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Identification

Personal identification

Full name
José Francisco da Silva Cascalheira

Citation names

  • Cascalheira, José

Author identifiers

Ciência ID
B219-078D-FD06
ORCID iD
0000-0002-5315-3866

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Intermediate (B1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2003/05
Concluded
 Biomedicina (Doutoramento)
Major in Sem especialidade
Universidade da Beira Interior, Portugal
"Contribuição para o Estudo da Acção do Receptor A1 da Adenosina no Ciclo do Fosfatidilinositol no Sistema Nervoso Central" (THESIS/DISSERTATION)
 Aprovado (Escala Aprovado/Recusado)
1998
Concluded
 Provas de Aptidão Pedagógica e Capacidade Científica (Outros)
Universidade da Beira Interior, Portugal
"Prova de Capacidade Científica: Aspectos Cinéticos de Enzimas Celulolíticas do Trichoderma reesei; Prova de Aptidão Pedagógica: Determinação dos Parâmetros Cinéticos da beta-glucosidase" (THESIS/DISSERTATION)
 Muito Bom
1990
Concluded
 Licenciatura em Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Caracterização dos Enzimas Intervenientes no Metabolismo Extracelular dos Nucleótidos de Adenina, no Músculo Sartório Inervado de Rã, através da Utilização de Análogos do Substrato" (THESIS/DISSERTATION)
 17 valores
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2003/05 - Current Assistant Professor (University Teacher) Universidade da Beira Interior, Portugal
1998/07 - 2003/05 Assistant (University Teacher) Universidade da Beira Interior, Portugal
1994/11 - 1998/07 Trainee Assistant (University Teacher) Universidade da Beira Interior, Portugal

Others

Category
Host institution 		Employer
1991/04 - 1994/04 graduated student Instituto Gulbenkian de Ciência, Portugal
Projects

Grant

Designation Funders
2022/06/01 - 2023/06/01 Investigation on the role of the glucosensing receptor T1R3 in glioblastoma hallmarks (STARvE)
NA
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Liga Portuguesa Contra o Cancro Núcleo Regional do Centro
Concluded

Contract

Designation Funders
2019/01/01 - 2019/12/31 Health Sciences Research Centre
UID/Multi/00709/2019
Universidade da Beira Interior, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/04/01 - 2019/10/01 Relationship between adenosine and chromosomal instability: a new perspective to understand the oncogenic mechanism in glioblastoma
POCI-01-0145-FEDER-016822
PTDC/BIM-ONC/7121/2014
Principal investigator
Universidade da Beira Interior Faculdade de Ciências, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/01 - 2019/01 Relationship between adenosine and chromosomal instability: a new perspective to understand the oncogenic mechanism in glioblastoma
Provided by PTCRIS: 145766
Principal investigator
Universidade de Coimbra
2011/01/01 - 2013/12/31 Strategic Project - UI 709 - 2011-2012
PEst-C/SAU/UI0709/2011
Universidade da Beira Interior, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/01 - 2009/08 Interplay between endocannabinoids and adenosine in the hipocampus
Provided by PTCRIS: 82399
Researcher
Universidade de Coimbra
2005/08 - 2007/06 Interplay between endocannabinoids and adenosine in the hipocampus
Provided by PTCRIS: 57973
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Outputs

