???global.info.a_carregar???
José Soares. Concluiu o(a) Mestrado integrado em Ciências Farmacêuticas em 2011/11/08 pelo(a) Universidade do Porto Faculdade de Farmácia. É Investigador no(a) Universidade do Porto Faculdade de Farmácia. Publicou 15 artigos em revistas especializadas. Possui 1 capítulo(s) de livros. Organizou 1 evento(s). Participou em 35 evento(s). Participa e/ou participou como Outra em 1 projeto(s). Nas suas atividades profissionais interagiu com 89 colaborador(es) em coautorias de trabalhos científicos. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: marine; xanthones; antimicrobial; physicochemical properties; ADME; Semiconductor quantum dots; Surface chemistry; Thiol-based ligands; Chemometrics; Multiparametric analysis; Metals; Lipophilicity; Drug-membrane interactions; Membrane models; COSMOmic; Liposomes; Micelles; Membrane biophysics; Xanthone derivatives; RP-HPLC; RP-HPTLC; VALLME-HPLC; Biomembrane model; Quantum dots; Chemosensor; Nanomaterials; Photoluminescence; Chemical analysis; CdTe quantum dots; Heavy metals; Multiplexing; Fluorescence; Krokodil; Opioids; Morphinans; LC-ESI-IT-Orbitrap-MS; Analgesia; desomorphine; in vivo; krokodil; phosphorous; toxicity; Quantum Yield; Central Composite Design Method; Sodium Tellurite; Conventional Hydrothermal Synthesis; Hydrothermal Synthetic Route; Opioid abuse; Desomorphine; “Krokodil” synthesis; GC-EI/MS analysis; Propranolol; Acebutolol ; Fluorescence techniques; X-ray scattering; Xanthones; Xanthen-9-ones; Antitumor; Benzopyran; Chromans; Chromene; "Krokodil"; 1H NMR; FTIR; Street like synthesis; TLC profile; UV/Vis; Marine products; Synthesis; Chemotherapic agents; Nanotechnology; .
Read full resume ↓
Identification

Personal identification

Full name
José Soares

Citation names

  • Soares, José

Author identifiers

Ciência ID
AE13-015C-A991
ORCID iD
0000-0001-8496-156X
Google Scholar ID
inBfXxAAAAAJ&hl
Researcher Id
D-7574-2016
Scopus Author Id
55581059600
Education
Degree Classification
2011/11/08
Concluded
 Ciências Farmacêuticas (Mestrado integrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"n/a" (THESIS/DISSERTATION)
 16 valores
Affiliation

Science

Category
Host institution 		Employer
2014/12/01 - Current Researcher (Research) Universidade do Porto Faculdade de Farmácia, Portugal
2017/05/01 - 2017/10/31 Visiting Researcher (Research) Bundesanstalt für Materialforschung und -prüfung, Germany

Teaching in Higher Education

Category
Host institution 		Employer
2019/09 - Current Invited Assistant (University Teacher) Universidade do Porto Faculdade de Farmácia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2012/09/01 - 2014/11/30 Invited Assistant (University Teacher) Universidade do Porto Faculdade de Farmácia, Portugal
Projects

Contract

Designation Funders
2022/01/01 - 2024/12/31 Sustainable antifouling agents: from grape wastes to the sea with the green chemistry leading the way
PTDC/CTA-AMB/0853/2021
Researcher
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/01/01 - 2018 Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents
P2020-PTDC/MAR-BIO/4694/2014
Post-doc
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Concluded
Outputs

