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Ana Isabel Tomaz is presently an Assistant Professor of the Chemistry and Biochemistry Department of Faculdade de Ciências, ULisboa (Portugal) and an integrated research member at Centro de Química Estrutural - Faculdade de Ciências. She completed her 'Doutoramento' in Chemistry in 2003 by Universidade de Lisboa, Instituto Superior Técnico, and the 'Licenciatura' in Chemical Engineering - Applied Chemistry in 1995 by Universidade Técnica de Lisboa - Instituto Superior Técnico. She works in Exact Sciences with emphasis on Inorganic Chemistry. Her research interests are focused on the development of metallodrugs for therapeutic application, and in the last years her research has been directed to the development of ruthenium-based compounds as prospective cancer chemotherapeutics. Her scientific work to date led to: 70 Papers published in Peer Reviewed International Journals, 3 Book chapters and 5 book chapter sections; 1 International Patent granted; 14 Oral communications (5 Invited) as Speaker in Scientific National/international Conferences and 35 Oral communications (overall) in Scientific National/international Conferences. ------------------------------------------------------------------------------------------------------------------------------- Summary of Scientific Output Indicators || Total indexed publications: 75 (WoS, Core Collection) 61 (Scopus); Hirsch(h)-index: 31 (WoS) 34 (Scopus) || Sum of citations: 2,299 (WoS) 2,359 (Scopus); m-index(WoS): 1.19 (1998-2024).
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Identification

Personal identification

Full name
Ana Isabel Tomaz

Citation names

  • Tomaz, Ana
  • Tomaz, Ana Isabel
  • Tomaz, Isabel

Author identifiers

Ciência ID
B612-C1B4-42AC
ORCID iD
0000-0002-2249-4684
Google Scholar ID
https://goo.gl/15yW46
Researcher Id
HZK-6335-2023
Scopus Author Id
57222121047

Email addresses

  • isabel.tomaz@ciencias.ulisboa.pt (Professional)

Addresses

  • Campo Grande, University Campus - C8 building, 8.5.30, 1749-016, Lisbon, Lisbon, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Inorganic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Elementary (A2)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1)
Education
Degree Classification
2003/07/07
Concluded
 Química (Doutoramento)
Major in Sem especialidade
Centro de Química Estrutural - Instituto Superior Técnico, Portugal
"Complexos de Vanádio (IV) com Ligandos de Interesse Biológico - Vanadium(IV) complexes with ligands of biological interest" (THESIS/DISSERTATION)
1995/06/30
Concluded
 Chemical Engineering - Applied Chemistry (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"na" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2020/03/01 - 2020/10/31 Auxiliary Researcher (Research) FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal
2019/06/01 - 2019/11/30 Auxiliary Researcher (Research) Universidade de Lisboa Centro de Química Estrutural, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2013/12/20 - 2018/12/19 Auxiliary Researcher (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
2009/07/01 - 2013/12/19 Auxiliary Researcher (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
2007/09/01 - 2009/06/30 Postdoc (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
2003/08 - 2007/07 Postdoc (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
(...)

Teaching in Higher Education

Category
Host institution 		Employer
2020/11/04 - Current Assistant Professor (University Teacher) Universidade de Lisboa, Portugal
Faculty of Sciences - University of Lisbon, Portugal
2021/03/01 - 2021/10/31 Invited Assistant Professor (University Teacher) Faculty of Sciences - University of Lisbon, Portugal
Faculty of Sciences - University of Lisbon, Portugal
2013/12/20 - 2018/12/19 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2018 Lecturer (University Teacher) Universidade de Lisboa, Portugal
2013 - 2016 Lecturer (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
2009/07/01 - 2013/12/19 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
Projects

Grant

Designation Funders
2019/06/01 - Current FCT NKFIH 2019/2020 - Development and biospeciation studies of antitumor ruthenium complexes
FCT/NKFIH_2019/2020
Principal investigator
Centro de Química Estrutural - Faculty of Sciences, Portugal
 FCT - Fundação para a Ciência e Tecnologia
Ongoing

