???global.info.a_carregar???
Group: Intelligent Systems. Research Topics: - Machine Learning; Artificial Neural Networks; Bioinformatics. Google Scholar: https://scholar.google.com/citations?user=rcmwhPMAAAAJ Ludwig Krippahl completed his MsC in Artificial Intelligence in 2000 and his PhD in Structural Biochemistry in 2003 by Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia. Published 21 articles in journals. Has 2 section(s) of books and 10 book(s). Has received the 2006 IBM scientific award and participated as Principal investigator in 1 project and Researcher in 3 projects. Selected Publications: - BiGGER: a new (soft) docking algorithm for predicting protein interactions. PN Palma, L Krippahl, JE Wampler, JJG Moura, Proteins: Structure, Function, and Bioinformatics (2000), 39 (4), 372-384 - de Almeida, M. P., Quaresma, P., Sousa, S., Couto, C., Gomes, I., Krippahl, L., ... & Pereira, E. (2018). Measurement of adsorption constants of laccase on gold nanoparticles to evaluate the enhancement in enzyme activity of adsorbed laccase. Physical Chemistry Chemical Physics, 20(24), 16761-16769. - Krippahl, L., & Barahona, P. (2015). Protein docking with predicted constraints. Algorithms for Molecular Biology, 10(1), 1-8. - Morelli, X., Dolla, A., Czjzek, M., Palma, P. N., Blasco, F., Krippahl, L., ... & Guerlesquin, F. (2000). Heteronuclear NMR and soft docking: an experimental approach for a structural model of the cytochrome c 553- Ferredoxin Complex. Biochemistry, 39(10), 2530-2537. -Krippahl, L., Moura, J. J., & Palma, P. N. (2003). Modeling protein complexes with BiGGER. Proteins: Structure, Function, and Bioinformatics, 52(1), 19-23.
Read full resume ↓
Identification

Personal identification

Full name
Ludwig Krippahl

Citation names

  • Krippahl, Ludwig

Author identifiers

Ciência ID
B41F-3E93-E206
ORCID iD
0000-0002-3774-8624
Google Scholar ID
rcmwhPMAAAAJ

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2003
Concluded
 Bioquímica estrutural (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Integrating Protein Structural Information." (THESIS/DISSERTATION)
 Aprovado por unanimidade
2000
Concluded
 Inteligência Artificial Aplicada (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 Muito Bom por Unanimidade
1997
Concluded
 Química Aplicada (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 14 valores
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2015 - 2022/08/31 Assistant Professor (University Teacher) Universidade Nova de Lisboa, Portugal
Projects

Contract

Designation Funders
2021/03/01 - 2024/02/29 Multi-omic networks in gliomas
PTDC/CCI-BIO/4180/2020
Researcher
Universidade do Minho, Portugal

Universidade Nova de Lisboa NOVAMath, Portugal

Instituto de Telecomunicações Lisboa, Portugal

Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/04/01 - 2023/03/31 A machine learning-based forecasting system for shellfish safety
DSAIPA/DS/0026/2019
Researcher
Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal

Universidade Nova de Lisboa Laboratório para a Ciência da Computação e Informática, Portugal

