???global.info.a_carregar???
Ana Isabel Aquino Friães. Completed the PhD in Health Sciences and Technologies in 2013 by Universidade de Lisboa Faculdade de Medicina, the MSc in Biotechnology in 2007 by Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, and the Degree in Applied Chemistry in 2002 by Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia. Currently is an Assistant Professor at Universidade de Lisboa Faculdade de Medicina and Researcher in Universidade de Lisboa Instituto de Medicina Molecular. Published 20 articles in international peer-reviewed journals. Organized 2 scientific events. Supervised 4 MSc dissertations. Has received 4 awards and/or honors. Participated as Researcher in 10 projects. Works in the area of Medical and Health Sciences with emphasis on Infectious Diseases. In her curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Streptococcus pyogenes; Antigens; Molecular typing; Infection; Microbiology; Antimicrobial resistance; Population biology; Virulence and genetic complement; Molecular epidemiology; Lancefield Group A Streptococcus; Bacterial virulence factors; Host-pathogen interactions.
Read full resume ↓
Identification

Personal identification

Full name
Ana Isabel de Aquino Friães

Citation names

  • Friães, Ana

Author identifiers

Ciência ID
B616-F64A-ACEF
ORCID iD
0000-0002-7567-2405
Google Scholar ID
nce7HysAAAAJ&hl
Researcher Id
A-5010-2009
Scopus Author Id
17345589300

Knowledge fields

  • Medical and Health Sciences - Health Sciences - Infectious Diseases

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1)
Spanish; Castilian Beginner (A1)
Education
Degree Classification
2013/11/13
Concluded
 Ciências e Tecnologias da Saúde (Doutoramento)
Major in Especialidade: Microbiologia
Universidade de Lisboa Faculdade de Medicina, Portugal
"Molecular characterization of Streptococus pyogenes isolates associated with invasive infections and pharyngitis in Portugal: evaluation of typing methods and relationship with invasive ability" (THESIS/DISSERTATION)
 Aprovado com distinção e louvor
2007/10/30
Concluded
 Biotecnologia (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Molecular Epidemiology of Streptococcus pyogenes Invasive Infections in Portugal" (THESIS/DISSERTATION)
 19
2002
Concluded
 Química Aplicada (Licenciatura)
Major in Biotecnologia
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"NA" (THESIS/DISSERTATION)
 18
Affiliation

Science

Category
Host institution 		Employer
2005/04/01 - Current Researcher (Research) Universidade de Lisboa Faculdade de Medicina, Portugal
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2004/10/01 - 2005/03/31 Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2003/04/01 - 2004/09/30 Researcher (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2013/11/13 - Current Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
2007/10/31 - 2013/11/13 Assistant (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
2005/04/01 - 2007/10/30 Trainee Assistant (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
Projects

Contract

Designation Funders
2017/01 - 2020/12 ONEIDA - An Omics Network to Prevent and Control Infectious Diseases and Antimicrobial Resistance
SAICTPAC/0015/2015
Researcher
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundos Europeus Estruturais e de Investimento e Fundação para a Ciência e Tecnologia
Concluded
2008/08/20 - 2012/02/19 Streptococcus pyogenes invasive disease and antimicrobial resistance - two faces of a changing pathogen
PTDC/SAU-ESA/72321/2006
Researcher
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007 - 2009 Caracterização microbiológica e molecular de Streptococcus spp. patogénicos e sua importância na profilaxia e terapêutica das infecções humanas em Portugal
N/A
Researcher
Universidade de Lisboa Faculdade de Medicina, Portugal
 Fundação Calouste Gulbenkian
Concluded

Other

Designation Funders
2019 - Current Non-invasive pneumococcal lower respiratory tract infection in Portugal: evolution of serotype prevalence, antimicrobial resistance and the impact of Prevenar 13
N/A
Researcher
Universidade de Lisboa Faculdade de Medicina, Portugal
 Pfizer Portugal
Ongoing
2016 - Current Streptococcus pneumoniae causing Invasive Pneumococcal Infections (IPD) in Portugal after the universal indication of Prevenar 13 (PCV13) for all ages in 2014, and the introduction in the children's national immunization plan (NIP) in 2015
N/A
Researcher
Universidade de Lisboa Faculdade de Medicina, Portugal
 Pfizer Portugal
Ongoing
2017 - 2019 Streptococcus pneumoniae causing Invasive Pneumococcal Infections (IPD) in Portugal after the universal indication of Prevenar 13 (PCV13) for all ages in 2014, and the introduction in the children’s national immunization plan (NIP) in 2015
N/A
Researcher
Universidade de Lisboa Faculdade de Medicina, Portugal
 Pfizer Portugal
Concluded
2014 - 2016 Streptococcus pneumoniae bacterial population causing invasive infections in Portugal and the impact of Prevenar 13
N/A
Researcher
Universidade de Lisboa Faculdade de Medicina, Portugal
 Pfizer Portugal
Concluded
2014 - 2014 Evaluation of the Xpert MRSA Gen 3 Assay protocol
N/A
Researcher
Universidade de Lisboa Faculdade de Medicina, Portugal
 Cepheid
Concluded
2005 - 2013 Projecto Viriato: Estudo epidemiológico nacional de susceptibilidade a antibióticos de bactérias isoladas em doentes com infecção respiratória adquirida na comunidade
N/A
Researcher
Universidade de Lisboa Faculdade de Medicina, Portugal
 Glaxo Wellcome Farmaceutica Lda
Concluded
2007 - 2009 POR-T.E.S.T. (Portuguese Tigecycline Evaluation Surveillance Test)
N/A
Researcher
Universidade de Lisboa Faculdade de Medicina, Portugal
 Wyeth Portugal
Concluded
Outputs

