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Maria Jose Schuller Almeida. Concluiu o(a) Doutoramento em n/a em 1997 pelo(a) Universidade do Porto. Publicou 20 artigos em revistas especializadas. Atua na(s) área(s) de Ciências Naturais com ênfase em Ciências da Terra e do Ambiente com ênfase em Recursos Aquáticos.
Identification

Personal identification

Full name
Maria Jose Schuller Almeida

Citation names

  • Almeida, Maria

Author identifiers

Ciência ID
B11F-C8BD-231F
ORCID iD
0000-0002-6722-9200

Knowledge fields

  • Natural sciences - Earth and Environmental Sciences - Water Resources

Languages

Language Speaking Reading Writing Listening Peer-review
French Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
1997
Concluded
 n/a (Doutoramento)
Universidade do Porto, Portugal
"Crescimento em ostras: factores que afectam a formacao e estrutura da concha" (THESIS/DISSERTATION)
 n/a
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2018/07/01 - Current Full Professor (University Teacher) University of Arkansas for Medical Sciences College of Medicine, United States
University of Arkansas for Medical Sciences College of Medicine, United States

Others

Category
Host institution 		Employer
2005/06/01 - 2011/05/31 Assistant Professor (tenure track) University of Arkansas for Medical Sciences College of Medicine, United States
2002/02/18 - 2005/05/31 Post-Doctoral Fellow University of Arkansas for Medical Sciences, United States
2000/10/01 - 2002/01/31 Post-Doctoral Fellow Instituto Nacional de Engenharia Biomédica, Portugal
1997/09/01 - 1999/10/31 Post-Doctoral Fellow Centre National de la Recherche Scientifique, France
Outputs

