de Química Estrutural, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1996 - 1997	DNA adducts of tamoxifen nn Invited Scientist Fellow National Center for Toxicological Research, United States	Food and Drug Administration Office of Women's Health Concluded
1996 - 1997	DNA Adduct Structure: Effects on Mutation Induction CRG960165 Principal investigator Universidade de Lisboa Centro de Química Estrutural, Portugal	NATO Concluded
1992 - 1995	Chemical Modification of DNA: Characterization and Conformational Analysis of the Products PBIC/C/CEN/1154/92 Principal investigator Universidade de Lisboa Centro de Química Estrutural, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1992 - 1994	Synthesis and Molecular Recognition of Nucleosides Modified with Carcinogenic Agents STRDA/C/AMB/347/92 Researcher Universidade de Lisboa Centro de Química Estrutural, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1992 - 1994	O-Acetylation of carcinogenic N-hydroxyarylamines CRG910561 Principal investigator Universidade de Lisboa Centro de Química Estrutural, Portugal	NATO Concluded

Outputs

Publications

Book	Allen, N.; Anderson, L.M.; Beland, F.A.; Bénichou, J.; Beral, V.; Bloomfield, K.; Brooks, P.J.; et al. Alcohol consumption and ethyl carbamate. 2010.
Book chapter	Beland, F. A.; Camacho L; Marques, M Matilde. "Polycyclic Aromatic Hydrocarbons, Methylated Polycyclic Aromatic Hydrocarbons, and Polycyclic Azaaromatic Compounds". In Patty's Toxicology, edited by Paustenbach DJ; Farland DH; Klaunig J; Levy L. New York, United States: John Wiley & Sons, Inc, 2024. In press Cátia F. Marques; Marques, M Matilde. "Pharmacometabolomics in Drug Discovery and Development". In Systems Medicine: Integrative, Qualitative and Computational Approaches. Elsevier, 2020. In press Marques, M Matilde; Beland, F.A.. "Aromatic amines and aristolochic acids Tumour Site Concordance and Mechanisms of Carcinogenesis". In Tumour Site Concordance and Mechanisms of Carcinogenesis - IARC Scientific Publication, edited by Baan, R. A.; Stewart, B. W.; Straif, K., 23-30. Lyon, France: International Agency for Research on Cancer, 2019. Published Beland, F.A.; Marques, M.M.. "DNA adducts of nitropolycyclic aromatic hydrocarbons.". In IARC scientific publications, 229-244. 1994. Marques, M.M.; Beland, F.A.. "DNA adducts of aromatic amines present in tobacco smoke.". In IARC scientific publications, 453-456. 1994.
Conference abstract	M. Matilde Marques; ALA Godinho; MC Oliveira; SA Pereira; EC Monteiro; FA Beland; AMM Antunes. "Mass spectrometric detection of hemoglobin adducts from the anti-HIV drug nevirapine and its metabolite 12-hydroxy-nevirapine in rats". Paper presented in ACS National Meeting, Boston, 2010. Published M.M. Marques; C. Charneira; A.M. Antunes. "Protein adduct formation: A possible factor in hypersensitivity reactions induced by the anti HIV drug abacavir". Paper presented in IUTOX2010, Barcelona, 2010. Published • 10.1016/J.TOXLET.2010.03.390 M. Matilde Marques; Alexandra M.M. Antunes; Muna C. Sidarus; Frederick A. Beland. "Chemical and enzymatic oxidation of 2-hydroxynevirapine, a metabolite of the HIV-1 reverse transcriptase inhibitor nevirapine". Paper presented in Eurotox2009, Dresden, 2009. Published • 10.1016/J.TOXLET.2009.06.333 Alexandra M.M. Antunes; Ana Godinho; M. Matilde Marques; Inês Martins; Frederick A. Beland. "Protein adduct formation by the nevirapine metabolite, 12-hydroxynevirapine—A possible factor in nevirapine toxicity". Paper presented in Eurotox2009, Dresden, 2009. Published • 10.1016/J.TOXLET.2009.06.334
Conference paper	Marques, M. "Adverse reactions induced by the antiepileptic drug oxcarbazepine may stem from its metabolic biotransformation to carbamazepine". 2018. Published Li, L.; Chiarelli, M.P.; Branco, P.S.; Antunes, A.M.; Marques, M.M.; Gonçalves, L.L.; Beland, F.A.. "Differentiation of isomeric arylamine adducts of deoxyguanosine by electrospray ionization and quadrupole ion trap mass spectrometry". 2002. Published
Journal article	Riboli, Elio; Beland, Frederick A; Lachenmeier, Dirk W; Marques, M Matilde; Phillips, David H; Schernhammer, Eva; Afghan, Abdul; et al. "Carcinogenicity of aspartame, methyleugenol, and isoeugenol". The Lancet Oncology 24 8 (2023): 848-850. http://dx.doi.org/10.1016/s1470-2045(23)00341-8. Published • 10.1016/s1470-2045(23)00341-8 Marques, Cátia F.; Marques, M. Matilde; Justino, Gonçalo C.. "The mechanisms underlying montelukast's neuropsychiatric effects - new insights from a combined metabolic and multiomics approach". Life Sciences 310 (2022): 121056. http://dx.doi.org/10.1016/j.lfs.2022.121056. Published • 10.1016/j.lfs.2022.121056 Cátia F. Marques; Maria Matilde Marques; Gonçalo C. Justino. "Leukotrienes vs. Montelukast—Activity, Metabolism, and Toxicity Hints for Repurposing". Pharmaceuticals (2022): https://doi.org/10.3390/ph15091039. 10.3390/ph15091039 M. Emília Sousa; M. Matilde Marques; M. Amparo F. Faustino. "1st Spring Virtual Meeting on Medicinal Chemistry". Chemistry Proceedings (2021): https://doi.org/10.3390/chemproc2021004001. 10.3390/chemproc2021004001 Leitão, Inês; Martins, Luisa L.; Carvalho, Luisa; Oliveira, M. Conceição; Marques, M. Matilde; Mourato, Miguel P.. "Acetaminophen Induces an Antioxidative Response in Lettuce Plants". Plants 10 6 (2021): 1152. http://dx.doi.org/10.3390/plants10061152. 10.3390/plants10061152 Leitão, Inês; Mourato, Miguel Pedro; Carvalho, Luísa; Oliveira, Maria Conceição; Marques, Maria Matilde; Martins, Luisa Louro. "Antioxidative response of lettuce (Lactuca sativa) to carbamazepine-induced stress". Environmental Science and Pollution Research (2021): http://dx.doi.org/10.1007/s11356-021-13979-3. Published • 10.1007/s11356-021-13979-3 Harjivan, Shrika G.; Charneira, Catarina; Martins, Inês L.; Pereira, Sofia A.; Espadas, Guadalupe; Sabidó, Eduard; Beland, Frederick A.; Marques, M. Matilde; Antunes, Alexandra M. M.. "Covalent Histone Modification by an Electrophilic Derivative of the Anti-HIV Drug Nevirapine". Molecules 26 5 (2021): 1349. http://dx.doi.org/10.3390/molecules26051349. Open access • Published • 10.3390/molecules26051349 Ramilo-Gomes, Filipa; Addis, Yemataw; Tekamo, Israel; Cavaco, Isabel; Campos, Débora L.; Pavan, Fernando R.; Gomes, Clara S.B.; et al. "Antimicrobial and antitumor activity of S-methyl dithiocarbazate Schiff base zinc(II) complexes". Journal of Inorganic Biochemistry 216 (2021): 111331. http://dx.doi.org/10.1016/j.jinorgbio.2020.111331. Published • 10.1016/j.jinorgbio.2020.111331 Marques, M Matilde; Beland, Frederick A; Lachenmeier, Dirk W; Phillips, David H; Chung, Fung-Lung; Dorman, David C; Elmore, Sarah E; et al. "Carcinogenicity of acrolein, crotonaldehyde, and arecoline". The Lancet Oncology 22 1 (2021): 19-20. http://dx.doi.org/10.1016/s1470-2045(20)30727-0. 10.1016/s1470-2045(20)30727-0 Marinho, Aline T.; Batuca, Joana R.; Miranda, Joana P.; Caixas, Umbelina; Dias, Clara G.; Branco, Teresa; Soto, Karina; et al. "The 2-hydroxy-nevirapine metabolite as a candidate for boosting apolipoprotein A1 and for modulating anti-HDL antibodies". Pharmacological Research (2021): 105446. http://dx.doi.org/10.1016/j.phrs.2021.105446. In press • 10.1016/j.phrs.2021.105446 Inês Leitão; Miguel P. Mourato; Joana Sales; Maria Matilde Marques; Maria Conceição Oliveira; Luisa L. Martins. "Effects of Metformin on Antioxidative Response of Lactuca sativa Plants". Biology and Life Sciences Forum (2020): https://doi.org/10.3390/IECPS2020-08771. 10.3390/IECPS2020-08771 Pinheiro, Pedro F.; Justino, Gonçalo C.; Marques, M. Matilde. "NKp30 - A prospective target for new cancer immunotherapy strategies". British Journal of Pharmacology 177 20 (2020): 4563-4580. http://dx.doi.org/10.1111/bph.15222. 