Contract

Designation Funders
2013/12/20 - 2018/12/19 Developing the potential of ruthenium complexes in cancer chemotherapy - RuCA
IF/01179/2013/CP1159/CT0002
Principal investigator
Centro de Ciências Moleculares e Materiais - Faculdade de Ciências Universidade de Lisboa, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/07/01 - 2013/12/19 Not available
CONT_DOUT/55/UL/536/9803/ 75/2008
Universidade de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Ruthenium Complexes for Anti-tumour application - RuCAt
PTDC/QUI-QUI/101187/2008
Principal investigator
Centro de Ciências Moleculares e Materiais - Faculdade de Ciências Universidade de Lisboa, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2013 Preclinical evaluation of ruthenium potential drugs for cancer therapy
PTDC/Qui-Qui/118077/2010
PTDC/Qui-Qui/118077/2010
PTDC/QUI-QUI/118077/2010
Researcher
Centro de Ciências Moleculares e Materiais - Faculdade de Ciências Universidade de Lisboa, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2004 - 2007 Development of new vanadium compounds for applications as anti diabetic and anti-cancer agents
POCTI/QUI/56949/2004-PPCDT/QUI/56949/2004
POCI/QUI/56949/2004
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2003/08/01 - 2006/11/30 COMPLEXOS DE VANÁDIO IV E V COM AÇUCARES, NUCLEÓSIDOS, NUCLEOTÍDEOS E DERIVADOS: ESTUDOS DE QUÍMICA DE COORDENAÇÃO E ACTIVIDADE BIOLÓGICA
SFRH/BPD/11536/2002
 Fundação para a Ciência e a Tecnologia
Concluded
2004 - 2005 Insulin-mimetic compounds and structural and functional models of their mechanism of action
Post-doc
Universidade de Lisboa Centro de Química Estrutural, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1999/01/01 - 2002/12/31 SÍNTESE DE COMPLEXOS DE VANÁDIO COM LIGANDOS DE INTERESSE BIOLÓGICO
PRAXIS XXI/BD/18548/98
 Fundação para a Ciência e a Tecnologia
Concluded
1996/07/01 - 1998/12/31 COMPLEXOS DE AMINOÁCIDOS E DERIVADOS - APLICAÇÕES
GGP XXI/BIC/2715/96
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Valente, Andreia; Morais, Tânia S.; Ricardo G. Teixeira; Cristina P. Matos; Garcia, M. Helena; Tomaz, Ana Isabel;. Corresponding author: Tomaz, Ana Isabel;. "Chapter 6 - New Inorganic Therapeutics I : : Ruthenium and iron metallodrugs: new inorganic and organometallic complexes as prospective anticancer agents". In Synthetic Inorganic Chemistry - New perspectives, edited by Ewan J. M. Hamilton. Elsevier, 2021.
    Published
  2. Valente, Andreia; Morais, Tânia S.; Teixeira, Ricardo Jorge Gonçalves; Matos, Cristina P.; Tomaz, Ana Isabel; Garcia, Maria Helena. "Ruthenium and iron metallodrugs: new inorganic and organometallic complexes as prospective anticancer agents". In Chp 7. In Synthetic Inorganic Chemistry. Elsevier, Editor: Ewan Hamilton, 2021.
    Published
  3. Tomaz, Ana Isabel;; Maria Isabel Rodrigues Correia; ISABEL MARIA PALMA ANTUNES CAVACO. Corresponding author: Tomaz, Ana Isabel;. "A colorida beleza e versatilidade do Vanádio". In Os Elementos em Ciências - Uma viagem pela Tabela Periódica, edited by Ana Mourato; Ana Paula Carvalho; Filomena Elisabete Lopes Martins Elvas Leitão; Teresa Pamplona, 79-80. Lisbon, Portugal: Ciências - ULisboa, 2020.
    Published
  4. Matos, A.P.; Mendes, F.; Valente, A.; Morais, T.S.; Tomaz, Ana Isabel; Garcia, M. Helena; Bicho, M.; et al. Corresponding author: Marques, F.. "Ruthenium-based Anticancer Compounds: Insights into their Cellular Targeting and Mechanism of Action in Ruthenium Complexes". In Ruthenium Complexes - Photochemical and Biomedical Applications, edited by Holder, Alvin A.; Bullock Jr., Jimmie L. ; Lawrence, Marc A.; Browne, Wesley R. ; Lilge, Lothar, 201-219. Wiley VCH Verlag, 2018.
    Published • 10.1002/9783527695225.ch10
  5. Valente, A.; Silva, Tiago J.L.; Mendes, Paulo J. G.; Tomaz, Ana Isabel; Garcia, M. Helena; Mendes, Paulo J.; Silva, Tiago JL; Valente, Andreia. "Polymerization of e-Caprolactone Using a Ruthenium(II) Mixed Metallocene Catalyst". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (Chp. 16.5), edited by Afonso, Carlos A M; Candeias, Nuno R; Simão, Dulce Pereira; Trindade, Alexandre F; Coelho, Jaime A S; Tan, Bin; Franzen, Robert, 864-867. Cambridge, United Kingdom: Royal Society of Chemistry, 2017.
    Published
  6. Mendes, Paulo J.; Silva, Tiago J. L.; Garcia, M. Helena; Tomaz, Ana Isabel; Silva, Tiago J.L.; Mendes, Paulo J. G.. "Nucleophilic Aromatic Substitution Reactions in 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (Chp. 6.5), edited by Carlos A. M. Afonso; Nuno R. Candeias; Dulce P. Simão; Alexandre Trindade; Jaime Coelho; Robert Franzén, 545-549. United Kingdom: Royal Society of Chemistry, 2017.
    Published
  7. Mendes, Paulo J.; Silva, Tiago J. L.; Tomaz, Ana Isabel; Garcia, M. Helena; J.L. Silva, Tiago; Mendes, Paulo J. G.. "Synthesis of 1,3-Dithienylbenzo[c]thiophene". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, edited by Afonso, Carlos A M; Candeias, Nuno R; Simão, Dulce Pereira; Trindade, Alexandre F; Coelho, Jaime A S; Tan, Bin; Franzen, Robert, 888-892. Royal Society of Chemistry, 2017.
    Published
  8. Mendes, Paulo J.; Silva, Tiago JL; Tomaz, Ana Isabel; Garcia, M. Helena. "An 'Out-of-the-Box' Example for Heterocyclic Chemistry: Synthesis of 3,6-Bis-(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (Chp. 12.2.5), 745-749. United Kingdom: Royal Society of Chemistry, 2017.
    Published
  9. Pessoa, João Costa; Cavaco, I.; Correia, I.; Tomaz, I.; Adão, P.; Vale, I.; Ribeiro, V.; et al. "Vanadium Schiff Base Complexes: Chemistry, Properties, and Concerns about Possible Therapeutic Applications". In Vanadium: The Versatile Metal, edited by Kennethy Kustin; Joao Costa Pessoa; Debbie Crans, 340-351. American Chemical Society, 2007.
    Published • 10.1021/bk-2007-0974.ch024
  10. Costa Pessoa, J.; Cavaco, I.; Correia, I.; Gonçalves, G.; Tomaz, Ana Isabel; Vale, I.; Ribeiro, Vera; et al. "Vanadium complexes - concerns about possible therapeutic applications". In Metal Ions in Biology and Medicine, edited by Libbey, John, 18-23. Paris: Eurotext, 2006.
    Published
Conference abstract
  1. Tomaz, Ana Isabel; de Sousa, Andreia D.; Santos, Telma C.; Soledade Santos, M.; Luisa Corvo, M.; Matos, Cristina; Helena Garcia, M.; de Almeida, Rodrigo F. M.. "On the mechanism of action of new active ruthenium anticancer compounds: a model membrane biophysics approach". Paper presented in 18th International Conference on Biological Inorganic Chemistry, Florianopólis, 2017.
    Published
  2. Cavaco, Isabel Maria Palma Antunes; Butenko, N.; Tomaz, Isabel; Ribeiro, Vera; Pesssoa, João Costa. "Studies on the mechanism of action of an efficient vanadium inorganic nuclease, VIVO(acac)2". Paper presented in 14th International Conference on Biological Inorganic Chemistry, Nagoya, 2009.
    Published
Journal article
  1. Andres Alguacil; Franco Scalambra; Antonio Romerosa; Andreia Bento-Oliveira; Fernanda Marques; Ines Maximiano; Rodrigo F. M. de Almeida; et al. "Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives". Bioinorganic Chemistry and Applications (2023): https://doi.org/10.1155/2023/6669394.
    10.1155/2023/6669394
  2. Teixeira, R.G.; Mészáros, J.P.; Matos, B.; Côrte-Real, L.; Xavier, C.P.R.; Fontrodona, X.; Garcia, M.H.; et al. "Novel family of [RuCp(N,N)(P)]+ compounds with simultaneous anticancer and antibacterial activity: Biological evaluation and solution chemistry studies". European Journal of Medicinal Chemistry 262 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85175798383&partnerID=MN8TOARS.
    10.1016/j.ejmech.2023.115922
  3. Stefanelli, Alessia; Teixeira, Ricardo G.; Pilon, Adhan; Warmers, Rebecca; Ott, Ingo; Kowol, Christian R.; Brozovic, Anamaria; et al. "Anticancer activity and paraptosis induction of novel bipyridine-silver(I) compounds against resistant colorectal and ovarian cancer cell lines". Cancer Research (2023): https://publons.com/wos-op/publon/62927111/.
    10.1158/1538-7445.AM2023-4905
  4. Teixeira, R.G.; Salaroglio, I.C.; Oliveira, N.F.B.; Sequeira, J.G.N.; Fontrodona, X.; Romero, I.; Machuqueiro, M.; et al. "Fighting Multidrug Resistance with Ruthenium-Cyclopentadienyl Compounds: Unveiling the Mechanism of P-gp Inhibition". Journal of Medicinal Chemistry 66 20 (2023): 14080-14094. http://www.scopus.com/inward/record.url?eid=2-s2.0-85169903244&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.3c01120