Publications

Conference abstract
  1. Silva-Costa, C.; Gomes-Silva, Joana; Pinho, Marcos Daniel; Friães, Ana; Ramirez, Mário; Melo Cristino, Jose; he Portuguese Group for the Study of Streptococcal Infections; Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society. "Serotype 3 dominance in pediatric complicated pneumococcal pneumonia in Portugal during the COVID-19 pandemic (2020-2022)". Paper presented in 16th European Meeting on the Molecular Biology of the Pneumococcus (EuroPneumo), Rethymno, 2023.
  2. Silva-Costa, C.; Gomes-Silva, Joana; Pinho, Marcos Daniel; Friães, Ana; Ramirez, Mário; Melo Cristino, Jose; Portuguese Group for the Study of Streptococcal Infections; Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society. "Pneumococci and serotype 3 remain important causes of complicated pneumonias despite six-years of near universal coverage of PCV13". Paper presented in 15th European Meeting on the Molecular Biology of the Pneumococcus - Europneumo, Liverpool, 2022.
  3. Silva-Costa, C.; Gomes-Silva, Joana; Pinho, Marcos Daniel; Friães, Ana; Ramirez, Mário; Melo Cristino, Jose; Portuguese Group for the Study of Streptococcal Infections; Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society. "Continued dominance of serotype 3 in paediatric complicated pneumococcal pneumonia in Portugal, five years after PCV13 introduction into routine infant immunisation". Paper presented in 32nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Lisbon, 2022.
  4. Friães, Ana; Marrão, Gina; Melo Cristino, Jose; Ramirez, Mário. "Decreasing macrolide resistance among group A streptococci causing pharyngitis in Portugal". Paper presented in 38th Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID), 2020.
  5. Gouveia, C.; Varandas, L.; Ramirez, Mário; Melo Cristino, Jose; Friães, Ana. "Clinical and bacterial characteristics of paediatric invasive infections caused by Streptococcus pyogenes". Paper presented in 30th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2020.
  6. Silva-Costa, C.; Brito, Maria João; Pinho, Marcos D.; Friães, Ana; Aguiar, Sandra I; Ramirez, Mário; Melo-Cristino, José; Portuguese Group for the Study of Streptococcal Infections; Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society. "Serotype 3 is the leading cause of complicated pediatric pneumococcal pneumonia in Portugal even among PCV13 vaccinated children (2010-2015)". Paper presented in 11th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-11), Melbourne, 2018.
    Published
  7. Friães, Ana; Melo-Cristino, José; Ramirez, Mário. "Genetic variation within the transcriptional regulator genes covR/S and ropB among invasive and non-invasive Streptococcus pyogenes isolates". Paper presented in XIX Lancefield International Symposium on Streptococci and Streptococcal Diseases, Buenos Aires, 2014.
    Published
  8. Carriço, João André; Friães, Ana; Prior, K.; Harmsen, D.; Ramirez, Mário; Melo-Cristino, José. "Whole genome analysis of the first vancomycin-resistant Staphylococcus aureus (VRSA) isolated in Europe". Paper presented in 24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Barcelona, 2014.
    Published
  9. Pato, Catarina; Friães, Ana; Ramirez, Mário; Melo-Cristino, José. "Characteristics of Streptococcus pyogenes causing skin and soft tissue infections in Portugal". Paper presented in 22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), London, 2012.
    Published
  10. Correia, M.; Brito, Maria João; Friães, Ana; Gouveia, Catarina. "Infecção grave por Staphylococcus aureus meticilina-susceptível, LPV negativo, adquirido na comunidade". Paper presented in VIII Encontro de Infecciologia Pediátrica, Lisbon, 2010.
    Published
  11. Carvalheiro, I.; Gouveia, Catarina; Friães, Ana; Tavares, D.; Varandas, Luís; Cassiano-Neves, M.. "Caso clínico: Piomiosite por Staphylococcus aureus meticilino-resistente adquirido na comunidade". Paper presented in VIII Encontro de Infecciologia Pediátrica, Lisbon, 2010.
    Published
  12. Pires, Renato; Friães, Ana; Silva-Costa, C.; Rolo, Dora; Brito-Avô, A.; Morais, A.; Gonçalo-Marques, J.; et al. "Relationship among macrolide resistant group A streptococci associated with oropharyngeal colonization and infection". Paper presented in XVII Lancefield International Symposium on Streptococci and Streptococcal Diseases, Porto Heli, 2008.
    Published
  13. Toste-Rêgo, Ana; Friães, Ana; Nicolau, Marta; Aragüés, J. M.; Mascarenhas, Mário Rui; Galvão-Teles, A.; Gonçalves, João. "Caracterização molecular do gene CYP21 em doentes com suspeita de deficiência em 21-hidroxilase". Paper presented in 6ª Reunião da Sociedade Portuguesa de Genética Humana, Porto, 2002.
    Published
Conference poster
  1. Gomes-Silva, Joana; Silva-Costa, C.; Pinho, Marcos Daniel; Friães, Ana; Ramirez, Mário; Melo Cristino, Jose; Portuguese Group for the Study of Streptococcal Infections; Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society. "Pediatric invasive pneumococcal disease: the importance of molecular methods in the diagnosis and serotyping of Streptococcus pneumoniae in culture negative samples". Paper presented in 16th International Conference on Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases, 2023.
  2. Boto, C.; Carneiro, S.; Carvalho, A.; Lemos, A.; Machado, P.; Pinto, M.; Friães, Ana; et al. "Comparação entre pneumonia por Streptococcus pneumoniae versus Streptococcus pyogenes". Paper presented in 23º Congresso Nacional de Pediatria, 2023.