Publications

Book chapter
  1. João L. M. Santos; Soares, José X.; Rodrigues, S. Sofia M.; David S. M. Ribeiro. "Semiconductor Quantum Dots in Chemical Analysis". In Handbook of Smart Materials in Analytical Chemistry, edited by Miguel de la Guardia; Francesc A. Esteve-Turrillas, 309-343. John Wiley & Sons, Ltd, 2019.
    10.1002/9781119422587.ch10
  2. Santos, Joao L. M.; Soares, Jose X.; Rodrigues, S. Sofia M.; Ribeiro, David S. M.. "Quantum Dots: Light Emitters for Diagnostics and Therapeutics". In Nanoparticles in Life Sciences and Biomedicine, edited by Ana Rute Neves; Salette Reis, 467-501. Singapura, Singapore: Pan Stanford Publishing Pte. Ltd., 2018.
    Published
Conference paper
  1. Loureiro, Daniela R. P.; Soares, José; Nunes, Cláudia; Afonso, Carlos M. M.; Reis, Salette. "Optimization of Lipid-Based Ceftriaxone Delivery System via Machine Learning". Paper presented in International Electronic Conference on Medicinal Chemistry, 2022.
    Published • 10.3390/ecmc2022-13415
  2. Azevedo, C. M. G.; Soares, J. X.; Afonso, C. M. M.; Reis, S.; Pinto, M. M.; Afonso, C. M.; Pinto, M.. "Synthesis and Physicochemical Properties of Xanthone Derivatives with Potential Antitumor Activity". Paper presented in 2º Encontro Nacional de Química Terapêutica, Coimbra, 2010.
    Published
Conference poster
  1. Ana Laura Dias; Cravo, Sara; Soares, José; Madalena M. M. Pinto; Afonso, Carlos; Correia-da-Silva, Marta. "Eco-friendly synthesis of a new antifouling agent: one step towards the scale-up process". Paper presented in Blue Think Conference, 2022.
  2. Afonso, Inês; Daniela R. P. Loureiro; Ana Laura Dias; Soares, José; Madalena M. M. Pinto; Afonso, Carlos. "Synthesis of analogues of a hit antitumor pyranoxanthone". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022.
  3. Ana Laura Dias; Daniela R. P. Loureiro; Soares, José; Madalena M. M. Pinto; Afonso, Carlos. "A novel palladium-catalyzed synthetic route to obtain a key xanthonic chemical precursor of potential antitumor pyranoxanthones". Paper presented in XXVII Encontro Nacional Sociedade Portuguesa de Química, 2021.
  4. Daniela R. P. Loureiro; Soares, José; Nunes, Cláudia; Afonso, Carlos; Reis, Salette. "Synthesis of DSPE-PEG2000-NH2-D-amino acids conjugates to overcome the biofilm formation caused by Staphylococcus aureus". Paper presented in XXVII Encontro Nacional da Sociedade Portuguesa de Química, 2021.
  5. Ana Laura Dias; Daniela R. P. Loureiro; Soares, José; Madalena M. M. Pinto; Afonso, Carlos. "A novel route to obtain a xanthonic building block for the synthesis of potential antitumor pyranoxanthone derivatives". Paper presented in IJUP’21, 14th Meeting of Young Researchers of University of Porto, 2021.
  6. Afonso, Inês; Daniela R. P. Loureiro; Ana Laura Dias; Soares, José; Azevedo, Carlos M. G.; Madalena M. M. Pinto; Afonso, Carlos. "Synthesis of analogues of hit pyranoxanthones with potential antitumor activity". Paper presented in IJUP’21, 14th Meeting of Young Researchers of University of Porto, University of Porto,, 2021.
  7. Godinho, Sara; Ana Laura Dias; Daniela R. P. Loureiro; Soares, José; Madalena M. M. Pinto; Afonso, Carlos. "Synthesis of an important precursor of bioactive xanthone derivatives". Paper presented in IJUP’21, 14th Meeting of Young Researchers of University of Porto, University of Porto,, 2021.
  8. Maia, A.; Loureiro, D. R. P.; Soares, J. X.; Lopes, D.; Azevedo, C. M. G.; Pinto, M.; Reis, S.; Afonso, C. M. M.; Afonso, C. M.. "Evaluating the lipophilicity of drugs using liposomes". Paper presented in iMed Conference 10.0, 2018.
  9. Soares, J. X.; Ribeiro, D. S. M.; Castro, R. C.; Resch-Genger, Ute; Santos, J. L. M.. "Green And Chiral Quantum Dots". Paper presented in Analítica - 2018 - 9th Meeting of the Analytical Chemistry Division, 2018.
  10. Magalhães, Á. F.; Soares, J. X.; Loureiro, D. R. P.; Cravo, S.; Azevedo, C. M. G.; Afonso, C. M.; Pinto, M.. "Marine xanthones: total synthesis and in silico ADME profile". Paper presented in Escola de Inverno de Farmácia – EIF2018, 2018.
  11. Vilaranda, A. G.; Neves, A. F. D. C. ; Azevedo, A. M. O. ; Soares, J. X.; Santos, J. L. M.; Saraiva, M. L. M. F. S.. "Synthesis and biodegradability of choline-based deep eutectic solvents". Paper presented in 11th Meeting of Young Researchers at UP - IJUP’18, 2018.
