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Miguel Xavier obtained his PhD from the University of Southampton (UoS) in 2018, as one of the 15 fellows recruited by the MSCA ITN LAPASO project (grant agreement no. 607350). The project brought together world-leading experts in microfluidics, lab-on-a-chip, and single cell sorting and analysis from top European academic and industrial institutions. This network created valuable collaborations that remain highly active today. Miguel's PhD was multidisciplinary and focused on the development of new microfluidic tools for label-free enrichment and characterisation of primary human bone marrow stem cells. The work resulted in the publication of 3 original research papers as first author, a review and, in 2017, MX was awarded the Gold Medal for Engineering as a Young Researcher at the STEM for Britain competition. He has also disseminated his research to the general public in science outreach events and in multiple international conferences where he has won awards for best poster and oral presentations. MX remains a Visiting Academic at the UoS under the invitation of Professor Richard Oreffo (H-index 92). In late 2018, MX was invited to join the INL to work on microfluidic applications to Life Sciences. At the INL, he founded the Microfluidics hub community and was appointed as one of the managers of the tissue culture and microfluidics labs. MX has continuously been involved in teaching, first as a demonstrator in practical classes at the UoS and as the supervisor of PhD, MSc and project students at INL. MX has also been able to secure his own funding through national, international and European funding agencies, including being awarded an MSCA Individual Fellowship in 2020 to execute the GASTRIC project (grant agreement no. 101003440). Thus far, Miguel has been involved in securing projects attracting nearly 2M€. His current h-index is 9 from 14 publications (9 as first author and two as last author) and one book chapter. Miguel's professional ambition is to become an independent researcher in the field of microfluidics applied to the life sciences, hoping to drive the development of innovative applications with a direct impact in people's quality of life.
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Identification

Personal identification

Full name
Jorge Miguel Queiros de Almeida Xavier

Citation names

  • Xavier, Miguel

Author identifiers

Ciência ID
B01F-7F71-CC98
ORCID iD
0000-0002-0447-5439
Google Scholar ID
https://scholar.google.pt/citations?user=Q72DHa8AAAAJ&hl=en
Researcher Id
I-5862-2015
Scopus Author Id
57189376930

Email addresses

  • miguel.xavier@inl.int (Professional)

Addresses

  • Av Mestre José Veiga, 4715-330, Braga, Braga, Portugal (Professional)

Websites

Knowledge fields

  • Engineering and Technology
  • Engineering and Technology - Medical Engineering
  • Engineering and Technology - Nano-technology
  • Exact Sciences - Physical Sciences
  • Natural sciences - Biological Sciences - Biophysics
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
Spanish; Castilian Elementary (A2) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2014/09/01 - 2018/05/29
Concluded
 Electronics and Electrical Engineering (Doctor of Philosophy)
University of Southampton, United Kingdom
"Label-free, microfluidic characterisation and sorting of human skeletal stem cells" (THESIS/DISSERTATION)
2007/09 - 2012/10/08
Concluded
 Bioengenharia (Mestrado integrado)
Major in Engenharia Biomédica
Universidade do Porto Faculdade de Engenharia, Portugal
"Study and Development of a model for mimicking the gastric mucosa" (THESIS/DISSERTATION)
 16/20
2004/09 - 2007/07
Concluded
 Ciências e Tecnologias (Ensino secundário)
Escola Secundária Martins Sarmento, Portugal
 188/200
Affiliation

Science

Category
Host institution 		Employer
2018/10/16 - Current Contracted Researcher (Research) International Iberian Nanotechnology Laboratory, Portugal
2018/08 - Current Visiting Researcher (Research) University of Southampton, United Kingdom
2014/09 - 2018/08 Researcher (Research) University of Southampton, United Kingdom
2013/01/01 - 2014/08/06 Research Assistant (Research) Instituto Nacional de Engenharia Biomédica, Portugal
2014/01 - 2014/02 Visiting Researcher (Research) Universidade da Madeira Centro de Química da Madeira, Portugal
Instituto Nacional de Engenharia Biomédica, Portugal
Projects