  3. Couto, C.; Lemos, A.; Stella, L.; Sobral, C.; Pinto, M.; Melo Cristino, Jose; Friães, Ana; Ramirez, Mário; Gouveia, C.. "Infeção profunda dos tecidos moles por Streptococcus do grupo A, sem fasceíte - a propósito de uma série de casos". Paper presented in 23º Congresso Nacional de Pediatria, 2023.
  4. Gomes-Silva, Joana; Silva-Costa, C.; Pinho, Marcos Daniel; Friães, Ana; Ramirez, Mário; Melo Cristino, Jose; Portuguese Group for the Study of Streptococcal Infections; Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society. "Sustained importance of Streptococcus pneumoniae among pediatric complicated pneumonia in Portugal (2019-22)". Paper presented in 41st Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID), 2023.
  5. Gouveia, C.; Carvalho, A.; Rodrigues, F.; Varandas, L.; Ramirez, Mário; Melo Cristino, Jose; Friães, Ana; Portuguese Group for the Study of Streptococcal Infections; Portuguese Study Group of Pediatric Invasive Streptococcal Disease. "Pediatric invasive infections caused by Streptococcus pyogenes in Portugal (2014-2022)". Paper presented in 41st Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID), 2023.
  6. Gomes-Silva, Joana; Silva-Costa, C.; Pinho, Marcos Daniel; Ramirez, Mário; Melo Cristino, Jose; Portuguese Group For The Study Of Streptococcal Infections; Portuguese Study Group Of Invasive Pneumococcal Disease Of The Paediatric Infectious Diseases Society. "Etiologic diagnosis from pleural effusion and empyema in pediatrics: is it worth looking beyond Streptococcus pneumoniae in the post-pneumococcal vaccine era?". Paper presented in 33rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2023.
  7. Mamede, Rafael; Friães, Ana; Ferreira, Mariana; Melo Cristino, Jose; Ramirez, Mário. "Enabling high resolution typing of Streptococcus pyogenes with a novel whole-genome multilocus sequence typing schema". Paper presented in 13th International Meeting on Microbial Epidemiological Markers (IMMEM XIII), 2022.
  8. Silva-Costa, C.; Gomes-Silva, Joana; Pinho, Marcos Daniel; Friães, Ana; Ramirez, Mário; Melo Cristino, Jose; Portuguese Group for the Study of Streptococcal Infections; Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society. "Complicated pediatric pneumococcal pneumonia in the context of near universal vaccination in Portugal". Paper presented in 12th International Symposium on Pneumococci&Pneumococcal Diseases (ISPPD-12), 2022.
  9. Friães, Ana; Mamede, Rafael; Melo Cristino, Jose; Ramirez, Mário. "High resolution typing of Streptococcus pyogenes using a novel whole genome multilocus sequence typing (wgMLST) schema". Paper presented in 21st Lancefield International Symposium for Streptococci and Streptococcal Diseases (LISSSD), 2022.
  10. Gomes-Silva, Joana; Silva-Costa, C.; Pinho MD; Friães, Ana; Ramirez, Mário; Melo Cristino, Jose; Portuguese Group for the Study of Streptococcal Infections; Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society. "Looking beyond Streptococcus pneumoniae in culture-negative complicated pneumonia in children in Portugal (2010-19)". Paper presented in 32nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2022.
  11. Silva-Costa, C.; Gomes-Silva, Joana; Santos, A; Pinho, Marcos Daniel; Friães, Ana; Ramirez, Mário; Melo-Cristino, José; Portuguese Group for the Study of Streptococcal Infections. "Non-invasive pneumococcal pneumonia in Portugal (2016-2018): the importance of conjugate vaccine serotypes". 2022.
  12. Vila-Cerqueira, Pedro; Mamede, Rafael; Friães, Ana; Ramirez, Mário. "Defining publicly available whole-genome multilocus sequence typing schemas - the example of Streptococcus pyogenes". Paper presented in 31st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2021.
  13. Mamede, Rafael; Vila-Cerqueira, Pedro; Friães, Ana; Ramirez, Mário. "Towards a framework for the definition of publicly available whole-genome multilocus sequence typing schemas - the example of Streptococcus pyogenes". Paper presented in 2nd GenomePT Symposium, 2021.
  14. Vila-Cerqueira, Pedro; Mamede, Rafael; Friães, Ana; Ramirez, Mário. "Tracking strains is simpler if you use common schemas from public repositories". Paper presented in Applied Bioinformatics & Public Health Microbiology 2021, 2021.
  15. Gouveia, C.; Varandas, L.; Ramirez, Mário; Melo Cristino, Jose; Friães, Ana. "Pediatric invasive infections caused by Streptococcus pyogenes in Portugal (2014-2018)". Paper presented in 38th Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID), 2020.
  16. Silva-Costa, C.; Pinho, Marcos Daniel; Friães, Ana; Gomes-Silva, Joana; Ramirez, Mário; Melo Cristino, Jose; Portuguese Group for the Study of Streptococcal Infections; Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society. "Despite introduction of PCV13 into routine infant immunization serotype 3 continues to cause pediatric complicated pneumococcal pneumonia among vaccinees". Paper presented in 38th Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID), 2020.
  17. Silva-Costa, C.; Pinho, Marcos; Friães, Ana; Gomes-Silva, Joana; Guerreiro, Soraia; Brito, Maria; Ramirez, Mário; Melo-Cristino, José. "Molecular diagnostics reveals persistence of serotype 3 as the main cause of pediatric complicated pneumonia in Portugal despite extensive PCV13 use (P263)". Paper presented in 12th International Meeting on Microbial Epidemiological Markers (IMMEM XII), 2019.