  12. Vilares, J. P.; Faria, G.; Magalhães, Á. F.; Loureiro, D. R. P.; Soares, J. X.; Azevedo, C. M. G.; Pinto, M.; Afonso, C. M. M.. "Synthesis of xanthone derivatives with potential antimicrobial activity". Paper presented in 11th Meeting of Young Researchers at UP - IJUP’18, 2018.
  13. Magalhães, Á. F.; Soares, J. X.; Loureiro, D. R. P.; Pinto, J.; Cravo, S.; Azevedo, C. M. G.; Afonso, C. M.; Pinto, M.. "Synthesis and in silico biophysicochemical properties of marine xanthones and derivatives". Paper presented in 12º Encontro Nacional de Química Orgânica e 5º Encontro de Química Terapêutica, 2018.
  14. Neves, A. F.D.C. ; Vilaranda, A. G.; Azevedo, A. M.O. ; Soares, J. X.; Lapa, R. A. S.; Santos, J. L. M.; Esperança, J. M. S. S.; Saraiva, M. L. M. F. S.. "Insights into the synthesis of deep eutectic solvents by the heating method". Paper presented in 10th Meeting of Young Researchers at UP - IJUP’17, 2017.
  15. Magalhães, Á. F.; Soares, J. X.; Loureiro, D. R. P.; Pinto, J.; Cravo, S.; Azevedo, C. M. G.; Afonso, C. M. M.; Pinto, M.. "Routes to benzophenones: exploration of two different synthetic pathways". Paper presented in 10th Meeting of Young Researchers at UP - IJUP’17, 2017.
  16. Reis, L.; Soares, J. X.; Ribeiro, D. S. M.; Santos, J. L. M.; Pinto, M. M.; Afonso, C. M.. "MW-assisted synthesis of fluorescent carbon dots using deep eutectic solvents". Paper presented in 10th Meeting of Young Researchers at UP - IJUP’17, 2017.
  17. Castro, R. C.; Ribeiro, D. S. M.; Soares, J. X.; Rodrigues, S. S. M.; Santos, J. L. M.. "Dual-emission ratiometric probe based on the photoluminescence blue-emitting carbon dots and red-emitting CdTe quantum dots for H2O2 determination". Paper presented in Analítica - 2016 - 8th Meeting of the Analytical Chemistry Division, 2016.
  18. Castro, R. C.; Ribeiro, D. S. M.; Soares, J. X.; Rodrigues, S. S. M.; Santos, J. L. M.. "Nanohybrid carbon dots/GSH-CdTe/MPA-CdTe quantum dots system for the selective detection of ions in water". Paper presented in Analítica - 2016 - 8th Meeting of the Analytical Chemistry Division, 2016.
  19. Ribeiro, D. S. M.; Melo, L. M. L. S.; Rodrigues, S. S. M.; Soares, J. X.; Santos, J. L. M.. "Microwave-assisted aqueous synthesis of CdTe quantum dots as photoluminescent probes for determination of metformin". Paper presented in Analítica - 2016 - 8th Meeting of the Analytical Chemistry Division, 2016.
  20. Rodrigues, S. S. M.; Magalhães, M. J.; Ribeiro, D. S. M.; Soares, J. X.; Santos, J. L. M.. "Synthesis and modification of fluorescent semiconductor nanocrystals for use in non-aqueous medium". Paper presented in Analítica - 2016 - 8th Meeting of the Analytical Chemistry Division, 2016.
  21. Soares, J. X.; Castro, R. C.; Ribeiro, D. S. M.; Rodrigues, S. S. M.; Santos, J. L. M.. "Paper-based sensor with N-doped carbons dots for iron(iii) detection". Paper presented in Analítica - 2016 - 8th Meeting of the Analytical Chemistry Division, 2016.
  22. Loureiro, D. R. P.; Soares, J. X.; Cravo, S.; Salvador, J.; Azevedo, C. M. G.; Pinto, M.; Afonso, C. M.. "Preparation of two building blocks for the synthesis of yicathins B and C". Paper presented in 5th Portuguese Young Chemists Meeting, 2016.
  23. Loureiro, D. R. P.; Soares, J. X.; Cravo, S.; Salvador, J.; Azevedo, C. M. G.; Afonso, C. M.. "Designing the total synthesis of two marine xanthones: yicathins B and C". Paper presented in 9th Meeting of Young Researchers at UP - IJUP’16, 2016.
  24. Macedo, T.; Soares, J. X.; Lopes, D.; Nunes, C.; Reis, S.; Afonso, C. M.. "Biomembrane models evaluation in drug discovery". Paper presented in 9th Meeting of Young Researchers at UP - IJUP’16, 2016.
  25. Neves, J. F.; Soares, J. X.; Alves, E. A.; Cravo, S.; Silva, A. M. S.; Netto, A. D.; Carvalho, F.; et al. "The homemade drug “Krokodil”: chromatographic and spectroscopy studies". Paper presented in 9th Meeting of Young Researchers at UP - IJUP’16, 2016.
  26. Santos, Á.; Soares, J. X.; Cravo, S.; Tiritan, M.E.; Fernandes, C.; Afonso, C. M.; Pinto, M.. "Determination of the lipophilicity of chiral derivatives of xanthones: comparison of methods". Paper presented in 9th Meeting of Young Researchers at UP - IJUP’16, 2016.
