???global.info.a_carregar???
Vilma A. Sardão is an Assistant Investigator at the Multidisciplinary Institute of Ageing (MIA-Portugal), University of Coimbra. She graduated in Biochemistry from the University of Coimbra in 2002 and obtained her Ph.D. in Cell Biology in 2008 at the same University. During her Ph.D. and Postdoc, she had 47 months of International experience at the University of Minnesota-Duluth, USA. She has gathered robust technical laboratory know-how in mitochondrial physiology and respirometry, cell culture, western blot, microscopy, and other cellular and molecular biology methods. Vilma A. Sardão has been focusing her career on mitochondria's role in cell physiology, pathology, and toxicology (>40 published papers). Her scientific background allowed her to establish national and international collaborations in interdisciplinary fields. Her scientific interests focus on mitochondrial remodeling during hormonal status alteration after menopause and the associated development of menopause-associated pathologies. Vilma has currently 53 publications in international peer-reviewed journals (22 in Q1 journals, 14 as first/last author, >1522-2330 citations, h-index 22-27, source: Web of Science/Google Scholar), six book chapters, 21 invited oral communications, more than 40 selected oral communications, and more than 85 posters in national and international conferences. She also obtained some scientific prizes, including the award for student Merit from the University of Coimbra (2002), the Aventis Prize for Scientific Research (2003), and the Graduate Student/Postdoc award, endorsed by the Society for Heart and Vascular Metabolism, 2006.
Read full resume ↓
Identification

Personal identification

Full name
Vilma Marisa Arrojado Soares Sardão Oliveira
Date of birth
1979/09/20
Gender
Female

Citation names

  • Sardão, Vilma

Author identifiers

Ciência ID
AF11-AF31-4912
ORCID iD
0000-0001-7014-4614
Researcher Id
A-1546-2012

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences
  • Medical and Health Sciences - Basic Medicine - Toxicology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2008/02/18
Concluded
 Biology (Doutoramento)
Major in Cellular Biology
University of Coimbra - Faculty of Sciences and Technology, Portugal
"H9c2 Myoblasts as a Tool to Study Doxorubicin-induced Cardiomyopathy - Mechanisms of Cell Death and relevance of Differentiation State" (THESIS/DISSERTATION)
 Aprovado por unanimidade com distinção e louvor
2002/06/27
Concluded
 Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"A Toxicicidade da Cafeína ao Nível da Função Mitocondrial Cardíaca" (THESIS/DISSERTATION)
 16 valores
Affiliation

Science

Category
Host institution 		Employer
2022/04/07 - Current Auxiliary Researcher (Research) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
2016/11/01 - 2021/10/31 Contracted Researcher (Research) University of Coimbra - Center for Neuroscience and Cell Biology, Portugal
University of Coimbra - Center for Neuroscience and Cell Biology, Portugal
2003/02/01 - 2016/10/31 Researcher (Research) Fundação Para a Ciência e Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2001/09/01 - 2002/12/31 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2020/02/01 - Current Invited Assistant Professor (University Teacher) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Ciências do Desporto e Educação Física, Portugal
Projects

Grant

Designation Funders
2015/10/01 - 2016/10/31 stemPREDICT: Bioenergetic Health Index in Human Urine-derived Stem Cells: Role for Differentiation Outcome and Chemical-induced Toxicity
SFRH/BDP/109339/2015
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
2014/05/01 - 2015/09/30 Stemcell based platforms for Regenerative and Therapeutic Medicine
CENTRO-07-ST24-FEDER-002008
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/03/01 - 2014/05/31 Role Of Estrogens In Breast Cancer Cells: Mechanism Of Estrogen-Indiced Breast Cancer Cell Proliferation And Effects Of Hormone Replacement Therapy In Cancer Development
SFRH/BPD/31549/2006
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/09 - 2010/03 Novel Mitochondrial Mechanisms of Doxorubicin-induced Selective Cardiotoxicity
grant.Provided by PTCRIS: 64084
PhD Student Fellow
Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2022/01/04 - Current Human Neuronal Cells Differentiated from Urine-derived Stem Cells as a Platform for Personalized Medicine in Amyotrophic Lateral Sclerosis
PTDC/BTM-ORG/0055/2021
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - Current Preservation of natural and cultural heritage and scientific validation of practices with medicinal plants from Côa Valley
COA/BRB/0019/2019
Researcher
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/12/01 - Current VALORYZEBYPRODUCTS: Preclinical efficacy of sulforaphane or Brassica whole extract: a strategy to fight obesity and valorize Brassica byproduts
PTDC/ASP-HOR/29152/2017
Researcher
Fundação Para a Ciência e Tecnologia
Concluded
2018/05/01 - Current MitoScreening: Development and validation of innovative screening methods for mitochondrial health modulators
PTDC/BTM-SAL/29297/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação Para a Ciência e Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado
LA/P/0058/2020
10.54499/LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/15 - 2025/01/14 Células Neuronais Humanas Diferenciadas a partir de Células Estaminais Derivadas de Urina como Plataforma para a Medicina Personalizada na Esclerose Lateral Amiotrófica
PTDC/BTM-ORG/0055/2021
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2024/12/31 Lifelong exercise: modulating immunometabolic pathways for decreasing cancer risk.
10/22
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Centro Hospitalar e Universitário de Coimbra EPE, Portugal

Universidade de Coimbra Unidade de Investigação e Desenvolvimento Química-Física Molecular, Portugal

Universidade de Coimbra Centro de Investigação do Desporto e da Actividade Física, Portugal
Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia
Ongoing
2022/09/01 - 2024/03/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2023/12/31 Radiocomplexos Dirigidos a Organelos Celulares para Terapia Auger do Cancro
PTDC/MED-QUI/1554/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/06/01 - 2022/02/28 Eficácia pré-clínica do sulforafano ou do extrato total de Brássicas: uma estratégia para combater a obesidade e valorizar os subprodutos de Brássicas
PTDC/ASP-HOR/29152/2017
POCI-01- 0145-FEDER-029152
Universidade de Trás-os-Montes e Alto Douro, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/06 - 2021/12/05 Desenvolvimento e validação de métodos inovadores para triagem de moduladores da saúde mitocondrial
PTDC/BTM-SAL/29297/2017
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017/06 - 2021/10 MitoBone – Orchestrating Osteoclast Differentiation Through ROS and Mitochondrial Regulation
IF/01182/2015
IF/01182/2015
Principal investigator
Fundação Para a Ciência e Tecnologia
Ongoing
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/09/01 - 2019/06/30 FishFree: Uma contribuição para a validação de um ensaio alternativo ao teste letal com peixes
PTDC/AAG-TEC/4966/2014
Researcher
Universidade de Coimbra, Portugal
 Fundação Para a Ciência e Tecnologia
Concluded
2015 - 2018 MitoBOOST: A Next-Generation Therapeutics for Non-Alcoholic Fatty Liver Disease Based on Smart Antioxidant Delivery to Mitochondria
PTDC/DTP-FTO/2433/2014
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Ongoing
2014/05 - 2015/09 Stemcell based platforms for Regenerative and Therapeutic Medicine
CENTRO- 07-ST24-FEDER-002008
CENTRO- 07-ST24-FEDER-002008
PTDC/DTP-FTO/2433/2014
Post-doc Fellow
N/A
Concluded
2013/05 - 2015/08 Pathophysiology of Persistent Doxorubicin Cardiotoxicity: a Mitochondrial-Epigenetics Link
grant.Provided by PTCRIS: 126115
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2010/04/15 - 2013/10/14 Metabolism as a modulator of stem cell pluripotency and differentiation
PTDC/EBB-EBI/101114/2008
Karolinska Institutet, Sweden

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/04 - 2013/09 Can Phytoestrogens be Safe and Effective Food Additives for Women During Menopause? - An In Vitro and In Vivo Approach to the problem.
grant.Provided by PTCRIS: 108326
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2010/04 - 2013/06 Role of Mitochondrial Physiology in Tumor Stem Cell Resistance to Chemotherapeutics
grant.Provided by PTCRIS: 101052
Researcher
Fundação para a Ciência e a Tecnologia
2010/04/01 - 2013/03/31 A Abertura da Caixa de Pandora Para uma Terapia Activa Anti-cancro da Mama - O Papel do Direccionamento Selectivo da Mitocôndria
PTDC/QUI-QUI/101409/2008
University of Minnesota Twin Cities School of Medicine Duluth Campus, United States

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Mercer University School of Medicine, United States
Fundação para a Ciência e a Tecnologia
Concluded
2010/04 - 2013/03 Opening Pandora's Box for Active Anti-Breast Cancer Therapy - The Role of Selective Targeting to Mitochondria
grant.Provided by PTCRIS: 101409
Researcher
Fundação para a Ciência e a Tecnologia
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2012/06/30 Actividade Anticancerígena de Novos Complexos de Pd(II) com Poliaminas - Um Estudo Multidisciplinar
PTDC/QUI/66701/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

École Nationale Supérieure d'Ingénieurs de Caen, France

Universidad de Málaga, Spain

Universidade de Coimbra, Portugal

Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Unidade de Investigação e Desenvolvimento Química-Física Molecular, Portugal