Grant

Designation Funders
2023/01 - 2027/12 3DSecret - 3D spheroids derived from single cells for discovering stochastic patterns behind metastasis
101099066
Co-Principal Investigator (Co-PI)
European Commission
Ongoing
2022/01 - 2024/12 JumpIN - HiJacking the peripheral neurons retrograde trafficking machinery to deliver neUroprotective Molecules to sPinal cord InterNeurons
PTDC-BTM-MAT4156.2021
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2020/10 - 2022/10 Gastrointestinal Tract on Chip - An automated microfluidics-based modular device for complete simulation of the processes of digestion and absorption of orally ingested bioactive compounds
101003440
 European Commission
2018/10/16 - 2021/04/30 Modular micro-device for human gastrointestinal tract simulation: MICRODIGEST
037716
Research Fellow
International Iberian Nanotechnology Laboratory, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2013/01/01 - 2014/08 DENDRIMAT - New materials for drug/gene delivery based on the self-assembly of dendrimer-chitosan-single stranded DNA
info:eu-repo/grantAgreement/FCT/3599-PPCDT/112428/PT
Researcher
Instituto Nacional de Engenharia Biomédica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018/02 - 2018/08 Development of a Microfluidic Lab-On-a-Chip Device into a Working Prototype for Clinical Application in Bone Tissue Engineering
HEIF
Post-doc Fellow
University of Southampton, United Kingdom
 Higher Education Funding Council for England
Concluded
2017/10 - 2018/08 Identifying the skeletal stem cell for regeneration: harnessing smart nanoparticles and single cell DropSeq molecular profiling platforms
BB/P017711/1
Post-doc Fellow
University of Southampton Institute of Developmental Science, United Kingdom
 Biotechnology and Biological Sciences Research Council
Ongoing
2014/09/01 - 2017/08/31 LAPASO - Microfluidics for label-free particle sorting
607350
PhD Student Fellow
University of Southampton, United Kingdom
 European Commission
Concluded
Outputs