  27. Fernandes, C.; Santos, Á.; Soares, J. X.; Cravo, S.; Tiritan, M.E.; Afonso, C. M.; Pinto, M.. "An example of the key role of HPLC in Medicinal Chemistry: determination of lipophilicity of a xanthone derivatives library". Paper presented in 11º Congresso de Química Orgânica e Química Terapêutica, 2015.
  28. Alves, E. A.; Soares, J. X.; Ferreira, A. S.; Cravo, S.; Neves, J. F.; Netto, A. D.; Carvalho, F.; Dinis Oliveira, R. J.. "Synthesis of the “Krokodil” drug through “street” reported methods and product analysis". Paper presented in 53rd Annual Meeting of the International Association of Forensic Toxicologists, 2015.
  29. Soares, J. X.; Ribeiro, David S. M.; Santos, J. L. M.. "Optimization of microwave-assisted synthesis of N-doped carbon dots". Paper presented in XXIV Encontro Nacional da Sociedade de Portuguesa de Química, 2015.
  30. Marques, D.; Soares, J. X.; Neves, J. F.; Vieira, R.; Azevedo, C. M. G.; Pinto, M.; Afonso, C. M. M.. "Synthesis of key intermediates for the obtention of potential antitumor XC36 derivatives". Paper presented in XX Encontro Luso-Galego de Química, 2014.
  31. Soares, J. X.; Marques, D.; Neves, J. F.; Vieira, R.; Reis, S.; Pinto, M.; Azevedo, C. M. G.; Afonso, C. M.. "Multidimensional Optimization of Potential Antitumor Pyranoxanthones: Synthesis and Pharmacokinetics". Paper presented in XXIII International Symposium on Medicinal Chemistry, 2014.
  32. Marques, D.; Neves, J. F.; Vieira, R.; Soares, J. X.; Reis, S.; Pinto, M.; Azevedo, C. M. G.; Afonso, C. M. M.. "Expanding the chemical space of antitumor xanthones: a new route paved by a chromene moiety". Paper presented in 7th Meeting of Young Researchers at UP - IJUP’14, 2014.
  33. Neves, J. F.; Marques, D.; Vieira, R.; Soares, J. X.; Reis, S.; Pinto, M.; Azevedo, C. M. G.; Afonso, C. M. M.. "Potential antitumour xanthones: synthesis and pharmacokinetics". Paper presented in 7th Meeting of Young Researchers at UP - IJUP’14, 2014.
  34. Vieira, R.; Marques, D.; Neves, J. F.; Soares, J. X.; Palmeira, A.; Reis, S.; Pinto, M.; Azevedo, C. M. G.; Afonso, C. M.. "A computational study to investigate the binding of new potential antitumor xanthone derivatives to human serum albumin". Paper presented in 7th Meeting of Young Researchers at UP - IJUP’14, 2014.
  35. Marques, D.; Vieira, R.; Neves, J. F.; Soares, J. X.; Azevedo, C. M. G.; Afonso, C. M.; Reis, S.; Pinto, M.. "Multidimensional optimization of xanthones with potential antitumor activity: plasma protein binding". Paper presented in 6th Meeting of Young Researchers at UP - IJUP’13, 2013.
  36. Azevedo, C. M. G.; Soares, J. X.; Afonso, C. M. M.; Reis, S.; Pinto, M.. "Synthesis of pyranoxanthones using platinum and gold catalysts". Paper presented in XVI Encontro Luso-Galego de Química, 2010.
  37. Soares, J. X.; Azevedo, C. M. G.; Afonso, C. M.; Reis, S.; Pinto, M.. "Synthesis, Physico-chemical Properties and Biological Activity of some derivatives of XP13, a xanthone with promising antitumoral activity". Paper presented in 3rd Meeting of Young Researchers at UP - IJUP’10, 2010.
Journal article
  1. José X. Soares; Álvaro Santos; Carla Fernandes; Madalena M. M. Pinto. "Liquid Chromatography on the Different Methods for the Determination of Lipophilicity: An Essential Analytical Tool in Medicinal Chemistry". Chemosensors (2022): https://doi.org/10.3390/chemosensors10080340.
    10.3390/chemosensors10080340
  2. José X. Soares; Daniela R. P. Loureiro; Ana Laura Dias; Reis, Salette; Madalena M. M. Pinto; Afonso, Carlos. Corresponding author: Afonso, Carlos. "Bioactive Marine Xanthones: A Review". Marine Drugs 20 1 (2022): 58-58. http://dx.doi.org/10.3390/md20010058.
    Published • 10.3390/md20010058
  3. Mazivila, Sarmento J. ; José X. Soares; Santos, João L.M.. "A tutorial on multi-way data processing of excitation-emission fluorescence matrices acquired from semiconductor quantum dots sensing platforms". Analytica Chimica Acta (2021): 339216-339216. https://doi.org/10.1016/j.aca.2021.339216.
    10.1016/j.aca.2021.339216