Instituto Português do Mar e da Atmosfera, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/10/01 - 2022/06/30 Detecção de biomarcadores de stress físico e emocional através de técnicas não invasivas
PTDC/SAU-SOC/28390/2017
Centro Tecnológico das Indústrias Têxtil e do Vestuário de Portugal, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/10/01 - 2021/09/30 Detecção de biomarcadores de stress físico e emocional através de técnicas não invasivas, PTDC/SAU-SOC/28390/2017
PTDC/SAU-SOC/28390/2017
Researcher
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 NOVA Laboratory for Computer Science and Informatics
UID/CEC/04516/2019
Researcher
Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade Nova de Lisboa Laboratório para a Ciência da Computação e Informática, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Projecto Estratégico - UI 526 - 2011-2012
PEst-OE/EEI/UI0526/2011
Researcher
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Laboratório para a Ciência da Computação e Informática, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/06/30 CREMA: Refinamento de alinhamentos múltiplos por restrições para identificação de correlações entre mutações
PTDC/EIA-CCO/115999/2009
Principal investigator
Universidade Nova de Lisboa Laboratório para a Ciência da Computação e Informática, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/04/01 - 2011/12/31 Estudos estruturais dos mecanismos de localização de mRNA
PTDC/BIA-PRO/80486/2006
Researcher
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/09/01 - 2008/08/31 INTERACÇÕES PROTEÍNA / PROTEÍNA - Soft Docking, RMN e outras restricções
POCI/QUI/57741/2004
Researcher
Portuguesa Centro de Biotecnologia e Química Fina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/10/01 - 2008/06/30 Mecanismos e Energética do Transporte de Electrões em Metaloproteínas por Voltametria Dinâmica
POCI/QUI/55743/2004
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2000/10/01 - 2004/03/30 PROTEÍNA - Melhorar a Programação por Restrições para Previsão da Estrutura de Proteínas
POSI/SRI/33794/2000
Researcher
Universidade Nova de Lisboa Laboratório para a Ciência da Computação e Informática, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. João Paulo Sousa; Nunes, Maria João; Gabriel de Nóbrega Valério; Moura, José J. G. ; Krippahl, Ludwig; Alejandro K. Samhan Arias; Carlos Rouco; Cordas, Cristina M.. "Military Healthcare During Physical Exercises ¿ Monitoring human stress biomarkers in sweat". Paper presented in 8thEuChemS Chemistry Congress (ECC8), Lisbon, 2022.
    Published
  2. Gilda Santos; Maria João Nunes; Gabriel N. Valério; Alejandro Samhan-Arias; Krippahl, Ludwig; José J. G. Moura; João Paulo Sousa; Carlos Rouco; Cordas, Cristina. "Stress Sensing Based on Sweat Biomarkers Analysis for Integration in Textiles - The STRESSENSE Project". Paper presented in IFAST - International Forum on Advanced and digitalised Smart Textiles, Online edition, 2022.
    Published
  3. Costa, Carlos; Cadete, João; Peixoto de Almeida, Miguel; Pereira, Eulália; Krippahl, Ludwig; Franco, Ricardo. "Interaction between gold nanoparticles and blood proteins". Paper presented in Fourth International Congress of CiiEM: Health, Well-Being and Ageing in the 21st Century, Almada, 2021.
    Published • 10.1080/07853890.2021.1896884
  4. Peitinho, David J.; Peixoto de Almeida, Miguel; Pereira, Eulália; Krippahl, Ludwig; Franco, Ricardo. "Interaction between gold nanoparticles and blood proteins to define disease states". Paper presented in 3rd International Congress of the CiiEM, Almada, 2019.
    Published • 10.1080/07853890.2018.1561803
  5. Simone Dell'Acqua; Pauleta, Sofia R.; Krippahl, Ludwig; Alice S. Pereira; Isabel Moura; José J. G. Moura. "Electron transfer complex between cytochrome c552 and N2O reductase (N2OR) from Pseudomonas nautica.". Paper presented in J. Biol. Inorg. Chem., 2007.
    Published
  6. Pettigrew, Graham W.; Celia F. Goodhew; Pauleta, Sofia R.; Cristina Costa; Isabel Moura; José J. G. Moura; Nuno Palma; et al. "Cytochrome c peroxidase and its redox partners ¿ binary and ternary complexes.". Paper presented in J. Inorg. Biochem., 2001.
    Published
Conference paper
  1. Cordas, Cristina M.; Nunes, M. João; Valério, Gabriel N.; Samhan-Arias, Alejandro; Krippahl, Ludwig; Moura, José J. G.; Santos, Gilda; Sousa, João P.; Rouco, Carlos. "Sweat as a Testing Analytical Fluid for Emotions and Stress Biomarkers Detection". Paper presented in MICRADS 2022, 2022.
    Published • 10.1007/978-981-19-7689-6_7