  5. Dömötör, O.; Teixeira, R.G.; Spengler, G.; Avecilla, F.; Marques, F.; Lenis-Rojas, O.A.; Matos, C.P.; et al. "Ruthenium(II) polypyridyl complexes with benzothiophene and benzimidazole derivatives: Synthesis, antitumor activity, solution studies and biospeciation". Journal of Inorganic Biochemistry 238 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85141813123&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2022.112058
  6. Starosta, R.; Santos, T.C.; Dinis de Sousa, A.F.; Santos, M.S.; Corvo, M.L.; Tomaz, A.I.; de Almeida, R.F.M.. "Assessing the role of membrane lipids in the action of ruthenium(III) anticancer compounds". Frontiers in Molecular Biosciences 9 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85146468816&partnerID=MN8TOARS.
    10.3389/fmolb.2022.1059116
  7. Matos, Cristina P.; Albino, Melissa; Lopes, Joana; Viana, Ana Silveira; Côrte-Real, Leonor; Mendes, Filipa; Pessoa, João Costa; et al. "New iron(III) anti-cancer aminobisphenolate/phenanthroline complexes: Enhancing their therapeutic potential using nanoliposomes". International Journal of Pharmaceutics 623 (2022): 121925. http://dx.doi.org/10.1016/j.ijpharm.2022.121925.
    Published • 10.1016/j.ijpharm.2022.121925
  8. Ferretti, V.; Matos, C.P.; Canelas, C.; Pessoa, J.C.; Tomaz, A.I.; Starosta, R.; Correia, I.; León, I.E.. "New ternary Fe(III)-8-hydroxyquinoline–reduced Schiff base complexes as selective anticancer drug candidates". Journal of Inorganic Biochemistry 236 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85136634485&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2022.111961
  9. Lenis-Rojas, Oscar A.; Robalo, M. Paula; Tomaz, Ana Isabel; Fernandes, Alexandra R.; Roma-Rodrigues, Catarina; Teixeira, Ricardo G.; Marques, Fernanda; et al. Corresponding author: Fernández, Jesús J.. "Half-Sandwich Ru(p-cymene) Compounds with Diphosphanes: In Vitro and In Vivo Evaluation As Potential Anticancer Metallodrugs". Inorganic Chemistry 60 5 (2021): 2914-2930. http://dx.doi.org/10.1021/acs.inorgchem.0c02768.
    Published • 10.1021/acs.inorgchem.0c02768
  10. Teixeira, Ricardo G.; Belisario, Dimas C.; Fontrodona, Xavier; Romero, Isabel; Tomaz, Ana Isabel; Garcia, M. Helena; Riganti, Chiara; Valente, Andreia. Corresponding author: Valente, Andreia. "Unprecedented collateral sensitivity for cisplatin-resistant lung cancer cells presented by new ruthenium organometallic compounds". Inorganic Chemistry Frontiers 8 8 (2021): 1983-1996. http://dx.doi.org/10.1039/d0qi01344g.
    Open access • Published • 10.1039/d0qi01344g
  11. Matos, Cristina P.; Adiguzel, Zelal; Yildizhan, Yasemin; Cevatemre, Buse; Bagci-Onder, Tugba; Cevik, Ozge; Nunes, Patrique; et al. "Experimental data on novel Fe(III)-complexes containing phenanthroline derivatives for their anticancer properties". Data in Brief 27 (2019): 104548. http://dx.doi.org/10.1016/j.dib.2019.104548.
    Published • 10.1016/j.dib.2019.104548
  12. Gano, Lurdes; Pinheiro, Teresa; Matos, António P.; Tortosa, Francisco; Jorge, Tiago F.; Gonçalves, Maria S.; Martins, Marta; et al. "Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools". Anti-Cancer Agents in Medicinal Chemistry 19 10 (2019): 1262-1275. http://dx.doi.org/10.2174/1871520619666190318152726.
    10.2174/1871520619666190318152726
  13. Bruno Demoro; Andreia Bento-Oliveira; Fernanda Marques; João Costa Pessoa; Lucía Otero; Dinorah Gambino; Rodrigo F. M. de Almeida; Ana Isabel Tomaz. "Interaction with Blood Proteins of a Ruthenium(II) Nitrofuryl Semicarbazone Complex: Effect on the Antitumoral Activity". Molecules (2019): https://doi.org/10.3390/molecules24162861.
    10.3390/molecules24162861
  14. Cristina P. Matos; Yasemin Yildizhan; Zelal Adiguzel; Fernando R. Pavan; Débora L. Campos; João Costa Pessoa; Liliana P. Ferreira; et al. "New ternary iron(iii) aminobisphenolate hydroxyquinoline complexes as potential therapeutic agents". Dalton Transactions (2019): https://doi.org/10.1039/C9DT01193E.
    10.1039/C9DT01193E
  15. Matos, Cristina P.; Adiguzel, Zelal; Yildizhan, Yasemin; Cevatemre, Buse; Onder, Tugba Bagci; Cevik, Ozge; Nunes, Patrique; et al. "May iron(III) complexes containing phenanthroline derivatives as ligands be prospective anticancer agents?". European Journal of Medicinal Chemistry 176 (2019): 492-512. http://hdl.handle.net/11449/190349.
    http://dx.doi.org/10.1016/j.ejmech.2019.04.070
  16. Lenis-Rojas, Oscar A.; Robalo, Maria Paula; Tomaz, Ana Isabel; Carvalho, Andreia; Fernandes, Alexandra; Marques, Fernanda; FOLGUEIRA, MONICA; et al. "Ru-II(p-cymene) compounds as effective and selective anticancer candidates with no toxicity in vivo". Inorganic Chemistry 57 21 (2018): 13150-13166. http://hdl.handle.net/10400.21/8964.
    Published • 10.1021/acs.inorgchem.8b01270
  17. Dömötör, Orsolya; de Almeida, Rodrigo F.M.; Côrte-Real, Leonor; Matos, Cristina P.; Marques, Fernanda; Matos, António; Real, Carla; et al. Corresponding author: Tomaz, Ana Isabel. "Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes". Journal of Inorganic Biochemistry 168 (2017): 27-37. http://dx.doi.org/10.1016/j.jinorgbio.2016.12.008.
    Published • 10.1016/j.jinorgbio.2016.12.008
  18. Mendes, N.; Tortosa, F.; Valente, A.; Marques, F.; Matos, A.; Morais, T.S.; Tomaz, A.I.; Gärtner, F.; Garcia, M.H.. "In vivo performance of a ruthenium-cyclopentadienyl compound in an orthotopic triple negative breast cancer model". Anti-Cancer Agents in Medicinal Chemistry 17 1 (2017): 126-136. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015652299&partnerID=MN8TOARS.
    10.2174/1871520616666160922165133
  19. Garcia, Maria Helena; Valente, Andreia; Morais, Tania S.; Tomaz, Ana Isabel. "Ruthenium new drug: paving the way for cancer therapy". Journal of Biological Inorganic Chemistry (2017): https://publons.com/wos-op/publon/15344537/.
  20. Morais, T.S.; Valente, A.; Tomaz, A.I.; Marques, F.; Garcia, M.H.. "Tracking antitumor metallodrugs: Promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds". Future Medicinal Chemistry 8 5 (2016): 527-544. http://www.scopus.com/inward/record.url?eid=2-s2.0-84966471252&partnerID=MN8TOARS.
    10.4155/fmc.16.7
  21. Côrte-Real, Leonor; Robalo, M. Paula; Marques, Fernanda; Nogueira, Guilherme; Avecilla, Fernando; J.L. Silva, Tiago; C. Santos, Filipa; et al. "The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds". Journal of Inorganic Biochemistry 150 (2015): 148-159. http://dx.doi.org/10.1016/j.jinorgbio.2015.06.015.
    10.1016/j.jinorgbio.2015.06.015
  22. Rodríguez Arce, E.; Sarniguet, C.; Moraes, T.S.; Vieites, M.; Tomaz, A.I.; Medeiros, A.; Comini, M.A.; et al. "A new ruthenium cyclopentadienyl azole compound with activity on tumor cell lines and trypanosomatid parasites". Journal of Coordination Chemistry 68 16 (2015): 2923-2937. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982070308&partnerID=MN8TOARS.
    10.1080/00958972.2015.1062480
  23. Cipriani, M.; Toloza, J.; Bradford, L.; Putzu, E.; Vieites, M.; Curbelo, E.; Tomaz, A.I.; et al. "Effect of the Metal Ion on the anti T. cruzi Activity and Mechanism of Action of 5-Nitrofuryl-Containing Thiosemicarbazone Metal Complexes". European Journal of Inorganic Chemistry (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84921525583&partnerID=MN8TOARS.
    10.1002/ejic.201402614
  24. Fernández, M.; Arce, E.R.; Sarniguet, C.; Morais, T.S.; Tomaz, A.I.; Azar, C.O.; Figueroa, R.; et al. "Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasites". Journal of Inorganic Biochemistry 153 (2015): 306-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982686493&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2015.06.018
  25. Butenko, N.; Pinheiro, J.P.; Da Silva, J.P.; Tomaz, A.I.; Correia, I.; Ribeiro, V.; Costa Pessoa, J.; Cavaco, I.. "The effect of phosphate on the nuclease activity of vanadium compounds". Journal of Inorganic Biochemistry 147 (2015): 165-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930869864&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2015.04.010
  26. Tomaz, Ana; Luís, Daniel V.; Silva, Joana; Tomaz, Ana Isabel; de Almeida, Rodrigo F. M.; Larguinho, Miguel; Baptista, Pedro V.; et al. "Insights into the mechanisms underlying the anti-proliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies". Journal of Biological Inorganic Chemistry 19 6 (2014): 787-803. http://dx.doi.org/10.1007/s00775-014-1110-0.