  4. Rafael C. Castro; Lopes, André F. R.; Soares, José X.; David S. M. Ribeiro; João L. M. Santos; Soares, José. "Determination of atenolol based on the reversion of the fluorescence resonance energy transfer between AgInS2 quantum dots and Au nanoparticles". The Analyst 146 3 (2021): 1004-1015. http://dx.doi.org/10.1039/d0an01874k.
    Published • 10.1039/d0an01874k
  5. França, Fábio; Silva, Patrícia M. A.; Soares, José X.; Henriques, Ana C.; Daniela R. P. Loureiro; Azevedo, Carlos M. G.; Carlos M. M. Afonso; Bousbaa, Hassan. "A Pyranoxanthone as a Potent Antimitotic and Sensitizer of Cancer Cells to Low Doses of Paclitaxel". Molecules 25 24 (2020): 5845. http://dx.doi.org/10.3390/molecules25245845.
    Open access • Published • 10.3390/molecules25245845
  6. David S. M. Ribeiro; Rafael C. Castro; Soares, José; João L. M. Santos. "Photocatalytic activity of AgInS2 quantum dots upon visible light irradiation for melatonin determination through its reactive oxygen species scavenging effect". Microchemical Journal 155 (2020): 104728-104728. http://dx.doi.org/10.1016/j.microc.2020.104728.
    10.1016/j.microc.2020.104728
  7. Rafael C. Castro; David S. M. Ribeiro; Soares, José X.; Mazivila, Sarmento J.; João L. M. Santos. "Dual-emission CdTe/AgInS2 photoluminescence probe coupled to neural network data processing for the simultaneous determination of folic acid and iron (II)". Analytica Chimica Acta 1114 (2020): 29-41. http://dx.doi.org/10.1016/j.aca.2020.04.007.
    Published • 10.1016/j.aca.2020.04.007
  8. Daniela R. P. Loureiro; Magalhães, Álvaro F.; A.A. Soares; Pinto, Joana; Azevedo, Carlos M. G.; Vieira, Sara; Henriques, Ana; et al. "Yicathins B and C and Analogues: Total Synthesis, Lipophilicity and Biological Activities". ChemMedChem 15 9 (2020): 749-755. http://dx.doi.org/10.1002/cmdc.201900735.
    Published • 10.1002/cmdc.201900735
  9. Soares, J.X.; Wegner, K.D.; Ribeiro, D.S.M.; Melo, A.; Häusler, I.; Santos, J.L.M.; Resch-Genger, U.. "Rationally designed synthesis of bright AgInS2/ZnS quantum dots with emission control". Nano Research (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85087071984&partnerID=MN8TOARS.
    10.1007/s12274-020-2876-8
  10. Pinto, Patricia; Machado, Carmen Mariana; Moreira, Joana; Almeida, José Diogo P.; Silva, Patrícia M.A.; Henriques, Ana C.; Soares, José X.; et al. "Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor activity and lipophilicity". European Journal of Medicinal Chemistry 184 (2019): 111752. http://dx.doi.org/10.1016/j.ejmech.2019.111752.
    Published • 10.1016/j.ejmech.2019.111752
  11. Soares, José. "Photoluminescence of Ag-In-S/ZnS quantum dots: Excitation energy dependence and low-energy electronic structure". Nano Research 12 7 (2019): 1595-1603. http://dx.doi.org/10.1007/s12274-019-2398-4.
    10.1007/s12274-019-2398-4
  12. Ribeiro, David S.M.; Castro, Rafael C.; Páscoa, Ricardo N.M.J.; Soares, José X.; Rodrigues, S. Sofia M.; Santos, João L.M.. "Tuning CdTe quantum dots reactivity for multipoint detection of mercury(II), silver(I) and copper(II)". Journal of Luminescence 207 (2019): 386-396. http://dx.doi.org/10.1016/j.jlumin.2018.11.035.
    Published • 10.1016/j.jlumin.2018.11.035
  13. Loureiro, Daniela R. P.; Soares, José X.; Costa, Joana C.; Magalhães, Álvaro F.; Azevedo, Carlos M. G.; Pinto, Madalena M. M.; Afonso, Carlos M. M.. "Structures, Activities and Drug-Likeness of Anti-Infective Xanthone Derivatives Isolated from the Marine Environment: A Review". Molecules 24 2 (2019): 243. http://dx.doi.org/10.3390/molecules24020243.
    Open access • 10.3390/molecules24020243
  14. Castro, R.C.; Soares, J.X.; Ribeiro, D.S.M.; Santos, J.L.M.. "Dual-emission ratiometric probe combining carbon dots and CdTe quantum dots for fluorometric and visual determination of H2O2". Sensors and Actuators, B: Chemical 296 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85067497612&partnerID=MN8TOARS.
    10.1016/j.snb.2019.126665
  15. Loureiro, Daniela R.P.; Soares, José X.; Lopes, Daniela; Macedo, Tiago; Yordanova, Denitsa; Jakobtorweihen, Sven; Nunes, Cláudia; et al. "Accessing lipophilicity of drugs with biomimetic models: A comparative study using liposomes and micelles". European Journal of Pharmaceutical Sciences 115 (2018): 369-380. http://dx.doi.org/10.1016/j.ejps.2018.01.029.
