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Identification

Personal identification

Full name
João Pedro Taborda Barata

Citation names

  • Barata, João T.
  • Barata, Joao T.

Author identifiers

Ciência ID
B51D-8696-3CA2
ORCID iD
0000-0002-4826-8976
Researcher Id
D-9181-2015
Scopus Author Id
7006937224

Email addresses

  • joao_barata@medicina.ulisboa.pt (Professional)

Addresses

  • Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina de Lisboa, Edifício Egas Moniz, P3B-35, 1649-028, Lisbon, Lisbon, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2003 - 2006
Concluded
n.a. (Pós-doutoramento)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Institut Pasteur Département Immunologie, France

Utrecht University Medical Center, Netherlands
1997 - 2003
Concluded
n/a (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Interleukin-7—Mediated Signaling and its Role in the Biology of T-Cell Acute Lymphoblastic Leukemia: Potential Targets for Therapeutic Intervention. " (THESIS/DISSERTATION)
N/A
1996 - 1997
Concluded
Ph.D. Program on Basic and Applied Biology - GABBA (Curso de doutoramento (conclusão de unidades curriculares))
Universidade do Porto, Portugal
1996
Concluded
Biology (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Utilization of Molecular Assays (ELISA and RAPD-PCR) in the Characterization and Identification of the Potato Cyst-Nematodes (Globodera spp.)" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution
Employer
2006 - Current Principal Investigator (Research) Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2003 - 2006 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
(...)
1997 - 2002 Research Trainee (Research) Dana Farber Cancer Institute, United States
Dana Farber Cancer Institute, United States
1992 - 1996 Research Assistant (Research) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2020/01 - Current Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2019 Invited Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
2008 - 2009 Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal

Others

Category
Host institution
Employer
2007/07/02 - Current Accredited as competent for the practice of animal experimentation by the Portuguese Government accreditation agency (DGV – Direcção Geral de Veterinária), n.a., Portugal
2014 - 2018 FCT Investigator (Consolidator – for established independent researchers, with an outstanding curriculum and proof of leadership in their research area). Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2006 - 2008 Coordinator of the Flow Cytometry Unit Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Projects

Grant

Designation Funders
2024/04/01 - Current ALLTogether team science : development of a preclinical testing platform to improve outcomes for drug resistant T-cell Acute Lymphoblastic Leukemia
23-FKC-09
Co-Principal Investigator (Co-PI)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Prinses Máxima Centrum voor Kinderoncologie, Netherlands
European Science Foundation
Ongoing
2024/01/01 - Current Dependence of IL-7R-mediated signaling on sphingosine kinase activity in acute lymphoblastic leukemia cells as an exploitable therapeutic vulnerability
WWCR 24-0426
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Worldwide Cancer Research
Ongoing
2024/01/01 - Current Targeted chronotherapy in T-cell acute lymphoblastic leukemia
n/a
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA)
Ongoing
2024/01 - Current Dependence of IL-7R-mediated signaling on sphingosine kinase activity in acute lymphoblastic leukemia cells as an exploitable therapeutic vulnerability
WWCR 24-0426
Association for International Cancer Research
2022/06 - Current miRToTALL - A microRNA-regulated cell death-inducing gene therapy for T-cell Acute Lymphoblastic Title Leukemia
ERC-PoC-101069429
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Ongoing
2022/04 - Current IL7R hijacking by lung cancer cells
PTDC/MEC-ONC/4606/2021
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Ongoing
2021/09 - Current IL7R_LungCan - IL7R in lung cancer development, metastasis and resistance to immune checkpoint inhibitor therapy
HR21-00761
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Ongoing
2015/09 - Current IL7sigNETure - IL-7/IL-7R signaling networks in health and malignancy
CoG-648455
European Research Council
2021/01 - 2023/08 CIRCAandSIGNAL - The reciprocal regulation between the circadian molecular clock and IL7/IL7R-mediated signaling in T-cell Acute Lymphoblastic Leukemia
EXPL/MEC-HEM/0571/2021
Researcher
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01 - 2021/12 IL7RsignaTHER - Antibody-based IL-7R targeted therapies
PoC-862545
Principal investigator
Instituto de Medicina Molecular João Lobo Antunes, Portugal
European Research Council
Ongoing
2018/10 - 2021/09 NEUROMETS - Using genomics to identify novel targeted therapies in brain metastases
EXPL/MEC-HEM/0571/2021
Co-PI
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015/09 - 2021/08 IL7sigNETure - IL-7/IL-7R signaling networks in health and malignancy
CoG-648455
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
European Research Council
Ongoing
2018/06 - 2021/05 CIRCA-TO-TREAT-LEUKEMIA - Decoding the interplay between CK2, PI3K and the circadian molecular clock to better understand the biology of, and maximize targeted treatment responses in, T-cell leukemia
PTDC/MEC-HEM/31588/2017
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/10 - 2019/09 Aberrant IL7R signaling in leukemogenesis: from the basics to potential therapeutics
FAPESP/20015/2014
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/02 - 2019/02 Selective cancer cell death using a microRNA-detector system in T-cell acute lymphoblastic leukemia
n.a.
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA)
Concluded
2016/01 - 2018/12 ReTuBi - Towards outstanding research and training in tumour biology
H2020-TWINN-2015 - ReTuBi
Researcher
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
European Union
Concluded
2016/01 - 2018/12 ReTuBi - Towards outstanding research and training in tumour biology
H2020-TWINN-2015 - ReTuBi
European Union
2015/01 - 2016/01 Generating the tools to explore an idea: Does in vivo aberrant IL-7R constitutive signaling promote cancer development?
n.a.
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA)
Concluded
2012/09 - 2015/09 Dissecting the impact of IL7R gain-of-function mutations in T-cell leukemia
PTDC/SAU-ONC/122428
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2015 Do miRNAs and TAL1 crosstalk? New insights into the regulation and function of a major T-cell oncogene.
PTDC/BIM-ONC/1548
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2014 Identification of novel regulators of CK2 with impact on PTEN function in leukemia
PTDC/SAU-ONC/113202
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2012 Cell-intrinsic and microenvironmental signals intertwined: novel targets for therapeutic intervention in acute lymphoblastic leukemia?
PTDC/SAU-OBD/104816
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2012 Reciprocal regulation between TAL1 and miRNA expression in T-cell leukemia
n.a.
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Liga Portuguesa Contra o Cancro Núcleo Regional do Sul
Concluded
2009 - 2012 Regulation of ZAP-70 and PTEN activity and stability in chronic lymphocytic leukemia: prognostic and therapeutic implications.
PIC/IC/83193
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2012 Clinical implications of activation of PI3K/Akt signaling pathway in primary adult acute lymphoblastic leukemia
PIC/IC/83023
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007 - 2010 Molecular and Functional Effects of TAL1 and LMO2 Overexpression in Normal Human Hematopoietic Stem Cells: Impact on T-cell Leukemia
PTDC/SAU-OBD/69974
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007 - 2010 Can TAL1 and LMO2 Effectively Trigger T-cell Acute Leukaemia? Studies on the Functional and Molecular Consequences of TAL1/LMO2 Over-expression in Normal Human Haematopoietic and T-cell progenitors
n.a.
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Children with Cancer UK
Concluded
2005 - 2008 External and Cell-Autonomous Signals in Tumorigenesis: Potential Targets for Novel Cancer Therapies
POCI/SAU-OBS/58913
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005 - 2008 The Role of PI3K-mediated Signaling in the Biology of T-cell Acute Lymphoblastic Leukemia
n.a.
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação Calouste Gulbenkian
Concluded
2005 - 2008 The Role of Microenvironmental Factors in Leukemogenesis: Biological Implications of Interleukin-7 Signaling and Potential for the Development of Novel Therapeutic Strategies
n.a.
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Associação Portuguesa Contra a Leucecmia
Concluded
2005 - 2008 The role of IL-7 in the homeostatic regulation of CD4+ T lymphocyte populations in humans
POCI/BIA-BCM/61079
Researcher
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2001 - 2004 TARGETING SIGNALING PATHWAYS AS THERAPY FOR HUMAN CANCER
POCTI/CBO/34914
Researcher
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2019 - 2021 Explore the role of CHK1 and the importance of CHK1 targeted therapy in AML
n.a.
co-PI
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Concluded

Other

Designation Funders
2024/03/01 - Current Interleukin-7 receptor-mediated regulation of lipid metabolism as a potential target for therapeutic intervention in acute lymphoblastic leukemia
Grant 21717
Principal investigator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Gilead Grants Program
Ongoing
Outputs

Publications

Book chapter
  1. Barata, João T.; Mariana L. Oliveira. "Cell Signaling in Cancer". In Molecular and Cell Biology of Cancer When Cells Break the Rules and Hijack Their Own Planet, 31-49. Springer, 2019.
    Published • 10.1007/978-3-030-11812-9
Conference paper
  1. Barata, João T.. "Leukemia Cells and The Bone Marrow Endothelium". 2008.
    Published
  2. Barata, João T.. "Plant-parasitic nematodes associated with fig trees in Portugal.". 1994.
    Published
Journal article
  1. Barata, João T.. "Anatomy of a crime: how IL7R and NRAS join forces to drive T-cell acute lymphoblastic leukemia". Haematologica (2024): http://dx.doi.org/10.3324/haematol.2023.284660.
    10.3324/haematol.2023.284660
  2. João T. Barata. "Darwin, MSI2, and relapse in T-ALL". Blood (2024): https://doi.org/10.1182/blood.2023022490.
    10.1182/blood.2023022490
  3. Sumaria, N; Fiala, G.J.; Inácio, D.; Curado-Avelar, M; Cachucho, Ana; Pinheiro, R; Wiesheu, R; et al. "Perinatal thymic-derived CD8aß-expressing d¿ T cells are innate interferon-¿ producers that expand in immune responses and in IL-7R/STAT5B-driven neoplasms.". Nature Immunology (2024):
    Open access • Accepted
  4. Fernandes, Marta; Gomes, A.M.; Mariana L. Oliveira; Caldas, J; Lúcio, P; Kim, R; Caye-Eude, A; et al. "Differential activation of basal and IL-7-induced PI3K/Akt/mTOR and JAK/STAT5 signaling distinguishes pediatric from adult acute lymphoblastic leukemia". Haematologica (2024):
    Open access • Accepted
  5. Cardoso, Bruno A.; Duque, Mafalda; Gírio, Ana; Fragoso, Rita; Oliveira, Mariana L.; Allen, James R.; Martins, Leila R.; et al. "CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia". Haematologica (2023): http://dx.doi.org/10.3324/haematol.2023.282854.
    10.3324/haematol.2023.282854
  6. Garcia, Ana Rita; Mendes, Avilson; Custódia, Carlos; Faria, Cláudia C.; Barata, João T.; Malhó, Rui; Figueira, Inês; Brito, Maria Alexandra. "Abrogating Metastatic Properties of Triple-Negative Breast Cancer Cells by EGFR and PI3K Dual Inhibitors". Cancers 15 15 (2023): 3973. http://dx.doi.org/10.3390/cancers15153973.
    10.3390/cancers15153973
  7. Moës, Bastien; Li, Hua; Molina-Ortiz, Patricia; Radermecker, Coraline; Rosu, Adeline; Vande Catsyne, Charles-Andrew; Sayyed, Sufyan Ali; et al. "INPP5K controls the dynamic structure and signaling of wild-type and mutated, leukemia-associated IL-7 receptors". Blood 141 14 (2023): 1708-1717. http://dx.doi.org/10.1182/blood.2022017819.
    10.1182/blood.2022017819
  8. Paisana, Eunice; Cascão, Rita; Custódia, Carlos; Qin, Nan; Picard, Daniel; Pauck, David; Carvalho, Tânia; et al. "UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease". Neuro-Oncology Advances 5 1 (2023): http://dx.doi.org/10.1093/noajnl/vdad048.
    10.1093/noajnl/vdad048
  9. Marta B. Fernandes; João T. Barata. "IL-7 and IL-7R in health and disease: An update through COVID times". Advances in Biological Regulation (2023): https://doi.org/10.1016/j.jbior.2022.100940.
    10.1016/j.jbior.2022.100940
  10. Blümel, Lena; Qin, Nan; Berlandi, Johannes; Paisana, Eunice; Cascão, Rita; Custódia, Carlos; Pauck, David; et al. "Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors". Cell Death & Disease 13 9 (2022): http://dx.doi.org/10.1038/s41419-022-05243-4.
    10.1038/s41419-022-05243-4
  11. Fernandes, Marta B.; Barata, João T.. "Surprise, surprise: STAT5 is not enough to stop the steroids". Haematologica 108 3 (2022): 670-672. http://dx.doi.org/10.3324/haematol.2022.281369.
    10.3324/haematol.2022.281369
  12. Oliveira, Mariana L.; Veloso, Alexandra; Garcia, Elaine G.; Iyer, Sowmya; Pereira, Clara; Barreto, Vasco M.; Langenau, David M.; Barata, João T.. "Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia". Leukemia 36 6 (2022): 1533-1540. http://dx.doi.org/10.1038/s41375-022-01590-5.
    10.1038/s41375-022-01590-5
  13. Faria, Claudia C.; Cascão, Rita; Custódia, Carlos; Paisana, Eunice; Carvalho, Tânia; Pereira, Pedro; Roque, Rafael; et al. "Patient-derived models of brain metastases recapitulate human disseminated disease". Cell Reports Medicine 3 5 (2022): 100623. http://dx.doi.org/10.1016/j.xcrm.2022.100623.
    10.1016/j.xcrm.2022.100623
  14. Qin, Nan; Paisana, Eunice; Langini, Maike; Picard, Daniel; Malzkorn, Bastian; Custódia, Carlos; Cascão, Rita; et al. "Intratumoral heterogeneity of MYC drives medulloblastoma metastasis and angiogenesis". Neuro-Oncology 24 9 (2022): 1509-1523. http://dx.doi.org/10.1093/neuonc/noac068.
    10.1093/neuonc/noac068
  15. Nunes-Cabaço, Helena; Ramalho-dos-Santos, Andreia; Pires, Ana R.; Martins, Leila R.; Barata, João T.; Sousa, Ana E.. "Human CD4 T Cells From Thymus and Cord Blood Are Convertible Into CD8 T Cells by IL-4". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.834033.
    10.3389/fimmu.2022.834033
  16. Geron, Ifat; Savino, Angela Maria; Fishman, Hila; Tal, Noa; Brown, John; Turati, Virginia A.; James, Chela; et al. "An instructive role for Interleukin-7 receptor a in the development of human B-cell precursor leukemia". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-28218-7.
    10.1038/s41467-022-28218-7
  17. Almeida, Afonso R. M.; Neto, João L.; Cachucho, Ana; Euzébio, Mayara; Meng, Xiangyu; Kim, Rathana; Fernandes, Marta B.; et al. "Interleukin-7 receptor a mutational activation can initiate precursor B-cell acute lymphoblastic leukemia". Nature Communications 12 1 (2021): http://dx.doi.org/10.1038/s41467-021-27197-5.
    10.1038/s41467-021-27197-5
  18. Silva, Ana; Almeida, Afonso R. M.; Cachucho, Ana; Neto, João L.; Demeyer, Sofie; de Matos, Mafalda; Hogan, Thea; et al. "Overexpression of wild-type IL-7Ra promotes T-cell acute lymphoblastic leukemia/lymphoma". Blood 138 12 (2021): 1040-1052. http://dx.doi.org/10.1182/blood.2019000553.
    10.1182/blood.2019000553
  19. "Immunophenotype of Gastric Tumors Unveils a Pleiotropic Role of Regulatory T Cells in Tumor Development.". Cancers (2021): https://europepmc.org/articles/PMC7865950.
    10.3390/cancers13030421
  20. "PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis.". Leukemia (2020): https://europepmc.org/articles/PMC8009053.
    10.1038/s41375-020-0937-3
  21. "Clinical-Grade Peptide-Based Inhibition of CK2 Blocks Viability and Proliferation of T-ALL Cells and Counteracts IL-7 Stimulation and Stromal Support.". Cancers (2020): https://europepmc.org/articles/PMC7352628.
    10.3390/cancers12061377
  22. R. De Smedt; J. Morscio; L. Reunes; J. Roels; V. Bardelli; B. Lintermans; W. Van Loocke; et al. "Targeting cytokine and therapy induced PIM1 activation in T-cell acute lymphoblastic leukemia and lymphoma.". Blood (2020): https://doi.org/10.1182/blood.2019003880.
    Published • 10.1182/blood.2019003880
  23. Julie A. Hixon; Caroline Andrews; Lila Kashi; Casey L. Kohnhorst; Emilee Senkevitch; Kelli Czarra; Joao T. Barata; et al. "New anti-IL-7Ra monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models". Leukemia (2020): https://doi.org/10.1038/s41375-019-0531-8.
    10.1038/s41375-019-0531-8
  24. Inês Pinto; Mafalda Duque; Joana Gonçalves; Padma Akkapeddi; Mariana L. Oliveira; Rita Cabrita; J. Andrés Yunes; et al. "NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling". Oncogene 39 5 (2020): 975-986. https://doi.org/10.1038/s41388-019-1042-9.
    10.1038/s41388-019-1042-9
  25. João T. Barata; Scott K. Durum; Benedict Seddon. "Flip the coin: IL-7 and IL-7R in health and disease". Nature Immunology 20 12 (2019): 1584-1593. https://doi.org/10.1038/s41590-019-0479-x.
    10.1038/s41590-019-0479-x
  26. Oliveira, M.L.; Akkapeddi, P.; Ribeiro, D.; Melão, A.; Barata, J.T.. "IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update". Advances in Biological Regulation (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85053785591&partnerID=MN8TOARS.
    Published • 10.1016/j.jbior.2018.09.012
  27. Daniel Ribeiro; Alice Melão; Ruben van Boxtel; Cristina I. Santos; Ana Silva; Milene C. Silva; Bruno A. Cardoso; Paul J. Coffer; João T. Barata. "STAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells". Blood Advances 2 17 (2018): 2199-2213. https://doi.org/10.1182/bloodadvances.2018021063.
    10.1182/bloodadvances.2018021063
  28. Evangelisti, C.; Cappellini, A.; Oliveira, M.; Fragoso, R.; Barata, J.T.; Bertaina, A.; Locatelli, F.; et al. "Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia". Journal of Cellular Physiology 233 3 (2018): 1796-1811. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028947826&partnerID=MN8TOARS.
    10.1002/jcp.26135
  29. Buontempo, F.; McCubrey, J.A.; Orsini, E.; Ruzzene, M.; Cappellini, A.; Lonetti, A.; Evangelisti, C.; et al. "Therapeutic targeting of CK2 in acute and chronic leukemias". Leukemia 32 1 (2017): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042018500&partnerID=MN8TOARS.
    10.1038/leu.2017.301
  30. Oliveira, M.L.; Akkapeddi, P.; Alcobia, I.; Almeida, A.R.; Cardoso, B.A.; Fragoso, R.; Serafim, T.L.; Barata, J.T.. "From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia". Cellular Signalling 38 (2017): 10-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021247666&partnerID=MN8TOARS.
    10.1016/j.cellsig.2017.06.011
  31. Ribeiro, S.T.; Barata, J.T.; Silva-Santos, B.. "Multifaceted CK2 in malignant and healthy T cells". Oncotarget 8 53 (2017): 90622-90623. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032709639&partnerID=MN8TOARS.
    10.18632/oncotarget.21700
  32. Ribeiro, S.T.; Tesio, M.; Ribot, J.C.; Macintyre, E.; Barata, J.T.; Silva-Santos, B.. "Casein kinase 2 controls the survival of normal thymic and leukemic ¿d T cells via promotion of AKT signaling". Leukemia 31 7 (2017): 1603-1610. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006288689&partnerID=MN8TOARS.
    10.1038/leu.2016.363
  33. Silva, S.L.; Albuquerque, A.S.; Matoso, P.; Charmeteau-de-Muylder, B.; Cheynier, R.; Ligeiro, D.; Abecasis, M.; et al. "IL-7-induced proliferation of human naive CD4 T-cells relies on continued thymic activity". Frontiers in Immunology 8 JAN (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85012181043&partnerID=MN8TOARS.
    10.3389/fimmu.2017.00020
  34. Sarmento, L.M.; Barata, J.T.. "CHK1 and replicative stress in T-cell leukemia: Can an irreverent tumor suppressor end up playing the oncogene?". Advances in Biological Regulation 60 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84958741867&partnerID=MN8TOARS.
    10.1016/j.jbior.2015.10.007
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  89. Barata, J.T.; Boussiotis, V.A.; Yunes, J.A.; Ferrando, A.A.; Moreau, L.A.; Veiga, J.P.; Sallan, S.E.; et al. "IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL". Blood 103 5 (2004): 1891-1900. http://www.scopus.com/inward/record.url?eid=2-s2.0-10744230130&partnerID=MN8TOARS.
    10.1182/blood-2002-12-3861
  90. Barata, J.T.; Keenan, T.D.; Silva, A.; Nadler, L.M.; Boussiotis, V.A.; Cardoso, A.A.. "Common ¿ chain-signaling cytokines promote proliferation of T-cell lymphoblastic leukemia". Haematologica 89 12 (2004): 1459-1467. http://www.scopus.com/inward/record.url?eid=2-s2.0-10444276464&partnerID=MN8TOARS.
  91. Barata, J.T.; Cardoso, A.A.; Nadler, L.M.; Boussiotis, V.A.. "Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27kip1". Blood 98 5 (2001): 1524-1531. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035469821&partnerID=MN8TOARS.
    10.1182/blood.V98.5.1524
Online resource
  1. Barata, João T.; Daniel Ribeiro. IL7R (interleukin 7 receptor). Atlas Genet Cytogenet Oncol Haematol. 2013. http://AtlasGeneticsOncology.org/Genes/IL7RID51090ch5p13.html.

