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Degree in Biochemistry from University of Minho, Portugal (2015). Master degree in Health Sciences from the University of Minho, Portugal (2017). Attends the PhD in Health Sciences in University of Minho since 2018, in the oncobiology field. Published 4 articles in journals, one of them as first co-author. Has 1 section(s) of books and has received 1 award in an international congress at Brazil (2019). The main research interests are: molecular targeted therapies in oncology and mechanisms of resistance, specifically, receptor tyrosine kinases (RTKs) as therapeutic targets and Raf Kinase Inhibitor Protein (RKIP), namely, its biologic functions, and its potential use as theranostic marker and also as therapeutic target in different solid tumors.
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Identification

Personal identification

Full name
Diana Carneiro

Citation names

  • Diana Cardoso-Carneiro

Author identifiers

Ciência ID
B514-44C2-1092

Email addresses

  • id7787@alunos.uminho.pt (Professional)

Telephones

Telephone
  • 253604837 (Professional)

Addresses

  • ICVS/3B’s – Life and Health Sciences Research Institute/3B’s-Biomaterials, Biodegradables and biomimetics. Escola de Medicina- Universidade do Minho Campus de Gualtar , 4710-057 , Gualtar - Braga, Braga, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2018/09/01 - 2021/09/01
Ongoing
 PhD in Health Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
"Raf Kinase Inhibitory Protein (RKIP) as a modulator of tumor microenvironment and therapy response in cervical cancer" (THESIS/DISSERTATION)
2017
Concluded
 Mestrado em Ciências da Saúde (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
"Exploiting RKIP protein as a potential modulator of HER targeted therapies response in Cervical Cancer " (THESIS/DISSERTATION)
 17
2016
Concluded
 Pós graduação em Bioquímica Aplicada - Ramo Biomedicina (Pós-Graduação)
Universidade do Minho Escola de Ciências, Portugal
 16
2015
Concluded
 Bioquímica (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Metabolic alterations in Bevacizumab treated glioblastoma cells." (THESIS/DISSERTATION)
 14
Affiliation

Others

Category
Host institution 		Employer
2018/09/01 - Current PhD Student Universidade do Minho Escola de Medicina, Portugal
Universidade do Minho Escola de Medicina, Portugal
2017/10/10 - 2018/08/31 Voluntary Internship: “Exploring RKIP protein as a novel predictor of oncogene targeted therapies in cancer” Orientação: Olga Martinho, PhD Universidade do Minho Escola de Medicina, Portugal
Universidade do Minho Escola de Medicina, Portugal
2016/10/01 - 2017/10/10 Master Thesis: “Exploiting RKIP protein as a potential modulator of HER targeted therapies response in Cervical Cancer ” orientação: Olga Martinho, PhD Universidade do Minho Escola de Medicina, Portugal
Universidade do Minho Escola de Medicina, Portugal
2015/06/01 - 2016/10/01 Voluntary Internship: “Role of cancer cell metabolism in the modulation of RTKs targeted therapy response” Orientação: Olga Martinho, PhD Universidade do Minho Escola de Medicina, Portugal
Universidade do Minho Escola de Medicina, Portugal
2015/05/01 - 2015/07/01 Internship “Metabolic alterations in Bevacizumab treated glioblastoma cells” Orientação: Olga Martinho, PhD Universidade do Minho Escola de Medicina, Portugal
Universidade do Minho Escola de Medicina, Portugal
Projects

Grant

Designation Funders
2018 - 2022 Raf Kinase Inhibitory Protein (RKIP) as a modulator of tumor microenvironment and therapy response in cervical cancer
SFRH/BD/141200/2018
PhD Student Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing

Other

Designation Funders
2017 - 2018 Exploring RKIP protein as a novel predictor of oncogene targeted therapies in cancer
Volunteer Internship in the scope of the Pos-Doc fellow of my supervisor
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Diana Cardoso-Carneiro; Ana Raquel-Cunha; Joana Pinheiro; Maria Gabriela-Freitas; Patrícia Fontão; Rui Manuel Vieira Reis; Olga Catarina Lopes Martinho. "Chapter 20 - Implications of RKIP protein in cancer prognosis and therapy response: A literature update". In Prognostic and Therapeutic Applications of RKIP in Cancer, edited by Benjamim Bonavida; Stavroula Baritaki, 389-414. Elsevier, 2020.
    Published
Conference poster
  1. "Untangling the role of RKIP in NSCLC aggressiveness – an in vitro/vivo and in silico analysis". Paper presented in II ASPIC-ASEICA International Meeting –Current Trends in Precision Medicine in Cancer, virtual event, 2021.
  2. "Exploring the predictive and therapeutic value of the embryonic T-box transcription factor Brachyury in lung cancer". Paper presented in in II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer, 2021.
  3. "Role of RKIP protein in the modulation of lung cancer cell metabolism.". Paper presented in II ASPIC-ASEICA International Meeting – Current Trends in Precision Medicine in Cancer, 2021.
  4. "A proteína RKIP como um novo preditor de resposta a terapias anti-EGFR em cancro do pulmão". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia, in Porto, Portugal,, 2021.
  5. "Fator de transcrição embrionário T-box Brachyury como biomarcador de resposta e alvo terapêutico em cancro do pulmão". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia, 2021.
  6. ""Compreender a regulação e sinalização da RKIP em cancro do colo do útero: RKIP/HER loop"". Paper presented in 3° Encontro Nacional de Jovens Investigadores em Oncologia, 2021.
  7. "RKIP protein as a novel predictor of EGFR targeted therapies in lung cancer". Paper presented in EACR 2021 Congress, Innovative Cancer Science: Better Outcomes through Research, virtual event, 2021.
  8. "RKIP protein as a potential prognostic, aggressiveness and therapy response biomarker in HPV-related cancers". Paper presented in "EACR 2021 CONGRESS, Innovative Cancer Science: Better Outcomes trough research” held virtually, 2021.
  9. "Embryonic T-box transcription factor Brachyury as a predictive biomarker and therapeutic target in lung cancer". Paper presented in 27th Porto Cancer Meeting – Stemness & Metastasis: Advances in Research and Clinical Translation,, 2021.
  10. Joana Pinheiro; Maria Gabriela-Freitas; Diana Cardoso-Carneiro; Ana Raquel-Cunha; Sara Granja; Olga Catarina Lopes Martinho. "Role of RKIP protein in the modulation of cancer cells metabolism in solid tumors". Paper presented in 6th meeting of ISCaM- Braga, 2019.
  11. Diana Cardoso-Carneiro; Patrícia Vaz-Cunha; Rosete Nogueira; Ana Raquel-Cunha; Ana Carolina Peters; André Lopes Carvalho; Rui Manuel Vieira Reis; Olga Catarina Lopes Martinho. "RKIP protein as a potential prognostic, aggressiveness and therapy response biomarker in HNSCC". Paper presented in VII International Symposium on Translational Oncology- Barretos, Brazil, 2019.
  12. Ana Raquel-Cunha; Joana Pinheiro; Diana Cardoso-Carneiro; Maria Gabriela-Freitas; Rui Manuel Vieira Reis; Olga Catarina Lopes Martinho. "RKIP protein as a novel predictor of EGFR targeted therapies in lung cancer". Paper presented in Anual Meeting CINBIO - Vigo, 2019.
  13. Diana Cardoso-Carneiro; Ana Raquel-Cunha; Rosete Nogueira; Rui Manuel Vieira Reis; Olga Catarina Lopes Martinho. "RKIP protein induces HER receptors activation and positively modulate its pharmacological targeting in cervical cancer". Paper presented in ICVS Open day 2019, 2019.
  14. Ana Raquel-Cunha; Joana Pinheiro; Diana Cardoso-Carneiro; Maria Gabriela-Freitas; Rui Manuel Vieira Reis; Olga Catarina Lopes Martinho. "RKIP protein as a novel predictor of EGFR targeted therapies in lung cancer". Paper presented in ICVS Open Day 2019, 2019.
  15. Diana Cardoso-Carneiro; Ana Raquel-Cunha; Rosete Nogueira; Rui Manuel Vieira Reis; Olga Catarina Lopes Martinho. "RKIP protein induces HER receptors activation and positively modulate its pharmacological targeting in cervical cancer". Paper presented in SINAL 2018 - 9th Meeting on Signal Transduction, Lisbon-Portugal, 2018.
  16. Ana Raquel-Cunha; Nuno Alves; Diana Cardoso-Carneiro; Rui Manuel Vieira Reis; Olga Catarina Lopes Martinho. "RKIP protein as a novel predictor of EGFR targeted therapies in lung cancer". Paper presented in SINAL 2018 - 9th Meeting on Signal Transduction, Lisbon- Portugal, 2018.
  17. Diana Cardoso-Carneiro; Ana Raquel-Cunha; Rosete Nogueira; Rui Manuel Vieira Reis; Olga Catarina Lopes Martinho. "RKIP protein induces HER receptors activation and positively modulate its pharmacological targeting in cervical cancer". Paper presented in 3rd ASPIC International Congress, 2018.