    Published • 10.1016/j.ejps.2018.01.029
  16. Santos, Álvaro; Soares, José Xavier; Cravo, Sara; Tiritan, Maria E.; Reis, Salette; Afonso, Carlos; Fernandes, Carla; Pinto, Madalena M. M.; Pinto, Madalena M.M.. "Lipophilicity assessement in drug discovery: Experimental and theoretical methods applied to xanthone derivatives". Journal of Chromatography B 1072 Supplement (2018): 182-192. http://www.sciencedirect.com/science/article/pii/S1570023217314307.
    Published • https://doi.org/10.1016/j.jchromb.2017.10.018
  17. Soares, José Xavier; Alves, Emanuele Amorim; Silva, André M. N.; de Figueiredo, Natália Guimarães; Neves, João F.; Cravo, Sara Manuela; Rangel, Maria; et al. "Street-Like Synthesis of Krokodil Results in the Formation of an Enlarged Cluster of Known and New Morphinans". Chemical Research in Toxicology 30 8 (2017): 1609-1621. http://dx.doi.org/10.1021/acs.chemrestox.7b00126.
    Published • 10.1021/acs.chemrestox.7b00126
  18. Alves, Emanuele Amorim; Brandão, Pedro; Neves, João Filipe; Cravo, Sara Manuela; Soares, José Xavier; Grund, Jean-Paul C.; Duarte, José Alberto; et al. "Repeated subcutaneous administrations of krokodil causes skin necrosis and internal organs toxicity in Wistar rats: putative human implications". Human Psychopharmacology: Clinical and Experimental 32 3 (2017): e2572. http://dx.doi.org/10.1002/hup.2572.
    Open access • Published • 10.1002/hup.2572
  19. Ribeiro, David S. M.; de Souza, Gustavo C. S.; Melo, Armindo; Soares, José X.; Rodrigues, S. Sofia M.; Araújo, Alberto N.; Montenegro, Maria Conceição B. S. M.; Santos, João L. M.. "Synthesis of distinctly thiol-capped CdTe quantum dots under microwave heating: multivariate optimization and characterization". Journal of Materials Science 52 6 (2017): 3208-3224. http://dx.doi.org/10.1007/s10853-016-0610-4.
    Published • 10.1007/s10853-016-0610-4
  20. Rodrigues, S. Sofia M.; Ribeiro, David S.M.; Soares, José X.; Passos, Marieta L.C.; Saraiva, M. Lúcia M.F.S.; Santos, João L.M.. "Application of nanocrystalline CdTe quantum dots in chemical analysis: Implementation of chemo-sensing schemes based on analyte-triggered photoluminescence modulation". Coordination Chemistry Reviews 330 (2017): 127-143. http://dx.doi.org/10.1016/j.ccr.2016.10.001.
    Published • 10.1016/j.ccr.2016.10.001
  21. Bittar, Dayana B.; Ribeiro, David S. M.; Páscoa, Ricardo N. M. J.; Soares, José X.; Rodrigues, S. Sofia M.; Castro, Rafael C.; Pezza, Leonardo; et al. "Multiplexed analysis combining distinctly-sized CdTe-MPA quantum dots and chemometrics for multiple mutually interfering analyte determination". Talanta 174 (2017): 572-580. http://www.sciencedirect.com/science/article/pii/S0039914017307026.
    Published • https://doi.org/10.1016/j.talanta.2017.06.071
  22. Alves, E. A.; Soares, J. X.; Silva, A. M.; Neves, J. F.; Cravo, S. M.; Rangel, M.; Afonso, C. M.; et al. "Identification of a complex mixture of opioids on krokodil street-like samples". Toxicology Letters 258 (2016): S300-S300. http://dx.doi.org/10.1016/j.toxlet.2016.06.2039.
    Published • 10.1016/j.toxlet.2016.06.2039
  23. Alves, E.A.; Brandão, P.; Neves, J.F.; Cravo, S.M.; Soares, J.X.; Duarte, J.A.; Grund, J.C.; et al. "Short-term toxicodynamics of krokodil in wistar rats following repeated subcutaneous administration". Toxicology Letters 258 (2016): S130. http://dx.doi.org/10.1016/j.toxlet.2016.06.1514.
    Published • 10.1016/j.toxlet.2016.06.1514
  24. Neves, João Filipe; Alves, Emanuele Amorim; Soares, José Xavier; Cravo, Sara Manuela; Silva, Artur M.S.; Pereira Netto, Annibal Duarte; Carvalho, Félix; Dinis-Oliveira, Ricardo Jorge; Afonso, Carlos Manuel. "Data analysis of “krokodil” samples obtained by street-like synthesis". Data in Brief 6 (2016): 83-88. http://dx.doi.org/10.1016/j.dib.2015.11.046.
    Open access • Published • 10.1016/j.dib.2015.11.046
  25. Alves, Emanuele Amorim; Soares, José Xavier; Afonso, Carlos Manuel; Grund, Jean-Paul C.; Agonia, Ana Sofia; Cravo, Sara Manuela; Netto, Annibal Duarte Pereira; Carvalho, Félix; Dinis-Oliveira, Ricardo Jorge. "The harmful chemistry behind “krokodil”: Street-like synthesis and product analysis". Forensic Science International 257 (2015): 76-82. http://dx.doi.org/10.1016/j.forsciint.2015.07.042.
