Curriculum Vitae
Ana Luísa Ferro Espadanal Torres de Magalhães Canha
Identification
Personal identification
- Full name
- Ana Luísa Ferro Espadanal Torres de Magalhães Canha
Citation names
- Ana Magalhães
Author identifiers
- Ciência ID
- B01A-25D3-D498
Languages
| Language | Speaking | Reading | Writing | Listening | Peer-review |
|---|---|---|---|---|---|
| English | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) | |
| French | Intermediate (B1) | Intermediate (B1) | Intermediate (B1) | Intermediate (B1) | |
| Spanish; Castilian | Advanced (C1) | Advanced (C1) | Intermediate (B1) | Advanced (C1) |
Education
| Degree | Classification | |
|---|---|---|
|
2010/07/13
Concluded
|
Biologia Celular (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
Memorial Sloan Kettering Cancer Center, United States "Analysis of the PRK family of Rho GTPase effector proteins in the context of cell cycle progression and epithelial morphogenesis" (THESIS/DISSERTATION)
|
Aprovado com Distinção e Louvor |
|
2003
Concluded
|
Biologia - Ramo Científico (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Estudo da contribuição de proteínas fágicas na lise de Streptococcus pneumoniae (tese de estágio)" (THESIS/DISSERTATION)
|
16 |
Affiliation
Science
| Category Host institution |
Employer | |
|---|---|---|
| 2024/11/01 - Current | Postdoc (Research) | Gulbenkian Institute for Molecular Medicine, Portugal |
| Gulbenkian Institute for Molecular Medicine, Portugal | ||
| 2020/08/01 - 2024/07/31 | Postdoc (Research) | Instituto de Medicina Molecular João Lobo Antunes, Portugal |
| Instituto de Medicina Molecular João Lobo Antunes, Portugal | ||
| 2012/10/01 - 2020/07 | Postdoc (Research) | Fundação para a Ciência e a Tecnologia, Portugal |
| Instituto de Medicina Molecular João Lobo Antunes, Portugal | ||
| 2010/05/01 - 2012/09/30 | Postdoc (Research) | Fundação para a Ciência e a Tecnologia, Portugal |
| Instituto Português de Oncologia de Coimbra Francisco Gentil EPE, Portugal (...) |
||
| 2006/04/01 - 2010/04/01 | Visiting Researcher (Research) | Fundação para a Ciência e a Tecnologia, Portugal |
| Memorial Sloan Kettering Cancer Center, United States (...) |
||
| 2004/10/01 - 2006/04/01 | Visiting Researcher (Research) | Fundação para a Ciência e a Tecnologia, Portugal |
| MRC Laboratory for Molecular Cell Biology, United Kingdom | ||
| 2002/11/01 - 2003/10/01 | Research Trainee (Research) | Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal |
| Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal | ||
| 2002/02/01 - 2002/06/01 | Visiting Researcher (Research) | Laboratoire de Biologie Moléculaire des Eucaryotes, France |
| Laboratoire de Biologie Moléculaire des Eucaryotes, France |
Projects
Contract
| Designation | Funders | |
|---|---|---|
| 2018/01/01 - Current | How does cholesterol promote breast cancer metastasis (lipidmets).
PTDC/SAU-ONC/114080/2017
Researcher
Instituto de Medicina Molecular João Lobo Antunes, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
| 2024/01/01 - 2025/01/31 | A 3D tumor-on-chip platform to identify drugs that block CTC release
Human-based models as drug discovery tools
Principal investigator
Gulbenkian Institute for Molecular Medicine, Portugal
|
Instituto de Medicina Molecular João Lobo Antunes
Ongoing
|
| 2020/08/01 - 2022/07/31 | Regulation of Breast Cancer Intravasation
Laço Research Grant 2019
Principal investigator
Instituto de Medicina Molecular João Lobo Antunes, Portugal
|
Fundo iMM Laço
Ongoing
|
| 2016/01/01 - 2018/12/31 | Cell-cell communication in metastatic breast cancer: a control point that can lead to breast cancer treatment
PTDC/BBB-BQB/1693/2014
Post-doc Fellow
Instituto de Medicina Molecular João Lobo Antunes, Portugal
|
Fundação ABC Fundação para a Ciência e a Tecnologia Concluded
|
| 2011/05/01 - 2014/01/31 | Does Cholesterol promote angiogenesis and metastasis formation?