Universidade Federal de Pernambuco, Brazil

Universidade do Porto Faculdade de Farmácia, Portugal

Universidade Federal de Juiz de Fora, Brazil
Fundação para a Ciência e a Tecnologia
Concluded
2007/11/01 - 2010/04/30 Influence of Cell Differentiation State on Apoptosis Induced by Isoproterenol on Embryonic Ventricular H9c2 Cells: Signaling Pathways Involved
PTDC/QUI/64358/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/11 - 2010/04 Influence of Cell Differentiation State on Apoptosis Induced by Isoproterenol on Embryonic Ventricular H9c2 Cells - Signalling Pathways Involved
grant.Provided by PTCRIS: 64358
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2007/09/15 - 2010/03/13 Novel Mitochondrial Mechanisms for the Cardioselective Toxicity of Doxorubicin
PTDC/SAU-OSM/64084/2006
Universidade do Porto Centro de Investigação em Actividade Física Saúde e Lazer, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/09/15 - 2010/03/13 Novos Mecanismos Mitocondriais Para a Toxicidade Cardioselectiva da Doxorubicina
PTDC/SAU-OSM/64084/2006
Universidade do Porto Centro de Investigação em Actividade Física Saúde e Lazer, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Santos-Carvalho, Ana; Silva, Ana Maria; Deus, Cláudia; Pereira, Susana; Oliveira, Teresa; Sardão, Vilma; Oliveira, Paulo; Ferreira, Sónia. Curso Avançado de Biomedicina: mitocôndria e doenças, 10º, 11º e 12º anos. Mamarrosa, Portugal: IEC. 2015.
    Published
  2. Sardão, V.; Rose-Hellekant, T.; Perkins, E.; Greene, A.; Holy, J.. Measuring reciprocal regulation of mesenchymal stem cell and tumor cell motility in two and three dimensions in vitro. 2010.
Book chapter
  1. Cláudia M. Deus; Branco, Ana; Paulo J. Oliveira; Sardão, Vilma. "Coffee in Health and Disease Prevention, Second Edition. Accepted for publication". The Netherlands: Elsevier, 2024.
    Accepted
  2. Simões, Rui F.; Cunha-Oliveira, Teresa; Costa, Cláudio F.; Sardão, Vilma A.; Oliveira, Paulo J.. "In Vitro Methodologies to Investigate Drug-Induced Toxicities". In Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants, edited by Yvonne Will; James A. Dykens, 229-247. John Wiley & Sons, Inc., 2018.
    Published • 10.1002/9781119329725.ch14
  3. Vega-Naredo, I.; Cunha-Oliveira, T.; Serafim, T.L.; Sardao, V.A.; Oliveira, P.J.. "Analysis of pro-apoptotic protein trafficking to and from mitochondria". 2015.
    10.1007/978-1-4939-1875-1_14
  4. Deus, Cláudia; Branco, Ana F.; Oliveira, Paulo J.; Sardão, Vilma. "Caffeine Cardiovascular Toxicity". In Coffee in Health and Disease Prevention, 699-707. Elsevier, 2015.
    10.1016/b978-0-12-409517-5.00078-4
  5. Deus, C.; Branco, A.F.; Oliveira, P.J.; Sardão, V.. "Caffeine Cardiovascular Toxicity: Too Much of a Good Thing". 2014.
    10.1016/B978-0-12-409517-5.00078-4
  6. Videira, Romeu; Ana M Silva; Sardão, Vilma; Oliveira, Maria Manuel; Peixoto, Francisco; Jurado, Amália S.. "Insecticide interactions with biological membranes: From membrane partition to biophysical effects.". In A Toxicological/Pharmacological Approach to Chemico-Biological Interactions at a Membrane Level, 71-92. India: Research Signpost, 2012.
    Published
  7. Moreira, Ana C; Machado, Nuno G; Bernardo, Telma; Sardão, Vilma; Oliveira, Paulo J. "Mitochondria as a Biosensor for Drug-induced Toxicity – Is It Really Relevant?". In In Biosensors for Health, Environment and Biosecurity - Book 2, edited by Pier Andrea Serra. In Tech, 2011.
    Published
  8. Oliveira, P.J.; Sardão, V.A.; Wallace, K.B.. "Cardiovascular Toxicity of Mitochondrial Origin". 2008.
    10.1002/9780470372531.ch6
  9. Sardão, Vilma; Santos, Dario L.; Oliveira, P. J.. "Cardiac Mitochondrial Dysfunction Induced by Doxorubicin: Role of Calcium and Oxidative Stress.". In Mitochondrial Pharmacology and Toxicology, edited by Moreno, António J. M.; Oliveira, P. J.; Palmeira, Carlos M.. Research Signpost, 2006.
Conference abstract
  1. Magalhães, Carina; Amorim, Ricardo; Benfeito, Sofia ; Fernando Caride; Ludgero Tavares; Sardão, Vilma; Jones, John; et al. "Repurposing the effects of decyl-TPP mitochondriotropic caffeic acid antioxidant AntiOxCIN6: The impact of rewiring mitochondrial metabolism on cisplatin anticancer therapy". Paper presented in 58th Annual Meeting of the European Society for Clinical Investigation, Barcelona, 2024.
  2. Pedrosa, Ana; Soares, Carlos; Pinho, Ana Sofia; Sousa-e-Silva, P; Filipe, P; Azul,T; Oliveira, PJ; et al. "The Effect of LifeLong Exercise on the Mitochondrial Respiratory Chain Function in Human Peripheral Blood Mononuclear Cells.". Paper presented in 57TH ANNUAL SCIENTIFIC MEETING " Envisioning the future of Clinical and Experimental Investigation in Europe and Beyond" – 7–9 June 2023, Prague, Czech Republic, Prague, 2023.
    Published • https://doi.org/10.1111/eci.13990
  3. Vieira-Pedrosa, A.; Soares, C. ; Alves, J.; Rosado, F.; Fonseca, V.; Sardão, Vilma; Rama, L.; Teixeira, M. A. "The effect of lifelong sports training on mitochondrial function: the impact of acute exercise". Paper presented in The 15th Symposium of the International Society of Exercise and Immunology (ISEI), Tucson, 2022.
  4. Luis Monteiro; Patricia Pitrez; S. Correia Santos ; Sardão, Vilma; Francisco, Vitor; Cortes, Luisa; Ferreira, Lino. "Cardiovascular & metabolic diseases modeling of ageing in human cardiomyocytes derived from induced pluripotent stem cells". Paper presented in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Bari, 2022.
    Published
  5. Luis Monteiro; Pitrez, Patricia R.; N Dark; Deolinda Santinha; Xavier, Nissan; Sardão, Vilma; Francisco, Vitor; et al. "Modeling and drug screening on human cardiomyocytes derived from hutchinson-gilford progeria syndrome induced pluripotent stem cells". Paper presented in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Bari, 2022.
    Published
  6. Melim, Catarina; Teixeira, José; Varela, Carla; Marques, Mário; Sardão, Vilma; Oliveira, Paulo; Célia Cabral. "Potential of Côa Valley (Portugal) Plants Extracts in Cell Model for Hepatic Lipid Toxicity". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), Bari, 2022.
    Published
  7. Fonseca, Élisa; Novo, João Pedro; Corte Real Martins, Beatriz; Raposo, Ramon; Sardão, Vilma; Oliveira, Paulo; Pereira, Frederico; et al. "BV-2 Microglial cell death induced by acute exposure to Methylmercury". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI 2022), Bari, 2022.
    Submitted
  8. Castelão-Baptista, José P.; OPPOLZER, D.; Carlos Venâncio; Martins, T; Antunes, L; Rosa, Eduardo; OLIVEIRA, PJ.; Sardão, Vilma. "Phytochemical composition of broccoli inflorescences, stalks and leaves: comparative study as a resource of bioactive compounds for human diet.". Paper presented in IberPhenol - International Virtual Conference - Advances in the role of phenols in health effects and other uses, 2020.
    Published
  9. Ana Maria Silva; Romeu A. Videira; Ana C. Moreira; Paulo J. Oliveira; Rui A. Carvalho; Sardão, Vilma. "Delving the Bone-buried Osteocytes lipid metabolism commitment in post-menopausal osteoporosis.". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, Coimbra, 2019.
    Published
  10. Guida Bento; Sardão, Vilma; Paula M. Macedo; Paulo J. Oliveira. "Metabolic fluxes of human urine-derived cells are comparable in young and old donors.". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, Coimbra, 2019.
    Published
  11. Margarida R. Silva; Ricardo Marques; Bárbara Sousa; Sardão, Vilma; Paulo J. Oliveira; Joana Paredes. "P-cadherin effect in mitochondrial dynamics and biogenesis of breast cancer cells.". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, Coimbra, 2019.
  12. Canário, Sara; Carvalho, Adriana; Valente, Sara; Sardão, Vilma. "Role of estrogen on metabolic remodeling during osteoclast differentiation". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, Coimbra, 2019.
    Published
  13. Carvalho, Adriana; Canário, Sara; Valente, Sara; Sardão, Vilma. "Mitochondria performance during rankl-induced osteoclast differentiation". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, Coimbra, 2019.
    Published
  14. Valente, Sara; Marques-Carvalho, Adriana; Canário, Sara; Sardão, Vilma. "How estrogen modulates mitochondrial function during osteoblast differentiation?". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, Coimbra, 2019.
    Published
  15. Guida Bento; Paulo J. Oliveira; Paula M. Macedo; Sardão, Vilma. "Human urine-derived cells for assessing metabolic profile and mitochondrial morphology in young and old donors". Paper presented in 52nd Annual Meeting of the European Society for Clinical Investigation, Barcelona, 2018.
    Published
  16. Vecchione, G.; Grasselli, E.; Oliveira, P. J.; Sardao, V. A.; Cioffi, F.; Baldini, F.; Cortese, K.; et al. "Silybin-vitamin E phytosome complex counteracts lipid excess and oxidative stress in an in vitro model of non alcoholic steatohepatitis (NASH)". Paper presented in 51th Annual Meeting of the European Society for Clinical Investigation, Genova, 2017.
  17. Bento, G.; Oliveira, P. J.; Sardao, V. A.. "A protocol for human urine-derived stem cells isolation, expansion, and mitochondrial function profile analysis". Paper presented in 51th Annual Meeting of the European Society for Clinical Investigation, Genova, 2017.
    Accepted
  18. Grasselli, E.; Demori, I.; Vecchione, G.; Oliveira, P. J.; Sardao, V. A.; Baldini, F.; Voci, A.; Portincasa, P.; Vergani, L.. "A novel cellular model to study the combined actions of fructose and fatty acids in inducing a steatohepatitis condition". Paper presented in 51th Annual Meeting of the European Society for Clinical Investigation, Genova, 2017.
  19. Serafim, T. L.; Cunha-Oliveira, T.; Sardao, V. A.; Deus, C. M.; Cardoso, I.; Pinho, S.; Yang, S.; et al. "Maternal obesity (MO) in sheep decreases fetal hepatic mitochondrial respiratory chain activity and total mitochondrial lipids". Paper presented in 51th Annual Meeting of the European Society for Clinical Investigation, Genova, 2017.
    Published
  20. Wojtala, A.; Lebiedzinska-Arciszewska, M.; Jezdrak, P.; Sardao, V. A.; Wegrzyn, G.; Pronicki, M.; Pinton, P.; et al. "Characterisation of the mitochondrial bioenergetic, ROS and status of antioxidant defence system profiles in fibroblasts of patients showing mitochondrial abnormalities". Paper presented in 51th Annual Meeting of the European Society for Clinical Investigation, Genova, 2017.
    Published
  21. Teixeira, J. C.; Amorim, R.; Santos, K.; Soares, P.; Serafim, T.; Sardao, V.; Garrido, J.; Borges, F.; Oliveira, P.. "MitoK3, a novel mitochondriotropic menadione derivative with cytotoxic effects on cancer cells". Paper presented in 51th Annual Meeting of the European Society for Clinical Investigation, Genova, 2017.
    Published
  22. Sardao, V. A.; Silva, T. B.; Simoes, R. F.; Oliveira, P. J.; Veloso, C. D.; Valente, M. J.; Silva, R. S.; Remiao, F.; Borges, F.. "Promising new catechol O-methyltransferase (COMT) inhibitors for Parkinson's disease display lower mitochondrial toxicity". Paper presented in 51th Annual Meeting of the European Society for Clinical Investigation, Genova, 2017.
    Published
  23. Silva, T.; Simoes, R. F.; Sardao, V.; Oliveira, P. J.; Valente, M. J.; Silva, R.; Remiao, F.; Borges, F.. "In vitro cellular and mitochondrial toxicity of tolcapone and related nitrocatechols". 2016.
    10.1016/j.toxlet.2016.06.1517
  24. Ana M Silva; Moreira, Ana C.; Santos, Maria Sancha; Dias, Juliana; Alves, Nuno M; Videira, Romeu; Carvalho, RA; Carvalho, R; Carvalho Rui; Sardão, Vilma. "Estradiol modulates and recovers osteocyte metabolic/lipid profiles after ovariectomy in acute and long-term in vivo hormone replacement therapeutics". Paper presented in 4th Joint Meeting of ECTS and IBMS, Rotterdam, 2015.
    Published
  25. Ana M Silva; Moreira, Ana C.; Santos, M Sancha; Albuquerque, Anabela; Ferreira, Isilda; Gil, Paulo; Videira, Romeu; Carvalho, RA; Carvalho, R; Carvalho Rui; Sardão, Vilma. "24h hormone replacement therapy induced relevant osteocyte metabolic remodeling in a post-menopausal osteoporosis rat model". Paper presented in XVIII Congress of Portuguese Society of Biochemistry, Coimbra, 2014.
  26. Ana M Silva; Moreira, Ana C.; Santos, M Sancha; Albuquerque, Anabela; Videira, Romeu; Carvalho, RA; Carvalho, R; Carvalho Rui; Sardão, Vilma. "Post-menopausal bone loss and Estrogen decline: Is metabolic shift at osteocytes level that rules on it?". Paper presented in XII CNC Annual Meeting, Coimbra, 2014.
  27. Couto, Renata; Sardão, Vilma; Oliveira, Paulo J. "Protection Provided by Phytoestrogens against Cardiac Lipotoxicity induced by Palmitic Acid". Paper presented in European Society for Clinical Investigation (ESCI) Annual scientific meeting, Utrecht, 2014.
    10.1111/eci.12258
  28. Moreira, Ana C.; Ana M Silva; Santos, Maria Sancha; Sardão, Vilma. "Resveratol Affects Mitochondrial Bioenergetics in Brain and Liver: A Possible Caution for its use against Menopause symptoms.". Paper presented in 47th Annual Meeting of the European Society of Clinical Investigation, Albufeira, 2013.
  29. Ana M Silva; Moreira, Ana C.; Santos, Maria Sancha; Videira, Romeu; Carvalho, RA; Carvalho, R; Carvalho Rui; Sardão, Vilma. "Post-menopausal bone loss: comparison of the metabolic profiles of bone-embedded osteocytes in normal and ovariectomized female rats.". Paper presented in 47th Annual Meeting of the European Society of Clinical Investigation, Albufeira, 2013.
  30. Ana M Silva; Moreira, Ana C.; Santos, Maria Sancha; Videira, Romeu; Carvalho, RA; Carvalho, R; Carvalho Rui; Sardão, Vilma. "Understanding bone lipidomics of mineral bone cells in normal and estrogen-deprived animals.". Paper presented in 47th Annual Meeting of the European Society of Clinical Investigation, 2013.
  31. Moreira, Ana C.; Ana M Silva; Wolf, Andrea; Soldner, Emma; Pereira, Gonçalo C.; Hartz, Anika; Bauer, Bjoern; Santos, Maria Sancha; Sardão, Vilma. "Phytoestrogens as alternative to the hormone replacement therapy". Paper presented in 47th Annual Meeting of the European Society of Clinical Investigation, Albufeira, 2013.
  32. Moreira, Ana C.; Ana M Silva; Wolf, Andrea; Soldner, Emma; Pereira, Gonçalo; Hartz, Anika; Bauer, Bjoern; Santos, Maria Sancha; Sardão, Vilma. "Coumestrol as safe and valid alternative for the hormone replacement therapy". Paper presented in X Annual Meeting of Center for Neuroscience and Cell Biology,, Cantanhede, 2012.
  33. Moreira, Ana C.; Ana M Silva; Oliveira, Paulo; Santos, Maria Sancha; Holy, John; Sardão, Vilma. "Estrogen Dependent Effects on Breast Cancer Cell Motility and Proliferation". Paper presented in XLI Annual Meeting of the Portuguese Society of Pharmacology, Coimbra, 2011.