    Published • 10.1007/s00775-014-1110-0
  27. Côrte-Real, L.; Mendes, F.; Coimbra, J.; Morais, T.S.; Tomaz, A.I.; Valente, A.; Garcia, M.H.; et al. "Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes". Journal of Biological Inorganic Chemistry 19 6 (2014): 853-867. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905864221&partnerID=MN8TOARS.
    10.1007/s00775-014-1120-y
  28. Demoro, Bruno; de Almeida, Rodrigo F. M.; Marques, Fernanda; Matos, Cristina P.; Otero, Lucía; Costa Pessoa, João; Santos, Isabel; et al. Corresponding author: Tomaz, Ana Isabel. "Screening organometallic binuclear thiosemicarbazone ruthenium complexes as potential anti-tumour agents: cytotoxic activity and human serum albumin binding mechanism". Dalton Transactions 42 19 (2013): 7131-7146. http://dx.doi.org/10.1039/c3dt00028a.
    Published • 10.1039/c3dt00028a
  29. Mehtab, S.; Gonçalves, G.; Roy, S.; Tomaz, A.I.; Santos-Silva, T.; Santos, M.F.A.; Romão, M.J.; et al. "Interaction of vanadium(IV) with human serum apo-transferrin". Journal of Inorganic Biochemistry 121 (2013): 187-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873700367&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2012.12.020
  30. Matos, C.P.; Valente, A.; Marques, F.; Adão, P.; Paula Robalo, M.; De Almeida, R.F.M.; Pessoa, J.C.; et al. Corresponding author: Tomaz, A.I.. "New polydentate Ru(III)-Salan complexes: Synthesis, characterization, anti-tumour activity and interaction with human serum proteins". Inorganica Chimica Acta 394 (2013): 616-626. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868218698&partnerID=MN8TOARS.
    10.1016/j.ica.2012.09.026
  31. Côrte-Real, L.; Matos, A.P.; Alho, I.; Morais, T.S.; Tomaz, A.I.; Garcia, M.H.; Santos, I.; Bicho, M.P.; Marques, F.. "Cellular uptake mechanisms of an antitumor ruthenium compound: The endosomal/lysosomal system as a target for anticancer metal-based drugs". Microscopy and Microanalysis 19 5 (2013): 1122-1130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884579362&partnerID=MN8TOARS.
    10.1017/S143192761300175X
  32. Gonçalves, A.C.; Morais, T.S.; Robalo, M.P.; Marques, F.; Avecilla, F.; Matos, C.P.; Santos, I.; Tomaz, A.I.; Garcia, M.H.. "Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands". Journal of Inorganic Biochemistry 129 (2013): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882795489&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2013.07.033
  33. Gonçalves, G.; Tomaz, I.; Correia, I.; Veiros, L.F.; Castro, M.M.C.A.; Avecilla, F.; Palacio, L.; et al. "A novel V(IV)O-pyrimidinone complex: Synthesis, solution speciation and human serum protein binding". Dalton Transactions 42 33 (2013): 11841-11861. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881157675&partnerID=MN8TOARS.
    Published • 10.1039/c3dt50553g
  34. Santos, T. C.; Matos, C. P.; Santos, F. C.; Corvo, L. M.; Garcia, M.; Tomaz, A. I.; de Almeida, R. F.. "Interaction of new active Ruthenium anticancer agents with lipid bilayers". European Biophysics Journal (2013): https://publons.com/wos-op/publon/2977001/.
  35. Cobbina, Enoch; Mehtab, Sameena; Correia, Isabel; Goncalves, Gisela; Tomaz, Isabel; Cavaco, Isabel; Jakusch, Tamas; et al. "Binding of Oxovanadium(IV) Complexes to Blood Serum Albumins". Journal of the Mexican Chemical Society 57 3 (2013): 180-191. https://publons.com/wos-op/publon/5182080/.
    10.29356/JMCS.V57I3.205
  36. Tomaz, Ana Isabel; Jakusch, Tamás; Morais, Tânia S.; Marques, Fernanda; de Almeida, Rodrigo F.M.; Mendes, Filipa; Enyedy, Éva A.; et al. Corresponding author: Tomaz, Ana Isabel. "[RuII(eta5-C5H5)(bipy)(PPh3)]+, a promising large spectrum antitumor agent: Cytotoxic activity and interaction with human serum albumin". Journal of Inorganic Biochemistry 117 (2012): 261-269. http://dx.doi.org/10.1016/j.jinorgbio.2012.06.016.
    Published • 10.1016/j.jinorgbio.2012.06.016
  37. Sanna, D.; Buglyó, P.; Tomaz, A.I.; Pessoa, J.C.; Borovic, S.; Micera, G.; Garribba, E.. "VIVO and CuII complexation by ligands based on pyridine nitrogen donors". Dalton Transactions 41 41 (2012): 12824-12838. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867325671&partnerID=MN8TOARS.
    10.1039/c2dt31109g
  38. Correia, I.; Jakusch, T.; Cobbinna, E.; Mehtab, S.; Tomaz, I.; Nagy, N.V.; Rockenbauer, A.; Costa Pessoa, J.; Kiss, T.. "Evaluation of the binding of oxovanadium(iv) to human serum albumin". Dalton Transactions 41 21 (2012): 6477-6487. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862839040&partnerID=MN8TOARS.
    10.1039/c2dt12193j
  39. Gambino, Dinorah; Demoro, Bruno; Sarniguet, Cynthia; Otero, Lucia; Maya, Juan D.; Olea-Azar, Claudio; Medeiros, Andrea; et al. "Ruthenium complexes as promising hits for the design of potential agents against multiple trypanosomatid parasites". Abstracts of Papers of the American Chemical Society (2012): https://publons.com/wos-op/publon/13257968/.
  40. Correia, Isabel; Marcão, Susana; Koci, Kamila; Tomaz, Isabel; Adão, Pedro; Kiss, Tamás; Jakusch, Tamás; et al. "Vanadium(IV) and -(V) Complexes of Reduced Schiff Bases Derived from Aromatic o-Hydroxyaldehydes and Tyrosine Derivatives". European Journal of Inorganic Chemistry 2011 5 (2011): 694-708. http://dx.doi.org/10.1002/ejic.201000948.
    10.1002/ejic.201000948
  41. Gambino, D.; Fernández, M.; Santos, D.; Etcheverría, G.A.; Piro, O.E.; Pavan, F.R.; Leite, C.Q.F.; Tomaz, I.; Marques, F.. "Searching for gallium bioactive compounds: Gallium(III) complexes of tridentate salicylaldehyde semicarbazone derivatives". Polyhedron 30 7 (2011): 1360-1366. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953861653&partnerID=MN8TOARS.
    10.1016/j.poly.2011.02.037
  42. Pessoa, J.C.; Tomaz, I.. "Transport of therapeutic vanadium and ruthenium complexes by blood plasma components". Current Medicinal Chemistry 17 31 (2010): 3701-3738. http://www.scopus.com/inward/record.url?eid=2-s2.0-78449246414&partnerID=MN8TOARS.
    10.2174/092986710793213742
  43. Butenko, Nataliya; Tomaz, Ana Isabel; Nouri, Ofelia; Escribano, Esther; Moreno, Virtudes; Gama, Sofia; Ribeiro, Vera; et al. "DNA cleavage activity of VIVO(acac)2 and derivatives". Journal of Inorganic Biochemistry 103 4 (2009): 622-632. http://dx.doi.org/10.1016/j.jinorgbio.2009.01.003.
    10.1016/j.jinorgbio.2009.01.003
  44. Pessoa, J.C.; Correia, I.; Gonçalves, G.; Tomaz, I.. "Circular dichroism in coordination compounds". Journal of the Argentine Chemical Society 97 1 (2009): 151-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959600855&partnerID=MN8TOARS.
  45. Bošnjakovic-Pavlovic, N.; Biré, A.S.-D.; Tomaz, I.; Bouhmaida, N.; Avecilla, F.; Mioc, U.B.; Pessoa, J.C.; Ghermani, N.E.. "Electronic properties of a cytosine decavanadate: Toward a better understanding of chemical and biological properties of decavanadates". Inorganic Chemistry 48 20 (2009): 9742-9753. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350610696&partnerID=MN8TOARS.
    10.1021/ic9008575
  46. Benítez, J.; Guggeri, L.; Tomaz, I.; Pessoa, J.C.; Moreno, V.; Lorenzo, J.; Avilés, F.X.; Garat, B.; Gambino, D.. "A novel vanadyl complex with a polypyridyl DNA intercalator as ligand: A potential anti-protozoa and anti-tumor agent". Journal of Inorganic Biochemistry 103 10 (2009): 1386-1394. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349410228&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2009.07.013
  47. Benítez, J.; Guggeri, L.; Tomaz, I.; Arrambide, G.; Navarro, M.; Costa Pessoa, J.; Garat, B.; Gambino, D.. "Design of vanadium mixed-ligand complexes as potential anti-protozoa agents". Journal of Inorganic Biochemistry 103 4 (2009): 609-616. http://www.scopus.com/inward/record.url?eid=2-s2.0-62649124172&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2008.10.018
  48. Faneca, H.; Figueiredo, V.A.; Tomaz, I.; Gonçalves, G.; Avecilla, F.; Pedroso de Lima, M.C.; Geraldes, C.F.G.C.; Pessoa, J.C.; Castro, M.M.C.A.. "Vanadium compounds as therapeutic agents: Some chemical and biochemical studies". Journal of Inorganic Biochemistry 103 4 (2009): 601-608. http://www.scopus.com/inward/record.url?eid=2-s2.0-62349102649&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2008.11.004