  18. Silva-Costa, C.; Pinho, Marcos D.; Friães, Ana; Gomes-Silva, Joana; Guerreiro, Soraia; Brito, Maria João; Ramirez, Mário; et al. "Three years after PCV13 introduction in the National Immunization Plan serotype 3 is still the main cause of complicated pneumonia in Portugal (P46)". Paper presented in 14th European Meeting on the Molecular Biology of the Pneumococcus, 2019.
  19. Friães, Ana; Marrão, Gina; Ramirez, Mário; Melo-Cristino, José. "Low macrolide resistance and minimal clonal diversity among Streptococcus pyogenes causing pharyngitis in Portugal (P2837)". Paper presented in 29th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2019.
  20. Pignatelli, Diana; Janeiro, M.; Castaneda, C.; Morais, B.; Friães, Ana; Melo-Cristino, José; Sancho, Luísa; Barroso, R.. "Sépsis precoce com empiema e exantema - apresentação típica de uma infeção rara?". Paper presented in XLVII Jornadas Nacionais de Neonatologia, 2018.
  21. Silva-Costa, C.; Aguiar, Sandra I; Pinho, Marcos D.; Friães, Ana; Ramirez, Mário; Melo-Cristino, José; Portuguese Group for the Study of Streptococcal Infections; Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society. "Serotype distribution among Streptococcus pneumoniae isolates causing complicated pneumonia in children in Portugal (2010-2015)". Paper presented in 27th European Congress of Clinical Microbiology and Infectious Diseases, 2017.
  22. Friães, Ana; Lopes, Joana P.; Ramirez, Mário; Melo-Cristino, José. "Clonal stability among Group A Streptococci causing invasive infections in Portugal". Paper presented in 27th European Congress of Clinical Microbiology and Infectious Diseases, 2017.
  23. Silva-Costa, C.; Aguiar, Sandra I; Pinho, Marcos D.; Friães, Ana; Ramirez, Mário; Melo-Cristino, José; Portuguese Group for the Study of Streptococcal Infections; Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society. "High prevalence of serotype 3 in pneumococcal isolates causing complicated pneumonia and empyema in Portugal (2010-2015)". Paper presented in International Meeting on Emerging Diseases and Surveillance (IMED 2016), 2016.
  24. Pato, Catarina; Friães, Ana; Lopes, Joana P.; Ramirez, Mário; Melo-Cristino, José. "Comparison of Streptococcus pyogenes isolates from invasive and skin and soft tissue infections reveal differences in the capacity to interact with host proteins". Paper presented in 26th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2016.
  25. Silva-Costa, C.; Aguiar, Sandra I; Pinho, Marcos D.; Friães, Ana; Brito, Maria João; Ramirez, Mário; Melo-Cristino, José. "The advantage of various PCR-based techniques in the enhanced ethiological diagnosis of pediatric complicated pneumococcal pneumonia in Portugal". Paper presented in 9th World Congress of the World Society for Pediatric Infectious Diseases, 2015.
  26. Melo-Cristino, José; Friães, Ana; Resina, Cristina; MANUEL, V.; Lito, Luís; Ramirez, Mário. "Emergence of vancomycin resistant Staphylococcus aureus (VRSA) in Portugal". Paper presented in International Meeting on Emerging Diseases and Surveillance, 2014.
  27. Melo-Cristino, José; Friães, Ana; Resina, Cristina; MANUEL, V.; Lito, Luís; Ramirez, Mário. "Detection, evolution and outcome of the first case of Vancomycin Resistant Staphylococcus aureus (VRSA) infection in Europe". Paper presented in ID Week 2014, 2014.
  28. Silva-Costa, C.; Friães, Ana; Ramirez, Mário; Melo-Cristino, José; Portuguese Group for the Study of Streptococcal Infections. "Importance of clonal properties in addition to antibiotic consumption in determining the differences between macrolide resistant and susceptible Streptococcus pyogenes.". Paper presented in International Meeting on Emerging Diseases and Surveillance, 2013.
  29. Silva-Costa, C.; Friães, Ana; Pinho, Marcos D.; Ramirez, Mário; Melo-Cristino, José. "Dinamics of susceptibility to tigecycline and to an extended panel of antimicrobials of Gram-positive and Gram-negative bacteria in Portugal (2005-2011)". Paper presented in 52th Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), 2012.
  30. Pato, Catarina; Friães, Ana; Ramirez, Mário; Melo-Cristino, José. "Molecular characterization and antimicrobial resistance of Streptococcus pyogenes causing skin and soft tissue infections in Portugal". Paper presented in XVIII Lancefield International Symposium, 2011.
  31. Friães, Ana; Lopes, Joana P.; Ramirez, Mário; Melo-Cristino, José. "Molecular changes in Streptococcus pyogenes invasive isolates recovered during ten years in Portugal". Paper presented in XVIII Lancefield International Symposium, 2011.
  32. Friães, Ana; Silva-Costa, C.; Pinto, Francisco R; Ramirez, Mário; Melo-Cristino, José. "Identification of clones with enhanced invasive capacity among Group A Streptococci isolated in Portugal". Paper presented in XVIII Lancefield International Symposium, 2011.
  33. Silva-Costa, Catarina; Friães, Ana; Pinho, Marcos D.; Ramirez, Mário; Melo-Cristino, José. "In vitro susceptibility to Tigecycline and to an extended panel of antimicrobials of Gram-positive and Gram-negative isolates in Portugal". Paper presented in 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 2010.
