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Ana Raquel Nunes completed her MSc Degree on Biomedical Sciences at the University of Beira Interior, Covilhã, Portugal. She is presently a PhD student in Biomedicine, at Health Sciences Research Center (CICS-UBI), University of Beira Interior, Covilhã, Portugal. Her main research interests focus on extracting phenolic compounds of natural products and evaluate their biological activities, namely those related to the antioxidant, andiabetic and antiinflammatory activity. The present research interests include the impact and mechanism of action of phenolics of by-products of Prunus avium L. (Sweet Cherry) in oxidative stress-related diseases. She develops her research within the CICS-UBI subgroup team NatProMicro - Natural Products & Microbial Research.
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Identification

Personal identification

Full name
Ana Raquel Mendes da Paula Nunes

Citation names

  • Nunes, AR
  • Ana R. Nunes
  • Ana Raquel Nunes

Author identifiers

Ciência ID
AF15-4DFE-CA7B
ORCID iD
0000-0001-6847-5764
Scopus Author Id
56531494300

Email addresses

  • d2428@ubi.pt (Professional)
  • araqueln@gmail.com (Personal)

Addresses

  • Centro de investigação em Ciências da Saúde, Universidade da Beira Interior (CICS-UBI) - Faculdade de Ciências da Saúde (FCS). Av. Infante D. Henrique, 6200-506, Covilhã, Covilhã, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences - Nutrition, Dietetics
  • Natural sciences - Biological Sciences - Plant sciences
  • Medical and Health Sciences - Clinical Medicine - Endocrinology and Metabolism
  • Agrarian Sciences - Agrarian and Food Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Beginner (A1) Elementary (A2) Elementary (A2) Elementary (A2)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Portuguese (Mother tongue)
Education
Degree Classification
2019/01/01 - 2025
Ongoing
 Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal

Universidade de Coimbra, Portugal
2014
Concluded
 Ciências Biomédicas (Mestrado)
Universidade da Beira Interior, Portugal
"Effect of de Daily Consumption of White Tea in Cerebral Cortex of Prediabetic Rats" (THESIS/DISSERTATION)
 17
2012
Concluded
 Ciências Biomédicas (Licenciatura)
Universidade da Beira Interior, Portugal
 13
Affiliation

Science

Category
Host institution 		Employer
2018/03/01 - 2018/12/31 Researcher (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Other Careers

Category
Host institution 		Employer
2021/11/02 - 2023/11/01 Técnico Superior (Técnico Superior) Universidade da Beira Interior, Portugal
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Others

Category
Host institution 		Employer
2019/01/01 - Current PhD Student Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2020/04 - 2020/07 Volunteer at 'Laboratório COVID-19' Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Projects

Grant

Designation Funders
2019/01/01 - Current Prunus avium L. vegetal parts and their bioactive properties in health and disease: What is the impact of the unexplored cherry byproducts?
SFRH/BD/139137/2018
PhD Student Fellow
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Hospitais da Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/03/01 - 2019/12/31 CMeC: Cereja do Fundão confitada com mel e carqueja como promotora da saúde
CENTRO-01-0247-FEDER-017547
Research Fellow
Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
 FEDER - Fundo Europeu de Desenvolvimento Regional