  49. Jakusch, T.; Hollender, D.; Enyedy, E.A.; González, C.S.; Montes-Bayón, M.; Sanz-Medel, A.; Costa Pessoa, J.; Tomaz, I.; Kiss, T.. "Biospeciation of various antidiabetic VIVO compounds in serum". Dalton Transactions 13 (2009): 2428-2437. http://www.scopus.com/inward/record.url?eid=2-s2.0-62749086750&partnerID=MN8TOARS.
    10.1039/b817748a
  50. Pessoa, J.C.; Marcão, S.; Correia, I.; Gonçalves, G.; Dörnyei, A.; Kiss, T.; Jakusch, T.; et al. "Vanadium (IV and V) complexes of reduced Schiff bases derived from the reaction of aromatic o-hydroxyaldehydes and diamines containing carboxyl groups". European Journal of Inorganic Chemistry 18 (2006): 3595-3606. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749079002&partnerID=MN8TOARS.
    10.1002/ejic.200600309
  51. Delgado, T.C.; Tomaz, A.I.; Correia, I.; Costa Pessoa, J.; Jones, J.G.; Geraldes, C.F.G.C.; Castro, M.M.C.A.; et al. "Uptake and metabolic effects of insulin mimetic oxovanadium compounds in human erythrocytes". Journal of Inorganic Biochemistry 99 12 (2005): 2328-2339. http://www.scopus.com/inward/record.url?eid=2-s2.0-28544439916&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2005.08.014
  52. Abrunhosa, F.; Faria, S.; Gomes, P.; Tomaz, I.; Pessoa, J.C.; Andreu, D.; Bastos, M.. "Interaction and lipid-induced conformation of two cecropin-melittin hybrid peptides depend on peptide and membrane composition". Journal of Physical Chemistry B 109 36 (2005): 17311-17319. http://www.scopus.com/inward/record.url?eid=2-s2.0-25444466265&partnerID=MN8TOARS.
    10.1021/jp051572e
  53. Bosnjakovic-Pavlovic, N.; Bouhmaida, N.; Spasojevic-de Bire, A.; Correia, I.; Tomaz, I.; Avecilla, F.; Pessoa, J.; Mioc, U. B.; Ghermani, N. E.. "Investigation of the Cytosine-Decavanadate Interaction from an Experimental Charge Density: a Supramolecular Arrangement of Na3V10O28(C4N3OH5)(3)(C4N3OH6)(3)". Acta Crystallographica Section A: Foundations and Advances (2004): https://publons.com/wos-op/publon/27416560/.
    10.1107/S0108767304099349
  54. Costa Pessoa, J.; Tomaz, I.; Henriques, R.T.. "Preparation and characterisation of vanadium complexes derived from salicylaldehyde or pyridoxal and sugar derivatives". Inorganica Chimica Acta 356 (2003): 121-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-1042276502&partnerID=MN8TOARS.
    10.1016/S0020-1693(03)00395-5
  55. Kiss, T.; Jakusch, T.; Costa Pessoa, J.; Tomaz, I.. "Interactions of VO(IV) with oligopeptides". Coordination Chemistry Reviews 237 1-2 (2003): 123-133. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037296508&partnerID=MN8TOARS.
    10.1016/S0010-8545(02)00222-9
  56. Costa Pessoa, J.; Calhorda, M.J.; Cavaco, I.; Correia, I.; Duarte, M.T.; Felix, V.; Henriques, R.T.; Piedadea, M.F.M.; Tomaza, I.. "Molecular modelling studies of N-salicylideneamino acidato complexes of oxovanadium(IV). Molecular and crystal structure of a new dinuclear LOVIV-O-VvOL mixed valence complex". Journal of the Chemical Society, Dalton Transactions 23 (2002): 4407-4415. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037039112&partnerID=MN8TOARS.
    Published • 10.1039/b205843j
  57. Jakusch, T.; Buglyó, P.; Tomaz, A.I.; Costa Pessoa, J.; Kiss, T.. "Thiolate-S as anchoring donor in the binary and ternary VO(IV) complexes of mercaptopropionylglycine". Inorganica Chimica Acta 339 (2002): 119-128. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037111895&partnerID=MN8TOARS.
    10.1016/S0020-1693(02)00919-2
  58. Costa Pessoa, J.; Tomaz, I.; Kiss, T.; Kiss, E.; Buglyó, P.. "The systems VIVO2+-glutathione and related ligands: A potentiometric and spectroscopic study". Journal of Biological Inorganic Chemistry 7 3 (2002): 225-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036941507&partnerID=MN8TOARS.
    10.1007/s007750100289
  59. Costa Pessoa, J; Tomaz, I; Kiss, T; Buglyó, P. "The system VO2++oxidized glutathione: a potentiometric and spectroscopic study". Journal of Inorganic Biochemistry 84 3-4 (2001): 259-270. http://dx.doi.org/10.1016/s0162-0134(00)00233-6.
    Published • 10.1016/s0162-0134(00)00233-6
  60. Costa Pessoa, J.; Tomaz, I.; Kiss, T.; Buglyó, P.. "The system VO2++oxidized glutathione: A potentiometric and spectroscopic study". Journal of Inorganic Biochemistry 84 3-4 (2001): 259-270. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038261868&partnerID=MN8TOARS.
  61. Correia, I; Pessoa, JC; Kiss, T; Jakusch, T; Marcao, S; Tomaz, I; Rodrigues, L. "Deprotonation and coordination to oxovanadium(IV) and copper(II) of two dipeptide amide nitrogen atoms. A potentiometric and spectroscopic study". Journal of Inorganic Biochemistry (2001): https://publons.com/wos-op/publon/13524158/.
  62. Pessoa, JC; Calhorda, MJ; Felix, V; Gama, S; Correia, I; Duarte, MT; Marcao, S; Piedade, MFM; Tomaz, I. "N-salicylideneamino acidate complexes of oxovanadium(IV). Stability of the CS and AS diastereomers in solution". Journal of Inorganic Biochemistry (2001): https://publons.com/wos-op/publon/9288101/.
  63. Tomaz, I; Pessoa, JC; Correia, I; Marcao, S. "Preparation of oxovanadium(IV) Schiff base complexes derived from aromatic o-hidroxyaldehydes and simple sugars containing amino groups". Journal of Inorganic Biochemistry (2001): https://publons.com/wos-op/publon/13524164/.
  64. Pessoa, JC; Tomaz, I; Kiss, T; Buglyo, P. "The system VO2+ +oxidized glutathione: a potentiometric and spectroscopic study". Journal of Inorganic Biochemistry (2001): https://publons.com/wos-op/publon/5986477/.
    10.1016/S0162-0134(00)00233-6
  65. Costa Pessoa, J.; Cavaco, I.; Correia, I.; Tomaz, I.; Duarte, T.; Matias, P.M.. Corresponding author: Costa Pessoa, J.. "Oxovanadium(IV) complexes with aromatic aldehydes". Journal of Inorganic Biochemistry 80 1-2 (2000): 35-39. https://www.sciencedirect.com/science/article/pii/S0162013400000374?via%3Dihub.
    Published • 10.1016/S0162-0134(00)00037-4
  66. Pessoa, J.C.; Cavaco, I.; Correia, I.; Duarte, M.T.; Gillard, R.D.; Henriques, R.T.; Higes, F.J.; Madeira, C.; Tomaz, I.. Corresponding author: Pessoa, J.C.. "Preparation and characterisation of new oxovanadium(IV) Schiff base complexes derived from amino acids and aromatic o-hydroxyaldehydes". Inorganica Chimica Acta 293 1 (1999): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-0002902614&partnerID=MN8TOARS.
    10.1016/S0020-1693(99)00196-6
  67. Tomaz, I; Pessoa, JC; Kiss, T; Buglyo, P; Kiss, E. "The system glutathione +VO2+ and related ligands: a potentiometric and spectroscopic study". Journal of Inorganic Biochemistry (1999): https://publons.com/wos-op/publon/5986484/.
  68. Bernalte, A.; Barros, F.J.G.; Cavaco, I.; Pessoa, J.C.; Gillard, R.D.; Higes, F.J.; Tomaz, I.. Corresponding author: Pessoa, J.C.. "X-ray characterization of an unusual product obtained from [VO(Sal-Phe)(H2O)] in H2O\pyridine solutions". Polyhedron 17 19 (1998): 3269-3274. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001064884&partnerID=MN8TOARS.
    Published • 10.1016/S0277-5387(98)00105-3
  69. Costa Pessoa, J.; Gajda, T.; Gillard, R.D.; Kiss, T.; Luz, S.M.; Moura, J.J.G.; Tomaz, I.; Telo, J.P.; Török, I.. "Oxovanadium(IV) complexes of the dipeptides glycyl-L-aspartic acid, L-aspartylglycine and related ligands; a spectroscopic and potentiometric study". Journal of the Chemical Society - Dalton Transactions 21 (1998): 3587-3600. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748451474&partnerID=MN8TOARS.
    10.1039/a801888j
  70. Costa Pessoa, J.; Duarte, M.T.; Gillard, R.D.; Madeira, C.; Matias, P.M.; Tomaz, I.; Pessoa, João Costa; et al. "Preparation of [VO(sal-L-Trp)(H2O)] (sal-L-Trp = N-salicylidene-L-tryptophanate) and characterisation of an unusual product obtained from its solutions in water-pyridine". Journal of the Chemical Society - Dalton Transactions 23 (1998): 4015-4020. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748660729&partnerID=MN8TOARS.
    Published • 10.1039/a805768k
Online resource
  1. Tomaz, Ana Isabel;. Global Medical Discovery (online continuous dissemination): : Paper selected : : [RuII( eta5-C5H5)(bipy)(PPh3)]+, a promising large spectrum antitumor agent: cytotoxic activity and interaction with Human Serum Albumin. 2012. http://globalmedicaldiscovery.com/key-scientific-articles/ruii%CE%B7%E2%81%B5-c%E2%82%85h%E2%82%85bipypph%E2%82%83%E2%81%BA-a-promising-large-spectrum-antitumor-agent-cytotoxic-activity-and-interaction-with-human-serum-albumin/.