  2. Ferreira, Ricardo; Lopes, Carolina; Gonçalves, Ricardo; Knorr, Matthias; Krippahl, Ludwig; Leite, Joao. "Deep Neural Networks for Approximating Stream Reasoning with C-SPARQL". Paper presented in EPIA Conference on Artificial Intelligence, 2021.
  3. Cordas, Cristina M.; João Nunes, M.; Valério, Gabriel N.; Samhan-Arias, Alejandro; Krippahl, Ludwig; Moura, José J. G.; Santos, Gilda; Sousa, João P.; Rouco, Carlos. Corresponding author: Cordas, Cristina M.. "Stress Biomarkers Detection Using Non-invasive Methods for Textiles Integrated Sensors Development". Paper presented in MICRADS 2021, 2021.
    Published • 10.1007/978-981-16-4884-7_21
  4. Madeira, F.; Krippahl, L.. "Pycoevol: A Python workflow to study protein-protein coevolution". Paper presented in BIOSTEC 2012, 2012.
    Published
  5. Dahl, V.; Barahona, P.; Bel-Enguix, G.; Krippahl, L.. "Biological concept formation grammars: A flexible, multiagent linguistic tool for biological processes". Paper presented in ICAART 2010, 2010.
    Published
Conference poster
  1. Cordas, Cristina; Maria João Nunes; José J. G. Moura; Krippahl, Ludwig; Alejandro Samhan-Arias; Carlos Rouco; João Paulo Sousa; Gilda Santos. Corresponding author: Cordas, Cristina. "Non-invasive human stress biomarkers detection-Project Stressense". Paper presented in 3rd Workshop on Human BioMonitoring in Portugal (3rd HBM-PT), 2020.
  2. Maria João Nunes 901F-E2C8-E7A7; Gabriel N. Valério; José J. G. Moura; Cordas, Cristina; Carlos Rouco; Gilda Santos; Krippahl, Ludwig. "Stress Biomarkers Detection Through Non-Invasive Methods". Paper presented in XXVI National Meeting of the Portuguese Society of Chemistry, 2019.
  3. Peixoto de Almeida, Miguel; Quaresma, Pedro; Sousa, Susana; Couto, Cláudia; Gomes, Inês; Krippahl, Ludwig; Franco, Ricardo; Pereira, Eulália. "Nanobioconjugation of Toxicodendron vernicifluum Laccase and Gold Nanoparticles for Enzymatic Activity Enhancement". Paper presented in 6th PYCHEM, 2018.
Journal article
  1. Cruz, Rafaela C.; Costa, Pedro R.; Krippahl, Ludwig; Lopes, M.B.. "Forecasting biotoxin contamination in mussels across production areas of the Portuguese coast with Artificial Neural Networks". Knowledge-Based Systems (2022): 109895.
    Published • 10.1016/j.knosys.2022.109895
  2. Rafaela C. Cruz; Pedro Reis Costa; Susana Vinga; Ludwig Krippahl; Marta B. Lopes. "A Review of Recent Machine Learning Advances for Forecasting Harmful Algal Blooms and Shellfish Contamination". Journal of Marine Science and Engineering 9 (2021): 283. https://www.mdpi.com/2077-1312/9/3/283.
    Published • 10.3390/jmse9030283
  3. Peixoto de Almeida, Miguel; Quaresma, Pedro; Sousa, Susana; Couto, Cláudia; Gomes, Inês; Krippahl, Ludwig; Franco, Ricardo; Pereira, Eulália. "Measurement of adsorption constants of laccase on gold nanoparticles to evaluate the enhancement in enzyme activity of adsorbed laccase". Physical Chemistry Chemical Physics 20 24 (2018): 16761-16769. http://dx.doi.org/10.1039/c8cp03116a.
    Published • 10.1039/c8cp03116a
  4. Krippahl, Ludwig. "Predicting Protein-Protein Interactions Using BiGGER: Case Studies". Molecules (2016): http://www.mdpi.com/1420-3049/21/8/1037.
    Published • 10.3390/molecules21081037
  5. Krippahl, L.; Barahona, P.. "Protein docking with predicted constraints". Algorithms for Molecular Biology 10 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84924238209&partnerID=MN8TOARS.
    Published • 10.1186/s13015-015-0036-6
  6. Barahona, P.; Bel-Enguix, G.; Dahl, V.; Jiménez-López, M.D.; Krippahl, L.. "Generation of classification trees from variable weighted features". Natural Computing 13 2 (2014): 169-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903596081&partnerID=MN8TOARS.
    Published • 10.1007/s11047-013-9368-7
  7. Milheiriço, C.; Portelinha, A.; Krippahl, L.; De Lencastre, H.; Oliveira, D.C.. "Evidence for a purifying selection acting on the -lactamase locus in epidemic clones of methicillin-resistant Staphylococcus aureus". BMC Microbiology 11 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79955081846&partnerID=MN8TOARS.
    Published • 10.1186/1471-2180-11-76
  8. Barahona, P.; Krippahl, L.. "Constraint programming in structural bioinformatics". Constraints 13 1-2 (2008): 3-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-43049168894&partnerID=MN8TOARS.
    Published • 10.1007/s10601-007-9036-6
  9. Monaco, S.; Gioia, M.; Rodriguez, J.; Fasciglione, G.F.; Di Pierro, D.; Lupidi, G.; Krippahl, L.; Marini, S.; Coletta, M.. "Modulation of the proteolytic activity of matrix metalloproteinase-2 (gelatinase A) on fibrinogen". Biochemical Journal 402 3 (2007): 503-513. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947236451&partnerID=MN8TOARS.
    Published • 10.1042/BJ20061064