Publications

Book chapter
  1. Alexandra Teixeira; Adriana Carneiro; Paulina Piairo; Xavier, Miguel; Alar Ainla; Cláudia Lopes; Maria Sousa-Silva; et al. "Advances in Microfluidics for the Implementation of Liquid Biopsy in Clinical Routine". 2022.
    10.1007/978-3-031-04039-9_22
Conference paper
  1. Xavier, Miguel; Spencer, D.; Oreffo, R.O.C.; Morgan, H.. "Label-free Microfluidic sorting of primary human Skeletal stem cells for bone regeneration: A bio-physical characterisation". 2016.
Conference poster
  1. Spencer, Ana; Xavier, Miguel; Guimarães, Sofia Cunha; Leiro, Victoria; Pêgo, Ana Paula. "Exploring Microfluidics as a Neuro-platform Towards the Design of a Novel Targeted Dendritic Vectors". Paper presented in 32nd Annual Conference of the European Society for Biomaterials (ESB), 2022.
  2. Spencer, Ana; Xavier, Miguel; Guimarães, Sofia Cunha; Victoria Leiro; Pêgo, Ana. "Exploring Microfluidics as a Neuro-platform Towards the Design of a Novel Targeted Dendritic Vector". Paper presented in 32nd Annual Conference of the European Society for Biomaterials (ESB), 2022.
  3. Spencer, Ana; Xavier, Miguel; Guimaraes, S.C; Leiro, Victoria; Pêgo, Ana Paula. Corresponding author: Pêgo, Ana Paula. "Microfluidics for the assessment of nanoparticle intracellular trafficking in neurons". Paper presented in FENS Forum 2022 | International Neuroscience Conference. Paris, France, 2022.
  4. Santos, SD; Xavier, Miguel; Leite DM; Moreira, Débora; Custódio, Beatriz; Torrado M; Castro, R.; et al. "The transport of therapeutic molecules to the ischemic brain: dendrimers as carriers in pre-clinical studies". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  5. Santos, SD; Xavier, Miguel; Leite, DM; Moreira, Débora; Custódio, Beatriz; Torrado M; Castro, R; et al. "Blood-Brain Barrier Transport and Neuronal Uptake of PAMAM Dendrimers after Focal Brain Ischemia". Paper presented in i3S annual meeting, 2018.
  6. Santos, SD; Xavier, Miguel; Leite DM; Moreira, Débora; Castro, R; Leiro, Victoria; Rodrigues, J.; Tomás, Helena; Pêgo, Ana. "Nanoparticle-mediated Blood-Brain Barrier Transport for Neuronal Delivery in Focal Brain Ischemia". Paper presented in 10th International Symposium on Neuroprotection and Neurorepair, 2018.
Journal article
  1. Spencer, Ana; Xavier, Miguel; Guimarães, Ana Sofia; adriana vilaça; Ariel Ionescu; Rafael Santos; Gomez-Lazaro, Maria; et al. "Unveiling the potential of neuron-targeted dendriplexes for siRNA with a PNS-CNS-on-chip model". Nano Today (2024):
    Submitted
  2. Spencer, Ana; Adriana Vilaça; Guimarães, Ana Sofia; Xavier, Miguel; Rafael Santos; Ariel Ionescu; Gomez-Lazaro, Maria; et al. "Advancing neurotherapeutics: chitosan nanoparticles as efficient vehicles for siRNA delivery". Small (2024):
    Submitted
  3. Maria Helena Macedo; Mafalda Dias Neto; Lorenzo Pastrana; Catarina Gonçalves; Xavier, Miguel. Corresponding author: Xavier, Miguel. "Recent Advances in Cell-Based In Vitro Models to Recreate Human Intestinal Inflammation". Advanced Science (2023): http://dx.doi.org/10.1002/advs.202301391.
    10.1002/advs.202301391
  4. Xavier, Miguel; Patrícia M. Rodrigues; Mafalda Dias Neto; Maria I. Guedes; Victor Calero; Lorenzo Pastrana; Catarina Gonçalves. "From mouth to gut: microfluidic in vitro simulation of human gastro-intestinal digestion and intestinal permeability". The Analyst (2023): http://dx.doi.org/10.1039/d2an02088b.
    10.1039/d2an02088b
  5. Inês A. Parente; Xavier, Miguel; Dalila Roupar; Isabel R. Amado; Paulo Berni; Cláudia Botelho; José A. Teixeira; et al. "Effect of prebiotic fermentation products from primary human gut microbiota on an in vitro intestinal model". Journal of Functional Foods (2022): http://dx.doi.org/10.1016/j.jff.2022.105200.