  34. Sardão, Vilma; Paulo J. Oliveira; Pedro Monteiro; Lino Gonçalves; Luís Providência; António J. M. Moreno. "A Cafeína Induz Directamente a Transição de Permeabilidade em Mitocôndrias Isoladas de Coração de Rato". Paper presented in XXII Congresso Português de Cardiologia, Vilamoura, 2001.
    Published
Conference poster
  1. Coelho, Patrícia; Sardão, Vilma; Raimundo, Nuno. "Mitochondrial complex I deficiency perturbs peroxisomal biogenesis and function". Paper presented in 48th FEBS Congress, 2024.
  2. Coelho, Patrícia; Sardão, Vilma; Raimundo, Nuno. "Mitochondrial respiratory complex I deficiency alters peroxissomal biogenesis". Paper presented in RESETAgeing 2023, 2023.
  3. Adriana Marques-Carvalho; Weng Ling; Kim Richardson; Aaron Warren; Sardão, Vilma; Maria Almeida; Ha-Neui Kim. "Estrogens Inhibit Bone Resorption by Decreasing NAD+/NADH Redox Levels and the Activity of the Mitochondria Deacetylase Sirt3 in Osteoclasts.". Paper presented in American Society for Bone and Mineral Research Annual Meeting, 2022.
  4. Adriana Marques-Carvalho; Aaron Warren; Sardão, Vilma; Ha-Neui Kim; Maria Almeida. Corresponding author: Maria Almeida. "Conserved Signaling Intermediate in Toll Pathway (ECSIT) is indispensable for RANKL-induced mitochondria stimulation and a target of the anti-osteoclastogenic effects of estrogens.". Paper presented in American Society for Bone and Mineral Research Annual Meeting, 2022.
  5. Ilina, V.; Teixeira, J.; Varela, Carla; Marques, M.; Sardão, Vilma; Melim, C. ; Baranenko, D. ; Oliveira, P. E41F-4FB7-5948; Cabral, C. "In Vitro Cardioprotective Potential of Côa Valley (Portugal) Plants Extracts Against Lipotoxic Insults". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2022.
  6. Adriana Marques-Carvalho; Ha-Neui Kim; Sardão, Vilma; Maria Almeida. "E2 inhibits bone resorption by impacting the NAD/NADH redox state and decreasing the activity of the mitochondria deacetylase Sirt3". Paper presented in 56th Annual Meeting of the European Society for Clinical Investigation, 2022.
  7. Adriana Marques-Carvalho; Ha-Neui Kim; Sardão, Vilma; Maria Almeida. "ECSIT is essential for RANKL-induced stimulation of mitochondria and a target for the anti-­osteoclastogenic effects of estrogens". Paper presented in 56th Annual Meeting of the European Society for Clinical Investigation, 2022.
  8. Monteiro, Luís; Pitrez, Patricia R.; Correia-Santos, Simão; Nicola Dark; Deolinda Santinha; Xavier, Nissan; Sardão, Vilma; et al. Corresponding author: Monteiro, Luís. "Disease modeling and drug screening on cardiomyocytes derived from Hutchinson-Gilford Progeria Syndrome- induced pluripotent stem cells". Paper presented in The Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2022.
  9. Adriana Marques-Carvalho; Beatriz Silva; Francisco Pereira; Ha-Neui Kim; Paulo Oliveira; Maria Almeida; Sardão, Vilma. "Estrogens inhibit metabolic reprogramming of early osteoclast precursors and promote mitochondria-induced apoptotic death". Paper presented in American Society for Bone and Mineral Research Annual Meeting., 2021.
  10. Silva, Filomena S.G.; Cunha-Oliveira, Teresa; Débora, Mena; Sardão, Vilma; Duarte, Ana I.; Oliveira, Paulo J. "Unraveling glycolic pathways on amyotrophic lateral sclerosis patients presenting mutant SOD1 or unknown mutations.". Paper presented in AD/PD 2021: 15th International Conference on Alzheimer‘s & Parkinson‘s Diseases, 2021.
  11. Adriana Marques-Carvalho; Ha-Neui Kim; Maria Almeida; Sardão, Vilma. "Estrogens inhibit RANKL-induced early stimulation of complex I and mitochondria function in osteoclast progenitors". Paper presented in ESCI Virtual Meeting 2020 - Covid19 Edition, 2020.
  12. Marques, R; Julieta Afonso; Barbosa Matos C; Michaelis M; Longatto, Adhemar; Cinatl JrJ; Sardão, Vilma; Baltazar F. "Metabolic remodelling in cisplatin-resistant bladder cancer". Paper presented in EACR-AACR-ASPIC Conference on Tumor Microenvironment, 2020.
  13. Marques, R; Serafim, Teresa; Deus CM; Silva, F.S.G.; Sardão, Vilma; Dias, Sérgio; Oliveira, Paulo. "Glucose dependence and metabolic reprogramming of commercial breast cancer cells.". Paper presented in EACR-AACR-ASPIC Conference on Tumor Microenvironment, 2020.
  14. Marques, R; Sousa, Bárbara; Sardão, Vilma; Schmitt, F.; Oliveira, Paulo; Paredes, Joana. "P-cadherin induces anoikis resistance in breast cancer stem cells by rewiring the metabolic flux and activating of antioxidant systems". Paper presented in 2nd FEBS 2019 Advanced Course on. Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019.
  15. Marques, R; Deus C; Silva, F.S.G.; Sardão, Vilma; Oliveira, Paulo; Serafim, Teresa. "Metabolic reprogramming forwards oxidative phosphorylation in breast cancer cells as potential drug targets". Paper presented in 2nd FEBS 2019 Advanced Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019.
  16. Adriana Marques-Carvalho; Sara Canário; Sara Valente; Sardão, Vilma. "Mitochondria Performance During RANKL-induced Osteoclast Differentiation.". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, 2019.
  17. Sara Canário; Adriana Marques-Carvalho; Sara Valente; Sardão, Vilma. "Role of Estrogen on Metabolic Remodeling during osteoclast differentiation.". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, 2019.
  18. Sara Valente; Adriana Marques-Carvalho; Sara Canário; Sardão, Vilma. "How estrogen modulates mitochondrial function during osteoblast differentiation?". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, 2019.
  19. Margarida R. Silva; Ricardo J Marques; Barbara Sousa; Sardão, Vilma; Paulo J. Oliveira; Joana Paredes. "P-cadherin effect in mitochondrial dynamics and biogenesis of breast cancer cells.". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, 2019.
  20. Guida Bento; Sardão, Vilma; Maria Paula Macedo; Paulo J. Oliveira. "Metabolic fluxes of human urine-derived cells are comparable in young and old donors". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, 2019.
  21. Sara Valente; Sara Canário; Adriana Marques-Carvalho; Sardão, Vilma. "MitoBoneLomics: Estradiol remodeling effect on mitochondrial activity during osteoblast differentiation.". Paper presented in 46th European Calcified Tissue Society Congress, 2019.
  22. Marques, R; Afonso J,; Barbosa-Matos C; Michaelis M; Longatto A; Santos L,; Cinatl JrJ; Sardão, Vilma; Baltazar F. "Cisplatin-resistant urothelial bladder cancer cells undergo metabolic reprogramming". Paper presented in Porto Cancer Meeting, 2019.
  23. Bárbara Sousa; Joana Pereira; Ana Rita Nobre; Ricardo Marques; Patricia Carneiro; Sardão, Vilma; Paulo J. Oliveira; Joana Paredes. "P-cadherin promotes anoikis resistance in breast cancer stem cells by stimulating the glycolytic behavior and lowering the oxidative stress". Paper presented in 7th I3S Scientific Retreat - IBMC/INEB/IPATIMUP, 2018.
  24. Carvalho, Adriana; Canário, Sara; Valente, Sara; Sardão, Vilma. "Mitochondria Performance During Osteoclast Differentiation – Exploring New Targets for Bone Disease Therapies.". Paper presented in 9th World Congress on Tergeting Mitochondria, Berlin, Germany,, 2018.
  25. Carvalho, Adriana; Sardão, Vilma. "Metabolic remodeling during RANKL-induced osteoclast differentiation.". Paper presented in MitoPorto – Mitochondrial evolution, metabolism and diseases, International symposium, University of Porto, Portugal,, 2018.
  26. Bento, Guida; Oliveira, Paulo; Macedo, Maria; Sardão, Vilma. "Human urine-derived cells from young and old donors for assessing glycolytic and oxidative phosphorylation functions.". Paper presented in MitoPorto – Mitochondrial evolution, metabolism and diseases, International symposium, University of Porto, Portugal,, 2018.
  27. Marques-Carvalho, Adriana; Sardão, Vilma. "Mitochondrial alterations during OC differentiation". Paper presented in MitoPorto, 2018.
  28. Marques, R; Sousa, B.; Pereira, J.; Nobre AR; Carneiro P,; Sardão, Vilma; Schmitt, F.; Oliveira, Paulo; Paredes, Joana. "P- Cadherin promotes anoikis resistance in breast cancer stem cells by stimulating the glycolytic behavior and lowering the oxidative". Paper presented in 3rd ASPIC International congress, 2018.
  29. Teixeira, Jose; Amorim, Ricardo; Santos, Katia; Sardão, Vilma; Soares, Pedro; Serafim, Teresa; Garrido, Jorge; Oliveira, Paulo; Borges, Fernanda. "In vitro characterization of potential biological applications of MITOK3, A NOVEL Mitocondriotropic Menadione derivative, EpiChemBio (CM1406) and MuTaLig (CA15135)". Paper presented in COST actions joint meeting 2017, Porto, Portugal,, 2017.
  30. Sardão, Vilma; Bento, Guida; Oliveira, Paulo. "Mitochondrial bioenergetic profile of human urine-derived stem cells.". Paper presented in MitoPorto – Advances in mitochondrial research, International symposium, University of Porto, Portugal, 2017.
  31. Teixeira, Jose; Amorim, Ricardo; Santos, Katia; Soares, Pedro; Sardão, Vilma; Serafim, Teresa; Garrido, Jorge; Borges, Fernanda; Oliveira, Paulo. "Improvement of menadione cytotoxic potential by a mitochondria-targeted strategy.". Paper presented in MitoPorto: Advances in Mitochondrial Research International Symposium, University of Porto, Portugal, 2017.
  32. Costa, Cláudio; Maleita, Joana; Deus, Cláudia M.; Pereira, Susana P; Serafim, Teresa; Sardão, Vilma; Oliveira, Paulo; Cunha-Oliveira, Teresa. "Characterization of mitochondrial parameters in cell lines in the presence or absence of glucose. Bioenergetic Analysis: establishment and characterization of new models.". Paper presented in MitoPorto - Advances in Mitochondrial Research, University of Porto, Portugal,, 2017.
  33. Serafim, Teresa; Pinho, Sónia; Martins, Tatiana R; Sardão, Vilma; Grilo, Luís F.; Cavallaro, Chiara H.; Yang, Shanshan; et al. "Impact of Maternal Obesity During Pregnancy on Fetal Hepatic Redox Profile and Quality Control Proteins.". Paper presented in MitoPorto - Advances in Mitochondrial Research, Porto, Portugal. University of Porto, Portugal, 2017.
  34. Serafim, Teresa; Deus, Cláudia M.; Cunha-Oliveira, Teresa; Sardão, Vilma; Cunha, Pedro; Veloso, Caroline; Costa, Daniela; et al. "Stimulation of mitochondrial metabolism in human breast cancer cells results in increased cell motility and decreased resistance to metabolic inhibitors.". Paper presented in MitoPorto - Advances in mitochondrial research, International Symposium, Porto, University of Porto, Portugal, 2017.
  35. Sardão, Vilma; Silva, Tiago B.; Simões, Rui; Oliveira, Paulo; Veloso, Caroline; Valente, Maria J.; Silva, Renata S.; Remião, Fernando; Borges, Fernanda. "Parkinson’s disease therapy with improved Catechol O-Methyltransferase (COMT) inhibitors display lower mitochondrial liabilities.". Paper presented in MitoPorto - Advances in mitochondrial research. International symposium, University of Porto, Portugal, 2017.
  36. Sardão, Vilma; Silva, T.B.; Simões, Rui F.; Oliveira, Paulo; Veloso, Caroline; Valente, M.J.; Silva, R.S.; Remião, Fernando; Borges, Fernanda. "Parkinson’s disease therapy with improved Catechol O-Methyltransferase (COMT) inhibitors display lower mitochondrial liabilitie". Paper presented in MitoPorto - Advances in mitochondrial research. International symposium, 2017.
  37. Bento, Guida; Oliveira, Paulo; Sardão, Vilma. "A Protocol for Human Urine-derived Stem Cells Isolation, Expansion, and Mitochondrial Function Profile Analysis.". Paper presented in 51th Annual Meeting of the European Society for Clinical Investigation, Genoa, Italy, 2017.
  38. João Campos; Pereira, Francisco; Ernesto Costa; Sardão, Vilma; Teresa Cunha-Oliveira; Tiago Silva; Rui Simões; et al. "Extracting Knowledge from Data to Predict Mitochondrial Toxicity Indexes for Pharmacological Compounds". Paper presented in MitoPorto International Symposium, Porto, Portugal, 2017 2017, 2017.
  39. Sardão, Vilma; Silva, Tiago B.,; Simões, Rui; Oliveira, Paulo; Vamente, Maria J.; Silva, Renata S.; Remião, Fernando; Borges, Fernanda. "Developing a Novel Generation of Catechol O-Methyltransferase (COMT) Inhibitors Without Mitochondrial Liabilities for the Therapy of Parkinson’s Disase". Paper presented in 7th World Congress on Tergeting Mitochondria, 2016.
  40. Silva, Ana M.; Sardão, Vilma. "Toxicity and Metabolic Evaluation of Estradiol, Coumestrol and Resveratrol on osteoblast-like MLO-A5 and osteocyte-like MLO-Y4 cell lines.". Paper presented in 4th Joint Meeting of ECTS and IBMS, 2015.
  41. Serafim, Teresa; Teresa Cunha-Oliveira; Sardão, Vilma; Deus, Cláudia M.; Greene, Amy; Perkins, Edward; Oliveira, Paulo. "Characterization of Mitochondria of Breast Cancer Cell Lines.". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  42. Couto, Renata; Sardão, Vilma. "Protective Effects of Phytoestrogens on Cardiac Lipotoxicity Induced by Palmitic Acid.". Paper presented in XVIII Congress of the Portuguese Biochemical, 2014.
  43. Couto, Renata; Sardão, Vilma. "Protection provided by phytoestrogens on cardiac lipotoxicity induced by palmitic acid.". Paper presented in 48th Annual Meeting of the European Society for Clinical Investigation, in Utrecht, The Netherlands,, 2014.
  44. Ana M Silva; Moreira, Ana C.; Santos, Maria Sancha; Videira, Romeu; Carvalho, RA; Carvalho, R; Carvalho Rui; Sardão, Vilma. "Lipidomic of Bone Mineral Cells in normal and estrogen-deprived Animals: Role of acute hormone replacement therapeutics with Estradiol and Coumestrol". Paper presented in Oxygen Club of California – World Congress, 2013.
  45. Sardão, Vilma; Silva, Ana Maria; Moreira, Ana C.; Santos, Maria S.; Videira, Romeu; Carvalho, Rui. "Lipidomics of mineral bone cells in normal and estrogen-deprived animals: Role of acute hormone-replacement therapeutics with estradiol and coumestrol". Paper presented in 5th International Symposium on Nutrition, Oxygen Biology & Medicine, in Paris, France, 2013.
  46. Ana M Silva; Moreira, Ana C.; Santos, Maria Sancha; Albuquerque, Anabela; Ferreira, Isilda; Gil, Paulo; Videira, Romeu; Carvalho, RA; Carvalho, R; Carvalho Rui; Sardão, Vilma. "Osteocyte metabolism on post-menopausal bone loss and role of hormone replacement therapy". Paper presented in European Calcified Tissue Society Congres, 2013.
  47. Silva, Ana Maria; Moreira, Ana C.; Santos, Maria Sancha; Videira, Romeu; Carvalho, Rui; Sardão, Vilma. "Understanding bone lipidomics of mineral bone cells in normal and estrogens-deprived animals". Paper presented in 47th Annual Meeting of the European Society for Clinical Investigation (ESCI), Albufeira, Portugal, 2013.
  48. Moreira, Ana C.; Silva, Ana M.; Santos, Maria S.; Sardão, Vilma. "Resveratrol affects mitochondrial bioenergetics in brain and liver: a possible caution for its use against menopause symptoms". Paper presented in 47th Annual Meeting of the European Society for Clinical Investigation (ESCI), Albufeira, Portugal, 2013.