Publications

Journal article
  1. Almeida, Maria. "Cxcl12 deletion in mesenchymal cells increases bone turnover and attenuates the loss of cortical bone caused by estrogen deficiency in mice.". Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (2020): https://doi.org/10.1002/jbmr.4002.
    10.1002/jbmr.4002
  2. Almeida, Maria. "Stimulation of Piezo1 by mechanical signals promotes bone anabolism.". eLife (2019): https://europepmc.org/articles/PMC6779475.
    10.7554/eLife.49631
  3. Almeida, Maria. "Elimination of senescent osteoclast progenitors has no effect on the age-associated loss of bone mass in mice.". Aging cell (2019): https://europepmc.org/articles/PMC6516158.
    10.1111/acel.12923
  4. Almeida, Maria. "Sirtuins and FoxOs in osteoporosis and osteoarthritis.". Bone (2019): https://doi.org/10.1016/j.bone.2019.01.018.
    10.1016/j.bone.2019.01.018
  5. Almeida, Maria. "The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal Aging.". Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (2018): https://europepmc.org/articles/PMC6327947.
    10.1002/jbmr.3564
  6. Almeida, Maria. "The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation.". Bone (2018): https://europepmc.org/articles/PMC5970058.
    10.1016/j.bone.2018.04.001
  7. Almeida, Maria. "The Role of FoxOs in Bone Health and Disease.". Current topics in developmental biology (2017): https://doi.org/10.1016/bs.ctdb.2017.10.004.
    10.1016/bs.ctdb.2017.10.004
  8. Marilina Piemontese; Maria Almeida; Alexander G. Robling; Ha-Neui Kim; Jinhu Xiong; Jeff D. Thostenson; Robert S. Weinstein; et al. "Old age causes de novo intracortical bone remodeling and porosity in mice". JCI Insight 2 17 (2017): https://doi.org/10.1172%2Fjci.insight.93771.
    10.1172/jci.insight.93771
  9. Almeida, Maria. "DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age.". Aging cell (2017): https://europepmc.org/articles/PMC5506444.
    10.1111/acel.12597
  10. Almeida, Maria. "Estrogens and Androgens in Skeletal Physiology and Pathophysiology.". Physiological reviews (2017): https://europepmc.org/articles/PMC5539371.
    10.1152/physrev.00033.2015
  11. Almeida, Maria. "The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct.". Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (2016): https://europepmc.org/articles/PMC5340621.
    10.1002/jbmr.3014
  12. Almeida, Maria. "CathepsinKCre mediated deletion of ßcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells.". Scientific reports (2016): https://europepmc.org/articles/PMC5090355.
    10.1038/srep36201
  13. Almeida, Maria. "Deletion of FoxO1, 3, and 4 in Osteoblast Progenitors Attenuates the Loss of Cancellous Bone Mass in a Mouse Model of Type 1 Diabetes.". Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (2016): https://europepmc.org/articles/PMC5492385.
    10.1002/jbmr.2934
  14. Almeida, Maria. "Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage.". Scientific reports (2016): https://europepmc.org/articles/PMC4827128.
    10.1038/srep24262
  15. Almeida, Maria. "Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice.". American journal of physiology. Endocrinology and metabolism (2016): https://europepmc.org/articles/PMC6415649.
    10.1152/ajpendo.00501.2015
  16. Almeida, Maria. "Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs.". Molecular endocrinology (Baltimore, Md.) (2015): https://europepmc.org/articles/PMC4588729.
    10.1210/me.2015-1133
  17. Almeida, Maria. "The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERa Signaling in Osteoblasts and Osteoclasts.". Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (2015): https://europepmc.org/articles/PMC4871247.
    10.1002/jbmr.2485
  18. Almeida, Maria. "Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone.". Bone (2015): https://europepmc.org/articles/PMC4387016.
    10.1016/j.bone.2015.02.005
  19. Almeida, Maria. "Sirtuin1 (Sirt1) promotes cortical bone formation by preventing ß-catenin sequestration by FoxO transcription factors in osteoblast progenitors.". The Journal of biological chemistry (2014): https://europepmc.org/articles/PMC4148840.
    10.1074/jbc.M114.561803
  20. Almeida, Maria. "SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.". Aging cell (2014): https://europepmc.org/articles/PMC4172519.
    10.1111/acel.12220
  21. Almeida, Maria. "FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation.". Nature communications (2014): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24781012/?tool=EBI.
    10.1038/ncomms4773
  22. Almeida, Maria. "The role of estrogen and androgen receptors in bone health and disease.". Nature reviews. Endocrinology (2013): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24042328/?tool=EBI.
    10.1038/nrendo.2013.179
  23. Almeida, Maria. "FOXOs attenuate bone formation by suppressing Wnt signaling.". The Journal of clinical investigation (2013): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23867625/?tool=EBI.
    10.1172/JCI68049
  24. Almeida, Maria. "Basic biology of skeletal aging: role of stress response pathways.". The journals of gerontology. Series A, Biological sciences and medical sciences (2013): https://europepmc.org/articles/PMC3779633.
    10.1093/gerona/glt079
  25. Almeida, Maria. "Suppression of autophagy in osteocytes mimics skeletal aging.". The Journal of biological chemistry (2013): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23645674/?tool=EBI.
    10.1074/jbc.M112.444190
  26. Almeida, Maria. "Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass.". Molecular endocrinology (Baltimore, Md.) (2013): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23443267/?tool=EBI.
    10.1210/me.2012-1368
  27. Almeida, Maria. "Estrogen receptor-a signaling in osteoblast progenitors stimulates cortical bone accrual.". The Journal of clinical investigation (2012): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23221342/?tool=EBI.
    10.1172/JCI65910
  28. Almeida, Maria. "Receptor activator of nuclear factor ¿B ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss.". The Journal of biological chemistry (2012): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22782898/?tool=EBI.
    10.1074/jbc.M112.377945
  29. Almeida, Maria. "Aging mechanisms in bone.". BoneKEy reports (2012): https://europepmc.org/articles/PMC3659822.
    10.1038/bonekey.2012.102