    10.1016/j.jff.2022.105200
  6. Patrícia M. Rodrigues; Xavier, Miguel; Victor Calero; Lorenzo Pastrana; Catarina Gonçalves. "Partitioning of Small Hydrophobic Molecules into Polydimethylsiloxane in Microfluidic Analytical Devices". Micromachines (2022): https://www.mdpi.com/2072-666X/13/5/713.
    10.3390/mi13050713
  7. Xavier, Miguel; Parente, Inês A.; Rodrigues, Patrícia M.; Cerqueira, Miguel A.; Pastrana, Lorenzo; Gonçalves, Catarina. "Safety and fate of nanomaterials in food: The role of in vitro tests". Trends in Food Science & Technology 109 (2021): 593-607. http://dx.doi.org/10.1016/j.tifs.2021.01.050.
    10.1016/j.tifs.2021.01.050
  8. Xavier, Miguel; Kyriazi, Maria-Eleni; Lanham, Stuart; Alexaki, Konstantina; Matthews, Elloise; El-Sagheer, Afaf H.; Brown, Tom; Kanaras, Antonios G.; Oreffo, Richard O. C.. "Enrichment of Skeletal Stem Cells from Human Bone Marrow Using Spherical Nucleic Acids". ACS Nano (2021): https://publons.com/wos-op/publon/43672242/.
    10.1021/ACSNANO.0C10683
  9. Costa JR; Xavier, Miguel; Amado IR; Gonçalves C; Castro PM; Tonon RV; Cabral LMC; Pastrana L; Pintado ME. "Polymeric nanoparticles as oral delivery systems for a grape pomace extract towards the improvement of biological activities.". Materials science & engineering. C, Materials for biological applications (2020): http://europepmc.org/abstract/med/33321615.
    10.1016/j.msec.2020.111551
  10. Xavier, Miguel; García-Hevia, Lorena; Amado, Isabel R; Pastrana, Lorenzo; Gonçalves, Catarina. "<p>In Vitro Intestinal Uptake And Permeability Of Fluorescently-Labelled Hyaluronic Acid Nanogels</p>". International Journal of Nanomedicine Volume 14 (2019): 9077-9088. http://dx.doi.org/10.2147/ijn.s224255.
    10.2147/ijn.s224255
  11. Xavier, Miguel; Holm SH; Beech JP; Spencer D; Tegenfeldt JO; Oreffo ROC; Morgan H. "Label-free enrichment of primary human skeletal progenitor cells using deterministic lateral displacement.". Lab on a chip (2019): http://europepmc.org/abstract/med/30632599.
    10.1039/c8lc01154k
  12. Sofia D. Santos; Xavier, Miguel; Diana M. Leite; Débora A. Moreira; Beatriz Custódio; Marília Torrado; Rita Castro; et al. "PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia". Journal of Controlled Release (2018): https://doi.org/10.1016%2Fj.jconrel.2018.10.006.
    10.1016/j.jconrel.2018.10.006
  13. Xavier, Miguel; María C. de Andrés; Daniel Spencer; Richard O. C. Oreffo; Hywel Morgan. "Size and dielectric properties of skeletal stem cells change critically after enrichment and expansion from human bone marrow: consequences for microfluidic cell sorting". Journal of The Royal Society Interface 14 133 (2017): 20170233-20170233. https://doi.org/10.1098%2Frsif.2017.0233.
    10.1098/rsif.2017.0233
  14. Xavier, Miguel; Oreffo, R.O.C.; Morgan, H.. "Skeletal stem cell isolation: A review on the state-of-the-art microfluidic label-free sorting techniques". Biotechnology Advances 34 5 (2016): 908-923. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973900767&partnerID=MN8TOARS.
    10.1016/j.biotechadv.2016.05.008
  15. Xavier, Miguel; Rosendahl, P.; Herbig, M.; Kräter, M.; Spencer, D.; Bornhäuser, M.; Oreffo, R.O.C.; et al. "Mechanical phenotyping of primary human skeletal stem cells in heterogeneous populations by real-time deformability cytometry". Integrative Biology (United Kingdom) 8 5 (2016): 616-623. http://www.scopus.com/inward/record.url?eid=2-s2.0-84969929926&partnerID=MN8TOARS.
    10.1039/c5ib00304k