  49. Branco, Ana F.; Sampaio, Susana F.; Sardão, Vilma; Gonzales, Susana; Oliveira, Paulo. "Isoproterenol-induced toxicity on H9c2 myoblasts depends on the differentiation status". Paper presented in 47th Annual Meeting of the European Society for Clinical Investigation, Albufeira, Portugal April 17-20, 2013, 2013.
  50. Serafim, Teresa; Sardão, Vilma; Greene, Amy; Perkins, Edward; Santos, Maria S.; Oliveira, Paulo. "Profilling mitochondrial physiology in commercial human cancer cell line for evaluating coumpound anticancer activity". Paper presented in 47th Annual Meeting of the European Society for Clinical Investigation, Albufeira, Portugal, 2013.
  51. Moreira, Ana C.; Wolf, Andrea; Soldner, Emma L. B.; Santos, Maria S.; Sardão, Vilma; Bauer, Björn; Hartz, Anika M. S.. "Modulation of GLUT-1 expression at the Blood-Brain Barrier by Estrogens". Paper presented in Beating the Blood-Brain and other Blood Barriers, Lisbon, Portugal, 2013.
  52. Sardão, Vilma. "Enterodiol Protects H9C2 Cardiomyoblasts From Palmitic Acid-Induced Lipotoxicity: Relevance for Hormone Replacement Therapy During Menopause". Paper presented in 3rd World Congress on Targeting Mitochondria, Berlin, German, 2012.
  53. Silva, Ana M.; Moreira, Ana C.; Santos, Maria S.; Sardão, Vilma. "Gender-Dependent Rat Liver and Brain Mitochondrial Antioxidant Defenses". Paper presented in OCC conferences: Oxidants and Antioxidants in Biology – Cell Signaling and Nutrient-Gene Interactions, Alba, Italy, 2012.
  54. Sampaio, Susana; Moreira, Ana C.; Branco, Ana; Santos, Maria S.; Oliveira, Paulo; Sardão, Vilma. "Apoptosis-inducing Factor (AIF) Role in Anthracycline-Induced Cardiomyoblast Cell Death". Paper presented in OCC conferences: Oxidants and Antioxidants in Biology – Cell Signaling and Nutrient-Gene Interactions, Alba, Italy,, 2012.
  55. Moreira, Ana C.; Silva, Ana Maria; Santos, Maria S.; Sardão, Vilma. "Organ and gender-dependent mitochondrial antioxidante modulation by resveratrol,". Paper presented in OCC conferences: Oxidants and Antioxidants in Biology – Cell Signaling and Nutrient-Gene Interactions, Alba, Italy,, 2012.
  56. Moreira, Ana C.; Wolf, Andrea; Soldner, Emma L.B.; Santos, Maria S.; Sardão, Vilma; Hartz, Anika M. S.; Bauer, Björn. "Modulation of GLUT-1 Expression at Blood-Brain Barrier by Estrogens: a Mechanism to overcome Hot Flashes in Menopause". Paper presented in Gordon Research Conference, Barriers of CNS, New London, NH, USA, 2012.
  57. Moreira, Ana C.; Ana M Silva; Santos, Maria Sancha; Sardão, Vilma. "Organ and gender-dependent mitochondrial antioxidant modulation by resveratrol". Paper presented in Oxygen Club of California – World Congress, 2012.
  58. Sampaio, Susana; Moreira, Ana C.; Santos, Maria S.; Oliveira, Paulo; Sardão, Vilma. "Role of the Apoptosis-inducing Factor (AIF) on Doxorubicin-induced Cardiomyoblast Cell Death". Paper presented in 6th National Meeting on Cell Signaling, Braga, Portugal, 2012.
  59. Moreira, Ana C.; Silva, Ana M; Holy, Jon; Santos, Maria S.; Sardão, Vilma. "Differences in Breast Cell Proliferation and motility in the presence or absence of Estrogens and Phytoestrogens". Paper presented in 9th European Congress on Menopause and Andropause, Athens, Greece, 2012.
  60. Silva, Ana M.; Moreira, Ana C.; Santos, Maria S.; Sardão, Vilma. "Resveratrol in Liver Mitochondria: Beyond its antioxidant role". Paper presented in 46th Annual Scientific Meeting of the European Society for Clinical Investigation, Budapest, Hungary, 2012.
  61. Silva, Ana M.; Oliveira, Paulo; Moreira, Ana C.; Santos, Maria S.; Sardão, Vilma. "Are phytoestrogens able to prevent lipotoxicity in cardiac cells?". Paper presented in 46th Annual Scientific Meeting of the European Society for Clinical Investigation, Budapest, Hungary, 2012.
  62. Moreira, Ana C.; Silva, Ana M.; Holy, Jon; Santos, Maria S.; Sardão, Vilma. "Effects of estrogens and phytoestrogens in breast cell proliferation and motility.". Paper presented in 46th Annual Scientific Meeting of the European Society for Clinical Investigation, Budapest, Hungary,, 2012.
  63. Moreira, Ana C.; Ana M Silva; Santos, Maria Sancha; Sardão, Vilma. "Effects of Estrogens and Phytoestrogens in Breast Cancer Proliferation and Motility". Paper presented in 46th Congress of European Society for Clinical Investigation, 2012.
  64. Serafim, Teresa; Sardão, Vilma; Greene, Amy; Perkins, Edward; Santos, Maria S.; Oliveira, Paulo. "Mitochondrial characterization of breast cancer cell lines for chemotherapeutic in vitro studies.". Paper presented in AACR Special Conference: Metabolism and Cancer, Baltimore, USA, 2011.
  65. Moreira, Ana C.; Silva, Ana M.; Alves, Estela; Santos, Maria S.; Sardão, Vilma. "Toxicity and antioxidant capacity of resveratrol on liver and brain mitochondria – are there gender-dependent effects?". Paper presented in Mitochondrial Physiology and Medicine, Woods Hole, Massachusetts, USA,, 2011.
  66. Moreira, Ana C.; Silva, Ana M.; Alves, Estela; Santos, Maria S.; Sardão, Vilma. "Are Phytoestrogens a Safe Alternative to Hormone Replacement Therapy? A toxicological study". Paper presented in 45th Annual Scientific Meeting of the European Society for Clinical Investigation, Crete, Greece, 2011.
  67. Silva, Ana M.; Moreira, Ana C.; Alves, Estela; Santos, Maria S.; Sardão, Vilma. "Comparative liver mitochondria toxicity of phytoestrogens: effects as a matter of gender?". Paper presented in 17th National Congress of Biochemistry, Porto, Portugal, 2010.
  68. Moreira, Ana C.; Silva, Ana M.; Alves, Estela; Santos, Maria S.; Sardão, Vilma. "Mitochondrial and Antioxidant Effects of Selected Phytoestrogens on Liver and Brain Fractions". Paper presented in 17th National Congress of Biochemistry, Porto, Portugal, December 15-17, 2010, 2010.
  69. Alves, Estela; Moreira, Ana C.; Silva, Ana M.; Santos, Maria S.; Sardão, Vilma. "Mitochondrial Safety of Phytoestrogens: Searching for an Alternative Hormone Replacement Therapy". Paper presented in 2nd National Meeting on Medicinal Chemistry, Coimbra, Portugal, 2010.
  70. Moreira, Ana C.; Silva, Ana M.; Alves, Estela; Santos, Maria S.; Sardão, Vilma. "Antioxidant Effects of Selected Phytoestrogens in Brain and Liver Mitochondria". Paper presented in SFRBM's 17th Annual Meeting, Orlando Florida, USA, 2010.
  71. Sardão, Vilma; Rose-Hellekant, Teresa; Perkins, Edward; Greene, Amy; Holy, Jon. "Cell motility is enhanced by autocrine factors in a murine model of breast cancer". Paper presented in AICR 30th Anniversary Conference: Today’s research – Tomorrow’s therapies, St Andrews, Fife, Scotland, 2010.
  72. Moreira, Ana C.; Branco, Ana F.; Oliveira, Paulo; Sardão, Vilma. "Caspase-independent apoptosis induced by Doxorubicin on Embryonic Ventricular H9c2 Myoblasts – Role of Apoptosis Inducing Factor (AIF) and Endonuclease G". Paper presented in 44th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, Italy, 2010.
  73. Gonçalves, Inês; Carneiro, D.; Lumini-Oliveira, José; Machado, Nuno; Marques, F.; Sardão, Vilma; Oliveira, Paulo; Magalhães, José; Ascensão, António. "Effects of acute endurance exercise on heart and liver mitochondrial function in rats treated with Doxorubicin". Paper presented in 3rd Meeting of Young Researchers of University of Porto, Porto, Portugal, 2010.
  74. Branco, Ana F.; Moreira, Ana C.; Pereira, Susana P; Sardão, Vilma; Oliveira, Paulo. "Toxicity of Isoproterenol Increases with the Differentiation State of H9c2 Myoblasts". Paper presented in 49th ASCB Annual Meeting, San Diego, CA, USA, 2009.
  75. Sardão, Vilma; Rose-Hellekant, Teresa; Perkins, Edward; Greene, Amy; Holy, Jon. "Regulation of cell motility in a novel murine breast cancer model system: Autocrine and mesenchymal stem cell effects". Paper presented in Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications, San Diego, California, USA, 2009.
  76. Ascensão, António; Lumini-Oliveira, José; Machado, Nuno; Gonçalves, Inês; Carneiro, Diogo; Marques, Franklim; Sardão, Vilma; Magalhães, José; Oliveira, Paulo. "Effects of Acute Endurance Exercise on Heart and Liver Mitochondrial Function in Rats Treated With Doxorubicin". Paper presented in 7th Annual Scientific Session, Society for Heart and Vascular Metabolism, Padova, Italy, 2009.
  77. Sardão, Vilma; Rose-Hellekant, Teresa; Perkins, Edward; Greene, Amy; Holy, Jon. "Cross-talk between mesenchymal stem cells and breast cancer cells – effects on cell motility". Paper presented in 18th Annual Short Course on Experimental Models of Human Cancer, The Jackson Laboratory, Highseas, Maine, USA, 2009.
  78. Braga, T. M.; Marques, J.; Paz, F. A. A.; Pillinger, M.; Branco. Ana F.; Sardão, Vilma; Diogo, Cátia V.; et al. "Nano-encapsulation of Antitumoral Metal Drug Candidates using Cyclodextrins". Paper presented in Nanomedicine 2009, 2nd European Summer School in Nanomedicine, Lisboa, Portugal, 2009.
  79. Branco, Ana F.; Moreira, Ana C.; Holy, Jon; Wallace, Kendall B.; Oliveira, Paulo; Sardão, Vilma. "Differential Sensitivity of Undifferentiated and Differentiated H9c2 Myoblasts to the Cardiotoxicant Doxorubicin". Paper presented in Molecular Regulation of Cardiac Disease Symposium, London, UK,, 2009.
  80. Serafim, Teresa; Sardão, Vilma; Matos, Júlio A.; Pereira, Gonçalo C.; Branco, Ana F.; Pereira, Sandro L.; Parke, Donna; et al. "Sanguinarine Inhibits the Proliferation of Metastatic Melanoma Cells by Nuclear and Mitochondrial Effects". Paper presented in Chemistry in Cancer Research: A Vital Partnership in Cancer Drug Discovery and Development, New Orleans, Louisiana, USA, 2009.
  81. Silva, Filomena S.G.; Sardão, Vilma; Oliveira, Paulo; Santos, Maria S.; Sousa, Maria do Céu; Santos-Silva, Alice; Pereira, Petronila Rocha. "Effects of 13-cis-RA and acitretin on tumor cell proliferation and isolated liver mitochondria". Paper presented in 16th National Congress of Biochemistry, Ponta Delgada, São Miguel, Açores, Portugal, 2008.
  82. Serafim, Teresa; Branco, Ana F.; Matos, Júlio A. C.; Sardão, Vilma; Pereira, Gonçalo C.; Parke, Donna; Perkins, Edward; et al. "Sanguinarine Cytotoxicity on Mouse Melanoma K1735-M2 Cells – Nuclear versus Mitochondrial Effects". Paper presented in 16th National Congress of Biochemistry, Ponta Delgada, São Miguel, Açores, Portugal, 2008.
  83. Silva, João P.; Sardão, Vilma; Proença, Fernanda; Coutinho, Olga P.; Oliveira, Paulo. "Nitrogen compounds as protectors of oxidative damage induced in H9c2 myoblasts". Paper presented in 16th Euroconference on Apoptosis & 5th Swiss Apoptosis Meeting, Bern, Switzerland,, 2008.
  84. Sardão, Vilma; Oliveira, Paulo; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.. "Doxorubicin Toxicity in H9c2 Embryonic Cardiomyoblasts: Morphological Alterations and Activation of p53-Bax Signaling Pathway". Paper presented in 6th Annual meeting of the Society for Heart and Vascular Metabolism, Boston, Massachusetts, USA, 2008.
  85. Branco, Ana F.; Sardão, Vilma; Pereira, Sandro L.; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.; Oliveira, Paulo. "Differentiation of H9c2 embrionic ventricular cells results into increased susceptibility to the cardiac toxicants dosorubicin and isoproterenol". Paper presented in 6th Annual meeting of the Society for Heart and Vascular Metabolism, Boston, Massachusetts, USA, 2008.
  86. Pereira, Sandro L.; Sardão, Vilma; Branco, Ana F.; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.; Oliveira, Paulo. "Toxicity of Doxorubicin and Isoproterenol Depends on the Differentiation Stage of H9c2 Myoblasts". Paper presented in Society of Toxicology Annual Meeting 2008, Seattle, WA, EUA, 2008.
  87. Sardão, Vilma; Oliveira, Paulo; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.. "Doxorubicin induces Apoptosis in H9c2 myoblasts – Contribution of P53/Bax pathways and oxidative stress". Paper presented in Apoptosis World 2008, From Mechanisms to Applications, Luxembourg, 2008.
  88. Branco, Ana F.; Pereira, Sandro L.; Sardão, Vilma; Wallace, Kendall B.; Oliveira, Paulo. "Apoptotic effect of isoproterenolon H9c2 myoblasts: Relevance of differentiation State". Paper presented in Apoptosis World 2008, From Mechanisms to Applications, Luxembourg,, 2008.
  89. Serafim, Teresa; Sardão, Vilma; Carvalho, Filipa S.; Marques, Maria P.; Garrido, Jorge; Milhazes, Nuno; Borges, Fernanda; et al. "Antiproliferative activity of ferulic and caffeic acid derivatives on tumor cell lines – Structure-function relations and direct effects on mitochondria". Paper presented in Apoptosis World 2008, From Mechanisms to Applications, Luxembourg, 2008.
  90. Sardão, Vilma; Oliveira, Paulo; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.. "Morphological Hallmarks of Doxorubicin Toxicity on H9c2 Myoblasts: The pro-oxidant action of the antineoplastic agent". Paper presented in European Meeting of the Society for Free Radical Research, Vilamoura, Portugal, 2007.
  91. Braga, Susana S.; Mokal, Vijaya; Paz, Filipe A. A.; Marques, Maria P. M.; Branco, Ana F.; Sardão, Vilma; Oliveira, Paulo; et al. "Cyclodextrin encapsulation of biomimetic organometallic cancer drud candidates". Paper presented in 6th International Medicinal Chemistry Symposium, Istanbul, Turkey, 2007.
  92. Sardão, Vilma; Oliveira, Paulo; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.. "Morphologic Alterations Induced by the Antineoplastic Agent Doxorubicin in H9c2 myoblasts: Relevance for Doxorubicin Cardiotoxicity". Paper presented in First Iberic Meeting on Medicinal Chemistry – Anticancer Agents, Regua, Portugal, 2007.
  93. Serafim, Teresa; Sardão, Vilma; Holy, Jon; Marques, Maria P.; Batista de Carvalho, Luís A.E.; Garrido, Jorge; Milhazes, Nuno; et al. "Anti-proliferative profile of potential lipophilic antioxidants structurally based on the dietary antioxidants ferulic and caffeic acids". Paper presented in First Iberic Meeting on Medicinal Chemistry – Anticancer Agents, Regua, Portugal, 2007.
  94. Sardão, Vilma; Oliveira, Paulo; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.. "The H9c2 cell Line as a Model for Cardiotoxicology Studies – Imaging of Cell Dysfunction Induced By Tert-Butylhydroperoxide". Paper presented in XV National Congress of Biochemistry, Aveiro, Portugal, 2006.
  95. Pereira, Gonçalo C.; Serafim, Teresa; Sardão, Vilma; Teles, Ana I.; Moreno, António J. M.; Parke, Donna; Perkins, Edward; Holy, Jon; Oliveira, Paulo. "Berberine-induced Mitochondrial Depolarization and Fragmentation in K1735-M2 Rat Melanoma Cells – A Possible Mechanism for Berberine Anti-proliferative / Pro-apoptotic actions". Paper presented in XV National Congress of Biochemistry, Aveiro, Portugal, 2006.