  34. Silva-Costa, C.; Friães, Ana; Pinho, Marcos Daniel; Ramirez, Mário; Melo Cristino, Jose. "In vitro susceptibility to tigecycline and to an extended panel of antimicrobials of Gram positive and Gram negative isolates in Portugal. P204". Paper presented in 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2009.
  35. Friães, Ana; Silva-Costa, C.; Vaz, Filipa; Fernandes, Paulo; Carriço, João André; Pires, Renato; Santos-Sanches, Ilda; Ramirez, Mário; Melo-Cristino, José. "Quantitative comparison of Streptococcus pyogenes typing methods". Paper presented in XVII Lancefield International Symposium on Streptococci and Streptococcal Diseases, 2008.
  36. Silva-Costa, C.; Friães, Ana; Vaz, Filipa; Fernandes, Paulo; Carriço, João André; Melo-Cristino, José; Ramirez, Mário. "Re-evaluating the appropriateness of using emm typing to define group A streptococci clones". Paper presented in 8th International Meeting on Microbial Epidemiological Markers (IMMEM 8), 2008.
  37. Friães, Ana; Ramirez, Mário; Melo-Cristino, José. "Characterization of an emm12/T12 GAS clone associated with paediatric invasive disease in Portugal". Paper presented in 18th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2008.
Journal article
  1. Gouveia, C.; Bajanca-Lavado, Maria Paula; Mamede, Rafael; Carvalho, A.; Rodrigues, F.; Melo Cristino, Jose; Ramirez, Mário; et al. "Sustained increase of paediatric invasive Streptococcus pyogenes infections dominated by M1UK and diverse emm12 isolates, Portugal, September 2022 to May 2023". Eurosurveillance (2023): https://doi.org/10.2807/1560-7917.ES.2023.28.36.2300427.
    10.2807/1560-7917.ES.2023.28.36.2300427
  2. Silva-Costa, C.; Gomes-Silva, Joana; Pinho, Marcos Daniel; Friães, Ana; Ramirez, Mário; Melo Cristino, Jose. "Continued Vaccine Breakthrough Cases of Serotype 3 Complicated Pneumonia in Vaccinated Children, Portugal (2016-2019).". Microbiology spectrum (2022): https://doi.org/10.1128/spectrum.01077-22.
    10.1128/spectrum.01077-22
  3. Friães, Ana; Mamede, Rafael; Ferreira, Mariana; Melo Cristino, Jose; Ramirez, Mário. "Annotated Whole-Genome Multilocus Sequence Typing Schema for Scalable High-Resolution Typing of Streptococcus pyogenes.". Journal of clinical microbiology (2022): https://doi.org/10.1128/jcm.00315-22.
    10.1128/jcm.00315-22
  4. Friães, Ana; Melo Cristino, Jose; Ramirez, Mário; Portuguese Group for the Study of Streptococcal Infections. "Changes in emm types and superantigen gene content of Streptococcus pyogenes causing invasive infections in Portugal". Scientific Reports (2019): https://doi.org/10.1038/s41598-019-54409-2.
    Open access • 10.1038/s41598-019-54409-2
  5. Pato C; Melo-Cristino J; Ramirez M; Friães A; Portuguese Group for the Study of Streptococcal Infections. "Streptococcus pyogenes Causing Skin and Soft Tissue Infections Are Enriched in the Recently Emerged emm89 Clade 3 and Are Not Associated With Abrogation of CovRS.". Frontiers in microbiology (2018): http://europepmc.org/abstract/med/30356787.
    Open access • 10.3389/fmicb.2018.02372
  6. Silva-Costa C; Brito MJ; Pinho MD; Friães A; Aguiar SI; Ramirez M; Melo-Cristino J; Portuguese Group for the Study of Streptococcal Infections; Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society. "Pediatric Complicated Pneumonia Caused by Streptococcus pneumoniae Serotype 3 in 13-Valent Pneumococcal Conjugate Vaccinees, Portugal, 2010-2015.". Emerging infectious diseases (2018): http://europepmc.org/abstract/med/29912700.
    Open access • 10.3201/eid2407.180029
  7. Friães, Ana; Machado, Miguel P.; Pato, Catarina; Carriço, João; Melo-Cristino, José; Ramirez, Mario. "Emergence of the Same Successful Clade among Distinct Populations of emm89 Streptococcus pyogenes in Multiple Geographic Regions". mBio 6 6 (2015): http://dx.doi.org/10.1128/mbio.01780-15.
    10.1128/mbio.01780-15
  8. Friães, Ana; Pato, Catarina; Melo-Cristino, José; Ramirez, Mario. "Consequences of the variability of the CovRS and RopB regulators among Streptococcus pyogenes causing human infections". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep12057.
    10.1038/srep12057
  9. Coelho, Luis Pedro; Pato, Catarina; Friães, Ana; Neumann, Ariane; von Köckritz-Blickwede, Maren; Ramirez, Mário; Carriço, João André. "Automatic determination of NET (neutrophil extracellular traps) coverage in fluorescent microscopy images". Bioinformatics 31 14 (2015): 2364-2370. http://dx.doi.org/10.1093/bioinformatics/btv156.
    10.1093/bioinformatics/btv156
  10. Silva-Costa, Catarina; Friães, Ana; Ramirez, Mario; Melo-Cristino, Jose. "Macrolide-resistant Streptococcus pyogenes: prevalence and treatment strategies". Expert Review of Anti-infective Therapy 13 5 (2015): 615-628. http://dx.doi.org/10.1586/14787210.2015.1023292.
    10.1586/14787210.2015.1023292
  11. Friães, Ana; Resina, Cristina; Manuel, Viviana; Lito, Luís; Ramirez, Mário; Melo-Cristino, José. "Epidemiological survey of the first case of vancomycin-resistant Staphylococcus aureus infection in Europe". Epidemiology and Infection 143 4 (2014): 745-748. http://dx.doi.org/10.1017/s0950268814001423.
    10.1017/s0950268814001423
  12. Neumann, Ariane; Völlger, Lena; Berends, Evelien T.M.; Molhoek, E. Margo; Stapels, Daphne A.C.; Midon, Marika; Friães, Ana; et al. "Novel Role of the Antimicrobial Peptide LL-37 in the Protection of Neutrophil Extracellular Traps against Degradation by Bacterial Nucleases". Journal of Innate Immunity 6 6 (2014): 860-868. http://dx.doi.org/10.1159/000363699.