  30. Almeida, Maria. "Glucocorticoids and tumor necrosis factor a increase oxidative stress and suppress Wnt protein signaling in osteoblasts.". The Journal of biological chemistry (2011): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22030390/?tool=EBI.
    10.1074/jbc.M111.283481
  31. Almeida, Maria. "Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice.". Endocrinology (2011): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21771887/?tool=EBI.
    10.1210/en.2011-0170
  32. Almeida, Maria. "Unraveling the role of FoxOs in bone--insights from mouse models.". Bone (2011): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21664311/?tool=EBI.
    10.1016/j.bone.2011.05.023
  33. Almeida, Maria. "Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration.". Aging cell (2010): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20698835/?tool=EBI.
    10.1111/j.1474-9726.2010.00616.x
  34. Almeida, Maria. "Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens.". Molecular endocrinology (Baltimore, Md.) (2010): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20685851/?tool=EBI.
    10.1210/me.2010-0189
  35. Almeida, Maria. "Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice.". Endocrinology (2010): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20410195/?tool=EBI.
    10.1210/en.2009-1488
  36. Almeida, Maria. "Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha.". Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (2010): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19821774/?tool=EBI.
    10.1359/jbmr.091017
  37. Almeida, Maria. "FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.". Cell metabolism (2010): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20142101/?tool=EBI.
    10.1016/j.cmet.2009.12.009
  38. Almeida, Maria. "The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone.". Molecular endocrinology (Baltimore, Md.) (2010): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20053716/?tool=EBI.
    10.1210/me.2009-0354
  39. Almeida, Maria. "Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice.". Aging cell (2009): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20047574/?tool=EBI.
    10.1111/j.1474-9726.2009.00545.x
  40. Almeida, Maria. "Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton.". The Journal of biological chemistry (2009): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19657144/?tool=EBI.
    10.1074/jbc.M109.023572
  41. Almeida, Maria. "Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids.". The Journal of biological chemistry (2007): https://europepmc.org/articles/PMC3119455.
    10.1074/jbc.M702810200
  42. Almeida, Maria. "Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription.". The Journal of biological chemistry (2007): https://doi.org/10.1074/jbc.M702811200.
    10.1074/jbc.m702811200
  43. Almeida, Maria. "Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism.". Molecular endocrinology (Baltimore, Md.) (2007): https://doi.org/10.1210/me.2007-0259.
    10.1210/me.2007-0259
  44. Almeida, Maria. "Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor.". Molecular and cellular biology (2006): https://europepmc.org/articles/PMC1800724.
    10.1128/MCB.01550-06
  45. Almeida, Maria. "Classical genotropic versus kinase-initiated regulation of gene transcription by the estrogen receptor alpha.". Endocrinology (2005): https://doi.org/10.1210/en.2005-1314.
    10.1210/en.2005-1314
  46. Almeida, Maria. "Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.". The Journal of biological chemistry (2005): https://doi.org/10.1074/jbc.M502168200.
    10.1074/jbc.m502168200
  47. Almeida, Maria. "Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases.". The Journal of biological chemistry (2005): https://doi.org/10.1074/jbc.M410720200.
    10.1074/jbc.m410720200
  48. Almeida, Maria. "Kinase-mediated transcription, activators of nongenotropic estrogen-like signaling (ANGELS), and osteoporosis: a different perspective on the HRT dilemma.". Kidney international. Supplement (2004): https://doi.org/10.1111/j.1523-1755.2004.09107.x.
    10.1111/j.1523-1755.2004.09107.x
  49. Almeida, Maria. "Regulatory role of endothelium in the expression of genes affecting arterial calcification.". Biochemical and biophysical research communications (2004): https://doi.org/10.1016/j.bbrc.2004.05.181.
    10.1016/j.bbrc.2004.05.181
  50. Almeida, Maria. "Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids.". The Journal of clinical investigation (2003): https://europepmc.org/articles/PMC156107.
    10.1172/JCI200317261
  51. Almeida, Maria. "The water-soluble matrix fraction from the nacre of Pinctada maxima produces earlier mineralization of MC3T3-E1 mouse pre-osteoblasts.". Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology (2003):
  52. Almeida, Maria. "Soluble silk-like organic matrix in the nacreous layer of the bivalve Pinctada maxima.". European journal of biochemistry (2002): https://doi.org/10.1046/j.1432-1033.2002.03203.x.
    10.1046/j.1432-1033.2002.03203.x
  53. Almeida, Maria. "Bioactivity of nacre water-soluble organic matrix from the bivalve mollusk Pinctada maxima in three mammalian cell types: fibroblasts, bone marrow stromal cells and osteoblasts.". Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology (2002): https://doi.org/10.1016/s1096-4959(01)00524-3.
    10.1016/s1096-4959(01)00524-3
  54. Almeida, Maria. "Comparative effects of nacre water-soluble matrix and dexamethasone on the alkaline phosphatase activity of MRC-5 fibroblasts.". Journal of biomedical materials research (2001): https://doi.org/10.1002/1097-4636(200111)57:2<306::aid-jbm1172>3.0.co;2-h.
    10.1002/1097-4636(200111)57:2<306::aid-jbm1172>3.0.co;2-h
  55. Almeida, Maria. "Characterization and quantification of chitosan extracted from nacre of the abalone Haliotis tuberculata and the oyster Pinctada maxima.". Marine biotechnology (New York, N.Y.) (2001): https://doi.org/10.1007/s101260000042.
    10.1007/s101260000042
  56. Almeida, Maria. "Effect of water-soluble matrix fraction extracted from the nacre of Pinctada maxima on the alkaline phosphatase activity of cultured fibroblasts.". The Journal of experimental zoology (2000): https://doi.org/10.1002/1097-010X(20001215)288:4<327::AID-JEZ5>3.0.CO;2-#.
    10.1002/1097-010x(20001215)288:4<327::aid-jez5>3.3.co;2-r
  57. Almeida, Maria. "Stimulation of bone marrow cells and bone formation by nacre: in vivo and in vitro studies.". Bone (1999): https://doi.org/10.1016/s8756-3282(99)00141-6.
    10.1016/s8756-3282(99)00141-6