Intellectual property

Patent
  1. 2021. "Genetic construct".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/03/22 “Da investigação fundamental à geração de novas armas terapêuticas contra a leucemia linfoblástica aguda? [From fundamental research to the generation of new therapeutic tools against acute lymphoblastic leukemia?]”, CAML (Centro Académico de Medicina de Lisboa) Sessions - What’s new in CAML, Faculdade de Medicina, Universidade de Lisboa, 22 Março (Host: Prof. João Lacerda). This talk was given together with Rita Fragoso and Mafalda Duque, from João T. Barata’s lab. CAML (Centro Académico de Medicina de Lisboa) Sessions - What’s new in CAML
Faculdade de Medicina, Universidade de Lisboa (Lisbon, Portugal)
2023/09/25 “MicroRNA-Regulated Gene Therapy Cell Death-inducing System for T-ALL”, T-ALL Biology Special Interest Group, ALLTogether Consortium Annual General Meeting, University of Strathclyde Technology and Innovation Centre, Glasgow, UK, 25-27 September. ALLTogether Consortium Annual General Meeting
University of Strathclyde Technology and Innovation Centre (Glasgow, United Kingdom)
2023/05/05 Lecture on IL-7 in immunodeficiency and in leucemia (“Entre imunodeficiência e leucemia: as duas faces da IL-7 e do seu receptor”) Immunology Course directed by Prof. Ana C. Sousa for undergraduate students
University of Évora (Évora, Portugal)
2023/04/20 JT Barata participated in the round table on job perspectives for early carreer biomedical graduates [“Saídas profissionais para os estudantes da ESDH - desafios para os próximos anos”] (together with Dr. Vítor Pataco, President of Instituto Português do Desporto e Juventude, and Dra Cristina Rubianes Vieira, Presidente of Associação Portuguesa de Psicomotricidade). DIA DA ESCOLA DE SAÚDE E DESENVOLVIMENTO HUMANO, University of Évora, Portugal, 20 April. Saídas profissionais para os estudantes da ESDH - desafios para os próximos anos
University of Évora (Évora, Portugal)
2023/03/30 “ Gone rogue: IL7R in acute lymphoblastic leukemia”, Institute of cellular and molecular radiobiology (IRCM), French Alternative Energies and Atomic Energy Commission (CEA), Fontenais-aux-Roses, Paris, France, 30 March. (Host: Dr. Françoise Pflumio)
Institute of cellular and molecular radiobiology (IRCM), French Alternative Energies and Atomic Energy Commission (CEA) (Paris, France)
2023/03/25 “Twists and turns of immune cells: Lymphoid leukemia and anti-leukemia immunotherapies” Curso de Imunologia e Imunoterapia [Immunology and Immunotherapy course]
SPFCS - Sociedade Portuguesa dos Farmacêuticos dos Cuidados da Saúde (Tomar, Portugal)
2023/02/14 Signaling in Cancer 24th JORTEC – Jornadas Tecnológicas, NOVA School of Sciences and Technology
2023/02/14 “Signaling in Cancer”, 24th JORTEC – Jornadas Tecnológicas, NOVA School of Sciences and Technology, Caparica, 14 February. Jornadas Tecnológicas
NOVA School of Sciences and Technology (Lisboa, Portugal)
2023 Sphingosine Kinases are essential positive modulators of IL7/IL-7R signaling in Acute Lymphoblastic Leukemia. M.B. Fernandes, A. Melão, T. Araújo, A. Cachucho, D.R. Adams, J. Oh, A.R.M. Almeida, F. Torta, V. Barreto, S. Pyne, T. Hla, N.J. Pyne, J.T. Barata (2023). YoungEHA Research Meeting, European Hematology Association 2023 Hybrid Congress
European Hematology Association (Frankfurt, Germany)
2023 Dependence of IL-7R-mediated signaling on sphingosine kinase activity in acute lymphoblastic leukemia, but not healthy lymphoid cells, is an exploitable therapeutic vulnerability. M.B. Fernandes, A. Melão, T. Araújo, A. Cachucho, D.R. Adams, J. Oh, A.R.M. Almeida, F. Torta, V. Barreto, S. Pyne, T. Hla, N.J. Pyne, J.T. Barata (2023). (Work was highlighted in the “Best of ASH 2023”) The American Society of Hematology 65th Annual Meeting
American Society of Hematology (San Diego, United States)
2023 Characterizing the risk for IL-7R-mediated malignancy in different stages of hematopoietic development. A. Cachucho, J. Ronchi, P. Amaral, T. Araújo, M.B. Fernandes, M. Euzébio, J.L. Neto, C. Veludo, V. Martins, A.R.M. Almeida, A. Yunes, J.T. Barata (2023). Poster Presentation. XLVIII Annual Meeting of the Portuguese Society for Immunology
Portuguese Society for Immunology (Aveiro, Portugal)
2023 Histone deacetylase inhibition abrogates IL-7R-mediated signaling by downregulating IL7R and preventing mTORC1 activation. J. Fontela, M. Oliveira, I. Alcobia, T. Serafim, A.R. Grosso, J.T. Barata (2023). (Poster Presentation). XLVIII Annual Meeting of the Portuguese Society for Immunology
Portuguese Society for Immunology (Aveiro, Portugal)
2023 Sphingosine Kinases are essential positive modulators of IL7/IL-7R signaling in Acute Lymphoblastic Leukemia. M.B. Fernandes, A. Melão, T. Araújo, A. Cachucho, D.R. Adams, J. Oh, A.R.M. Almeida, F. Torta, V. Barreto, S. Pyne, T. Hla, N.J. Pyne, Barata JT (2023). (Poster Presentation) 3rd Translational Research Conference: Acute Lymphoblastic Leukaemia
(Berlin, Germany)
2023 Development of anti-IL-7Ra antibodies as a targeted therapy for T-cell Acute Lymphoblastic Leukemia. M. Duque, J. Santos, S. Andrade, D. Teixeira, M. Pajuelo, A. Parada, R. Fragoso, Barata JT (2023). (Poster Presentation). 3rd Translational Research Conference: Acute Lymphoblastic Leukaemia
(Berlin, Germany)
2023 Development of a gene therapy cell death-inducing system regulated by microRNAs for T-cell Acute Lymphoblastic Leukemia. M. Duque, J. Silva, J.T. Barata, R. Fragoso (2023). (Poster Presentation) European Hematology Association 2023 Hybrid Congress
European Hematology Association (Frankfurt, Germany)
2023 Development of anti-IL-7Ra antibodies as a targeted therapy for T-cell Acute Lymphoblastic Leukemia. M. Duque, J. Santos, S. Andrade, D. Teixeira, M. Pajuelo, A. Parada, R. Fragoso, Barata JT (2023). (Poster Presentation). European Hematology Association 2023 Hybrid Congress
European Hematology Association (Frankfurt, Germany)
2023 Development of a gene therapy cell death-inducing system regulated by microRNAs for cancer. M. Duque, J. Silva, J.T. Barata, R. Fragoso (2023). (Poster Presentation) ESGCT 30th ANNUAL CONGRESS
(Brussels, Belgium)
2023 Sphingosine Kinases are essential positive modulators of IL7/IL-7R signaling in Acute Lymphoblastic Leukemia. M.B. Fernandes, A. Melão, T. Araújo, A. Cachucho, D.R. Adams, J. Oh, A.R.M. Almeida, F. Torta, V. Barreto, S. Pyne, T. Hla, N.J. Pyne, Barata JT (2023). (Poster Presentation). 3rd Translational Research Conference: Acute Lymphoblastic Leukaemia
(Frankfurt, Germany)
2022/12/05 Gone wild: IL-7 and IL-7R in T-cell leukemia European Federation of Immunological Societies (Study Group T-cell Connect Europe) Online Immunology Lecture series
2022/12/05 “Gone wild: IL-7 and IL-7R in T-cell leukemia”, European Federation of Immunological Societies (Study Group T-cell Connect Europe) Online Immunology Lecture series, 5 December (Online meeting). European Federation of Immunological Societies (Study Group T-cell Connect Europe) Online Immunology Lecture series
Study Group T-cell Connect Europe
2022/11/15 UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease. E. Paisana, R. Cascão, C. Custódia, N. Qin, D. Picard, D. Pauck, T. Carvalho, P. Ruivo, C. Barreto, P. Pereira, R. Roque, D. Doutel, J. Cabeçadas, J. Pimentel, J. Miguéns, M. Remke, J.T. Barata, C.C. Faria (2022). 6ª Conferência Anual da redeSAÚDE – Perspetivas Multidisciplinares e Saúde Global na Ulisboa
Universidade de Lisboa (Lisbon, Portugal)
2022/11/15 “The role of HoxA9 in IL7R-mediated B-Cell Leukemogenesis”. S. Gama, M. Duque, J.T. Barata (2022). 6ª Conferência Anual da redeSAÚDE – Perspetivas Multidisciplinares e Saúde Global na ULisboa. Lisboa
Universidade de Lisboa (Lisbon, Portugal)
2022/11/15 Histone deacetylase inhibitors as therapeutic candidates against IL-7-responsive acute lymphoblastic leukemia. J. Fontela, M. Oliveira, J.T. Barata (2022). 6ª Conferência Anual da redeSAÚDE – Perspetivas Multidisciplinares e Saúde Global na ULisboa. Lisboa
Universidade de Lisboa (Lisboa, Portugal)
2022/11/15 Crosstalk between the Circadian Molecular Clock and the CK2-PI3K signaling axis in T-ALL. P.M. Amaral, C. Gonçalves Dias, B.A. Cardoso, J.T. Barata (2022). 6ª Conferência Anual da redeSAÚDE – Perspetivas Multidisciplinares e Saúde Global na ULisboa.
Universidade de Lisboa (Lisboa, Portugal)
2022/10/04 Interleukin-7 receptor-mediated signaling can trigger acute lymphoblastic leukemia 63rd Advances in Biological Regulation Symposium
University of Bologna (Italy)
2022/10/04 “Interleukin-7 receptor-mediated signaling can trigger acute lymphoblastic leukemia”, 63rd Advances in Biological Regulation Symposium, University of Bologna, Italy, 4 – 5 October. (Other speakers: Vytas Baikantis, Sarah Spiegel) 63rd Advances in Biological Regulation Symposium
University of Bologna (Bologna, Italy)
2022/07/18 IL-7R signaling in the genesis and potential treatment of acute lymphoblastic leukemia AFFIMED
2022/07/18 “IL-7R signaling in the genesis and potential treatment of acute lymphoblastic leukemia”, AFFIMED, 18 July (online). (Host: Dr. Jan C. Schmollinger) AFFIMED
Dr. Jan C. Schmollinger (Online, Germany)
2022/05/18 “Cancer - Successes and Challenges”, Plenary Session 6, Encontro Ciência ’22 - Encontro com a Ciência e Tecnologia em Portugal [Science Meeting ’22], Lisboa, 18 May. Encontro Ciência ’22 - Encontro com a Ciência e Tecnologia em Portugal
(Portugal)
2022/04/04 “A view on how the Terry Fox award impacted our research”, VII Jornadas de Investigação em Oncologia – 25 Anos de Bolsas Terry Fox [VII Research in Oncology Meeting - 25 Years of Terry Fox Awards], Lisboa, 4 April. VII Jornadas de Investigação em Oncologia – 25 Anos de Bolsas Terry Fox [VII Research in Oncology Meeting - 25 Years of Terry Fox Awards]
Liga Portuguesa Contra o Cancro (Lisbon, Portugal)
2022/03/26 “Twists and turns of immune cells: Lymphoid leukemia and anti-leukemia immunotherapies” Curso de Imunologia e Imunoterapia [Immunology and Immunotherapy course]
SPFCS - Sociedade Portuguesa dos Farmacêuticos dos Cuidados da Saúde (Tomar, Portugal)
2022/03/04 Gone wild: IL-7 and its receptor in leukemia development 8th MCBiology Symposium
2022/03/04 “Gone wild: IL-7 and its receptor in leukemia development”, 8th MCBiology Symposium, 4 March (Online meeting). 8th MCBiology Symposium
(Online, Portugal)
2022/03/02 JT Barata participated in the session / roundtable “Tratar o cancro por tu - 4ª conferência: linfomas e leucemias [Conference on cancer for lay people: lymphomas and leukemias]”, together with Profs. Maria Gomes da Silva, Manuel Abecasis, José Carlos Machado and Manuel Sobrinho-Simões, Câmara Municipal de Lisboa [Lisbon City Hall], Portugal, 2 March. This session was broadcast by the national radio station Antena 1 to a general audience. Conference on cancer for lay people: lymphomas and leukemias
Antena 1 (Lisbon, Portugal)
2022 Patient-derived models of brain metastases are useful tools for preclinical evaluation of anticancer therapies. R. Cascão, C. Custódia, E. Paisana, I. Cortes-Ciriano, J.T. Barata, C.C. Faria (2022). (Poster Presentation). Innovative cancer Science - EACR
EACR (Seville, Spain)
2022 UBE2C-driven leptomeningeal dissemination can be abrogated by targeting the PI3K-mTOR pathway in patients with brain metastases. E. Paisana, R. Cascão, C. Custódia, N. Qin, D. Picard, D. Pauck, T. Carvalho, P. Ruivo, C. Barreto, P. Pereira, R. Roque, D. Doutel, J. Cabeçadas, J. Pimentel, J. Miguéns, M. Remke, J.T. Barata, C.C. Faria (2022). (Poster Presentation). 2022 Annual Conference on CNS Clinical Trials & Brain Metastases
SNO and ASCO (Toronto, Canada)
2021/10/14 “IL-7R signaling as a therapeutic target in acute lymphoblastic leukemia?”, II ASPIC-ASEICA International Meeting – Current Trends in Precision Medicine in Cancer, 14-15 October (online meeting). (Other speakers: Maria S. Soengas, Michael Weller, Gabri van der Pluijm, An Hendrix, Aleix Prat) II ASPIC-ASEICA International Meeting – Current Trends in Precision Medicine in Cancer
ASPIC-ASEICA
2021/10 “IL-7R signaling as a therapeutic target in acute lymphoblastic leukemia?” II ASPIC-ASEICA International Meeting – Current Trends in Precision Medicine in Cancer (online meeting)
2021/08/19 Ubiquitin Conjugating Enzymes promote leptomeningeal dissemination and decrease survival in patients with brain metastatic disease. E. Paisana, R. Cascão, C. Custódia, N. Qin, D. Picard, D. Pauck, T. Carvalho, P. Ruivo, P. Pereira, R. Roque, J. Pimentel, M. Remke, J. Miguéns, J.T. Barata, C.C. Faria (Poster presentation) SNO 3rd Annual Conference on Brain Metastases (international virtual meeting)
2021/08/19 Ubiquitin Conjugating Enzymes promote leptomeningeal dissemination and decrease survival in patients with brain metastatic disease. E. Paisana, R. Cascão, C. Custódia, N. Qin, D. Picard, D. Pauck, T. Carvalho, P. Ruivo, P. Pereira, R. Roque, J. Pimentel, M. Remke, J. Miguéns, J.T. Barata, C.C. Faria (Poster presentation) Third Annual Conference on Brain Metastases, Virtual Conference, Toronto, Canada
2021/07/08 Bridging – A integração da investigação básica na investigação clínica em Oncologia [Bridging – Integrating basic research into Clinical research in Oncology] 3ª Edição do Curso de Investigação em Oncologia [3rd Edition of the Course on Research in Oncology]
Núcleo de Internos e Jovens Especialistas da SPO [Group of Interns and Young Specialists of the Portuguese Society of Oncology] (Online Course)
2021/06/09 IL7R mutational activation can initiate Ph-Like and Pax5 P80R precursor B-cell acute lymphoblastic leukemia. A. Almeida, J.L. Neto, A. Cachucho, M. Euzébio, X. Meng, R. Kim, M.B. Fernandes, B. Raposo, M.L. Oliveira, D. Ribeiro, R. Fragoso, P.P. Zenatti, T. Soares, M.R. de Matos, J. Ronchi Corrêa, M. Duque, K.G. Roberts, Z. Gu, C. Qu, S. Pyne, N.J. Pyne, V.M. Barreto, I. Bernard-Pierrot, E. Clappier, C.G. Mullighan, A.R. Grosso, J.A. Yunes, J.T. Barata EHA 2021 - Online meeting of the European Hematology Association
2021/06/09 Checkpoint kinase 1 is overexpressed, by post-transcriptional regulation, in immature and monoblastic / monocytic acute myeloid leukemia. L.M. Sarmento, S.G. Pereira, F. Costa, A. Monteiro, J. Caldas, P. Ribeiro, J.T. Barata (Poster presentation) EHA 2021 - Online meeting of the European Hematology Association
2021/06/09 The Role of Ubiquitin Conjugating Enzymes in Brain Metastases. E. Paisana, R. Cascão, C. Custódia, N. Qin, D. Picard, P. Pereira, R. Roque, J. Pimentel, M. Remke, J. Miguéns, J.T. Barata, C.C. Faria (Poster presentation) EACR 2021 Congress, Innovative Cancer Science: Better Outcomes through Research, Virtual Conference
2021/05/20 Ubiquitin Conjugating Enzymes promote aggressive metastatic brain disease and decrease patients’ survival E. Paisana, R. Cascão, C. Custódia, N. Qin, D. Picard, T. Carvalho, P. Ruivo, P. Pereira, R. Roque, J. Pimentel, M. Remke, J. Miguéns, J.T. Barata, Cláudia C. Faria 27th Porto Cancer Meeting – Stemness and metastasis: advances in research and clinical translation
2021/05/20 Diving into the dark side of IL-7 and IL-7R and their contribution to lymphoid leukemia development XLVI Annual Meeting of The Portuguese Society of Immunology (SPI), 20-21 May (Online meeting).
2021/05/20 “Diving into the dark side of IL-7 and IL-7R and their contribution to lymphoid leukemia development”, XLVI Annual Meeting of The Portuguese Society of Immunology (SPI), 20-21 May (Online meeting). XLVI Annual Meeting of The Portuguese Society of Immunology (SPI)
Portuguese Society of Immunology
2021/05/15 Signal Transduction and Cancer: IL-7 and leukemia XI Jornadas Nacionais de Ciências Biomédicas [XI National Meeting of Biomedical Sciences] (Online meeting).
2021/05/15 “Signal Transduction and Cancer: IL-7 and leukemia”, XI Jornadas Nacionais de Ciências Biomédicas [XI National Meeting of Biomedical Sciences], 15 May (Online meeting). XI Jornadas Nacionais de Ciências Biomédicas [XI National Meeting of Biomedical Sciences]
2021/05/07 IL7R gain-of-function mutation is sufficient to initiate B-cell acute lymphoblastic leukemia in vivo with features of PAX5 P80R and Ph-like ALL. A. Almeida, J.L. Neto, A. Cachucho, M. Euzébio, X. Meng, R. Kim, M.B. Fernandes, B. Raposo, M.L. Oliveira, D. Ribeiro, R. Fragoso, P.P. Zenatti, T. Soares, M.R. de Matos, J. Ronchi Corrêa, M. Duque, K.G. Roberts, Z. Gu, C. Qu, S. Pyne, N.J. Pyne, V.M. Barreto, I. Bernard-Pierrot, E. Clappier, C.G. Mullighan, A.R. Grosso, J.A. Yunes, J.T. Barata (2021). European School of Hematology (ESH) Translational Research E-Conference ACUTE LYMPHOBLASTIC LEUKAEMIA
2021/05 “Diving into the dark side of IL-7 and IL-7R and their contribution to lymphoid leukemia development” XLVI Annual Meeting of The Portuguese Society of Immunology (SPI), 20-21 May (Online meeting).
(Online, Portugal)
2021/05 “Signal Transduction and Cancer: IL-7 and leukemia”, XI Jornadas Nacionais de Ciências Biomédicas [XI National Meeting of Biomedical Sciences], 15 May (Online meeting). XI Jornadas Nacionais de Ciências Biomédicas [XI National Meeting of Biomedical Sciences] (Online meeting).
(Online, Portugal)
2020/03 High IL-7- IL-7Ra signals promote T-cell acute lymphoblastic leukemia in mice and humans overexpressing wild type IL-7Ra. A. Almeida, A. Silva, S. Demeyer, A. Cachucho, T. Hogan, J. Meijerink, J. Cools, A.R. Grosso, B. Seddon*, J. T. Barata*. EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microevironment
EACR - European Association for Cancer Research; AACR - American Association for Cancer Research; ASPIC - Associação Portuguesa de Investigação em Cancro (Lisbon, Portugal)
2020 Sphingosine Kinases are key effectors of IL-7-mediated leukemia expansion. M. Fernandes, A. Melão, A. Almeida, S. Pyne, N.J. Pyne, J.T. Barata* (Poster presentation) EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microevironment
(Lisbon, Portugal)
2019/10/19 Overexpression of wild type IL-7Ra promotes T-cell acute lymphoblastic leukemia/lymphoma. A. Silva, A. Almeida, M. Matos, S. Demeyer, A. Cachucho, T. Hogan, Y. Li, J. Meijerink, J. Cools, A.R. Grosso, B. Seddon* and J.T. Barata* Xth SINAL meeting on Signal Transduction
SINAL - Signal Transduction Network (Olhão, Portugal)
2019/05 Overexpression of wild type IL-7Ra promotes T-cell acute lymphoblastic leukemia/lymphoma. A. Silva, A. Almeida, M. Matos, S. Demeyer, A. Cachucho, T. Hogan, Y. Li, J. Meijerink, J. Cools, A.R. Grosso, B. Seddon* and J.T. Barata* SPI 45 - 45th Annual Meeting of the Portuguese Society of Immunology
SPI - Sociedade Portuguesa de Imunologia (Coimbra, Portugal)
2019/05 Sphingosine Kinases are key effectors of IL-7R-mediated signaling, viability, growth and proliferation in T-cell Acute Lymphoblastic Leukemia. M.B. Fernandes, A. Melão, J. Matos, H. Cadilha, S. Pyne, N.J. Pyne, J.T. Barata* - Best Oral Communication Sphingolipids in Health and Disease FEBS/SLC/iCC
Federation of European Biochemical Societies (Cascais, Portugal)
2019 “Development of IL-7R blocking antibodies to treat T-ALL”, Session on Research, Joint iBFM Resistant Disease Committee and IntReALL 2010-2020 study group Interim Meeting, Nice, France, 15-16 November. (Other speakers: Andreas Kulozik, Pablo Menendez, Pieter Van Vlierberghe) Joint iBFM Resistant Disease Committee and IntReALL 2010-2020 study group Interim Meeting
(Nice, France)
2019 “IL-7R and PTEN in T-ALL”, European School of Haematology INTERNATIONAL CONFERENCE ON ACUTE LYMPHOBLASTIC LEUKAEMIA, Berlin, Germany, 17-19 May. (Other speakers: Charles Mullighan, Tariq Enver, Jean-Pierre Bourquin, Hervé Dombret) European School of Haematology INTERNATIONAL CONFERENCE ON ACUTE LYMPHOBLASTIC LEUKAEMIA
(Berlin, Germany)
2019 Participation in the round table on Cuidados de Sáude – Perspectivando o Futuro [Health Care – Picturing the Future], discussing the talks of Faustino Ferreira, Adalberto Campos Fernandes, Carlos Alberto Ferreira, Manuel Sobrinho Simões, José Santos-Victor, Henrique Bicha Castelo, Catarina Oliveira and Alexandre Castro Caldas, 25th Anniversary of Hospital SAMS, Lisbon, 9 November. Round table on Cuidados de Sáude – Perspectivando o Futuro [Health Care – Picturing the Future]
(Lisbon, Portugal)
2019 “Acute lymphoblastic leukemia: can basic science contribute to novel therapeutic solutions?” ASPIC CONFERENCE - Research on Pediatric Cancer: Where are we? Where are we going?, Calouste Gulbenkian Foundation, Lisbon, Portugal, 8 November. ASPIC CONFERENCE - Research on Pediatric Cancer: Where are we? Where are we going?
(Lisbon, Portugal)
2019 Plenary Talk “IL-7 and IL-7R: signals impacting on leukemia development”, SINAL 2019 - Xth meeting on Signal Transduction, Olhão, Portugal, 18-19 October. SINAL 2019 - Xth meeting on Signal Transduction
(Olhão, Portugal)
2019 Participation in the round table “PhD? Check!; Post-Doc? Check! What's next? - Canonical and Non-canonical Research”, iMM PostDoc Day - Instituto de Medicina Molecular João Lobo Antunes. 25 February. iMM PostDoc Day
Instituto de Medicina Molecular João Lobo Antunes (Lisbon, Portugal)
2019 “Signals from the outside, signals from within: searching for new biological insights with therapeutic potential in T-cell leukemia”, CRIG - Center for Medical Genetics, University of Ghent, Belgium, 18 September. (Host: Prof. Frank Speleman)
CRIG - Center for Medical Genetics, University of Ghent, Belgium, 18 September. (Host: Prof. Frank Speleman) (Ghent, Belgium)
2019 “The ins and outs of IL-7R-mediated signaling in leukemia”, CIC - Centro de Investigación del Cáncer, University of Salamanca, Spain, 21 March. (Host: Prof. Xosé Bustelo)
CIC - Centro de Investigación del Cáncer, University of Salamanca, Spain, 21 March. (Host: Prof. Xosé Bustelo) (Salamanca, Spain)
2019 “Cell-autonomous and extracellular signaling cues in leukemia development: new targets for therapeutic intervention”, Jinan University, Guangzhou, Guangdong, China, 12 January. (Host: Prof. Zhinan Yin)
Jinan University, Guangzhou, Guangdong, China, 12 January. (Host: Prof. Zhinan Yin) (Guangzhou, China)
2019 “Interleukin 7 and its receptor in leukemia: from basic biology to possible new therapeutics”, CICECO, Universidade de Aveiro, 16 October (Hosts: Drs. Ana C. Sousa and Mara Freire).
CICECO, Universidade de Aveiro, 16 October (Hosts: Drs. Ana C. Sousa and Mara Freire). (Aveiro, Portugal)
2019 Sphingosine Kinases are key effectors of IL-7R-mediated signaling, viability, growth and proliferation in T-cell Acute Lymphoblastic Leukemia. M.B. Fernandes, A. Melão, J. Matos, H. Cadilha, S. Pyne, N.J. Pyne, J.T. Barata* (Poster presentation) Xth SINAL meeting on Signal Transduction
(Olhão, Portugal)
2019 Overexpression of wild type IL-7Ra promotes T-cell acute lymphoblastic leukemia/lymphoma. A. Silva, A. Almeida, M. Matos, S. Demeyer, A. Cachucho, T. Hogan, Y. Li, J. Meijerink, J. Cools, A.R. Grosso, B. Seddon* and J.T. Barata* (Poster presentation) ESID 2019 Focused Meeting - Immunodeficiencies with increased risk of cancer
(Brussels, Belgium)
2019 IL-7 either promotes or inhibits autophagy, depending on the stress context, to promote the viability of T-cell acute lymphoblastic leukemia cells. D. Ribeiro, I. Lopes, M. Abreu, C. Custódia, J.T. Barata* (Poster presentation) 6th meeting of the International Society of Cancer Metabolism (ISCaM)
(Braga, Portugal)
2019 The role of ubiquitin conjugating enzymes in brain metastases. E. Paisana, R. Cascão, C. Custódia, N. Qin, D. Picard, T. Carvalho, P. Pereira, R. Roque, J. Pimentel, M. Remke, J. Miguéns, J.T. Barata, C.C. Faria. (Poster presentation) EACR Cancer Genomics
(Cambridge, United Kingdom)
2019 Nrarp Displays Either Pro- or Anti-Tumoral Roles in T-Cell Acute Lymphoblastic Leukemia Depending on Notch and Wnt Signaling. M. Duque, I. Pinto, J. Gonçalves, P. Akkapeddi, M. Oliveira, R. Cabrita, A. Yunes, S. Durum, J.T. Barata, R. Fragoso (Poster presentation) 1st ESH International Conference on Acute Lymphoblastic Leukaemia
(Berlin, Germany)
2019 Preliminary characterization of IL-7/IL-7R phospho-signaling landscape. . Fragoso, M. Matos, A.R. Grosso, J.T. Barata* (Poster presentation) 1st ESH International Conference on Acute Lymphoblastic Leukaemia
(Berlin, Germany)
2019 CASZ1 is overexpressed in T-cell acute lymphoblastic leukemia and promotes cell transformation via PI3K-Akt-mTOR signaling. B.A. Cardoso, A. Gírio, R. Fragoso, L.R. Martins, A.S. Moreira, N.C. Correia, A. Bortolini, A.R. Grosso, S.F. de Almeida, J. Andres Yunes, F. Pflumio, J.T. Barata* (Poster presentation) 1st ESH International Conference on Acute Lymphoblastic Leukaemia
(Berlin, Germany)
2019 Exploring new facets of interleukin-7 receptor-mediated signaling in T-cell leukemia. A.S. Ramalho, J. Ferreira da Silva, F. Perez, J.T. Barata* (Poster presentation) 10th AIMS Meeting
(Lisbon, Portugal)
2019 The role of ubiquitin conjugating enzymes in brain metástases. E. Paisana, R. Cascão, C. Custódia, N. Qin, D. Picard, T. Carvalho, P. Pereira, R. Roque, J. Pimentel, M. Remke, J. Miguéns, J.T. Barata and C.C. Faria (Poster presentation) XI Congresso Nacional da Associação Portuguesa de Neuro-Oncologia [XI National Congress of the Portuguese Association of Neuro-Oncology]
(Lisbon, Portugal)
2018/12 IL-7 Activates a STAT5/PIM1 axis to Promote T-cell Acute Lymphoblastic Leukemia Proliferation and Viability in a Bcl-2-Independent Manner. D. Ribeiro, A. Melão, R. van Boxtel, C.I. Santos, A. Silva, M.C. Silva, B.A. Cardoso, P.J. Coffer, J.T. Barata* The American Society of Hematology 60th Annual Meeting.
ASH - American Society of Hematology (San Diego, United States)
2018/11 O valor prognóstico da sobre-expressão de nucleolina em neoplasias hematológicas [The prognostic value of nucleolin overexpression in hematological neoplasias]. M.I. Pereira, A.B. Sarmento-Ribeiro, L. Ribeiro, J.T. Barata, J.-N. Moreira Annual Meeting of the Portuguese Society of Hematology
SPH - Sociedade Portuguesa de Hematologia (Vilamoura, Portugal)
2018/09 A phage display-generated fully human anti-IL-7Ra antibody shows anti-tumor activity against T-cell acute lymphoblastic leukemia. P. Akkapeddi, R. Fragoso, J. Hixon, S. Ramalho, M. Oliveira, T. Carvalho, A. Gloger, M. Matasci, F. Corzana, S.K. Durum, D. Neri, G.J.L. Bernardes*, J.T. Barata* SINAL 2018 – 9th Meeting on Signal Transduction
SINAL - Signal Transduction Network (Lisboa, Portugal)
2018/09 IL-7 Activates a STAT5/PIM1 axis to Promote T-cell Acute Lymphoblastic Leukemia Proliferation and Viability in a Bcl-2-Independent Manner. D. Ribeiro, A. Melão, R. van Boxtel, C.I. Santos, A. Silva, M.C. Silva, B.A. Cardoso, P.J. Coffer, J.T. Barata* SINAL 2018 – 9th Meeting on Signal Transduction
SINAL - Signal Transduction Network (Li, Portugal)
2018/06 Mutant IL-7 receptor cooperates with Myc and activated Notch to accelerate T-cell leukemogenesis in zebrafish. M.L. Oliveira, E.G. Garcia, D.M. Langenau*, J.T. Barata* 13th International Zebrafish Conference
IZFS - International Zebrafish Society (Madison, Wisconsin, United States)
2018/05 CASZ1 is overexpressed in T-cell acute lymphoblastic leukemia and promotes cell transformation and tumor growth via PI3K-mTOR. B.A. Cardoso, A. Gírio, R.Fragoso, L.R. Martins, A.S. Moreira, N.C. Correia, A. Bortolini, A.R. Grosso, S.F. Almeida, J.A. Yunes, F. Pflumio, J.T. Barata* - Best Oral Communication 3rd ASPIC International Congress
ASPIC - Associação Portuguesa de Investigação em Cancro (Lisboa, Portugal)
2018/05 Patient-derived xenograft models of brain metastases for translational medicine. C.C. Faria, C. Custódia, E. Paisana, R. Cascão, J.T. Barata * 3rd ASPIC International Congress
ASPIC - Associação Portuguesa de Investigação em Cancro (Lisbon, Portugal)
2018 “IL-7R and leukemia”, Symposia on Tumour Biology: from basic biology to disease, Lisboa, 5-6 December. (Other speakers: Rong Li, Eric Sahai, Kari Alitalo, Giorgio Scita) Symposia on Tumour Biology: from basic biology to disease,
(Lisb, Portugal)