  18. Diana Cardoso-Carneiro; Ana Raquel-Cunha; Rosete Nogueira; Rui Manuel Vieira Reis; Olga Catarina Lopes Martinho. "RKIP protein induces HER receptors activation and positively modulate its pharmacological targeting in cervical cancer". Paper presented in Porto Cancer Meeting 2018, 2018.
  19. Patrícia Vaz-Cunha; Diana Cardoso-Carneiro; Ana Raquel-Cunha; André Lopes Carvalho; Rui Manuel Vieira Reis; Olga Catarina Lopes Martinho. "The biological role of RKIP in head and neck cancer: an in vivo and in vitro study". Paper presented in ICVS Open Day 2018, 2018.
  20. Diana Cardoso-Carneiro; Ana Raquel-Cunha; Rosete Nogueira; Rui Manuel Vieira Reis; Olga Catarina Lopes Martinho. "RKIP protein induces HER receptors activation and positively modulate its pharmacological targeting in cervical cancer". Paper presented in ICVS Open day 2018, 2018.
  21. Ana Raquel-Cunha; Nuno Alves; Diana Cardoso-Carneiro; Rui Manuel Vieira Reis. "RKIP protein as a novel predictor of EGFR targeted therapies in lung cancer". Paper presented in ICVS Open day 2018, 2018.
  22. Vera Miranda-Gonçalves; Diana Cardoso-Carneiro; Inês Valbom; Fernanda Cury; Viviane Aline; Sara Granja; Fátima Baltazar; Rui Manuel Vieira Reis; Olga Catarina Lopes Martinho. "Understanding the cellular metabolic reprogramming associated with bevacizumab therapy in glioblastoma". Paper presented in ICVS Open day, 2017.
  23. Olga Catarina Lopes Martinho; Renato Silva-Oliveira; Fernanda Cury; Ana Martins Barbosa; Sara Granja; Adriane Feijó Evangelista; Fábio Marques; et al. "Blocking glucose metabolism enhances the effect of HER inhibitors in cervical cancer therapy". Paper presented in SPB2016 - XIX National Congress of Biochemistry 2016, 2016.
  24. Olga Catarina Lopes Martinho; Renato Silva-Oliveira; Fernanda Cury; Ana Martins Barbosa; Sara Granja; Adriane Feijó Evangelista; Vera Miranda-Gonçalves; et al. "HER receptors are important theranostic biomarkers on cervical cancer: blocking glucose metabolism enhances the therapeutic effect of HER inhibitors". Paper presented in 16th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2016), 2016.
Journal article
  1. Gabriela-Freitas; Pinheiro; Raquel-Cunha; Cardoso-Carneiro; Martinho. "RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer". Biomolecules 9 12 (2019): 769. http://dx.doi.org/10.3390/biom9120769.
    Open access • Published
  2. Raquel-Cunha, Ana; Cardoso-Carneiro, Diana; Reis, Rui M.; Martinho, Olga. "Current Status of Raf Kinase Inhibitor Protein (RKIP) in Lung Cancer: Behind RTK Signaling". Cells 8 5 (2019): 442. http://dx.doi.org/10.3390/cells8050442.
    Open access • Published
  3. Miranda-Gonçalves, Vera; Cardoso-Carneiro, Diana; Valbom, Inês; Cury, Fernanda Paula; Silva, Viviane Aline; Granja, Sara; Reis, Rui M.; Baltazar, Fátima; Martinho, Olga. "Metabolic alterations underlying Bevacizumab therapy in glioblastoma cells". Oncotarget 8 61 (2017): http://dx.doi.org/10.18632/oncotarget.21761.
    Open access • Published • 10.18632/oncotarget.21761
  4. Martinho, Olga; Silva-Oliveira, Renato; Cury, Fernanda P.; Barbosa, Ana Martins; Granja, Sara; Evangelista, Adriane Feijó; Marques, Fábio; et al. "HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors". Theranostics 7 3 (2017): 717-732. http://dx.doi.org/10.7150/thno.17154.
    10.7150/thno.17154
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/01 RKIP protein as a potential, diagnostic, prognostic, and therapeutic marker in HPV-related cancers Ciência Falada
Instituto Ciências da Vida e da Saúde, Universidade do Minho (Braga, Portugal)
2018/05/07 RKIP protein induces HER receptors activation and positively modulate its pharmacological targeting in cervical cancer Porto Cancer Meeting 2018
Instituto de Investigação e Inovação em Saúde (Porto, Portugal)

Mentoring / Tutoring

Topic Student name
2019/02/01 - 2019/05 Effects of the natural compound, Piplartin, in the metabolism of cervical cancer cell lines Mariana Beltrame (PhD student from University of São Paulo, Brazil)
2018/09/01 - 2018/12/31 RKIP protein as a potential prognostic, aggressiveness and therapy response biomarker in HNSCC Patrícia Vaz
2018/04/01 - 2018/05/31 Raf kinase inhibitor protein (RKIP) as a modulator of oncogene targeted therapies response in Cervical Cancer Gabriela Freitas (Master student)
2018/03/01 - 2018/04/01 Biological effect of RKIP expression in lung cancer cell lines Tomás Silva (BSc student)
2017/04/01 - 2017/05/31 Biological effect of RKIP expression in lung cancer cell lines Ana Raquel-Cunha
Distinctions

Award

2019 Winner Poster at VII International Symposium on Translational Oncology, Barretos, Brazil
Hospital do AMOR, Brazil