CENTRO 2020 - Programa Operacional Regional do Centro
Concluded
Outputs

Publications

Book chapter
  1. Silva, BM; Tomás, GD; Nunes, AR; Ramalhosa, E; Pereira, JA; Alves, MG; Oliveira, PF. "Phytochemical, Nutritional, Antioxidant and Anticancer Properties of Juglans regia (L.)". In Natural Bioactive Compounds from Fruits and Vegetables as Health Promoters Part II, 110-131. Berlin, Germany: BENTHAM SCIENCE PUBLISHERS, 2016.
    10.2174/9781681082431116010008
  2. Nunes, AR; Alves, MG; Oliveira, PF; Silva, LR; Silva, BM. "Bioactive Compounds and Health-Promoting Properties of Ficus carica (L.): A Review". In Natural Bioactive Compounds from Fruits and Vegetables as Health Promoters Part I, 3-28. BENTHAM SCIENCE PUBLISHERS, 2016.
    10.2174/9781681082394116010004
  3. Nunes, AR; Alves, MG; Moreira, PI; Oliveira, PF; Silva, BM. "Impact of Green Tea (Camellia sinensis L.) Consumption in Diabetes Mellitus-Induced Neurodegeneration". In Green Tea and Health: Antioxidant Properties, Consumption and Role in Disease Prevention. New York, United States: Nova Science Publishers, Inc, 2015.
    Published
Conference poster
  1. Nunes, AR; Gonçalves, AC; Jesus, F; Falcão, A; Silva, LR; Alves, G.. "Phytochemical profile and bioactive properties of Prunus avium (L.) stems: A cost effective strategy for health improvement?". Paper presented in Natural Products in Drug Discovery and Human Health (NatProdDDH), Lisbon, Portugal, 2019.
  2. Gonçalves, AC; Bento, C; Nunes, AR; Alves, G.; Silva, LR. "Phenolic rich extracts of sweet cherry: antioxidant activity, antidiabetic potential and erythrocytes protection". Paper presented in 30th International Symposium on the Chemistry of Natural Products, Athens, Italy, 2018.
  3. Nunes, AR; Gonçalves, AC; Jesus, F; Alves, G.; Silva, LR. "Prunus avium (L.) stems as a good therapeutic potential for human health". Paper presented in 30th International Symposium on the Chemistry of Natural Products, Athens, Italy, 2018.
  4. Nunes, AR; Jesus, F; Gonçalves, AC; Alves, G.; Silva, LR. "Effects of phenolic compounds from Prunus avium leaves in Caco-2 cells against t-BHP-induced toxicity". Paper presented in 4th International Congress on Occupational & Environmental Toxicology, Matosinhos, Porto, Portugal, 2018.
  5. Gonçalves, AC; Nunes, AR; Rodrigues, Márcio; O. Santos, A.; Alves, G.; Silva, LR. "Effects of sweet cherry phenolics on human colon adenocarcinoma Caco-2 cells". Paper presented in 4th International Congress on Occupational & Environmental Toxicology, Matosinhos, Porto, Portugal, 2018.
  6. Gonçalves, AC; Nunes, AR; Rodrigues, Márcio; O. Santos, A.; Alves, G.; Silva, LR. "Effects of coloured and non-coloured phenolics of Saco sweet cherries on human colon adenocarcinoma Caco-2 cells". Paper presented in XIII Annual CICS Symposium, Covilhã, Portugak, 2018.
  7. Silva, LR; Gonçalves, AC; Nunes, AR; Bento, C; Alves, G.. "Pterospartum tridentatum: the biological potential of phenolic compounds". Paper presented in XIII Annual CICS Symposium, Covilhã, Portugal, 2018.
  8. Gonçalves, AC; Nunes, AR; Rodrigues, Márcio; Alves, G.; Silva, LR. "The anticarcinogenic effect of Saco sweet cherry extracts on human colon adenocarcinoma Caco-2 cell lines". Paper presented in II Reunião de Oncologia da Cova da Beira, Centro Hospitalar Universitário Cova da Beira, 2018.
  9. Silva, LR; Gonçalves, AC; Nunes, AR; Alves, G.. "The viability effects of phenolics from Pterospartum tridentatum on human colon adenocarcinoma". Paper presented in II Reunião de Oncologia da Cova da Beira, Centro Hospitalar Universitário Cova da Beira, 2018.
  10. Nunes, AR; Gonçalves, AC; Alves, G.; Silva, LR. "Prunus avium vegetal parts: Can stems be a good therapeutic potential against cancer cells?". Paper presented in II Reunião de Oncologia da Cova da Beira, Centro Hospitalar Universitário Cova da Beira, Covilhã, Portugal, 2018.
  11. Silva, BM; Alves, MG; Nunes, AR; Moreira, PI; Oliveira, PF. "White tea consumption improves heart and brain glycolytic and oxidative profiles in prediabetic rats". Paper presented in 63th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Budapest, Hungry, 2015.
  12. Alves, MG; Conde, VR; Nunes, AR; Ramalhosa, E; Pereira, JA; Oliveira, PF; Silva, BM. "Metabolic alterations associated with bladder cancer progression". Paper presented in X Annual CICS Symposium, Covilhã, Portugal, 2015.