2018 “IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update”, Advances in Biological Regulation – 59th International Symposium on “Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues”, University of Bologna, Italy, 1-2 October. (Other speakers: Alex Toker, John York, Vytas Bankaitis, Adam Mead, Carlo Croce) Advances in Biological Regulation – 59th International Symposium on “Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues
(Bologna, Italy)
2018 “João Barata’s Lab - Signaling in Cancer”, iMM Summit - Building partnerships between research and industry, 16-17 November. iMM Summit - Building partnerships between research and industry
Instituto de Medicina Molecular João Lobo Antunes (Lisbon, Portugal)
2018 “Good gone bad: IL-7 and IL-7R in leukemia” (Plenary talk), IV Postgrad Symposium in Biomedicine, IBIMED, University of Aveiro, 5 July. V Postgrad Symposium in Biomedicine, IBIMED
Universidade de Aveiro (Aveiro, Portugal)
2018 “Explorar os mecanismos básicos da leucemia para revelar novas estratégias de tratamento [Exploring the basic mechanisms of leukemia to reveal new treatment strategies]”, IX Jornadas Nacionais de Ciências Biomédicas [IX National Meeting of Biomedical Sciences], University of Algarve, Faro, 20 April. IX Jornadas Nacionais de Ciências Biomédicas [IX National Meeting of Biomedical Sciences]
Universidade do Algarve (Faro, Portugal)
2018 “The consequences of not being good whiskey: IL-7 in leukemogenesis”, Institut Pasteur, Paris, France, 11 Setembro. (Host: Dr. Paulo Vieira)
Institut Pasteur, Paris, France, 11 Setembro. (Host: Dr. Paulo Vieira) (Paris, France)
2018 “Good gone rogue: IL-7 and IL-7R in lymphoid leukemia”, Institut Curie, Paris, France, 10 September. (Host: Dr. François Radvanyi)
Institut Curie, Paris, France, 10 September. (Host: Dr. François Radvanyi) (Pais, France)
2018 “The problem of not being good whiskey… IL-7 and IL-7R in T-cell leukemia”, Instituto Gulbenkian de Ciência, Oeiras, 16 November (Host: Dr. Vera Martins).
Instituto Gulbenkian de Ciência, Oeiras, 16 November (Host: Dr. Vera Martins). (Oeiras, Portugal)
2018 “IL-7R signaling and other stories: searching for molecular targets in T cell leukemia”, Fairjourney Biologics, Porto, 7 September (Host: Dr. Maria Pajuelo).
Fairjourney Biologics, Porto, 7 September (Host: Dr. Maria Pajuelo). (Porto, Portugal)
2018 “Gone rogue: IL-7 and IL-7R in leukemia”, CMBR Distinguished Seminars, Center for Biomedical Research, Universidade do Algarve, Faro, 3 July (Host: Prof. Ana-Teresa Maia).
CMBR Distinguished Seminars, Center for Biomedical Research, Universidade do Algarve, Faro, 3 July (Host: Prof. Ana-Teresa Maia). (Faro, Portugal)
2018 “O papel da interleucina 7 e seu receptor em leucemia linfoblástica aguda: da ciência básica a possíveis terapias? [The role of interleukin 7 and its receptor in lymphoid leukemia: from basic science to possible therapies?]”, CAML (Centro Académico de Medicina de Lisboa) Sessions - What’s new in CAML, Faculdade de Medicina, Universidade de Lisboa, 22 Março (Host: Prof. João Lacerda).
CAML (Centro Académico de Medicina de Lisboa) Sessions - What’s new in CAML, Faculdade de Medicina, Universidade de Lisboa, 22 Março (Host: Prof. João Lacerda). (Lisbon, Portugal)
2018 “Cancer Biology - What have we learned?”, Novartis Course “ARE WE CLOSER TO CURE LEUKEMIA? FROM TARGET TO PERSONALIZED THERAPY.” Annual Meeting of the Portuguese Society of Hematology, Vilamoura, Portugal, 15-17 November. Annual Meeting of the Portuguese Society of Hematology
(Vilamoura, Portugal)
2018 “Signaling in Cancer”, Advanced Course on “Fundamentals of Genetics, Development and Neoplasia”, International Postgraduate Programme, Instituto de Investigação em Ciências da Vida e Saúde (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, 23 October. International Postgraduate Programme, Instituto de Investigação em Ciências da Vida e Saúde (ICVS)
(Braga, Portugal)
2018 Does mutant interleukin-7 receptor-mediated signalling occur from intracellular compartments? A.S. Ramalho, J. Ferreira da Silva, F. Perez, J.T. Barata* (Poster presentation) Symposia on Tumour Biology: from basic biology to disease
(lisbon, Portugal)
2018 CASZ1 is overexpressed in T-cell acute lymphoblastic leukemia and promotes cell transformation and tumor growth via PI3K-mTOR signaling. B.A. Cardoso, A. Gírio, R.Fragoso, L.R. Martins, A.S. Moreira, N.C. Correia, A. Bortolini, A.R. Grosso, S.F. Almeida, J.A. Yunes, F. Pflumio, J.T. Barata* (Poster presentation) Symposia on Tumour Biology: from basic biology to disease
(Lisbon, Portugal)
2018 A phage display-generated fully human anti-IL-7Ra antibody shows anti-tumor activity against T-cell acute lymphoblastic leukemia. P. Akkapeddi, R. Fragoso, J. Hixon, S. Ramalho, M. Oliveira, T. Carvalho, A. Gloger, M. Matasci, F. Corzana, S.K. Durum, D. Neri, G.J.L. Bernardes*, J.T. Barata* (Poster presentation) The American Society of Hematology 60th Annual Meeting
(San Diego, United States)
2018 IL-7 either promotes or inhibits autophagy, depending on the stress context, to promote the viability of T-cell acute lymphoblastic leukemia cells. D. Ribeiro, I. Lopes, M. Abreu, C. Custódia, J.T. Barata* (Poster presentation) The American Society of Hematology 60th Annual Meeting
(San Diego, United States)
2018 Mutant IL-7 receptor cooperates with Myc and activated Notch to accelerate T-cell leukemogenesis in zebrafish. M.L. Oliveira, E.G. Garcia, D.M. Langenau*, J.T. Barata* (Poster presentation) 3rd ASPIC International Congress
(Lisbon, Portugal)
2018 Antibody based therapy for T-cell Acute Lymphoblastic Leukemia through Targeting IL-7 receptor. P. Akkapeddi, D. Neri, G. Bernardes*, J.T. Barata* (Poster presentation) 3rd ASPIC International Congress
(Lisbon, Portugal)
2018 STAT5 is Essential for IL-7-Mediated Viability, Growth and Proliferation of Human T-Cell Acute Lymphoblastic Leukemia Cells. D. Ribeiro, A. Melão, R. van Boxtel, C.I. Santos, A. Silva, M.C. Silva, B.A. Cardoso, P.J. Coffer, J.T. Barata* (Poster presentation) 3rd ASPIC International Congress
(Lisbon, Portugal)
2018 Dual role of NRARP in Notch and Wnt signaling differentially impacts T-cell acute lymphoblastic leukemia. M. Duque, I. Pinto, J. Gonçalves, P. Akkapeddi, M.L. Oliveira, T. Carvalho, R. Cabrita, J.A. Yunes, J.T. Barata, R. Fragoso (Poster presentation) 3rd ASPIC International Congress
(Lisbon, Portugal)
2017/06 Involvement of CASZ1 in T-cell acute lymphoblastic leukemia. R. Fragoso, A. Gírio, B.A. Cardoso, L.R. Martins, A. Bortolini, N.C. Correia, A.R. Grosso, J.A. Yunes, F. Pflumio, J.T. Barata* Young EHA - Research Meeting on Molecular Aspects of Hematological Disorders
EHA - European Hematology Association (Madrid, Spain)
2017/06 CASZ1 is overexpressed in T-cell acute lymphoblastic leukemia and promotes cell transformation via MEK/Erk and PI3K signaling. A. Gírio, B.A. Cardoso, R. Fragoso, L.R. Martins, N.C. Correia, A.R. Grosso, A. Bortolini, J.A. Yunes, F. Pflumio, J.T. Barata* SINAL 2017 – 8th Meeting on Signal Transduction
SINAL - Signal Transduction Network (Lisb, Portugal)
2017/06 Regulation of NOTCH and WNT signaling pathways by NRARP in T-cell acute lymphoblastic leukemia. I. Pinto, M. Duque, M. Oliveira, R. Cabrita, J.T. Barata, R. Fragoso SINAL 2017 – 8th Meeting on Signal Transduction
SINAL - Signal Transduction Network (Li, Portugal)
2017 “Too much of a good thing: IL-7R-mediated signaling and T-cell leukemia”, GABBA Symposium: T lymphocyte activation, i3S, Porto, Portugal, 31 March. (Other speakers: Victor Tybulewicz, Antonella Viola, Gillian Griffiths, Gottfried Baier) GABBA Symposium: T lymphocyte activation
Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2017 “Twists and turns of IL-7/IL-7R-mediated signaling in T-ALL”, T-ALL Workshop, Leuven, Belgium, 17-19 March. (Other speakers: Charles Mullighan, Tom Look, Adolfo Ferrando, Jon Aster, Michelle Kelliher, Cristina Lo Celso, Trang Hoang, David Langenau) T-ALL Workshop,
(Leuven, Belgium)
2017 “Transdução de sinal em leucemias da linhagem linfoide: entender a biologia básica para identificar novos alvos terapêuticos [Signal transduction in lymphoid leukemias: understanding the basic biology to identify new therapeutic targets]”, Hematology Research Meeting - Translational Research in Hematology by Portuguese Labs, CIM – FMUP, Porto, 8 April. Hematology Research Meeting - Translational Research in Hematology by Portuguese Labs
Universidade do Porto Faculdade de Medicina (Porto, Portugal)
2017 “STAT5: a JAK of all trades in IL-7-mediated T-ALL cell survival, growth and proliferation?”, Hematology Mini-Symposium, KU Leuven, Belgium, 27 November. (Host: Prof. Kim de Keersmaecker)
Hematology Mini-Symposium, KU Leuven, Belgium, 27 November. (Host: Prof. Kim de Keersmaecker) (Leuven, Belgium)
2017 “Overview of the work at João Barata’s lab”, iMM Retreat, University of Évora, 9 May.
iMM Retreat, University of Évora, 9 May. (Évora, Portugal)
2017 “Unraveling critical pathways to lymphoid leukemia”, i3S, Porto, 21 April. (Host: Dr. Carla Oliveira)
i3S, Porto, 21 April. (Host: Dr. Carla Oliveira) (Porto, Portugal)
2017 “Diving into IL-7/IL-7R signaling in health and malignancy”, iMM ERC Symposium - ERC 10 year celebration, iMM-Lisboa, Lisbon, 16 March.
iMM ERC Symposium - ERC 10 year celebration, iMM-Lisboa, Lisbon, 16 March. (Lisbon, Portugal)
2017 “Signaling in Cancer”, Advanced Course on “Fundamentals of Genetics, Development and Neoplasia”, International Postgraduate Programme, Instituto de Investigação em Ciências da Vida e Saúde (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, 25 October. International Postgraduate Programme, Instituto de Investigação em Ciências da Vida e Saúde (ICVS)
(Braga, Portugal)
2017 “Interleukin 7-mediated signaling in T-cell leukemia”, ReTuBi Twinning network 2017 Summer School, Oceanário de Lisboa, Lisbon, Portugal, 30 May. ReTuBi Twinning network 2017 Summer School
(Lisbon, Portugal)
2017 Oncogenic IL-7 receptor cooperates with Myc and activated Notch to accelerate T-cell leukemogenesis in zebrafish. M.L. Oliveira, E.G. Garcia, D.M. Langenau, J.T. Barata* (Poster presentation) ZDM10 Conference of the Zebrafish Disease Models Society
(San Diego, United States)
2017 Scrutinizing PHF6 regulatory networks in T-ALL and normal hematopoiesis using zebrafish. S. Loontiens, K. Durinck, I. Van de Walle, F.E. Moore, S. Vanhauwaert, E. Janssens, G. Dewyn, L. Depestel, M.L. Oliveira, J.T. Barata, D.M. Langenau, P. Van Vlierberghe, T. Taghon, F. Speleman (Poster presentation) ZDM10 Conference of the Zebrafish Disease Models Society
(San Diego, United States)
2017 IL-7 Flexibly Regulates Autophagy-dependent Viability of T-cell Acute Lymphoblastic Leukemia Cells. D. Ribeiro, I. Lopes, C. Custódia, J. Silva, M. Abreu, J.T. Barata* (Poster presentation) 22nd Congress of the European Hematology Association
(Madrid, Spain)
2017 Regulation of NOTCH and WNT signaling pathways by NRARP in T-cell acute lymphoblastic leukemia. I. Pinto, M.L. Oliveira, J.T. Barata, R. Fragoso (Poster presentation) 22nd Congress of the European Hematology Association
(Madrid, Spain)
2017 STAT5 activation associates with high risk and poor prognosis in pediatric B-cell acute lymphoblastic leukemia. M.L. Oliveira, A.M. Gomes, L.R. Martins, J. Duarte, J.T. Barata* (Poster presentation) SINAL 2017 – 8th Meeting on Signal Transduction
(Lisbon, Portugal)
2017 IL-7 Flexibly Regulates Autophagy-dependent Viability of T-cell Acute Lymphoblastic Leukemia Cells. D. Ribeiro, I. Lopes, C. Custódia, J. Silva, M. Abreu, J.T. Barata* (Poster presentation) SINAL 2017 – 8th Meeting on Signal Transduction
(Lisbon, Portugal)
2017 IL-7 Flexibly Regulates Autophagy-dependent Viability of T-cell Acute Lymphoblastic Leukemia Cells. D. Ribeiro, I. Lopes, C. Custódia, J. Silva, M. Abreu, J.T. Barata* (Poster presentation) T-ALL Workshop
(Leuven, Belgium)
2017 A Dual Role of NRARP in T-cell Acute Lymphoblastic Leukemia Pathogenesis. I. Pinto, M. Lobato, J.T. Barata, R. Fragoso (Poster presentation) T-ALL Workshop
(Leuven, Belgium)
2016/10 Targeting the IL-7R Pathway in Leukemia with Jak Inhibitors and MAbs. S. Durum, J. Hixon, E. Senkevitch, S. Cramer, J.T. Barata, S. Walsh, W. Li CYTOKINES 2016 - 4th Annual Meeting of the International Cytokine and Interferon Society (ICIS)
ICIS - International Cytokine and Interferon Society (San Francisco, United States)
2016 “One of many roads to sail the sea”, 1st CEDOC PhD Retreat, CEDOC, NOVA Medical School, Lisbon, 9 September. 1st CEDOC PhD Retreat
Universidade Nova de Lisboa CEDOC CHRONIC DISEASES FCM NOVA (Lisbon, Portugal)
2016 “Exploring the twists and turns of signaling in leukemia for therapeutic purposes”, Strathclyde University, Glasgow, UK, 22 June. (Host: Prof. Nigel Pyne)
Strathclyde University, Glasgow, UK, 22 June. (Host: Prof. Nigel Pyne) (Glasgow, United Kingdom)
2016 “The twists and turns of signaling in T-cell leukemia”, CEDOC, NOVA Medical School, Lisbon, 18 May (Host: Dr. Helena Soares).
CEDOC, NOVA Medical School, Lisbon, 18 May (Host: Dr. Helena Soares). (Lisbon, Portugal)
2016 “Signaling in Cancer”, Advanced Course on “Fundamentals of Genetics, Development and Neoplasia”, International Postgraduate Programme, Instituto de Investigação em Ciências da Vida e Saúde (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, 27 October. International Postgraduate Programme, Instituto de Investigação em Ciências da Vida e Saúde (ICVS)
(Braga, Portugal)
2016 “Vias de sinalização em cancro e terapia dirigida [Signal transduction and targeted therapy]”, Curricular unit “Da clínica à biologia molecular [From the clinics to molecular biology]”, Integrated Masters in Medicine (6th year students), Instituto de Investigação em Ciências da Vida e Saúde (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, 27 October. Integrated Masters in Medicine (6th year students), Instituto de Investigação em Ciências da Vida e Saúde (ICVS)
(Braga, Portugal)
2016 Generation and characterization of a fully human antibody against the interleukin-7 receptor, a potential target for T-ALL. . Akkapeddi, J.T. Barata*, G. Bernardes*, D. Neri* (Poster presentation) 2nd ASPIC International Congress
(Porto, Portugal)
2016 STAT5 activation associates with high risk and poor prognosis in pediatric B-cell acute lymphoblastic leukemia. M. Oliveira, A.M. Gomes, L.R. Martins, J. Duarte, J.T. Barata* (Poster presentation) 2nd ASPIC International Congress
(Lisbon, Portugal)
2016 Do IL-7Ra gain -of-function mutants signal from intracellular compartments? Implications for acute lymphoblastic leukemia. J. Ferreira da Silva, J.T. Barata* (Poster presentation) 2nd ASPIC International Congress
(Porto, Portugal)
2016 Tal1-regulated MIR-146b has a tumor suppressor role in T-cell acute lymphoblastic leukemia. R. Fragoso, N.C. Correia, T. Carvalho, F.J. Enguita, J.T. Barata* (Poster presentation) 2nd ASPIC International Congress
(porto, Portugal)
2016 A dual role of NRARP in T-cell acute lymphoblastic leukemia pathogenesis. I. Pinto, M. Lobato, R. Cabrita, J.T. Barata, R. Fragoso (Poster presentation) 2nd ASPIC International Congress
(Porto, Portugal)
2015 “CHK1 and replicative stress in T-cell leukemia: how a potential tumor suppressor acts as an oncogene”, Advances in Biological Regulation – 56th International Symposium on “Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues”, University of Bologna, Italy, 5-6 October. (Other speakers: Len Stephens, Maria A. de Matteis, Adolfo Saiardi, Sarah Spiegel, Pann-Gill Suh) Advances in Biological Regulation – 56th International Symposium on “Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues”
(Bologna, Italy)
2015 “Signaling, Oncogenes and T-cell Leukemia”, Meeting “Cancer Epigenetics and Metabolism: Connecting the Dots”, Biocant Park, Cantanhede, Portugal, 2-3 February. (Other speakers: Paolo Sassone-Corsi, Gabriella Ficz, Maarten Van Lohuizen) Meeting “Cancer Epigenetics and Metabolism: Connecting the Dots”
(Cantanhede, Portugal)
2015 “A importância da via PI3Kd na Leucemia Linfocítica Crónica [The importance of PI3Kd in Chronic Lymphocytic Leukemia]”, Gilead Satellite Symposium Inovação em Hemato-Oncologia: Leucemia Linfocítica Crónica e PI3Kd, 8th APFH Week - VIII National Congress of the Portuguese Association of Clinical Pharmacists, Cascais, Portugal, 18-21 November. Gilead Satellite Symposium Inovação em Hemato-Oncologia: Leucemia Linfocítica Crónica e PI3Kd, 8th APFH Week - VIII National Congress of the Portuguese Association of Clinical Pharmacists
(Cascais, Portugal)
2015 “Transdução de sinal e terapias dirigidas: Em busca de novos alvos moleculares para o tratamento de leucemias da linhagem linfoide [Signal transduction and targeted therapies: in search of novel molecular targets for the treatment of lymphoid leukemias]”, Annual Meeting of the Portuguese Society of Hematology (SPH), Figueira da Foz, Portugal, 12-14 November. Annual Meeting of the Portuguese Society of Hematology (SPH)
(Figueira da Foz, Portugal)
2015 “Mr Hyde exposed: interleukin 7 signaling in T-cell acute lymphoblastic leukemia”, Institute of Immunity and Transplantation, UCL, London, UK, 2 July. (Host: Dr. Ben Seddon)
Institute of Immunity and Transplantation, UCL, London, UK, 2 July. (Host: Dr. Ben Seddon) (London, United Kingdom)
2015 “From the outside, from within: exploring the signals essential for leukemia development”, Champalimaud Center For the Unknown, Lisbon, 22 October (Host: Prof. António Parreira).
Champalimaud Center For the Unknown, Lisbon, 22 October (Host: Prof. António Parreira). (Lisbon, Portugal)
2015 “Aberrant signaling in leukemia: Understanding basic biology to devise new therapies?”, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, 19 March (Host: Dr. Branca Cavaco).
Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, 19 March (Host: Dr. Branca Cavaco). (Lisbon, Portugal)
2015 “Signaling in Cancer”, Advanced Course on “Fundamentals of Genetics, Development and Neoplasia”, International Postgraduate Programme, Instituto de Investigação em Ciências da Vida e Saúde (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, 13 October. International Postgraduate Programme, Instituto de Investigação em Ciências da Vida e Saúde (ICVS)
(Braga, Portugal)
2015 “Imunobiologia em Oncologia: Novos Alvos Terapêuticos / Terapias de Transdução de Sinal [Immunobiology in oncology: new therapeutic targets/ Signaling Therapies]”, 2º Curso APFH - Biofármacos e Imunoterapia [2nd Course from the Portuguese Association of Hospital Pharmacists - Biopharmaceuticals and Immunotherapy], Coimbra, Portugal, 26 September. 2º Curso APFH - Biofármacos e Imunoterapia [2nd Course from the Portuguese Association of Hospital Pharmacists - Biopharmaceuticals and Immunotherapy]
(Coimbra, Portugal)
2015 “Autophagy in Disease I - IL-7 and Leukemia”, Advanced Course on “Autophagy in Health and Disease, conceptual and methodological advances”, School of Health Sciences, University of Minho, Braga, Portugal, 8 April. Advanced Course on “Autophagy in Health and Disease, conceptual and methodological advances”
(Braga, Portugal)
2015 The JAK Inhibitor Ruxolitinib Is Effective in Treating T Cell Acute Lymphoblastic Leukemia with Gain of Function Mutations in IL-7R Alpha. E. Senkevitch, J. Hixon, C. Andrews, J.T. Barata, W. Li, S. Durum (Poster presentation) The American Society of Hematology 57th Annual Meeting
(Orlando, United States)
2015 Sphingosine kinases are required for IL-7-mediated signaling in T-cell acute lymphoblastic leukemia. A. Melão, J. Matos, H. Cadilha, J.T. Barata* (Poster presentation) EHA 2015 - 20th Congress of the European Hematology Association
(Vienna, Austria)
2015 IL-7 activates the JAK/STAT5/PIM1 kinase axis thereby mediating viability and growth of T-cell acute lymphoblastic leukemia cells. D. Ribeiro, A. Melão, R. van Boxtel, C.I. Santos, M.C. Silva, A. Silva, B.A. Cardoso, L.F. Moita, P.J. Coffer and J.T. Barata* (Poster presentation) EHA 2015 - 20th Congress of the European Hematology Association
(Vienna, Austria)
2015 MiR-146B in T-cell acute lymphoblastic leukemia: a possible tumor supressor role. N.C. Correia, R. Fragoso, V. Póvoa, F.J. Enguita, J.T. Barata* (Poster presentation) EHA 2015 - 20th Congress of the European Hematology Association
(Vienna, Austria)
2015 The role of NRARP in T-cell acute lymphoblastic leukemia pathogenesis and chemotherapy sensitivity. M. Lobato, R. Cabrita, J.T. Barata, R. Fragoso (e-poster presentation) EHA 2015 - 20th Congress of the European Hematology Association
(Vienna, Austria)
2015 Bone Marrow Stroma Mediated Protection of MPN cells from Ruxolitinib- and Vorinostat-Induced Apoptosis Requires MAPK-JNK and PI3K-Akt/PKB signaling pathway activation. B.A. Cardoso, H. Belo, J.T. Barata, A. Almeida (e-poster presentation) EHA 2015 - 20th Congress of the European Hematology Association, Vienna, Austria
(Vienna, Austria)
2014/11 Flexible IL-7-mediated regulation of autophagy promotes T-cell acute lymphoblastic leukemia cell viability. D. Ribeiro, I. Lopes, M. Abreu, J.T. Barata* 1st ASPIC International Congress
ASPIC - Associação Portuguesa de Investigação em Cancro (Li, Portugal)
2014/11 A medula óssea protege células de neoplasias crónicas BCR-ABL-negativas dos efeitos citotóxicos induzidos por ruxolitinib e vorinostat [The bone marrow protects cells from chronic BCR-ABL-negative myeloproliferative neoplasias from the cytotoxic effects of Ruxolitinib and Vorinostat]. B.A. Cardoso, H. Belo, J.T. Barata, A.M. Almeida. Annual Meeting of the Portuguese Society of Hematology
SPH - Sociedade Portuguesa de Hematologia (Évora, Portugal)
2014/09 Sphingosine Kinase Modulates IL-7-Mediated Signaling in T-cell Acute Lymphoblastic Leukemia. J. Matos, A. Melão, J.T. Barata* Symposium “Sphingolipids in Health and Disease”
(Porto, Portugal)
2014/05 CK2-mediated signaling as a novel therapeutic target in chronic lymphocytic leukemia. L.R. Martins, P. Lúcio, M.C. Silva, P. Gameiro, M.G. Silva, J.T. Barata*. SINAL 2010 – 4th National Meeting on Signal Transduction
SINAL - Signal Transdcution Network (Faro, Portugal)
2014 “T-cell development gone wrong: cell autonomous and microenvironmental signals promoting leukemia”, SPI workshop HEMATOPOIESIS: FROM BENCH TO BEDSIDE, University of Minho, Braga, Portugal, 11 April. SPI workshop HEMATOPOIESIS: FROM BENCH TO BEDSIDE
Universidade do Minho (Braga, Portugal)
2014 “Na fronteira entre a Imunologia e a Oncologia: citocinas e leukemia [At the frontier between Immunology and Oncology: cytokines and leukemia]”, V MedUBI Congress, University of Beira Interior, Covilhã, Portugal, 9-10 January. V MedUBI Congress
Universidade da Beira Interior (Covilhã, Portugal)
2014 “Mr Hyde exposed: interleukin 7 signaling in T-cell leukemia”, Instituto Gulbenkian de Ciência, Oeiras, Portugal, 21 November (Host: Prof. Luís Moita).
Instituto Gulbenkian de Ciência, Oeiras, Portugal, 21 November (Host: Prof. Luís Moita). (Oeiras, Portugal)
2014 “Em busca de novos alvos moleculares para o tratamento de leukemia [Searching for new molecular targets for the treatment of leukemia]”, Clinical Sessions of the Faculty of Medicine of the University of Lisbon and Hospital de Santa Maria, Lisboa, Portugal, 6 November (Host: Prof. Maria Carmo-Fonseca).
Clinical Sessions of the Faculty of Medicine of the University of Lisbon and Hospital de Santa Maria, Lisboa, Portugal, 6 November (Host: Prof. Maria Carmo-Fonseca). (Lisbon, Portugal)
2014 “Aberrant signaling in leukemia: Understanding basic biology to devise new therapies?”, Neurosurgery Department of Hospital de Santa Maria, Lisboa, Portugal, 5 November (Host: Dr. Cláudia Faria).
Neurosurgery Department of Hospital de Santa Maria, Lisboa, Portugal, 5 November (Host: Dr. Cláudia Faria). (Lisbon, Portugal)
2014 “Ciclo celular e pontos de controlo - I: G1/S [Cell cycle & checkpoints – I (G1/S)]”, Advanced Course on “Oncologia Molecular: Biologia do Cancro e Terapias Emergentes [Molecular Oncology: Biology of Cancer and Emerging Therapies]”, IPOFG, Coimbra, Portugal, 24 October. Advanced Course on “Oncologia Molecular: Biologia do Cancro e Terapias Emergentes [Molecular Oncology: Biology of Cancer and Emerging Therapies]
(Coimbra, Portugal)
2014 Bone Marrow Stroma Protects BCR-ABL-Negative Myeloproliferative Neoplasms from Ruxolitinib- and Vorinostat-Induced Apoptosis. B.A. Cardoso, H. Belo, A.I. Oliveira, O. Pereira., J.T. Barata, A. Almeida (Poster presentation) The American Society of Hematology 56th Annual Meeting
(San Francisco, United States)
2014 Sphingosine Kinase is Required for IL-7-Mediated Signaling in T-cell Acute Lymphoblastic Leukemia. A. Melão*, J. Matos*, J.T. Barata* (Poster presentation) 1st ASPIC International Congress, Lisboa
(Lisbo, Portugal)
2014 LTßR in microenvironmental cells modulates surface lymphotoxin expression on leukemic T cells and promotes leukemogenesis. M.T. Fernandes, M.N. Ghezzo, V. Póvoa, A.R. Ribeiro, E. Dejardin, N.L. Alves, J. Ghysdael, J.T. Barata, N.R. dos Santos. (Poster presentation) 1st ASPIC International Congress
(Lisbon, Portugal)
2014 Prognostic significance of PI3K/Akt/mTOR pathway using phosphoflow in pediatric acute lymphoblastic leukemia–preliminary results. M.L. Oliveira, A.M. Gomes, L.R. Martins, J. Duarte, J.T. Barata* (Poster presentation) 1st ASPIC International Congress
(Lisbon, Portugal)
2014 Bone Marrow protects BCR-ABL-Negative Myeloproliferative Neoplasms from Ruxolitinib- and Vorinostat-Induced Apoptosis. B. A. Cardoso, H. Belo, J.T. Barata, A.M. Almeida (Poster presentation) 1st ASPIC International Congress
(Lisbon, Portugal)
2014 Evaluation of tumor cells’ biomechanical properties for assessing the chemotherapy efficacy of anticancer peptides. D. Gaspar, J.M. Freire, T.R. Pacheco, J.T. Barata, M.A.R.B. Castanho (Poster presentation) 1st ASPIC International Congress
(Lisbon, Portugal)
2014 Sphingosine Kinase-1 Modulates IL-7-Mediated Signaling in T-cell Acute Lymphoblastic Leukemia. J. Matos, A. Melão, J.T. Barata* (Poster presentation) SPI workshop HEMATOPOIESIS: FROM BENCH TO BEDSIDE
(Braga, Portugal)
2013/12 CHK1 is essential for the growth and survival of T-cell acute lymphoblastic leukemia. L.M. Sarmento, V. Povoa, R. Nascimento, G. Real, C. Moita, I. Antunes, L. Martins, P.M. Alves, M. Parkhouse, L. Moita, J. Meijerink, J.T. Barata* SINAL 2013 – 7th National Meeting on Cell Signalling,
SINAL - Signal Transduction Network (Aveiro, Portugal)
2013/12 Lymphotoxin-beta Receptor Signalling in Microenvironmental Cells Supports T-Cell Leukemogenesis. M.T. Fernandes, M.N. Ghezzo, V. Póvoa, A.R. Ribeiro, N.L. Alves, J.T. Barata, N.R. dos Santos. SINAL 2013 – 7th National Meeting on Cell Signalling,
SINAL - Signal Transduction Network (Aveiro, Portugal)
2013/10 PHARMACOLOGIC INTERVENTION OF CASEIN KINASE 2 (CK2)-MEDIATED PRO-SURVIVAL AND PROLIFERATIVE SIGNALING ON T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL). Y. Perera, A. Melao, J. Miranda, S.E. Perea, J.T. Barata* Meeting of the Latin-American Association of Pharmacology, Asociación Latinoamericana de Farmacología
(Havana, Cuba)
2013 “IL-7 and T-cell Leukemia: How Interleukins can Shape Cancer Behaviour”, 3rd Global Cancer Genomics Consortium Symposium, Lisbon, Portugal, 18-20 August. (Other speakers: Clifford Hudis, Carlos Caldas, Rakesh Kumar, Maria Carmo-Fonseca, Bruno Silva-Santos) 3rd Global Cancer Genomics Consortium Symposium
(Lisbon, Portugal)
2013 “Too much of a good thing: IL-7 and IL-7R in T-cell leukemia”, 3rd International Symposium on Translational Oncology, Barretos, SP, Brazil, 29-30 August. (Other speakers: Chris Meijer, Eduardo Franco) 3rd International Symposium on Translational Oncology
(Barretos, Brazil)
2013 “The role of IL7R in childhood T-cell acute lymphoblastic leukemia”, European Human Genetics Conference 2013, Paris, France, 8-11 June. (Other speakers: Ian Tomlinson, Lorraine O’Driscoll, Alain Fischer, Jean-Laurent Casanova) European Human Genetics Conference
(Paris, France)