  96. Matos, Júlio A.; Serafim, Teresa; Sardão, Vilma; Branco, Ana F.; Moreno, António J. M.; Parke, Donna; Perkins, Edward; Holy, Jon; Oliveira, Paulo. "Mitochondrial Involvement in Sanguinarine-Induced Apoptosis". Paper presented in XV National Congress of Biochemistry, Aveiro, Portugal, 2006.
  97. Marques, Maria P.; Amado, A.M.; Fiuza, S.M.; Oliveira, Paulo; Sardão, Vilma; Soares, Ana S; Urbano, Ana M.; Batista De Carvalho, L.A.E.. "Polynuclear Pt(II) and Pd(II) Polyamine Complexes as Novel Anticancer Agents,". Paper presented in XXXVII Meeting of Portuguese Society of Pharmacology, 2006, Porto, Portugal, 2006.
  98. Moreira, Ana C.; Branco, Ana F.; Holy, Jon; Oliveira, Paulo; Santos, Maria S.; Sardão, Vilma. "Role of the Apoptosis Inducing Factor and Endonuclease G in the Cytotoxicity of Doxorubicin on Embryonic Ventricular H9c2 cells". Paper presented in 7th Annual meeting of the Society for Heart and Vascular Metabolism, Padova, Italy, 2006.
  99. Fiuza, Sónia; Amado, Ana M; Oliveira, Paulo; Sardão, Vilma; Marques, Maria P.; Batista de Carvalho, Luís A.E.. "Pt(II) and Pd(II) Complexes with Biogenic Amines - Structure-Activity Study". Paper presented in First European Conference on Chemistry for Life Sciences. Rimini, Italy, 2005.
  100. Fiuza, Sónia; Amado, Ana M.; Oliveira, Paulo; Sardão, Vilma; Marques, Maria P.; Batista de Carvalho, Luis A.E.. "Structure-Activity Study of Pt(II) and Pd(II) Spermidine Complexes". Paper presented in 12th International Conference on Biological Inorganic Chemistry - ICBIC12, Ann Arbor, Michigan, USA, 2005.
  101. Sardão, Vilma; Oliveira, Paulo; Monteiro, Pedro; Gonçalves, Lino; Providência, Luís A.; Moreno, Antonio J. M.. "Caffeine Induces Cytochrome c Release and Reduces Cardiac Mitochondrial ATP Production". Paper presented in XXIV Congresso Portugues de Cardiologia , Madeira (Portugal), 2003.
  102. Sardão, Vilma; Oliveira, Paulo; Monteiro, Pedro; Gonçalves, Lino; Moreno, António J. M.. "Toxicity of Caffeine in Heart Mitochondria: Enhancement of Permeability Transition and Disturbance of Mitochondrial Bioenergetic Processes". Paper presented in XIII Congresso Português de Bioquímica, Lisboa (Portugal), 2002.
  103. Sardão, Vilma; Oliveira, Paulo; Monteiro, Pedro; Gonçalves, Lino; Moreno, António J. M.. "Toxicity of Caffeine in Heart Mitochondria: Enhancement of Permeability Transition and Disturbance of Mitochondrial Bioenergetic Processes". Paper presented in European Bioenergetics Conference (EBEC), Arcachon, Bordeaux, France, 2002.
  104. Sardão, Vilma; Oliveira, Paulo; Monteiro, Pedro; Gonçalves, Lino; Providência, Luís A.; Moreno, António J. M.. "Mitocôndrias Cardíacas e Cafeína – Desregulação da Homeostase do Cálcio e Interacções com Cadeia Respiratória". Paper presented in XXIII Congresso Português de Cardiologia, Vilamoura, Portugal, 2002.
  105. Oliveira, Paulo; Rolo, Anabela P.; Coxito, Pedro; Santos, Dario L.; Sardão, Vilma; Seiça, Raquel; Monteiro, Pedro; et al. "Mitochondria From Diabetic Rats Cardiomyocytes are more resistent to the Induction of Permeability Transition Pore". Paper presented in 2nd European Meeting on Vascular Biology and Medicine, ULM, German, 2001.
  106. Sardão, Vilma; Oliveira, Paulo; Monteiro, Pedro; Gonçalves, Lino; Providência, Luís A.; Moreno, António J. M.. "Caffeine Induces Directly the Permeability Transition in Isolated Rat Heart Mitochondria". Paper presented in XXII Congresso Português de Cardiologia, Vilamoura, Portugal, 2001.
  107. Oliveira, Paulo; Rolo, Anabela P.; Seiça, Raquel; Sardão, Vilma; Monteiro, Pedro; Gonçalves, Lino; Providência, Luís A.; et al. "Heart Mitochondria From Diabetic Rats Are More Resistant to the Induction of the Mitochondrial Permeability Transition". Paper presented in XXII Congresso Português de Cardiologia, Vilamoura, Portugal, 2001.
  108. Oliveira, Paulo; Rolo, Anabela P.; Coxito, Pedro M.; Santos, Dario L.; Sardão, Vilma; Seiça, Raquel; Palmeira, Carlos M.; Santos, Maria S.; Moreno, António J. M.. "Decreased Susceptibility of Heart Mitochondria From Diabetic GK Rats to Mitochondrial Permeability Transition Induced by Calcium/Phosphate". Paper presented in II Congresso de Investigação em Medicina, Coimbra, Portugal, 2000.
  109. Paulo J. Oliveira; Pedro M. Coxito; Anabela P. Rolo; Sardão, Vilma; Carlos M. Palmeira; António J. M. Moreno. "Carvedilol in Heart Mitochondria: Protonophore or Opener of the Mitochondrial KATP Channels?". Paper presented in XII Congresso Português de Bioquímica, 2000.
  110. Oliveira, Paulo; Coxito, Pedro M.; Rolo, Anabela P.; Sardão, Vilma; Palmeira, Carlos M.; Moreno, Antonio J. M.. "Carvedilol in Heart Mitochondria: Protonophore or Opener of the Mitochondrial KATP Channels?". Paper presented in XII Congresso Português de Bioquímica, Póvoa do Varzim, Portugal., 2000.
Journal article
  1. Monika Prill; Vilma A. Sardão; Mateusz Sobczak; Dominika Nowis; Jedrzej Szymanski; Mariusz R. Wieckowski. "p66Shc Protein—Oxidative Stress Sensor or Redox Enzyme: Its Potential Role in Mitochondrial Metabolism of Human Breast Cancer". Cancers (2024): https://doi.org/10.3390/cancers16193324.
    10.3390/cancers16193324
  2. Adriana Marques-Carvalho; Beatriz Silva; Francisco B. Pereira; Ha-Neui Kim; Maria Almeida; Vilma A. Sardão. "Oestradiol and osteoclast differentiation: Effects on p53 and mitochondrial metabolism". European Journal of Clinical Investigation (2024): https://doi.org/10.1111/eci.14195.
    10.1111/eci.14195
  3. Miguel Pinto; Tiago Barros Silva; Sardão, Vilma; Rui Simões; Bárbara Albuquerque; Paulo J. Oliveira; Maria João Valente; et al. "Cellular and Mitochondrial Toxicity of Tolcapone, Entacapone, and New Nitrocatechol Derivatives". ACS Pharmacology & Translational Science 7 (2024): 1637-1649.
    10.1021/acsptsci.4c00124
  4. Ferreiro, Elisabete; Monteiro, Mariana; Pereira, Francisco; Barroso, Cristina; Egas, Conceição; Macedo, Paula; Valero, Jorge; Sardão, Vilma A.; Oliveira, Paulo J.. "Age-dependent energy metabolism and transcriptome changes in urine-derived stem cells". Mechanisms of Ageing and Development 218 (2024): 111912. http://dx.doi.org/10.1016/j.mad.2024.111912.
    10.1016/j.mad.2024.111912
  5. Yaiza Potes; Juan C. Bermejo-Millo; Catarina Mendes; José P. Castelão-Baptista; Andrea Díaz-Luis; Zulema Pérez-Martínez; Juan J. Solano; et al. "p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence". Cell Death & Disease (2024): https://doi.org/10.1038/s41419-024-06582-0.
    10.1038/s41419-024-06582-0
  6. Amorim, Ricardo; Magalhães, Carina C.; Benfeito, Sofia; Cagide, Fernando; Tavares, Ludgero C.; Santos, Katia; Sardão, Vilma A.; et al. "Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN6 sensitizes cisplatin lung anticancer therapy due to a remodeling of energy metabolism". Biochemical Pharmacology 219 (2024): 115953. http://dx.doi.org/10.1016/j.bcp.2023.115953.
    10.1016/j.bcp.2023.115953
  7. Cláudia Bessa; Joana B. Loureiro; Matilde Barros; Vera M. S. Isca; Vilma A. Sardão; Paulo J. Oliveira; Raquel L. Bernardino; et al. "Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCd Activator". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24065710.
    10.3390/ijms24065710
  8. Adriana Marques-Carvalho; Sardão, Vilma; Ha-Neui Kim; Maria Almeida. Corresponding author: Maria Almeida. "ECSIT is essential for RANKL-induced stimulation of mitochondria in osteoclasts and a target for the anti-osteoclastogenic effects of estrogens". Frontiers in Endocrinology (2023):
    Published
  9. José P. Castelão-Baptista; Sara A. Valente; Sara Canário; David Oppolzer; Ana Barros; Carlos Venâncio; Tânia Martins; et al. "Brassica oleracea Var italica by-Products Prevent Lipid Accumulation and Cell Death in a Liver Cell Model of Lipid Toxicity". Nutrients (2023): https://doi.org/10.3390/nu15040924.
    10.3390/nu15040924
  10. Ana Pedrosa; Guilherme Furtado; Marcelo Paes de Barros; André Luís Lacerda Bachi; José Pedro Ferreira; Vilma A. Sardão; Luís Rama; Ana Teixeira. "The Impact of Moderate-to-High-Intensity Exercise Protocols on Glycated Hemoglobin Levels in Type 2 Diabetes Patients". Diabetology (2022): https://doi.org/10.3390/diabetology4010002.
    10.3390/diabetology4010002
  11. Alves-Silva, Jorge M.; Zuzarte, Mónica; Marques, Carla; Viana, Sofia; Preguiça, Inês; Baptista, Rui; Ferreira, Cátia; et al. "1,8-cineole Ameliorates Right Ventricle Dysfunction Associated With Pulmonary Arterial Hypertension by Restoring Connexin 43 and Mitochondrial Homeostasis". Pharmacological Research (2022): 106151. http://dx.doi.org/10.1016/j.phrs.2022.106151.
    10.1016/j.phrs.2022.106151
  12. Cunha-Oliveira, T.; Carvalho, M.; Sardão, V.; Ferreiro, E.; Mena, D.; Pereira, F.B.; Borges, F.; et al. "Integrative Profiling of Amyotrophic Lateral Sclerosis Lymphoblasts Identifies Unique Metabolic and Mitochondrial Disease Fingerprints". Molecular Neurobiology 59 10 (2022): 6373-6396. http://www.scopus.com/inward/record.url?eid=2-s2.0-85135617163&partnerID=MN8TOARS.
    Submitted • 10.1007/s12035-022-02980-7
  13. Giampaolo Morciano; Natalia Naumova; Piotr Koprowski; Sara Valente; Vilma A. Sardão; Yaiza Potes; Alessandro Rimessi; Mariusz R. Wieckowski; Paulo J. Oliveira. "The mitochondrial permeability transition pore: an evolving concept critical for cell life and death". Biological Reviews (2021): https://doi.org/10.1111/brv.12764.
    10.1111/brv.12764
  14. Emilio Molina-Molina; Guilherme E. Furtado; John G. Jones; Piero Portincasa; Ana Vieira-Pedrosa; Ana Maria Teixeira; Marcelo P. Barros; André L. Bachi; Vilma A. Sardão. "The advantages of physical exercise as a preventive strategy against NAFLD in Postmenopausal Women". European Journal of Clinical Investigation (2021): https://doi.org/10.1111/eci.13731.
    10.1111/eci.13731
  15. Dias-Pedroso, Daniela; Ramalho, José S.; Sardão, Vilma A.; Jones, John G.; Romão, Carlos C.; Oliveira, Paulo J.; Vieira, Helena L.A.. "Carbon Monoxide-Neuroglobin Axis Targeting Metabolism Against Inflammation in BV-2 Microglial Cells". Molecular Neurobiology (2021): http://dx.doi.org/10.1007/s12035-021-02630-4.
    10.1007/s12035-021-02630-4
  16. José P. Castelão-Baptista; A.I.R.N.A.Barros; Tânia Martins; Eduardo Rosa; Vilma A. Sardão. "Three in One: The Potential of Brassica By-Products against Economic Waste, Environmental Hazard, and Metabolic Disruption in Obesity". Nutrients (2021): https://www.mdpi.com/2072-6643/13/12/4194.
    10.3390/nu13124194
  17. Bruno M. Moukette; José P. Castelão-Baptista; Luciana Ferreira; Ana M. Silva; Rui F. Simões; Célia Cabral; Constant A. Pieme; et al. "Afrostyrax lepidophyllus Mildbr. and Monodora myristica (Gaertn.) Dunal Extracts Decrease Doxorubicin Cytotoxicity on H9c2 Cardiomyoblasts". Evidence-Based Complementary and Alternative Medicine (2021): https://doi.org/10.1155/2021/8858165.
    10.1155/2021/8858165
  18. Cardoso, Henrique J.; Figueira, Marília I.; Vaz, Cátia V.; Carvalho, Tiago M. A.; Brás, Luís A.; Madureira, Patrícia A.; Oliveira, Paulo J.; Sardão, Vilma; Socorro, Sílvia. "Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5a-dihydrotestosterone regulation". Cellular Oncology (2021): http://dx.doi.org/10.1007/s13402-020-00575-9.
    10.1007/s13402-020-00575-9
  19. Guilherme Eustáquio Furtado; Rubens Vinícius Letieri; Adriana Caldo; Vilma Sardão; Ana Maria Teixeira; Marcelo Paes de Barros; Rodolfo Paula Vieira; André Luís Lacerda Bachi. "Sustaining efficient immune functions with regular physical exercise in the COVID-19 era and beyond". European Journal of Clinical Investigation (2021): https://doi.org/10.1111/eci.13485.
    10.1111/eci.13485
  20. Sousa, Bárbara; Pereira, Joana; Marques, Ricardo; Grilo, Luís F.; Pereira, Susana P.; Sardão, Vilma A.; Schmitt, Fernando; Oliveira, Paulo J.; Paredes, Joana. "P-cadherin induces anoikis-resistance of matrix-detached breast cancer cells by promoting pentose phosphate pathway and decreasing oxidative stress". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 12 (2020): 165964. http://dx.doi.org/10.1016/j.bbadis.2020.165964.
    10.1016/j.bbadis.2020.165964
  21. Serafim, Teresa L.; Cunha-Oliveira, Teresa; Deus, Claudia M.; Sardão, Vilma A.; Cardoso, Ines M.; Yang, Shanshan; Odhiambo, John F.; et al. "Maternal obesity in sheep impairs foetal hepatic mitochondrial respiratory chain capacity". European Journal of Clinical Investigation (2020): http://dx.doi.org/10.1111/eci.13375.
    10.1111/eci.13375
  22. Kim, Ha-Neui; Ponte, Filipa; Nookaew, Intawat; Ucer Ozgurel, Serra; Marques-Carvalho, Adriana; Iyer, Srividhya; Warren, Aaron; et al. "Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-68890-7.
    Published • 10.1038/s41598-020-68890-7
  23. Wallace, Kendall B.; Sardão, Vilma A.; Oliveira, Paulo J.. "Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy". Circulation Research 126 7 (2020): 926-941. http://dx.doi.org/10.1161/circresaha.119.314681.
    10.1161/circresaha.119.314681
  24. Bento, Guida; Shafigullina, Aygul K.; Rizvanov, Albert A.; Sardão, Vilma A.; Macedo, Maria Paula; Oliveira, Paulo J.. "Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine". Cells 9 3 (2020): 573. http://dx.doi.org/10.3390/cells9030573.
    10.3390/cells9030573
  25. Rodrigues, Elsa T.; Varela, Ana T.; Pardal, Miguel A.; Sardão, Vilma A.. "Cell-based assays as an alternative for the study of aquatic toxicity of pharmaceuticals". Environmental Science and Pollution Research (2019): http://dx.doi.org/10.1007/s11356-019-07384-0.
    10.1007/s11356-019-07384-0
  26. Veloso, Caroline D.; Belew, Getachew D.; Ferreira, Luciana L.; Grilo, Luís F.; Jones, John G.; Portincasa, Piero; Sardão, Vilma A.; Oliveira, Paulo J.. "A Mitochondrial Approach to Cardiovascular Risk and Disease". Current Pharmaceutical Design 25 29 (2019): 3175-3194. http://dx.doi.org/10.2174/1389203720666190830163735.
    10.2174/1389203720666190830163735
  27. Grasselli, Elena; Baldini, Francesca; Vecchione, Giulia; Oliveira, Paulo; Sard¿o, Vilma; Voci, Adriana; Portincasa, Piero; Vergani, Laura. "Excess fructose and fatty acids trigger a model of non-alcoholic fatty liver disease progression in vitro: Protective effect of the flavonoid silybin". International Journal of Molecular Medicine (2019): http://dx.doi.org/10.3892/ijmm.2019.4234.
    10.3892/ijmm.2019.4234
  28. Bajzikova, Martina; Kovarova, Jaromira; Coelho, Ana R.; Boukalova, Stepana; Oh, Sehyun; Rohlenova, Katerina; Svec, David; et al. "Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells". Cell Metabolism 29 2 (2019): 399-416.e10. http://dx.doi.org/10.1016/j.cmet.2018.10.014.
    10.1016/j.cmet.2018.10.014
  29. Giorgi, Carlotta; Marchi, Saverio; Simoes, Ines C.M.; Ren, Ziyu; Morciano, Giampaolo; Perrone, Mariasole; Patalas-Krawczyk, Paulina; et al. "Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases". International Review of Cell and Molecular Biology 340 (2018): 209-344. http://dx.doi.org/10.1016/bs.ircmb.2018.05.006.