  13. Nunes, AR; Alves, MG; Dias, TR; Cristóvão, AC; Moreira, PI; Oliveira, PF; Silva, BM. "White tea consumption: a cost effective strategy to prevent prediabetes-related effects in heart and brain?". Paper presented in X Annual CICS Symposium, Covilhã, Portugal, 2015.
Journal article
  1. Nunes, Ana R.; Costa, Elisabete C.; Alves, Gilberto; Silva, Luís R.. "Nanoformulations for the Delivery of Dietary Anthocyanins for the Prevention and Treatment of Diabetes Mellitus and Its Complications". Pharmaceuticals 16 5 (2023): 736. http://dx.doi.org/10.3390/ph16050736.
    10.3390/ph16050736
  2. Nunes, Ana R.; Flores-Félix, José D.; Gonçalves, Ana C.; Falcão, Amílcar; Alves, Gilberto; Silva, Luís R.. "Anti-Inflammatory and Antimicrobial Activities of Portuguese Prunus avium L. (Sweet Cherry) By-Products Extracts". Nutrients 14 21 (2022): 4576. http://dx.doi.org/10.3390/nu14214576.
    10.3390/nu14214576
  3. Gonçalves, Ana C.; Nunes, Ana R.; Flores-Félix, José D.; Alves, Gilberto; Silva, Luís R.. "Cherries and Blueberries-Based Beverages: Functional Foods with Antidiabetic and Immune Booster Properties". Molecules 27 10 (2022): 3294. http://dx.doi.org/10.3390/molecules27103294.
    Accepted • 10.3390/molecules27103294
  4. Nunes, Ana R.; Gonçalves, Ana C.; Pinto, Edgar; Amaro, Filipa; Flores-Félix, José D.; Almeida, Agostinho; Guedes de Pinho, Paula; et al. "Mineral Content and Volatile Profiling of Prunus avium L. (Sweet Cherry) By-Products from Fundão Region (Portugal)". Foods 11 5 (2022): 751. http://dx.doi.org/10.3390/foods11050751.
    10.3390/foods11050751
  5. Gonçalves, Ana C.; Rodrigues, Márcio; Flores-Félix, José David; Campos, Gonçalo; Nunes, Ana R.; Ribeiro, Alessandra Braga; Silva, Luís R.; Alves, Gilberto. "Sweet cherry phenolics revealed to be promising agents in inhibiting P-glycoprotein activity and increasing cellular viability under oxidative stress conditions: in vitro and in silico study". Journal of Food Science 87 1 (2021): 450-465. http://dx.doi.org/10.1111/1750-3841.16001.
    10.1111/1750-3841.16001
  6. Nunes, Ana R.; Gonçalves, Ana C.; Falcão, Amílcar; Alves, Gilberto; Silva, Luís R.. "Prunus avium L. (Sweet Cherry) By-Products: A Source of Phenolic Compounds with Antioxidant and Anti-Hyperglycemic Properties—A Review". Applied Sciences 11 18 (2021): 8516. http://dx.doi.org/10.3390/app11188516.
    10.3390/app11188516
  7. Gonçalves, Ana C.; Nunes, Ana R.; Falcão, Amílcar; Alves, Gilberto; Silva, Luís R.. "Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review". Pharmaceuticals 14 7 (2021): 690. http://dx.doi.org/10.3390/ph14070690.
    10.3390/ph14070690
  8. Gonçalves, Ana C.; Nunes, Ana R.; Falcão, Amílcar; Alves, Gilberto; Silva, Luís R.. "Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review". Pharmaceuticals 14 7 (2021): 690. http://dx.doi.org/10.3390/ph14070690.
    Published • 10.3390/ph14070690
  9. Nunes, Ana R.; Gonçalves, Ana C.; Alves, Gilberto; Falcão, Amílcar; Garcia-Viguera, Cristina; A. Moreno, Diego; Silva, Luís R.. "Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability". Foods 10 6 (2021): 1185. http://dx.doi.org/10.3390/foods10061185.
    10.3390/foods10061185
  10. Ana C. Gonçalves; Ana R. Nunes; Gilberto Alves; Luís R. Silva. "Serotonin and Melatonin: Plant Sources, Analytical Methods, and Human Health Benefits". Revista Brasileira de Farmacognosia (2021): https://doi.org/10.1007/s43450-021-00141-w.
    10.1007/s43450-021-00141-w
  11. Silva, LR; Gonçalves, AC; Nunes, AR; Alves, G.. "Authentication of honeys from Caramulo region (Portugal): Pollen spectrum, physicochemical characteristics, mineral content, and phenolic profile". Journal of Food Science 85 2 (2020): 374-385. http://dx.doi.org/10.1111/1750-3841.15023.
    Published • 10.1111/1750-3841.15023
  12. Nunes, AR; Alves, MG; Dias, TR; Cristóvão, AC; Moreira, PI; Oliveira, PF; Silva, BM. "White tea consumption improves the glycolytic and oxidative profiles of cerebral cortex of prediabetic Wistar rats: a possible role for neuroprotection?". Medicine 95 10 (2016): e02371. http://dx.doi.org/10.1097/md.0000000000002371.
    Published • 10.1097/md.0000000000002371
  13. Conde VR; Oliveira PF; Nunes AR; Rocha CS; Ramalhosa E; Pereira JA; Alves MG; Silva BM. "The progression from a lower to a higher invasive stage of bladder cancer is associated with severe alterations in glucose and pyruvate metabolism.". (2015): http://europepmc.org/abstract/med/25907297.
    10.1016/j.yexcr.2015.04.007