Publications

Conference poster
  1. Cascalheira, José. "Combined antiproliferative effects of metformin and adenosine in glioblastoma". Paper presented in XVI Annual CICS-UBI Symposium, 2021.
  2. Cascalheira, José. "Could bitter taste signaling be an alternative pathway to tackle chemoresistance in glioblastoma?". Paper presented in FENS 2020 Virtual Forum, 2020.
  3. Cascalheira, José. "Effect of increased adenosine levels on cell proliferation: differences between glioblastoma cells and human astrocytes". Paper presented in Webinar on Cancer Biology: From Basic to Translational Research, 2020.
  4. Cascalheira, José. "The anti-tumoral effect of cannabinoids on glioblastoma is modulated by adenosine". Paper presented in Webinar on Cancer Biology: From Basic to Translational Research, 2020.
  5. Cascalheira, José. "The effects of cannabinoids on glioblastoma: results from a meta-analysis of animal models studies". Paper presented in Webinar on Cancer Biology: From Basic to Translational Research, 2020.
  6. Cascalheira, José. "Bitter taste signalling in glioblastoma: an alternative pathway to tackle chemoresistance?". Paper presented in III International Congress in Health Sciences Research – towards innovation and entrepreneurship: Trends in Aging and Cancer, 2019.
  7. Cascalheira, José. "Bitter Taste Signalling in Glioblastoma". Paper presented in FENS Regional Meeting 2019, 2019.
  8. Cascalheira, José. "Bitter Taste Receptors are expressed in glioblastoma cell lines". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  9. Cascalheira, José. "The effects of cannabinoids on glioblastoma growth: results from a meta-analysis of animal model studies". Paper presented in III International Congress in Health Sciences Research – towards innovation and entrepreneurship: Trends in Aging and Cancer, 2019.
  10. Cascalheira, José. "Evaluation of the expression of enzymes involved in adenosine metabolism in Glioblastoma under increased adenosine concentrations". Paper presented in XIV Annual CICS-UBI Symposium, 2019.
  11. Cascalheira, José. "Anti-tumoral effect of canabinnoids on glioblastoma: modulation by adenosine". Paper presented in XIV Annual CICS-UBI Symposium, 2019.
  12. Cascalheira, José. "The role of estradiol in glioblastoma". Paper presented in XIV Annual CICS-UBI Symposium, 2019.
  13. Cascalheira, José. "Role of adenosine on the resistance to an anti-tumor agent in glioblastoma cell lines". Paper presented in XIV Annual CICS-UBI Symposium, 2019.
  14. Cascalheira, José. "Bitter Taste Signalling in Glioblastoma". Paper presented in 11th FENS Forum of Neuroscience, 2018.
  15. Cascalheira, José. "Bitter Taste Signalling in Glioblastoma". Paper presented in XIII CICS-UBI symposium, 2018.
  16. Cascalheira, José. "Astrocyte proliferation is inhibited by adenosine through an intracellular mechanism". Paper presented in Workshop on Integrative Approaches in Neurodegeneration, 2018.
  17. Cascalheira, José. "Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation". Paper presented in 19th biennial meeting for the Society for Free Radical Research International (SFRRI), 2018.
Journal article
  1. Luana M. Rosendo; Mónica Antunes; Ana Y. Simão; Ana Teresa Brinca; Gonçalo Catarro; Rodrigo Pelixo; João Martinho; et al. "Sensors in the Detection of Abused Substances in Forensic Contexts: A Comprehensive Review". Micromachines (2023): http://dx.doi.org/10.3390/mi14122249.
    10.3390/mi14122249
  2. Cascalheira, José; Ângelo Luís; Leonor Amaral; Fernanda Domingues; Luísa Pereira. Corresponding author: Ângelo Luís. "Action of Curcumin on Glioblastoma Growth: A Systematic Review with Meta-Analysis of Animal Model Studies". Biomedicines (2023): https://doi.org/10.3390/biomedicines12020268.
    Open access • Published
  3. Ângelo Luís; Helena Marcelino; Domingues, F.C.; L. Pereira; José Francisco Cascalheira. "Therapeutic Potential of Resveratrol for Glioma: A Systematic Review and Meta-Analysis of Animal Model Studies". International Journal of Molecular Sciences (2023): http://dx.doi.org/10.3390/ijms242316597.