10.1111/bph.15222 Cipriano, Madalena; Pinheiro, Pedro F; Sequeira, Catarina O; Rodrigues, Joana S; Oliveira, Nuno G; Antunes, Alexandra M M; Castro, Matilde; et al. "Nevirapine Biotransformation Insights: An Integrated In Vitro Approach Unveils the Biocompetence and Glutathiolomic Profile of a Human Hepatocyte-Like Cell 3D Model". International Journal of Molecular Sciences 21 11 (2020): 3998. http://dx.doi.org/10.3390/ijms21113998. Open access • Published • 10.3390/ijms21113998 Mahgoub, Mohamed Y.; Elmaghraby, Awatef M.; Harb, Abd-Elfttah A.; Ferreira da Silva, João L.; Justino, Gonçalo C.; Marques, M. Matilde. "Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-a]Pyrimidines as New Acetylcholinesterase Inhibitors". Molecules 24 12 (2019): 2306. http://dx.doi.org/10.3390/molecules24122306. Open access • Published • 10.3390/molecules24122306 Braga, Cláudia; Vaz, Ana R.; Oliveira, M. Conceição; Matilde Marques, M.; Moreira, Rui; Brites, Dora; Perry, Maria J.. "Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability". European Journal of Medicinal Chemistry 172 (2019): 16-25. http://dx.doi.org/10.1016/j.ejmech.2019.03.048. Published • 10.1016/j.ejmech.2019.03.048 Marques, M Matilde; Berrington de Gonzalez, Amy; Beland, Frederick A.; Browne, Patience; Demers, Paul A; Lachenmeier, Dirk W; Bahadori, Tina; et al. "Advisory Group recommendations on priorities for the IARC Monographs". The Lancet Oncology 20 6 (2019): 763-764. http://dx.doi.org/10.1016/s1470-2045(19)30246-3. 10.1016/s1470-2045(19)30246-3 Marinho, Aline T.; Miranda, Joana P.; Caixas, Umbelina; Charneira, Catarina; Gonçalves-Dias, Clara; Marques, M. Matilde; Monteiro, Emília C.; Antunes, Alexandra M. M.; Pereira, Sofia A.. "Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity". Drug Metabolism Reviews 51 1 (2019): 76-90. http://dx.doi.org/10.1080/03602532.2019.1577891. Published • 10.1080/03602532.2019.1577891 Garcia, Sara N.; Guedes, Rita C.; Marques, M. Matilde. "Unlocking the Potential of HK2 in Cancer Metabolism and Therapeutics". Current Medicinal Chemistry 26 41 (2019): 7285-7322. http://dx.doi.org/10.2174/0929867326666181213092652. 10.2174/0929867326666181213092652 Kromhout, Hans; Friesen, Melissa; Marques, M Matilde; Sergi, Consolato Maria; Abdallah, Mohamed; Benke, Geza; Cesta, Mark; et al. "Carcinogenicity of isobutyl nitrite, ß-picoline, and some acrylates". The Lancet Oncology 19 8 (2018): 1020-1022. http://dx.doi.org/10.1016/s1470-2045(18)30491-1. Published • 10.1016/s1470-2045(18)30491-1 Godinho, Ana L.A.; Martins, Inês L.; Nunes, João; Charneira, Catarina; Grilo, Jorge; Silva, Diogo M.; Pereira, Sofia A.; et al. "High resolution mass spectrometry-based methodologies for identification of Etravirine bioactivation to reactive metabolites: In vitro and in vivo approaches". European Journal of Pharmaceutical Sciences 119 (2018): 70-82. http://dx.doi.org/10.1016/j.ejps.2018.03.026. 10.1016/j.ejps.2018.03.026 Marques, M. "Predicting drug metabolites using bacterial-based models". Abstracts of Papers of the American Chemical Society (2018): https://publons.com/publon/14992590/. Marques, M. "Inducing the activity of NK cells with NKp30 small organic ligands". Abstracts of Papers of the American Chemical Society (2018): https://publons.com/publon/14992591/. Martins, IL; Nunes, J; Charneira, C; Morello, J; Telo, JP; MARQUES, MM; Antunes, AMM. "The first-line antiepileptic drug carbamazepine: Reaction with biologically relevant free radicals". Free Radical Biology and Medicine 129 (2018): 559-568. https://doi.org/10.1016/j.freeradbiomed.2018.10.408. Published • 10.1016/J.FREERADBIOMED.2018.10.408 Grilo, Nádia M.; João Correia, M.; Miranda, Joana P.; Cipriano, Madalena; Serpa, Jacinta; Matilde Marques, M.; Monteiro, Emília C.; et al. "Unmasking efavirenz neurotoxicity: Time matters to the underlying mechanisms". European Journal of Pharmaceutical Sciences 105 (2017): 47-54. http://dx.doi.org/10.1016/j.ejps.2017.05.010. 10.1016/j.ejps.2017.05.010 Von Tungeln, Linda S.; Walker, Nigel J.; Olson, Greg R.; Mendoza, Maria C.B.; Felton, Robert P.; Thorn, Brett T.; Marques, M. Matilde; et al. "Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study". Food and Chemical Toxicology 99 (2017): 170-181. http://dx.doi.org/10.1016/j.fct.2016.11.015. Published • 10.1016/j.fct.2016.11.015 Alexandra Antunes. "Evidence of bioactivation of the anti-HIV drug etravirine to reactive metabolites in vitro and in vivo". Abstracts of Papers of the American Chemical Society (2017): https://publons.com/publon/18184341/. M. Matilde Marques; J. Paulo Telo; Inês L. Martins; Alexandra M.M. Antunes. "Toxic events induced by the antiepileptic drug carbamazepine: Is bioactivation really involved?". Toxicology Letters (2017): https://publons.com/publon/11121400/. 10.1016/J.TOXLET.2017.07.669 Pinheiro, Pedro F.; Pereira, Sofia A.; Harjivan, Shrika G.; Martins, Inês L.; Marinho, Aline T.; Cipriano, Madalena; Jacob, Cristina C.; et al. "Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study". Archives of Toxicology 91 3 (2017): 1199-1211. http://dx.doi.org/10.1007/s00204-016-1792-x. Published • 10.1007/s00204-016-1792-x Alexandra Antunes. "Reaction of the antiepileptic drug carbamazepine with bionucleophiles: Bioactivation is not required". Abstracts of Papers of the American Chemical Society (2017): https://publons.com/publon/18184342/. Joana P. Miranda; Sofia A. Pereira; Matilde Castro; Joana S. Rodrigues; M. Matilde Marques; Alexandra M.M. Antunes; Nuno G. Oliveira; et al. "3D in vitro cultures of human hepatocyte-like cells as an alternative competent model for nevirapine biotransformation studies". Toxicology Letters (2017): https://publons.com/publon/11121401/. 10.1016/J.TOXLET.2017.07.932 Grilo, N.M.; Correia, M.J.; Sequeira, C.; Harjivan, S.G.; Caixas, U.; Diogo, L.N.; Marques, M.M.; et al. "Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients". Toxicology Letters 260 (2016): 28-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987995250&partnerID=MN8TOARS. 10.1016/j.toxlet.2016.08.009 Marinho, A.T.; Dias, C.G.; Pinheiro, P.F.; Lemos, A.R.; Antunes, A.M.M.; Marques, M.M.; Monteiro, E.C.; et al. "Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach". European Journal of Pharmaceutical Sciences 82 (2016): 147-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949024137&partnerID=MN8TOARS. 10.1016/j.ejps.2015.11.019 Alexandra Antunes. "Monitoring of 8-hydroxy-efavirenz concentrations for management of mood changes". Journal of the International AIDS Society (2016): https://publons.com/publon/18184287/. C.C. Jacob; M. Marques; F.A. Beland; A. De Conti; I. Pogribny; C. Charneira; I.L. Martins; J. Nunes; Alexandra Antunes. "Modification of histone H2b in a rat model by a reactive metabolite of the chemical carcinogen and food contaminant furan". Toxicology Letters (2016): https://publons.com/publon/18184288/. 10.1016/J.TOXLET.2016.06.1405 M. Matilde Marques. "New small organic ligands for the natural cytotoxicity receptor NKp30". Abstracts of Papers of the American Chemical Society (2016): https://publons.com/publon/19002048/. J. Nunes; R.F. Gomes; M. Matilde Marques. "Synthesis and characterization of biomarkers of exposure to 1-bromopropane". Toxicology Letters (2016): https://publons.com/publon/19002059/. 10.1016/J.TOXLET.2016.06.1368 Grosse, Yann; Loomis, Dana; Guyton, Kathryn Z.; El Ghissassi, Fatiha; Bouvard, Veronique; Benbrahim-Tallaa, Lamia; Mattock, Heidi; Straif, Kurt; Int Agcy Res Canc. "Carcinogenicity of some industrial chemicals". Lancet Oncology 17 4 (2016): 419-420. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000373497600040&KeyUID=WOS:000373497600040. 10.1016/S1470-2045(16)00137-6 Alexandra M.M. Antunes; Frederick A. Beland; Aline de Conti; Igor P. Pogribny; Inês L. Martins; João Nunes; Cristina C. Jacob; M. Matilde Marques; Catarina Charneira. "New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan". Toxicology Letters (2016): https://publons.com/publon/4396379/. 10.1016/J.TOXLET.2016.10.018 Frederick A. Beland; Greg R. Olson; Maria C.B. Mendoza; M. Matilde Marques; Daniel R. Doerge. "Carcinogenicity of glycidamide in B6C3F 1 mice and F344/N rats from a two-year drinking water exposure". Food and Chemical Toxicology 86 (2015): 104-115. https://doi.org/10.1016%2Fj.fct.2015.09.017. 10.1016/J.FCT.2015.09.017 Godinho, A.; Surratt, G.; Gamboa da Costa, G.; Beland, F. A.; Antunes, A. M. M.; Marques, M. M.. "Metabolic activation of the nevirapine metabolite 12-hydroxy-nevirapine to 12-formylnevirapine - A possible factor in nevirapine toxicity". Toxicology Letters 238 2 (2015): S360-S361. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370693801860&KeyUID=WOS:000370693801860. 10.1016/J.TOXLET.2015.08.1027 Harjivan, S. G.; Wanke, R.; Woodling, K.; Gamboa da Costa, G.; Beland, F. A.; Antunes, A. M. M.; Marques, M. M.. "First in vitro evidence for a catechol metabolite from the anti-HIV drug efavirenz - A plausible role in toxicity". Toxicology Letters 238 2 (2015): S360-S360. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370693801859&KeyUID=WOS:000370693801859. 10.1016/J.TOXLET.2015.08.1026 Martins, I.; Marques, M. M.; Antunes, A.. "Protein adducts from carbamazepine-10,11-epoxide, the major metabolite of the antiepileptic drug carbamazepine: possible biomarkers of toxicity". Toxicology Letters 238 2 (2015): S359-S359. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370693801857&KeyUID=WOS:000370693801857. 10.1016/j.toxlet.2015.08.1024 Mahgoub, M. Y.; Cavaca, L.; Beland, F. A.; Marques, M. M.. "Activation of aloe-emodin to biologically plausible electrophiles - Possible role in the carcinogenicity of aloe vera whole leaf extracts". Toxicology Letters 238 2 (2015): S359-S359. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370693801856&KeyUID=WOS:000370693801856. 10.1016/j.toxlet.2015.08.1023 Harjivan, S. G.; Pinheiro, P. F.; Martins, I. L.; Novais, D. A.; Wanke, R.; Santos, P. P.; Pereira, S. A.; et al. "Enzymatic bioactivation of the phenolic nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine to quinoid intermediates: Covalent adduct formation with nitrogen-based amino acids". Toxicology Letters 238 2 (2015): S359-S360. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370693801858&KeyUID=WOS:000370693801858. 10.1016/j.toxlet.2015.08.1025 E.C. Monteiro; M.M. Marques; U. Caixas; T. Branco; S. Maia; M. Fonseca; S.G. Harjivan; et al. "Anti-histone antibodies in HIV-infected patients on Nevirapine-containing ANTIRETROVIRAL THERAPY". Clinical Therapeutics (2015): https://publons.com/publon/11121394/. 10.1016/J.CLINTHERA.2015.05.408 Pinheiro, P.F.; Marinho, A.T.; Antunes, A.M.M.; Marques, M.M.; Pereira, S.A.; Miranda, J.P.. "Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats". Chemico-Biological Interactions 233 (2015): 115-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926657811&partnerID=MN8TOARS. 10.1016/j.cbi.2015.03.024 Harjivan, S.G.; Pinheiro, P.F.; Martins, I.L.; Godinho, A.L.; Wanke, R.; Santos, P.P.; Pereira, S.A.; et al. "Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: Activation pathway to amino acid adducts". Toxicology Research 4 6 (2015): 1565-1577. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945273743&partnerID=MN8TOARS. 10.1039/c5tx00176e M. Matilde Marques; Karina Shimizu; André P. Ferreira; M. Teresa Duarte; Shrika G. Harjivan; J. L. Ferreira da Silva; Ferreira Da Silva, J.L.; et al. "Effect of substituents in the molecular and supramolecular architectures of 1-ferrocenyl-2-(aryl)thioethanones". CrystEngComm 17 16 (2015): 3089-3102. https://publons.com/publon/4501567/. 10.1039/C5CE00149H Harjivan, Shrika G.; Charneira, Catarina; Pereira, Sofia A.; Espadas, Guadalupe; Sabido, Eduard; Beland, Frederick A.; Matilde Marques, M.; Antunes, Alexandra M. M.. "Covalent histone modification by nevirapine: Potential association with non-AIDS defining cancers". Abstracts of Papers of the American Chemical Society 248 (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349167406286&KeyUID=WOS:000349167406286. Grilo, Nadia M.; Batalha, Vania L.; Lopes, Luisa V.; Matilde Marques, M.; Monteiro, Emilia C.; Antunes, Alexandra M. M.; Pereira, Sofia A.. "An animal model to explore efavirenz toxicokinetics and its relation to neurological phenotype". Toxicology Letters 229 (2014): S244-S244. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000341134000762&KeyUID=WOS:000341134000762. 10.1016/J.TOXLET.2014.06.813 Bandarra, S.; Fernandes, A.S.; Magro, I.; Guerreiro, P.S.; Pingarilho, M.; Churchwell, M.I.; Gil, O.M.; et al. "Erratum: Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells (Mutagenesis (2013) 28:6 (721-729))". Mutagenesis 29 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891367154&partnerID=MN8TOARS. 10.1093/mutage/get059 Marinho, A.T.; Godinho, A.L.A.; Novais, D.A.; Antunes, A.M.M.; Marques, M.M.; Ramos, T.; Dias, C.G.; et al. "Development and validation of an HPLC-UV method for quantifying nevirapine and its main phase i metabolites in human blood". Analytical Methods 6 5 (2014): 1575-1580. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894120111&partnerID=MN8TOARS. 10.1039/c3ay41911h Sofia Pereira; Emília Monteiro; Matilde Marques; Teresa Branco; Umbelina Caixas; Clara Dias; Aline Marinho; Alexandra Antunes. "Sex differences in apolipoprotein A1 and nevirapine-induced toxicity". Journal of the International AIDS Society (2014): https://publons.com/publon/18184289/. 10.7448/IAS.17.4.19575 Grilo, N.M.; Charneira, C.; Pereira, S.A.; Monteiro, E.C.; Marques, M.M.; Antunes, A.M.M.; Sofia A. Pereira; et al. "Bioactivation to an aldehyde metabolite-Possible role in the onset of toxicity induced by the anti-HIV drug abacavir". Toxicology Letters 224 3 (2014): 416-423. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890154590&partnerID=MN8TOARS. 10.1016/j.toxlet.2013.10.036 Sofia A. Pereira; Emília C. Monteiro; M. Matilde Marques; Alexandra M.M. Antunes; Inês Faustino; Umbelina Caixas; Aline T. Marinho; Clara G. Dias. "Thiol status in HIV-infected patients: The effect of nevirapine metabolism". Toxicology Letters (2014): https://publons.com/publon/11121375/. 10.1016/J.TOXLET.2014.06.352 E. C. Monteiro; S. G. Harjivan; A. M. M. Antunes; A. T. Marinho; S. A. Pereira; M. M. Marques; T. Branco; et al. "Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions". Journal of Antimicrobial Chemotherapy 69 2 (2014): 476-482. https://publons.com/publon/4396368/. 10.1093/JAC/DKT359 Alexandra M.M. Antunes; M. Matilde Marques; João L. Ferreira da Silva; Riccardo Wanke; Shrika G. Harjivan; Harjivan, S.G.; Wanke, R.; et al. "The phenolic metabolites of the anti-HIV drug efavirenz: Evidence for distinct reactivities upon oxidation with Frémy's salt". European Journal of Medicinal Chemistry 74 (2014): 7-11. https://publons.com/publon/4396381/. 10.1016/J.EJMECH.2013.12.022 Sofia A. Pereira; Joana P. Miranda; M. Matilde Marques; Emília C. Monteiro; Alexandra M.M. Antunes; Pedro F. Pinheiro; Clara G. Dias; Aline T. Marinho. "PON-1 activity as a protective player in nevirapine hepatotoxicity: Data comparison in 2D and 3D cell cultures". Toxicology Letters (2014): https://publons.com/publon/5063325/. 10.1016/J.TOXLET.2014.06.476 Matilde F. Castro; Aline T. Marinho; Joana P. Miranda; Sofia A. Pereira; M. Matilde Marques; Alexandra M.M. Antunes; Pedro F. Pinheiro. "Sex differences in hepatic and intestinal contributions for nevirapine biotransformation". Toxicology Letters (2014): https://publons.com/publon/5063382/. 10.1016/J.TOXLET.2014.06.803 Bandarra, S.; Fernandes, A.S.; Magro, I.; Guerreiro, P.S.; Pingarilho, M.; Churchwell, M.I.; Gil, O.M.; et al. "Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells". Mutagenesis 28 6 (2013): 721-729. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888626357&partnerID=MN8TOARS. 10.1093/mutage/get052 Beland, F.A.; Mellick, P.W.; Olson, G.R.; Mendoza, M.C.B.; Marques, M.M.; Doerge, D.R.. "Carcinogenicity of acrylamide in B6C3F1 mice and F344/N rats from a 2-year drinking water exposure". Food and Chemical Toxicology 51 1 (2013): 149-159. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867416800&partnerID=MN8TOARS. 10.1016/j.fct.2012.09.017 Marques, M. "Estrogen-induced systemic lupus erythematosus: Understanding the role of protein adducts in autoimmunity". Abstracts of Papers of the American Chemical Society (2013): https://publons.com/publon/11121338/. Alexandra M.M. Antunes; M. Matilde Marques; Sofia A. Pereira; Shrika G. Harjivan; Riccardo Wanke; Wanke, R.; Harjivan, S.G.; et al. "The role of competitive binding to human serum albumin on efavirenz–warfarin interaction: a nuclear magnetic resonance study". International Journal of Antimicrobial Agents 42 5 (2013): 443-446. https://publons.com/publon/4396362/. 10.1016/J.IJANTIMICAG.2013.06.023 M. Marques; Frederick Beland; M. Oliveira; Benjamin Wolf; Alexandra Antunes; Antunes, A.M.M.; Wolf, B.; et al. "2'-Deoxythymidine Adducts from the Anti-HIV Drug Nevirapine". Molecules 18 5 (2013): 4955-4971. https://publons.com/publon/4396363/. 