Intellectual property

Patent
  1. Garcia, Maria Helena Anselmo Viegas, 1947-; Valente, Andreia Marques, 1983-; Morais, Tânia S.; Ana Isabel Antunes Tomaz Diniz. 2021. "Macromolecular transition metal complexes for treatment of cancer and process for their preparation". United States.
  2. Garcia, Maria Helena Anselmo Viegas, 1947-; Valente, Andreia Marques, 1983-; Morais, Tânia S.; Ana Isabel Antunes Tomaz Diniz. 2020. "MACROMOLECULAR TRANSITION METAL COMPLEXES FOR TREATMENT OF CANCER AND PROCESS FOR THEIR PREPARATION | [MAKROMOLEKULARE ÜBERGANGSMETALLKOMPLEXE ZUR BEHANDLUNG VON KREBS UND VERFAHREN ZU DEREN HERSTELLUNG]".
    Granted/Issued
  3. Garcia, M. Helena; Valente, Andreia; Morais, Tânia S.; Tomaz, Ana Isabel; Garcia, Maria Helena Anselmo Viegas, 1947-; Valente, Andreia Marques, 1983-; Morais, Tânia S.; Ana Isabel Antunes Tomaz Diniz. 2015. ""Macromolecular transition metal complexes for treatment of cancer and process for their preparation"". United States.
    Granted/Issued
  4. Garcia, M. Helena; Morais, T.S.; Tomaz, Ana Isabel; Marques, Fernanda. 2013. ""Water-soluble organometallic ruthenium and iron compounds presenting heteroaromatic ligands"".
  5. Garcia, M. Helena; Morais, T.S.; Tomaz, Ana Isabel; Marques, Fernanda; Mendes, F.. 2013. ""Transition metal complexes for pharmaceutical applications"". Portugal.
    Pending
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/07/05 - Ruthenium complexes as anticancer metallodrugs 12th Inorganic & Bioinorganic Chemistry Conference-12IBCC
(Oporto, Portugal)
2018 - Ruthenium complexes as anticancer metallodrugs -- OC12 -- 12th Inorganic & Bioinorganic Chemistry Conference - 12 IBCC, 5-6th July 2018, Oporto, Portugal. 12th Inorganic & Bioinorganic Chemistry Conference-12IBCC
(Portugal)
2017/12/04 Scientific Meeting (International) | Invited | "Ruthenium complexes and their potential in cancer therapy" -- http://www.ic3tc2017.com/index.php/scientific-program/oral-contributions/ : : O09A IC3TC Conference, 4th-7th December 2017, Caparica, Portugal IC3TC - 2nd International Caparica Christmas Congress on Translational Chemistry
BioScope : : Proteomass (http://www.bioscopegroup.org/) (Caparica, Portugal)
2017/08 'On the mechanism of action of new active ruthenium anticancer compounds: a model membrane biophysics approach' -- ICBIC18 -- International Conference on Biological Inorganic Chemistry, July 31st - August 4th 2017, Florianópolis, Brazil. ICBIC18 - International Conference on Biological Inorganic Chemistry
(Florianopolis, Brazil)
2017/05/20 Scientific Meeting (International) | "Ruthenium compounds as metallodrug candidates for cancer therapy" -- (Invited) http://www.bitcongress.com/Cancer2017/programlayout.asp : : IL07 BIT’s 10th Annual World Congress of Cancer-2017 (Session 501: Anti-cancer Drug Delivery and Cancer Drug Design)
BIT (http://www.bitcongress.com/Cancer2017/programlayout.asp) (Barcelona, Spain)
2016/10/07 Scientific Meeting | Tracking antitumor metallodrugs with ruthenium candidates -- (Invited : : Keynote ) | KL1 at 11th ICC-SPQ (1st meeting of the Inorganic and Bioinorganic Chemistry Division of the Portuguese Society of Chemistry) 7-8 October, 2016, Sintra, Portugal | http://11icc.eventos.chemistry.pt/images/11thICC_1stMIBCDSPQ_Book_of_Abstracts.pdf 11th Inorganic Chemistry Conference - 11th ICC - SPQ
Sociedade Portuguesa de Química (Chemical Portuguese Society) (Sintra, Portugal)
2015/12/09 Scientific Meeting (International) | "Developing new ruthenium compounds as anti-tumor metallodrugs" -- (Invited) http://www.bioscopegroup.org/ic3tc2015/index.html IC3TC - 1st International Caparica Christmas Congress on Translational Chemistry IC3TC
BioScope : : Proteomass (http://www.bioscopegroup.org/) (Caparica, Portugal)
2013/10/13 Scientific Meeting (International) |"On the field of metallodrugs – new ruthenium compounds as anti-tumor agents" -- (Invited) MedChem&CADD 2013 (October 15-17, 2013) MedChem&CADD 2013 - 2nd International Conference on Medicinal Chemistry & Computer Aided Drug Designing
(Las Vegas, United States)
2012 -Promising organometallic Ruthenium metallodrugs: [Ru(II)(eta-5-Cp)(bpy)(PPh3)]+, a large spectrum antitumor agent - Ana Isabel Tomaz (presenting author) with (co-authors) Tamás Jakusch, Tânia S. Morais, Rodrigo. F. M. de Almeida, Fernanda Marques, Filipa Mendes, Éva A. Enyedy, M. Helena Garcia, 3º Encontro Nacional de Química Terapêutica da Sociedade Portuguesa de Química (3ENQT) - OC18 - 28th-30th November 2012, Aveiro, Portugal. 3º Encontro Nacional de Química Terapêutica da Sociedade Portuguesa de Química (3ENQT)
(Aveiro, Portugal)
2012 - New polydentate Ru(III)-Salan complexes: synthesis, characterization, anti-tumour activity and interaction with human serum proteins - International Symposium on Metal Complexes (ISMEC 2012) - OC47 - 18th -22nd.June 2012, Lisbon, Portugal. International Symposium on Metal Complexes (ISMEC 2012)
(Lisbon, Portugal)
2011 “A promising large spectrum anti-tumor ruthenium agent: interaction with serum proteins and mechanisms of cell death” A. I. Tomaz (presenting author) with (cco-authors) T. Jakusch, T. S. Morais, R. F. M. de Almeida, F. Marques, F. Mendes, E. A. Enyedy, J. Costa Pessoa, T. Kiss, M. H. Garcia, 4th European Conference on Chemistry for Life Sciences (4ECCLS) 31th.Ago – 3rd.Set. 2011, Budapest, Hungary.
(Budapest)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2014 - 2019/07/04 Anti-tumoral aminophenolate ruthenium and iron complexes
Co-supervisor of Pereira de Matos, Cristina
Química (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 Study of the mechanism of action of new ruthenium compounds with antitumor activity || Estudo do mecanismo de ação de novos compostos de ruténio com atividade antitumoral
Co-supervisor of Andreia Catarina Guerreiro Morais de Carvalho
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2016 Development of metallodrugs: new ruthenium complexes containing macromolecular ligands as antitumour agents || Desenvolvimento de metalofármacos: novos complexos de ruténio contendo ligandos macromoleculares como agentes antitumorais
Co-supervisor of Pereira, Maria Inês Genro
 Química (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2015 Synthesis of new metal ion complexes and evaluation of their potential as metallodrugs || Síntese de novos complexos de iões metálicos e avaliação do seu potencial como metalofármacos
Supervisor of Ana Sofia Rodrigues Freitas da Costa Assis
 Química (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2015 Development of new metal complexes with potential interest in cancer therapy || Desenvolvimento de novos complexos metálicos com potencial interesse na terapia do cancro
Supervisor of Poeta, Ana Cristina Eufrásio
 Química (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2015 The role of the cell membrane in cancer therapy with new ruthenium compounds || O papel da membrana celular na terapia do cancro com novos compostos de ruténio
Co-supervisor of Sousa, Andreia Filipa Dinis de
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2014/07 Transport in the blood of an anti-tumor water-soluble ruthenium cyclopentadienyl complex: a Fluorescence study on albumin binding
Supervisor of Martinéz, Ana Maria Medina
EMQUAL - Erasmus Mundus Master in Quality in Analytical Laboratories (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2012 - 2013 Interaction of new anti-tumour ruthenium compounds with lipid bilayers: alternative mechanisms of action in metallopharmaceuticals || Interação de novos compostos de ruténio anti-tumorais com bicamadas lipídicas: mecanismos de ação alternativos em metalofármacos