    10.3390/ijms242316597
  4. Cascalheira, José. "Adenosine inhibits cell proliferation differently in human astrocytes and in glioblastoma cell lines". Neuroscience (2021): http://dx.doi.org/10.1016/j.neuroscience.2021.05.019.
    10.1016/j.neuroscience.2021.05.019
  5. Costa, Ana Raquel; Lança de Oliveira, Mariana; Cruz, Inês; Gonçalves, Isabel; Cascalheira, José Francisco; Santos, Cecília R.A.. "The Sex Bias of Cancer". Trends in Endocrinology & Metabolism 31 10 (2020): 785-799. http://dx.doi.org/10.1016/j.tem.2020.07.002.
    10.1016/j.tem.2020.07.002
  6. Luís, Ângelo; Marcelino, Helena; Rosa, Carolina; Domingues, Fernanda; Pereira, Luísa; Cascalheira, José Francisco. "The effects of cannabinoids on glioblastoma growth: A systematic review with meta-analysis of animal model studies". European Journal of Pharmacology 876 (2020): 173055. http://dx.doi.org/10.1016/j.ejphar.2020.173055.
    Published • 10.1016/j.ejphar.2020.173055
  7. Marcelino, Helena; Nogueira, Vanda C.; Santos, Cecília R.A.; Quelhas, Patrícia; Carvalho, Tiago M.A.; Fonseca-Gomes, João; Tomás, Joana; et al. "Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation". Journal of Neurochemistry (2020): http://dx.doi.org/10.1111/jnc.14937.
    10.1111/jnc.14937
  8. Marcelino, Helena; Santos, Cecilia; Nogueira, Vanda; Fonseca-Gomes, João; Tomás, Joana; Diógenes, Maria José; Sebastião, Ana; Cascalheira, José. "The inhibitory effect of adenosine on human astrocyte proliferation is absent in glioblastoma cell lines.". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/conf.fncel.2019.01.00004.
    10.3389/conf.fncel.2019.01.00004
  9. Nogueira, Vanda; Sebastião, Ana; Cascalheira, José; Valente, Claudia. "Role of adenosine on the resistance to an anti-tumor agent in glioblastoma cell lines". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/conf.fncel.2019.01.00009.
    10.3389/conf.fncel.2019.01.00009
  10. Pinto, Isa; Serpa, André; Sebastião, Ana M.; Cascalheira, José F.. "The Role of cGMP on Adenosine A1 Receptor-mediated Inhibition of Synaptic Transmission at the Hippocampus". Frontiers in Pharmacology 7 (2016): http://dx.doi.org/10.3389/fphar.2016.00103.
    10.3389/fphar.2016.00103
  11. Serpa, A.; Correia, S.; Ribeiro, J.A.; Sebastião, A.M.; Cascalheira, J.F.. "The combined inhibitory effect of the adenosine Aand cannabinoid CBReceptors on cAMP accumulation in the hippocampus is additive and independent of Areceptor desensitization". BioMed Research International 2015 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84922389779&partnerID=MN8TOARS.
    10.1155/2015/872684
  12. Henao-Escobar, W.; Domínguez-Renedo, O.; Alonso-Lomillo, M.A.; Cascalheira, J.F.; Dias-Cabral, A.C.; Arcos-Martínez, M.J.. "Characterization of a Disposable Electrochemical Biosensor Based on Putrescine Oxidase from Micrococcus rubens for the Determination of Putrescine". Electroanalysis 27 2 (2015): 368-377. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930940900&partnerID=MN8TOARS.
    10.1002/elan.201400387
  13. Serpa, A.; Pinto, I.; Bernardino, L.; Cascalheira, J.F.. "Combined neuroprotective action of adenosine A1 and cannabinoid CB1 receptors against NMDA-induced excitotoxicity in the hippocampus". Neurochemistry International 87 (2015): 106-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937630250&partnerID=MN8TOARS.
    10.1016/j.neuint.2015.06.005
  14. Serpa, A.; Sebastião, A.M.; Cascalheira, J.F.. "Modulation of cGMP accumulation by adenosine A1 receptors at the hippocampus: Influence of cGMP levels and gender". European Journal of Pharmacology 744 (2015): 83-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-84918823143&partnerID=MN8TOARS.
    10.1016/j.ejphar.2014.09.045
  15. Cascalheira, J.F.; Gonçalves, M.; Barroso, M.; Castro, R.; Palmeira, M.; Serpa, A.; Dias-Cabral, A.C.; Domingues, F.C.; Almeida, S.. "Association of the transcobalamin II gene 776C¿G polymorphism with Alzheimer’s type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A¿C polymorphism genotype". Annals of Clinical Biochemistry 52 4 (2015): 448-455. http://www.scopus.com/inward/record.url?eid=2-s2.0-84931056260&partnerID=MN8TOARS.