2013 “Signals from the outside, signals from within: IL-7 and IL-7R in acute T-cell leukemia”, 8th Annual Helsinki Biomedical Graduate Program Symposium, Biomedicum Helsinki, Finland, 16-17 May. (Other speakers: Johanna Ivaska, Peter Krammer, Valerie Weaver, Raphael Kopan) 8th Annual Helsinki Biomedical Graduate Program Symposium
(Helsinki, Finland)
2013 IL-7 and IL-7R-mediated signaling in T-ALL”, Second ESH-EHA Scientific Workshop on T-cell Acute Lymphoblastic Leukemia, Lisbon, Portugal, 22-24 March. (Other speakers: Charles Mullighan, Jacques van Dongen, Ianis Aifantis, Tom Look, Jan Cools, Jon Aster) Second ESH-EHA Scientific Workshop on T-cell Acute Lymphoblastic Leukemia
(Lisbon, Portugal)
2013 “Good things gone bad: IL-7 and IL-7R in T-cell leukemia”, XXXIX Annual Meeting of The Portuguese Society of Immunology, Coimbra, Portugal, 13-15 November. XXXIX Annual Meeting of The Portuguese Society of Immunology
(Coimbra, Portugal)
2013 “O lado obscuro da lua: IL-7 e IL-7R em leucemia de células T [The dark side of the moon: IL-7 and IL-7R in T-cell leukemia]”, IV Science and Medicine Meeting, University of Minho, Braga, Portugal, 20 April. IV Science and Medicine Meeting
Universidade do Minho (Braga, Portugal)
2013 “Signaling in Cancer and Leukemia”, Masters in Biomedical Sciences, University of Algarve, Faro, Portugal, 24 April. Masters in Biomedical Sciences
(Faro, Portugal)
2013 “Signaling in Cancer”, Advanced Course on “Fundamentals of Genetics, Development and Neoplasia”, 5th Edition, International Postgraduate Programme, Instituto de Investigação em Ciências da Vida e Saúde (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, 15 October. Advanced Course on “Fundamentals of Genetics, Development and Neoplasia”, 5th Edition, International Postgraduate Programme, Instituto de Investigação em Ciências da Vida e Saúde (ICVS)
(Braga, Portugal)
2013 “Basic Concepts on Signaling in Cancer”, Advanced Course on Oncobiology, BEB PhD Program of the Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 26 February. Advanced Course on Oncobiology, BEB PhD Program of the Center for Neuroscience and Cell Biology (CNC)
(Coimbra, Portugal)
2013 “Signaling in Cancer”, Advanced Course on “Fundamentals of Genetics, Development and Neoplasia”, 4th Edition, International Postgraduate Programme, Instituto de Investigação em Ciências da Vida e Saúde (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, 21 January. Advanced Course on “Fundamentals of Genetics, Development and Neoplasia”, 4th Edition, International Postgraduate Programme, Instituto de Investigação em Ciências da Vida e Saúde (ICVS)
(Braga, Portugal)
2013 CK2 Activity Regulates IL-7 Pro-Oncogenic Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia. A. Melão, A. Gírio, J.T. Barata* (Poster presentation) 3rd Global Cancer Genomics Consortium Symposium
(Lisbo, Portugal)
2013 CHK1 is essential for the growth and survival of T-cell acute lymphoblastic leukemia cells. L.M. Sarmento, V. Póvoa, R. Nascimento, G. Real, I. Antunes, L.R. Martins, J. Meijerink, J.T. Barata* (Poster presentation) 3rd Global Cancer Genomics Consortium Symposium
(Lisbon, Portugal)
2013 IL-7 Activates the JAK/STAT5/PIM1 Kinase Axis Thereby Mediating Viability and Growth of T-Cell Acute Lymphoblastic Leukemia Cells.D. Ribeiro, A. Melão, R. van Boxtel, C.I. Santos, M.C. Silva, A. Silva, B.A. Cardoso, L.F. Moita, P.J. Coffer, J.T. Barata* (Poster presentation) 3rd Global Cancer Genomics Consortium Symposium
(Lisbon, Portugal)
2013 Anticancer activity and selectivity of the human neutrophil peptide-1 towards solid and hematological tumor cells. D. Gaspar, T.R.D. Pacheco, J.T. Barata, M.A.R.B. Castanho (Poster presentation) EMBO Young Scientists’s Forum on Life Sciences
(Lisbon, Portugal)
2013 Novel TAL1 targets beyond protein coding genes: identification of TAL1-regulated microRNA genes in T-cell acute lymphoblastic leukemia. N.C. Correia, F.J. Enguita, F. Speleman, J.T. Barata* (Poster presentation) RNA 2013 – The 18th Annual Meeting of the RNA Society
(Davos, Switzerland)
2013 CK2 Basal Activity Regulates IL-7-Mediated JAK/STAT and PI3K/Akt Pathway Activation and Pro-Survival Effects in T-Cell Acute Lymphoblastic Leukemia Cells. A. Melão, A. Gírio, J.T. Barata* (Poster presentation) Second ESH-EHA Scientific Workshop on T-cell Acute Lymphoblastic Leukemia
(Lisbon, Portugal)
2013 IL-7-Mediated Viability and Growth of T-Cell Acute Lymphoblastic Leukemia Cells Relies on a JAK/STAT5/PIM1 Kinase Axis. D. Ribeiro, A. Melão, R. van Boxtel, C.I. Santos, M.C. Silva, A. Silva, B.A. Cardoso, L.F. Moita, P.J. Coffer, J.T. Barata* (Poster presentation) Second ESH-EHA Scientific Workshop on T-cell Acute Lymphoblastic Leukemia
(Lisbon, Portugal)
2013 Identification of TAL1-regulated microRNA genes in T-cell acute lymphoblastic leukemia. N.C. Correia, F. Speleman, F.J. Enguita, J.T. Barata* (Poster presentation) Second ESH-EHA Scientific Workshop on T-cell Acute Lymphoblastic Leukemia
(Lisbon, Portugal)
2012/12 The Role of IL7R in the Induction and Maintenance of T-Cell Leukemia/Lymphoma in Vivo. A. Silva, J.T. Barata*, B. Seddon*. The American Society of Hematology 54th Annual Meeting,
ASH - American Society for Hematology (Atlanta, United States)
2012/11 Targeting Chronic Lymphocytic Leukemia Cells’ Viability Using CX-4945, a Clinical-Stage CK2-Specific Inhibitor. L.R. Martins, P. Lúcio, A. Melao, B.A. Cardoso, R. Stansfield, D. Drygin, M.G. Silva, J.T. Barata* XXXVIII Annual Meeting of the Portuguese Society of Immunology
SPI - Sociedade Portuguesa de Imunologia (Porto, Portugal)
2012/11 Targeting Chronic Lymphocytic Leukemia Cell Viability Using CX-4945, A Clinical-Stage CK2-specific Inhibitor. L.R. Martins, P. Lúcio, A. Melão, B.A. Cardoso, R. Stansfield, Denis Drygin, M.G. Silva, J.T. Barata* Annual Meeting of the Portuguese Society of Hematology,
SPH - Sociedade Portuguesa de Hematologia (Porto, Portugal)
2012 “From the environment, from within: IL-7R-mediated signaling in T-cell leukemia”, One Day Symposium sponsored by EACR, Eng. António de Almeida Foundation, Porto, Portugal, 29 October. (Other speakers: Julio Celis, Carlos Caldas, Miguel Godinho Ferreira) One Day Symposium sponsored by EACR
(Porto, Portugal)
2012 “IL-7R-mediated signaling in T-cell leukemia”, Advances in Biological Regulation – 53rd International Symposium on “Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues”, University of Bologna, Italy, 17-18 September. (Other speakers: Tim Hunt, Nullin Divecha, Per-Olof Berggren, Ralph Bradshaw, Vytas Bankaitis) Advances in Biological Regulation – 53rd International Symposium on “Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues”
(Bologna, Italy)
2012 “IL-7R and PI3K/mTOR signaling in T-cell leukemia”, XXI Porto Cancer Meeting (International Conference on Metabolism and Cancer – from Etiopathogenesis to Therapy), Porto, Portugal, 19-20 April. (Other speakers: John Blenis, Luca Scorrano, Evangelos Michelakis, Jacques Pouysségur) XXI Porto Cancer Meeting (International Conference on Metabolism and Cancer – from Etiopathogenesis to Therapy)
(Porto, Portugal)
2012 “Targeting aberrant signaling in T-cell acute lymphoblastic leukemia”, International Meeting Biotecnología Habana 2012 – Medical Applications of Biotechnology, Havana International Conference Center, Havana, Cuba, 5-8 March. (Other speakers: Peter Agre, Peter Roepstorff) International Meeting Biotecnología Habana 2012 – Medical Applications of Biotechnology
(Havana, Cuba)
2012 “Genetic lesions and posttranslational alterations promoting T-cell acute lymphoblastic leukemia”, 16th Annual Meeting of the Portuguese Society of Human Genetics, Porto, Portugal, 22-24 November. 16th Annual Meeting of the Portuguese Society of Human Genetics
(Porto, Portugal)
2012 “IL-7/IL-7R signaling in T-cell leukemia: Dr Jekyll or Mr Hyde?”, Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), Direction des Sciences du Vivant - CEA, Fontenaix-au-Roses, France, 29 November. (Host: Prof. Françoise Pflumio)
Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), Direction des Sciences du Vivant - CEA, Fontenaix-au-Roses, France, 29 November. (Host: Prof. Françoise Pflumio) (Fontenaix-au-Roses, France)
2012 “The dark side of the moon: IL-7 and IL-7R signaling in T-cell leukemia”, VIB Center for the Biology of Disease, KU Leuven, Belgium, 22 October. (Host: Prof. Jan Cools)
VIB Center for the Biology of Disease, KU Leuven, Belgium, 22 October. (Host: Prof. Jan Cools) (Leuven, Belgium)
2012 “Mr Hyde revealed: IL-7/IL-7R signaling in T-cell leukemia”, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 28 February (Host: Prof. João Nuno Moreira).
Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 28 February (Host: Prof. João Nuno Moreira). (Coimbra, Portugal)
2012 “Citocinas [Cytokines]”, Workshop on “Imunoterapia do Cancro: da Investigação Básica à Aplicação Clínica [Immunotherapy of Cancer: From Basic Research to Clinical Application]”, Center for Evidence-based Medical Studies (CEMBE), Faculty of Medicine of Lisbon University, Lisbon, Portugal, 24 March. “Imunoterapia do Cancro: da Investigação Básica à Aplicação Clínica [Immunotherapy of Cancer: From Basic Research to Clinical Application]”, Center for Evidence-based Medical Studies (CEMBE)
(Lisbon, Portugal)
2012 “Basic Concepts on Signaling in Cancer”, Advanced Course on Oncobiology, BEB PhD Program of the Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal, 28 February. Advanced Course on Oncobiology, BEB PhD Program of the Center for Neuroscience and Cell Biology (CNC)
(Coimbra, Portugal)
2012 CK2 Basal Activity Regulates IL-7-Mediated JAK/STAT and PI3K/Akt Pathway Activation and Pro-Survival Effects in T-Cell Acute Lymphoblastic Leukemia Cells. A. Melão, A. Gírio, J.T. Barata* (Poster presentation) The American Society of Hematology 54th Annual Meeting
(Atlanta, United States)
2012 STAT5 Activation Is Mandatory for IL-7-Mediated Viability and Growth of T-cell Acute Lymphoblastic Leukemia Cells. D. Ribeiro, A. Silva, B.A. Cardoso, J.T. Barata* (Poster presentation) The American Society of Hematology 54th Annual Meeting
(Atlanta, United States)
2012 In Vitro and in Vivo Targeting of Chronic Lymphocytic Leukemia Using CX-4945, a Clinical-Stage CK2-Specific Inhibitor. L.R. Martins, P. Lúcio, A. Melao, B.A. Cardoso, R. Stansfield, D. Drygin, M.G. Silva, J.T. Barata* (Poster presentation) The American Society of Hematology 54th Annual Meeting
(Atlanta, United States)
2012 CK2 Activity Regulates Signaling, Survival and Proliferation Mediated by IL-7 in T-cell Acute Lymphoblastic Leukemia Cells. A. Melão, M. Spit, A. Gírio, J.T. Barata* (Poster presentation) XXXVIII Annual Meeting of the Portuguese Society of Immunology
(Porto, Portugal)
2012 STAT5 Activation Is Mandatory for IL-7-Mediated Viability and Growth of T-cell Acute Lymphoblastic Leukemia Cells. D. Ribeiro, C.I. Santos, M.C. Silva, A. Silva, B.A. Cardoso, L.F. Moita, J.T. Barata* (Poster presentation) XXXVIII Annual Meeting of the Portuguese Society of Immunology
(Porto, Portugal)
2012 Differential Regulation of Basal and IL-7-induced PI3K/Akt/mTOR and Jak/STAT5 Signaling Distinguishes Pediatric from Adult ALL. A.M. Gomes, M. Soares, P. Ribeiro, J. Caldas, A.L. Caetano, A.B. Sousa, J.F. Lacerda, J.T. Barata* (Poster presentation) XXXVIII Annual Meeting of the Portuguese Society of Immunology
(Porto, Portugal)
2012 CK2 Activity Regulates Signaling, Survival and Proliferation Mediated by IL-7 in T-Cell Acute Lymphoblastic Leukemia Cells. A. Melão, M. Spit, A. Gírio, J.T. Barata* (Poster presentation) One Day Symposium sponsored by EACR
(Porto, Portugal)
2012 STAT5 is Essential for IL-7-Mediated Viability, Cell Growth and Proliferation of Human T-Cell Acute Lymphoblastic Leukemia Cells. D. Ribeiro, C.I. Santos, M.C. Silva, A. Silva, B.A. Cardoso, L.F. Moita, J.T. Barata* (Poster presentation) One Day Symposium sponsored by EACR
(Porto, Portugal)
2012 In Vitro and in Vivo Targeting of Chronic Lymphocytic Leukemia Using CX-4945, a Clinical-Stage CK2-Specific Inhibitor. L.R. Martins, P. Lúcio, A. Melao, B.A. Cardoso, R. Stansfield, D. Drygin, M.G. Silva, J.T. Barata* (Poster presentation) One Day Symposium sponsored by EACR
(Porto, Portugal)
2012 Evidence for reciprocal regulation between TAL1 and miRNAs in T-cell acute lymphoblastic leukemia. N. Correia, M. Malumbres, F. Speleman, F. Enguita, J.T. Barata* (Poster presentation) One Day Symposium sponsored by EACR
(Porto, Portugal)
2012 Differential Regulation of Basal and IL-7-induced PI3K/Akt/mTOR and Jak/STAT5 Signaling Distinguishes Pediatric from Adult ALL. A.M. Gomes, M. Soares, P. Ribeiro, J. Caldas, A.L. Caetano, A.B. Sousa, J.F. Lacerda, J.T. Barata* (Poster presentation) One Day Symposium sponsored by EACR
(Porto, Portugal)
2012 CK2 activity is mandatory for IL-7-mediated pro-survival signaling in T-cell acute lymphoblastic leukemia cells. A. Melão, A. Gírio, M. Spit, J.T. Barata* (Poster presentation) SINAL 2012 – 6th National Meeting on Cell Signaling
(Braga, Portugal)
2012 Evidence for reciprocal regulation between TAL1 and miRNAs in T-cell acute lymphoblastic leukemia. N. Correia, M. Malumbres, F. Enguita, J.T. Barata* (Poster presentation) RNA 2012 Meeting
(Lisbon, Portugal)
2011 “Signals from the outside, signals from within: finding new molecular therapeutic targets in T-cell leukemia”, International-attended, Istanbul Technical University 5th National Molecular Biology and Genetics Student Congress, Istanbul, Turkey, 19-22 August. (Other speakers: Pam Silver, Stefan Jentsch, Oscar Fernandez-Capetillo) International-attended, Istanbul Technical University 5th National Molecular Biology and Genetics Student Congress
(Istambul, Turkey)
2011 “Transdução de sinal em leucemia: novos alvos moleculares – futuras terapias? [Signal Transduction in Leukemia: New Molecular Targets – Future Therapies?]”, Scientific Meeting “Ciência e Ensino – 100 anos da FMUL [Science and Teaching – 100 Years of FMUL]” (Celebrations of the 100th Anniversary of the Faculty of Medicine of Lisbon University), Faculty of Medicine, University of Lisbon, 6-7 May. Scientific Meeting “Ciência e Ensino – 100 anos da FMUL [Science and Teaching – 100 Years of FMUL]” (Celebrations of the 100th Anniversary of the Faculty of Medicine of Lisbon University)
Universidade de Lisboa Faculdade de Medicina (Lisbon, Portugal)
2011 “Leucemia e transdução de sinal: as células tumorais também ouvem [Leukemia and signal transduction: cancer cells can also listen]”, 1o Encontro de Biologia Molecular em Saúde [1st Meeting on Molecular Biology in Health], Escola Superior de Saúde Egas Moniz, Caparica, Portugal, 18-19 March. 1o Encontro de Biologia Molecular em Saúde [1st Meeting on Molecular Biology in Health]
Escola Superior de Saúde Egas Moniz (Caparica, Portugal)
2011 “Mr Hyde revealed: IL-7/IL-7R signaling in acute T-cell leukemia”, Department of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, UK, 20 September (Host: Dr. Nick Leslie).
Department of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, UK, 20 September (Host: Dr. Nick Leslie). (Dundee, United Kingdom)
2011 “Signal Transduction Aberrations in Cancer” and “’Novel’ Concepts in Cancer Signal Transduction”, Advanced Course on Oncobiology, BEB PhD Program of the Center for Neuroscience and Cell Biology (CNC), University of Coimbra, 21 February. Advanced Course on Oncobiology, BEB PhD Program of the Center for Neuroscience and Cell Biology (CNC)
(Coimbra, Portugal)
2011 BAFF-R and TACI expression in Common Variable Immunodeficiency – insights into receptor dynamics. R.R. Barbosa, S.L. Silva, S.P. Silva, A.C. Melo, C. Pereira-Santos, J.T. Barata, A.E. Sousa (Poster presentation) XXXVII Annual Meeting of the Portuguese Society of Immunology
(Oeiras, Portugal)
2011 STAT5 Activation is Required for IL-7-mediated Viability and Growth of Human Leukemia T-cells. D. Ribeiro, C.I. Santos, M.C. Silva, A. Silva, L. Vinagre, B.A. Cardoso, L.F. Moita, J.T. Barata* (Poster presentation) SINAL 2011 – 5th Annual Meeting on Cell Signalling
(Coimbra, Portugal)
2011 Inhibition of PI3K sensitizes T-ALL cells to chemotherapy. Targeting PI3K/mTOR Signaling in Cancer. A.B. Silveira, P. Leal, B.A. Cardoso, B. Nogueira, R.A. Yunes, S.R. Brandalise, N.I.T. Zanchin, J.T. Barata, J.A. Yunes (Poster presentation) Targeting PI3K/mTOR Signaling in Cancer AACR Special Conference
(San Francisco, United States)
2010/12 The oncogene TAL1/SCL is downregulated by Histone Deacetylase inhibitors in human T-cell leukemia. B.A. Cardoso, S. de Almeida, A. Larangeira, M. Carmo-Fonseca, J.A. Yunes, P.J. Coffer, J.T. Barata*. XVII National Congress of Biochemistry
SPB - Sociedade Portuguesa de Bioquímica (Porto, Portugal)
2010/09 CK2 as a novel therapeutic target in chronic lymphocytic leukemia. L.R. Martins, P. Lúcio, M.C. Silva, P. Gameiro, M.G. Silva, J.T. Barata* 6th International Conference on Protein Kinase CK2
(Cologne, Germany)
2010/05 CK2 is overexpressed in B-cell chronic lymphocytic leukemia cells and promotes leukemia cell viability. L.R. Martins, M.C. Silva, P. Gameiro, M.G. Silva, P. Lúcio, J.T. Barata*. - Roche Best Oral Presentation to M.C. Silva XI Technical Congress of Patho-anatomy
(Évora, Portugal)
2010 “The Impact of PTEN Regulation by CK2 on PI3K-Dependent Signaling and Leukemia Cell Survival”, Advances in Enzyme Regulation – 51st International Symposium on “Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues”, University of Bologna, Italy, 4-5 October. (Other speakers: Philip W. Majerus, Len Stephens) Advances in Enzyme Regulation – 51st International Symposium on “Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues”
(Bologna, Italy)
2010 “T-ALL signals: translating posttranslational alterations into therapy?”, European Hematology Association and European School of Haematology Joint Scientific Workshop “T-cell Acute Lymphoblastic Leukemia (T-ALL) Meets Normal T-cell Development”, Mandelieu, France, 7-9 May. (Other speakers: Harald von Boehmer, Warren Pear, Juan-Carlos Zúñiga-Pflücker, Adolfo Ferrando, Jacques Ghysdael, Hans-Guido Wendel) European Hematology Association and European School of Haematology Joint Scientific Workshop “T-cell Acute Lymphoblastic Leukemia (T-ALL) Meets Normal T-cell Development”
(Mandelieu, France)
2010 “Novel molecular therapeutic targets in leukemia”, Encontro com a Ciência e a Tecnologia em Portugal 2010, Lisbon, Portugal, 4-7 July. Encontro com a Ciência e a Tecnologia em Portugal 2010
(lisbon, Portugal)
2010 “The ins and outs of T-cell leukemia: CK2, PTEN-PI3K and IL-7”, Centro de Biomedicina Molecular e Estrutural (CBME), University of Algarve, Faro, Portugal, 10 December (Host: Dr. Nuno Rodrigues dos Santos).
Centro de Biomedicina Molecular e Estrutural (CBME), University of Algarve, Faro, Portugal, 10 December (Host: Dr. Nuno Rodrigues dos Santos). (Faro, Portugal)
2010 “The ins and outs of T-cell leukemia signaling: PTEN, PI3K/Akt and IL-7”, Instituto de Investigação em Ciências da Vida e Saúde (ICVS), University of Minho, Braga, Portugal, 13 October (Host: Prof. Fátima Baltazar).
Instituto de Investigação em Ciências da Vida e Saúde (ICVS), University of Minho, Braga, Portugal, 13 October (Host: Prof. Fátima Baltazar). (Braga, Portugal)
2010 “PTEN non-deleting posttranslational inactivation in human T-cell leukemia”, Instituto Gulbenkian de Ciência, Oeiras, Portugal, 24 September. (Host: Dr. Jocelyne Demengeot).
Instituto Gulbenkian de Ciência, Oeiras, Portugal, 24 September. (Host: Dr. Jocelyne Demengeot). (Oeiras, Portugal)
2010 “Signal Transduction in Cancer”, Masters in Biomedical Sciences, University of Algarve, Faro, Portugal, 10 December. Masters in Biomedical Sciences,
(Faro, Portugal)
2010 “Cell signaling: overview” and “Cell signaling: PI3K”, Advanced Course on “Fundamentals of Genetics, Development and Neoplasia”, International Postgraduate Programme, Instituto de Investigação em Ciências da Vida e Saúde (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, 14 October. Advanced Course on “Fundamentals of Genetics, Development and Neoplasia”, International Postgraduate Programme, Instituto de Investigação em Ciências da Vida e Saúde (ICVS)
(Braga, Portugal)
2010 “Signal Transduction Aberrations in Cancer” and “’Novel’ Concepts in Cancer Signal Transduction”, Advanced Course on Oncobiology, BEB PhD Program of the Center for Neuroscience and Cell Biology (CNC), University of Coimbra, 9 March. Advanced Course on Oncobiology, BEB PhD Program of the Center for Neuroscience and Cell Biology (CNC)
(Coimbra, Portugal)
2010 Identification of three novel TAL1 target genes with potential relevance in T-cell acute lymphoblastic leukemia. A. Gírio, N. Correia, A.R. Grosso, B.A. Cardoso, J.T. Barata* (Poster presentation) SINAL 2010 – 4th National Meeting on Signal Transduction
(Faro, Portugal)
2010 TAL1/SCL is downregulated upon histone deacetylase inhibition in human T-cell leukemia. B.A. Cardoso, S. Almeida, P.J. Coffer, J.T. Barata* (Poster presentation) SINAL 2010 – 4th National Meeting on Signal Transduction
(Faro, Portugal)
2010 Inhibition of PI3K sensitizes T-ALL cells to prednisolone and methotrexate. A.B. Silveira, B. Nogueira, B.A. Cardoso, P. Leal, R.A. Yunes, J.T. Barata, N.I.T. Zanchin, J.A. Yunes (Poster presentation) European Hematology Association and European School of Haematology Joint Scientific Workshop “T-cell Acute Lymphoblastic Leukemia (T-ALL) Meets Normal T-cell Development”
(Mandelieu, France)
2009/12 Targeting CK2 Overexpression as a Novel Therapeutic Tool in Chronic Lymphocytic Leukemia. L.R. Martins, P. Lúcio, P. Gameiro, M.G. Silva, J.T. Barata*. The American Society of Hematology 51st Annual Meeting
ASH - American Society of Hematology (New Orleans, United States)
2009/05 Crosstalk between PI3K-Akt/PKB pathway and Intracellular Reactive Oxygen Species is Essential for IL-7-mediated Viability of Leukemia T-cells. A. Silva, A. Girio, I. Cebola, C. Santos, F. Antunes, J.T. Barata*. SINAL 2009 – 3rd National Meeting on Signal Transduction
SINAL - Signal Transduction Network (Aveiro, Portugal)
2009 “Does IL-7/IL-7R-mediated signaling promote human T-cell leukemia?”, SINAL 2009 – 3rd National Meeting on Signal Transduction, University of Aveiro, Portugal, 29-30 May. SINAL 2009 – 3rd National Meeting on Signal Transduction
(Aveiro, Portugal)
2009 Plenary session: “Beyond the gene: PTEN inactivation in human T cell leukemia”, XI Meeting of Sociedade Ibérica de Citometria (Iberian Society of Cytometry), Covilhã, Portugal, 7-9 May. XI Meeting of Sociedade Ibérica de Citometria (Iberian Society of Cytometry)
(Covilhã, Portugal)
2009 “Inactivation of PTEN in primary T-cell acute leukemia: beyond the canons”, WKZ – Wilhelmina Children’s Hospital, University Medical Center, Utrecht, The Netherlands, 16 April. (Host: Prof. Paul Coffer).
WKZ – Wilhelmina Children’s Hospital, University Medical Center, Utrecht, The Netherlands, 16 April. (Host: Prof. Paul Coffer). (Utrecht, Netherlands)
2009 “PTEN inactivation in primary T-cell acute leukemia: more than the canons”, Max Delbruck Center for Molecular Medicine, Berlin, Germany, 9 February. (Hosts: Dr. Jan Schmollinger and Prof. Thomas Blankenstein).
Max Delbruck Center for Molecular Medicine, Berlin, Germany, 9 February. (Hosts: Dr. Jan Schmollinger and Prof. Thomas Blankenstein). (Berlin, Germany)
2009 “Signal Transduction Aberrations in Cancer” and “’Novel’ Concepts in Cancer Signal Transduction”, Advanced Course on Oncobiology, BEB PhD Program of the Center for Neuroscience and Cell Biology (CNC), University of Coimbra, March 17. Advanced Course on Oncobiology, BEB PhD Program of the Center for Neuroscience and Cell Biology (CNC)
(Coimbra, Portugal)
2009 IL-7 accelerates human T-cell leukemia progression in vivo. Cytokine. A. Silva, B. Seddon, J.T. Barata* (Poster presentation) Tri-Society Annual Conference, Cellular and Cytokine Interactions in Health and Disease
(Lisbon, Portugal)
2009 Molecular signatures of tumors susceptible or resistant to ¿¿ T cell-mediated cytotoxicity. D.V. Correia, T. Lança, A.R. Grosso, J.T. Barata, A.Q. Gomes, B. Silva-Santos (Poster presentation) XXXV Annual Meeting of the Portuguese Society of Immunology
(Lisbon, Portugal)
2009 HDAC inhibitors in T-ALL: is TAL1 important? B.A. Cardoso, P.J. Coffer, J.T. Barata* (Poster presentation) SINAL 2009 – 3rd National Meeting on Signal Transduction
(Aveiro, Portugal)
2009 Crosstalk between PI3K-Akt/PKB pathway and Intracellular Reactive Oxygen Species is Essential for IL-7-mediated Viability of Leukemia T-cells. A. Silva, I. Cebola, C. Santos, A. Girio, F. Antunes, J.T. Barata* (Poster presentation) Keystone Symposium on PI 3-Kinase Signaling in Disease (Z3)
(Olympic Valley, United States)
2008/11 PTEN Non-deletional Posttranslational Inactivation and PI3K/Akt Pathway Hyperactivation Sustain Primary T-Cell Acute Lymphoblastic Leukemia. A. Silva, J.A. Yunes, B.A. Cardoso, L.R. Martins, P.Y. Jotta, M. Abecasis, A.E. Nowill, N.R. Leslie, A.A. Cardoso, J.T. Barata*. I Workshop DIFHEMAT “From Lymphoid Differentiation to Cancer”
(Madrid, Spain)
2008/10 Chasing the IL-7 receptor: Regulation of interleukin 7 receptor ¿ internalization, recycling and degradation by IL-7. C.M.O. Henriques, J. Rino, R.J. Nibbs, G.J. Graham, J.T. Barata*. XXXIV Annual Meeting of the Portuguese Society of Immunology
SPI - Sociedade Portuguesa de Imunologia (Porto, Portugal)
2008/05 Regulation of IL-7Ra internalization, recycling and degradation by IL-7. C.M.O. Henriques, J. Rino, R.J. Nibbs, G.J. Graham, J.T. Barata*. SINAL 2008 – 2nd National Meeting of Signal Transduction
SINAL - Signal Transdcution Network (Porto, Portugal)
2008 “Cancro – Perspectivas futuras na terapêutica [Cancer – Future perspectives in therapeutics”, Satellite Conference “Doenças do Século XXI [XXI Century Diseases]”, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal, 30 October.
Universidade de Lisboa Faculdade de Farmácia (Lis, Portugal)
2008 “Biologia do Cancro – PTEN e as mil e uma maneiras de inactivar um suppressor tumoral [Cancer Biology – PTEN and the one thousand plus one ways of inactivating a tumor suppressor]”, Conference “Genética Molecular – Genes que ditam o nosso quotidiano [Molecular Genetics – Genes that dictate our daily life], Lusófona University, Lisbon, Portugal, 6 June. Conference “Genética Molecular – Genes que ditam o nosso quotidiano [Molecular Genetics – Genes that dictate our daily life]
Universidade Lusófona (Lisbon, Portugal)
2008 “B-cell ontogeny and response to antigenic stimuli – implications for the pathogenesis of chronic lymphocytic leukemia”, Reunião sobre linfomas indolentes [Meeting on indolent lymphomas], Sociedade Portuguesa de Hematologia (Portuguese Hematology Society), Cascais, Portugal, 20 September. Reunião sobre linfomas indolentes [Meeting on indolent lymphomas], Sociedade Portuguesa de Hematologia (Portuguese Hematology Society)
Sociedade Portuguesa de Hematologia (Portuguese Hematology Society) (Cascais, Portugal)
2008 “Flow Cytometry Applications”, Sixth Flow Cytometry Workshop, Flow Cytometry Unit, IMM, Lisbon, Portugal, 2 April. Sixth Flow Cytometry Workshop
(Lisbon, Portugal)
2008 “Signal Transduction Aberrations in Cancer” and “’Novel’ Concepts in Cancer Signal Transduction”, Advanced Course on Oncobiology, BEB PhD Program of the Center for Neuroscience and Cell Biology (CNC), University of Coimbra, March 10. Advanced Course on Oncobiology, BEB PhD Program of the Center for Neuroscience and Cell Biology (CNC)
(Coimbra, Portugal)
2008 Cholesterol Promotes Acute Leukemia Progression through Systemic but Selective Endothelial Cell Activation. T. Carvalho, R. Fragoso, A.L. Gomes, C. Casalou, L. Martins, J. Barata and S. Dias (Poster presentation) The American Society of Hematology 50th Annual Meeting
(San Francisco, United States)
2008 Chasing” the IL-7 receptor: Regulation of interleukin 7 receptor a internalization, recycling and degradation by IL-7. C.M.O. Henriques, J. Rino, R.J. Nibbs, G.J. Graham, J.T. Barata* (Poster presentation) British Society for Immunlogy Congress 2008
(Glasgow, United Kingdom)