    10.1159/000363699
  13. Friães, Ana; Lopes, Joana P.; Melo-Cristino, José; Ramirez, Mario; Portuguese Group for the Study of Streptococcal Infections. "Changes in Streptococcus pyogenes causing invasive disease in Portugal: Evidence for superantigen gene loss and acquisition". International Journal of Medical Microbiology 303 8 (2013): 505-513. http://dx.doi.org/10.1016/j.ijmm.2013.07.004.
    10.1016/j.ijmm.2013.07.004
  14. Silva-Costa, C.; Friães, A.; Ramirez, M.; Melo-Cristino, J.; Portuguese Group for the Study of Streptococcal Infections. "Differences between Macrolide-Resistant and -Susceptible Streptococcus pyogenes: Importance of Clonal Properties in Addition to Antibiotic Consumption". Antimicrobial Agents and Chemotherapy 56 11 (2012): 5661-5666. http://dx.doi.org/10.1128/aac.01133-12.
    10.1128/aac.01133-12
  15. Friães, A.; Pinto, F. R.; Silva-Costa, C.; Ramirez, M.; Melo-Cristino, J.. "Superantigen gene complement of Streptococcus pyogenes - relationship with other typing methods and short-term stability". European Journal of Clinical Microbiology & Infectious Diseases 32 1 (2012): 115-125. http://dx.doi.org/10.1007/s10096-012-1726-3.
    10.1007/s10096-012-1726-3
  16. Friães, Ana; Pinto, Francisco R; Silva-Costa, Catarina; Ramirez, Mario; Melo-Cristino, José; Portuguese Group for the Study of Streptococcal Infections. "Group A streptococci clones associated with invasive infections and pharyngitis in Portugal present differences in emm types, superantigen gene content and antimicrobial resistance". BMC Microbiology 12 1 (2012): 280. http://dx.doi.org/10.1186/1471-2180-12-280.
    10.1186/1471-2180-12-280
  17. Melo-Cristino, José; Santos, Letícia; Silva-Costa, Catarina; Friães, Ana; Pinho, Marcos D.; Ramirez, Mário; Portuguese Surveillance Group for the Study of Respiratory Pathogens. "The Viriato Study". Pediatric Drugs 12 (2010): 11-17. http://dx.doi.org/10.2165/11538730-s0-000000000-00003.
    10.2165/11538730-s0-000000000-00003
  18. Friães, A.; Ramirez, M.; Melo-Cristino, J.; Portuguese Group for the Study of Streptococcal Infections. "Nonoutbreak Surveillance of Group A Streptococci Causing Invasive Disease in Portugal Identified Internationally Disseminated Clones among Members of a Genetically Heterogeneous Population". Journal of Clinical Microbiology 45 6 (2007): 2044-2047. http://dx.doi.org/10.1128/jcm.00496-07.
    10.1128/jcm.00496-07
  19. Gonçalves, João; Friães, Ana; Moura, Luís; Gonçalves J; Friães A; Moura L. "Congenital adrenal hyperplasia: focus on the molecular basis of 21-hydroxylase deficiency". Expert Reviews in Molecular Medicine 9 11 (2007): 1-23. http://dx.doi.org/10.1017/s1462399407000300.
    10.1017/s1462399407000300
  20. Friães, Ana; Rêgo, Ana Toste; Aragüés, José Maria; Moura, Luís Francisco; Mirante, Alice; Mascarenhas, Mário Rui; Kay, Teresa Taylor; et al. "CYP21A2 mutations in Portuguese patients with congenital adrenal hyperplasia: Identification of two novel mutations and characterization of four different partial gene conversions". Molecular Genetics and Metabolism 88 1 (2006): 58-65. http://dx.doi.org/10.1016/j.ymgme.2005.11.015.
    10.1016/j.ymgme.2005.11.015
Thesis / Dissertation
  1. Friaes, Ana Isabel de Aquino, 1979-. "Molecular characterization of Streptococcus pyogenes isolates associated with invasive infections and pharyngitis in Portugal: evaluation of typing methods and relationship with invasive ability". PhD, Universidade de Lisboa Faculdade de Medicina, 2013. http://hdl.handle.net/10451/9649.
  2. Friães, Ana. "Molecular Epidemiology of Streptococcus pyogenes Invasive Infections in Portugal". Master, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2007.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/12/15 Doença Invasiva por Streptococcus pyogenes - O Laboratório Reunião sobre estudos multicêntricos da Sociedade de Infecciologia Pediárica
Sociedade de Infecciologia Pediárica (Alcobaça, Portugal)
2023/05/08 Upsurge of pediatric invasive Streptococcus pyogenes (Group A Streptococcus) infections in Portugal dominated by M1UK and emm12 lineages 41st Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID)
European Society for Paediatric Infectious Diseases (Lisbon, Portugal)
2022/06/07 Core-genome multilocus sequence typing (cgMLST) of Streptococcus pyogenes reveals an increasing prevalence of the M1UK clone among invasive disease in Portugal (2016-2019) 21st Lancefield International Symposium for Streptococci and Streptococcal Diseases (LISSSD)
(Stockholm, Sweden)
2022/04/23 Comparison of a novel whole-genome multilocus sequence typing (wgMLST) schema for Streptococcus pyogenes with other typing methods 32nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
European Society of Clinical Microbiology and Infectious Diseases (ESCMID) (Lisbon, Portugal)
2019/01/23 Streptococcus pyogenes infections: at the crossroads between epidemiology, virulence genes and regulation
University of Veterinary Medicine, Hannover (Hannover, Germany)
2013/03 Superantigen gene complement of group A streptococci: short-term stability and association with invasive infections GAS Infections 2013
(Rome, Italy)
2011/04/20 Identification of clones with enhanced invasive capacity among Group A Streptococci isolated in Portugal: possible relation with NET evasion