  10. Krippahl, L.; Palma, P.N.; Moura, I.; Moura, J.J.G.. "Modelling the electron-transfer complex between aldehyde oxidoreductase and flavodoxin". European Journal of Inorganic Chemistry 19 (2006): 3835-3840. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749823924&partnerID=MN8TOARS.
    Published • 10.1002/ejic.200600418
  11. Palma, P.N.; Lagoutte, B.; Krippahl, L.; Moura, J.J.G.; Guerlesquin, F.. "Synechocystis ferredoxin/ferredoxin-NADP+-reductase/NADP+complex: Structural model obtained by NMR-restrained docking". FEBS Letters 579 21 (2005): 4585-4590. http://www.scopus.com/inward/record.url?eid=2-s2.0-24044434598&partnerID=MN8TOARS.
    Published • 10.1016/j.febslet.2005.07.027
  12. Impagliazzo, A.; Krippahl, L.; Ubbink, M.. "Pseudoazurin-nitrite reductase interactions". ChemBioChem 6 9 (2005): 1648-1653. http://www.scopus.com/inward/record.url?eid=2-s2.0-24744461441&partnerID=MN8TOARS.
    Published • 10.1002/cbic.200500082
  13. Correia dos Santos, M.M.; Paes de Sousa, P.M.; Simões Gonçalves, M.L.; Krippahl, L.; Moura, J.J.G.; Lojou, E.; Bianco, P.. "Electrochemical studies on small electron transfer proteins using membrane electrodes". Journal of Electroanalytical Chemistry 541 (2003): 153-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037448588&partnerID=MN8TOARS.
    Published • 10.1016/S0022-0728(02)01427-4
  14. Pettigrew, G.W.; Pauleta, S.R.; Goodhew, C.F.; Cooper, A.; Nutley, M.; Jumel, K.; Harding, S.E.; et al. "Electron Transfer Complexes of Cytochrome c Peroxidase from Paracoccus denitrificans Containing more than One Cytochrome". Biochemistry 42 41 (2003): 11968-11981. http://www.scopus.com/inward/record.url?eid=2-s2.0-10744222048&partnerID=MN8TOARS.
    10.1021/bi034829c
  15. Krippahl, L.; Moura, J.J.; Palma, P.N.. "Modeling protein complexes with BiGGER". Proteins: Structure, Function and Genetics 52 1 (2003): 19-23. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037683594&partnerID=MN8TOARS.
    Published • 10.1002/prot.10387
  16. Banci, L.; Bertini, I.; Felli, I.C.; Krippahl, L.; Kubicek, K.; Moura, J.J.G.; Rosato, A.. "A further investigation of the cytochrome b5-cytochrome c complex". Journal of Biological Inorganic Chemistry 8 7 (2003): 777-786. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141567641&partnerID=MN8TOARS.
    Published • 10.1007/s00775-003-0479-y
  17. Krippahl, L.; Barahona, P.. "PSICO: Solving protein structures with constraint programming and optimization". Constraints 7 3-4 (2002): 317-331. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036662961&partnerID=MN8TOARS.
    Published • 10.1023/A:1020577603762
  18. Palma, P.N.; Krippahl, L.; Wampler, J.E.; Moura, J.J.G.. "Bigger: A new (soft) docking algorithm for predicting protein interactions". Proteins: Structure, Function and Genetics 39 4 (2000): 372-384. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034212826&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0134(20000601)39:4<372::AID-PROT100>3.0.CO;2-Q
  19. Morelli, X.; Dolla, A.; Czjzek, M.; Palma, P.N.; Blasco, F.; Krippahl, L.; Moura, J.J.G.; Guerlesquin, F.. "Heteronuclear NMR and soft docking: An experimental approach for a structural model of the cytochrome c553-ferredoxin complex". Biochemistry 39 10 (2000): 2530-2537. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034646441&partnerID=MN8TOARS.
    Published • 10.1021/bi992306s
  20. Pettigrew, G.W.; Prazeres, S.; Costa, C.; Palma, N.; Krippahl, L.; Moura, I.; Moura, J.J.G.. "The structure of an electron transfer complex containing a cytochrome c and a peroxidase". Journal of Biological Chemistry 274 16 (1999): 11383-11389. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033574705&partnerID=MN8TOARS.
    Published • 10.1074/jbc.274.16.11383
  21. Pettigrew, G.W.; Gilmour, R.; Goodhew, C.F.; Hunter, D.J.B.; Devreese, B.; Van Beeumen, J.; Costa, C.; et al. "The surface-charge asymmetry and dimerisation of cytochrome c550 from Paracoccus denitrificans - Implications for the interaction with cytochrome c peroxidase". European Journal of Biochemistry 258 2 (1998): 559-566. http://www.scopus.com/inward/record.url?eid=2-s2.0-7844249042&partnerID=MN8TOARS.
    Published • 10.1046/j.1432-1327.1998.2580559.x
Preprint
  1. Tavares, Sérgio; Costa, Pedro Reis; Krippahl, Ludwig; Lopes, Marta B.. "Satellite-based feature extraction and multivariate time-series prediction of biotoxin contamination in shellfish". 2023.
    10.48550/arXiv.2311.15000
Report
  1. de Sousa Ribeiro, Manuel; Krippahl, Ludwig; Leite, João. 2020. Explainable Abstract Trains Dataset. https://arxiv.org/abs/2012.12115.
Distinctions

Other distinction

2006 Prémio Científico IBM