    Published • 10.1016/bs.ircmb.2018.05.006
  30. Teixeira, Jose; Amorim, Ricardo; Santos, Katia; Soares, Pedro; Datta, Sandipan; Cortopassi, Gino A; Serafim, Teresa L; et al. "Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative.". Toxicology 393 (2018): 123-139. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:29141199&KeyUID=MEDLINE:29141199.
    10.1016/j.tox.2017.11.014
  31. Vecchione, Giulia; Grasselli, Elena; Cioffi, Federica; Baldini, Francesca; Oliveira, Paulo J.; Sardao, Vilma A.; Cortese, Katia; et al. "The Nutraceutic Silybin Counteracts Excess Lipid Accumulation and Ongoing Oxidative Stress in an In Vitro Model of Non-Alcoholic Fatty Liver Disease Progression". Frontiers in Nutrition 4 (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000411196400001&KeyUID=WOS:000411196400001.
    10.3389/fnut.2017.00042
  32. Wojtala, Aleksandra; Karkucinska-Wieckowska, Agnieszka; Sardao, Vilma A.; Szczepanowska, Joanna; Kowalski, Pawel; Pronicki, Maciej; Duszynski, Jerzy; Wieckowski, Mariusz R.. "Modulation of mitochondrial dysfunction-related oxidative stress in fibroblasts of patients with Leigh syndrome by inhibition of prooxidative p66Shc pathway". Mitochondrion 37 (2017): 62-79. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000416296000008&KeyUID=WOS:000416296000008.
    10.1016/j.mito.2017.07.002
  33. Moreira, Ana C.; Silva, Ana M.; Branco, Ana F.; Baldeiras, Ines; Peteira, Goncalo C.; Seica, Raquel; Santos, Maria S.; Sardao, Vilma A.. "Phytoestrogen coumestrol improves mitochondrial activity and decreases oxidative stress in the brain of ovariectomized Wistar-Han rats". Journal of Functional Foods 34 (2017): 329-339. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000403383800036&KeyUID=WOS:000403383800036.
    10.1016/j.jff.2017.05.002
  34. Branco, Ana F.; Ferreira, André; Simões, Rui F.; Magalhães-Novais, Sílvia; Zehowski, Cheryl; Cope, Elisabeth; Silva, Ana Marta; et al. "Ketogenic diets: from cancer to mitochondrial diseases and beyond". European Journal of Clinical Investigation 46 3 (2016): 285-298. http://dx.doi.org/10.1111/eci.12591.
    Published • 10.1111/eci.12591
  35. Deus, C.M.; Serafim, T.L.; Magalhães-Novais, S.; Vilaça, A.; Moreira, A.C.; Sardão, V.A.; Cardoso, S.M.; Oliveira, P.J.. "Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells". Archives of Toxicology (2016): 1-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976428138&partnerID=MN8TOARS.
    10.1007/s00204-016-1784-x
  36. Jiménez-Chillarón, J.C.; Nijland, M.J.; Ascensão, A.A.; Sardão, V.A.; Magalhães, J.; Hitchler, M.J.; Domann, F.E.; Oliveira, P.J.. "Back to the future: Transgenerational transmission of xenobiotic-induced epigenetic remodeling". Epigenetics 10 4 (2015): 259-273. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927770406&partnerID=MN8TOARS.
    10.1080/15592294.2015.1020267
  37. Ferreira, A.; Serafim, T.L.; Sardão, V.A.; Cunha-Oliveira, T.. "Role of mtDNA-related mitoepigenetic phenomena in cancer". European Journal of Clinical Investigation 45 s1 (2015): 44-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919393955&partnerID=MN8TOARS.
    10.1111/eci.12359
  38. Moreira, A.C.; Branco, A.F.; Sampaio, S.F.; Cunha-Oliveira, T.; Martins, T.R.; Holy, J.; Oliveira, P.J.; Sardão, V.A.. "Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts". Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 12 (2014): 2468-2478. http://www.scopus.com/inward/record.url?eid=2-s2.0-84910051188&partnerID=MN8TOARS.
    10.1016/j.bbadis.2014.09.015
  39. Branco, A.F.; Moreira, A.C.; Cunha-Oliveira, T.; Couto, R.; Sardão, V.A.; Rizvanov, A.A.; Palotás, A.; Oliveira, P.J.. "ß-adrenergic over-stimulation and cardio-myocyte apoptosis: Two receptors, one organelle, two fates?". Current Drug Targets 15 10 (2014): 956-964. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925936688&partnerID=MN8TOARS.
  40. Moreira, A.C.; Silva, A.M.; Santos, M.S.; Sardão, V.A.. "Phytoestrogens as alternative hormone replacement therapy in menopause: What is real, what is unknown". Journal of Steroid Biochemistry and Molecular Biology 143 (2014): 61-71. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896338551&partnerID=MN8TOARS.
    10.1016/j.jsbmb.2014.01.016
  41. Oliveira, M.M.; Teixeira, J.C.; Vasconcelos-Nóbrega, C.; Felix, L.M.; Sardão, V.A.; Colaço, A.A.; Oliveira, P.A.; Peixoto, F.P.. "Mitochondrial and liver oxidative stress alterations induced by N-butyl-N-(4-hydroxybutyl)nitrosamine: Relevance for hepatotoxicity". Journal of Applied Toxicology 33 6 (2013): 434-443. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876712347&partnerID=MN8TOARS.
    10.1002/jat.1763
  42. Branco, A.F.; Sampaio, S.F.; Wieckowski, M.R.; Sardão, V.A.; Oliveira, P.J.. "Mitochondrial disruption occurs downstream from ß-adrenergic overactivation by isoproterenol in differentiated, but not undifferentiated H9c2 cardiomyoblasts: Differential activation of stress and survival pathways". International Journal of Biochemistry and Cell Biology 45 11 (2013): 2379-2391. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883513016&partnerID=MN8TOARS.
    10.1016/j.biocel.2013.08.006
  43. Moreira, A.C.; Silva, A.M.; Santos, M.S.; Sardão, V.A.. "Resveratrol affects differently rat liver and brain mitochondrial bioenergetics and oxidative stress in vitro: Investigation of the role of gender". Food and Chemical Toxicology 53 (2013): 18-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871464946&partnerID=MN8TOARS.
    10.1016/j.fct.2012.11.031
  44. Branco, A.F.; Sampaio, S.F.; Moreira, A.C.; Holy, J.; Wallace, K.B.; Baldeiras, I.; Oliveira, P.J.; Sardão, V.A.. "Differentiation-dependent doxorubicin toxicity on h9c2 cardiomyoblasts". Cardiovascular Toxicology 12 4 (2012): 326-340. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870546889&partnerID=MN8TOARS.
    10.1007/s12012-012-9177-8
  45. Branco, Ana F.; Pereira, Sandro L.; Moreira, Ana C.; Holy, Jon; Sardão, Vilma A.; Oliveira, Paulo J.. "Isoproterenol Cytotoxicity is Dependent on the Differentiation State of the Cardiomyoblast H9c2 Cell Line". Cardiovascular Toxicology 11 3 (2011): 191-203. http://dx.doi.org/10.1007/s12012-011-9111-5.
    10.1007/s12012-011-9111-5
  46. Alves, M.G.; MacHado, N.G.; Sardão, V.A.; Carvalho, R.A.; Oliveira, P.J.. "Anti-apoptotic protection afforded by cardioplegic celsior and histidine buffer solutions to hearts subjected to ischemia and ischemia/reperfusion". Journal of Cellular Biochemistry 112 12 (2011): 3872-3881. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055000219&partnerID=MN8TOARS.
    10.1002/jcb.23320
  47. Sardão, V.; Rose-Hellekant, T.; Perkins, E.; Greene, A.; Holy, J.. "Measuring reciprocal regulation of mesenchymal stem cell and tumor cell motility in two and three dimensions in vitro". Stem Cell Research Journal 3 4 (2011): 281-305. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879738670&partnerID=MN8TOARS.
  48. Ascensão, A.; Lumini-Oliveira, J.; Machado, N.G.; Ferreira, R.M.; Gonçalves, I.O.; Moreira, A.C.; Marques, F.; et al. "Acute exercise protects against calcium-induced cardiac mitochondrial permeability transition pore opening in doxorubicin-treated rats". Clinical Science 120 1 (2011): 37-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650871083&partnerID=MN8TOARS.
    10.1042/CS20100254
  49. Pereira, S.L.; Ramalho-Santos, J.; Branco, A.F.; Sardão, V.A.; Oliveira, P.J.; Carvalho, R.A.. "Metabolic remodeling during H9c2 myoblast differentiation: Relevance for in vitro toxicity studies". Cardiovascular Toxicology 11 2 (2011): 180-190. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958056642&partnerID=MN8TOARS.
    10.1007/s12012-011-9112-4
  50. Branco, A.F.; Pereira, S.L.; Moreira, A.C.; Holy, J.; Sardão, V.A.; Oliveira, P.J.. "Erratum: Isoproterenol cytotoxicity is dependent on the differentiation state of the cardiomyoblast H9c2 cell line (Cardiovascular Toxicology DOI: 10.1007/s12012-011-9111-5)". Cardiovascular Toxicology 11 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80054890288&partnerID=MN8TOARS.
    10.1007/s12012-011-9131-1
  51. Silva, J.P.; Sardão, V.A.; Coutinho, O.P.; Olveira, P.J.. "Nitrogen compounds prevent H9c2 myoblast oxidative stress-induced mitochondrial dysfunction and cell death". Cardiovascular Toxicology 10 1 (2010): 51-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951143286&partnerID=MN8TOARS.
    10.1007/s12012-010-9062-2
  52. Silva, J.P.; Sardão, V.A.; Coutinho, O.P.; Oliveira, P.J.. "Erratum: Nitrogen compounds prevent H9c2 myoblast oxidative stress-induced mitochondrial dysfunction and cell death (Cardiovascular Toxicology (2010) 10 (51-65) DOI:10.1007/s12012-010-9062-2)". Cardiovascular Toxicology 10 2 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956395509&partnerID=MN8TOARS.
    10.1007/s12012-010-9067-x
  53. Sardão, V.A.; Oliveira, P.J.; Holy, J.; Oliveira, C.R.; Wallace, K.B.. "Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts". Cancer Chemotherapy and Pharmacology 64 4 (2009): 811-827. http://www.scopus.com/inward/record.url?eid=2-s2.0-68149169047&partnerID=MN8TOARS.
    10.1007/s00280-009-0932-x
  54. Pereira, C.V.; Moreira, A.C.; Pereira, S.P.; Machado, N.G.; Carvalho, F.S.; Sardão, V.A.; Oliveira, P.J.. "Investigating drug-induced mitochondrial toxicity: A biosensor to increase drug safety?". Current Drug Safety 4 1 (2009): 34-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-63249131066&partnerID=MN8TOARS.
    10.2174/157488609787354440
  55. Sardão, V.A.; Oliveira, P.J.; Holy, J.; Oliveira, C.R.; Wallace, K.B.. "Morphological alterations induced by doxorubicin on H9c2 myoblasts: Nuclear, mitochondrial, and cytoskeletal targets". Cell Biology and Toxicology 25 3 (2009): 227-243. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349167673&partnerID=MN8TOARS.
    10.1007/s10565-008-9070-1
  56. Serafim, T.L.; Oliveira, P.J.; Sardao, V.A.; Perkins, E.; Parke, D.; Holy, J.. "Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line". Cancer Chemotherapy and Pharmacology 61 6 (2008): 1007-1018. http://www.scopus.com/inward/record.url?eid=2-s2.0-41049098849&partnerID=MN8TOARS.
    10.1007/s00280-007-0558-9
  57. Serafim, T.L.; Matos, J.A.C.; Sardão, V.A.; Pereira, G.C.; Branco, A.F.; Pereira, S.L.; Parke, D.; et al. "Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells-Nuclear vs. mitochondrial effects". Biochemical Pharmacology 76 11 (2008): 1459-1475. http://www.scopus.com/inward/record.url?eid=2-s2.0-55949119796&partnerID=MN8TOARS.
    10.1016/j.bcp.2008.07.013
  58. Sardão, V.A.; Pereira, S.L.; Oliveira, P.J.. "Drug-induced mitochondrial dysfunction in cardiac and skeletal muscle injury". Expert Opinion on Drug Safety 7 2 (2008): 129-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-41349119625&partnerID=MN8TOARS.
    10.1517/14740338.7.2.129
  59. Sardão, V.A.; Oliveira, P.J.; Holy, J.; Oliveira, C.R.; Wallace, K.B.. "Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide - Characterization of morphological features of cell death". BMC Cell Biology 8 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-33947598915&partnerID=MN8TOARS.
    10.1186/1471-2121-8-11
  60. Pereira, G.C.; Branco, A.F.; Matos, J.A.C.; Pereira, S.L.; Parke, D.; Perkins, E.L.; Serafim, T.L.; et al. "Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: Comparison with direct effects on isolated mitochondrial fractions". Journal of Pharmacology and Experimental Therapeutics 323 2 (2007): 636-649. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548974344&partnerID=MN8TOARS.
    10.1124/jpet.107.128017
  61. Fiuza, S.M.; Amado, A.M.; Oliveira, P.J.; Sardão, V.A.; Batista De Carvalho, L.A.E.; Marques, M.P.M.. "Pt(II) vs Pd(II) polyamine complexes as new anticancer drugs: A structure-activity study". Letters in Drug Design and Discovery 3 3 (2006): 149-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645876182&partnerID=MN8TOARS.
    10.2174/157018006776286989
  62. Ferreira, M.; Coxito, P.M.; Sardão, V.A.; Palmeira, C.M.; Oliveira, P.J.. "Bile acids are toxic for isolated cardiac mitochondria: A possible cause for hepatic-derived cardiomyopathies?". Cardiovascular Toxicology 5 1 (2005): 63-73. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544374442&partnerID=MN8TOARS.
  63. Oliveira, P.J.; Seica, R.; Santos, D.L.; Rolo, A.P.; Sardao, V.A.; Ferreira, F.M.L.; Palmeira, C.M.; Santos, M.S.; Moreno, A.J.M.. "Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mitochondrial function in diabetic goto kakizaki rats". Mitochondrion 3 6 (2004): 337-345. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942484378&partnerID=MN8TOARS.
    10.1016/j.mito.2004.02.005
  64. Oliveira, P.J.; Rolo, A.P.; Sardão, V.A.; Monteiro, P.; Gonçalves, L.; Providência, L.A.; Palmeira, C.M.; Moreno, A.J.M.. "Advantages in the use of carvedilol versus propranolol for the protection of cardiac mitochondrial function". Revista Portuguesa de Cardiologia 23 10 (2004): 1291-1298. http://www.scopus.com/inward/record.url?eid=2-s2.0-10644236410&partnerID=MN8TOARS.
  65. Sardão, V.A.; Oliveira, P.J.; Moreno, A.J.M.. "Caffeine enhances the calcium-dependent cardiac mitochondrial permeability transition: Relevance for caffeine toxicity". Toxicology and Applied Pharmacology 179 1 (2002): 50-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037082662&partnerID=MN8TOARS.
    10.1006/taap.2001.9334
  66. Oliveira, P.J.; Rolo, A.P.; Seiça, R.; Sardão, V.; Monteiro, P.; Gonçalves, L.; Providência, L.; et al. "Impact of diabetes on induction of the mitochondrial permeability transition.". Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 21 6 (2002): 759-766. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036616238&partnerID=MN8TOARS.
  67. Oliveira, P.J.; Rolo, A.P.; Sardão, V.A.; Coxito, P.M.; Palmeira, C.M.; Moreno, A.J.M.. "Carvedilol in heart mitochondria - Protonophore or opener of the mitochondrial KATP channels?". Life Sciences 69 2 (2001): 123-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035371154&partnerID=MN8TOARS.
    10.1016/S0024-3205(01)01109-2
Thesis / Dissertation
  1. Oliveira, Vilma Marisa Arrojado Soares Sardão. "H9C2 myoblasts as a tool to study doxorubicin-induced cardiomyopathy : mechanisms of cell death and relevanceof cell differentiation". PhD, 2008. http://hdl.handle.net/10316/9633.
  2. Sardão, Vilma. "A Toxicidade da Cafeína ao Nível da Função Mitocondrial Cardíaca: Desregulação da Homeostase do Cálcio e Interacções com a Cadeia Respiratória". Degree, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2002.