University of Veterinary Medicina, Hannover (Hannover, Germany)
2010/04 Antimicrobial resistance among invasive Streptococcus pyogenes isolates in Portugal 20th European Congress of Clinical Microbiology and Infectious Diseases
European Society of Clinical Microbiology and Infectious Diseases (Vienna, Austria)
2010/04 Infrequent deletion of the chromosomal genes speB and speF in GAS clinical isolates 20th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
European Society Of Clinical Microbiology and Infectious Diseases (Vienna, Austria)
2004/05 Searching for recombination events associated with 21-hydroxylase deficiency EMBO Workshop – Recombination Mechanisms – 40th Anniversary Meeting of the Holliday Model
EMBO (Seillac, France)
2003/11 Estudo molecular da deficiência em 21-hidroxilase em doentes com hiperplasia supra-renal congénita 7ª Reunião da Sociedade Portuguesa de Genética Humana
Sociedade Portuguesa de Genética Humana (Lisbon, Portugal)
2002/11 Pesquisa de mutações no gene CYP21 em indivíduos com suspeita de deficiência em 21-hidroxilase III Congresso da Sociedade Portuguesa de Endocrinologia e Diabetologia Pediátrica
Sociedade Portuguesa de Endocrinologia e Diabetologia Pediátrica (Lisbon, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/09 - Current Sreptococcus pyogenes associado a infeção invasiva no Homem em Portugal: caracterização genómica e resistência antimicrobiana
Supervisor
 Microbiologia Clínica e Doenças Infeciosas Emergentes (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/09 - 2023/09 Exploring the genetic variability of Streptococcus pyogenes virulence factors and its phenotypic impact
Supervisor
 Mestrado em Microbiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2018/09 - 2023/03/27 Determinação da atividade de fatores de virulência em estirpes de Streptococcus pyogenes isoladas de diferentes tipos de infeção
Supervisor
 Microbiologia Clínica e Doenças Infeciosas Emergentes (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2018 Genomic characterization and quantification of virulence factor activities in Streptococcus pyogenes isolated from human infections
Supervisor
 Microbiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2015/01/02 - 2016/03/12 Member of the Local Organizing Committee of the 11th International Meeting on Microbial Epidemiological Markers (IMMEM XI), Estoril, Portugal, 9-12th March 2016 (2016/03/09 - 2016/03/12)
Congress (Member of the Organising Committee)
 European Society of Clinical Microbiology and Infectious Diseases, Switzerland
2003/01/02 - 2003/11/28 Member of the Local Organizing Committee of 7ª Reunião da Sociedade Portuguesa de Genética Humana, Lisbon, Portugal, 26-28th November 2003. (2003/11/26 - 2003/11/28)
Congress (Member of the Organising Committee)
 Sociedade Portuguesa de Genética Humana, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/12/20 Facing macrolide and lincosamide resistance in Streptococcus under the light of whole genome sequencing Dàmaris Berbel Palau (PhD)
Universitat de Barcelona Facultat de Medicina i Ciències de la Salut, Spain
2023/03/27 Determinação da atividade de fatores de virulência em estirpes de Streptococcus pyogenes isoladas de diferentes tipos de infeção
Supervisor
 Beatriz Gonçalves Esteves (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018 Naturally occurring mutations in regulatory proteins among Streptococcus pyogenes isolates from distinct human infections
Thesis Member
 Catarina Teresa Condinho Pato (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018 Genomic characterization and quantification of virulence factor activities in Streptococcus pyogenes isolated from human infections
Supervisor
 Mariana Isabel Pinto Ferreira (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2011 Caracterização molecular de produtos de recombinação ilegítima envolvendo o agrupamento génico CYP21A1P-CYP21A2 em doentes com hiperplasia supra-renal congénita
(Thesis) Main arguer
 Ana Rita Tarelho (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2023/09/21 - Current Scientific Reports
2023/08/02 - Current The Lancet Microbe
2022/09/29 - Current Frontiers in Cellular and Infection Microbiology
2021/07/28 - Current Research in Microbiology
2021/06/01 - Current BMC Infectious Diseases
2021/02/01 - Current Emerging Infectious Diseases
2020/07/20 - Current Infection and Drug Resistance
2020/02 - Current Frontiers in Microbiology (1664-302X) Frontiers Media SA
2019/11 - Current GERMS (2248-2997) Asociatia Pentru Cresterea Vizibilitatii Cercetarii Stiintifice (ACVCS)
2016/11 - Current Microbiology (1608-3237) Pleiades Publishing
2016/06 - Current Molecular Microbiology (1365-2958) Wiley (Blackwell Publishing)
2016 - Current Infection Genetics and Evolution (1567-1348) Elsevier
2015/10 - Current Diagnostic Microbiology and Infectious Disease (0732-8893) Elsevier
2015/04 - Current Journal of Medical Microbiology (1473-5644) Microbiology Society
2015/04 - Current PLoS ONE (1932-6203) Public Library of Science
2015/01 - Current Clinical Microbiology and Infection (1469-0691) Elsevier
2014/06 - Current The Pediatric Infectious Disease Journal (1532-0987) Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
2013/03 - Current Journal of Infection (0163-4453) Elsevier
2011/10 - Current International Journal of Medical Microbiology (1438-4221) Elsevier