2008 Cholesterol-Enriched Diet Promotes Leukemia Engraftment and Progression. R. Fragoso, T. Carvalho, A. Gomes, L. Martins, J. Barata, S. Dias (Poster presentation) European Hematology Association - EHA 13th Congress
(Copenhagen, Denmark)
2008 PI3K-Akt signaling pathway is essential for IL-7-mediated proliferation of positively selected human thymocytes, but not for IL-7-dependent viability or differentiation towards CD8+ lineage. L.R. Martins, L. Bicheiro, J.T. Barata* (Poster presentation) SINAL 2008 – 2nd National Meeting of Signal Transduction
(Porto, Portugal)
2008 Interleukin-4 Stimulates Proliferation and Growth of T-Cell Acute Lymphoblastic Leukemia Cells by Activating mTOR Signaling. B.A. Cardoso, L.R. Martins, C. Santos, L.M. Nadler, V.A. Boussiotis, A.A. Cardoso, J.T. Barata* (Poster presentation) SINAL 2008 – 2nd National Meeting of Signal Transduction
(Porto, Portugal)
2008 Posttranslational non-deletional inactivation of PTEN and consequent hyperactivation of PI3K/Akt pathway contribute to primary T-cell leukemia. A. Silva, J.A. Yunes, B.A. Cardoso, L.R. Martins, P.Y. Jotta, M. Abecasis, A.E. Nowill, N.R. Leslie, A.A. Cardoso, J.T. Barata* (Poster presentation) SINAL 2008 – 2nd National Meeting of Signal Transduction
(Porto, Portugal)
2007/11 IL-7 and IL-7R promote T-cell leukemogenesis in vivo. A. Silva, E. Buentke, B. Seddon*, J.T. Barata* XXXIII Annual Meeting of the Portuguese Society of Immunology
SPI - Sociedade Portuguesa de Imunologia (Lisbon, Portugal)
2007 “Leukemia Cells and the Bone Marrow Endothelium”, Vascular Wall and Endothelium Workshop, IMM, Lisbon, Portugal, 14 September. Vascular Wall and Endothelium Workshop
Instituto de Medicina Molecular João Lobo Antunes (Lisbon, Portugal)
2007 “External and cell-autonomous signals in T-cell leukemia”, SINAL – 1st National Meeting on Signal Transduction, Lisbon, 23 March. SINAL – 1st National Meeting on Signal Transduction
(Lisbon, Portugal)
2007 “PTEN, PI3K and IL-7: the ins and outs of T-cell acute leukemia”, IBMC (Institute of Molecular and Cellular Biology), University of Porto, Portugal, 16 November. (Host: Prof. Fernando Arosa).
IBMC (Institute of Molecular and Cellular Biology), University of Porto, Portugal, 16 November. (Host: Prof. Fernando Arosa). (Porto, Portugal)
2007 “Apoptosis in the Immune System”, for the Biochemistry of Cell Death Course run by Prof. Cecilia Rodrigues in the Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal, 9 May. Biochemistry of Cell Death Course
Universidade de Lisboa Faculdade de Farmácia (Lisbon, Portugal)
2007 “Cell Population Analysis by Flow Cytometry”, Introduction to Light Microscopy Course 2007, IMM, Lisbon, 11-13 January. Introduction to Light Microscopy Course 2007
(Lisbon, Portugal)
2007 Posttranslational non-deletional inactivation of PTEN and consequent hyperactivation of PI3K/Akt pathway regulate the viability of primary T-cell leukemias. A. Silva, J.A. Yunes, B.A. Cardoso, L.R. Martins, P.Y. Jotta, M. Abecasis, A.E. Nowill, N.R. Leslie, A.A. Cardoso, J.T. Barata* (Poster presentation) British Assossiation for Cancer Research Meeting on "Cancer Signalling and Novel Cancer Therapeutics"
(London, United Kingdom)
2007 Effects of IL-7 on the late stages of human thymocyte development. L.R. Martins, L. Bicheiro, J.T. Barata* (Poster presentation) XXXIII Annual Meeting of the Portuguese Society of Immunology
(Lisbon, Portugal)
2007 STAT activation contributes to IL-7-mediated growth, viability and cell cycle progression of T-cell acute lymphoblastic leukemia cells. C. Santos, L. Vinagre, A. Silva, B.A. Cardoso, L.R. Martins, A.A. Cardoso, J.T. Barata* (Poster presentation) XXXIII Annual Meeting of the Portuguese Society of Immunology
(Lisbon, Portugal)
2007 Molecular mechanisms of activation of human ¿¿ T cells by non-peptidic phosphoantigens. D. Correia, F. D’Orey, B.A. Cardoso, J.T. Barata, B. Silva-Santos (Poster presentations) XXXIII Annual Meeting of the Portuguese Society of Immunology
(Lisbon, Portugal)
2007 Human naïve CD4+CD45RA+CD31+ recent thymic emigrants can be maintained by IL-7. R. Azevedo, M.V.D. Soares, J.T. Barata, A.E. Sousa (Poster presentation) XXXIII Annual Meeting of the Portuguese Society of Immunology
(Lisbon, Portugal)
2007 TAL1 and LMO2 in T-cell Acute Lymphoblastic Leukemia: Origin or consequence? B.A. Cardoso, J. Gonçalves, J.T. Barata* (Poster presentation) SINAL – 1st National Meeting on Signal Transduction
(Lisbon, Portugal)
2007 Regulation of Motility and Migration of Leukemia T-Cells by IL-7-Mediated Signaling. C.M.O. Henriques, J.T. Barata* (Poster presentation) SINAL – 1st National Meeting on Signal Transduction
(Lisbon, Portugal)
2007 Determining the role of IL-7 in the induction and maintenance of leukaemia in an inducible IL-7R transgenic mouse model. A. Silva, E. Buentke, J.T. Barata, B. Seddon (Poster presentation) Keystone Symposium on ‘Jaks, Stats and Immunity
(Steamboat Springs, United States)
2006/12 PTEN Inactivation Plays A Key Role In Primary T-Cell Acute Lymphoblastic Leukemia Maintenance. A. Silva, J.A. Yunes, P. Jotta, M. Abecasis, A.A. Cardoso, J.T. Barata*. XV National Congress of Biochemistry
SPB - Sociedade Portuguesa de Bioquímica (Aveiro, Portugal)
2006/05 Upregulation of Reactive Oxygen Species is Essential for IL-7-mediated Viability of Leukemia T-cells. A. Silva, J.T. Barata*. II Workshop on Clinical Biochemistry
(Porto, Portugal)
2006/05 Up-regulation of Intracellular Reactive Oxygen Species is Essential for IL-7-mediated Viability of Leukemia T-cells. A. Silva, J.T. Barata* II National Symposium on Cytokines
(Coimbra, Portugal)
2006 “Interleukin-7, PI3K and PTEN in Primary T-Cell Acute Lymphoblastic Leukemia”, Symposium on “Regulation of Protein Synthesis and Intracellular Signaling Mechanisms” (3 July), XXXV Annual Meeting of The Brazilian Society of Biochemistry and Molecular Biology (SBBq), Águas de Lindóia, SP, Brazil, 1-4 July. Symposium on “Regulation of Protein Synthesis and Intracellular Signaling Mechanisms”
(Águas de Lindóia, Brazil)
2006 “Microenvironmental and cell-autonomous signals in leukemia: IL-7, PI3K and T-ALL”, Barts and The London School of Medicine, London, UK, 7 September. (Host: Dr. Georges Vassaux).
Barts and The London School of Medicine, London, UK, 7 September. (Host: Dr. Georges Vassaux). (London, United Kingdom)
2006 “PI3K and IL-7: In and Out of Acute T-cell Leukemia”, National Laboratory of Light “Sincroton”, Campinas, SP, Brazil, 30 June. (Host: Prof. Nilson Zanchin).
National Laboratory of Light “Sincroton”, Campinas, SP, Brazil, 30 June. (Host: Prof. Nilson Zanchin). (Campinas, Brazil)
2006 Interplay between PI3K pathway and intracellular ROS is essential for IL-7-mediated viability of leukaemia T-cells. A. Silva, I. Cebola, J.T. Barata* (Poster presentation) Genes and Cancer Meeting 2006
(Coventry, United Kingdom)
2006 IL-7-mediated Viability of Acute Lymphoblastic Leukemia T-cells is Modulated by Intracellular Reactive Oxygen Species. A. Silva, I. Cebola, J.T. Barata* (Poster presentation) Sixth ESH - UT MD Anderson Cancer Center Interdisciplinary Euroconference on Mechanisms of Cell Death and Disease: Advances in Therapeutic Intervention and Drug Development
(Cascais, Portugal)
2006 A expressão do gene SLIT-1 nas leucemias agudas é restrita às Leucemias Linfoides Agudas de linhagem T [The expression of the gene SLIT-1 in acute leukemias is restricted to acute lymphoid leukemias of T-cell lineage]. P.Y. Jotta, P.R. Oblessuc, B. Cardoso, J.T. Barata, S.R. Brandalise, A.A. Cardoso, J.A. Yunes (Poster presentation) 52nd Brazilian Congress of Genetics
(Foz do Iguaçu, Brazil)
2006 PTEN Inactivation Plays A Key Role In Primary T-Cell Acute Lymphoblastic Leukemia Maintenance. A. Silva, J.A. Yunes, P. Jotta, A.A. Cardoso, J.T. Barata* (Poster presentation) II Workshop on Clinical Biochemistry
(Porto, Portugal)
2006 PTEN Inactivation and PI3K-Akt/PKB Constitutive Overactivation in Primary T-Cell Acute Lymphoblastic Leukemia. A. Silva, J.A. Yunes, A.A. Cardoso, J.T. Barata* (Poster presentation) First ESH - AACR Conference on Molecular Basis for Targeted Therapy for Leukaemia
(Cascais, Portugal)
2005 “Interleucinas na Leucemia de Células T [Interleukins in T-cell Leukemia]”, II Scientific Symposium – Immunology, MedUBI, University of Beira Interior, Covilhã, Portugal, 12 May. II Scientific Symposium – Immunology
Universidade da Beira Interior (Covilhã, Portugal)
2005 “External Signals in Leukemogenesis: IL-7 and Human T-cell Leukemia”, Department of Immunology, University Medical Center, Utrecht, The Netherlands, 28 June. (Host: Prof. Paul Coffer).
Department of Immunology, University Medical Center, Utrecht, The Netherlands, 28 June. (Host: Prof. Paul Coffer). (Utrecht, Netherlands)
2005 “IL-7-Mediated Signals in T-cell Acute Lymphoblastic Leukemia”, NIMR (National Institute for Medical Research), Mill Hill, London, UK, 17 March. (Host: Dr. Benedict Seddon).
NIMR (National Institute for Medical Research), Mill Hill, London, UK, 17 March. (Host: Dr. Benedict Seddon). (London, United Kingdom)
2005 “External Signals in Leukemogenesis: Can IL-7 Play a Role in T-cell Leukemia?”, Instituto Português de Oncologia Francisco Gentil – IPOFG (Portuguese Institute of Oncology Francisco Gentil), Lisbon, Portugal, 8 May. (Host: Dr. Sérgio Dias).
Instituto Português de Oncologia Francisco Gentil – IPOFG (Portuguese Institute of Oncology Francisco Gentil), Lisbon, Portugal, 8 May. (Host: Dr. Sérgio Dias). (Lisbon, Portugal)
2005 “The Role of IL-7 in Acute T-cell Leukemia”, for the Immunology Course run by Prof. Maria Margarida Telhada in the Faculty of Sciences, University of Lisbon, Portugal, 9 May. Immunology Course run by Prof. Maria Margarida Telhada
Universidade de Lisboa Faculdade de Ciências (Lisbon, Portugal)
2005 “Vias de sinalização aberrantes em cancro [Aberrant signal transduction pathways in cancer]”(together with Dr. Sara Vieira), Cancer Molecular and Cellular Biology Course: Introduction to the Molecular and Cellular Mechanisms of Cancer, IPOFG, Lisbon, Portugal, 2-4 March. Cancer Molecular and Cellular Biology Course: Introduction to the Molecular and Cellular Mechanisms of Cancer
Instituto Português de Oncologia de Lisboa - Francisco Gentil (Lisbon, Portugal)
2005 Constitutive over-activation of PI3K-AKT/PKB pathway in primary T-cell acute lymphoblastic leukemia. A. Silva, A.A. Cardoso, J.T. Barata* (Poster presentation) EMBO/FEBS Advanced Lecture Course: Molecular Mechanisms in Signal Transduction and Cancer
(Spetses, Greece)
2004/12 Murine IL-7 mimics the functional and molecular effects of human IL-7 on normal and malignant human T cells. J.T. Barata, A. Silva, A.A. Cardoso. XIV National Congress of Biochemistry
SPB - Sociedade Portuguesa de Bioquímica (Vilamoura, Portugal)
2004/12 mTOR as Therapeutic Target for T-Cell Leukemia: Synergism with Conventional Cytotoxic Drugs and Signaling Inhibitors. A. Batista, J.T. Barata, L.F. Costa, S.E. Sallan, N. Carlesso, L.M. Nadler, A.A. Cardoso. The American Society of Hematology 46th Annual Meeting
ASH - American Society of Hematology (San Diego, United States)
2004 “IL-7 Signaling in the Biology of T-cell Acute Leukemia”, IBMC (Institute of Molecular and Cellular Biology), University of Porto, Portugal, 7 June. (Host: Prof. Alexandre do Carmo).
IBMC (Institute of Molecular and Cellular Biology), University of Porto, Portugal, 7 June. (Host: Prof. Alexandre do Carmo). (Porto, Portugal)
2004 “Interleukin-7-mediated signaling in the biology of T-cell acute lymphoblastic leukemia”, IGC (Institute Gulbenkian of Science), Oeiras, Portugal, 20 February. (Host: Prof. Leonor Parreira)
IGC (Institute Gulbenkian of Science), Oeiras, Portugal, 20 February. (Host: Prof. Leonor Parreira) (Oeiras, Portugal)
2004 Crosstalk between Breast Cancer Cells and Bone Marrow Endothelium Require the Engagement of PI3K/Akt Signaling. J.G. Brandao, J.T. Barata, R. Nunes, L.M. Nadler, A.A. Cardoso (Poster presentation) The American Society of Hematology 46th Annual Meeting
(San Diego, United States)
2003 An IL-7-Dependent Human Leukemia T-Cell Line as a Valuable Tool for Drug Discovery in T-ALL. J.T. Barata, V.A. Boussiotis, J.A. Yunes, A.A. Ferrando, L. Moreau, J.P. Veiga, S.E. Sallan, A.T. Look, L.M. Nadler, A.A. Cardoso (Poster presentation) .The American Society of Hematology 45th Annual Meeting
(San Diego, United States)
2002/12 PI3K/PKB(Akt) is the dominant pathway regulating interleukin-7 mediated survival, activation and cell cycle progression of T-cell acute lymphoblastic leukemia (T-ALL) cells. J.T. Barata, A.A. Cardoso, J.G. Brandão, L.M. Nadler, V.A. Boussiotis. The American Society of Hematology 44th Annual Meeting
ASH - American Society of Hematology (Philadelphia, United States)
2002 PI-3K/Akt(PKB) pathway is critical for interleukin-7-mediated survival, activation and cell cycle progression of T-cell acute lymphoblastic leukemia (T-ALL) cells. J.T. Barata, A.A. Cardoso, J.G. Brandão, L.M. Nadler, V.A. Boussiotis (Poster presentation) 31st Annual Meeting of The International Society for Experimental Hematology
(Montreal, Canada)
2001 “Cytokine-mediated signal transduction”, Module of Molecular Immunology from the Program on Basic and Applied Biology (GABBA), IBMC, University of Porto, Portugal. Module of Molecular Immunology from the Program on Basic and Applied Biology (GABBA)
Universidade do Porto Instituto de Biologia Molecular e Celular (Porto, Portugal)
2001 IL-7 promotes viability and cell cycle progression of T cell acute lymphoblastic leukemia (T-ALL) cells through p27kip1 downregulation: relative contribution of Jak/Stat, PI3K/Akt and MAPK pathways. J.T. Barata, A.A. Cardoso, L.M. Nadler, V.A. Boussiotis (Poster presentation) 27th Meeting of the Federation of European Biochemical Societies
(Lisbon, Portugal)
2000/12 Downregulation of p27kip1 by IL-7 is mandatory for induction of bcl-2, promotion of viability and cell cycle progression in T cell acute lymphoblastic leukemia cells. J.T. Barata, A.A. Cardoso, S.E. Sallan, L.M. Nadler, V.A. Boussiotis. The American Society of Hematology 42nd Annual Meeting
ASH - American Society of Hematology (San Francisco, Portugal)
2000/11 Interleukin-7 promotes cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells through downregulation of p27kip1. J.T. Barata, A.A. Cardoso, L.M. Nadler, V.A. Boussiotis. XXVI Annual Meeting of the Portuguese Society of Immunology
SPI - Sociedade Portuguesa de Imunologia (Porto, Portugal)
2000 Tumor/Bone Marrow Dynamic Reciprocity: Intimate Interactions With Endothelium May Confer Selective Advantage to Breast Cancer Cells. R.A. Nunes, J.P. Veiga, J.T. Barata, L.M. Nadler, A.A. Cardoso (Poster presentation) 23rd Annual San Antonio Breast Cancer Symposium
(San Antonio, United States)
2000 Molecular control of clonal expansion in T-ALL by IL-4 and IL-7. J.T. Barata, A.A. Cardoso, J. Donovan, L.M. Nadler, V.A. Boussiotis (Poster presentation) Signaling 2000 Keystone Symposium on Molecular & Cellular Biology
(Keystone, United States)
1999/12 Peroxisome proliferator-activated receptor-y (PPARy) expression by bone marrow endothelium reveals a potential target for therapeutic intervention in acute lymphoblastic leukemia. J.P. Veiga, T.D. Keenan, J.T. Barata, S.E. Sallan, L.M. Nadler, A.A. Cardoso. The American Society of Hematology 41st Annual Meeting
ASH - American Society of Hematology (New Orleans, Portugal)
1999 Identification of molecular targets regulating growth of childhood T cell leukemia by IL-4 and IL-7. J.T. Barata, A.A. Cardoso, J. Donovan, L.M. Nadler, V.A. Boussiotis (Poster presentation) The American Society of Hematology 41st Annual Meeting
(New Orleans, United States)
1994/09 Plant-parasitic nematodes associated with fig trees in Portugal. I.M. de O. Abrantes, M.S.N. de A. Santos, J.P.T. Barata & N. Vovlas. 9th Congress of the Mediterranean Phytopathological Union
(Kusadasi, Turkey)
1993/12 Nemátodes-das-galhas-radiculares, Meloidogyne spp., parasitas da figueira (Ficus carica L.) em Portugal. [Root-knot nematodes, Meloidogyne spp., parasites of Fig Tree (Ficus carica L.) in Portugal]. I.M. de O. Abrantes, J.P.T. Barata, M.S.N. de A. Santos & Z.M.C. de A. Trindade. 2nd Meeting of Portuguese Phytopathologists
(Coimbra, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023 - Current Maria Silva - MSc Student
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2023 - Current Lena Schobloch (Germany, spring internship)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2022 - Current Maria-Eva Zimzik (Germany, SCORE summer internship for medical students)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2022 - Current Germano Vicente (Portugal, Maria de Sousa GABBA summer internship)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2022 - Current Audrey Mansilha (France, autumn internship)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2021 - Current Mafalda Duque - PhD student (Supervisor: Dr. Rita Fragoso)
Co-supervisor
2021 - Current Miguel Martins - MSc student (Supervisor: Dr Joaquin Duarte)
Co-supervisor of Miguel Martins
2020 - Current Ana Cachucho - PhD Student
Supervisor
2019 - Current Carlos Custódia - PhD student (Supervisor: Dr. Cláudia Faria, IMM/FMUL)
Co-supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2019 - Current Hannah Taylor (USA, winter internship)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2018 - Current Marta B. Fernandes - PhD student
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2018 - Current Veronika Waas (Germany, summer internship)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2018 - Current Françoise Sanderse (Belgium, summer internship within collaborative work with Ghent University - group of Prof. Pieter Van Vlierberghe)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2017 - Current Luís Monteiro - PhD student
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2017 - Current Nina Fraticelli Guzman (USA, summer internship)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2015 - Current Yolanda Afonso (Portugal, spring internship)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2014 - Current Inês Pinto (Portugal, summer intership)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2014 - Current Rita Cabrita (Portugal, summer internship)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2013 - Current Rita Fragoso - Staff Scientist
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2013 - Current Josep Sampedro Soler (Spain, summer internship)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2013 - Current Joana Ferreira (Portugal, summer internship)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2013 - Current Ana Bolhaqueiro (Portugal, spring internship)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2012 - Current Susana Santos (Portugal, summer internship)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2011 - Current Michael Svaton (Chec Republic, SCORE summer internship for medical students)
Supervisor
2011 - Current Ahmed Bahaeldin Abdelaal (Egipt, high school student; summer internship)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2011 - Current Nuno Guerra (Portugal, summer internship)
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2010 - Current “The role of CK2 in IL-7-mediated signaling in T-cell leukemia” - Maureen Spit (Supervisor) - Minor research project
Supervisor
Universiteit Utrecht, Netherlands
2009 - Current “The role of PTEN, CK2 and the PI3K/Akt pathway in B cell acute lymphoblastic leukemia (B-ALL)” - Marie Tazreiter
Supervisor
Universität Wien, Austria
2005 - Current Supervisor of numerous students/technicians (BI - “bolseiros de Investigação”) integrated into the different funded research projects that I have been leading. Given our policy of stimulating young students with interest and potential to follow a scientific research career, also have been supervising numerous short-term interns throughout the years.
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2022 - 2024 Joana Cavaco - MSc Student (Supervisor: Dr. Rita Fragoso, iMM)
Co-supervisor
2017 - 2024 Eunice Paisana - PhD student (Supervisor: Dr. Cláudia Faria, IMM/FMUL)
Co-supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2023/01 - 2023/09 Alessia de Stefano, PhD student (Italy). Trained in the lab for 9 months (January-September) as part of her PhD project, supervised by Prof. Matilde Y. Follo (University of Bologna, Italy).
Co-supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2022 - 2023 Pedro Rosado - MSc Student
Supervisor
2022 - 2023 Hélio Crespo - PostDoc
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2021 - 2023 João Fontela - MSc student
Supervisor of João Fontela
2021 - 2023 Sara Gama - MSc student
Supervisor
2021 - 2023 Patrícia Amaral - MSc student
Supervisor
2018 - 2023 Rita Cascão - Senior Post-Doctoral Researcher
Co-supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2014 - 2023 Cláudia Faria - Senior Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2015 - 2022/12/22 Mariana L. Oliveira - PhD student
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2021 - 2022 Oncogenic Transcription Factors in T-cell Acute Lymphoblastic Leukemia: a review and identification of a novel player – CASZ1”, Integrated MSc in Medicine, Faculty of Medicine, Lisbon University.
Supervisor of Francisco Alexandrino
Universidade de Lisboa Faculdade de Medicina, Portugal
2020 - 2022 Susana Moleirinho - Postdoc
Supervisor
2020 - 2022 Tatiana Araújo - MSc student
Supervisor
2020 - 2021 Rita Alexandra Nunes Rodrigues, Project # 20210010: “CK2, PI3K-AKT pathway & the Circadian Molecular Clock: decoding the molecular interactions network”. GAPIC program for medical students (Programa Educação Pela Ciência), Faculty of Medicine of Lisbon University.
Supervisor
2020 - 2021 Juliana Ronchi, PhD student (Brazil). Trained in the lab for more than 1 year as part of her PhD project, sponsored by FAPESP (Brazil), within a collaboration with the lab of Dr. J. Andres Yunes (Centro Infantil Boldrini, Campinas, SP, Brazil), PhD thesis supervisor.
Co-supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2020 - 2021 Rita Alexandra Nunes Rodrigues, Project # 20210010: “CK2, PI3K-AKT pathway & the Circadian Molecular Clock: decoding the molecular interactions network”. GAPIC program for medical students (Programa Educação Pela Ciência), Faculty of Medicine of Lisbon University.
Supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 - 2021 João Neto - Post-Doctoral Researcher
Supervisor
2019 - 2021 Clara Dias - Post-Doctoral Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2019 - 2021 "The impact of IL-7 on metabolic reprogramming in T-cell acute lymphoblastic leukemia”, for the MSc in Biotechnology, Wien University, Austria
Supervisor of Brian Ringhofer
2017 - 2021 Daniel Ribeiro - Post-Doctoral Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2016 - 2021 Bruno Cardoso - Senior Post-Doctoral Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2017 - 2020 Sara Rocha - PhD student (Supervisor: Dr. Carla Oliveira, IPATIMUP)
Co-supervisor
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2018 - 2019 Francisco Alexandrino, Project #20190012. GAPIC program for medical students (Programa Educação Pela Ciência), Faculty of Medicine of Lisbon University.
Supervisor
2018 - 2019 Francisco Alexandrino, Project #20190012. GAPIC program for medical students (Programa Educação Pela Ciência), Faculty of Medicine of Lisbon University.
Supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2019 Afonso Almeida - Senior Post-Doctoral Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2015 - 2019 A systematic pan-cancer analyzis of somatic variants reveals epigentic drivers of intratumor heterogeneity" - Mafalda Ramos Matos, PhD (2019; Supervisor: Prof. Sérgio Almeida, IMM/FMUL).
Co-supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2018 Gonçalo Lopes Martins Pereira, Project #20180017. GAPIC program for medical students (Programa Educação Pela Ciência), Faculty of Medicine of Lisbon University.
Supervisor
2017 - 2018 Gonçalo Lopes Martins Pereira, Project #20180017. GAPIC program for medical students (Programa Educação Pela Ciência), Faculty of Medicine of Lisbon University.
Supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2018 Teresa Serafim - Lab Manager/Post-Doctoral Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2013 - 2018 Isabel Alcobia - Staff Scientist
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2017 - 2017 Nina Fraticelli Guzman (USA, summer internship)
Supervisor
2016 - 2017 Andreia Amaral - Post-Doctoral Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2016 - 2017 “The role of NRARP in the pathogenesis of T-cell Acute Lymphoblastic Leukemia” - Inês Pinto - Msc. student (Supervisor: Dr. Rita Fragoso IMM).
Co-supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2016 Raquel Linheiro - Post-Doctoral Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2009 - 2016 Leonor M. Sarmento - Senior Post-Doctoral Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2015 - 2015 Nádia Correia - Post-Doctoral Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2015 - 2015 Yolanda Afonso (Portugal, spring internship)
Supervisor
2014 - 2015 Hugo Filipe Loureiro Cadilha. Project #20150037. GAPIC program for medical students (Programa Educação Pela Ciência), Faculty of Medicine of Lisbon University.
Supervisor
2014 - 2015 Hugo Filipe Loureiro Cadilha. Project #20150037. GAPIC program for medical students (Programa Educação Pela Ciência), Faculty of Medicine of Lisbon University.
Supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2014 Rita Cabrita (Portugal, summer internship)
Supervisor
2012 - 2014 Leila Martins - Post-Doctoral Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2013 - 2013 Yasser Perea - Visiting Post-Doctoral Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2013 - 2013 Ana Bolhaqueiro (Portugal, spring internship)
Supervisor
2013 - 2013 Joana Ferreira (Portugal, summer internship)
Supervisor
2013 - 2013 Josep Sampedro Soler (Spain, summer internship)
Supervisor
2012 - 2013 João Tavanez - Post-Doctoral Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2012 - 2013 Maria Inês Felizardo Lopes. Project #20130007/PEC/BG. GAPIC program for medical students (Programa Educação Pela Ciência), Faculty of Medicine of Lisbon University.
Supervisor
2012 - 2013 Maria Inês Felizardo Lopes. Project #20130007/PEC/BG. GAPIC program for medical students (Programa Educação Pela Ciência), Faculty of Medicine of Lisbon University.
Supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2013 Ana Gírio - Post-Doctoral Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2012 - 2012 Susana Santos (Portugal, summer internship)
Supervisor
2011 - 2012 Marta Cancella de Abreu. Project #20120030. GAPIC program for medical students (Programa Educação Pela Ciência), Faculty of Medicine of Lisbon University.
Supervisor
2011 - 2012 Marta Cancella de Abreu. Project #20120030. GAPIC program for medical students (Programa Educação Pela Ciência), Faculty of Medicine of Lisbon University.
Supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2009 - 2012 Inês Antunes - Post-Doctoral Researcher
Supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2011 - 2011 Nuno Guerra (Portugal, summer internship)
Supervisor
2011 - 2011 Ahmed Bahaeldin Abdelaal (Egipt, high school student; summer internship)
Supervisor
2011 - 2011 Michael Svaton (Chec Republic, SCORE summer internship estágio for medical students)
Supervisor
2003 - 2005 Collaborated in the supervision of two PhD students, Joana Brandão and Ana Batista in the Tumor Biology Unit, Institute of Molecular Medicine, Faculty of Medicine of Lisbon University, Portugal.
Co-supervisor
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
1998 - 2001 Lab work supervision of several undergraduate students in short-term research projects performed at the Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Co-supervisor
Dana Farber Cancer Institute, United States