    Published • 10.1016/j.forsciint.2015.07.042
  26. Azevedo, Carlos M.G.; Afonso, Carlos M.M.; Soares, José X.; Reis, Salette; Sousa, Diana; Lima, Raquel T.; Vasconcelos, M. Helena; et al. "Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models". European Journal of Medicinal Chemistry 69 (2013): 798-816. http://dx.doi.org/10.1016/j.ejmech.2013.09.012.
    Published • 10.1016/j.ejmech.2013.09.012
  27. Pereira-Leite, Catarina; Carneiro, Cláudia; Soares, José X.; Afonso, Carlos; Nunes, Cláudia; Lúcio, Marlene; Reis, Salette. "Biophysical characterization of the drug–membrane interactions: The case of propranolol and acebutolol". European Journal of Pharmaceutics and Biopharmaceutics 84 1 (2013): 183-191. http://dx.doi.org/10.1016/j.ejpb.2012.12.005.
    Published • 10.1016/j.ejpb.2012.12.005
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/02/06 Ceftriaxone-loaded lipid nanoparticles with antibiofilm activity to treat prosthetic joint infections 4th SPLC-CRS Young Scientists Meeting
Spanish-Portuguese Chapter of Controlled Release Society (Porto, Portugal)
2022/11/17 Irá a inteligência artificial assumir o papel do Químico? Um estudo de caso com a reação carbonilativa de Suzuki XXVI Galician-Portuguese International Conference on Chemistry
Colégio Oficial de Químicos da Galiza (Santiago de Compostela, Spain)
2022/04/21 Augmenting chemical intuition for reaction optimization with active machine learning: application in the optimization of carbonylative Suzuki coupling 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting
Sociedade Portuguesa de Química (Costa da Caparica, Portugal)
2020/01/17 A novel route to the synthesis of xanthones by carbonylative Suzuki coupling 13th National Organic Chemistry Meeting - 6th National Medicinal Chemistry Meeting (13ENQO-6ENQT)
Portuguese Chemical Society (SPQ) (Aveiro, Portugal)
2018/11/21 New routes for the synthesis of marine xanthones with antimicrobial activity XXIV Encontro Luso-Galego de Qui´mica
Portuguese Society of Chemistry (Porto, Portugal)
2018/11/21 Rational optimization of the microwave-assisted synthesis of bright ternary AgInS2/ZnS quantum dots XXIV Encontro Luso-Galego de Qui´mica
Portuguese Society of Chemistry (Porto, Portugal)
2018/03/26 Ternary semiconductor quantum dots for chemical analysis Analítica - 2018 - 9th Meeting of the Analytical Chemistry Division
Portuguese Society of Chemistry (Porto, Portugal)
2018/03/07 Synthesis of two important building blocks of antimicrobial marine xanthones Escola de Inverno de Farmácia – EIF2018
Instituto de Desenvolvimento Humano Integral Aplicado (Porto, Portugal)
2018/02/07 Quantum dots differential reactivity for iron (Fe2+ and Fe3+) speciation 11th Meeting of Young Researchers at UP - IJUP’18
University of Porto (Porto, Portugal)
2018/02/07 Route to xanthone derivatives and in silico determination of their biophysicochemical properties 11th Meeting of Young Researchers at UP - IJUP’18
University of Porto (Porto, Portugal)
2018/01/17 Selecting the right tools in drug discovery: lipophilicity determination with biomimetic models 12º Encontro Nacional de Química Orgânica e 5º Encontro de Química Terapêutica
Portuguese Society of Chemistry (Coimbra, Portugal)
2017/02/08 Amendment of CdTe quantum dots reactivity upon selection of appropriate capping ligands 10th Meeting of Young Researchers at UP - IJUP’17
University of Porto (Porto, Portugal)
2017/02/08 Biomimetic models for determination of lipophilicity in drug discovery 10th Meeting of Young Researchers at UP - IJUP’17
University of Porto (Porto, Portugal)
2015/12/01 Unveiling the Chemistry of the Homemade Drug "Krokodil" 11º Encontro Nacional de Química Orgânica e 4º Encontro de Química Terapêutica
Portuguese Society of Chemistry (Porto, Portugal)
2015/12/01 Lessons from the study of the binding mechanism of “hit” compounds to albumin: fluorescence and in silico study applied to xanthones derivatives 11º Encontro Nacional de Química Orgânica e 4º Encontro de Química Terapêutica
Portuguese Society of Chemistry (Porto, Portugal)
2015/07/05 Chemo-sensing based on analyte-triggered modulation of CdTe quantum dots photoluminescence Flow Analysis XIII