Association member

Society Organization name Role
2010 - Current European Society of Clinical Microbiology and Infectious Diseases
2022 - 2022 The Lancefield Society
2010 - 2014 Sociedade Portuguesa de Bioquímica
2002 - 2005 Sociedade Portuguesa de Genética Humana

Committee member

Activity description
Role 		Institution / Organization
2022/01 - Current "Equipa de Gestão e Resposta ao alerta de aumento de número de casos de infeção por estreptococos A" - member of the management and response team gathered by the Portuguese national health authorities in response to the ECDC alert on the increasing number of group A streptococci infections in late 2022. Advised and directly participated on the collection and molecular characterization of invasive GAS isolates.
Member
 Direção-Geral da Saúde, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2022/09 - 2022/10 External reviewer of the CIISA's CONT/INOV grant call 2022 in the Microbiology panel.
Evaluator
 Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária

Journal scientific committee

Journal title (ISSN) Publisher
2023/03 - Current Frontiers in Pediatrics (2296-2360) Frontiers

Mentoring / Tutoring

Topic Student name
2024/02/19 - 2024/06/07 Antimicrobial resistance and genomic characterization of Streptococcus pyogenes isolates from human infections Julie Vermeiren
2023/07 - 2023/07 Antimicrobial resistance and genomic characterization of Streptococcus pyogenes isolates from human infections Juliana Peixoto
2023/07 - 2023/07 Antimicrobial resistance and genomic characterization of Streptococcus pyogenes isolates from human infections Gréta Kovácová
2023/07 - 2023/07 Antimicrobial resistance and genomic characterization of Streptococcus pyogenes isolates from human infections Kirsten Felicity Greve
2022/07 - 2022/07 Antimicrobial resistance of Streptococcus pyogenes isolates from human infections Lucas Petri
2019/08 - 2019/08 Antimicrobial resistance of Streptococcus isolates from human infections Nejra Mlaco
2018/10 - 2019/01 Pedagogical initiation internship - Microbiology practical course Isabel Ferreira de Almeida
2019 - 2019 Antimicrobial resistance of Streptococcus pyogenes isolates from human infections Tiago Ferreira
2019 - 2019 Antimicrobial resistance of Streptococcus pyogenes isolates from human infections Francisca Melo
2017/10 - 2018/01 Pedagogical initiation internship - Microbiology practical course Ana Rita Sampaio Oliveira
2014 - 2014 Molecular characterization of Streptococcus pyogenes isolated from human infections Ana Catarina Jorge Mendes
2007/09 - 2008/07 Molecular characterization of Streptococcus pyogenes isolated from human infections Paulo Fernandes
2007/07 - 2007/07 Antimicrobial resistance of Streptococcus pyogenes isolates from human infections Amaury Pachione

Other jury / evaluation

Activity description Institution / Organization
2023 - 2023 Abstract reviewer for the 41st Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID 2023), Lisbon, Portugal, 8-12 May 2023.
2023 - 2023 Abstract reviewer for the 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2024), Barcelona, Spain, 27-30 April 2024
2021 - 2021 Abstract reviewer for the 39th Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID 2021), Online, 24-29 May 2021
Distinctions

Award

2003 Melhor Aluno da Faculdade de Ciências e Tecnologia Ano Lectivo 2001/2002 (Best Student 2001/2002)
Fundação da Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, Portugal
2003 Prémio FCT para Melhor Aluno de Química Aplicada 2001/2002 (Best Student in Applied Chemistry 2001/2002)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2003 Jovem Investigador (Young Investigator)
Sociedade Portuguesa de Genética Humana, Portugal
2002 Prémio para melhor apresentação oral (Best Oral Presentation)
Sociedade Portuguesa de Endocrinologia e Diabetologia Pediátrica, Portugal

Other distinction

2011 FEBS Short Term Fellowship
Federation of European Biochemical Societies, United Kingdom
2011 ESCMID Travel Grant for Training in a Foreign Institution 2011
European Society of Clinical Microbiology and Infectious Diseases, Switzerland