Other

Other output
  1. Optimising DNA-Coated Gold Nanoparticles to Enrich Skeletal Stem Cells from Human Bone Marrow Samples. 2019. Xavier, Miguel. http://dx.doi.org/10.1101/2019.12.19.882563.
    10.1101/2019.12.19.882563
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02/06 Dos and Don’ts of microfluidics and organ-on-a-chip devices XIX Jornadas de Engenharia Biomédica
(Portugal)
2022/06 Microfluidics for Complete Simulation of the Human Gastrointestinal Tract. EMBL Microfluidics 2022
(Heidelberg, Germany)
2021/11 Microfluidic Simulation of Human Gastrointestinal Digestion and Cell-based Intestinal Absorption. Nanobiotech Montreux Nanobiotech Montreux
(Montreux, Switzerland)
2021/06/29 Microfluidics for Biomedical Engineering Applications: From Cell Sorting to Organ-On-Chip 4th Doctoral College in Engineering
(Portugal)
2019/02 Microfluidics, from cell sorting to organ-on-a-chip IV Jornadas de Bioengenharia UTAD
(Portugal)
2017/09 Size and deformation-based cell sorting using deterministic lateral displacement – prospects for skeletal stem cell isolation from bone marrow European workshop on label-free particle sorting
(Lund, Sweden)
2017/06 Microfluidic characterisation of size, dielectric and mechanical properties of primary skeletal stem cells from human bone marrow for label-free cell isolation Gordon Research Seminar – Physics and Chemistry of Microfluidics
(Lucca, Italy)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/02 - Current Development of a bioengineered patient-specific microphysiological in vitro model of intestinal inflammation
Co-supervisor
2023/01 - 2024/02 Assessment of the viability of circulating tumor cells in microfluidics
Supervisor
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências e Tecnologia, Portugal
2023/01 - 2024/01 Short-chain fatty acids as potential modulators of a new ruthenium-based anticancer drug in colorectal cancer therapy
Supervisor
Universidade do Minho Escola de Ciências, Portugal
2019/07 - 2022/11 Modification of polydimethylsiloxane (PDMS) to reduce the absorption of small molecules in analytical microfluidic devices
Co-supervisor
 Biofísica e Bionanossistemas (Master)
Universidade do Minho Escola de Ciências, Portugal
2022/01 - 2022/09 Development of functional gut-on-chip epithelial models to study intestinal absorption
Supervisor
Universidade do Porto Faculdade de Engenharia, Portugal
2021/05 - 2022/02 CELL-BASED MICRODEVICE AS A TOOL FOR PREDICTIVE INTESTINAL RESPONSES
Co-supervisor
 Engenharia Biomédica (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/03 - 2022/02 Development of a sensorised and automated digestion-on-chip device
Supervisor
2019/09 - 2021/01 Development of a new Colon-Host simulator
Co-supervisor
 Mestrado em Biotecnologia (Master)
Universidade do Minho Escola de Engenharia, Portugal
2019/07 - 2020/02 Development of low-cost peripherals for the operation of microfluidic devices
Supervisor of Ricardo Nuno Marquês Cardoso
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/06 - Current Chair of the GRS Physics and Chemistry of Microfluidics 2025 (2023/06)
Conference (Member of the Organising Committee)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/02/26 Development of a microfluidic-based 3D bioprinting systems to create hierarchical in vitro models of human tissues
(Thesis) Arguer
 Federico Serpe (PhD)
Università degli Studi di Roma La Sapienza, Italy
2023 Cancer models in Organ-on-a-Chip systems
(Thesis) Main arguer
 JOÃO PEDRO SANTANA CERDEIRA (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 ESTABLISHMENT OF A 3D MULTI-LAYERED INTESTINAL INFLAMMATION MODEL
(Thesis) Main arguer
 Bárbara Ferreira (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/06 Mimicking the bone in a 3D compartmentalized microfluidic chip to fight cancer associated bone pain
(Thesis) Arguer
 Andrea Bortolin (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
2018/10 Development of bacteriophage-loaded microstructures using Microfluidics
(Thesis) Main arguer
 Luís Filipe Alves Passos (Master)
Universidade do Minho Escola de Engenharia, Portugal

Conference scientific committee

Conference name Conference host
2021 - 2022 European Society of Biomaterials
2021 - 2021 Nanobiotech Montreux

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023 - 2034 Micro and nano technologies for cancer research (Curso de mestrado (conclusão do curso de especialização)) Universidade do Minho, Portugal
2014/11 - 2017/11 Lab tutorials on microfabrication and microcontact printing Bionanotechnology (Bachelor) University of Southampton Faculty of Physical Sciences and Engineering, United Kingdom

Journal scientific committee

Journal title (ISSN) Publisher
2021/01 - 2022/06 Micromachines (2072-666X) MDPI

Mentoring / Tutoring

Topic Student name
2019/04 - 2019/09 On-chip culture of human endothelial and cancer cells Elisa Hysaj
Distinctions

Award

2021 Best Scientific Demo
European Researcher's Night organising committee, Portugal
2017 Gold Medal for Excellence in Engineering by a Young Research
The Houses of Parliament, United Kingdom
2017 Winner of the 3-Minute Thesis Faculty Competition
University of Southampton Faculty of Physical Sciences and Engineering, United Kingdom
2017 Best oral communication
European Workshop on Label-free Particle Sorting, Sweden
2017 Best oral communication
University of Southampton, United Kingdom
2013 Best Poster communication
Instituto Nacional de Engenharia Biomédica, Portugal
2007 Best Sciences Student Award
Associação dos Antigos Estudantes do Liceu de Guimarães, Portugal
2007 Best Mathematics Student Award
Associação dos Antigos Estudantes do Liceu de Guimarães, Portugal
2007 Merit and Excellence Award
Escola Secundária Martins Sarmento, Portugal