  14. Nunes, A.R.; Alves, M.G.; Tomás, G.D.; Conde, V.R.; Cristóvão, A.C.; Moreira, P.I.; Oliveira, P.F.; Silva, B.M.. "Daily consumption of white tea (Camellia sinensis (L.)) improves the cerebral cortex metabolic and oxidative profile in prediabetic Wistar rats". British Journal of Nutrition 113 5 (2015): 832-842. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926409736&partnerID=MN8TOARS.
    10.1017/S0007114514004395
  15. Nunes, A.R.; Alves, M.G.; Moreira, P.I.; Oliveira, P.F.; Silva, B.M.. "Can tea consumption be a safe and effective therapy against diabetes mellitus-induced neurodegeneration?". Current Neuropharmacology 12 6 (2014): 475-489. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924963252&partnerID=MN8TOARS.
Thesis / Dissertation
  1. Nunes, AR. "Effect of de Daily Consumption of White Tea in Cerebral Cortex of Prediabetic Rats". Master, Universidade da Beira Interior, 2014.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/11 Sweet cherries phenolic-rich fractions exhibit anti-cancer properties and can modulate P-glycoprotein activity III International Congress in Health Sciences Research Towards Innovation and Entrepreneurship: Trends in Aging and Cancer
CICS - UBI Doctoral Students Committee (Covilhã, Portugal)
2019/07 Phenolic composition, minerals and biological potential of Saco sweet cherry. Natural Products in Drug Discovery and Human Health (NatProdDDH)
Royal Society of Chemistry (Lisboa, Portugal)
2018/08 The biological potential of phenolic compounds from Prunus avium L. stems XIII Annual CICS Symposium
(C, Portugal)
2018/07 Physicochemical characteristics, chemical constituents and health-promoting properties of sweet cherries from Fundão region (Portugal) XIII Annual CICS Symposium
(Co, Portugal)
2016/07 Polyphenols as protective agents against neurotoxicity and neurodegeneration: the case of tea polyphenols ISANH Porto Polyphenols World Congress
ISEP (Porto, Portugal)
2016/03 Polyphenols and Neurodegeneration: Is White Tea Consumption an Efficient Therapy Against Brain Damage Induced by Prediabetes? UMIB Post-Graduates Scientific Seminars
Instituto de Ciências Biomédicas Abel Salazar (Porto, Portugal)
2015/09 White Tea Consumption Improves the Glycolytic and Oxidative Profiles of Cerebral Cortex of Prediabetic Wistar Rats: A Possible Role for Neuroprotection? UMIB Summit 2015
Instituto de Ciências Biomédicas Abel Salazar (Porto, Portugal)
2015/08 White tea consumption improves heart and brain glycolytic and oxidative profiles in prediabetic rat 63th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research
(Budapest, Hungary)
2015/03 The chemistry of tea: white tea and prediabetes VII Congresso de Análises Clínicas e Saúde Pública
Instituto Politécnico de Castelo Branco (Castelo Branco, Portugal)
2014/07 Bladder cancer progression is associated with alterations of bladder cells glycolytic profile IX Annual CICS Symposium
(Covilhã, Portugal)
2014/07 Effect of the daily consumption of white tea in the cerebral cortex of prediabetic rats IX Annual CICS Symposium
(Covilhã, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2011/03 - Current II Jornadas Nacionais em Ciências Biomédicas (2011/03/03 - 2011/03/05)
Congress (Member of the Organising Committee)
 Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2019/11/14 - 2019/11/16 III Congress in Health Sciences Research: Towards Innovation and Entrepreneurship Trends in Aging and Cancer (2019/11/14 - 2019/11/16)
Congress (Member of the Organising Committee)
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Committee member

Activity description
Role 		Institution / Organization
2018 - Current PhD students committee
Member
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2015 - 2015 Human Molecular Genetics Ciências Biomédicas (Mestrado integrado) Universidade da Beira Interior, Portugal
2014 - 2014 Human Molecular Genetics Ciências Biomédicas (Mestrado integrado) Universidade da Beira Interior, Portugal

Mentoring / Tutoring

Topic Student name
2015/07 - 2015/08 Co-supervisor of summer internship student Mariana Reis
Distinctions

Award

2016 Editor’s Choice - “Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration?"
Current Neuropharmacology, Italy
2016 Best Join Paper 2015 - "Daily consumption of white tea (Camellia sinensis (L.)) by prediabetic Wistar rats improves cerebral cortex metabolic and oxidative profile"
VWR International, United Kingdom