10.3390/MOLECULES18054955 Grosse, Yann; Loomis, Dana; Lauby-Secretan, Beatrice; El Ghissassi, Fatiha; Bouvard, Veronique; Benbrahim-Tallaa, Lamia; Guha, Neela; et al. "Carcinogenicity of some drugs and herbal products". Lancet Oncology 14 9 (2013): 807-808. 10.1016/S1470-2045(13)70329-2 Miranda, J. P.; Pinheiro, P. F.; Marinho, A. T.; Harjivan, S. G.; Castro, M.; Pereira, S. A.; Antunes, A. M. M.; et al. "3D hepatocyte cultures: A useful tool in the study of Nevirapine bioactivation and toxicity". Toxicology Letters 221 (2013): S174-S174. https://publons.com/publon/5063334/. 10.1016/j.toxlet.2013.05.384 Grilo, N.M.; Antunes, A.M.M.; Caixas, U.; Marinho, A.T.; Charneira, C.; Conceição Oliveira, M.; Monteiro, E.C.; et al. "Monitoring abacavir bioactivation in humans: Screening for an aldehyde metabolite". Toxicology Letters 219 1 (2013): 59-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875885900&partnerID=MN8TOARS. 10.1016/j.toxlet.2013.02.021 Maria de F.C. Matos; M. Matilde Marques; Alexandra M.M. Antunes; Renata T. Perdomo; Danielle Bogo; Camila Santos Suniga Tozatti; James C. Burnett; et al. "Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity". Bioorganic & Medicinal Chemistry Letters 23 16 (2013): 4669-4673. https://publons.com/publon/1458128/. 10.1016/J.BMCL.2013.06.009 Frederick A. Beland; Igor P. Pogribny; M. Matilde Marques; Linda S. Von Tungeln; Igor Koturbash; William M. Witt; Gonçalo Gamboa da Costa; et al. "Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay". International Journal of Cancer 131 9 (2012): 2008-2015. https://publons.com/publon/11121300/. 10.1002/IJC.27493 Marques, M. "Binding of the anti-HIV drug Efavirenz to human serum albumin: A F-19-NMR study". Abstracts of Papers of the American Chemical Society (2012): https://publons.com/publon/11121303/. Marques, M. "Oxidation of phenolic nevirapine metabolites to a reactive quinone - a plausible pathway to toxicity". Abstracts of Papers of the American Chemical Society (2012): https://publons.com/publon/11121312/. Marques, M. "Hemoglobin adducts from the antiretroviral abacavir in HIV-infected patients as evidence of bioactivation". Abstracts of Papers of the American Chemical Society (2012): https://publons.com/publon/11121320/. Antunes, A.M.M.; Sidarus, M.; Novais, D.A.; Harjivan, S.G.; Santos, P.P.; Ferreira Da Silva, J.L.; Beland, F.A.; et al. "Oxidation of 2-hydroxynevirapine, a phenolic metabolite of the anti-HIV drug nevirapine: Evidence for an unusual pyridine ring contraction". Molecules 17 3 (2012): 2616-2627. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858980839&partnerID=MN8TOARS. 10.3390/molecules17032616 Charneira, C.; Grilo, N.M.; Pereira, S.A.; Godinho, A.L.A.; Monteiro, E.C.; Marques, M.M.; Antunes, A.M.M.. "N-terminal valine adduct from the anti-HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo". British Journal of Pharmacology 167 6 (2012): 1353-1361. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867773600&partnerID=MN8TOARS. 10.1111/j.1476-5381.2012.02079.x Pereira, S.A.; Wanke, R.; Marques, M.M.; Monteiro, E.C.; Antunes, A.M.M.. "Insights into the role of bioactivation mechanisms in the toxic events elicited by non-nucleoside reverse transcriptase inhibitors". Advances in Molecular Toxicology 6 (2012): 1-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865355478&partnerID=MN8TOARS. 10.1016/B978-0-444-59389-4.00001-X Caixas, U.; Antunes, A.M.M.; Marinho, A.T.; Godinho, A.L.A.; Grilo, N.M.; Marques, M.M.; Oliveira, M.C.; et al. "Evidence for nevirapine bioactivation in man: Searching for the first step in the mechanism of nevirapine toxicity". Toxicology 301 1-3 (2012): 33-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864807069&partnerID=MN8TOARS. 10.1016/j.tox.2012.06.013 Paula S. Branco; M. Matilde Marques; Alice S. Pereira; Filipa Siopa; Luísa Maria Ferreira; Siopa, F.; Pereira, A.S.; et al. "Synthesis of catecholamine conjugates with nitrogen-centered bionucleophiles". Bioorganic Chemistry 44 (2012): 19-24. https://publons.com/publon/10983496/. 10.1016/J.BIOORG.2012.05.002 Shrika G. Harjivan; Alexandra M. M. Antunes; M. Matilde Marques; David A. Novais; Riccardo Wanke; Wanke, R.; Novais, D.A.; et al. "Biomimetic oxidation of aromatic xenobiotics: synthesis of the phenolic metabolites from the anti-HIV drug efavirenz". Organic & Biomolecular Chemistry 10 23 (2012): 4554-4561. https://publons.com/publon/4396393/. 10.1039/C2OB25212K M. Teresa Duarte; André P. Ferreira; J. L. Ferreira da Silva; M. Fátima M. da Piedade; Shrika G. Harjivan; M. Matilde Marques; Ferreira Da Silva, J.L.; et al. "Effect of C–H…X interactions (X = O, S, p) in the supramolecular arrangements of 3-ferrocenyl-methoxybenzo[b]thiophene isomers". CrystEngComm 13 5 (2011): 1638-1645. https://publons.com/publon/11121356/. 10.1039/C0CE00434K Charneira, C.; Godinho, A.L.A.; Oliveira, M.C.; Pereira, S.A.; Monteiro, E.C.; Marques, M.M.; Antunes, A.M.M.. "Reactive aldehyde metabolites from the anti-HIV drug abacavir: Amino acid adducts as possible factors in abacavir toxicity". Chemical Research in Toxicology 24 12 (2011): 2129-2141. http://www.scopus.com/inward/record.url?eid=2-s2.0-84055218870&partnerID=MN8TOARS. 10.1021/tx200337b Antunes, Alexandra M. M.; Novais, David A.; Ferreira da Silva, J. L.; Santos, Pedro P.; Conceição Oliveira, M.; Beland, Frederick A.; Matilde Marques, M.. "Synthesis and oxidation of 2-hydroxynevirapine, a metabolite of the HIV reverse transcriptase inhibitor nevirapine". Organic & Biomolecular Chemistry 9 22 (2011): 7822. http://dx.doi.org/10.1039/c1ob06052j. Published • 10.1039/c1ob06052j Fu, Peter P.; Chou, Ming W.; Churchwell, Mona; Wang, Yuping; Zhao, Yuewei; Xia, Qingsu; Gamboa da Costa, Gonc¸alo; et al. "High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Pyrrolizidine Alkaloid-Derived DNA Adductsin Vitroandin Vivo". Chemical Research in Toxicology 23 3 (2010): 637-652. http://dx.doi.org/10.1021/tx900402x. 10.1021/tx900402x André, V.; Marques, M.M.; Da Piedade, M.F.M.; Duarte, M.T.; M. Matilde Marques; M. Teresa Duarte; M.F. Minas da Piedade; Vânia André. "An ester derivative of the drug gabapentin: PH dependent crystal stability". Journal of Molecular Structure 973 1-3 (2010): 173-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954216808&partnerID=MN8TOARS. 10.1016/j.molstruc.2010.03.067 Antunes, A.M.M.; Godinho, A.L.A.; Martins, I.L.; Oliveira, M.C.; Gomes, R.A.; Coelho, A.V.; Beland, F.A.; Marques, M.M.. "Protein adducts as prospective biomarkers of nevirapine toxicity". Chemical Research in Toxicology 23 11 (2010): 1714-1725. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649281814&partnerID=MN8TOARS. 10.1021/tx100186t Antunes, A.M.M.; Godinho, A.L.A.; Martins, I.L.; Justino, G.C.; Beland, F.A.; Marques, M.M.. "Amino acid adduct formation by the nevirapine metabolite, 12-Hydroxynevirapine- A Possible Factor in Nevirapine Toxicity". Chemical Research in Toxicology 23 5 (2010): 888-899. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952359731&partnerID=MN8TOARS. 10.1021/tx900443z Von Tungeln, L.S.; Churchwell, M.I.; Doerge, D.R.; Shaddock, J.G.; McGarrity, L.J.; Heflich, R.H.; Da Costa, G.G.; et al. "DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide". International Journal of Cancer 124 9 (2009): 2006-2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-63449122295&partnerID=MN8TOARS. 10.1002/ijc.24165 Ferreira, A.P.; Ferreira Da Silva, J.L.; Duarte, M.T.; Fátima Minas Da Piedade, M.; Paula Robalo, M.; Harjivan, S.G.; Marzano, C.; Gandin, V.; Matilde Marques, M.. "Synthesis and characterization of new organometallic benzo[b]thiophene derivatives with potential antitumor properties". Organometallics 28 18 (2009): 5412-5423. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349326103&partnerID=MN8TOARS. 10.1021/om9003835 José A. L. da Silva; M. Matilde Marques; Ana F. Amaral; Amaral, A.F.; Marques, M.M.; Da Silva, J.A.L.; Fraústo Da Silva, J.J.R.. "Interactions of d-ribose with polyatomic anions, and alkaline and alkaline-earth cations: possible clues to environmental synthesis conditions in the pre-RNA world". New Journal of Chemistry 32 11 (2008): 2043-2049. https://publons.com/publon/11121295/. 10.1039/B809636H Antunes, A.M.M.; Duarte, M.P.; Santos, P.P.; Da Costa, G.G.; Heinze, T.M.; Beland, F.A.; Marques, M.M.. "Synthesis and characterization of DNA adducts from the HIV reverse transcriptase inhibitor nevirapine". Chemical Research in Toxicology 21 7 (2008): 1443-1456. http://www.scopus.com/inward/record.url?eid=2-s2.0-49049089966&partnerID=MN8TOARS. 