    10.1177/0004563214561770
  16. Cascalheira, José. "The 5,10-methylenetetrahydrofolate reductase 1298A>C polymorphism genotype influences the association of cortisol serum levels to Alzheimer’s type dementia". FEBS JOURNAL 279 S1 (2012): 384.
  17. Cascalheira, José. "Additive inhibitory modulation of cAMP accumulation in the hippocampus by the adenosine A1 and cannabinoid CB1 receptors is independent of A1 receptor desensitization". FEBS JOURNAL 279 S1 (2012): 385.
  18. Serpa, A.; Correia, S.; Ribeiro, J. A.; Sebastiao, A. M.; Cascalheira, J. F.. "Additive inhibitory modulation of cAMP accumulation in the hippocampus by the adenosine A1 and cannabinoid CB1 receptors is independent of A1 receptor desensitization". The FEBS Journal (2012): https://publons.com/wos-op/publon/59202279/.
  19. Aguilar, P.P.; Nunes, C.A.; Cascalheira, J.F.; Dias-Cabral, A.C.. "Kinetics of Angiotensin I alteration of conformation on different hydrophobic interaction chromatographic surfaces". Journal of Chromatography A 1218 46 (2011): 8322-8332. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054859407&partnerID=MN8TOARS.
    10.1016/j.chroma.2011.09.024
  20. Cascalheira, José F.; João, Sara S.; Pinhanços, Sandra S.; Castro, Rita; Palmeira, Manuela; Almeida, Sofia; Faria, Maria C.; Domingues, Fernanda C.. "Serum homocysteine: Interplay with other circulating and genetic factors in association to Alzheimer's type dementia". Clinical Biochemistry 42 9 (2009): 783-790. http://dx.doi.org/10.1016/j.clinbiochem.2009.02.006.
    10.1016/j.clinbiochem.2009.02.006
  21. Cascalheira, J.F.; Parreira, M.C.; Viegas, A.N.; Faria, M.C.; Domingues, F.C.. "Serum homocysteine: Relationship with circulating levels of cortisol and ascorbate". Annals of Nutrition and Metabolism 53 1 (2008): 67-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-52649102525&partnerID=MN8TOARS.
    10.1159/000158636
  22. Cascalheira, José. "Association of homocysteine, vitamin B12, MTHFR genetic polymorphisms and estradiol with Alzheimer's type dementia". FEBS JOURNAL 275 S1 (2008): 376.
  23. Cascalheira, J.F.; Sebastião, A.M.; Ribeiro, J.A.. "Pertussis toxin-sensitive G proteins mediate the inhibition of basal phosphoinositide metabolism caused by adenosine A1 receptors in rat hippocampal slices". Neurochemical Research 27 12 (2002): 1707-1711. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036912111&partnerID=MN8TOARS.
    10.1023/A:1021603614916
  24. Cascalheira, José. "Adenosine A1 receptor inhibition of basal phosphatidylinositol metabolism is pertussis toxin-sensitive". Eur. J. Biochemistry 268 S1 (2001): 98P.
  25. Sebastiao, A.M.; Cunha, R.A.; Cascalheira, J.F.; Ribeiro, J.A.. "Adenine nucleotides as inhibitors of synaptic transmission: Role of localised ectonucleotidases". Progress in Brain Research 120 (1999): 183-192. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032881106&partnerID=MN8TOARS.
  26. Cascalheira, J.F.; Queiroz, J.A.. "Kinetic study of the cellobiase activity of Trichoderma reesei cellulase complex at high substrate concentrations". Biotechnology Letters 21 8 (1999): 651-655. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032854876&partnerID=MN8TOARS.
    10.1023/A:1005525015777
  27. Cascalheira, J.F.; Sebastião, A.M.. "Adenosine A1 receptor activation inhibits basal accumulation of inositol phosphates in rat hippocampus". Pharmacology and Toxicology 82 4 (1998): 189-192. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031596913&partnerID=MN8TOARS.
    10.1111/j.1600-0773.1998.tb01423.x
  28. Cascalheira, JosF.; Sebastião, A.M.. "Adenine nucleotide analogues, including ¿-phosphate-substituted analogues, are metabolised extracellularly in innervated frog sartorius muscle". European Journal of Pharmacology 222 1 (1992): 49-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026493732&partnerID=MN8TOARS.