Event organisation

Event name
Type of event (Role)
Institution / Organization
2018/09/21 - 2018/09/22 Organizer (with Peter Jordan and Duarte Barral), and co-Chair of Session 4 (with Alexandre do Carmo), SINAL 2018 – 9th Meeting on Signal Transduction, Teatro Thalia, Lisbon, Portugal, 21-22 September. (2018/09/21 - 2018/09/22)
Congress (Co-organisor)
2017/06/22 - 2017/06/22 Organizer (with Iñaki Martin-Subero and Juan Bueren), YoungEHA Research Meeting on Molecular Aspects of Hematological Disorders, Madrid, Spain, 22 June. (2017/06/22 - 2017/06/22)
Conference (Member of the Organising Committee)
2017/06/01 - 2017/06/02 Organizer (with Peter Jordan, Duarte Barral and François Radvanyi), and co-Chair of Session 2 (with Alexandre do Carmo), SINAL 2017 – 8th Meeting on Signal Transduction, Pavilhão do Conhecimento, Lisbon, Portugal, 1-2 June. (2017/06/01 - 2017/06/02)
Congress (Co-organisor)
2017/05/29 - 2017/05/31 Organizer (with François Radvanyi), ReTuBi Twinning network 2017 Summer School, Oceanário de Lisboa, Lisbon, Portugal, 29-31 May. (2017/05/29 - 2017/05/31)
Congress (Co-organisor)
2010/04 - 2010/05 Organizer, Cancer Course for the IMM International PhD Program, IMM, Lisbon, Portugal, 19-21 April and 17-18 May. (2010/04 - 2010/05)
Workshop (Member of the Organising Committee)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2009/04/27 - 2009/04/30 Organizer, Cancer Course for the IMM International PhD Program, IMM, Lisbon, Portugal, 27-30 April. (2009)
Workshop (President of the Organising Committee)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2008/02/19 - 2008/02/22 Organizer, Fifth Flow Cytometry Workshop, Flow Cytometry Unit, IMM, Lisbon, Portugal, 19-22 February. (2008)
Workshop (President of the Organising Committee)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2007/11/14 - 2007/11/16 Member of the local organizing committee at IMM, XXXIII Annual Meeting of the Portuguese Society of Immunology, Lisbon, Portugal, 14-16 November. (2007)
Congress (Member of the Organising Committee)
Sociedade Portuguesa de Imunologia, Portugal
2007/03/23 - 2007/03/23 Organizer, SINAL – 1st National Meeting on Signal Transduction, IMM/FML, Lisbon, Portugal, 23 March (Together with Peter Jordan). (2007)
Conference (Co-organisor)
2007/02 - 2007/02 Organizer, Third and Fourth Flow Cytometry Workshops, Flow Cytometry Unit, IMM, Lisbon, Portugal, 29 January – 1 February and 14-16 February. (2007)
Workshop (President of the Organising Committee)
2006/05/15 - 2006/05/19 Co-organizer, Second Flow Cytometry Workshop, Flow Cytometry Unit, IMM, Lisbon, Portugal, 15-19 May. (2006)
Workshop (Co-organisor)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2005 - 2006 Organizer of the Monday International Seminars of IMM (Together with António Jacinto, Maria Mota and Maria Soares). (2005 - 2006)
Seminar (Co-organisor)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2005 - 2005 Organizer of the inter-departmental informal seminars (“Cake seminars”) and the Friday External Seminars of IMM (Together with António Jacinto, Maria Mota and Maria Soares). (2005)
Seminar (Co-organisor)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
1999/11/20 - 1999/11/21 Organization collaborator, Portugal: Strategic Options in a European Context, Minda de Gunzburg Center for European Studies, Harvard University, Cambridge, MA, USA, 20-21 November. (1999)
1995/07/16 - 1995/07/28 Member of the Organizing Committee, Course on Quality Management, University of Coimbra, Portugal, 16-28 July. (1995 - 1995)
Workshop (Member of the Organising Committee)
1993/12/02 - 1993/12/03 Organization collaborator, 2nd Meeting of Portuguese Phytopathologists, University of Coimbra, Coimbra, Portugal, 2-3 December. (1993 - 1993)
Meeting (Member of the Organising Committee)
1992/04/11 - 1992/04/17 Organization collaborator, 21st International Nematology Symposium, European Society of Nematologists (ESN), Albufeira, Portugal, 11-17 April. (1992 - 1992)
Symposium (Co-organisor)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2022/09/29 - Current Co-moderator (together with Luisa Lopes) of the morning session, iMM Post-Doc Day, Lisbon, Portugal, 29 September.
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2021/03 - Current Online Meeting Functional Precision Medicine in Blood Cancer, Comprehensive Cancer Center Zürich, 25-26 March.
2023/12/09 - 2023/12/12 Chair of Session 603. Lymphoid Oncogenesis – basic. Mechanisms of acute lymphoblastic leukemia development and progression. 65th ASH Annual Meeting, San Diego, CA, USA, 9-12 December.
Conference
65th ASH Annual Meeting
2022/10/04 - 2022/10/05 Chair of Session XI: Leukaemia and Lymphoma, 63rd Advances in Biological Regulation Symposium, University of Bologna
2022/06/30 - 2022/07/01 Co-chair of the EACR and ASEICA plenary lectures, 5th ASPIC International Congress, Porto, Portugal, 30 June - 1 July
2021/03/25 - 2021/03/26 Online Meeting Functional Precision Medicine in Blood Cancer, Comprehensive Cancer Center Zürich, 25-26 March.
Conference
Online Meeting Functional Precision Medicine in Blood Cancer
Comprehensive Cancer Center Zürich, Switzerland
2019/05/20 - 2019/05/20 “Sinalização em cancro: travões, reviravoltas, música e um pouco de literatura na procura de novos tratamentos [Signaling in cancer: breaks, turns, music and a little bit of literature while seeking for new treatments]”, Pint of Science Festival, Lisboa, Portugal, 20 May.
Round table
2018/02/02 - 2018/02/02 “ABC do cancro (e um pouco de investigação) em 60 minutos [ABC of cancer (and a little bit of research) in 60 minutes]”, High School Colégio Rainha D. Leonor, Caldas da Rainha, Portugal, 2 February.
Round table
2018 - 2018 Entry Level Bioinformatics, Gulbenkian Training Programme in Bioinformatics, Instituto Gulbenkian de Ciência, 19-23 February.
Workshop
Instituto Gulbenkian de Ciência, Portugal
2017/06/22 - 2017/06/25 Chair, Basic-Science-in-Focus session on: Mouse models of acute leukemia (Sunday, 25 June), 22nd Congress of the European Hematology Association, Madrid, Spain, 22-25 June.
Congress
European Hematology Association, Netherlands
2016/06/01 - 2016/06/03 Co-Chair (with Karine Serre), Immunotherapies (2 June) and Cancer Immunotherapy (3 June) Sessions, XLII Annual Meeting of the Portuguese Society of Immunology, Oeiras, 1-3 June.
Congress
Sociedade Portuguesa de Imunologia, Portugal
2015/02/25 - 2015/02/25 “Em busca de novas terapias para o cancro [A quest for new therapies against cancer]”, Maria Amália Vaz de Carvalho High School, Lisboa, Portugal, 26 February.
Round table
2014 - 2014 EHA-SWG Scientific Meeting on “New molecular insights in emerging therapeutic strategies in Acute Lymphoblastic Leukemia (ALL)”, 28 February - 2 March.
Meeting
2013/03/22 - 2013/03/24 Co-Chair (with Jon Aster), Session II; and co-chair (with Jan Cools), Session V; Second ESH-EHA Scientific Workshop on T-cell Acute Lymphoblastic Leukemia, Lisbon, Portugal, 22-24 March.
Conference
2012/04/19 - 2012/04/20 Co-Chair (with John Blenis), Session I (mTOR and Cancer), XXI Porto Cancer Meeting (on Metabolism and Cancer – from Etiopathogenesis to Therapy), Porto, Portugal, 19-20 April.
Conference
2012/03/05 - 2012/03/08 Co-Chair (with Silvio Perea), Cancer Biology and Treatment session, International Meeting Biotecnología Habana 2012 – Medical Applications of Biotechnology, Havana International Conference Center, Havana, Cuba, 5-8 March.
Congress
2012 - 2012 The Fourth Champalimaud Cancer Symposium – Early Cancer Detection and Treatment, Lisbon, Portugal, 15 June.
Symposium
2011 - 2011 Thymus@Porto Workshop, IBMC, Porto, Portugal, 14 October.
Workshop
2011 - 2011 Champalimaud Cancer Research Symposium 2011, Lisbon, Portugal, 14-15 January.
Symposium
2009/05/29 - 2009/05/30 Co-Chair, Day 2 session, SINAL 2009 – 3rd National Meeting on Signal Transduction, University of Aveiro, Portugal, 29-30 May.
Congress
SINAL 2009 – 3rd National Meeting on Signal Transduction
2009 - 2009 I National Forum of R&D in Health, National Institute of Health Ricardo Jorge, Lisbon, Portugal, 4 September.
Round table
2009 - 2009 Champalimaud Cancer Research Symposium, Lisbon, Portugal, 20 May
Symposium
2006/12/15 - 2006/12/19 Chair, Session VII: Angiogenesis/Medicine, First Annual Meeting of Gulbenkian Students, Instituto Gulbenkian de Ciência, Oeiras, Portugal, 15-19 December.
Meeting
Instituto Gulbenkian de Ciência, Portugal
2006 - 2006 Practical Module on “Accomodation, Manipulation and Interventions on Small Laboratory Animals – Rats and mice” of the 1st Course on “Laboratory animal science experimentation”, SPCAL (Portuguese Society for Laboratory Animal Sciences), Instituto Gulbenkian de Ciência, Oeiras, Portugal, 26 and 27 June (12 hours) – Total course: 45 hours.
Other
2006 - 2006 6th International ELMI Meeting and Workshop on Advanced Light Microscopy, Ofir, Portugal, 30 May – 2 June.
Workshop
2006 - 2006 International Course on Toxicology “Smart Toxicology: Subcellular Targets of Anti-cancer Therapy”, Center for Neurosciences and Cell Biology, University of Coimbra, Portugal, 22-24 March.
Workshop
2006 - 2006 Biostatistics module of the 1st Course on “Laboratory animal science experimentation”, SPCAL, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal, 10 and 17 February (10 hours).
Other
2005 - 2005 Workshop on the Mechanisms of T-cell recognition and activation, Instituto de Biologia Molecular e Celular – IBMC (Institute of Molecular and Cellular Biology), University of Porto, Portugal, 28 November.
Workshop
2005 - 2005 Cancer Research Forum, Luso, Portugal, 18 November.
Round table
2005 - 2005 Theoretical module of the 1st Course on “Laboratory animal science experimentation”, SPCAL, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal, 17-19 October (23 hours).
Other
2004 - 2004 Chair, 1st session on Immunology, Joint Meeting of Graduate Programmes on Biosciences, Hotel Vila Galé, Porto, Portugal, 16-20 December.
Meeting
Joint Meeting of Graduate Programmes on Biosciences
2004 - 2004 GABBA Mini-Symposium on Lymphocyte Biology “Complexity and Plasticity of Lymphocyte Differentiation”, IBMC, University of Porto, Portugal, 15 December.
Symposium
2004 - 2004 Theoretical part of the course on Microarrays: Principles and Applications in Medicine, School of Health Sciences, University of Minho, Braga, Portugal, 24-25 May.
Other
2004 - 2004 Workshop on Gene Expression and Cellular Responses, IBMC, University of Porto, Portugal, 16 January.
Workshop
2003/12/18 - 2003/12/19 Co-chair, Day 2 Session 2, GABBA Annual Scientific Meeting, IPATIMUP, Porto, Portugal, 18-19 December.
Meeting
GABBA Annual Scientific Meeting
2003 - 2003 Workshop ‘The Immunological Synapse’, IBMC, University of Porto, Portugal, 16 May.
Workshop
2000 - 2000 EMBO Practical Course on Lentiviral Vectors For Gene Transfer (supervised by Prof. Luigi Naldini), Institute for Cancer Research and Treatment, University of Turin, Italy, 25-30 September.
Workshop
1998 - 1998 Investing in the Future: Industry/University Collaborations, Portuguese-American Post-graduate Society Forum, MIT Sloan School of Management, Cambridge, MA, USA, 24 October.
Round table
1997 - 1997 Molecular and Cellular Components of the Immune System, European Network of Immunology Institutes, Les Embiez, France, 21-25 May.
Symposium
1997 - 1997 Advanced International Course on Regulatory Mechanisms Involved in Cell Ageing and Death, IBMC, University of Porto, Portugal, 12-20 May.
Other
1997 - 1997 Advanced International Course on Oncobiology: Cell Migration and Cell Invasiveness in Oncobiology, IPATIMUP, University of Porto, Portugal, 14-24 April.
Other
1996 - 1996 Course: From Biosystems to Bioprocess Engineering - An Interdisciplinary Challenge, Board of European Students of Technology, Rome, Italy, 8-20 September.
Other
1994 - 1994 Life Cycle Assessment Course, Board of European Students of Technology, Göteborg, Sweden, 15-26 August.
Other
1993 - 1994 Scientific Illustration Course, Portuguese Biologists Association, Coimbra, Portugal, 3 December – 15 January.
Other