10.1021/tx8000972 J. F. Gaspar; J. Rueff; D. R. Doerge; M. I. Churchwell; F. A. Beland; M. M. Marques; G. Gamboa da Costa; et al. "Cytogenetic damage induced by acrylamide and glycidamide in mammalian cells: Correlation with specific glycidamide-DNA adducts". Toxicological Sciences 95 2 (2007): 383-390. https://publons.com/publon/8733556/. 10.1093/TOXSCI/KFL155 Gamboa da Costa, G.; Marques, M.M.; Fu, X.; Churchwell, M.I.; Wang, Y.-P.; Doerge, D.R.; Beland, F.A.; et al. "Effect of N,N-didesmethyltamoxifen upon DNA adduct formation by tamoxifen and a-hydroxytamoxifen". Cancer Letters 257 2 (2007): 191-198. http://www.scopus.com/inward/record.url?eid=2-s2.0-35048822885&partnerID=MN8TOARS. 10.1016/j.canlet.2007.07.014 Da Costa, G.G.; Pereira, P.C.; Churchwell, M.I.; Beland, F.A.; Marques, M.M.. "DNA adduct formation in the livers of female Sprague-Dawley rats treated with toremifene or a-hydroxytoremifene". Chemical Research in Toxicology 20 2 (2007): 300-310. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947160165&partnerID=MN8TOARS. 10.1021/tx600275d David H. Phillips; Gonçalo Gamboa da Costa; M. Matilde Marques; Frederick A. Beland. "Tamoxifen-DNA Adduct Formation in Human Endometrium". Chemical Research in Toxicology (2005): https://publons.com/publon/11121333/. 10.1021/TX050255W Vidal, S.T.M.; Correia, M.J.N.; Marques, M.M.; Ismael, M.R.; Reis, M.T.A.. "Studies on the use of ionic liquids as potential extractants of phenolic compounds and metal ions". Separation Science and Technology 39 9 (2004): 2155-2169. http://www.scopus.com/inward/record.url?eid=2-s2.0-3843099317&partnerID=MN8TOARS. 10.1081/SS-120039311 Alan Hewer; Mona I Churchwell; Frederick A Beland; Gonçalo Gamboa da Costa; M Matilde Marques; David H Phillips; Beland, F.A.; et al. "Analysis of tamoxifen–DNA adducts in endometrial explants by MS and 32 P-postlabeling". Biochemical and Biophysical Research Communications 320 2 (2004): 297-302. https://publons.com/publon/11121272/. 10.1016/J.BBRC.2004.05.168 Beland, F.A.; Churchwell, M.I.; Doerge, D.R.; Parkin, D.R.; Malejka-Giganti, D.; Hewer, A.; Phillips, D.H.; et al. "Electrospray ionization-tandem mass spectrometry and 32P-postlabeling analyses of tamoxifen-DNA adducts in humans". Journal of the National Cancer Institute 96 14 (2004): 1099-1104. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444274918&partnerID=MN8TOARS. Fonseca, T.; Gigante, B.; Marques, M.M.; Gilchrist, T.L.; De Clercq, E.; Erik De Clercq; Thomas L. Gilchrist; et al. "Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid". Bioorganic and Medicinal Chemistry 12 1 (2004): 103-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346671323&partnerID=MN8TOARS. 10.1016/j.bmc.2003.10.013 Roberts, D.W.; Doerge, D.R.; Churchwell, M.I.; Da Costa, G.G.; Marques, M.M.; Tolleson, W.H.. "Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover)". Journal of Agricultural and Food Chemistry 52 21 (2004): 6623-6632. http://www.scopus.com/inward/record.url?eid=2-s2.0-6344277277&partnerID=MN8TOARS. 10.1021/jf049418x Da Costa, G.G.; Churchwell, M.I.; Hamilton, L.P.; Von Tungeln, L.S.; Beland, F.A.; Marques, M.M.; Doerge, D.R.; et al. "DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice". Chemical Research in Toxicology 16 10 (2003): 1328-1337. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142200904&partnerID=MN8TOARS. 10.1021/tx034108e Da Costa, G.G.; Marques, M.M.; Beland, F.A.; Freeman, J.P.; Churchwell, M.I.; Doerge, D.R.. "Quantification of tamoxifen DNA adducts using on-line sample preparation and HPLC-electrospray ionization tandem mass spectrometry". Chemical Research in Toxicology 16 3 (2003): 357-366. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037350190&partnerID=MN8TOARS. 10.1021/tx020090g Gamboa da Costa, G.; Marques, M.M.; Freeman, J.P.; Beland, F.A.. "Synthesis and investigation of a-hydroxy-N,N-didesmethyltamoxifen as a proximate carcinogen in the metabolic activation of tamoxifen". Chemical Research in Toxicology 16 9 (2003): 1090-1098. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141625019&partnerID=MN8TOARS. 10.1021/tx030010o Schild, L.J.; Divi, R.L.; Beland, F.A.; Churchwell, M.I.; Doerge, D.R.; Da Costa, G.G.; Marques, M.M.; Poirier, M.C.. "Formation of tamoxifen-DNA adducts in multiple organs of adult female cynomolgus monkeys dosed with tamoxifen for 30 days". Cancer Research 63 18 (2003): 5999-6003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141507957&partnerID=MN8TOARS. Linge Li; Frederick A. Beland; Luísa L. Gonçalves; M. Matilde Marques; Alexandra M. Antunes; Paula S. Branco; M. Paul Chiarelli; et al. "Differentiation of isomeric C8-substituted alkylaniline adducts of guanine by electrospray ionization and tandem quadrupole ion trap mass spectrometry". Journal of the American Society for Mass Spectrometry 14 12 (2003): 1488-1492. https://publons.com/publon/4396394/. 10.1016/J.JASMS.2003.08.009 Chen, T.; Da Costa, G.G.; Marques, M.M.; Shelton, S.D.; Beland, F.A.; Manjanatha, M.G.. "Mutations induced by a-hydroxytamoxifen in the lacI and cII genes of big blue transgenic rats". Carcinogenesis 23 10 (2002): 1751-1757. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036798839&partnerID=MN8TOARS. Matilde Marques, M.; Gamboa Da Costa, G.; Blankenship, L.R.; Culp, S.J.; Beland, F.A.. "The effect of deuterium and fluorine substitution upon the mutagenicity of N-hydroxy-2,6-dimethylaniline". Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 506-507 (2002): 41-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037201540&partnerID=MN8TOARS. 10.1016/S0027-5107(02)00150-1 Howard, P.C.; Couch, L.H.; Patton, R.E.; Eppley, R.M.; Doerge, D.R.; Churchwell, M.I.; Marques, M.M.; Okerberg, C.V.. "Comparison of the toxicity of several fumonisin derivatives in a 28-day feeding study with female B6C3F1 mice". Toxicology and Applied Pharmacology 185 3 (2002): 153-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036935316&partnerID=MN8TOARS. 10.1006/taap.2002.9529 Fang, J.-L.; Beland, F.A.; Doerge, D.R.; Wiener, D.; Guillemette, C.; Marques, M.M.; Lazarus, P.. "Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes". Cancer Research 62 7 (2002): 1978-1986. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036532140&partnerID=MN8TOARS. Dean W. Roberts; Daniel R. Doerge; M. Matilde Marques; Mona I. Churchwell; William H. Tolleson; Tolleson, W.H.; Doerge, D.R.; et al. "Metabolism of Biochanin A and Formononetin by Human Liver Microsomes in Vitro". Journal of Agricultural and Food Chemistry 50 17 (2002): 4783-4790. https://publons.com/publon/11121275/. 10.1021/JF025549R Gamboa da Costa, G.; Manjanatha, M.G.; Matilde Marques, M.; Beland, F.A.. "Induction of lacI mutations in Big Blue rats treated with tamoxifen and a-hydroxytamoxifen". Cancer Letters 176 1 (2002): 37-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037039714&partnerID=MN8TOARS. 10.1016/S0304-3835(01)00741-8 Ritter, C.L.; Culp, S.J.; Freeman, J.P.; Marques, M.M.; Beland, F.A.; Malejka-Giganti, D.; Frederick A. Beland; et al. "DNA adducts from nitroreduction of 2,7-dinitrofluorene, a mammary gland carcinogen, catalyzed by rat liver or mammary gland cytosol". Chemical Research in Toxicology 15 4 (2002): 536-544. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036223760&partnerID=MN8TOARS. 10.1021/tx010172p Gonçalves, L.L.; Beland, F.A.; Marques, M.M.. "Synthesis, characterization, and comparative 32P-postlabeling efficiencies of 2,6-dimethylaniline-DNA adducts". Chemical Research in Toxicology 14 2 (2001): 165-174. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035101458&partnerID=MN8TOARS. 10.1021/tx0002031 Gamboa Da Costa, G.; McDaniel-Hamilton, L.P.; Heflich, R.H.; Marques, M.M.; Beland, F.A.. "DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives". Carcinogenesis 22 8 (2001): 1307-1315. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034903983&partnerID=MN8TOARS. Gamboa Da Costa, G.; Hamilton, L.P.; Beland, F.A.; Marques, M.M.. "Characterization of the major DNA adduct formed by a-hydroxy-N- desmethyltamoxifen in vitro and in vivo". Chemical Research in Toxicology 13 3 (2000): 200-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034122954&partnerID=MN8TOARS. 