PTDC/SAU-ONC/114080/2009
Post-doc Fellow
|
Concluded
|
Outputs
Publications
| Book chapter |
|
| Journal article |
|
| Preprint |
|
| Thesis / Dissertation |
|
Activities
Oral presentation
| Presentation title | Event name Host (Event location) |
|
|---|---|---|
| 2024/07/07 | A positive feedback loop between IFN-y signaling and cholesterol uptake sustains PD-L1 expression in breast cancer cells | Lipids and Cell Plasticity Simposium
Universidade de Aveiro (Aveiro, Portugal)
|
| 2023/05/03 | How cholesterol affects the movement of molecules and cancer cells in and out blood vessels | Seminar
ITQB NOVA (Lisboa, Portugal)
|
| 2022/10 | High cholesterol diet promotes the intravasation of tumor cells through an LDL-LDLR axis | Diet, Nutrition and Cancer Cell Metabolism
Spanish National Cancer Research Center (Madrid, Spain)
|
| 2020/07/25 | High systemic LDL accelerates the intravasation of breast cancer cells through a vascular-mimicry-like mechanism | CANCER BIOLOGY: FROM BASIC TO TRANSLATIONAL RESEARCH
Liga Portuguesa Contra o Cancro, (Lisboa, Portugal)
|
Supervision
| Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
|---|---|---|
| 2023/11/21 - Current | Understanding the cell biology of vascular mimicry using complex in vitro systems
Supervisor
|
Mestrado em Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
| 2021/09/01 - Current | Unravelling Breast Cancer Intravasation: The role of LDL-Cholesterol
Supervisor
|
Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
| 2021/09/01 - 2023/09/29 | How cytokines in breast tumor microenvironment regulate LDLR expression and its implications for tumor progression
Co-supervisor
|
Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
| 2020/01/10 - 2022/02/22 | Regulation of LDLR expression in breast cancer cells and its implication in metastasis
Supervisor
|
Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
|
| 2018/10/18 - 2019/10/30 | Molecular mechanisms that regulate the effect of low density lipoprotein in breast cancer transendothelial migration: the
roles of Her2 and LDLR
Co-supervisor
|
Estudos Básicos de Medicina
Universidade de Lisboa Faculdade de Medicina, Portugal
|
| 2019/01/01 - 2019/06/30 | Regulation of LDLR expression in breast cancer cells
Co-supervisor
|
Bioquímica (Degree)
Universidade de Évora, Portugal
|
| 2014/10/01 - 2015/09/30 | Role for tumor exosomes on angiogenesis and endothelial permeability.
Co-supervisor
|
Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
| 2014/10/01 - 2015/09/30 | Does host LDL receptor contribute to tumor progression?
Co-supervisor
|
Biologia Evolutiva e do Desenvolvimento (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
|
| 2013/10/01 - 2014/07/31 | Contribution of intracellular cholesterol levels to the expression of VEGF-C and VEGFR-3 in Acute Myeloid Leukemia
Co-supervisor
|
Ciências Biomédicas
Universidade do Algarve, Portugal
|
Event participation
| Activity description Type of event |
Event name Institution / Organization |
|
|---|---|---|
| 2023/11 - Current | Poster - A positive feedback loop between IFN-gamma signaling and cholesterol uptake sustains PDL-1 expression in triple
negative breast cancer cells
Congress
|
Metastasis (CNIO-CaixaResearch Frontiers Meeting)
Centro Nacional de Investigaciones Oncológicas, Spain
|
| 2019/09/07 - 2019/09/09 | Presentation of a poster entitled: LDL-cholesterol favors vascular invasion by breast cancer cells.
Congress
|
EACR meeting: Seed and Soil: Mechanisms of Metastasis. Berlin, Germany. |
| 2019/03/02 - 2019/03/04 | Presentation of a poster entitled: High systemic LDL accelerates the intravasation of breast cancer cells through a vascular-mimicry
like mechanism.
Conference
|
EACR-AACR-ASPIC Conference on Tumor Microenvironment |
| 2018/06/10 - 2018/06/14 | Poster presentation entitled: Low density lipoprotein favors the entry of tumor cells in circulation. | Internacional Cancer Microenvironment Society Congress. Lisboa, Portugal |
Jury of academic degree
| Topic Role |
Candidate name (Type of degree) Institution / Organization |
|
|---|---|---|
| 2024/08/30 | The role of Rab6A-mediated protein trafficking in vascular development.