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2023/12/20 “Study of the impact of the IL-7R on non-small cell lung cancer”.
Supervisor
Pedro Lino Rosado (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/12/07 “Targeting cancer-related proteins: Rational design of covalent inhibitors and degraders for TEC kinases and serine hydrolases”
(Thesis) Arguer
Bárbara Sousa (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2023/12/05 “The involvement of DIS3L2 in nonsense-mediated mRNA decay and its functional networks in cancer”
(Thesis) Main arguer
Juan García-Moreno (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/11/03 “The T cell surface glycoprotein CD6 as an inhibitory receptor and as target for immunomodulation”
(Thesis) Main arguer
Sónia Henriques (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/10/23 “Multiple Roles of PLC¿1 in Mediating Target Therapy Resistance Across Different Tumor Types”
(Thesis) Arguer
Raquel Duarte (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2023/09/29 “High systemic cholesterol and IFN-¿ response in breast cancer cells”
President of the jury
Daniela Botinas (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2023/09/22 “Emerging roles of the critical oncogenic molecule Cadherin-3 in glioblastoma”
(Thesis) Main arguer
Eduarda Martins (PhD)
Universidade do Minho, Portugal
2023/06/27 “Characterizing the role of the Circadian Molecular Clock in T-ALL”
Supervisor
Patrícia Amaral (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2023/06/19 “Molecular and Functional Characterization of Neutrophils in Psoriasis”
(Thesis) Main arguer
Carolina Rodrigues de Souza (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/05/24 “Histone Deacetylase Inhibitors as therapeutic candidates against IL-7-responsive Acute Lymphoblastic Leukemia”
Supervisor
João Fontela (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2023/05/10 “Dynamics and functions of N-glycans in T cell development”
(Thesis) Main arguer
Manuel Vicente (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/04/14 “Regulatory T cell depletion unleashes an IFN¿+ ¿d T cell response in the tumour microenvironment”
President of the jury
André Vaz Pinto Santos (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2023/03/09 Molecular Insights on Acute Lymphoblastic Leukemia Development and Suppression Telmo Catarino (PhD)
2023/03/09 “Molecular Insights on Acute Lymphoblastic Leukemia Development and Suppression”
(Thesis) Main arguer
Telmo Catarino (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/01/26 Exploring the role of HoxA9 in IL7R-mediated B-Cell Leukemogenesis
Supervisor
Sara Gama (Master)
2023/01/26 “Exploring the role of HoxA9 in IL7R-mediated B-Cell Leukemogenesis”
Supervisor
Sara Gama (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2022/12/22 Studying the impact of interleukin-7 receptor on T-cell leukemia using zebrafish models: from basic biology to therapeutics
Supervisor
Mariana Oliveira (PhD)
2022/12/22 “Studying the impact of interleukin-7 receptor on T-cell leukemia using zebrafish models: from basic biology to therapeutics”
Supervisor
Mariana Oliveira (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2022/12/14 Genotyping tumor DNA for precision oncology Catarina Silveira (PhD)
2022/12/14 “Genotyping tumor DNA for precision oncology”
(Thesis) Arguer
Catarina Silveira (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2022/07/15 Tumor infiltrating lymphocytes and PD-1/PD-L1 expression in primary tumors and bone metastases from solid cancers Joaquim Brito (Master)
2022/07/15 “Tumor infiltrating lymphocytes and PD-1/PD-L1 expression in primary tumors and bone metastases from solid cancers”
President of the jury
Joaquim Brito (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2022/04/07 The role of MYH10 in IL-7R-driven B-cell Acute Lymphoblastic Leukemia - Tatiana Araújo (Supervisor)
Supervisor
Tatiana Araújo (Master)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2022/04/07 “The role of MYH10 in IL-7R-driven B-cell Acute Lymphoblastic Leukemia”
Supervisor
Tatiana Araújo (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/09/10 The anti-oncogenic role of stromal p53 in colorectal cancer
President of the jury
Sofia Martins (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/09/10 “The anti-oncogenic role of stromal p53 in colorectal cancer”
President of the jury
Sofia Martins (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/07/16 Cell Competition as a Basal Cell Carcinoma Progression Mechanism and the Potential Therapeutic Effect of Ikaros
President of the jury
Joana Jesus (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/07/16 “Cell Competition as a Basal Cell Carcinoma Progression Mechanism and the Potential Therapeutic Effect of Ikaros”
President of the jury
Joana Jesus (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/07/14 A relação entre a leucemia linfoblástica aguda e crianças com síndrome de Down.
President of the jury
Catarina Santos (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/07/14 Leucemia Linfoblástica Aguda: uso de protocolos pediátricos em adolescentes e adultos jovens.
President of the jury
Helena Boavida (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/07/14 “Leucemia Linfoblástica Aguda: uso de protocolos pediátricos em adolescentes e adultos jovens”
President of the jury
Helena Boavida (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/07/14 “A relação entre a leucemia linfoblástica aguda e crianças com síndrome de Down”
President of the jury
Catarina Santos (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/06/17 Tradução independente de cap da proteína humana up-frameshift 1 (UPF1) e cancro.
President of the jury
Neuza Bacalhau (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/06/17 “Tradução independente de cap da proteína humana up-frameshift 1 (UPF1) e cancro”
President of the jury
Neuza Bacalhau (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/06/15 Impact of the human Golgi anti-apoptotic protein (hGAAP/TMBIM4) in Glioblastoma progression.
President of the jury
Marta Martins (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/06/15 “Impact of the human Golgi anti-apoptotic protein (hGAAP/TMBIM4) in Glioblastoma progression”
President of the jury
Marta Martins (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/05/14 Functional and Metabolic Characterization of Antitumour Macrophages.
President of the jury
Afonso Mota (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/05/14 “Functional and Metabolic Characterization of Antitumour Macrophages”
President of the jury
Afonso Mota (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2020 Regulation of T Cell Fitness and Functions in Tumour Responses - Sofia Mensurado Santos
Thesis Member
Sofia Mensurado Santos (PhD)
2020 Exploring the role of IL-7, CK2, and SphK in T-cell acute lymphoblastic leukemia - Alice Melão (Supervisor)
Supervisor
Alice Melão (PhD)
2019 "Cooperation between IL-7R signaling and HOXA9 in leukemogenesis" - Beatriz Raposo (Supervisor)
Supervisor
Beatriz Raposo (Master)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019 “Deciphering complete cancer transcriptomes from bulk to single cell level”. - Karen Verboom
(Thesis) Main arguer
Karen Verboom (PhD)
Universiteit Gent, Belgium
2019 “ Identification of APOBEC-associated frequent mutations & characterization of FGFR3-driven signaling pathways in bladder cancer” - Mingjun Shi
(Thesis) Main arguer
Mingjun Shi (PhD)
Université Paris-Saclay, France
2019 “Identification of novel potential therapeutic targets for T-cell acute lymphoblastic leukemia” - Catarina Fernandes
(Thesis) Main arguer
Catarina Fernandes - Msc. student (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 “Exploring new facets of interleukin-7 receptor-mediated signaling in T-cell leukemia” - Ana Sofia Ramalho (Supervisor)
Supervisor
Ana Sofia Ramalho - Msc. student (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 “Antibody-based therapy for T-cell acute lymphoblastic leukemia: Targeting the IL-7 receptor” - Padma Akkapeddi (Supervisor)
Supervisor
Padma Akkapeddi (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 Impact of metabolic resources and infiltrating immune cells on protective responses against solid tumors
Thesis Member
Neidy Rodrigues (PhD)
2018 “Modulation of the haematopoietic stem cell niche by photo-triggerable nanoparticles” - Emanuel Quartin Costa
(Thesis) Main arguer
Emanuel Quartin Costa (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 “Study of the impact of IL7R gain-of-function mutation on in vivo leukemogenesis” - Tiago Soares (Supervisor)
Supervisor
Tiago Soares - Msc. student (Master)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade do Algarve - Campus de Gambelas, Portugal
2018 “Co-transcriptional quality control of mRNA biogenesis: impact for human genetic diseases” - Rita Vaz Drago
(Thesis) Arguer
Rita Vaz Drago (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017 “How the RPL10 R98S mutation translates T-Cell acute lymphoblastic leukemia” - Tiziana Girardi
(Thesis) Main arguer
Tiziana Girardi (PhD)
Katholieke Universiteit Leuven Centrum voor Biomedische Ethiek en Recht, Belgium
2017 “Therapeutic targeting of CNS hemangioblastomas in VHL disease” - Ana Marguerita Metelo
(Thesis) Arguer
Ana Marguerita Metelo (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 “The functional crosstalk of proteolytic systems and metabolism in acute myeloid leukemia” - Ângela Fernandes
(Thesis) Arguer
Ângela Fernandes (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 “Molecular mechanisms controlling the survival and differentiation of human ¿d thymocytes” - Sérgio Ribeiro
(Thesis) Arguer
Sérgio Ribeiro (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017 “Role of PLC¿1 in the resistance mechanism to anti-EGFR therapy in metastatic colorectal cancer” - Raquel Duarte
(Thesis) Main arguer
Raquel Duarte (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016 “Dissecting the Cellular and Molecular Mechanisms of IL-7-mediated Leukemia T- cell Survival, Proliferation and Cell Growth” - Daniel Ribeiro (Supervisor)
Supervisor
Daniel Ribeiro (PhD)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2016 “The role of Myogenic Regulatory Factors in Rhabdomyosarcoma: insights from zebrafish and beyond” - Inês Tenente
(Thesis) Main arguer
Inês Tenente (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 “Does hyperglycemia impact the crosstalk between AML cells and BM stroma? - The role of CXCL12/CXCR4 chemoattraction axis” - Ana Catarina Martins
(Thesis) Main arguer
Ana Catarina Martins (Master)
Universidade do Minho Escola de Medicina, Portugal
2015 “Seeking new insights into IL-7Ra mutational activation in T-cell leukemia” - Joana Silva (Supervisor)
Supervisor
Joana Silva (Master)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 “Determining the prognostic significance of PI3K/Akt/mTOR and JAK/STAT5 signaling pathways in pediatric acute lymphoblastic leukemia using single-cell analysis” - Mariana L. Oliveira (Supervisor)
Supervisor
Mariana L. Oliveira (Master)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2015 “The role of reciprocal regulation between TAL1 and miRNA expression in T-cell leukemia progression” - Nádia Correia (Supervisor)
Supervisor
Nádia Correia (PhD)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2014 “Long Non-coding RNAs at the Service of p53” - Carlos Melo
(Thesis) Main arguer
Carlos Melo (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014 “Stochasticity and commitment in monoallelic gene activation” - Clara Pereira
(Thesis) Arguer
Clara Pereira (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014 “The role of sphingosine kinase in IL-7-mediated signaling and T-cell acute lymphoblastic leukemia” - Joana Matos (Supervisor)
Supervisor
Joana Matos (Master)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2014 “Maintaining the balance: Novel molecular mechanisms regulating Foxp3 function” - Xavier Cahu (evaluated the thesis and wrote his formal evaluation of the thesis but did not participate in the thesis defense for health reasons).
(Thesis) Main arguer
Xavier Cahu (PhD)
Université de Paris, France
2014 “Maintaining the balance: Novel molecular mechanisms regulating Foxp3 function”. - Veerle Fleskens
(Thesis) Main arguer
Veerle Fleskens (PhD)
Universiteit Utrecht, Netherlands
2014 “Dissecting the signaling mechanisms of IL-7-mediated autophagy regulation in T-cell acute lymphoblastic leukemia” - Maria Inês Felizardo Lopes (Supervisor)
Supervisor
Maria Inês Felizardo Lopes (Master)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2014 “On the reprogramming of the Krebs cycle in hypoxic and VHL-deficient cancer cells” - Paulo A. Gameiro
(Thesis) Main arguer
Paulo A. Gameiro (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014 “Resveratrol-induced activation of the Sirt1/AMPK axis in human CD4 T cells triggers replicative stress and na ATR-dependent cell cycle arrest” - Marco Filipe Craveiro
(Thesis) Main arguer
Marco Filipe Craveiro (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013 “Autophagy and inflammasome: how are they related?” - Maria Inês Mahú
(Thesis) Main arguer
Maria Inês Mahú (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013 “HIF & CHIPs: A new autophagic pathway for the degradation of HIF-1a” - João Vasco Ferreira
(Thesis) Main arguer
João Vasco Ferreira (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013 “¿d T cell responses to tumours: recruitment, recognition and functions” - Telma Lança
(Thesis) Arguer
Telma Lança (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2012 “B cells at the crossroad of immune responses: insights from primary B-cell immunodeficiencies” - Rita Barbosa
(Thesis) Arguer
Rita Barbosa (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2012 “The T cell surface glycoprotein CD5: a regulatory hub in T cell signaling” - Ana Mafalda Santos
(Thesis) Main arguer
Ana Mafalda Santos (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012 “The role of SETD2 in transcription and in DNA damage response” - Sílvia Carvalho
(Thesis) Main arguer
Sílvia Carvalho (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012 “Protein tyrosine kinase signaling in T-cell acute lymphoblastic leukemia”. - Michaël Porcu
(Thesis) Main arguer
Michaël Porcu (PhD)
Katholieke Universiteit Leuven Departement Cellulaire en Moleculaire Geneeskunde, Belgium
2012 “Modulating hematopoietic progenitor cell engraftment and T cell differentiation: Role of conditioning and route of administration” - Stéphanie de Barros
(Thesis) Main arguer
Stéphanie de Barros (PhD)
Université de Montpellier, France
2012 “CK2 as a potential novel therapeutic target in chronic lymphocytic leukemia” - Leila Martins (Supervisor)
Supervisor
Leila Martins (PhD)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2012 “HIV2 immunopathology: how the immune system deals with long-lasting infection” - Rita Tendeiro
(Thesis) Arguer
Rita Tendeiro (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2012 “The transcriptome of the oncogenic HOXA9 homeoprotein in human glioblastomas: functional and clinical relevance” - Ana Xavier Magalhães
(Thesis) Main arguer
Ana Xavier Magalhães (Master)
Universidade do Minho Escola de Ciências, Portugal
2012 “The role of the delta-like 4 Notch ligand in tumor angiogenesis” - Dusan Djokovic
(Thesis) Arguer
Dusan Djokovic (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2012 “Lentiviral target-specific strategy for molecular therapy” - Lídia Fonseca
(Thesis) Arguer
Lídia Fonseca (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 “Molecular mechanisms of human ¿¿ T cell activation and tumor cell recognition” - Daniel Correia
(Thesis) Arguer
Daniel Correia (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2012 “Identification of mechanisms controlling the transcriptional activity of nuclear factor kappa B (NF-kB) p65/RelA” - Nadja Pejanovic
(Thesis) Arguer
Nadja Pejanovic (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011 “IL-4 and TAL1 in T-cell acute lymphoblastic leukemia: studies on the participation of microenvironmental cues and cell-autonomous alterations in leukemogenesis” - Bruno Cardoso (Supervisor)
Supervisor
Bruno Cardoso (PhD)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2011 “RTKs and MAPK pathway alterations in solid tumors: dissecting prognostic and therapeutic biomarkers” - Olga Martinho
(Thesis) Main arguer
Olga Martinho (PhD)
Universidade do Minho Escola de Ciências, Portugal
2011 “Estudo da regulação da angiogénese tumoral pelo H2O2 in vivo [Study of tumor angiogenesis regulation by H2O2 in vivo]” - Gonçalo Rodrigues
(Thesis) Main arguer
Gonçalo Rodrigues (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 “The Role of Lymphotoxin-¿ Receptor Signaling in T-cell Acute Lymphoblastic Leukemia Development” - Mónica Fernandes
(Thesis) Main arguer
Mónica Fernandes (Master)
Universidade do Algarve - Campus de Gambelas, Portugal
2010 “Development of regulatory T cells in human thymus: one step beyond” - Helena Cabaço
(Thesis) Arguer
Helena Cabaço (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2010 “Analysis of PAX2 gene alterations in renal cell tumors” - Patrícia Patrício
(Thesis) Main arguer
Patrícia Patrício (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010 “Genetic dissection of antigen presentation pathways” - Catarina Ferreira Moita
(Thesis) Arguer
Catarina Ferreira Moita (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2010 “Biochemical and functional analysis of the T cell growth and survival bioactivities of human red blood cells” - Ricardo Filipe Antunes
(Thesis) Main arguer
Ricardo Filipe Antunes (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010 “The regulation of interleukin 7 receptor alpha internalization, recycling and degradation by IL-7 – possible implications in T-cell homeostasis, migration and leukaemogenesis” - Catarina Henriques (Supervisor)
Supervisor
Catarina Henriques (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal

Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2010 “IL-7- and PI3K-Mediated Signaling in T-Cell Leukemia: The Role of External and Cell-Autonomous Signals in Tumorigenesis” - Ana Silva (Supervisor)
Supervisor
Ana Silva (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal

Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2009 “Studies on a human model and a murine model of immunodeficiency: HIV-2 infection and TACI deficiency”. - Catarina Cortesão
(Thesis) Arguer
Catarina Cortesão (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2009 “The role and therapeutic potential of regulators and effectors of PI3K/Akt pathway in T-cell leukemia” - Daniel Ribeiro (Supervisor)
Supervisor
Daniel Ribeiro (Master)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
2009 “Screening for RAG activity in haematopoietic tumours using a novel reporter strategy” - Inês Trancoso
(Thesis) Main arguer
Inês Trancoso (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 “Targeted Gene Silencing Therapy in Small Cell Lung Cancer” - Adriana Oliveira dos Santos
(Thesis) Main arguer
Adriana Oliveira dos Santos (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2009 “Topoisomerase-II mediated DNA damage: role of BRCA1 and other chromatin structure regulators” - Inês Teles Alves
(Thesis) Main arguer
Inês Teles Alves (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 “Genetic and functional analysis of IL-7 signalling in control of T cell homeostasis” - Claire Pearson
(Thesis) Main arguer
Claire Pearson (PhD)
National Institute for Medical Research, United Kingdom
2009 “Signalling Pathways Activated by Red Blood Cells-Derived Factors in Normal T cells and Jurkat T cells” - Cláudia Brandão Silva
(Thesis) Main arguer
Cláudia Brandão Silva (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2008 Ultrasound contrast agents in triggered drug and gene delivery” - Marta Aido
(Thesis) Main arguer
Marta Aido (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 “Lentiviral target-specific strategy for molecular therapy” - Lídia Fonseca (1st Year PhD Final Report)
(Thesis) Main arguer
Lídia Fonseca (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 “Identification and Characterization of Novel Molecular Components of the mTOR Complexes”. - Maria Alexandra Frias
(Thesis) Main arguer
Maria Alexandra Frias (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2008 “Characterization of an In vitro 3D Multicellular Model of the Tumor Microenvironment” - Pedro Sampaio
(Thesis) Main arguer
Pedro Sampaio (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2008 “Estudo do Efeito da Activação da Cascata de Sinalização JAK/STAT por IL-7 em Células T Malignas [Study of the effect of the activation of JAK/STAT signaling pathway by IL-7 in malignant T cells]” - Cristina Santos (Supervisor)
Supervisor
Cristina Santos (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2005 “Clonagem dos genes tal1 e lmo2 num vector lentiviral para expressão em células T precursoras primárias [Cloning of tal1 and lmo2 in a lentiviral vector for expression in primary precursor T cells]” - Bruno Cardoso (Supervisor)
Supervisor
Bruno Cardoso - Bsc. student (Other)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
2004 “IL-7-mediated signaling in human thymocytes” - Luís Bicheiro (Supervisor)
Supervisor
Luís Bicheiro - Bsc. student (Other)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
2004 “Efeito da Activação da Cascata de Sinalização Jak/STAT por IL-7 em Células T Leucémicas [Effect of IL-7-mediated Jak/STAT pathway activation on leukemic T cells]” - Luís Vinagre (Supervisor)
Supervisor
Luís Vinagre - Bsc. student (Other)
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2015 - Current Associação Portuguesa de Investigação em Cancro (ASPIC) – Portuguese Association for Cancer Research
2010 - Current Sociedade Portuguesa de Imunologia (SPI) – Portuguese Society of Immunology
2006 - Current Sociedade Portuguesa de Ciências em Pequenos Animais de Laboratório (SPCAL) – Portuguese Society of Sciences in Small Laboratory Animals
2005 - Current European Association for Cancer Research (EACR)
2004 - Current Sociedade Portuguesa de Bioquímica (SPB) – Portuguese Society of Biochemistry
2001 - Current Society for Hematology and Stem Cells – former International Society for Experimental Hematology (ISEH)
1996 - Current Sociedade Portuguesa de Autores (SPA) – Portuguese Authors Society
1992 - Current Ordem dos Biólogos (Obio) – Order of the Portuguese Biologists
1998 - 2002 Portuguese-American Post-graduate Society (PAPS)
1994 - 1995 Co-director of the Marketing Section, Board of European Students of Technology, Coimbra, Portugal

Committee member

Activity description
Role
Institution / Organization
2022 - Current Member of the LIFE SCIENCES 1 Evaluator Panel Committee for the “la Caixa” Foundation Postgraduate Abroad Fellowships Programme 2022, Spain
Member
2022 - Current Member of the Reviewer Group for "Category 603 - Lymphoid Oncogenesis: Basic" of the 64th Annual Meeting of the American Society of Hematology, USA
Member
2022 - Current Member of the Jury for the Prémio GAPIC David Ferreira 2021/2022 Award for the best integrated Masters work done by final year medical students in the Faculty of Medicine of Lisbon University, Portugal
Member
2018 - Current Member of the Scientific Advisory Committee of Worldwide Cancer Research (formerly known as Association for International Cancer Research), UK
Advisor / Consultant
Worldwide Cancer Research, United Kingdom
2021 - 2022 Member of the Grant Evaluation Committee for the "Immunology & Infectious Diseases" program
Member
Agence nationale de la recherche, France
2020 - 2022 Chairman of the General Assembly of the ASPIC (Portuguese Association for Cancer Research).
2018 - 2020 Board Member, ASPIC (Portuguese Association for Cancer Research).
Member
Associação Portuguesa de Investigação em Cancro, Portugal
2018/05/23 - 2018/05/25 Member of the Evaluation Committee for the best oral presentation, XII PhD Students Meetings - Lisbon Academic Medical Center, Lisboa, Portugal, 23-25 May.
Member
2018/05/10 - 2018/05/11 Chairman of the Scientific Committee and co-chair of the EACR and ASEICA plenary lecture session, 3rd ASPIC International Congress, Lisboa, Portugal, 10-11 May.
President / Vice-president
2017 - 2018 Oncobiology Thematic Line Coordinator for the FCT 2017-18 institutional plurennial funding national call (Avaliação de Unidades I&D 2017/2018).
Coordinator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2016 - 2018 Chairman of the General Assembly of the ASPIC (Portuguese Association for Cancer Research).
President / Vice-president
2016 - 2018 Researchers representative at the General Assembly of Instituto de Medicina Molecular.
Coordinator
2013 - 2013 Member of the Selection Committee, LisbonBioMed International FCT PhD Program in Biomedicine and Clinical Research, IMM, Faculty of Medicine of Lisbon University, Lisbon, Portugal.
Member
2012 - 2013 Member of the work group (Strategic Committee), together with Luísa Figueiredo and Henrique Veiga-Fernandes (chair), responsible for the elaboration of the strategic plan in iMM’s application to the FCT 2013 institutional plurennial funding national call (Avaliação de Unidades I&D 2013).
Member
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
1992 - 1993 Member of the National Committee of Students of Biology, Portugal
Member
1992 - 1993 Member of the Pedagogic Council, Faculty of Sciences and Technology, University of Coimbra, Portugal
Member