10.1021/tx990187b Santos, M.A.; Afonso, A.; Marques, M.M.; Wilcox, C.. "Molecular Recognition of Acetylaminofluorene- and Aminofluorene-modified Guanosine". Supramolecular Chemistry 11 3 (2000): 201-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034395984&partnerID=MN8TOARS. Doerge, D.R.; Churchwell, M.I.; Marques, M.M.; Beland, F.A.; Beland FA; Marques MM; Churchwell MI; D. R. Doerge. "Quantitative analysis of 4-aminobiphenyl-C8-deoxyguanosyl DNA adducts produced in vitro and in vivo using HPLC-ES-MS". Carcinogenesis 20 6 (1999): 1055-1061. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032984919&partnerID=MN8TOARS. 10.1093/carcin/20.6.1055 Beland, F.A.; Doerge, D.R.; Churchwell, M.I.; Poirier, M.C.; Schoket, B.; Marques, M.M.; Mona I. Churchwell; et al. "Synthesis, characterization, and quantitation of a 4-aminobiphenyl-DNA adduct standard". Chemical Research in Toxicology 12 1 (1999): 68-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032943363&partnerID=MN8TOARS. 10.1021/tx980172y M. Matilde Marques; Paula S. Branco; Sundaresan Prabhakar; Ana M. Lobo; M. Paul Chiarelli; Alexandra M. M. Antunes; Branco, P.S.; et al. "New syntheses of DNA adducts from methylated anilines present in tobacco smoke". Chemical Research in Toxicology 12 12 (1999): 1223-1233. https://publons.com/publon/4396395/. 10.1021/TX9901229 Beland, F.A.; McDaniel, L.P.; Marques, M.M.. "Comparison of the DNA adducts formed by tamoxifen and 4-hydroxytamoxifen in vivo". Carcinogenesis 20 3 (1999): 471-477. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033065364&partnerID=MN8TOARS. Mourato, L.L.G.; Beland, F.A.; Marques, M.M.. "32P-postlabeling of N-(deoxyguanosin-8-yl)arylamine adducts: A comparative study of labeling efficiencies". Chemical Research in Toxicology 12 7 (1999): 661-669. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032588184&partnerID=MN8TOARS. 10.1021/tx990038t Howard, P.C.; Churchwell, M.I.; Couch, L.H.; Marques, M.M.; Doerge, D.R.. "Formation of N-(Carboxymethyl)fumonisin B1, Following the Reaction of Fumonisin B1 with Reducing Sugars". Journal of Agricultural and Food Chemistry 46 9 (1998): 3546-3557. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001360367&partnerID=MN8TOARS. Marques, M.M.; Mourato, L.L.G.; Amorim, M.T.; Santos, M.A.; Melchior Jr., W.B.; Beland, F.A.. "Effect of substitution site upon the oxidation potentials of alkylanilines, the mutagenicities of N-hydroxyalkylanilines, and the conformations of alkylaniline-DNA adducts". Chemical Research in Toxicology 10 11 (1997): 1266-1274. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030819637&partnerID=MN8TOARS. 10.1021/tx970104w Beland, F.A.; Melchior Jr., W.B.; Mourato, L.L.G.; Santos, M.A.; Marques, M.M.. "Arylamine-DNA adduct conformation in relation to mutagenesis". Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 376 1-2 (1997): 13-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030949281&partnerID=MN8TOARS. 10.1016/S0027-5107(97)00020-1 Beland FA; M. Marques; Marques, M.M.; Beland, F.A.. "Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide". Carcinogenesis 18 10 (1997): 1949-1954. https://publons.com/publon/11121288/. 10.1093/CARCIN/18.10.1949 Marques, M.M.; Mourato, L.L.G.; Santos, M.A.; Beland, F.A.. "Synthesis, characterization, and conformational analysis of DNA adducts from methylated anilines present in tobacco smoke". Chemical Research in Toxicology 9 1 (1996): 99-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030034422&partnerID=MN8TOARS. 10.1021/tx950044z BELAND, FA; DREW, MG; ESTEVES, MA; FERREIRA, T; MARQUES, MM; SANTOS, MA. "MOLECULAR RECOGNITION OF GUANOSINE AND 2-ACETYLAMINOFLUORENE-MODIFIED GUANOSINE - A COMPARATIVE-STUDY". Supramolecular Chemistry 5 4 (1995): 243-253. 10.1080/10610279508233951 Dias, A.R.; Duarte, M.T.; Galvão, A.M.; Garcia, M.H.; Marques, M.M.; Salema, M.S.; Masi, D.; Mealli, C.. "Uracil and thiouracil complexes of dicyclopentadienyl molybdenum and tungsten: Preparation and electrochemistry. The structures of [M(¿5-C5H5)2(2-SN 2OC4H3)][PF6], [M(¿5-C5H5)2{2-S(CH 3)N2OC4H2}][PF6],...". Polyhedron 14 5 (1995): 675-685. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038580753&partnerID=MN8TOARS. 10.1016/0277-5387(94)00288-P Melchior Jr., W.B.; Marques, M.M.; Beland, F.A.. "Mutations induced by aromatic amine DNA adducts in pBR322". Carcinogenesis 15 5 (1994): 889-899. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027975141&partnerID=MN8TOARS. 10.1093/carcin/15.5.889 Cho, B.P.; Beland, F.A.; Matilde Marques, M.. "NMR structural studies of a 15-mer DNA duplex from a ras protooncogene modified with the carcinogen 2-aminofluorene: conformational heterogeneity". Biochemistry 33 6 (1994): 1373-1384. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028323638&partnerID=MN8TOARS. BELAND, FA; CHO, BP; MARQUES, MM. "ONE-DIMENSIONAL MULTIPLE-QUANTUM FILTRATION H-1-NMR SPECTRA OF A 15-MER DNA DUPLEX MODIFIED BY THE CARCINOGEN 4-AMINOBIPHENYL". Magnetic Resonance in Chemistry 31 11 (1993): 1008-1010. Published • 10.1002/mrc.1260311110 Cho, B.P.; Beland, F.A.; Marques, M.M.. "NMR structural studies of a 15-mer DNA sequence from a ras protooncogene, modified at the first base of codon 61 with the carcinogen 4-aminobiphenyl". Biochemistry 31 40 (1992): 9587-9602. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026795019&partnerID=MN8TOARS. Marques, M.M.; Beland, F.A.. "Synthesis, characterization, and solution properties of ras sequences modified by arylamine carcinogens at the first base of codon". Chemical Research in Toxicology 3 6 (1990): 559-565. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025253880&partnerID=MN8TOARS. Poirier MC; Smith BA; Melchior WB Jr; Beland FA; Fullerton NF; M. Matilde Marques. "DNA ADDUCT FORMATION IN RELATION TO TUMORIGENESIS IN MICE CONTINUOUSLY ADMINISTERED 4-AMINOBIPHENYL". Mutation and the Environment, Part A (1990): https://publons.com/publon/19002049/. Lobo, A.M.; Marques, M.M.; Prabhakar, S.; Rzepa, H.S.. "Tetrahedral intermediates formed by nitrogen and oxygen attack of aromatic hydroxylamines on acetyl cyanide". Journal of Organic Chemistry 52 13 (1987): 2925-2927. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000195484&partnerID=MN8TOARS. Published Rzepa, H.S.; Lobo, A.M.; Matilde Marques, M.; Prabhakar, S.. "Characterizing a tetrahedral intermediate in an acyl transfer reaction: An undergraduate 1 H NMR demonstration". Journrl of Chemical Education 64 8 (1987): 725-726. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845281927&partnerID=MN8TOARS. Published PRABHAKAR, S.; LOBO, A. M.; MARQUES, M. M.. "A New Synthesis of the Amaryllidaceae Alkaloid Hippadine". Journal of Chemical Research (1987): 167-167. http://dx.doi.org/10.1002/chin.198740351. Published • 10.1002/chin.198740351 PRABHAKAR, S.; LOBO, A. M.; MARQUES, M. M.; TAVARES, M. R.. "A Synthesis of the Alkaloid Ismine". Chemischer Informationsdienst 17 15 (1986): http://dx.doi.org/10.1002/chin.198615355. 10.1002/chin.198615355 Lobo, A.M.; Marques, M.M.; Prabhakar, S.; Rzepa, H.S.. "Tetrahedral intermediates formed during acyl transfer. Reactions of acetyl cyanide". Journal of the Chemical Society, Chemical Communications 16 (1985): 1113-1115. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049105414&partnerID=MN8TOARS. Published LOBO, AM; MARQUES, MM; PRABHAKAR, S. "REACTIONS BETWEEN HYDROXYLAMINES AND AROYL CYANIDES". Tetrahedron Letters 23 13 (1982): 1391-1394. Published • 10.1016/S0040-4039(00)87114-2
Preprint	Rosado, Pedro; Marques, M. Matilde; Justino, Goncalo. "Targeting MRSA penicillin-binding protein 2a: structural insights, allosteric mechanisms, and the potential of adjuvant inhibitors". 2025. https://doi.org/10.22541/au.173840407.75774545/v1. 10.22541/au.173840407.75774545/v1 Justino, Gonçalo; Pinheiro, Pedro; Marques, M. Matilde; Miranda, Joana. "An engineered small ligand activates NK cells and triggers their cytolytic activity". 2024. https://doi.org/10.21203/rs.3.rs-5290318/v1. 10.21203/rs.3.rs-5290318/v1 Marques, Cátia; Marques, M. Matilde; Justino, Goncalo. "The elusive pathways behind montelukast's repurposing for Alzheimer's disease". 2022. https://doi.org/10.22541/au.166678108.88018118/v1. 10.22541/au.166678108.88018118/v1