Co-supervisor
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011 - 2012 Synthesis of new Fe(II) organometallic compounds: studies of their potential as anticancer agents || Síntese de novos compostos organometálicos de Fe(II): estudos das suas potencialidades como agentes anticancerígenos
Co-supervisor of Gonçalves, Ana Cristina Teixeira Martins
 Química Inorgânica Biomédica || Aplicações em Diagnóstico e Terapia (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 - 2011 Metal ion complexes of interest in cancer therapy: interaction studies with biomolecules || Complexos de iões metálicos com interesse na terapia do cancro: estudos de interacção com biomoléculas
Supervisor
 Química Inorgânica Biomédica – Aplicações em Diagnóstico e Terapia (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/08/25 - 2021/08/27 2021 | International Congress | Chair, Organizing Committee 2nd European NECTAR Conference - COST Action 18202 (2021 - 2021)
Conference (Other)
 Universidade de Lisboa Centro de Química Estrutural, Portugal
2014/10/01 - 2017/12/31 CQE@Ciências SEMINARS - series of monthly scientific seminars, open and accessible, covering several topics of Chemistry, held at the R&D Centro de Ciências Moleculares e Materiais (Faculty of Sciences, Lisbon University). These seminars were presented by Researchers, Professors, final-year PhD. students and invited guests with recognized expertise in their field, and were intended for all: students (BSc, MSc, PhD), professors and researchers. (2015 - 2017)
Meeting (Member of the Organising Committee)
 Centro de Química Estrutural - Faculty of Sciences, Portugal
2012 - 2013 CCMM SEMINARS - series of monthly scientific seminars, open and accessible, covering several topics of Chemistry, held at the R&D Centro de Ciências Moleculares e Materiais (Faculty of Sciences, Lisbon University). These seminars were presented by Researchers, Professors, final-year PhD. students and invited guests with recognized expertise in their field, and were intended for all: students (BSc, MSc, PhD), professors and researchers. This activity was maintained until the R&D Unit CCMM was extinct due to its integration into the R&D unit CQE. (2012/01/01 - 2013/12/31)
Meeting (Member of the Organising Committee)
 Centro de Ciências Moleculares e Materiais - Faculdade de Ciências Universidade de Lisboa, Portugal
2008/01/01 - 2008/07/19 V6 - 6th International Vanadium Symposium | Member of Organizing Committee http://www.vanadiumsix.com/ ; https://www.degruyter.com/view/j/ci.2009.31.issue-2/ci.2009.31.2.27b/ci.2009.31.2.27b.xml The IUPAC-sponsored conference was supported by the Portuguese Chemical Society. Conference chairman: João Costa Pessoa (CQE-IST, UTLisbon) Conference chairman: Hitoshi Michibata (Hiroshima University, Japan), Kan Kanamori (University of Toyama, Japan) (2008/07/17 - 2008/07/19)
Congress (Member of the Organising Committee)
 Centro de Química Estrutural - Instituto Superior Técnico, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/09 - Current Noite Europeia dos Investigadores, NEI2021 Ana Isabel Tomaz, Andreia Valente, Tânia Morais - - Podem os metalofármacos ser uma boa aposta para a terapia do cancro? - Festival de Curtas - Química para Todos@ULisboa.
Other
 Noite Europeia dos Investigadores, NEI2021
Universidade de Lisboa Centro de Química Estrutural, Portugal
2019/01/29 - 2019/01/29 | Outreach Activity | IYPT - International Year of the Periodic Table | Flashmob Flashmob involving both students and professors/researchers, each identified as an Element of the Periodic Tableand performed on the Periodic Table paint located on the entrance of C8 building -FCUL. The event was filmed by air and on the ground. https://photos.app.goo.gl/t9o8aTYdreixDTjh7; http://iypt2019.campus.ciencias.ulisboa.pt/index.html ; https://youtu.be/bmVMJoynb1Q
Exhibition
 FlashMob | Cerimónia de abertura do Ano Internacional da Tabela Periódica 2019
Universidade de Lisboa Faculdade de Ciências, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/10/31 'Avaliação do potencial antiproliferativo de complexos de cobre (II) em células tumorais '
(Thesis) Main arguer
 Ana Rita Santos Casimiro (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/10/31 'Avaliação de complexos metálicos de Cobre (Cu(II)) e de Platina (Pt(II)) como agentes antiproliferativos em células tumorais '
(Thesis) Main arguer
 Cristiana de Jesus Rodrigues Marques (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/05/30 'Synthesis, characterization and antiproliferative activity of iridium organometallic complexes bearing N,N-chelating ligands'
(Thesis) Main arguer
 Marta Sofia Horta Meireles (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/12/10 Complexos antitumorais de cobre e vanádio contendo derivados da vitamina B6 e fenantrolinas
(Thesis) Arguer
 Patrique Nelson Ramos Nunes (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/06/08 'Effects of CORM-3 formulations in in vitro and in vivo models of inflammation' (http://hdl.handle.net/10362/99735)
(Thesis) Main arguer
 Inês Mendonça Lourenço Martins (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/12/18 "Evaluation of Schiff Bases and its metal complexes with potential therapeutic applications" [Erasmus Mundus - Master Course in Chemical Innovation and Regulation - EMMC-ChIR] (http://hdl.handle.net/10400.1/13984)
(Thesis) Main arguer
 Israel Alemayehu Tekamo (http://hdl.handle.net/10400.1/13984) (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2018/11/30 "Caracterização do potencial antiproliferativo de um novo composto de prata" (http://hdl.handle.net/10362/56681)
(Thesis) Main arguer
 Joana Paixão Almeida (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/12/22 Compuestos moleculares y supramoleculares de metales de transición con potenciales aplicaciones (https://ruc.udc.es/dspace/handle/2183/20148)
(Thesis) Arguer
 Cives, Ismael Marcos (PhD)
Universidade da Coruña Facultade de Ciencias, Spain
2017/09/20 "Synthesis, characterization and biological evaluation of zinc(II) complexes with phenanthroline derivatives and s-methyl dithiocarbazate schiff bases" [Erasmus Mundus MSc in Chemical Innovation and Regulation - EMMC-ChIR] .(http://hdl.handle.net/10400.1/10160)
(Thesis) Main arguer
 Yemataw Addis Alemu (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2017/07/17 The role of ABC proteins in the mechanism of action of promising ruthenium anticancer agents (http://hdl.handle.net/10451/31667)
(Thesis) Main arguer
 Patrícia Alexandra Madeira Gírio (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015/12/11 Biological characterization and vectorization of new compounds with antiproliferative effects (http://hdl.handle.net/10451/22642)
(Thesis) Main arguer
 Joana Sanches Coimbra (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013/11/14 Nitric Oxide interaction with simple iron-sulfur proteins (http://hdl.handle.net/10451/9932)
(Thesis) Main arguer
 Rodrigo Gonçalves David (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/03/28 Copper complexes as therapeutic drugs: use of analytical spectroscopic methods for evaluation of their transport in blood [Erasmus Mundus MSc. EMQUAL - Master in Quality in Analytical Laboratories] (http://hdl.handle.net/10400.1/10635)
(Thesis) Main arguer
 Sladana Borovic (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2011/03/30 Spectroscopic study of V(IV)O2+ binding on serum albumins [Erasmus Mundus MSc. EMQUAL - Master in Quality in Analytical Laboratories]
(Thesis) Main arguer
 Ennoch Cobina (Master)
Universidade do Algarve - Campus de Gambelas, Portugal