Charles University (Prague, Czech Republic)
2015/05/13 Chemical composition of “Krokodil”: revealing a new street drug 8th Meeting of Young Researchers at UP - IJUP’15
University of Porto (Porto, Portugal)
2015/02/05 Unveiling the psychotropic and toxic constituents of Krokodil, following the street chemical synthesis procedure. Annual Meeting of Portuguese Pharmacology Society
Portuguese Pharmacology Society (Lisboa, Portugal)
2014/11/26 Synthesis and composition of the street drug “Krokodil” XX Encontro Luso-Galego de Química
Sociedade Portuguesa de Química (Porto, Portugal)
2014/11/24 Synthesis and in silico study of potential antitumor activity of xanthones XX Encontro Luso-Galego de Química
Sociedade Portuguesa de Química (Porto, Portugal)
2014/10/30 Krokodil: Bad Chemistry Hurts 1st National Institute of Legal Medicine and Forensic Science Conference
National Institute of Legal Medicine and Forensic Science (Coimbra, Portugal)
2013/09/04 Multidimensional optimization of pyranoxanthones with potential antitumor activity 10º Encontro Nacional de Química Orgânica
Portuguese Society of Chemistry (Lisboa, Portugal)
2013/02/13 Binding mechanism of new potential antitumor molecules to albumin: a fluorescence and computational study applied to xanthone derivatives 6th Meeting of Young Researchers at UP - IJUP’13
University of Porto (Porto, Portugal)
2012/02/22 Diclofenac interactions with lipid membranes - insight into the NSAIDs-induced gastrointestinal toxicity 5th Meeting of Young Researchers at UP - IJUP’12
University of Porto (Porto, Portugal)
2011/10/13 Multidimensional Optimization of Xanthone Derivatives with Potential Antitumor Activity III Congress of the Portuguese Society of Pharmaceutical Sciences/ IX Spanish-Portuguese Conference on Controlled Drug Delivery – New Trends in Pharmaceutical Sciences
Portuguese Society of Pharmaceutical Sciences (Porto, Portugal)
2011/02/18 Synthesis and Physicochemical Properties of Xanthone Derivatives with potential Antitumor Activity 4th Meeting of Young Researchers at UP - IJUP’11
University of Porto (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018/09/09 - Current Setting new routes to antimicrobial xanthones derivatives: and synthesis and biological activity
Co-supervisor
 Ciências Farmacêuticas (Scientific initiation)
Universidade do Porto Faculdade de Farmácia, Portugal
2015/09/15 - Current Avaliac¸a~o de modelos biomembranares na descoberta de fa´rmacos
Co-supervisor
 Ciências Farmacêuticas (Scientific initiation)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/09/15 - 2018/07 Synthesis and multidimensional optimization of bioactive marine xanthones
Co-supervisor
 Ciências Farmacêuticas (Scientific initiation)
Universidade do Porto Faculdade de Farmácia, Portugal
2016/09/15 - 2017/07 Síntese de carbon dots fluorescentes assistida por micro-ondas utilizando deep eutectic solvents
Co-supervisor
 Ciências Farmacêuticas (Scientific initiation)
Universidade do Porto Faculdade de Farmácia, Portugal
2014/09/15 - 2015/07/28 The chemistry behind “Krokodil”
Co-supervisor
 Ciências Farmacêuticas (Scientific initiation)
Universidade do Porto Faculdade de Farmácia, Portugal
2013/09/15 - 2014/08/01 Synthesis and molecular docking of potential antitumoral xanthones
Co-supervisor
 Ciências Farmacêuticas (Scientific initiation)
Universidade do Porto Faculdade de Farmácia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2015/01/01 - 2015/06/19 The second edition of Biotech Health symposium, entitled “Biotechnology towards medicine”, was a one-day event aimed to provide a glimpse of that future through interdisciplinary presentations:top (inter)national speakers. (2015/06/19 - 2015/06/19)
Symposium (Co-organisor)
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2017 - Current Métodos Instrumentais de Análise Controlo de Qualidade (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2014 - Current Controlo Químico Controlo de Qualidade (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal

Mentoring / Tutoring

Topic Student name
2016/09 - 2017/07 MSc supervision A´lvaro Filipe Alves Magalha~es
2015/10 - 2016/06 MSc supervision Daniela Raquel Pontes Loureiro