Other

Other output

Bitumens and bitumen emissions, and some heterocyclic polycyclic aromatic hydrocarbons. 2011. Lauby-Secretan, B; Baan, R; Grosse, Y; El Ghissassi, F; Bouvard, V; Benbrahim-Talla, L; Guha, N; et al.
10.1016/S1470-2045(11)70359-X
A review of human carcinogens—Part A: pharmaceuticals. 2009. Grosse, Y; Baan, R; Straif, K; Secretan, B; El Ghissassi, F.; Bouvard, V; Benbrahim-Tallaa, L; et al.
10.1016/S1470-2045(08)70286-9
Carcinogenicity of alcoholic beverages. 2007. Baan, R; Straif, K; Grosse, Y; Secretan, B; El Ghissassi, F; Bouvard, V; Altieri, A; Cogliano, V; the WHO International Agency for Research on Cancer Monograph Working Group.
10.1016/S1470-2045(07)70099-2
Carcinogenicity of Polycyclic Aromatic Hydrocarbons. 2005. Straif, K; Baan, R; Grosse, Y; Secretan, B; El Ghissassi, F; Cogliano, V; the WHO International Agency for Research on Cancer Monograph Working Group. http://dx.doi.org/10.1016/S1470-2045(05)70458-7.
10.1016/S1470-2045(05)70458-7

Activities

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2021 - 2025	Overcoming ß-lactam antibiotics resistance in methicillinresistant Staphylococcus aureus – Targeting penicillin-binding protein 2a Co-supervisor	Chemistry (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2023 - 2023	Synthesis and biological evaluation of new molecular entities with the potential to overcome ß-lactam antibiotics resistance in methicillin-resistant Staphyloccocus aureus (MRSA) Co-supervisor	Ciência e Engenharia Moleculares (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 - 2022/12	Toxicological and mechanistic evaluation behind Montelukast repurposing: metabolomic and proteomic approaches Supervisor	Química (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022 - 2022	Targeting the “undruggable”: a combinatorial platform for the discovery of peptidomimetic covalent inhibitors of protein-protein interactions Co-supervisor	Engenharia Biológica (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/02/01 - 2021/10/31	The natural killer cell activation compound 815A: solubility, stability, and injectable formulations, Engenharia Farmacêutica, IST (concluído 2021 Co-supervisor	Pharmaceutical Engineering (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2020	An epigenetic approach to anticancer therapy: Design, synthesis and biological evaluation of novel EZH2 inhibitors Supervisor	Química (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2020	Targeting glucose metabolism for cancer treatment: dual inhibition of hexokinase II Supervisor	Química (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2020	Triggering a specific immune response against cancer – a strategy for primary and metastatic tumor treatment Supervisor	Química (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2018	Chemical Proteomics: mass spectrometry-based label-free quantitative approach in cell systems Co-supervisor	Engenharia Biológica (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2018	Development of a bacterial model for the production of functional human drug metabolizing enzymes Co-supervisor	Biotecnologia (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2018	Síntese e caracterização de biomarcadores da etil vinil cetona Supervisor	Biotecnologia (Degree) Instituto Politécnico de Setúbal Escola Superior de Tecnologia do Barreiro, Portugal
2016 - 2018	Synthesis and assessment of novel thiazolopyrimidine derivatives with prospective biological activity Co-supervisor	Chemistry (PhD) South Valley University Faculty of Science, Egypt
2011 - 2018	Desenvolvimento de novos biomarcadores de toxicidade dos fármacos carbamazepina e oxcarbazepina Co-supervisor	Química (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017	Development of separation methods for Botulinum neurotoxins, using a statistical modelling-based approach Co-supervisor	Engenharia Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017	Síntese e caracterização de biomarcadores da metil vinil cetona Supervisor	Biotecnologia (Degree) Instituto Politécnico de Setúbal Escola Superior de Tecnologia do Barreiro, Portugal
2012 - 2017	CHEMICAL MODIFICATION OF BIONUCLEOPHILES BY NNRTI METABOLITES: A MOLECULAR BASIS FOR NON-AIDS DEFINING CANCERS AND OTHER TOXIC EFFECTS? Supervisor	Química (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2011 - 2017	Estratégias in vitro e in vivo para o estudo da bioativação do fármaco anti-HIV etravirina Co-supervisor	Química (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016	Estudos de Reactividade de Metabolitos do Fármaco Antiplaquetário Clopidogrel Co-supervisor	Engenharia Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2015	Proteção de fármacos oxidáveis: formulação e processo Co-supervisor	Engenharia Farmacêutica (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2015	Garantia e Controlo da Qualidade na Validação de Processo de fabrico de Pó para Suspensão Oral Extemporânea Co-supervisor	Engenharia Farmacêutica (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2015	Estudos de Estabilidade de Formas Farmacêuticas HPLC e controlo microbiológico Co-supervisor	Engenharia Farmacêutica (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2015	Development of a method of extraction and quantification of polycyclic aromatic hydrocarbons from a bituminous matrix Co-supervisor	Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2015	Activação de aloe emodina a espécies electrófilas. Potencial relação com a carcinogenicidade de Aloe barbadensis Miller Supervisor	Bioquímica (Degree) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2012	Síntese estereoselectiva de hidroxi ciclopentenaminas e ciclohexenaminas a partir das respectivas cicloenonas Co-supervisor	Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 - 2012	A first total synthesis of (L)-erythro-ceramide C6 from natural (L)-serine Co-supervisor	Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 - 2012	New approach for synthesis of biologically active chiral 5-substituted tetrazoles Co-supervisor	Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2011 - 2011	Estudo do sistema catalítico de oxidação com ácido p-toluenosulfónico/peróxido de hidrogénio aplicado ao ciclohexadieno e ao dibenzotiofeno Co-supervisor	Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2011 - 2011	Extracção selectiva do ácido labdanólico de extracto natural utilizando polímeros molecularmente impressos Co-supervisor	Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2011	Modificação de proteínas e DNA por quinonas derivadas de catecolaminas Co-supervisor	Química (PhD) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008 - 2011	Síntese e avaliação biológica de análogos da combrestatina A-4 com os átomos de enxofre e selénio como grupos espaçadores Co-supervisor	Química (PhD) Universidade Federal de Mato Grosso do Sul, Brazil
2010 - 2010	Synthesis of chemically modified oligonucleotides: An approach to orthogonal modification Co-supervisor	Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2009 - 2009	Synthesis and characterization of deoxythymidine adducts from the HIV reverse transcriptase inhibitor nevirapine Co-supervisor	Química (Scientific initiation) Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2009	Análise de adutos de aminoácidos com o fármaco nevirapina por LC-ESI-MS Co-supervisor	Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2008	Síntese de um peptidoglicano bacteriano reconhecido pelo sistema imunitário Co-supervisor	Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2008	Synthesis of organometallic compounds with potencial therapeutic properties Supervisor	Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2008	Design, synthesis and testing of new Ras inhibitors: nucleotide exchange inhibition as a novel approach Co-supervisor	Engenharia Biológica (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2007 - 2008	Os ácidos hidrocinâmicos como precursores de fenóis voláteis em vinhos tintos Co-supervisor	Engenharia Química - Química Aplicada (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2007 - 2007	New studies on ionic liquids Co-supervisor	Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2007 - 2007	Validação de métodos de detecção de drogas de abuso por GC/MS. Avaliação de Robustez Co-supervisor	Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2007 - 2007	Boro: um elemento fundamental nos primórdios da vida na terra? Co-supervisor	Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2007 - 2007	Estudos de oxidação da 2-hidroxi-nevirapina, metabolito do fármaco anti-HIV nevirapina Supervisor	Química (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2005 - 2005	Desenvolvimento e validação de um método de quantificação de opiáceos em urina humana por HPLC-UV/DAD Co-supervisor	Química (Degree) Universidade de Lisboa Instituto Superior Técnico, Portugal
2004 - 2004	Separação e identificação de polissacáridos presentes em aglutinantes e encolagens por HPLC-PDA Co-supervisor	Engenharia Química (Other) Universidade de Lisboa Instituto Superior Técnico, Portugal
2004 - 2004	Estudos sobre o HES no âmbito do controlo antidopagem Co-supervisor	Química (Other) Universidade de Lisboa Instituto Superior Técnico, Portugal
2001 - 2002	Síntese de líquidos iónicos e avaliação do seu potencial em processos de extracção líquido-líquido Co-supervisor	Universidade de Lisboa Instituto Superior Técnico, Portugal
1998 - 2002	Interacção do ADN com Metabolitos do Tamoxifen - Síntese, Quantificação e Avaliação Mutagénica de Adutos Covalentes Supervisor	Química (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2000 - 2001	Síntese de compostos do tipo ß-halo- a-hidroxitamoxifen Supervisor	Universidade de Lisboa Instituto Superior Técnico, Portugal
1998 - 2001	Synthesis of Heterocycles Derived from Dehydroabietic Acid Co-supervisor	Química (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
1995 - 2000	Adutos ADN-monoarilamina: Síntese, Caracterização e Estudos de Pós-marcação com Fósforo-32 Supervisor	Química (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
1997 - 1998	Síntese e reactividade de metabolitos do tamoxifen Supervisor	Química Orgânica e Tecnológica (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1992 - 1994	Estudos de modificação química da 2'-desoxiguanosina com aminas aromáticas Supervisor	Engenharia Química - Química Aplicada (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
1991 - 1992	Síntese de uracilos metilados Co-supervisor	Engenharia Química (Other) Universidade de Lisboa Instituto Superior Técnico, Portugal