Association member

Society Organization name Role
2020/03/01 - Current Cost Action NECTAR - Network for Equilibria and Chemical Thermodynamics Advanced Research (CA 18202) Action Participant in Workgroups (WG) WG2, WG4 and WG5

Committee member

Activity description
Role 		Institution / Organization
2020 - Current Participação em Comissão de gestão de MSc. Internacional: Member of the Scientific Committee for the Erasmus Mundus MSc. in Chemical Innovation and Regulation - MSc. ChIR (PCm, ChIR Programme Committee member) || https://www.emmcchir.org/structure/ || https://www.emmcchir.org/news/?id=1st-meeting-of-the-chir-programme-committee
Member
 Universidade do Algarve - Campus de Gambelas, Portugal

Universitat de Barcelona, Spain

Università degli Studi di Bologna, Italy
2018/07/14 - 2018/07/19 ICS2018 - 29th European Carbohydrate Symposium || Member of the Organizing Committee | http://www.ics2018.eventos.chemistry.pt/ International conference aimed at stimulating new emerging areas in glycosciences, with contributions in topics covering recent advances in carbohydrate chemistry, biology and biotechnology; around 1750 participants
Member
 Universidade de Lisboa Faculdade de Ciências, Portugal
2006/09/10 - 2006/09/14 V5 - 5th International Symposium on the Chemistry and Biological Chemistry of Vanadium| Member of the Organizing Committee - symposium held within the 232nd American Chemical Society Meeting, The symposium is an interdisciplinary event for a wide range of chemistry researchers that share interest in vanadium research to network and update on developments. URL: http://franklin.chm.colostate.edu/dcc/V5-Symp/index.html – co-Chair: João Costa Pessoa; Chair: Debbie Crans
Member
 American Chemical Society, United States

Colorado State University, United States

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/04 - Current MSc. Erasmus Mundus in Chemical Innovation and Regulation - ChIR || Invited lecturer || Discipline Group 6 - Toxicological perspective (3 modules) || Subject 'Toxicology' (Master Universitario) Università degli Studi di Bologna, Italy

Universitat de Barcelona, Spain

Universidade do Algarve - Campus de Gambelas, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2017/04/04 Media Citations| In vivo Performance of a Ruthenium-cyclopentadienyl Compound in an Orthotopic Triple Negative Breast Cancer Model | This work reports our in vivo results for a Ruyhenium-cyclopentadienyl complex that was able to both reduce the primary tumor mass and prevent the formation of lung metastases. Selected by the Portuguse Association for Cancer Reseach (ASPIC in portuguese) under "News". http://www.aspic.pt/en/noticias/vivo-performance-ruthenium-cyclopentadienyl-compound-orthotopic-triple-negative-breast#.WOOhuYWcGj ASPIC, Associação Portuguesa de Investigação em Cancro - News - Website
2013/06/25 Media Citations| “Cancro: Portuguesas vencem prémio nos EUA" - piece of news on the first prize award (out of a total of 380 presentations) for the work and communication presented at the Drug Discovery & Therapy World Congress 2013 (held in Boston, USA, 3-6.June.2013) sapo website

Interview (tv / radio show)

Program Topic
2013/07/14 - 2013/07/14 Media Citations| Portuguese TV channel || "8 o'clock News journal"- TVI "Os comentários do Prof. Marcelo Rebelo de Sousa” was a section of the Sunday News TV journal dedicated tonterdisciplinary events that would have stood out during the course of the week. “Jornal das 8 (TVI): Os comentários do Prof. Marcelo Rebelo de Sousa”
Distinctions

Award

2015 RuPharma project | First prize in ScienceIN2Business®
Tec Labs - Innovation Centre for the Faculty of Sciences of University of Lisbon, Portugal
2013 First prize for research presented in a communication| Global award: $xxxx USD
Scientific Committee for "Drug Discovery & Therapy World Congress 2013" , United States
2013 iFCT2013 - Research Program (Starting Grant)
FCT - Fundação para a Ciência e Tecnologia, Portugal
2009 Ciência2008 - Auxiliar Researcher position
FCT - Fundação para a Ciência e Tecnologia, Portugal