(Thesis) Main arguer
|
Marta Fernandes Pimentel Saraiva (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
| 2024/02/20 | Targeting hepatocellular carcinoma with malaria parasites
(Thesis) Main arguer
|
Laura-Isabell Jantz (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
|
| 2021/11/26 | Studying cancer cell migration under confinement and with correlative microscopy
(Thesis) Main arguer
|
Joana Marques Pinto Monteiro (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
|
| 2020/12/11 | Re-purposing Delta One T cells for immunotherapy of solid tumours: Colon cancer as proof-of-principle
Thesis Member
|
Pedro Batalha (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
|
| 2020/07/23 | Friend or Foe - Apoptosis-Induced Proliferation: Implications for Regeneration and Cancer.
Thesis Member
|
Lourenço Teles de Freitas Saldanha (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
| 2019/12/09 | Low Doses if Ionizing Radiation Induce Angiogenesis: Therapeutic Implications.
Thesis Member
|
Filipa Gil Marques (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
|
| 2018/10/29 | Immune Response in Breast Cancer
(Thesis) Main arguer
|
Tiago Roberto Gomes Pestana (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
|
| 2016 | Study of cell penetrating peptides as drug delivery systems for chemotherapeutic drugs and their properties
(Thesis) Main arguer
|
Filipa Dias de Oliveira (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
|
| 2015 | Fighting breast cancer using membrane-active peptides
(Thesis) Main arguer
|
Inês Filipa de Oliveira Almeida (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
|
Committee member
| Activity description Role |
Institution / Organization | |
|---|---|---|
| 2024/02/01 - Current | Member of the PhD thesis committee of Francisca Xara-Brasil with a thesis focusing on Alternative transcript expression in
colorectal cancer:from (dys)regulation to prognosis and therapeutics- AM participates in the jury as an expert on cancer biology
(wet lab). The committee gets together with the candidate once every year and evaluates project progression giving advices
to the candidate at the end of each meeting for the smooth progression of the project.
Member
|
Instituto de Medicina Molecular João Lobo Antunes, Portugal |
| 2022/09/01 - Current | Member of the PhD thesis committee of Daniela Ramalho with a thesis focusing on Mechanisms of Cell Migration in Arteriogenesis.
AM participates in the jury as an expert on endothelial cell biology and in vitro modeling of vascular functions. The committee
gets together with the candidate once every year and evaluates project progression giving advices to the candidate at the
end of each meeting for the smooth progression of the project.
Member
|
Instituto de Medicina Molecular João Lobo Antunes, Portugal |
| 2016/10/01 - Current | Member of Julia Skalska Lisbon Biomed PhD thesis Commitee. Participated in anual Thesis Commitees to evaluate the progression
of the candidate´s studies.
Member
|
Universidade de Lisboa Faculdade de Medicina, Portugal |
Conference scientific committee
| Conference name | Conference host | |
|---|---|---|
| 2023/11/14 - Current | Prémio Rede Saúde ULisboa 2023 | Universidade de Lisboa, Lisboa |
| 2021 - Current | IMED Innovate Competition | Faculdade de Medicina, Universidade Nova de Lisboa |
| 2023/05/09 - 2023/05/12 | XVI CAML PhD Students Meeting | IMM, Lisboa |
| 2022/03/10 - 2022/03/13 | Research Competition, AIMS Meeting | IMM, Lisboa |
Interview (newspaper / magazine)
| Activity description | Newspaper / Forum | |
|---|---|---|
| 2020/10/01 | Entrevista para um artigo a ser publicado em Outubro de 2020, no âmbito mês internacional de luta contra o cancro da mama, sobre o tema do projeto em que sou investigadora responsável e que foi galardoado com o prémio do Fundo iMM-LAÇO. Interview for a publication in October, which is the International Month for the Fight against Breast Cancer. I was interviewed because I was the awardee of the 2019 prize FUNDO iMM-LAÇO, that each year awards a grant for an innovative research project on Breast Cancer. | DN |
Journal scientific committee
| Journal title (ISSN) | Publisher | |
|---|---|---|
| 2017/04/01 - 2017/04/30 | Journal of Cell Science (1477-9137) | The Company of Biologists |