    10.1016/0014-2999(92)90462-D
  29. Cascalheira, José. "Role of Ecto-Adenylate Kinase on AMP Formation from ADP at the Innervated Sartorius Muscle of the Frog". British Journal of Pharmacology 105 (1992): 175P.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019 Differential effects of adenosine on human astrocyte and glioblastoma cell proliferation 2nd FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications
(Luso, Portugal)
2019 Taste receptors in glioblastoma: expression profile, signalling and impact on cell proliferation 2nd FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications
(Luso, Portugal)
2018 Seeking for Alzheimer’s disease risk factors and therapies Encontro Ciência 2018
(Lisboa)
2012 Kinetics of Angiotensin I alteration of conformation on different hydrophobic interaction chromatographic surfaces Presented at the 7th National Meeting on Chromatography
(Porto, Portugal)
2008 Association of Homocysteine, Estradiol, Uric Acid and Cholesterol with Alzheimer’s Type Dementia 3rd Workshop of Clinical Biochemistry
(Porto, Portugal)
1990 Structure-Activity Requirements of Ectonucleotidases at the Innervated Frog Sartorius Muscle: Use of ATP Analogues V National Congress of Biotechnology
(Braga, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020 - 2021 Efeitos antiproliferativos da metformina e adenosina em glioblastoma
Co-supervisor of Francisca Isabel Canelas Oliva Teles
 Mestrado em Bioquímica (Master)
Universidade da Beira Interior, Portugal
2019 - 2020 Avaliação da Expressão das Enzimas Envolvidas No Metabolismo da Adenosina Em Linhas Celulares de Glioblastoma e Em Astrócitos
Supervisor of Ana Cláudia Batista Honório
 Mestrado em Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2019 - 2020 Efeito anti tumoral dos canabinoides em glioblastoma: modulação pela adenosina
Co-supervisor of Carolina Boialvo Rosa
 Mestrado em Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2019 - 2020 Role of adenosine on the resistance to temozolomide anti-tumor agent in glioblastoma
Supervisor of Vanda Cristina Simões Nogueira
 Mestrado em Bioquímica (Master)
Universidade da Beira Interior, Portugal
2010 - 2015 Relationship between the adenosine A1 receptor and cGMP levels in the hippocampus: implications on neurotransmission and synaptic plasticity
Supervisor of André Santos Romão Piques Serpa
 Doutoramento em Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2013 - 2014 The role of cGMP on adenosine A1 receptor-mediated inhibition of synaptic transmission at the hippocampus
Supervisor of Isa Eunice Costa Figueiredo Paula Pinto
 Mestrado em Bioquímica (Master)
Universidade da Beira Interior, Portugal
2010 - 2011 Efeito neuroprotector de diferentes tipos de pré-condicionamento a insultos isquémicos
Supervisor of Blandina Isabel Oliveira Esteves
 Mestrado em Bioquímica (Master)
Universidade da Beira Interior, Portugal
2009 - 2010 Estudo da associação dos níveis séricos de homocisteína, alguns factores vitamínicos e hormonais e de alguns factores genéticos com a patologia do tipo Alzheimer
Supervisor of Mónica Rafaela Correia Gonçalves
 Mestrado em Bioquímica (Master)
Universidade da Beira Interior, Portugal
2009 - 2010 Efeito do óxido nítrico na proteína tau: implicação na doença de Alzheimer
Co-supervisor of Sara Isabel dos Santos Pinheiro
 Mestrado em Bioquímica (Master)
Universidade da Beira Interior, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022 Taste signalling in glioblastoma
Thesis Member
 Ana Raquel Ferreira da Costa (PhD)
Universidade da Beira Interior, Portugal
2020/09/04 Cannabinoid CB1 receptors modulation of hippocampal synaplic plasticity and the cross-talk with adenosine A1 receptors
(Thesis) Arguer
 Armando Dulcídio da Silva Cruz (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal

Conference scientific committee

Conference name Conference host
2019 - Current III International Congress in Health Sciences Research – towards innovation and entrepreneurship: Trends in Aging and Cancer Covilhã