Association member

	Society Organization name	Role
2016 - Current	Royal Society of Chemistry
2011 - Current	Sociedade Portuguesa de Química
1998 - Current	American Chemical Society
1990 - Current	American Association for Cancer Research

Committee member

	Activity description Role	Institution / Organization
2020 - Current	IUPAC Subcommittee on Toxicology and Risk Assessment Member	International Union of Pure and Applied Chemistry, United States
2019 - Current	ESF College of Expert Reviewers	European Science Foundation, France
2021/01 - 2023/12/31	Executive Committee, Division of Chemical Toxicology, American Chemical Society (Elected)
2023/06/06 - 2023/06/13	Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 134: Aspartame, Methyleugenol, and Isoeugenol Chair, Mechanisms subgroup Member	International Agency for Research on Cancer Group IARC Monographs, France
2020/10/29 - 2020/11/13	Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 128: Acrolein, Crotonaldehyde, and Arecoline (Chair) Other	International Agency for Research on Cancer, France
2017 - 2020	Division of Medicinal Chemistry SPQ President / Vice-president	Sociedade Portuguesa de Química, Portugal
2017 - 2020	Council member, EFMC Member	European Federation for Medicinal Chemistry, Belgium
2019 - 2019	Advisory Group to Recommend Priorities for the IARC Monographs during 2020–2024 (Chair) Coordinator	International Agency for Research on Cancer, France
2018 - 2018	Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 122 Chair, Mechanisms subgroup) Member	International Agency for Research on Cancer, France
2015 - 2017	Alternative Councilor (elected), Division of Chemical Toxicology Other	American Chemical Society, United States
2016 - 2016	Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 115 Member	International Agency for Research on Cancer, France
2013 - 2013	Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 108 (Chair, Mechanisms Subgroup) Member	International Agency for Research on Cancer, France
2011 - 2011	Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 103 Member	International Agency for Research on Cancer, France
2008 - 2008	Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 100A (co-chair, Mechanisms subgroup) Member	International Agency for Research on Cancer, France
2008 - 2008	Working Group, Acrylamide carcinogenicity new evidence in relation to dietary exposure Member	European Food Safety Authority, Italy
2007 - 2007	Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 96 Member	International Agency for Research on Cancer, France
2005 - 2005	Working Group, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 92 Member	International Agency for Research on Cancer, France

Consulting

	Activity description	Institution / Organization
2008 - Current	Technical Arbitrary Court Assistant in multiple Intellectual Property Litigations on Pharmaceutical Products

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2021/01 - 2021	Grant Application Reviewer, New York University Abu Dhabi Evaluator	New York University - Abu Dhabi Campus, United Arab Emirates

Journal scientific committee

	Journal title (ISSN)	Publisher
2020 - Current	Pharmaceuticals	MDPI
2008 - 2022	Chemical Research in Toxicology	American Chemical Society
2011 - 2014	ISRN Toxicology (2090-6196)	Hindawi (International Scholarly Research Network)
2001 - 2003	Chemical Research in Toxicology	American Chemical Society

Other jury / evaluation

	Activity description	Institution / Organization
2021 - Current	Young Investigator Award jury, Chemical Research in Toxicology, American Chemical Society
1988 - Current	Reviewer for ca. 60 scientific journals listed in the Web of Knowledge database
2025 - 2025	FWO Excellence Prize application reviewer (Joseph Maisin Prize for clinical biomedical sciences), Belgium	Fonds Wetenschappelijk Onderzoek Vlaanderen, Belgium
2024 - 2024	Grant application reviewer, PhD fellowships, FCT
2022 - 2024	Coordinator, Final Report Evaluation, Scientific Projects - Chemistry, 2019-2023, FCT	Fundação para a Ciência e a Tecnologia, Portugal
2023/09 - 2023/10	Grant application reviewer, National Science Centre Poland, OPUS-25	Narodowe Centrum Nauki, Poland
2023/05 - 2023/05	Post-doctoral grant applications reviewer, Genopole-ApogeeBio-2023; France	Genopole, France
2023 - 2023	Reviewer, Postdoctoral Junior Leader Fellowships - Retaining 2023, 'la Caixa' Foundation; Spain	Fundación "la Caixa", Spain
2021 - 2023	Grant application reviewer, Bilateral cooperation calls 2019-2021, FCT	Fundação para a Ciência e a Tecnologia, Portugal
2022 - 2022	Grant Application Remote Reviewer, ERC Advanced Grant 2021	European Research Council, Belgium
2022 - 2022	Postdoctoral Grant Application Reviewer, FWO, Belgium	Fonds Wetenschappelijk Onderzoek Vlaanderen, Belgium
2017 - 2017	Young Investigator Award Committee EFMC	European Federation for Medicinal Chemistry, Belgium
2016 - 2016	Grant application reviewer, generic call, Agence Nationale de la Recherche; France	Agence nationale de la recherche, France
2014 - 2016	Application reviewer, Pfizer/ Sociedade de Ciências Médicas de Lisboa Award in Basic Research	Pfizer Biofarmacêutica Sociedade Unipessoal Lda, Portugal
2014 - 2015	Young Investigator Award Committee, Division of Chemical Toxicology	American Chemical Society, United States
2013 - 2013	Grant reviewer, ERC Advanced Grant	European Research Council, Belgium
2011 - 2012	TOXI Awards Committee (Founders Award and ACS Fellows Program), Division of Chemical Toxicology	American Chemical Society, United States
2007 - 2007	Grant reviewer, Post-doctoral fellowship applications, FCT	Fundação para a Ciência e a Tecnologia, Portugal
2004 - 2004	PhD fellowship appplication reviewer, Fundação Oriente	Fundação Oriente, Portugal
2001 - 2001	Grant reviewer, Programa Gulbenkian de Estímulo à Investigação, Chemical Synthesis	Fundação Calouste Gulbenkian, Portugal

Distinctions

Other distinction

2015	Coordinator, ‘MEDLife - Medicinal and Biological Chemistry for Health’ Thematic Line, CQE-IST (2015-2023)
2008	Vice-chair, Centro de Química Estrutural, Instituto Superior Técnico (CQE-IST) (2008- 2023)
2006	Coordinator, Synthesis, Molecular Structure and Chemical Analysis Division, Chemical (and Biological) Engineering Department, IST (2006-2009; 2015-2020)
2005	Scientific Coordinator, Organic and Bioorganic Chemistry Research Group, CQE-IST (2005-2014)
2003	Coordinator, Undergraduate and Graduate Chemistry Programs, IST (2003-2016)
2001	Member, Board of Directors, IST (2001-2002)
1999	Vice-chair, Chemical Engineering Department, IST (1999-2000; 2011-2016)
1997	Coordinator, Organic Chemistry Division, Chemical Engineering Department, IST (1997- 1999).