Other

Other output
  1. Role of mtDNA-related mitoepigenetic phenomena in cancer. Abnormal mitochondrial function has long been associated with the development and the progression of cancer. Multiple defects in the mitochondrial genome have been reported for various cancers, however the often disregarded mitochondrial epigenetic landscape provides an additional source of deregulation that may contribute to carcinogenesis.. 2015. Ferreira, André; Serafim, Teresa L; Sardão, Vilma A; Cunha-Oliveira, Teresa. http://hdl.handle.net/10316/41108.
  2. Analysis of pro-apoptotic protein trafficking to and from mitochondria. Mitochondria play a key role in cell death and its regulation. The permeabilization of the outer mitochondrial membrane which is mainly controlled by proteins of the BCL-2 family, is a key event that can be directly induced by p53 and results in the release of pro-apoptotic factors to the cytosol, such as cytochrome c, second mitochondria derived activator of caspases/direct inhibitor-of-apoptosis. 2015. Vega-Naredo, Ignacio; Cunha-Oliveira, Teresa; Serafim, Teresa L; Sardao, Vilma A; Oliveira, Paulo J. http://hdl.handle.net/10316/41110.
  3. Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts. The cardiotoxicity induced by the anti-cancer doxorubicin involves increased oxidative stress, disruption of calcium homeostasis and activation of cardiomyocyte death. Nevertheless, antioxidants and caspase inhibitors often show little efficacy in preventing cell death. We hypothesize that a caspase-independent cell death mechanism with the release of the apoptosis-inducing factor from mitochondri. 2014. Moreira, Ana C; Branco, Ana F; Sampaio, Susana F; Cunha-Oliveira, Teresa; Martins, Tatiana R; Holy, Jon; Oliveira, Paulo J; Sardão, Vilma A. http://hdl.handle.net/10316/41109.
  4. ß-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates?. Neuro-hormonal regulation of cardiac function via cathecol-amines results in increased heart rate and contractility. A persistent adrenergic tone, however, is an insult to the heart, affecting its regular homeostasis, altering morphology and gene expression patterns, as well as inducing apoptosis of cardio-myocytes. At the same time as being the main oxygen consumers, mitochondria are also key to. 2014. Branco, Ana F; Moreira, Ana C; Cunha-Oliveira, Teresa; Couto, Renata; Sardao, Vilma A; Rizvanov, Albert A; Palotas, Andras; Oliveira, Paulo J. http://hdl.handle.net/10316/44868.
  5. Synthesis, Characterisation and Antiproliferative Studies of Allyl(dicarbonyl)(cyclopentadienyl)molybdenum Complexes and Cyclodextrin Inclusion Compounds. The complexes [(eta(5)-C5H4-CO-R)Mo(CO)(2)(eta(3)-C3H5)] [R = OH (1), Phe OMe (2)] have been examined as guests for the cyclodextrin (CD) hosts beta-CD and heptakis(2,3,6-tri-O-methyl)-beta-CD (TRIMEB), and the resultant inclusion compounds have been characterised in the solid state by elemental and thermogravimetric analyses, powder X-ray diffraction, C-13{H-1) cross-polarisation (CP) magic angle. 2014. Braga, Susana S.; Mokal, Vijaya; Almeida Paz, Filipe A.; Pillinger, Martyn; Branco, Ana F.; Sardao, Vilma A.; Diogo, Catia V.; et al. http://hdl.handle.net/10773/19837.
    10.1002/ejic.201402540
  6. Resveratrol affects differently rat liver and brain mitochondrial bioenergetics and oxidative stress in vitro: Investigation of the role of gender. Resveratrol (3,5,40-trihydroxy-trans stilbene) is commonly recognized by its antioxidant properties. Despite its beneficial qualities, the toxic effects of this natural compound are still unknown. Since mitochondria are essential to support the energy-dependent regulation of several cell functions, the objective of this study was to evaluate resveratrol effects on rat brain and liver mitochondrial. 2013. Moreira, Ana C.; Silva, Ana M.; Santos, M. S.; Sardão, Vilma A.. http://hdl.handle.net/10316/25782.
  7. Mitochondrial disruption occurs downstream from ß-adrenergic overactivation by isoproterenol in differentiated, but not undifferentiated H9c2 cardiomyoblasts: Differential activation of stress and survival pathways. ß-Adrenergic receptor stimulation plays an important role in cardiomyocyte stress responses, which may result in apoptosis and cardiovascular degeneration. We previously demonstrated that toxicity of the ß-adrenergic agonist isoproterenol on H9c2 cardiomyoblasts depends on the stage of cell differentiation. We now investigate ß-adrenergic receptor downstream signaling pathways and stress responses. 2013. Branco, Ana F.; Sampaio, Susana F.; Wieckowski, Mariusz R.; Sardão, Vilma A.; Oliveira, Paulo J.. http://hdl.handle.net/10316/26910.
  8. Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?. Mitochondria are recognized as the producers of the majority of energy cells need for their normal activity. After the initial comprehension of how mitochondrial oxidative phosphorylation produces energy, mitochondrial research was not a priority for most cell biologists until novel mitochondrial functions were identified. In fact, it is now known that mitochondria are not only involved in cell ca. 2009. Pereira, Cláudia V; Moreira, Ana C; Pereira, Susana P; Machado, Nuno G; Carvalho, Filipa S; Sardão, Vilma A; Oliveira, Paulo J. http://hdl.handle.net/10316/47550.
  9. Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targets. Abstract Doxorubicin (Dox) is a very potent antineoplastic agent used against several types of cancer, despite a cumulative cardiomyopathy that reduces the therapeutic index for treatment. H9c2 myoblast cells have been used as an in vitro model to study biochemical alterations induced by Dox treatment on cardiomyocyte cells. Despite the extensive work already published, few data are available rega. 2008. Sardão, Vilma; Oliveira, Paulo; Holy, Jon; Oliveira, Catarina; Wallace, Kendall. http://hdl.handle.net/10316/7866.
  10. Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line. Abstract Purpose Natural products represent a rich reservoir of potential small molecule inhibitors exhibiting antiproliferative and tumoricidal properties. An example is the isoquinoline alkaloid berberine, which is found in plants such as goldenseal (Hydrastis canadensis). Studies have shown that berberine is able to trigger apoptosis in different malignant cell lines, and can also lead to cell. 2008. Serafim, Teresa; Oliveira, Paulo; Sardao, Vilma; Perkins, Ed; Parke, Donna; Holy, Jon. http://hdl.handle.net/10316/7874.
  11. Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells--Nuclear vs. mitochondrial effects. http://www.sciencedirect.com/science/article/B6T4P-4T193YB-5/2/8b89adb1a424a742b294db27ed9982c6. 2008. Serafim, Teresa L.; Matos, Júlio A.C.; Sardão, Vilma A.; Pereira, Gonçalo C.; Branco, Ana F.; Pereira, Sandro L.; Parke, Donna; et al. http://hdl.handle.net/10316/10082.
  12. Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide--characterization of morphological features of cell death. Background When exposed to oxidative conditions, cells suffer not only biochemical alterations, but also morphologic changes. Oxidative stress is a condition induced by some pro-oxidant compounds, such as by tert-butylhydroperoxide (tBHP) and can also be induced in vivo by ischemia/reperfusion conditions, which is very common in cardiac tissue. The cell line H9c2 has been used as an in vitro cellu. 2007. Sardão, Vilma A.; Oliveira, Paulo J.; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.. http://hdl.handle.net/10316/12646.
  13. Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions. Berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium] is an alkaloid present in plant extracts and has a history of use in traditional Chinese and Native American medicine. Because of its ability to arrest the cell cycle and cause apoptosis of several malignant cell lines, it has received attention as a potential anticancer therapeutic agent. Previo. 2007. Pereira, Gonçalo C.; Branco, Ana F.; Matos, Júlio A. C.; Pereira, Sandro L.; Parke, Donna; Perkins, Edward L.; Serafim, Teresa L.; et al. http://hdl.handle.net/10316/12625.
  14. Pt(II) vs Pd(II) Polyamine Complexes as New Anticancer Drugs: A Structure- Activity Study. 2006. Fiuza, S.; Amado, A.; Oliveira, Paulo; Sardao, Vilma; de Carvalho, L.; Marques, M.. http://hdl.handle.net/10316/45139.
  15. Bile acids are toxic for isolated cardiac mitochondria. Abstract Cholestasis and other liver diseases may affect the heart through the toxic effects of the retained bile acids on cardiac mitochondria, which could explain the origin of hepatic-derived cardiomyopathies. The objective of this work was to test the hypothesis that bile acids are toxic to heart mitochondria for concentrations that are relevant for cholestasis. Heart mitochondria were isolate. 2005. Ferreira, Manuela; Coxito, Pedro; Sardão, Vilma; Palmeira, Carlos; Oliveira, Paulo. http://hdl.handle.net/10316/7824.
  16. Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mitochondrial function in diabetic goto kakizaki rats. The heart is one of the organs affected during the later stages of diabetes. Mitochondrial function has already been proposed to be affected during the course of diabetes. Nevertheless, little information is known concerning the impact of antioxidants in heart mitochondria of a milder model for diabetes, such as the Goto-Kakizaki (GK) rat, where mitochondrial function appears ameliorated. The obje. 2004. Oliveira, Paulo J.; Seica, Raquel; Santos, Dario L.; Rolo, Anabela P.; Sardao, Vilma A.; Ferreira, Fernanda M. L.; Palmeira, Carlos M.; Santos, Maria S.; Moreno, António J. M.. http://hdl.handle.net/10316/5391.
  17. Caffeine Enhances the Calcium-Dependent Cardiac Mitochondrial Permeability Transition: Relevance for Caffeine Toxicity. Caffeine (1,3,7-trimethylxanthine), a compound present in beverages such as tea and coffee, is known to be toxic at high concentrations. Some of the observed clinical conditions include cardiovascular disease and reproductive disorders, among others. The possible toxic effects of caffeine on heart mitochondria are still poorly understood. The influence of caffeine on the mitochondrial permeability. 2002. Sardão, Vilma A.; Oliveira, Paulo J.; Moreno, António J. M.. http://hdl.handle.net/10316/5419.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/10/25 Disruption of Lysosomal Acidification Impacts Mitochondrial Dynamics and Respiration. First International Conference on Horizontal Mitochondrial Transfer and Dynamics (HMTD)
Biocev (Prague, Czech Republic)
2023/04/11 Real-Time Cell Metabolic Analysis Using the Seahorse XF Analyzers – Technical Considerations Invited lecture within the scope of the Ph.D. Program in Experimental Biology and Biomedicine
University of Coimbra, Institute of Interdisciplinary Research (Cantanhede, Portugal)
2023/03/20 2D and 3D in vitro cell modes used in cancer research Invited lecture within the scope of the Masters Program in Molecular and Celular Biology - Cancer molecular Biology
University of Coimbra, Faculty of Sciences and Technology, Life Sciences Department (Coimbra, Portugal)
2023/03/08 The Role of the P53 Protein in cancer development Invited lecture within the scope of the Masters Program in Molecular and Celular Biology - Cancer molecular Biology
University of Coimbra, Faculty of Sciences and Technology, Life Sciences Department (Coimbra, Portugal)
2021/12/02 Basic Concepts in Cellular Metabolism
Pharmacy Student Center, Faculty of Pharmacy, University of Coimbra (Coimbra, Portugal)
2021/10/28 Mitochondrial Profiles of Lynphoblasts Obtained from ALS Patients with or without Known SOD1 mutations 12th World Congress on Targeting Mitochondria
World Mitochondria Society
2021/06/18 Exercise, Metabolism, and Mitochondria Seminário e Ciclo de Palestras CIDAF
Universidade de Coimbra, Faculdade de Ciências do Desporto e Educação Fisica (Online event, Portugal)
2021/06/12 MitoBone: Mitochondrial fitness in bone metabolism 55th Annual Scientific Meeting of European Society for Clinical Investigation
European Society for Clinical Investigation
2021/06/11 Estrogens inhibit RANKL-induced complex I activity and metabolic remodeling during the early stages of osteoclast differentiation 55TH ANNUAL SCIENTIFIC MEETING – Online Event
European Society for Clinical Investigation (Online event)
2021/06/11 Multi-dimensional Analysis of Metabolic and Mitochondrial Dysfunction Parameters in Lymphoblasts from Amyotrophic Lateral Sclerosis Patients 55th Annual Scientific Meeting of European Society for Clinical Investigation, online version
European Society for Clinical Investigation (Online event)
2021/01/20 Introduction to cell culture: fundamental principles, methods, and troubleshooting Fundamentals of Cellular and Molecular Metabolism:Relevance for Health and Disease
ITMO University, Saint Petersburg, Russia / Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
2021/01/20 Methodologies for assessing mitochondrial respiration, Fundamentals of Cellular and Molecular Metabolism:Relevance for Health and Disease
ITMO University, Saint Petersburg, Russia / Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
2020/11/20 Epidemiology of Physical Activity and Public Health - A Biochemical perspective on benefits of exercise Invited lecture within the scope of the PhD program in Sport Science,
Faculty of Sport Sciences and Physical Education, University of Coimbra (Coimbra, Portugal)
2020/09 Biological activity of brassica by-products in cell models of lipid toxicity European Journal of Clinical Investigation Virtual Meeting 2020
European Journal of Clinical Investigation
2020/09 Exploratory data analysis applied to metabolic profiling of urine-derived stem cells from young and elderly women. Annual Meeting of the European Society for Clinical Investigation, Virtual Meeting,
European Society for Clinical Investigation
2020/09 Estrogens inhibit RANKL-induced early stimulation of complex I and mitochondria function in osteoclast progenitors. Annual Meeting of the European Society for Clinical Investigation, Virtual Meeting
Annual Meeting of the European Society for Clinical Investigation
2020/07/17 Mitochondrial metabolism and sports science Lecture within the scope of the PhD program in Sport Science
Universidade de Coimbra, Faculdade de Ciências do Desporto e Educação Fisica (Coimbra, Portugal)
2019/07/10 Role of Mitochondria in bone homeostasis MiP/MitoEAGLE Training School Coimbra
University of Coimbra (Coimbra, Portugal)
2019/07/01 Methodologies for measuring mitochondrial respiration School 3 “Novel technological developments for metabolic studies”
H2020-MSCA-ITN TREATMENT GA721236, University of Coimbra (Coimbra)
2019/05/23 Delving the Bone-buried Osteocytes lipid metabolism commitment in post-menopausal osteoporosis. 53rd Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Coimbra, Portugal)
2019/01/18 From gene to protein – Evaluating the effects of environmental pollutants on biological systems Invited lecture within the scope of the Master program Ecology
, Faculty of Sciences and Technology, Department of Life Sciences, University of Coimbra (Coimbra, Portugal)
2017/10/19 Osteoporose: a perda silenciaosa Conferências no Instituto de Educação e Cidadania
Instituto de Educação e Cidadania (Mamarosa-Aveiro, Portugal)
2017/03/07 Menopause, Ostoporosis and NAFLD, CNBC/PDBEB Advanced Course: Metabolism and Disease: Causes and Consequences of Non-Alcoholic Fatty Liver Disease (NAFLD)
Center for Neuroscience and Cell Biology (Coimbra , Portugal)
2017/03/07 Viver a Menpausa sem Tabus Conferências no Instituto de Educação e Cidadania
Instituto de Educação e Cidadania (IEC) (Mamarosa-Aveiro, Portugal)
2016/12/19 Overcoming menopause effects: What can we do for it CNBC annual meeting
Center for Neuroscience and Cell Biology (CNBC) (Coimbra, Portugal)
2016/11/18 Meta”bone”lomics of post-menopausal osteoporosis CNBC Seminars
Center for Neuroscience and Cell Biology (CNBC) (Coimbra, Portugal)
2016/10/12 Osteoporose: Mecanismos, diagnóstico e formas de tratamento Jornadas de Biologia
niversity of Trás-os-Montes e Alto Douro (Vila-Real, Portugal)
2016/05/07 As maleitas da Menopausa Conversa Não Programada
Exploratório de Coimbra - Centro Ciência Viva (Coimbra, Portugal)
2015/04/25 Estradiol modulates and recovers osteocyte metabolic/lipid profiles after ovariectomy in acute and long-term in vivo hormone replacement therapeutics. 4th Joint Meeting of ECTS and IBMS
ECTS and IBMS (Rotterdam, Netherlands)
2014/12/17 24h hormone replacement therapy induced relevant osteocyte metabolic remodeling in a post-menopausal osteoporosis rat model. XVIII Congress of Portuguese Society of Biochemistry
Portuguese Society of Biochemistry (Coimbra, Portugal)
2014/11/21 Analysis of Cell Metabolism using the Seahorse Extracellular Flux Analyser – Technical Considerations Integrating Metabolimics and Cell Physiology Workshop
Center for Neuroscience and Cell Biology (Cantanhede, Portugal)
2014/04/30 Involvement of Mitochondrial Apoptosis-inducing Factor I Doxorubicin-induced Cardiotoxicity 48th Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Utrech, Netherlands)
2013/07/10 Phytoestrogens against menopausal symptoms: fighting woman nature
Department of Biology, University of Braga (Coimbra, Portugal)
2013/04/29 Phytoestrogens as alternative during hormone replacement therapy – The heroes, the villains or the useless? Natural Products: Health and Pharmaceutical Research Workshop
Escola Superior Agrária de Coimbra (Coimbra, Portugal)
2013/04/20 The increased risk of cardiovascular diseases after menopause: Young women start protecting your heart! 47th Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (ESCI) (Albufeira, Portugal)
2013/04/18 Sex Hormones and Cardiovascular Performance 47th Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical investigation (ESCI) (Albufeira, Portugal)
2013/04/17 Phytoestrogens as Potential Alternative for Hormone Replacement Therapy 47th Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Albufeira, Portugal)
2013/04/17 Post-menopausal bone loss: comparison of the metabolic profiles of bone-embedded osteocytes in normal and ovariectomized female rats 47th Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Albufeira, Portugal)
2012/06/17 Modulation of GLUT-1 expression by estrogens at the Blood Brain Barrier: a model to overcome hot flushes in menopause? Gordon Research Seminar – Barriers of CNS
(New London, New Hampshire, United States)
2011/02/02 Estrogen-Dependent Effects on Breast Cancer Cell Motility and proliferation XLI Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2010/04/30 Measuring in vitro tumor cell migration/invasion using 2D and 3D models – Applications in toxicology and drug discovery XI Jornadas de Biologia Aplicada
University of Braga (Braga, Portugal)
2009/12/02 Caspase-Independent Mechanisms in the Cytotoxicity of Doxorubicin on Embryonic Ventricular H9c2 cells XXXL Meeting of Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2007/12/05 Mechanisms of doxorubicin-Induced H9c2 myoblast death – Involvement of p53/Bax pathways and oxidative stress XXXVIII Meeting of Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2006/12/05 The H9c2 Cell Line as a Model For Drug-Induced Alterations on Cardiac Cells: Morphologic Alterations Induced by Doxorubicin Exposure XXXVII Meeting of Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto)
2006/09/06 Morphological Endpoints of Cell Death Upon Exposure of H9c2 Embryonic Ventricular Cells to tert-butylhydroperoxide 4th Annual meeting of the Society for Heart and Vascular Metabolism
(Semiahmoo, WA, United States)
2005/12/13 Adriamycin-induced cardiomyopathies: role and mechanisms of mitochondrial dependent and independent cell death Research Seminars for 2005-2006,
University of Minnesota, Medical School – Duluth Campus (Duluth, United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/10/01 - Current Effect of lifelong exercise in the immune system and in the prevention of colon cancer: role of mitochondria
Co-supervisor of Ana Rita Vieira Pedrosa
 Doctorate Program in Sport Sciences (PhD)
Universidade de Coimbra Faculdade de Ciências do Desporto e Educação Física, Portugal
2019 - 2023/06/13 mitoBone: Mitochondrial performance on osteoclast differentiation and function during E2 deprivation - Finding new targets for osteoporosis treatment
Supervisor of Adriana Marques Carvalho
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019 - 2020 Biological activity of Brassica by-products in cell models of lipid toxicity
Supervisor of José Pedro Fernandes Castelão Moreira Baptista
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2020 Orchestrating Osteoclast Differentiation Through ROS and Mitochondrial Regulation: Developing new approaches for osteoporosis treatment
Supervisor of Sara Inês Furtado Canário
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 - 2020 Menopause vs. Osteoporosis – The role of phytoestrogens on bone remodeling and their antiosteoporetic effects
Supervisor of Ana Maria Pereira da Silva
 Doutoramento em Biociências (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2019 Mitochondrial Performance During Osteoblast Differentiation - Searching New Targets to Counteract Osteoporosis
Supervisor of Sara Cristiana Alves Valente
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2017 Analysis of mitochondrial respiratory chain proteins and sirtuin 3 in brain homogenates from ovariectomized rats in the presence and absence of estradiol and the phytoestrogen coumestrol, by the western blot method.
Supervisor of Joana Faria
 Biologia Humana (Degree)
Universidade de Évora, Portugal
2016 - 2017 Células estaminais derivadas da urina: Análise metabólica e tentativa de optimização do processo de crescimento celular
Supervisor of José Pedro Fernandes Castelão Moreira Baptista
 Bioquímica (Degree)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 - 2014 Protection Provided by Phytoestrogens against Cardiac Lipotoxicity Induced by Palmitic Acid
Supervisor of Renata Lopes Familiar Couro
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 - 2014 Prevention of Cardiac Lipotoxicity Induced by Palmitic Acid by the phytoestrogen Coumestrol
Supervisor of Francisca Goulão Mora
 Bioquímica (Degree)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/09/01 - 2013/12 Phytoestrogens as Alternative to the Hormone Replacement Therapy: Cellular and Mitochondrial Interactions
Co-supervisor of Ana Carolina dos Santos Moreira
 Biociências (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/09 - 2010/06 Avaliação Toxicológica de Fitoestrogénios em mitocôndrias cardíacas
Co-supervisor of Estela Filipa dos Santos Alves
 Bioquímica
Universidade de Évora Escola de Ciências e Tecnologia, Portugal
2008 - 2009 Caspase-Independent Mechanism in the Cytotoxicity of Doxorubicin on Embryonic Ventricular H9c2 Cells
Co-supervisor of Ana Carolina dos Santos Moreira
 Biologia (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/06/09 - 2021/06/11 Symposium Mitochondria in Health and Disease, in the 55th Annual Scientific Meeting of the European Society for Clinical Investigation, Online Event (2021/06/10 - 2021/06/11)
Symposium (Co-organisor)
 European Society for Clinical Investigation, Netherlands
2021/06/09 - 2021/06/09 Pre-meeting Course in the 55th Annual Scientific Meeting of European Society for Clinical Investigation on Cell respirometry. (2021/06/09 - 2021/06/09)
Workshop (President of the Organising Committee)
 European Society for Clinical Investigation, Netherlands
2019/09/01 - 2019/09/06 Second edition of FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, (2019/09/01 - 2019/09/06)
Congress
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Federation of European Biochemical Societies, United Kingdom
2018/11/01 - 2019/05/24 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI2019) (2019/05/22 - 2019/05/24)
Congress (Member of the Organising Committee)
 European Society for Clinical Investigation , Netherlands
2019/02/01 - 2019/05/22 Mitochondrial and Cellular Respirometry - Pre-congress course in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (2019/05/22 - 2019/05/22)
Workshop (Co-organisor)
 European Society for Clinical Investigation , Netherlands
2017/06/18 - 2017/06/24 FEBS Advanced Lecture Course on Oncometabolism – From Conceptual Knoeledge to Clinical Applications, in Figueira da Foz, Portugal (2017/06/18 - 2017/06/24)
Congress (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Federation of European Biochemical Societies, United Kingdom
2016/04/11 - 2016/04/15 Cell Respirometry: Basics and Applications (2016/04/11 - 2016/04/15)
Workshop (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/02/02 - 2015/02/03 Cancer Epigenetics and Metabolism: Connecting the Dots (2015/02/02 - 2015/02/03)
Workshop (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/12/17 - 2014/12/20 XVIII Congress of the Portuguese Biochemical Society (SPB) (2014/12/17 - 2014/12/20)
Congress (Member of the Organising Committee)
 Sociedade Portuguesa de Bioquímica, Portugal
2013/04/17 - 2013/04/20 Symposium in the 47th Annual Meeting of the European Society for Clinical Investigation (ESCI), in Albufeira, Portugal. Workshop title: “Pathophysiology of menopause: more than just aging?” (2013/04/17 - 2013/04/20)
Symposium (Member of the Organising Committee)
 European Society for Clinical Investigation, Netherlands
2010/05/11 - 2010/05/14 Survival or Death as a Matter of Fat, International Courses on Toxicology (2010/05/11 - 2010/05/14)
Congress (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/05/05 - 2009/05/09 Mitochondria: Between Life and Death (International Courses on Toxicology) (2009/05/05 - 2009/05/09)
Congress (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/04/09 - 2008/04/11 Metabolic Toxicology, From Pathway to Organism (International Courses on Toxicology) (2008/04/09 - 2008/04/11)
Congress (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2006/03/22 - 2006/03/24 Smart Toxicology: Subcellular Targets of Anti-cancer Therapy (International Courses on Toxicology) (2006/03/22 - 2006/03/24)
Congress (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/09/24 - 2020/09/24 Introduction to Data Management Plans - online course
Workshop
 Introduction to Data Management Plans
BioData.pt, Portugal
2015/02/15 - 2015/03/20 Participant in the entrepreneurship Courses "ineoStart Business Acceleration Programme"
Call
 ineoStart Business Acceleration Programme
Universidade de Coimbra - Instituto Pedro Nunes, Portugal
2010/04/19 - 2010/04/30 Participant in the course "Introduction to Laboratory Animal Science - FELASA Cat C"
Other
 Introduction Laboratory Animal Science - FELASA Cat C
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2009/10/26 - 2009/10/28 Participant in the course "The second genome: mitochondrial genetics – fromgenotype to phenotype and clinical expression"
Other
 The second genome: mitochondrial genetics – fromgenotype to phenotype and clinical expression
Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/08/21 - 2009/08/30 Participant in the "18th Annual Short Course on Experimental Models of Human Cancer"
Other
 18th Annual Short Course on Experimental Models of Human Cancer
Howard Hughes Medical Institute - The Jackson Laboratory, United States
2005/04/27 - 2005/04/29 Participant in the course "Mitochondria: Between Life and Death"
Other
 Mitochondria: Between Life and Death
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2003/01/12 - 2003/01/16 Participant in the course "Biology of cell death II: Apoptosis Regulation"
Other
 Biology of cell death II: Apoptosis Regulation
Universidade de Lisboa Faculdade de Farmácia, Portugal
2002/10/08 - 2002/10/11 Participant in the short Course "Competence management and Personal Valorization", organized by School of Science and Technology of University of Coimbra
Other
 Competence management and Personal Valorization
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2002/10/04 - 2002/10/06 Participant in the "Bioenergetics: The Cellular Power Plants", the 4th Short Course organized by the of Portuguese Biophysical Society
Other
 Bioenergetics: The Cellular Power Plants
Sociedade Portuguesa de Bioquímica, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/06/13 MitoBone: Mitochondrial performance on osteoclast differentiation and function during E2 deprivation - Finding new targets for osteoporosis treatment
Supervisor
 Adriana Marques Carvalho (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020/12/21 Chronic inflammatory cartilage biomarkers in athletes from different sports. Interpreting acute and chronic response to exercise from several inflammatory biomarkers: a review; Correlation between chronic inflammatory biomarkers in male athletes from ultra-running, rugby and cross-training.
(Thesis) Main arguer
 Pedro Afonso da Silva Valente (Master)
Universidade de Coimbra Faculdade de Ciências do Desporto e Educação Física, Portugal
2020/12/04 Biological activity of Brassica by-products in cell models of oxidative stress and lipid toxicity
Supervisor
 José Pedro Fernandes Castelão Moreira Baptista (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2020/02/27 Orchestrating Osteoclast Differentiation Through ROS and Mitochondrial Regulation: Developing new approaches for osteoporosis treatment
Supervisor
 Sara Inês Furtado Canário (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/09/10 Mitochondrial Performance During Osteoblast Differentiation – Searching New Targets to Counteract Osteoporosis
Supervisor
 Sara Cristina Valente Dos Santos (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09/13 The importance of cytokines-mediated communication in CSCs’ formation
(Thesis) Main arguer
 Marco Rafael Lopes da Cunha (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09/09 Tracking of the intracellular cytokines’transduced signals
(Thesis) Arguer
 Eurico da Silva Serrano (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015 New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models
(Thesis) Main arguer
 Ana Filipa Fernandes Ferreira Sobral (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 Desenvolvimento de uma nova estratégia terapêutica para cancro da mama, envolvendo a acção combinada de terapia génica e quimioterapia.
(Thesis) Main arguer
 Gabriela de Jesus Leão Pereira dos Santos (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 Bacterial protein azurin as a new candidate anticancer drug by decreasing cell adhesion through integrins
(Thesis) Main arguer
 Sofia de Almeida Santos de Castro e Abreu (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 Phytoestrogens as Alternative to the Hormone Replacement Therapy: Mitochondrial and Cellular Interactions
Supervisor
 Ana Carolina dos Santos Moreira (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/11/26 Análise proteómica das fracções subcelulares de uma linha cellular de neuroblastomas humanos.
(Thesis) Main arguer
 Stella Tatiana Liahuca de Esteves (Master)
Universidade de Lisboa Instituto Superior de Agronomia, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/11/01 - 2022/01/20 Independent Study in Exercise Physiology and Laboratory Practice - Estudo Independente em Fisiologia do Exercício e Prática Laboratorial (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Faculdade de Ciências do Desporto e Educação Física, Portugal
2020/03/01 - 2021/06/30 Biochemistry of the exercise - Bioquímica do Exercício Ciências do Desporto (Licenciatura) Universidade de Coimbra Faculdade de Ciências do Desporto e Educação Física, Portugal