Conference scientific committee

Conference name Conference host
2020/03/02 - 2020/03/04 EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microevironment
2019/10/18 - 2019/10/19 SINAL 2019 - Xth Meeting on Signal Transduction
2017 - 2017 YoungEHA Research Meeting on Molecular Aspects of Hematological Disorders, Madrid, Spain European Hematology Association
2014/11/25 - 2014/11/26 1st ASPIC International Congress
2013/12/06 - 2013/12/07 SINAL 2013 – 7th National Meeting on Cell Signalling
2012/04/13 - 2012/04/14 SINAL 2012 – 6th National Meeting on Cell Signaling
2011/04/28 - 2011/04/30 SINAL 2011 – 5th Annual Meeting on Cell Signalling
2010/05/21 - 2010/05/22 SINAL 2010 – 4th National Meeting on Signal Transduction

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/02/15 - Current Teacher of the Lab Seminar “Signaling in Cancer: an overview of our work”, LisbonBioMed PhD program, IMM, Faculty of Medicine of Lisbon University, Lisbon, Portugal, 15 February
2021/10/26 - Current Teacher of the Seminar “Signal transduction in cancer: towards precision medicine”, Signal transduction and targeted therapy, Integrated Masters in Medicine (6th year) Seminar “Signal transduction in cancer: towards precision medicine”, Integrated Masters in Medicine (6th year) (Mestrado integrado) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020 - Current Chair of the Oncobiology course for 3rd year medical students (Faculdade de Medicina, Universidade de Lisboa).
2020 - Current Coordinator of the Masters in Oncobiology (Faculdade de Medicina, Universidade de Lisboa)
2015 - Current Teacher (coordinator) of the “Signal Transduction in Cancer” Course of the Masters in Oncobiology, Faculty of Medicine of Lisbon University, Lisbon Academic Medical Center (CAML), Lisbon, Portugal, 14-17 January. Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - Current Teacher at the Oncobiology Course, Signal Transduction in Cancer, Integrated Masters in Medicine (3rd year students), Faculty of Medicine of Lisbon University, Lisbon, Portugal. Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - Current Teacher at and coordinator of (together with Sérgio Dias and Gonçalo Bernardes) the “Tissues and Tumors” week, LisbonBioMed International FCT PhD Program, IMM, Faculty of Medicine of Lisbon University, Lisbon, Portugal. Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2022/03/26 - 2022/03/26 Lecture at "Twists and turns of immune cells: Lymphoid leukemia and anti-leukemia immunotherapies", Curso de Imunologia e Imunoterapia [Immunology and Immunotherapy course], SPFCS - Sociedade Portuguesa dos Farmacêuticos dos Cuidados da Saúde, Tomar, Portugal, 26 March Curso de Imunologia e Imunoterapia
2022/02/15 - 2022/02/15 Teacher of the Lab Seminar “Signaling in Cancer: an overview of our work”, LisbonBioMed PhD program, IMM, Faculty of Medicine of Lisbon University, Lisbon, Portugal.
2021/10/26 - 2021/10/26 Teacher of the Seminar “Signal transduction in cancer: towards precision medicine”, Integrated Masters in Medicine (6th year students), Instituto de Investigação em Ciências da Vida e Saúde (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.
2021/07 - 2021/07 Lecture at “Bridging – A integração da investigação básica na investigação clínica em Oncologia [Bridging – Integrating basic research into Clinical research in Oncology]”, 3ª Edição do Curso de Investigação em Oncologia [3rd Edition of the Course on Research in Oncology], organized by Núcleo de Internos e Jovens Especialistas da SPO [Group of Interns and Young Specialists of the Portuguese Society of Oncology] (Online course)
2019 - 2019 Teacher of the 'Signal Transduction in Cancer' seminar, Molecular and Cellular Biology of Cancer course, Masters in Molecular Biology and Genetics/ Masters in the Biology of Evolution and Development, Faculty of Sciences of the University of Lisbon, Portugal, 11 March. Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2018 Teacher at the Advanced Course on “Fundamentals of Genetics, Development and Neoplasia” (October 22- November 9), International Postgraduate Programme, School of Health Sciences, University of Minho, Braga, Portugal, 23 October. Universidade do Minho Escola de Ciências, Portugal
2017 - 2017 Teacher at the Advanced Course on “Fundamentals of Genetics, Development and Neoplasia” (October 23- November 10), International Postgraduate Programme, School of Health Sciences, University of Minho, Braga, Portugal, 25 October. Universidade do Minho Escola de Ciências, Portugal
2017 - 2017 Teacher of the “Signal Transduction in Cancer” seminar, Molecular and Cellular Biology of Cancer course, Masters in Molecular Biology and Genetics/ Masters in the Biology of Evolution and Development, Faculty of Sciences of the University of Lisbon, Portugal, 6 March. Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2016 Teacher at the Advanced Course on “Fundamentals of Genetics, Development and Neoplasia” (October 24- November 11), International Postgraduate Programme, School of Health Sciences, University of Minho, Braga, Portugal, 27 October. Universidade do Minho Escola de Ciências, Portugal
2016 - 2016 Teacher at the Curricular unit “From the clinics to molecular biology”, Signal transduction and targeted therapy, Integrated Masters in Medicine (6th year students), Instituto de Investigação em Ciências da Vida e Saúde (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, 27 October. Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015 - 2015 Teacher at the Advanced Course on “Fundamentals of Genetics, Development and Neoplasia” (October 12-23), International Postgraduate Programme, School of Health Sciences, University of Minho, Braga, Portugal. Universidade do Minho Escola de Ciências, Portugal
2014 - 2014 Teacher at the Advanced Course on Molecular Oncology: Cancer Biology and Emerging Therapies. Lecture on “Cell cycle & checkpoints – I (G1/S)”. Instituto Português de Oncologia de Coimbra Francisco Gentil, Coimbra, Portugal. 24 October. Instituto Português de Oncologia de Coimbra Francisco Gentil EPE, Portugal
2013 - 2013 Teacher at the Advanced Course on “Fundamentals of Genetics, Development and Neoplasia” (4th Edition, January 14-25; and 5th Edition, October 14-25), International Postgraduate Programme, School of Health Sciences, University of Minho, Braga, Portugal. Universidade do Minho Escola de Ciências, Portugal
2013 - 2013 Teacher (coordinator) of the “Signal Transduction in Cancer” Course of the Masters in Oncobiology, Faculty of Medicine of Lisbon University, Lisbon Academic Medical Center (CAML), Lisbon, Portugal, 15-18 January. Universidade de Lisboa Faculdade de Medicina, Portugal
2008 - 2013 Teacher at the Advanced Course on Oncobiology of the BEB PhD Program of the Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012 - 2012 Teacher at the Workshop on “Imunoterapia do Cancro: da Investigação Básica à Aplicação Clínica [Immunotherapy of Cancer: From Basic Research to Clinical Application]”, Center for Evidence-based Medical Studies (CEMBE), Faculty of Medicine of Lisbon University, Lisbon, Portugal, 24 March. Universidade de Lisboa Faculdade de Medicina, Portugal
2010 - 2010 Teacher at the Advanced Course on “Fundamentals of Genetics, Development and Neoplasia” (October 11-22), International Postgraduate Programme, School of Health Sciences, University of Minho, Braga, Portugal. Universidade do Minho Escola de Ciências, Portugal
2010 - 2010 Teacher of the Module of Cancer Immunotherapy (July 2-3), Curricular unit of Immunological Therapies, Masters in Molecular Therapies, CESPU, Gandra, Portugal. Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2009 - 2010 Teacher (and organizer) at the Cancer Course for the IMM International PhD Program. Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2008 - 2008 Teacher (coordinator) of the discipline “Cancerigenesis”, Masters in Medical Biochemistry, Molecular Biology and Genetics, and Human Molecular Biology, FCUL. Universidade de Lisboa Faculdade de Ciências, Portugal
2002 - 2005 Teacher of the Module “Tumors of the Immune System: Proliferation, Differentiation and Signal Transduction” Masters in Clinical Immunology, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal. Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2019 - Current Reviewer/Evaluator of grant applications/research projects for INSERM.
Evaluator
INSERM, France
2023 - 2023 Reviewer/Evaluator of grant applications/research projects for the Italian Association for Cancer Research ¿ AIRC (Italy).
Evaluator
Associazione Italiana per la Ricerca sul Cancro, Italy
2022 - 2022 Reviewer/Evaluator of grant applications/research projects for the Italian Association for Cancer Research ¿ AIRC (Italy).
Evaluator
Associazione Italiana per la Ricerca sul Cancro, Italy
2021 - 2022 Reviewer/Evaluator of grant applications/research projects for the Italian Association for Cancer Research - AIRC (Italy). Associazione Italiana per la Ricerca sul Cancro, Italy
2021 - 2021 Reviewer/Evaluator of grant applications/research projects for the Institut Pasteur. Institut Pasteur, France
2021 - 2021 Reviewer/Evaluator of grant applications/research projects for the Italian Association for Cancer Research ¿ AIRC (Italy).
Evaluator
Associazione Italiana per la Ricerca sul Cancro, Italy
2021 - 2021 Reviewer/Evaluator of grant applications/research projects for Institute Pasteur
Evaluator
Institut Pasteur, France
2018 - 2018 Reviewer/Evaluator of grant applications/research projects for European Hematology Association
Evaluator
European Hematology Association, Netherlands
2018 - 2018 Reviewer/Evaluator of grant applications/research projects for the KU Leuven (Belgium).
Evaluator
2014 - 2018 Reviewer/Evaluator of grant applications/research projects for the Worldwide Cancer Research (WCR) (formerly known as Association for International Cancer Research – AICR)
Evaluator
Worldwide Cancer Research, United Kingdom
2017/05/24 - 2017/05/26 Member of the evaluation panel of Oral Sessions VI and VII, May 15; XI PhD CAML Students Meeting, iMM-Lisboa, Faculdade de Medicina, Universidade de Lisboa, Portugal, 24-26 May.
Evaluator
2017 - 2017 Reviewer/Evaluator of grant applications/research projects for the European Commission Research Executive Agency - ECREA (Marie Sklodowska-Curie Individual Fellowships)
Evaluator
European Commission Research Executive Agency , Belgium
2017 - 2017 Reviewer/Evaluator of grant applications/research projects for the Dutch Arthritis Association (The Netherlands)
Evaluator
Dutch Arthritis Association , Netherlands
2017 - 2017 Reviewer/Evaluator of grant applications/research projects for the National Science Centre - NCN (Poland).
Evaluator
Narodowe Centrum Nauki, Poland
2016/12/14 - 2016/12/14 Member of the evaluation panel of the Poster Sessions; Research Day for Medical Students / 19th Workshop “Education through Science”, Faculdade de Medicina, Universidade de Lisboa, Portugal, 14 December.
Evaluator
2016 - 2016 Evaluator of grant applications/research projects for the European Research Council - ERC
Evaluator
European Research Council, Belgium
2016 - 2016 Reviewer/Evaluator of grant applications/research projects for the University Medical Center Utrecht (The Netherlands) University Medical Center Utrecht (The Netherlands) , Netherlands
2016 - 2016 Reviewer/Evaluator of grant applications/research projects for the Flanders Research Foundation – FWO (Belgium).
Evaluator
2016 - 2016 Reviewer/Evaluator of grant applications/research projects for the Ministry for Education, University and Research – MIUR (Italy).
Evaluator
Ministero dell'Istruzione dell'Università e della Ricerca, Italy
2016 - 2016 Reviewer/Evaluator of grant applications/research projects for the German Research Foundation/Deutsche Forschungsgemeinschaft – DFG (Germany).
Evaluator
Deutsche Forschungsgemeinschaft, Germany
2011 - 2016 Reviewer/Evaluator of grant applications/research projects for the Fundação para a Ciência e a Tecnologia - FCT (Portugal)
Evaluator
Fundação para a Ciência e a Tecnologia, Portugal
2015/12/16 - 2015/12/16 Member of the evaluation panels of the Poster and Oral communication Sessions; Research Day for Medical Students / 18th Workshop “Education through Science”, Faculdade de Medicina da Universidade de Lisboa, Portugal, 16 December.
Evaluator
2015/11/24 - 2015/11/24 Member of the Evaluation Committee for the renewal of the Specialist Programme “Developmental origins, clonal evolution and molecular targets in childhood acute lymphoblastic leukaemia” (PI: Tariq Enver) funded by Bloodwise (former Leukaemia & Lymphoma Research), University College London, 24 November.
Member
2015/09/25 - 2015/09/25 Member of the Evaluation Committee for the best oral presentation, 3rd iMM Post-Doc Day, Lisboa, Portugal, 25 September.
Member
2015 - 2015 Reviewer/Evaluator of grant applications/research projects for the Italian Association for Cancer Research – AIRC (Italy).
Evaluator
Associazione Italiana per la Ricerca sul Cancro, Italy
2012 - 2015 Reviewer/Evaluator of grant applications/research projects for the Bloodwise (formerly known as Leukaemia & Lymphoma Research (UK).
Evaluator
Bloodwise, United Kingdom
2014 - 2014 Reviewer/Evaluator of grant applications/research projects for the Foundation Against Cancer (Belgium).
Evaluator
Fondation contre le Cancer, Belgium
2013/12/11 - 2013/12/11 Member of the evaluation panel, Poster Session II; Research Day for Medical Students / 16th Workshop “Education through Science”, Faculdade de Medicina da Universidade de Lisboa, Portugal, 11 December.
Evaluator
2013 - 2013 Reviewer/Evaluator of grant applications/research projects for the KU Leuven (Belgium).
Evaluator
2013 - 2013 Reviewer/Evaluator of grant applications/research projects for the Flemish League against Cancer – VLK (Belgium).
Evaluator
2013 - 2013 Reviewer/Evaluator of grant applications/research projects for the Wellcome Trust/DBT India Alliance (India).
Evaluator
2012 - 2013 Reviewer/Evaluator of grant applications/research projects for the National Agency for the Evaluation of Universities and Research Institutes – ANVUR (Italy)
Evaluator
2012 - 2012 Reviewer/Evaluator of grant applications/research projects for European Hematology Association.
Evaluator
European Hematology Association, Netherlands
2012 - 2012 Reviewer/Evaluator of grant applications/research projects for the Flanders Research Foundation – FWO (Belgium).
Evaluator
2012 - 2012 Reviewer/Evaluator of grant applications/research projects for the Fondazione Cassa di Risparmio di Padova e Rovigo - CARIPARO.
Evaluator
Fondazione Cassa di Risparmio di Padova e Rovigo, Italy
2012 - 2012 Reviewer/Evaluator of grant applications/research projects for the Italian Association for Cancer Research – AIRC (Italy).
Evaluator
Associazione Italiana per la Ricerca sul Cancro, Italy
2011/11/29 - 2011/11/30 Member of the Jury for the selection of the best poster “Portrait of the Immune System: History and Perspective” XXXVII Annual Meeting of the Portuguese Society of Immunology, Instituto Gulbenkian de Ciência, Oeiras, Portugal, 29-30 November.
Member
Sociedade Portuguesa de Imunologia, Portugal
2011 - 2011 Reviewer/Evaluator of grant applications/research projects for the Faculty of Medicine of the University of Coimbra (Portugal).
Evaluator
Universidade de Coimbra Faculdade de Medicina, Portugal
2010 - 2010 Reviewer/Evaluator of grant applications/research projects for the Dutch Cancer Society (The Netherlands).
Evaluator
KWF Kankerbestrijding, Netherlands
2010 - 2010 Reviewer/Evaluator of grant applications/research projects for the Health Research Board (Ireland).
Evaluator
Health Research Board, Ireland
2009/10/12 - 2009/10/13 Member of the Jury for the selection of the best poster and oral communications, 3rd IMM PhD Students Meeting, IMM, Lisbon, Portugal, 12-13 October.
Evaluator
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2008 - 2008 Reviewer/Evaluator of grant applications/research projects for Dutch Arthritis Association (The Netherlands).
Evaluator
Dutch Arthritis Association , Netherlands
2008 - 2008 Member of evaluation committees of the applications for the positions open under the protocol “Ciência 2008” at IPATIMUP, Porto, Portugal, and Life and Health Science Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.
Member
Fundação para a Ciência e a Tecnologia, Portugal
2007 - 2007 Reviewer/Evaluator of grant applications/research projects for the Centro Infantil Boldrini (Brazil).
Evaluator

Journal scientific committee

Journal title (ISSN) Publisher
2023 - Current Leukemia (1476-5551) Springer Nature
2022 - Current Tumor Discovery (2810-9775) ACC Science Publishing
2020 - Current Cancers (2072-6694) MDPI AG
2018/11 - Current Cells (2073-4409) MDPI
2016 - Current Cellular Signalling
2011/10 - Current American Journal of Cancer Research (2156-6976) e-Century Publishing

Mentoring / Tutoring

Topic Student name
2024 - Current Mentor/ Tutor of Margarida Paulo Pedro (Supervisors: Ana E. Sousa and Afonso Almeida) Margarida Paulo Pedro
2023 - Current Mentor/ Tutor of Carolina Pinto (Supervisor: Vera Martins) Carolina Pinto
2021 - Current Mentor/ Tutor of Raquel Sofia Cruz-Duarte (Supervisor: Marta Martins) Raquel Sofia Cruz-Duarte
2021 - Current Mentor/ Tutor of Ítala Silva (Supervisors: Sónia Gonçalves e Nuno Santos). Ítala Silva
2016 - Current Carlos Labão-Almeida (Supervisors: Gonçalo Bernardes & Karine Serre)
2014 - Current Rui Traquete (Supervisor: Gonçalo Bernardes)
2017 - 2022 Marco Cavaco (Supervisor: Miguel Castanho)
2015 - 2022 Mentor/ Tutor of Catarina Silveira (Supervisor: Maria Carmo-Fonseca) Catarina Silveira
2015 - 2018 Vânia Cardoso (Supervisor: Henrique Veiga-Fernandes)
2014 - 2018 Susana Lopes da Silva (Supervisor: Ana Espada Sousa)
2013 - 2018 Neidy Rodrigues (Supervisors: Sérgio Dias e Bruno Silva-Santos)
2013 - 2018 Rita Drago (Supervisor: Carmo-Fonseca)
2016 - 2017 Yumie Tokunaga (Supervisor: Ana Espada Sousa - ENLIGHTEN)
2009 - 2017 Pedro Didelet Pereira (Supervisor: João Ferreira)
2012 - 2016 Diana Fontinha (Supervisor: Pedro Simas)
2012 - 2016 Francisco Aresta Branco (Supervisor: Luísa Figueiredo)
2011 - 2015 Mónica Fernandes (Supervisor: Nuno Rodrigues dos Santos – Universidade do Algarve)
2010 - 2015 Catarina Moita Silva (Supervisor: Íris Caramalho)
2010 - 2014 Vânia Batalha (Supervisor: Luísa Lopes)
2009 - 2014 Carolina Moreira (Supervisor: Soren Prag)
2008 - 2013 Diogo Pereira (Supervisor: Henrique Veiga-Fernandes)
2008 - 2013 Leonor Miller Fleming (Supervisor: Tiago Outeiro)
2008 - 2012 Sofia Azevedo (Supervisor: Leonor Saúde)
2007 - 2012 Ana de Barros
2007 - 2012 Ana de Barros (Supervisor: Bruno Silva-Santos)
2008 - 2011 Olga Martinho (Supervisor: Rui Reis - Universidade do Minho)
2005 - 2011 Inês Sofia Vala (Supervisor: Susana Constantino)

Other jury / evaluation

Activity description Institution / Organization
2022 - Current Reviewer for the international journals Advances in Biological Regulation, British Journal of Haematology and Expert Opinion On Therapeutic Targets (2022).
2021 - Current Reviewer for the international journal Redox Biology and Review Commons
2019 - Current Guest Editor, Advances in Biological Regulation special issue on “T-cell acute lymphoblastic leukemia genetics, biology and therapeutics” (2019).
2016/09 - Current Editorial Board member of Cellular Signalling (from September 2016), Cells (from November 2018), and Cancers (from April 2020). Associate Editor of the American Journal of Cancer Research (from October 2011) and of Tumor Discovery (from September 2022). Ad Hoc Section Editor for Leukemia.
2012 - Current Reviewer for the international journals Molecular and Cellular Biology, Mediators of Inflammation, Molecular Pharmaceutics, Oncotarget, OncoTargets and Therapy, Pediatric Blood & Cancer, PLoS One, Scientific Reports, Seminars in Cell & Developmental Biology, Signals, Translational Oncology, and Tumor Biology.
2010 - Current Reviewer for the international journals Haematologica, HemaSphere, Immunology & Cell Biology, Inflammation Research, International Journal of Molecular Sciences, Journal of Immunological Methods, Journal of Immunology, Journal of Leukocyte Biology, Leukemia & Lymphoma and Leukemia Research,
2008 - Current Reviewer for the international journals Nature Medicine, Nature Communications, Science Translational Medicine, EMBO Molecular Medicine, Journal of Clinical Investigation, Blood, Leukemia, Oncogene, as well as: Advances in Hematology, African Journal of Biotechnology, Annals of Hematology, Archives of Medical Research, Biochemical Journal, Blood Cancer Journal, Cancers, Cells, Cell cycle, Cellular and Mollecular Immunology, Cellular Signalling, Cytokine, Drug Design, Development and Therapy, Experimental Hematology and Expert Review of Hematology
Distinctions

Award

2023 Abstract Achievement Award - “Dependence of IL-7R-mediated signaling on sphingosine kinase activity in acute lymphoblastic leukemia, but not healthy lymphoid cells, is an exploitable therapeutic vulnerability” to his PhD student Marta Fernandes
American Society of Hematology, United States
2023 Award for best PhD work in Oncology and Precision Medicine, for the work entitled ¿¿Sphingosine Kinases are essential positive modulators of IL7/IL-7R signaling in Acute Lymphoblastic Leukemia¿¿ to his PhD student Marta Fernandes
Universidade de Lisboa Faculdade de Medicina, Portugal
2023 iMM Best Master Thesis Award, for the work entitled "Histone Deacetylase Inhibitors as therapeutic candidates against IL-7-responsive Acute Lymphoblastic Leukemia" (by J. Fontela, J.T. Barata) to his Master Student João Fontela
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2022 Award for best MSc work in Oncology and Precision Medicine - 'Exploring Exploring the role of HoxA9 in the role of HoxA9 in IL7R-mediated B-Cell Leukemogenesis' (by S. Gama, M. Duque, J.T. Barata) to his Master student Sara Gama
Universidade de Lisboa Faculdade de Medicina, Portugal
2021 Pfizer Award on Basic Research. Sociedade das Ciências Médicas de Lisboa.
2019 Best oral presentation award, for the work entitled “Sphingosine Kinases are key effectors of IL-7R-mediated signaling, viability, growth and proliferation in T-cell Acute Lymphoblastic Leukemia” to his PhD student Marta B. Fernandes
Federation of European Biochemical Societies, United Kingdom
2019 Best poster award, for the work entitled “Sphingosine Kinases are key effectors of IL-7R-mediated signaling, viability, growth and proliferation in T-cell Acute Lymphoblastic Leukemia” to his PhD student Marta B. Fernandes,
SINAL - Signal Transdcution Network, Portugal
2018 Best oral presentation award, for the work entitled “CASZ1 is overexpressed in T-cell acute lymphoblastic leukemia and promotes cell transformation and tumor growth via PI3K-mTOR” to his Post-Doc Bruno A. Cardoso
Associação Portuguesa de Investigação em Cancro, Portugal
2014 Pfizer Award on Clinical Research. Sociedade das Ciências Médicas de Lisboa.
Pfizer Portugal, Portugal
2013 Silver Medal for Distinct Services from the Portuguese Ministry of Health.
Ministério da Saúde, Portugal
2011 Pfizer Award on Clinical Research. Sociedade das Ciências Médicas de Lisboa.
Pfizer Portugal, Portugal
2009 Pulido Valente Science Prize 2009 - Translational Molecular Oncology (Attributed to his student Ana Silva for the published work: Silva, Yunes, Cardoso, Martins, Jotta, Abecasis, Nowill, Leslie, Cardoso & Barata (2008). PTEN Posttranslational Inactivation
Fundação para a Ciência e a Tecnologia, Portugal

Fundação Francisco Pulido Valente, Portugal
2008 Pfizer Award on Basic Research. Sociedade das Ciências Médicas de Lisboa.
Pfizer Portugal, Portugal
2005 Prize “Programa de Apoio à Investigação em Onco-Hematologia”. Associação Portuguesa Contra a Leucemia
Associação Portuguesa Contra a Leucecmia, Portugal
2004 Prize “Programa Gulbenkian de Estímulo à Investigação 2004”. Fundação Calouste Gulbenkian. (Attributed to his student Ana Silva for her PhD project)
Fundação Calouste Gulbenkian, Portugal
2002 LabMED Award – 3rd Place. LabMED Laboratories.
LabMED laboratories, Portugal

Other distinction

2012 Best Immunology Paper Award (Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nature Genetics 43:932.).
Sociedade Portuguesa de Imunologia, Portugal
2011 Vote of congratulations from the Portuguese Parliament recognizing the work conducted by João Barata’s research team.
Assembleia da República, Portugal
2010 NRS/LPCC – “TERRY FOX” Grant/Prize for Research in Oncology
Liga Portuguesa Contra o Cancro Núcleo Regional do Sul, Portugal
2006 Scholarship/travel award. European Commission’s Marie Curie Actions. 1st ESH - AACR Conference on Molecular Basis for Targeted Therapy for Leukaemia (European School of Haematology).
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions, Belgium
2006 Scholarship/travel award. European Commission’s Marie Curie Actions. 6th ESH - UT MD Anderson Cancer Center Interdisciplinary Euroconference on Mechanisms of Cell Death and Disease: Advances in Therapeutic Intervention and Drug Development.
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions, Belgium
2005 EMBO Short Term Fellowship – June – July
European Molecular Biology Laboratory, Germany
2003 Post-Doctoral scholarship from Fundação para a Ciência e a Tecnologia (FCT), Portugal.
Fundação para a Ciência e a Tecnologia, Portugal
2002 Travel Award. The International Society for Experimental Hematology. 31st ISEH Annual Meeting.
The International Society for Experimental Hematology, United States
2002 Travel Award. The American Society of Hematology. 44th ASH Annual Meeting.
The American Society of Hematology, United States
2000 Travel Award. The American Society of Hematology. 42nd ASH Annual Meeting.
The American Society of Hematology, United States
1999 Travel Award. The American Society of Hematology. 41st ASH Annual Meeting.
The American Society of Hematology, United States
1998 Ph.D. scholarship from FCT, Portugal.
Fundação para a Ciência e a Tecnologia, Portugal
1996 M.Sc. scholarship (1st year of the Ph.D. Program on Basic and Applied Biology) from Junta Nacional para a Investigação Científica e Tecnológica (JNICT), Portugal.
Junta Nacional para a Investigação Científica e Tecnológica , Portugal