Interview (tv / radio show)

Program Topic
2015/07/28 - Current Mentes que Brilham - Porto Canal Osteoporosis - Bone Metabolism

Journal scientific committee

Journal title (ISSN) Publisher
2020/01/12 - Current Journal of Visualized Experiments (1940-087X) MyJoVE Corporation
2019/09 - Current Toxicology in Vitro (0887-2333) Elsevier
2019/09 - Current Mitochondrion (1567-7249) Elsevier
2019/07/28 - Current Journal of Endocrinology (1479-6805) Bioscientifica
2019/05/31 - Current Frontiers in Pharmacology (1663-9812) Frontiers Media SA
2019/02 - Current Molecules (1420-3049) MDPI AG
2018/09 - Current Nutrients (2072-6643) MDPI AG
2018/06 - Current PeerJ (2167-8359) PeerJ
2018/06 - Current Biochemical Pharmacology (0006-2952) Elsevier
2018/03/01 - Current Journal of Functional Foods (1756-4646) Elsevier
2017/12 - Current Scientific Reports (2045-2322) Springer Science and Business Media LLC
2017/11 - Current Life Sciences (0024-3205) Elsevier
2017/09/26 - Current Biology of Sex Differences (2042-6410) Springer (Biomed Central Ltd.)
2017/09/04 - Current International Journal of Reproductive Medicine & Gynecology (2314-5757) Hindawi Limited
2017/06/07 - Current Journal of Cellular Biochemistry (1097-4644) Wiley (John Wiley & Sons)
2017/03/17 - Current Journal of Functional Foods (1756-4646) Elsevier
2015/08 - Current Toxicology Elsevier
2014/07 - Current Marine Drugs (1660-3397) MDPI AG
2014/02/24 - Current Journal of Pharmacy and Pharmacology (2042-7158) Wiley (Blackwell Publishing)
2013/12/10 - Current Free Radical Research (1029-2470) Informa UK (Taylor & Francis)
2013/05/10 - Current Anti-Cancer Agents in Medicinal Chemistry (1871-5206) Bentham Science
2012/08/05 - Current Journal of Clinical Toxicology (2161-0495) OMICS Publishing Group
2012/07/26 - Current International Journal of Molecular Sciences (1422-0067) MDPI AG
2012/07 - Current Oxidative Medicine and Cellular Longevity (1942-0994) Hindawi Limited
2012/05 - Current Neurotoxicity Research (1476-3524) Springer-Verlag
2012/03/28 - Current Chemotherapy (1421-9794) S. Karger AG
2012/02 - Current Toxicology and Applied Pharmacology (1096-0333) Elsevier
2012/01/11 - Current European Journal of Medicinal Plants (2231-0894) Sciencedomain International
2010/05/17 - Current Current Drug Targets (1389-4501) Bentham Science
2009/09/09 - Current Free Radical Biology and Medicine (0891-5849) Elsevier

Mentoring / Tutoring

Topic Student name
2017/01 - 2017/06 Cellular Biology Joana Faria
2017/01 - 2017/06 Cellular Biology José Baptista
2015/01 - 2015/06 Cellular Biology Cátia Seabra
2015/01 - 2015/06 Cellular Biology Nuno Beltrão
2014/09 - 2014/12 Mitochondrial physiology Francisca Moura
2013/01 - 2013/06 Mitochondria physiology Ana Oliveira
2009 - 2010 Mitochondrial physiology Estela Alves
2006 - 2007 Cellular Biology Ana Filipa Branco
Distinctions

Award

2015 New Investigator Award for an Outstanding Work
2014 Outstanding communication
2006 Graduate Student/Postdoc Award for Presentation of Scientific Work
2004 Best Young Researcher in Basic Research
Sociedade Portuguesa de Cardiologia, Portugal
2003 Award Aventis for Scientific Research
2002 Prize for Merit from University of Coimbra
Universidade de Coimbra, Portugal

Other distinction

2003 PRODEP III (Education Operational Program III)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal